Controlled release for local delivery of drugs: Barriers and models

Journal of Controlled Release

Volumn 190, Issue , 2014, Pages 664-673

  Weiser, Jennifer R ^a   Saltzman, W Mark ^a  

^a Yale University   (United States)

Author keywords

Controlled release; Local delivery; Pharmacokinetics; Polymer systems; Wound healing

Indexed keywords

BLOOD VESSELS; DIFFUSION BARRIERS; ORGANIC POLYMERS; PHARMACOKINETICS; TARGETED DRUG DELIVERY; TISSUE; MATHEMATICAL MODELS;

CONTROLLED RELEASE; CONTROLLED RELEASE SYSTEMS; LOCAL DELIVERY; LOCAL DRUG DELIVERY; POLYMER SYSTEMS; SYSTEMIC TOXICITIES; THERAPEUTIC LEVELS; WOUND HEALING;

CONTROLLED DRUG DELIVERY;

ARTICLE; COMPARTMENT MODEL; CONTROLLED DRUG RELEASE; DIFFUSION; DISPERSION; DRUG DELIVERY DEVICE; DRUG ELIMINATION; DRUG METABOLISM; DRUG PENETRATION; DRUG TARGETING; DRUG TRANSPORT; HUMAN; MATHEMATICAL MODEL; MOLECULAR DYNAMICS; MUCOSA; NONHUMAN; PRIORITY JOURNAL; SKIN; STEADY STATE; THERMODYNAMICS; AUTORADIOGRAPHY; BINDING AFFINITY; CELL MEMBRANE; CHEMICAL STRUCTURE; CONTROLLED RELEASE FORMULATION; DRUG DIFFUSION; DRUG DISTRIBUTION; DRUG ELUTING STENT; DRUG IMPLANT; DRUG TISSUE LEVEL; EXTRACELLULAR SPACE; FEMALE GENITAL SYSTEM; GASTROINTESTINAL TRACT; INTRACELLULAR SPACE; LOCAL THERAPY; MUCUS; RESPIRATORY EPITHELIUM; REVIEW; SKIN PENETRATION; STRATUM CORNEUM; SUBCUTANEOUS TISSUE; TISSUE DISTRIBUTION; VAGINA MUCOSA; VAGINA RING; BIOLOGICAL MODEL; BRAIN; CHEMICAL MODEL; DELAYED RELEASE FORMULATION; DRUG DELIVERY SYSTEM; METABOLISM; PHARMACOKINETICS; SKIN ABSORPTION;

CARMUSTINE; ETHINYLESTRADIOL PLUS ETONOGESTREL; PILOCARPINE; PROGESTERONE; DELAYED RELEASE FORMULATION;

BRAIN; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; HUMANS; MODELS, BIOLOGICAL; MODELS, CHEMICAL; SKIN ABSORPTION;

EID: 84906784538     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.04.048     Document Type: Review

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