Yeast surface display for screening combinatorial polypeptide libraries

Nature Biotechnology

Volumn 15, Issue 6, 1997, Pages 553-557

  Boder, Eric T ^a   Wittrup, K Dane ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Affinity maturation; Antibody engineering; Combinatorial librarary; scFv; Surface display

Indexed keywords

FUNGAL PROTEIN; POLYPEPTIDE;

ANTIGEN BINDING; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL SURFACE; FLOW CYTOMETRY; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; SACCHAROMYCES CEREVISIAE; YEAST;

EUKARYOTA; MAMMALIA; SACCHAROMYCES CEREVISIAE; TRIXIS;

EID: 0030994634     PISSN: 0733222X     EISSN: None     Source Type: Journal    
DOI: 10.1038/nbt0697-553     Document Type: Article

References (28)

1. Smith, G.R 1985. Ramenions fusion phage: novel expression vectors that display cloned antigens on the virion surface. Science 228:1315-1317.
2. Burton, D.R. 1993. Monoclonal antibodies from combinatorial libraries. Acc. Chem. Res. 26:405-411.
3. Winter, G., Griffiths, A.D., Hawkins, RE, and Hoogenboom, H.R. 1994. Making antibodies by phage display technology. Annu. Rev. Immunol. 12:433-455.
4. Barbas, S.M. and Barbas, C.F. 1992. Filamentous phage display. Fibrinolysis 8:245-252.
5. Griffiths, A.D., et al. 1994. Isolation of high affinity human antibodies directly from large synthetic repertoires. EMBO J. 13:3245-3260.
6. Griffiths, A.D., et al. 1993. Human anti-self antibodies with high specificity from phage display libraries. EMBO J. 12:725-734.
7. Schlom, J., et al. 1992. Therapeutic advantage of high-affinity anticarcinoma radioimmunoconjugates. Cancer Res. 52:1067-1072.
8. Schier, R., et al. 1996. Isolation of high-affinity monomeric human anti-c-ertB-2 single chain Fv using affinity-driven selection. J. Mol. Biol. 255:28-43.
9. Hawkins, RE, Russell, S.J., and Winter, G. 1992. Selection of phage antibodies by binding affinity: mimicking affinity maturation. J. Mol. Biol. 226:889-896.
10. Hawkins, R.E., Russell, S.J., Baier, M., and Winter, G. 1993. The contribution of contact and non-contact residues of antibody in the affinity of binding to antigen: the interaction of mutant D1.3 antibodies with lysozyme. J. Mol. Biol. 234:958-964.
11. Ulrich, H.D., Patten, PA, Yang, P.L., Romesberg, F.E., and Schultz, P.G. 1995. Expression studies of catalytic antibodies. Proc. Natl Acad. Sci. USA 92:11907-11911.
12. Vaughan, T.J., et al. 1996. Human antibodies with sub-nanomolar affinities isolated from a large non-immunized phage display library. Nature Biotechnology 14:309-314.
13. Deng, S. J., et al. 1995. Basis for selection of improved carbohydrate-binding single-chain antibodies from synthetic gene libraries. Proc. Natl. Acad. Sci. USA 92:4992-4996.
14. Hockney, R.C. 1994. Recent developments in heterologous protein production in Escherichia coli. Trends Biotecnnol. 12:456-463.
15. Georgiou, G., Stathopoulos, C., Daugherty, P.S., Nayak, A.R., Iverson, B.L., and Curtiss, R. III. 1997. Display of heterologous proteins on the surface of microorganisms: from the screening of combinatorial libraries to live recombinant vaccines. Nature Biotechnology 15:29-34.
16. Francisco, J.A., Campbell, R., Iverson, B.L., and Georgiou, G. 1993. Production and fluorescence-activated cell sorting of Escherichia coli expressing a functional antibody fragment on the external surface. Roc. Natl Acad. Sci. USA 90:10444-10448.
17. Kretzschmar, T., Zimmerman, C., and Geiser, M. 1995. Selection procedures for nonmatured phage antibodies: a quantitative comparison and optimization strategies. Anal. Biochem. 224:413-419.
18. Phizicky, E.M. and Fields, S. 1995. Protein-protein interactions - methods for detection and analysis. Microbio. Rev. 59:94-123.
19. Lu, C.-F., Montijn, R.C., Brown, J.L., Klis, F., Kurjan, J., Bussey, H., et al. 1995. Glycosyl phosphatidylinositol-dependent cross-linking of alpha-agglutinin and beta 1,6-glucan in the Saccharomyces cerevisiae cell wall. J. Cell Biol. 128:333-340.
20. Schreuder, M.P., Brekelmans, S., Van Den Ende, H., and Klis, P.M. 1993. Targeting of a heterologous protein to the cell wall of Saccharomyces cerevisiae. Yeast 9:399-409.
21. Schreuder, M.P., Mooren, A.T.A., Toschka, H.Y., Verrips, C.T., and Klis, F.M. 1996. Immobilizing proteins on the surface of yeast cells. Trends Biotechnol. 14:115-120.
22. Roy, A., Lu, C.F., Marykwas, D.L., Lipke, P.N., and Kurjan, J. 1991. The AGA1 product is involved in cell surface attachment of the Saccharomyces cerevisiae cell adhesion glycoprotein a-agglutinin. Mol. Cell. Biol. 11:4196-4206.
23. Cappellaro, C., Baldermann, C., Rachel, R., and Tanner, W. 1994. Mating type-specific cell-cell recognition of Saccharomyces cerevisiae: cell wall attachment and active sites of a- and α-agglutinin. EMBO J. 13:4737-4744.
24. Johnston, M. and Davis, R.W. 1984. Sequences that regulate the divergent GAL1-GAL10 promoter in Saccharomyces cerevisiae. Mol. Cell. Biol. 4:1440-1448.
25. Low, N.M., Holliger, P., and Winter, G. 1996. Mimicking somatic hypermutation: affinity maturation of antibodies displayed on bacteriophage using a bacterial mutator strain. J. Mol. Biol. 260:359-368.
26. Parekh, R.N., Forrester, K.J., and Wittrup, K.D. 1995. Multicopy overexpression of bovine pancreatic trypsin inhibitor saturates the protein folding and secretory capacity of Saccharomyces cerevisiae. Protein Expr. Purif. 6:537-545.
27. Gietz, R.D. and Sugino, A. 1988. New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites. Gene 74:527-534.
28. Gietz, R.D. and Schiestl, R.H. 1996. Transforming yeast with DNA. Methods in Molecular and Cellular Biology. 5:255-269.