Balancing cationic and hydrophobic content of PEGylated siRNA polyplexes enhances endosome escape, stability, blood circulation time, and bioactivity in vivo

ACS Nano

Volumn 7, Issue 10, 2013, Pages 8870-8880

  Nelson, Christopher E ^a   Kintzing, James R ^a   Hanna, Ann ^a   Shannon, Joshua M ^a   Gupta, Mukesh K ^a   Duvall, Craig L ^a  

^a VANDERBILT UNIVERSITY   (United States)

Author keywords

drug delivery; endosomal escape; intravenous delivery; PEG; reversible addition fragmentation chain transfer (RAFT) polymerization; siRNA; smart polymer

Indexed keywords

ENDOSOMAL ESCAPES; INTRAVENOUS DELIVERY; REVERSIBLE ADDITION-FRAGMENTATION CHAIN TRANSFER POLYMERIZATION; SIRNA; SMART POLYMERS;

CARDIOVASCULAR SYSTEM; DRUG DELIVERY; HYDROPHOBICITY; POLYETHYLENE GLYCOLS;

POLYMERS;

CATION; MACROGOL DERIVATIVE; SMALL INTERFERING RNA;

ARTICLE; CHEMICAL PHENOMENA; CHEMISTRY; CIRCULATION; ENDOSOME; HALF LIFE TIME; HUMAN; METABOLISM; TISSUE DISTRIBUTION; TUMOR CELL LINE;

BLOOD CIRCULATION; CATIONS; CELL LINE, TUMOR; ENDOSOMES; HALF-LIFE; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; POLYETHYLENE GLYCOLS; RNA, SMALL INTERFERING; TISSUE DISTRIBUTION;

EID: 84887003262     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn403325f     Document Type: Article

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