Localized delivery of antisense oligonucleotides by cationic hydrogel suppresses TNF-α expression and endotoxin-induced osteolysis

Pharmaceutical Research

Volumn 28, Issue 6, 2011, Pages 1349-1356

  Dong, Lei ^a   Huang, Zhen ^a   Cai, Xing ^a   Xiang, Jiawei ^a   Zhu, Yi An ^a   Wang, Rui ^a   Chen, Jiangning ^a   Zhang, Junfeng ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

antisense; localized gene delivery; osteolysis; TNF

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CHITOSAN; ENDOTOXIN; GELATIN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; ISIS 25302; OSTEOCLAST DIFFERENTIATION FACTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE DISEASE; CALVARIA; CELL ADHESION; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; EXTRACELLULAR MATRIX; FEMALE; HYDROGEL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; OSTEOCLASTOGENESIS; OSTEOLYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SCANNING ELECTRON MICROSCOPY; UPREGULATION;

ANIMALS; CATIONS; CHITOSAN; DRUG DELIVERY SYSTEMS; ENDOTOXINS; FEMALE; GELATIN; GENE THERAPY; GENE TRANSFER TECHNIQUES; HYDROGEL; MICE; MICE, INBRED C57BL; OLIGONUCLEOTIDES, ANTISENSE; OSTEOGENESIS; OSTEOLYSIS; RATS; RATS, SPRAGUE-DAWLEY; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79959882942     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-010-0334-0     Document Type: Article

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