Controlled release of anti-inflammatory siRNA from biodegradable polymeric microparticles intended for intra-articular delivery to the temporomandibular joint

Pharmaceutical Research

Volumn 28, Issue 6, 2011, Pages 1370-1384

  Mountziaris, Paschalia M ^a   Sing, David C ^a   Chew, Sue Anne ^a   Tzouanas, Stephanie N ^a   Lehman, E Dennis ^a   Kasper, F Kurtis ^a   Mikos, Antonios G ^a  

^a Rice University   (United States)

Author keywords

intra articular; microparticle; polyplex; temporomandibular joint

Indexed keywords

NITROGEN; PHOSPHATE; PHOSPHATE BUFFERED SALINE; POLYETHYLENEIMINE; POLYGLACTIN; POLYLACTIC ACID; POLYMER; SILENCER; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTHRITIS; ARTICLE; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; DISSOCIATION; DRUG STABILITY; EMULSION; ENCAPSULATION; IN VITRO STUDY; IN VIVO STUDY; KNEE DISEASE; LIGHT SCATTERING; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PARTICLE SIZE; PH; PRIORITY JOURNAL; RAT; SUSTAINED RELEASE PREPARATION; TEMPOROMANDIBULAR JOINT; TEMPOROMANDIBULAR JOINT DISORDER;

ABSORBABLE IMPLANTS; ANTI-INFLAMMATORY AGENTS; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; EMULSIONS; HYDROGEN-ION CONCENTRATION; IMINES; INJECTIONS, INTRA-ARTICULAR; KINETICS; LACTIC ACID; MICROSPHERES; OSTEITIS; PARTICLE SIZE; POLYETHYLENES; POLYGLYCOLIC ACID; RNA, SMALL INTERFERING; TEMPOROMANDIBULAR JOINT;

EID: 79959915001     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-010-0354-9     Document Type: Article

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