메뉴 건너뛰기




Volumn 218, Issue , 2015, Pages 94-113

Technologies for controlled, local delivery of siRNA

Author keywords

Gene silencing; Local delivery; siRNA

Indexed keywords

CHEMICAL MODIFICATION; GENETIC ENGINEERING;

EID: 84945196020     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2015.09.066     Document Type: Review
Times cited : (69)

References (227)
  • 1
    • 60149088848 scopus 로고    scopus 로고
    • Origins and mechanisms of miRNAs and siRNAs
    • R.W. Carthew, and E.J. Sontheimer Origins and mechanisms of miRNAs and siRNAs Cell 136 2009 642 655
    • (2009) Cell , vol.136 , pp. 642-655
    • Carthew, R.W.1    Sontheimer, E.J.2
  • 2
    • 58549084364 scopus 로고    scopus 로고
    • Antisense makes sense in engineered regenerative medicine
    • Y. Yao, C. Wang, R.R. Varshney, and D.A. Wang Antisense makes sense in engineered regenerative medicine Pharm. Res. 26 2009 263 275
    • (2009) Pharm. Res. , vol.26 , pp. 263-275
    • Yao, Y.1    Wang, C.2    Varshney, R.R.3    Wang, D.A.4
  • 3
    • 77956667224 scopus 로고    scopus 로고
    • Selective gene silencing by viral delivery of short hairpin RNA
    • K. Sliva, and B.S. Schnierle Selective gene silencing by viral delivery of short hairpin RNA Virology 7 2010 248
    • (2010) Virology , vol.7 , pp. 248
    • Sliva, K.1    Schnierle, B.S.2
  • 4
    • 31544456413 scopus 로고    scopus 로고
    • Insights into the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging
    • D.W. Bartlett, and M.E. Davis Insights into the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging Nucleic Acids Res. 34 2006 322 333
    • (2006) Nucleic Acids Res. , vol.34 , pp. 322-333
    • Bartlett, D.W.1    Davis, M.E.2
  • 5
    • 33645148088 scopus 로고    scopus 로고
    • The silent treatment: SiRNAs as small molecule drugs
    • D.M. Dykxhoorn, D. Palliser, and J. Lieberman The silent treatment: SiRNAs as small molecule drugs Gene Ther. 13 2006 541 552
    • (2006) Gene Ther. , vol.13 , pp. 541-552
    • Dykxhoorn, D.M.1    Palliser, D.2    Lieberman, J.3
  • 8
    • 84908564426 scopus 로고    scopus 로고
    • Current issues of RNAi therapeutics delivery and development
    • D. Haussecker Current issues of RNAi therapeutics delivery and development J. Control Release 195 2014 49 54
    • (2014) J. Control Release , vol.195 , pp. 49-54
    • Haussecker, D.1
  • 9
    • 78651388588 scopus 로고    scopus 로고
    • SiRNA knockdown of ribonucleotide reductase inhibits melanoma cell line proliferation alone or synergistically with temozolomide
    • J.E. Zuckerman, T. Hsueh, R.C. Koya, M.E. Davis, and A. Ribas SiRNA knockdown of ribonucleotide reductase inhibits melanoma cell line proliferation alone or synergistically with temozolomide J. Invest. Dermatol. 131 2011 453 460
    • (2011) J. Invest. Dermatol. , vol.131 , pp. 453-460
    • Zuckerman, J.E.1    Hsueh, T.2    Koya, R.C.3    Davis, M.E.4    Ribas, A.5
  • 12
    • 84867652280 scopus 로고    scopus 로고
    • The business of RNAi therapeutics in 2012
    • D. Haussecker The business of RNAi therapeutics in 2012 Mol. Ther. Nucleic Acids 1 2012 e8
    • (2012) Mol. Ther. Nucleic Acids , vol.1
    • Haussecker, D.1
  • 13
    • 84896717533 scopus 로고    scopus 로고
    • Nanotoxicity: A key obstacle to clinical translation of siRNA-based nanomedicine
    • H.Y. Xue, S. Liu, and H.L. Wong Nanotoxicity: a key obstacle to clinical translation of siRNA-based nanomedicine Nanomed 9 2014 295 312
    • (2014) Nanomed , vol.9 , pp. 295-312
    • Xue, H.Y.1    Liu, S.2    Wong, H.L.3
  • 15
    • 36148997263 scopus 로고    scopus 로고
    • Modulation of scratching behavior by silencing an endogenous cyclooxygenase-1 gene in the skin through the administration of siRNA
    • T. Inoue, M. Sugimoto, T. Sakurai, R. Saito, N. Futaki, Y. Hashimoto, Y. Honma, I. Arai, and S. Nakaike Modulation of scratching behavior by silencing an endogenous cyclooxygenase-1 gene in the skin through the administration of siRNA J. Gene. Med. 9 2007 994 1001
    • (2007) J. Gene. Med. , vol.9 , pp. 994-1001
    • Inoue, T.1    Sugimoto, M.2    Sakurai, T.3    Saito, R.4    Futaki, N.5    Hashimoto, Y.6    Honma, Y.7    Arai, I.8    Nakaike, S.9
  • 16
    • 0001359591 scopus 로고
    • Introduction of a chimeric chalcone synthase gene into petunia results in reversible co-suppression of homologous genes ín trans
    • C. Napoli, C. Lemieux, and R. Jorgensen Introduction of a chimeric chalcone synthase gene into petunia results in reversible co-suppression of homologous genes ín trans Plant Cell 2 1990
    • (1990) Plant Cell , vol.2
    • Napoli, C.1    Lemieux, C.2    Jorgensen, R.3
  • 19
    • 0031010177 scopus 로고    scopus 로고
    • 2′-O-(2-methoxy)ethyl-modified anti-intercellular adhesion molecule 1 (ICAM-1) oligonucleotides selectively increase the ICAM-1 mRNA level and inhibit formation of the ICAM-1 translation initiation complex in human umbilical vein endothelial cells
    • B.F. Baker 2′-O-(2-methoxy)ethyl-modified anti-intercellular adhesion molecule 1 (ICAM-1) oligonucleotides selectively increase the ICAM-1 mRNA level and inhibit formation of the ICAM-1 translation initiation complex in human umbilical vein endothelial cells J. Biol. Chem. 272 1997 11994 12000
    • (1997) J. Biol. Chem. , vol.272 , pp. 11994-12000
    • Baker, B.F.1
  • 20
    • 0034673638 scopus 로고    scopus 로고
    • An RNA-directed nuclease mediates post-transcriptional gene silencing in drosophila cells
    • S.M. Hammond, E. Bernstein, D. Beach, and G.J. Hannon An RNA-directed nuclease mediates post-transcriptional gene silencing in drosophila cells Nature 404 2000
    • (2000) Nature , vol.404
    • Hammond, S.M.1    Bernstein, E.2    Beach, D.3    Hannon, G.J.4
  • 21
    • 0035905766 scopus 로고    scopus 로고
    • Role for a bidentate ribonuclease in the initiation step of RNA interference
    • E. Bernstein, A.A. Caudy, S.M. Hammond, and G.J. Hannon Role for a bidentate ribonuclease in the initiation step of RNA interference Nature 409 2001
    • (2001) Nature , vol.409
    • Bernstein, E.1    Caudy, A.A.2    Hammond, S.M.3    Hannon, G.J.4
  • 22
    • 3042602447 scopus 로고    scopus 로고
    • Kinetic analysis of the RNAi enzyme complex
    • B. Haley, and P.D. Zamore Kinetic analysis of the RNAi enzyme complex Nat. Struct. Biol. 11 2004 599 606
    • (2004) Nat. Struct. Biol. , vol.11 , pp. 599-606
    • Haley, B.1    Zamore, P.D.2
  • 23
    • 84937515138 scopus 로고    scopus 로고
    • MiRNA inhibition in tissue engineering and regenerative medicine
    • K.R. Beavers, C.E. Nelson, and C.L. Duvall MiRNA inhibition in tissue engineering and regenerative medicine Adv. Drug Deliv. Rev. 88 2014 123 137
    • (2014) Adv. Drug Deliv. Rev. , vol.88 , pp. 123-137
    • Beavers, K.R.1    Nelson, C.E.2    Duvall, C.L.3
  • 25
    • 57349134691 scopus 로고    scopus 로고
    • Chemical modification of siRNAs for in vivo use
    • M.A. Behlke Chemical modification of siRNAs for in vivo use Oligonucleotides 18 2008 305 319
    • (2008) Oligonucleotides , vol.18 , pp. 305-319
    • Behlke, M.A.1
  • 28
  • 29
    • 2442705429 scopus 로고    scopus 로고
    • Small interfering RNAs mediate sequence-independent gene suppression and induce immune activation by signaling through toll-like receptor 3
    • K. Kariko, P. Bhuyan, J. Capodici, and D. Weissman Small interfering RNAs mediate sequence-independent gene suppression and induce immune activation by signaling through toll-like receptor 3 J. Immunol. 172 2004 6545 6549
    • (2004) J. Immunol. , vol.172 , pp. 6545-6549
    • Kariko, K.1    Bhuyan, P.2    Capodici, J.3    Weissman, D.4
  • 31
    • 74049124186 scopus 로고    scopus 로고
    • Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application
    • A.L. Jackson, and P.S. Linsley Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application Nat. Rev. Drug Discov. 9 2010 57 67
    • (2010) Nat. Rev. Drug Discov. , vol.9 , pp. 57-67
    • Jackson, A.L.1    Linsley, P.S.2
  • 33
    • 12844285548 scopus 로고    scopus 로고
    • Overexpression of exportin 5 enhances RNA interference mediated by short hairpin RNAs and microRNAs
    • R. Yi, B.P. Doehle, Y. Qin, I.G. Macara, and B.R. Cullen Overexpression of exportin 5 enhances RNA interference mediated by short hairpin RNAs and microRNAs RNA 11 2005 220 226
    • (2005) RNA , vol.11 , pp. 220-226
    • Yi, R.1    Doehle, B.P.2    Qin, Y.3    Macara, I.G.4    Cullen, B.R.5
  • 37
    • 84906784538 scopus 로고    scopus 로고
    • Controlled release for local delivery of drugs: Barriers and models
    • J.R. Weiser, and W.M. Saltzman Controlled release for local delivery of drugs: barriers and models J. Control Release 190 2014 664 673
    • (2014) J. Control Release , vol.190 , pp. 664-673
    • Weiser, J.R.1    Saltzman, W.M.2
  • 40
    • 1942533474 scopus 로고    scopus 로고
    • In vivo activity of nuclease-resistant siRNAs
    • J.M. Layzer In vivo activity of nuclease-resistant siRNAs RNA 10 2004 766 771
    • (2004) RNA , vol.10 , pp. 766-771
    • Layzer, J.M.1
  • 42
    • 34249947638 scopus 로고    scopus 로고
    • Matrices and scaffolds for DNA delivery in tissue engineering
    • L.D. Laporte, and L.D. Shea Matrices and scaffolds for DNA delivery in tissue engineering Adv. Drug Deliv. Rev. 59 2007
    • (2007) Adv. Drug Deliv. Rev. , vol.59
    • Laporte, L.D.1    Shea, L.D.2
  • 44
    • 33646176224 scopus 로고    scopus 로고
    • How porosity and size affect the drug release mechanisms from PLGA-based microparticles
    • D. Klose, F. Siepmann, K. Elkharraz, S. Krenzlin, and J. Siepmann How porosity and size affect the drug release mechanisms from PLGA-based microparticles Int. J. Pharm. 314 2006 198 206
    • (2006) Int. J. Pharm. , vol.314 , pp. 198-206
    • Klose, D.1    Siepmann, F.2    Elkharraz, K.3    Krenzlin, S.4    Siepmann, J.5
  • 45
  • 46
    • 0035889827 scopus 로고    scopus 로고
    • Smooth muscle cell growth in photopolymerized hydrogels with cell adhesive and proteolytically degradable domains: Synthetic ECM analogs for tissue engineering
    • B.K.G.A. Mann, A.T. Tsai, R.H. Schmelen, and J.L. West Smooth muscle cell growth in photopolymerized hydrogels with cell adhesive and proteolytically degradable domains: synthetic ECM analogs for tissue engineering Biomaterials 22 2001
    • (2001) Biomaterials , vol.22
    • Mann, B.K.G.A.1    Tsai, A.T.2    Schmelen, R.H.3    West, J.L.4
  • 47
    • 0032737267 scopus 로고    scopus 로고
    • Polymeric biomaterials with degradation sites for proteases involved in cell migration
    • J.L. West, and J.A. Hubbell Polymeric biomaterials with degradation sites for proteases involved in cell migration Macromolecules 32 1999
    • (1999) Macromolecules , vol.32
    • West, J.L.1    Hubbell, J.A.2
  • 48
    • 37049029660 scopus 로고    scopus 로고
    • Biomimetic materials for tissue engineering
    • P.X. Ma Biomimetic materials for tissue engineering Adv. Drug. Deliv. Rev. 60 2008 184 198
    • (2008) Adv. Drug. Deliv. Rev. , vol.60 , pp. 184-198
    • Ma, P.X.1
  • 50
    • 21044440000 scopus 로고    scopus 로고
    • Enhanced intracellular uptake and inhibition of NF-κβ activation by decoy oligonucleotide released from PLGA microspheres
    • G. De Rosa, M.C. Maiuri, F. Ungaro, D. De Stefano, F. Quaglia, M.I. La Rotonda, and R. Carnuccio Enhanced intracellular uptake and inhibition of NF-κβ activation by decoy oligonucleotide released from PLGA microspheres J. Gene Med. 7 2005
    • (2005) J. Gene Med. , vol.7
    • De Rosa, G.1    Maiuri, M.C.2    Ungaro, F.3    De Stefano, D.4    Quaglia, F.5    La Rotonda, M.I.6    Carnuccio, R.7
  • 51
    • 33745919229 scopus 로고    scopus 로고
    • BSA degradation under acidic conditions: A model for protein instability during release from PLGA delivery systems
    • T. Estey, J. Kang, S.P. Schwendeman, and J.F. Carpenter BSA degradation under acidic conditions: a model for protein instability during release from PLGA delivery systems J. Pharm. Sci. 95 2006 1626 1639
    • (2006) J. Pharm. Sci. , vol.95 , pp. 1626-1639
    • Estey, T.1    Kang, J.2    Schwendeman, S.P.3    Carpenter, J.F.4
  • 52
    • 79961015788 scopus 로고    scopus 로고
    • In vitro degradation rate of apatitic calcium phosphate cement with incorporated PLGA microspheres
    • R.P. Felix Lanao, S.C. Leeuwenburgh, J.G. Wolke, and J.A. Jansen In vitro degradation rate of apatitic calcium phosphate cement with incorporated PLGA microspheres Acta Biomater. 7 2011 3459 3468
    • (2011) Acta Biomater. , vol.7 , pp. 3459-3468
    • Felix Lanao, R.P.1    Leeuwenburgh, S.C.2    Wolke, J.G.3    Jansen, J.A.4
  • 53
    • 84893810378 scopus 로고    scopus 로고
    • A porous tissue engineering scaffold selectively degraded by cell-generated reactive oxygen species
    • J.R. Martin, M.K. Gupta, J.M. Page, F. Yu, J.M. Davidson, S.A. Guelcher, and C.L. Duvall A porous tissue engineering scaffold selectively degraded by cell-generated reactive oxygen species Biomaterials 35 2014 3766 3776
    • (2014) Biomaterials , vol.35 , pp. 3766-3776
    • Martin, J.R.1    Gupta, M.K.2    Page, J.M.3    Yu, F.4    Davidson, J.M.5    Guelcher, S.A.6    Duvall, C.L.7
  • 54
    • 77958494386 scopus 로고    scopus 로고
    • Orally delivered thioketal nanoparticles loaded with TNF-α-siRNA target inflammation and inhibit gene expression in the intestines
    • D.S. Wilson, G. Dalmasso, L. Wang, S.V. Sitaraman, D. Merlin, and N. Murthy Orally delivered thioketal nanoparticles loaded with TNF-α-siRNA target inflammation and inhibit gene expression in the intestines Nat. Mater. 9 2010
    • (2010) Nat. Mater. , vol.9
    • Wilson, D.S.1    Dalmasso, G.2    Wang, L.3    Sitaraman, S.V.4    Merlin, D.5    Murthy, N.6
  • 55
    • 0036000157 scopus 로고    scopus 로고
    • Surface-tethered DNA complexes for enhanced gene delivery
    • T. Segura, and L.D. Shea Surface-tethered DNA complexes for enhanced gene delivery Bioconjug. Chem. 13 2002
    • (2002) Bioconjug. Chem. , vol.13
    • Segura, T.1    Shea, L.D.2
  • 58
    • 39449097277 scopus 로고    scopus 로고
    • Overcoming the innate immune response to small interfering RNA
    • A. Judge, and I. MacLachlan Overcoming the innate immune response to small interfering RNA Hum. Gene Ther. 19 2008 111 124
    • (2008) Hum. Gene Ther. , vol.19 , pp. 111-124
    • Judge, A.1    MacLachlan, I.2
  • 59
    • 0041331496 scopus 로고    scopus 로고
    • SiRNA function in RNAi: A chemical modification analysis
    • Y.L. Chiu SiRNA function in RNAi: a chemical modification analysis RNA 9 2003 1034 1048
    • (2003) RNA , vol.9 , pp. 1034-1048
    • Chiu, Y.L.1
  • 60
    • 78649659237 scopus 로고    scopus 로고
    • Delivery of siRNA therapeutics: Barriers and carriers
    • J. Wang, Z. Lu, M.G. Wientjes, and J.L. Au Delivery of siRNA therapeutics: barriers and carriers AAPS J. 12 2010 492 503
    • (2010) AAPS J. , vol.12 , pp. 492-503
    • Wang, J.1    Lu, Z.2    Wientjes, M.G.3    Au, J.L.4
  • 63
    • 84856896229 scopus 로고    scopus 로고
    • Amino-modified and lipid-conjugated dicer-substrate siRNA enhances RNAi efficacy
    • T. Kubo, Y. Takei, K. Mihara, K. Yanagihara, and T. Seyama Amino-modified and lipid-conjugated dicer-substrate siRNA enhances RNAi efficacy Bioconjug. Chem. 23 2012 164 173
    • (2012) Bioconjug. Chem. , vol.23 , pp. 164-173
    • Kubo, T.1    Takei, Y.2    Mihara, K.3    Yanagihara, K.4    Seyama, T.5
  • 64
  • 65
    • 72949119713 scopus 로고    scopus 로고
    • Lipidic systems for in vivo siRNA delivery
    • S.Y. Wu, and N.A. McMillan Lipidic systems for in vivo siRNA delivery AAPS J. 11 2009 639 652
    • (2009) AAPS J. , vol.11 , pp. 639-652
    • Wu, S.Y.1    McMillan, N.A.2
  • 69
    • 34848892144 scopus 로고    scopus 로고
    • Cell penetrating peptides: Intracellular pathways and pharmaceutical perspectives
    • L.N. Patel, J.L. Zaro, and W.C. Shen Cell penetrating peptides: intracellular pathways and pharmaceutical perspectives Pharm. Res. 24 2007 1977 1992
    • (2007) Pharm. Res. , vol.24 , pp. 1977-1992
    • Patel, L.N.1    Zaro, J.L.2    Shen, W.C.3
  • 75
    • 19744372388 scopus 로고    scopus 로고
    • Exploring polyethylenimine-mediated DNA transfection and the proton sponge hypothesis
    • A. Akinc, M. Thomas, A.M. Klibanov, and R. Langer Exploring polyethylenimine-mediated DNA transfection and the proton sponge hypothesis J. Gene Med. 7 2005 657 663
    • (2005) J. Gene Med. , vol.7 , pp. 657-663
    • Akinc, A.1    Thomas, M.2    Klibanov, A.M.3    Langer, R.4
  • 76
    • 0035803784 scopus 로고    scopus 로고
    • Histidine-rich peptides and polymers for nucleic acids delivery
    • C. Pichon, C. Goncalves, and P. Midoux Histidine-rich peptides and polymers for nucleic acids delivery Adv. Drug Deliv. Rev. 53 2001
    • (2001) Adv. Drug Deliv. Rev. , vol.53
    • Pichon, C.1    Goncalves, C.2    Midoux, P.3
  • 78
    • 0032473410 scopus 로고    scopus 로고
    • Polylysine-based transfection systems utilizing receptor-mediated delivery
    • W. Zauner, M. Ogris, and E. Wagner Polylysine-based transfection systems utilizing receptor-mediated delivery Adv. Drug Deliv. Rev. 30 1998
    • (1998) Adv. Drug Deliv. Rev. , vol.30
    • Zauner, W.1    Ogris, M.2    Wagner, E.3
  • 82
    • 84879233407 scopus 로고    scopus 로고
    • Matrix metalloproteinase responsive, proximity-activated polymeric nanoparticles for siRNA delivery
    • H. Li, S.S. Yu, M. Miteva, C.E. Nelson, T. Werfel, T.D. Giorgio, and C.L. Duvall Matrix metalloproteinase responsive, proximity-activated polymeric nanoparticles for siRNA delivery Adv. Funct. Mater. 23 2013 3040 3052
    • (2013) Adv. Funct. Mater. , vol.23 , pp. 3040-3052
    • Li, H.1    Yu, S.S.2    Miteva, M.3    Nelson, C.E.4    Werfel, T.5    Giorgio, T.D.6    Duvall, C.L.7
  • 83
    • 84887003262 scopus 로고    scopus 로고
    • Balancing cationic and hydrophobic content of pegylated siRNA polyplexes enhances endosome escape, stability, blood circulation time, and bioactivity in vivo
    • C.E. Nelson, R.J. Kintzing, A. Hanna, J.M. Shannon, M.K. Gupta, and C.L. Duvall Balancing cationic and hydrophobic content of pegylated siRNA polyplexes enhances endosome escape, stability, blood circulation time, and bioactivity in vivo ACS Nano 7 2013 8870 8880
    • (2013) ACS Nano , vol.7 , pp. 8870-8880
    • Nelson, C.E.1    Kintzing, R.J.2    Hanna, A.3    Shannon, J.M.4    Gupta, M.K.5    Duvall, C.L.6
  • 87
    • 84906670921 scopus 로고    scopus 로고
    • Catch and release: Photocleavable cationic diblock copolymers as a potential platform for nucleic acid delivery
    • M.D. Green, A.A. Foster, C.T. Greco, R. Roy, R.M. Lehr, T.H. Epps III, and M.O. Sullivan Catch and release: photocleavable cationic diblock copolymers as a potential platform for nucleic acid delivery Polym. Chem. 5 2014
    • (2014) Polym. Chem. , vol.5
    • Green, M.D.1    Foster, A.A.2    Greco, C.T.3    Roy, R.4    Lehr, R.M.5    Epps, T.H.6    Sullivan, M.O.7
  • 88
    • 84899434779 scopus 로고    scopus 로고
    • Bioreducible cationic polymer-based nanoparticles for efficient and environmentally triggered cytoplasmic siRNA delivery to primary human brain cancer cells
    • K.L. Kozielski, S.Y. Tzeng, B.A. Hurtado De Mendoza, and J.J. Green Bioreducible cationic polymer-based nanoparticles for efficient and environmentally triggered cytoplasmic siRNA delivery to primary human brain cancer cells ACS Nano 8 2015
    • (2015) ACS Nano , vol.8
    • Kozielski, K.L.1    Tzeng, S.Y.2    Hurtado De Mendoza, B.A.3    Green, J.J.4
  • 89
    • 84889666512 scopus 로고    scopus 로고
    • Spatially controlled delivery of siRNAs to stem cells in implants generated by multi-component additive manufacturing
    • M.Ø. Andersen, D.Q.S. Le, M. Chen, J.V. Nygaard, M. Kassem, C. Bünger, and J. Kjems Spatially controlled delivery of siRNAs to stem cells in implants generated by multi-component additive manufacturing Adv. Funct. Mater. 23 2013 5599 5607
    • (2013) Adv. Funct. Mater. , vol.23 , pp. 5599-5607
    • Andersen, M.Ø.1    Le, D.Q.S.2    Chen, M.3    Nygaard, J.V.4    Kassem, M.5    Bünger, C.6    Kjems, J.7
  • 90
    • 77952672525 scopus 로고    scopus 로고
    • RNA interference by nanofiber-based siRNA delivery system
    • H. Cao, X. Jiang, C. Chai, and S.Y. Chew RNA interference by nanofiber-based siRNA delivery system J. Control Release 144 2010 203 212
    • (2010) J. Control Release , vol.144 , pp. 203-212
    • Cao, H.1    Jiang, X.2    Chai, C.3    Chew, S.Y.4
  • 91
    • 67749108284 scopus 로고    scopus 로고
    • Layer-by-layer assembly of all carbon nanotube ultrathin films for electrochemical applications
    • S.W.K.B. Lee, S. Chen, Y. Shao-Horn, and P.T. Hammond Layer-by-layer assembly of all carbon nanotube ultrathin films for electrochemical applications J. Am. Chem. Soc. 131 2008 671 679
    • (2008) J. Am. Chem. Soc. , vol.131 , pp. 671-679
    • Lee, S.W.K.B.1    Chen, S.2    Shao-Horn, Y.3    Hammond, P.T.4
  • 92
    • 0036011284 scopus 로고    scopus 로고
    • Controlled release of NFκβ decoy oligonucleotides from biodegradable polymer microparticles
    • X. Zhu, L. Lu, B.L. Currier, A.J. Windebank, and M.J. Yaszemski Controlled release of NFκβ decoy oligonucleotides from biodegradable polymer microparticles Biomaterials 23 2002
    • (2002) Biomaterials , vol.23
    • Zhu, X.1    Lu, L.2    Currier, B.L.3    Windebank, A.J.4    Yaszemski, M.J.5
  • 93
    • 79959915001 scopus 로고    scopus 로고
    • Controlled release of anti-inflammatory siRNA from biodegradable polymeric microparticles intended for intra-articular delivery to the temporomandibular joint
    • P.M. Mountziaris, D.C. Sing, S.A. Chew, S.N. Tzouanas, E.D. Lehman, F.K. Kasper, and A.G. Mikos Controlled release of anti-inflammatory siRNA from biodegradable polymeric microparticles intended for intra-articular delivery to the temporomandibular joint Pharm. Res. 28 2011 1370 1384
    • (2011) Pharm. Res. , vol.28 , pp. 1370-1384
    • Mountziaris, P.M.1    Sing, D.C.2    Chew, S.A.3    Tzouanas, S.N.4    Lehman, E.D.5    Kasper, F.K.6    Mikos, A.G.7
  • 94
    • 0031689425 scopus 로고    scopus 로고
    • Development of a sustained-release biodegradable polymer delivery system for site-specific delivery of oligonucleotides: Characterization of p(LA-GA) copolymer microspheres in vitro
    • S.J. Lewis, W.J. Irwin, and S. Akhtar Development of a sustained-release biodegradable polymer delivery system for site-specific delivery of oligonucleotides: characterization of p(LA-GA) copolymer microspheres in vitro J. Drug Targets 5 1998
    • (1998) J. Drug Targets , vol.5
    • Lewis, S.J.1    Irwin, W.J.2    Akhtar, S.3
  • 95
    • 0030919006 scopus 로고    scopus 로고
    • Antisense oligonucleotide delivery to cultured macrophages is improved by incorporation into sustained-release biodegradablepolymer microspheres
    • S. Akhtar, and K.J. Lewis Antisense oligonucleotide delivery to cultured macrophages is improved by incorporation into sustained-release biodegradablepolymer microspheres Int. J. Pharm. 151 1997
    • (1997) Int. J. Pharm. , vol.151
    • Akhtar, S.1    Lewis, K.J.2
  • 96
    • 84899489828 scopus 로고    scopus 로고
    • The effect of combined IL10 siRNA and CPG ODN as pathogen-mimicking microparticles on TH1/TH2 cytokine balance in dendritic cells and protective immunity against B cell lymphoma
    • P. Pradhan, H. Qin, J.A. Leleux, D. Gwak, I. Sakamaki, L.W. Kwak, and K. Roy The effect of combined IL10 siRNA and CPG ODN as pathogen-mimicking microparticles on TH1/TH2 cytokine balance in dendritic cells and protective immunity against B cell lymphoma Biomaterials 35 2014 5491 5504
    • (2014) Biomaterials , vol.35 , pp. 5491-5504
    • Pradhan, P.1    Qin, H.2    Leleux, J.A.3    Gwak, D.4    Sakamaki, I.5    Kwak, L.W.6    Roy, K.7
  • 97
    • 67849084830 scopus 로고    scopus 로고
    • In-situ crosslinking hydrogels for combinatorial delivery of chemokines and siRNA-DNA carrying microparticles to dendritic cells
    • A. Singh, S. Suri, and K. Roy In-situ crosslinking hydrogels for combinatorial delivery of chemokines and siRNA-DNA carrying microparticles to dendritic cells Biomaterials 30 2009 5187 5200
    • (2009) Biomaterials , vol.30 , pp. 5187-5200
    • Singh, A.1    Suri, S.2    Roy, K.3
  • 98
    • 84865514367 scopus 로고    scopus 로고
    • Intra-articular controlled release of anti-inflammatory siRNA with biodegradable polymer microparticles ameliorates temporomandibular joint inflammation
    • P.M. Mountziaris, S.N. Tzouanas, D.C. Sing, P.R. Kramer, F.K. Kasper, and A.G. Mikos Intra-articular controlled release of anti-inflammatory siRNA with biodegradable polymer microparticles ameliorates temporomandibular joint inflammation Acta Biomater. 8 2012 3552 3560
    • (2012) Acta Biomater. , vol.8 , pp. 3552-3560
    • Mountziaris, P.M.1    Tzouanas, S.N.2    Sing, D.C.3    Kramer, P.R.4    Kasper, F.K.5    Mikos, A.G.6
  • 99
    • 66249146049 scopus 로고    scopus 로고
    • Complexity in biomaterials for tissue engineering
    • E.S. Place, N.D. Evans, and M.M. Stevens Complexity in biomaterials for tissue engineering Nat. Mater. 8 2009
    • (2009) Nat. Mater. , vol.8
    • Place, E.S.1    Evans, N.D.2    Stevens, M.M.3
  • 100
    • 72449211810 scopus 로고    scopus 로고
    • Snail1 down-regulation using small interfering RNA complexes delivered through collagen scaffolds
    • R. Vinas-Castells, C. Holladay, A. di Luca, V.M. Diaz, and A. Pandit Snail1 down-regulation using small interfering RNA complexes delivered through collagen scaffolds Bioconjug. Chem. 20 2009
    • (2009) Bioconjug. Chem. , vol.20
    • Vinas-Castells, R.1    Holladay, C.2    Di Luca, A.3    Diaz, V.M.4    Pandit, A.5
  • 101
    • 77956615316 scopus 로고    scopus 로고
    • Gene delivery by surface immobilization of plasmid to tissue-engineering scaffolds
    • D.M. Salvay, M. Zelivyanskaya, and L.D. Shea Gene delivery by surface immobilization of plasmid to tissue-engineering scaffolds Gene Ther. 17 2010 1134 1141
    • (2010) Gene Ther. , vol.17 , pp. 1134-1141
    • Salvay, D.M.1    Zelivyanskaya, M.2    Shea, L.D.3
  • 102
    • 39649102638 scopus 로고    scopus 로고
    • Biodegradable polyurethanes: Synthesis and applications in regenerative medicine
    • S.A. Guelcher Biodegradable polyurethanes: synthesis and applications in regenerative medicine Tissue Eng. Part B Rev. 14 2008 3 17
    • (2008) Tissue Eng. Part B Rev. , vol.14 , pp. 3-17
    • Guelcher, S.A.1
  • 103
    • 51649125144 scopus 로고    scopus 로고
    • Injectable biodegradable polyurethane scaffolds with release of platelet-derived growth factor for tissue repair and regeneration
    • A.E. Hafeman, B. Li, T. Yoshii, K. Zienkiewicz, J.M. Davidson, and S.A. Guelcher Injectable biodegradable polyurethane scaffolds with release of platelet-derived growth factor for tissue repair and regeneration Pharm. Res. 25 2008 2387 2399
    • (2008) Pharm. Res. , vol.25 , pp. 2387-2399
    • Hafeman, A.E.1    Li, B.2    Yoshii, T.3    Zienkiewicz, K.4    Davidson, J.M.5    Guelcher, S.A.6
  • 104
    • 77954309514 scopus 로고    scopus 로고
    • Sustained release of vancomycin from polyurethane scaffolds inhibits infection of bone wounds in a rat femoral segmental defect model
    • B. Li, K.V. Brown, J.C. Wenke, and S.A. Guelcher Sustained release of vancomycin from polyurethane scaffolds inhibits infection of bone wounds in a rat femoral segmental defect model J. Control Release 145 2010 221 230
    • (2010) J. Control Release , vol.145 , pp. 221-230
    • Li, B.1    Brown, K.V.2    Wenke, J.C.3    Guelcher, S.A.4
  • 105
    • 79960922709 scopus 로고    scopus 로고
    • Hyaluronic acid and fibrin hydrogels with concentrated DNA/pei polyplexes for local gene delivery
    • Y. Lei, M. Rahim, Q. Ng, and T. Segura Hyaluronic acid and fibrin hydrogels with concentrated DNA/pei polyplexes for local gene delivery J. Control Release 153 2011 255 261
    • (2011) J. Control Release , vol.153 , pp. 255-261
    • Lei, Y.1    Rahim, M.2    Ng, Q.3    Segura, T.4
  • 107
    • 77957312459 scopus 로고    scopus 로고
    • Incorporation of active DNA/cationic polymer polyplexes into hydrogel scaffolds
    • Y. Lei, S. Huang, P. Sharif-Kashani, Y. Chen, P. Kavehpour, and T. Segura Incorporation of active DNA/cationic polymer polyplexes into hydrogel scaffolds Biomaterials 31 2010 9106 9116
    • (2010) Biomaterials , vol.31 , pp. 9106-9116
    • Lei, Y.1    Huang, S.2    Sharif-Kashani, P.3    Chen, Y.4    Kavehpour, P.5    Segura, T.6
  • 109
    • 79957907735 scopus 로고    scopus 로고
    • Nanofiber-mediated controlled release of siRNA complexes for long term gene-silencing applications
    • P.O. Rujitanaroj, Y.C. Wang, J. Wang, and S.Y. Chew Nanofiber-mediated controlled release of siRNA complexes for long term gene-silencing applications Biomaterials 32 2011 5915 5923
    • (2011) Biomaterials , vol.32 , pp. 5915-5923
    • Rujitanaroj, P.O.1    Wang, Y.C.2    Wang, J.3    Chew, S.Y.4
  • 110
    • 67649948772 scopus 로고    scopus 로고
    • Localized and sustained delivery of silencing RNA from macroscopic biopolymer hydrogels
    • M.D. Krebs, O. Jeon, and E. Alsberg Localized and sustained delivery of silencing RNA from macroscopic biopolymer hydrogels J. Am. Chem. Soc. 131 2009
    • (2009) J. Am. Chem. Soc. , vol.131
    • Krebs, M.D.1    Jeon, O.2    Alsberg, E.3
  • 111
    • 84870241193 scopus 로고    scopus 로고
    • Functionalized, biodegradable hydrogels for control over sustained and localized siRNA delivery to incorporated and surrounding cells
    • K. Nguyen, P.N. Dang, and E. Alsberg Functionalized, biodegradable hydrogels for control over sustained and localized siRNA delivery to incorporated and surrounding cells Acta Biomater. 9 2013 4487 4495
    • (2013) Acta Biomater. , vol.9 , pp. 4487-4495
    • Nguyen, K.1    Dang, P.N.2    Alsberg, E.3
  • 112
    • 84889666512 scopus 로고    scopus 로고
    • Spatially controlled delivery of siRNAs to stem cells in implants generated by multi-component additive manufacturing
    • M.Ø. Andersen, D.Q.S. Le, M. Chen, J.V. Nygaard, M. Kassem, C. Bünger, and J. Kjems Spatially controlled delivery of siRNAs to stem cells in implants generated by multi-component additive manufacturing Adv Funct Mater. 23 2013 5599 5607
    • (2013) Adv Funct Mater. , vol.23 , pp. 5599-5607
    • Andersen, M.Ø.1    Le, D.Q.S.2    Chen, M.3    Nygaard, J.V.4    Kassem, M.5    Bünger, C.6    Kjems, J.7
  • 113
    • 84876173876 scopus 로고    scopus 로고
    • Synthesis and fabrication of a degradable poly(n-isopropyl acrylamide) scaffold for tissue engineering applications
    • A. Galperin, T.J. Long, S. Garty, and B.D. Ratner Synthesis and fabrication of a degradable poly(n-isopropyl acrylamide) scaffold for tissue engineering applications J. Biomed. Mater. Res. A. 101 2013 775 786
    • (2013) J. Biomed. Mater. Res. A. , vol.101 , pp. 775-786
    • Galperin, A.1    Long, T.J.2    Garty, S.3    Ratner, B.D.4
  • 114
    • 84908431032 scopus 로고    scopus 로고
    • Cell protective, ABC triblock polymer-based thermoresponsive hydrogels with ROS-triggered degradation and drug release
    • M.K. Gupta, J.R. Martin, T.A. Werfel, T. Shen, J.M. Page, and C.L. Duvall Cell protective, ABC triblock polymer-based thermoresponsive hydrogels with ROS-triggered degradation and drug release J. Am. Chem. Soc. 136 2014 14896 14902
    • (2014) J. Am. Chem. Soc. , vol.136 , pp. 14896-14902
    • Gupta, M.K.1    Martin, J.R.2    Werfel, T.A.3    Shen, T.4    Page, J.M.5    Duvall, C.L.6
  • 115
    • 84879887394 scopus 로고    scopus 로고
    • Dual pH- and temperature-responsive microparticles for protein delivery to ischemic tissues
    • R.V. Joshi, C.E. Nelson, K.M. Poole, M.C. Skala, and C.L. Duvall Dual pH- and temperature-responsive microparticles for protein delivery to ischemic tissues Acta Biomater. 9 2013 6526 6534
    • (2013) Acta Biomater. , vol.9 , pp. 6526-6534
    • Joshi, R.V.1    Nelson, C.E.2    Poole, K.M.3    Skala, M.C.4    Duvall, C.L.5
  • 116
    • 77955148833 scopus 로고    scopus 로고
    • Thermally responsive injectable hydrogel incorporating methacrylate-polylactide for hydrolytic lability
    • Z. Ma, D.M. Nelson, Y. Hong, and W.R. Wagner Thermally responsive injectable hydrogel incorporating methacrylate-polylactide for hydrolytic lability Biomacromolecules 11 2010 1873 1881
    • (2010) Biomacromolecules , vol.11 , pp. 1873-1881
    • Ma, Z.1    Nelson, D.M.2    Hong, Y.3    Wagner, W.R.4
  • 117
    • 84893322819 scopus 로고    scopus 로고
    • Hydrogel-nanoparticle composites for optically modulated cancer therapeutic delivery
    • L.E. Strong, S.N. Dahotre, and J.L. West Hydrogel-nanoparticle composites for optically modulated cancer therapeutic delivery J. Control Release 178 2014 63 68
    • (2014) J. Control Release , vol.178 , pp. 63-68
    • Strong, L.E.1    Dahotre, S.N.2    West, J.L.3
  • 119
    • 84929192704 scopus 로고    scopus 로고
    • Dual stimuli-responsive redox-active injectable gel by polyion complex based flower micelles for biomedical applications
    • S. Ishii, J. Kaneko, and Y. Nagasaki Dual stimuli-responsive redox-active injectable gel by polyion complex based flower micelles for biomedical applications Macromolecules 48 2015 3088 3094
    • (2015) Macromolecules , vol.48 , pp. 3088-3094
    • Ishii, S.1    Kaneko, J.2    Nagasaki, Y.3
  • 121
    • 84875607485 scopus 로고    scopus 로고
    • An injectable cell penetrable nano-polyplex hydrogel for localized siRNA delivery
    • Y.M. Kim, M.R. Park, and S.C. Song An injectable cell penetrable nano-polyplex hydrogel for localized siRNA delivery Biomaterials 34 2013 4493 4500
    • (2013) Biomaterials , vol.34 , pp. 4493-4500
    • Kim, Y.M.1    Park, M.R.2    Song, S.C.3
  • 122
    • 84899569836 scopus 로고    scopus 로고
    • Patterned substrates of nano-graphene oxide mediating highly localized and efficient gene delivery
    • K. Li, L. Feng, J. Shen, Q. Zhang, Z. Liu, S.T. Lee, and J. Liu Patterned substrates of nano-graphene oxide mediating highly localized and efficient gene delivery ACS Appl. Mater. Int. 6 2014 5900 5907
    • (2014) ACS Appl. Mater. Int. , vol.6 , pp. 5900-5907
    • Li, K.1    Feng, L.2    Shen, J.3    Zhang, Q.4    Liu, Z.5    Lee, S.T.6    Liu, J.7
  • 123
    • 84891736128 scopus 로고    scopus 로고
    • Tunable staged release of therapeutics from layer-by-layer coatings with clay interlayer barrier
    • J. Min, R.D. Braatz, and P.T. Hammond Tunable staged release of therapeutics from layer-by-layer coatings with clay interlayer barrier Biomaterials 35 2014 2507 2517
    • (2014) Biomaterials , vol.35 , pp. 2507-2517
    • Min, J.1    Braatz, R.D.2    Hammond, P.T.3
  • 124
    • 74049110958 scopus 로고    scopus 로고
    • MAD (multiagent delivery) nanolayer: Delivering multiple therapeutics from hierarchically assembled surface coatings
    • B.S. Kim, R.C. Smith, Z. Poon, and P.T. Hammond MAD (multiagent delivery) nanolayer: delivering multiple therapeutics from hierarchically assembled surface coatings Langmuir 25 2009 14086 14092
    • (2009) Langmuir , vol.25 , pp. 14086-14092
    • Kim, B.S.1    Smith, R.C.2    Poon, Z.3    Hammond, P.T.4
  • 125
    • 84856204235 scopus 로고    scopus 로고
    • Graphene multilayers as gates for multi-week sequential release of proteins from surfaces
    • J.S.N. Hong, A.C. Drake, P.C. DeMuth, J.B. Lee, J. Chen, and P.T. Hammond Graphene multilayers as gates for multi-week sequential release of proteins from surfaces ACS Nano 6 2012
    • (2012) ACS Nano , vol.6
    • Hong, J.S.N.1    Drake, A.C.2    DeMuth, P.C.3    Lee, J.B.4    Chen, J.5    Hammond, P.T.6
  • 126
    • 84879643385 scopus 로고    scopus 로고
    • Nanolayered siRNA dressing for sustained localized knockdown
    • S. Castleberry, M. Wang, and P.T. Hammond Nanolayered siRNA dressing for sustained localized knockdown ACS Nano. 7 2013
    • (2013) ACS Nano. , vol.7
    • Castleberry, S.1    Wang, M.2    Hammond, P.T.3
  • 131
    • 80054692841 scopus 로고    scopus 로고
    • Vaginal delivery of siRNA using a novel PEGylated lipoplex-entrapped alginate scaffold system
    • S.Y. Wu, H.I. Chang, M. Burgess, and N.A. McMillan Vaginal delivery of siRNA using a novel PEGylated lipoplex-entrapped alginate scaffold system J. Control Release 155 2011 418 426
    • (2011) J. Control Release , vol.155 , pp. 418-426
    • Wu, S.Y.1    Chang, H.I.2    Burgess, M.3    McMillan, N.A.4
  • 138
    • 84921748939 scopus 로고    scopus 로고
    • Hydrogel doped with nanoparticles for local sustained release of siRNA in breast cancer
    • N. Segovia, M. Pont, N. Oliva, V. Ramos, S. Borros, and N. Artzi Hydrogel doped with nanoparticles for local sustained release of siRNA in breast cancer Adv. Healthc Mater. 4 2015 271 280
    • (2015) Adv. Healthc Mater. , vol.4 , pp. 271-280
    • Segovia, N.1    Pont, M.2    Oliva, N.3    Ramos, V.4    Borros, S.5    Artzi, N.6
  • 139
    • 80054083256 scopus 로고    scopus 로고
    • Local delivery of siRNA using a biodegradable polymer application to enhance BMP-induced bone formation
    • T. Manaka, A. Suzuki, K. Takayama, Y. Imai, H. Nakamura, and K. Takaoka Local delivery of siRNA using a biodegradable polymer application to enhance BMP-induced bone formation Biomaterials 32 2011 9642 9648
    • (2011) Biomaterials , vol.32 , pp. 9642-9648
    • Manaka, T.1    Suzuki, A.2    Takayama, K.3    Imai, Y.4    Nakamura, H.5    Takaoka, K.6
  • 140
    • 84870239023 scopus 로고    scopus 로고
    • Controlling fibrous capsule formation through long-term down-regulation of collagen type I (COL1a1) expression by nanofiber-mediated siRNA gene silencing
    • P.O. Rujitanaroj, B. Jao, J. Yang, F. Wang, J.M. Anderson, J. Wang, and S.Y. Chew Controlling fibrous capsule formation through long-term down-regulation of collagen type I (COL1a1) expression by nanofiber-mediated siRNA gene silencing Acta Biomater. 9 2013 4513 4524
    • (2013) Acta Biomater. , vol.9 , pp. 4513-4524
    • Rujitanaroj, P.O.1    Jao, B.2    Yang, J.3    Wang, F.4    Anderson, J.M.5    Wang, J.6    Chew, S.Y.7
  • 148
    • 84878063536 scopus 로고    scopus 로고
    • Local applications of myostatin-siRNA with atelocollagen increase skeletal muscle mass and recovery of muscle function
    • E. Kawakami, N. Kawai, N. Kinouchi, H. Mori, Y. Ohsawa, N. Ishimaru, Y. Sunada, S. Noji, and E. Tanaka Local applications of myostatin-siRNA with atelocollagen increase skeletal muscle mass and recovery of muscle function PloS One 8 2013 e64719
    • (2013) PloS One , vol.8
    • Kawakami, E.1    Kawai, N.2    Kinouchi, N.3    Mori, H.4    Ohsawa, Y.5    Ishimaru, N.6    Sunada, Y.7    Noji, S.8    Tanaka, E.9
  • 150
    • 38949205532 scopus 로고    scopus 로고
    • Suppression of early experimental osteoarthritis by in vivo delivery of the adenoviral vector-mediated nf-kappabp65-specific siRNA
    • L.X. Chen, L. Lin, H.J. Wang, X.L. Wei, X. Fu, J.Y. Zhang, and C.L. Yu Suppression of early experimental osteoarthritis by in vivo delivery of the adenoviral vector-mediated nf-kappabp65-specific siRNA Osteoarthr. Cartilage 16 2008 174 184
    • (2008) Osteoarthr. Cartilage , vol.16 , pp. 174-184
    • Chen, L.X.1    Lin, L.2    Wang, H.J.3    Wei, X.L.4    Fu, X.5    Zhang, J.Y.6    Yu, C.L.7
  • 151
    • 79959882942 scopus 로고    scopus 로고
    • Localized delivery of antisense oligonucleotides by cationic hydrogel suppresses TNF-alpha expression and endotoxin-induced osteolysis
    • L. Dong, Z. Huang, X. Cai, J. Xiang, Y.A. Zhu, R. Wang, J. Chen, and J. Zhang Localized delivery of antisense oligonucleotides by cationic hydrogel suppresses TNF-alpha expression and endotoxin-induced osteolysis Pharm. Res. 28 2011 1349 1356
    • (2011) Pharm. Res. , vol.28 , pp. 1349-1356
    • Dong, L.1    Huang, Z.2    Cai, X.3    Xiang, J.4    Zhu, Y.A.5    Wang, R.6    Chen, J.7    Zhang, J.8
  • 153
    • 84876116755 scopus 로고    scopus 로고
    • Protective effect of lentivirus-mediated siRNA targeting ADAMTS-5 on cartilage degradation in a rat model of osteoarthritis
    • X. Chu, H. You, X. Yuan, W. Zhao, W. Li, and X. Guo Protective effect of lentivirus-mediated siRNA targeting ADAMTS-5 on cartilage degradation in a rat model of osteoarthritis Int. J. Mol. Med. 31 2013 1222 1228
    • (2013) Int. J. Mol. Med. , vol.31 , pp. 1222-1228
    • Chu, X.1    You, H.2    Yuan, X.3    Zhao, W.4    Li, W.5    Guo, X.6
  • 154
    • 84930483467 scopus 로고    scopus 로고
    • Intra-articular delivery of anti-HIF-2alpha siRNA by chondrocyte-homing nanoparticles to prevent cartilage degeneration in arthritic mice
    • Y. Pi, X. Zhang, Z. Shao, F. Zhao, X. Hu, and Y. Ao Intra-articular delivery of anti-HIF-2alpha siRNA by chondrocyte-homing nanoparticles to prevent cartilage degeneration in arthritic mice Gene Ther. 22 2015 439 448
    • (2015) Gene Ther. , vol.22 , pp. 439-448
    • Pi, Y.1    Zhang, X.2    Shao, Z.3    Zhao, F.4    Hu, X.5    Ao, Y.6
  • 155
    • 34248225758 scopus 로고    scopus 로고
    • Cellular and molecular basis of wound healing in diabetes
    • H. Brem, and M. Tomic-Canic Cellular and molecular basis of wound healing in diabetes J. Clin. Invest. 117 2007 1219 1222
    • (2007) J. Clin. Invest. , vol.117 , pp. 1219-1222
    • Brem, H.1    Tomic-Canic, M.2
  • 156
    • 84886750021 scopus 로고    scopus 로고
    • Non-viral DNA delivery from porous hyaluronic acid hydrogels in mice
    • T. Tokatlian, C. Cam, and T. Segura Non-viral DNA delivery from porous hyaluronic acid hydrogels in mice Biomaterials 35 2014 825 835
    • (2014) Biomaterials , vol.35 , pp. 825-835
    • Tokatlian, T.1    Cam, C.2    Segura, T.3
  • 157
    • 23844480941 scopus 로고    scopus 로고
    • Plasmid delivery in vivo from porous tissue-engineering scaffolds: Transgene expression and cellular transfection
    • J.H. Jang, C.B. Rives, and L.D. Shea Plasmid delivery in vivo from porous tissue-engineering scaffolds: transgene expression and cellular transfection Mol. Ther. 12 2005 475 483
    • (2005) Mol. Ther. , vol.12 , pp. 475-483
    • Jang, J.H.1    Rives, C.B.2    Shea, L.D.3
  • 158
    • 68949099629 scopus 로고    scopus 로고
    • VEGF therapy: A timely retreat
    • A. Alfranca VEGF therapy: a timely retreat Cardiovasc. Res. 83 2009 611 612
    • (2009) Cardiovasc. Res. , vol.83 , pp. 611-612
    • Alfranca, A.1
  • 159
    • 84883780219 scopus 로고    scopus 로고
    • Enhancing microvascular formation and vessel maturation through temporal control over multiple pro-angiogenic and pro-maturation factors
    • Y. Brudno, A.B. Ennett-Shepard, R.R. Chen, M. Aizenberg, and D.J. Mooney Enhancing microvascular formation and vessel maturation through temporal control over multiple pro-angiogenic and pro-maturation factors Biomaterials 34 2013 9201 9209
    • (2013) Biomaterials , vol.34 , pp. 9201-9209
    • Brudno, Y.1    Ennett-Shepard, A.B.2    Chen, R.R.3    Aizenberg, M.4    Mooney, D.J.5
  • 160
    • 34249306597 scopus 로고    scopus 로고
    • Regulation and guidance of cell behavior for tissue regeneration via the siRNA mechanism
    • S.K. Cheema, E. Chen, L.D. Shea, and A.B. Mathur Regulation and guidance of cell behavior for tissue regeneration via the siRNA mechanism Wound Repair Regen. 15 2007 286 295
    • (2007) Wound Repair Regen. , vol.15 , pp. 286-295
    • Cheema, S.K.1    Chen, E.2    Shea, L.D.3    Mathur, A.B.4
  • 161
    • 85047682984 scopus 로고    scopus 로고
    • Regulation of oxygen homeostasis by hypoxia-inducible factor 1
    • G.L. Semenza Regulation of oxygen homeostasis by hypoxia-inducible factor 1 Physiology 24 2009 97 106
    • (2009) Physiology , vol.24 , pp. 97-106
    • Semenza, G.L.1
  • 162
    • 84857458226 scopus 로고    scopus 로고
    • Prolyl hydroxylase inhibitors increase the production of vascular endothelial growth factor by periodontal fibroblasts
    • H. Agis, G. Watzek, and R. Gruber Prolyl hydroxylase inhibitors increase the production of vascular endothelial growth factor by periodontal fibroblasts J. Periodontal Res. 47 2012 165 173
    • (2012) J. Periodontal Res. , vol.47 , pp. 165-173
    • Agis, H.1    Watzek, G.2    Gruber, R.3
  • 166
    • 14544297836 scopus 로고    scopus 로고
    • RNA interference targeting transforming growth factor-β type II receptor suppresses ocular inflammation and fibrosis
    • H. Nakamura, S.S. Siddiqui, X. Shen, A.B. Malik, J.S. Pulido, N.M. Kumar, and B.Y. Yue RNA interference targeting transforming growth factor-β type II receptor suppresses ocular inflammation and fibrosis Mol. Vis. 10 2004
    • (2004) Mol. Vis. , vol.10
    • Nakamura, H.1    Siddiqui, S.S.2    Shen, X.3    Malik, A.B.4    Pulido, J.S.5    Kumar, N.M.6    Yue, B.Y.7
  • 167
    • 84894472709 scopus 로고    scopus 로고
    • Triple combination of siRNAs targeting TGFbeta1, TGFbetaR2, and CTGF enhances reduction of collagen I and smooth muscle actin in corneal fibroblasts
    • S. Sriram, P. Robinson, L. Pi, A.S. Lewin, and G. Schultz Triple combination of siRNAs targeting TGFbeta1, TGFbetaR2, and CTGF enhances reduction of collagen I and smooth muscle actin in corneal fibroblasts Invest. Ophthalmol. Vis. Sci. 54 2013 8214 8223
    • (2013) Invest. Ophthalmol. Vis. Sci. , vol.54 , pp. 8214-8223
    • Sriram, S.1    Robinson, P.2    Pi, L.3    Lewin, A.S.4    Schultz, G.5
  • 168
    • 84894074911 scopus 로고    scopus 로고
    • Erk2 small interfering RNAs prevent epidural fibrosis via the efficient inhibition of collagen expression and inflammation in laminectomy rats
    • C. Zhang, X. Kong, C. Liu, Z. Liang, H. Zhao, W. Tong, G. Ning, W. Shen, L. Yao, and S. Feng Erk2 small interfering RNAs prevent epidural fibrosis via the efficient inhibition of collagen expression and inflammation in laminectomy rats Biochem. Biophys. Res. Commun. 444 2014 395 400
    • (2014) Biochem. Biophys. Res. Commun. , vol.444 , pp. 395-400
    • Zhang, C.1    Kong, X.2    Liu, C.3    Liang, Z.4    Zhao, H.5    Tong, W.6    Ning, G.7    Shen, W.8    Yao, L.9    Feng, S.10
  • 169
    • 78049478521 scopus 로고    scopus 로고
    • Device-based local delivery of siRNA against mammalian target of rapamycin (mTOR) in a murine subcutaneous implant model to inhibit fibrous encapsulation
    • H. Takahashi, Y. Wang, and D.W. Grainger Device-based local delivery of siRNA against mammalian target of rapamycin (mTOR) in a murine subcutaneous implant model to inhibit fibrous encapsulation J. Control Release 147 2010 400 407
    • (2010) J. Control Release , vol.147 , pp. 400-407
    • Takahashi, H.1    Wang, Y.2    Grainger, D.W.3
  • 172
    • 70350142394 scopus 로고    scopus 로고
    • An immobilized nanoparticle-based platform for efficient gene knockdown of targeted cells in the circulation
    • Z. Huang, and M.R. King An immobilized nanoparticle-based platform for efficient gene knockdown of targeted cells in the circulation Gene Ther. 16 2009 1271 1282
    • (2009) Gene Ther. , vol.16 , pp. 1271-1282
    • Huang, Z.1    King, M.R.2
  • 173
    • 9644291513 scopus 로고    scopus 로고
    • Long-term patency of saphenous vein and left internal mammary artery grafts after coronary artery bypass surgery: Results from a department of veterans affairs cooperative study
    • S. Goldman, K. Zadina, T. Moritz, T. Ovitt, G. Sethi, J.G. Copeland, L. Thottapurathu, B. Krasnicka, N. Ellis, R.J. Anderson, W. Henderson, and V.A.C.S. Group Long-term patency of saphenous vein and left internal mammary artery grafts after coronary artery bypass surgery: results from a department of veterans affairs cooperative study J. Am. Coll. Cardiol. 44 2004 2149 2156
    • (2004) J. Am. Coll. Cardiol. , vol.44 , pp. 2149-2156
    • Goldman, S.1    Zadina, K.2    Moritz, T.3    Ovitt, T.4    Sethi, G.5    Copeland, J.G.6    Thottapurathu, L.7    Krasnicka, B.8    Ellis, N.9    Anderson, R.J.10    Henderson, W.11
  • 176
    • 0036851826 scopus 로고    scopus 로고
    • Vascular proliferation and atherosclerosis: New perspectives and therapeutic strategies
    • V.J.R.C. Dzau, and D.G. Sedding Vascular proliferation and atherosclerosis: new perspectives and therapeutic strategies Nat. Med. 8 2002
    • (2002) Nat. Med. , vol.8
    • Dzau, V.J.R.C.1    Sedding, D.G.2
  • 177
    • 84895016937 scopus 로고    scopus 로고
    • Gene silencing in human aortic smooth muscle cells induced by pei-siRNA complexes released from dip-coated electrospun poly(ethylene terephthalate) grafts
    • C.S. Nabzdyk, M.C. Chun, H.S. Oliver-Allen, S.G. Pathan, M.D. Phaneuf, J.O. You, L.K. Pradhan-Nabzdyk, and F.W. LoGerfo Gene silencing in human aortic smooth muscle cells induced by pei-siRNA complexes released from dip-coated electrospun poly(ethylene terephthalate) grafts Biomaterials 35 2014 3071 3079
    • (2014) Biomaterials , vol.35 , pp. 3071-3079
    • Nabzdyk, C.S.1    Chun, M.C.2    Oliver-Allen, H.S.3    Pathan, S.G.4    Phaneuf, M.D.5    You, J.O.6    Pradhan-Nabzdyk, L.K.7    LoGerfo, F.W.8
  • 179
    • 66249083866 scopus 로고    scopus 로고
    • Intravaginal gene silencing using biodegradable polymer nanoparticles densely loaded with small-interfering RNA
    • K.A. Woodrow, Y. Cu, C.J. Booth, J.K. Saucier-Sawyer, M.J. Wood, and W.M. Saltzman Intravaginal gene silencing using biodegradable polymer nanoparticles densely loaded with small-interfering RNA Nat. Mater. 8 2009
    • (2009) Nat. Mater. , vol.8
    • Woodrow, K.A.1    Cu, Y.2    Booth, C.J.3    Saucier-Sawyer, J.K.4    Wood, M.J.5    Saltzman, W.M.6
  • 180
    • 84864262905 scopus 로고    scopus 로고
    • Injectable polyplex hydrogel for localized and long-term delivery of siRNA
    • Y. Kim, M. Park, and S. Song Injectable polyplex hydrogel for localized and long-term delivery of siRNA ACS Nano 6 2012
    • (2012) ACS Nano , vol.6
    • Kim, Y.1    Park, M.2    Song, S.3
  • 182
    • 84906938439 scopus 로고    scopus 로고
    • Oncogenic kras signalling in pancreatic cancer
    • S. Eser, A. Schnieke, G. Schneider, and D. Saur Oncogenic kras signalling in pancreatic cancer Br. J. Cancer 111 2014 817 822
    • (2014) Br. J. Cancer , vol.111 , pp. 817-822
    • Eser, S.1    Schnieke, A.2    Schneider, G.3    Saur, D.4
  • 183
    • 40449092256 scopus 로고    scopus 로고
    • Controlled delivery of T-box21 small interfering RNA ameliorates autoimmune alopecia (alopecia areata) in a C3H/HEJ mouse model
    • M. Nakamura, J. Jo, Y. Tabata, and O. Ishikawa Controlled delivery of T-box21 small interfering RNA ameliorates autoimmune alopecia (alopecia areata) in a C3H/HEJ mouse model Am. J. Pathol. 172 2008 650 658
    • (2008) Am. J. Pathol. , vol.172 , pp. 650-658
    • Nakamura, M.1    Jo, J.2    Tabata, Y.3    Ishikawa, O.4
  • 184
    • 45749085675 scopus 로고    scopus 로고
    • Topical application of cream-emulsified CD86 siRNA ameliorates allergic skin disease by targeting cutaneous dendritic cells
    • P. Ritprajak, M. Hashiguchi, and M. Azuma Topical application of cream-emulsified CD86 siRNA ameliorates allergic skin disease by targeting cutaneous dendritic cells Mol. Ther. 16 2008 1323 1330
    • (2008) Mol. Ther. , vol.16 , pp. 1323-1330
    • Ritprajak, P.1    Hashiguchi, M.2    Azuma, M.3
  • 185
    • 69949136638 scopus 로고    scopus 로고
    • Connective tissue growth factor: Growth factor, matricellular organizer, fibrotic biomarker or molecular target for anti-fibrotic therapy in SSC?
    • D. Abraham Connective tissue growth factor: growth factor, matricellular organizer, fibrotic biomarker or molecular target for anti-fibrotic therapy in SSC? Rheumatology 47 Suppl. 5 2008 v8 v9
    • (2008) Rheumatology , vol.47 , pp. v8-v9
    • Abraham, D.1
  • 187
    • 84903816671 scopus 로고    scopus 로고
    • Angiogenic/osteogenic response of bmmscs on bone-derived scaffold: Effect of hypoxia and role of PI3K/AKT-mediated VEGF-VEGFR pathway
    • Y. Zhou, X. Guan, M. Yu, X. Wang, W. Zhu, C. Wang, M. Yu, and H. Wang Angiogenic/osteogenic response of bmmscs on bone-derived scaffold: effect of hypoxia and role of PI3K/AKT-mediated VEGF-VEGFR pathway Biotechnol. J. 9 2014 944 953
    • (2014) Biotechnol. J. , vol.9 , pp. 944-953
    • Zhou, Y.1    Guan, X.2    Yu, M.3    Wang, X.4    Zhu, W.5    Wang, C.6    Yu, M.7    Wang, H.8
  • 188
    • 84903449853 scopus 로고    scopus 로고
    • Targetable micelleplex hydrogel for long-term, effective, and systemic siRNA delivery
    • Y.M. Kim, and S.C. Song Targetable micelleplex hydrogel for long-term, effective, and systemic siRNA delivery Biomaterials. 35 2014 7970 7977
    • (2014) Biomaterials. , vol.35 , pp. 7970-7977
    • Kim, Y.M.1    Song, S.C.2
  • 189
    • 84906334255 scopus 로고    scopus 로고
    • Cancer-specific gene silencing through therapeutic siRNA delivery with B vitamin-based nanoassembled low-molecular-weight hydrogelators
    • S.P. Patil, S.H. Kim, J.R. Jadhav, J.H. Lee, E.M. Jeon, K.T. Kim, and B.H. Kim Cancer-specific gene silencing through therapeutic siRNA delivery with B vitamin-based nanoassembled low-molecular-weight hydrogelators Bioconjug. Chem. 2014
    • (2014) Bioconjug. Chem.
    • Patil, S.P.1    Kim, S.H.2    Jadhav, J.R.3    Lee, J.H.4    Jeon, E.M.5    Kim, K.T.6    Kim, B.H.7
  • 191
    • 84902553548 scopus 로고    scopus 로고
    • Tumor targeting RGD conjugated bio-reducible polymer for VEGF siRNA expressing plasmid delivery
    • H.A. Kim, K. Nam, and S.W. Kim Tumor targeting RGD conjugated bio-reducible polymer for VEGF siRNA expressing plasmid delivery Biomaterials 35 2014 7543 7552
    • (2014) Biomaterials , vol.35 , pp. 7543-7552
    • Kim, H.A.1    Nam, K.2    Kim, S.W.3
  • 195
    • 84877130036 scopus 로고    scopus 로고
    • Clinical development of synthetic siRNA therapeutics
    • J.D. Thompson Clinical development of synthetic siRNA therapeutics Drug Discov. Today 10 2013 e133 e138
    • (2013) Drug Discov. Today , vol.10 , pp. e133-e138
    • Thompson, J.D.1
  • 197
    • 84862317270 scopus 로고    scopus 로고
    • RNA interference trigger variants: Getting the most out of RNA for RNA interference-based therapeutics
    • N.M. Snead, and J.J. Rossi RNA interference trigger variants: getting the most out of RNA for RNA interference-based therapeutics Nucleic Acid Ther. 22 2012 139 146
    • (2012) Nucleic Acid Ther. , vol.22 , pp. 139-146
    • Snead, N.M.1    Rossi, J.J.2
  • 198
    • 1242297011 scopus 로고    scopus 로고
    • Intravitreal injection of vascular endothelial growth factor small interfering RNA inhibits growth and leakage in a nonhuman primate, laser-induced model of choroidal neovascularization
    • M.J. Tolentino, A.J. Brucker, J. Fosnot, G.S. Ying, I.H. Wu, G. Malik, S. Wan, and S.J. Reich Intravitreal injection of vascular endothelial growth factor small interfering RNA inhibits growth and leakage in a nonhuman primate, laser-induced model of choroidal neovascularization Retina-J. Ret. Vit. Dis. 24 2004
    • (2004) Retina-J. Ret. Vit. Dis. , vol.24
    • Tolentino, M.J.1    Brucker, A.J.2    Fosnot, J.3    Ying, G.S.4    Wu, I.H.5    Malik, G.6    Wan, S.7    Reich, S.J.8
  • 199
    • 44949220320 scopus 로고    scopus 로고
    • Ocular biodistribution of bevasiranib following a single intravitreal injection to rabbit eyes
    • N.S. Dejneka, S. Wan, O.S. Bond, D.J. Kornbrust, and S.J. Reich Ocular biodistribution of bevasiranib following a single intravitreal injection to rabbit eyes Mol Vis. 14 2008
    • (2008) Mol Vis. , vol.14
    • Dejneka, N.S.1    Wan, S.2    Bond, O.S.3    Kornbrust, D.J.4    Reich, S.J.5
  • 217
    • 84891834550 scopus 로고    scopus 로고
    • Phase I clinical trial of SYL040012, a small interfering RNA targeting beta-adrenergic receptor 2, for lowering intraocular pressure
    • J. Moreno-Montanes, B. Sadaba, V. Ruz, A. Gomez-Guiu, J. Zarranz, M.V. Gonzalez, C. Paneda, and A.I. Jimenez Phase I clinical trial of SYL040012, a small interfering RNA targeting beta-adrenergic receptor 2, for lowering intraocular pressure Mol. Ther. 22 2014 226 232
    • (2014) Mol. Ther. , vol.22 , pp. 226-232
    • Moreno-Montanes, J.1    Sadaba, B.2    Ruz, V.3    Gomez-Guiu, A.4    Zarranz, J.5    Gonzalez, M.V.6    Paneda, C.7    Jimenez, A.I.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.