Prolonged gene silencing in hepatoma cells and primary hepatocytes after small interfering RNA delivery with biodegradable poly(β-amino esters)

Journal of Gene Medicine

Volumn 10, Issue 7, 2008, Pages 783-794

  Vandenbroucke, Roosmarijn E ^a   De Geest, Bruno G ^a   Bonné, Stefan ^b   Vinken, Mathieu ^b   Van Haecke, Tamara ^b   Heimberg, Harry ^b   Wagner, Ernst ^c   Rogiers, Vera ^b   De Smedt, Stefaan C ^a   Demeester, Joseph ^a   Sanders, Niek N ^a  

^a GHENT UNIVERSITY   (Belgium)

^b VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^c UNIVERSITY OF MUNICH   (Germany)

Author keywords

Biodegradable polymer; Liver cells; Poly( amino esters); Prolonged gene silencing; siRNA delivery

Indexed keywords

1,4 BUTANEDIOL POLYDIACRYLIC ACID; 1,6 HEXANEDIOL POLYDIACRYLIC ACID; POLY(BETA AMINO ESTER DERIVATIVE); POLYAMINE DERIVATIVE; POLYMER; SMALL INTERFERING RNA;

ARTICLE; BIODEGRADABILITY; CELL DIVISION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOTOXICITY; DRUG RELEASE; ENDOSOME; GENE SILENCING; GENE TARGETING; GENETIC TRANSFECTION; HEPATOMA CELL; HUMAN; HUMAN CELL; HYDROLYSIS; LIVER CELL; NONVIRAL GENE DELIVERY SYSTEM; OSMOTIC PRESSURE; PRIORITY JOURNAL; TUMOR CELL;

ADENOVIRIDAE; ANIMALS; BUTYLENE GLYCOLS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; ESTERS; GENE SILENCING; GENE THERAPY; GENE TRANSFER TECHNIQUES; GLYCOLS; HEPATOCYTES; HUMANS; MICROSCOPY, CONFOCAL; MOLECULAR STRUCTURE; POLYMERS; RATS; RNA, SMALL INTERFERING;

EID: 48949120120     PISSN: 1099498X     EISSN: 15212254     Source Type: Journal    
DOI: 10.1002/jgm.1202     Document Type: Article

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