Tuning PEGylation of mixed micelles to overcome intracellular and systemic siRNA delivery barriers

Biomaterials

Volumn 38, Issue , 2015, Pages 97-107

  Miteva, Martina ^a   Kirkbride, Kellye C ^a   Kilchrist, Kameron V ^a   Werfel, Thomas A ^a   Li, Hongmei ^a   Nelson, Christopher E ^a   Gupta, Mukesh K ^a   Giorgio, Todd D ^a   Duvall, Craig L ^a  

^a VANDERBILT UNIVERSITY   (United States)

Author keywords

FRET imaging; Intracellular drug release; Mixed micelles; Nanoparticle PEGylation; Pharmacokinetics; SiRNA

Indexed keywords

BIOCHEMISTRY; CARDIOVASCULAR SYSTEM; ETHYLENE; ETHYLENE GLYCOL; ISOMERS; MOLECULAR WEIGHT; PHARMACOKINETICS; RNA;

BUTYL METHACRYLATES; CELLULAR INTERNALIZATION; DIMETHYLAMINOETHYL METHACRYLATES; DRUG RELEASE; INVERSE RELATIONSHIP; MIXED MICELLES; PEGYLATION; SIRNA;

MICELLES;

POLYMER; SMALL INTERFERING RNA; BUTYL METHACRYLATE; MACROGOL DERIVATIVE; METHACRYLIC ACID DERIVATIVE; MICELLE; NANOCAPSULE;

ARTICLE; BREAST CANCER CELL LINE; CHEMICAL REACTION; CIRCULATION; CONTROLLED STUDY; DENSITY; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG HALF LIFE; DRUG POTENCY; GENE SILENCING; IN VIVO STUDY; INTERNALIZATION; MICELLE; MOLECULAR WEIGHT; PEGYLATION; QUANTITATIVE ANALYSIS; SURFACE PROPERTY; ZETA POTENTIAL; ANIMAL; BAGG ALBINO MOUSE; BLOOD; CELL FRACTIONATION; CHEMISTRY; DIFFUSION; DRUG FORMULATION; HUMAN; METABOLISM; MOUSE; PARTICLE SIZE; PROCEDURES; ULTRASTRUCTURE;

ANIMALS; DIFFUSION; DRUG COMPOUNDING; HUMANS; METHACRYLATES; MICE; MICE, INBRED BALB C; MICELLES; NANOCAPSULES; PARTICLE SIZE; POLYETHYLENE GLYCOLS; RNA, SMALL INTERFERING; SUBCELLULAR FRACTIONS;

EID: 84912080933     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2014.10.036     Document Type: Article

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