An in situ gelling liquid crystalline system based on monoglycerides and polyethylenimine for local delivery of siRNAs

European Journal of Pharmaceutical Sciences

Volumn 74, Issue , 2015, Pages 103-117

  Borgheti Cardoso, Lívia Neves ^a   Depieri, Lívia Vieira ^a   Kooijmans, Sander A A ^b   Diniz, Henrique ^a   Calzzani, Ricardo Alexandre Junqueira ^c   De Carvalho Vicentini, Fabiana Testa Moura ^a   Van Der Meel, Roy ^b   De Abreu Fantini, Márcia Carvalho ^a   Iyomasa, Mamie Mizusaki ^a   Schiffelers, Raymond M ^b   Bentley, Maria Vitória Lopes Badra ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c UNIVERSIDAD DE LA FRONTERA   (Chile)

Author keywords

Liquid crystal; Local release; Non viral gene delivery; Self assembly; siRNA

Indexed keywords

MONOACYLGLYCEROL; POLYETHYLENEIMINE; PROPYLENE GLYCOL; SMALL INTERFERING RNA; ACYLGLYCEROL; GEL; GLYCEROL OLEATE; VISCOELASTIC SUBSTANCE; WATER;

ARTICLE; BIOCOMPATIBILITY; BIREFRINGENCE; DRUG RELEASE; FEMALE; IN VITRO STUDY; MICROSCOPY; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; WATER ABSORPTION; WATER TRANSPORT; X RAY CRYSTALLOGRAPHY; ADVERSE EFFECTS; ANIMAL; BAGG ALBINO MOUSE; CELLULITIS; CHEMICALLY INDUCED; CHEMISTRY; COMPARATIVE STUDY; DRUG EFFECTS; GEL; GENE TRANSFER; IMMUNOLOGY; PATHOLOGY; RNA INTERFERENCE; RNAI THERAPEUTICS; SKIN; SOLUBILITY; SUBCUTANEOUS DRUG ADMINISTRATION; SUBCUTANEOUS TISSUE; VISCOSITY;

ANIMALS; CELLULITIS; FEMALE; GELS; GENE TRANSFER TECHNIQUES; GLYCERIDES; INJECTIONS, SUBCUTANEOUS; MICE, INBRED BALB C; MONOGLYCERIDES; POLYETHYLENEIMINE; PROPYLENE GLYCOL; RNA INTERFERENCE; RNA, SMALL INTERFERING; RNAI THERAPEUTICS; SKIN; SOLUBILITY; SUBCUTANEOUS TISSUE; VISCOELASTIC SUBSTANCES; VISCOSITY; WATER;

EID: 84929992170     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2015.04.017     Document Type: Article

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