How porosity and size affect the drug release mechanisms from PLGA-based microparticles

International Journal of Pharmaceutics

Volumn 314, Issue 2, 2006, Pages 198-206

  Klose, D ^a,b   Siepmann, F ^b   Elkharraz, K ^a   Krenzlin, S ^b   Siepmann, J ^a,b  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b UNIV LILLE   (France)

Author keywords

Autocatalysis; Controlled release; Microparticle; PLGA; Porosity

Indexed keywords

LIDOCAINE; OIL; PHOSPHATE; POLYGLACTIN; POLYMER; RESOMER; WATER;

ARTICLE; CHEMICAL COMPOSITION; DEGRADATION; DEVICE; DIFFERENTIAL SCANNING CALORIMETRY; DIFFUSION; DRUG RELEASE; EMULSION; EVAPORATION; EXPOSURE; GEL PERMEATION CHROMATOGRAPHY; GRAVIMETRY; MEASUREMENT; MICROSCOPY; PARTICLE SIZE; PH MEASUREMENT; PHYSICAL CHEMISTRY; POROSITY; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; SOLVENT EXTRACTION; TRANSPORT KINETICS;

CATALYSIS; DRUG CARRIERS; KINETICS; LACTIC ACID; LIDOCAINE; MICROSPHERES; MODELS, CHEMICAL; PARTICLE SIZE; POLYGLYCOLIC ACID; POLYMERS; POROSITY; SOLUBILITY; SURFACE PROPERTIES; TECHNOLOGY, PHARMACEUTICAL;

EID: 33646176224     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2005.07.031     Document Type: Article

References (19)

1. Benoit J.P., Faisant N., Venier-Julienne M.C., and Menei P. Development of microspheres for neurological disorders: from basics to clinical applications. J. Control. Rel. 65 (2000) 285-296
2. Brunner A., Mäder K., and Göpferich A. pH and osmotic pressure inside biodegradable microspheres during erosion. Pharm. Res. 16 (1999) 847-853
3. Charlier A., Leclerc B., and Couarraze G. Release of mifepristone from biodegradable matrices: experimental and theoretical evaluations. Int. J. Pharm. 200 (2000) 115-120
4. Dunne M., Corrigan O.I., and Ramtoola Z. Influence of particle size and dissolution conditions on the degradation properties of polylactide-co-glycolide particles. Biomaterials 21 (2000) 1659-1668
5. Faisant N., Siepmann J., and Benoit J.P. PLGA-based microparticles: elucidation of mechanisms and a new, simple mathematical model quantifying drug release. Eur. J. Pharm. Sci. 15 (2002) 355-366
6. Fan L.T., and Singh S.K. Controlled Release: A Quantitative Treatment (1989), Springer-Verlag, Berlin
7. Fournier E., Passirani C., Montero-Menei C.N., and Benoit J.P. Biocompatibility of implantable synthetic polymeric drug carriers: focus on brain biocompatibility. Biomaterials 24 (2003) 3311-3331
8. Grayson A.C.R., Cima M.J., and Langer R. Size and temperature effects on poly(lactic-co-glycolic acid) degradation and microreservoir device performance. Biomaterials 26 (2005) 2137-2145
9. Grizzi I., Garreau S.L., and Vert M. Hydrolytic degradation of devices based on poly(dl-lactic acid) size-dependence. Biomaterials 16 (1995) 305-311
10. 2 and sucrose on the stability of bovine serum albumin encapsulated in injectable poly(d,l-lactide-co-glycolide) implants. Biomaterials 23 (2002) 239-245
11. Kenley R.A., Lee M.O., Mahoney T.R., and Sanders L.M. Poly(lactide-co-glycolide) decomposition kinetics in vivo and in vitro. Macromolecules 20 (1987) 2398-2403
12. Li L., and Schwendeman S.P. Mapping neutral microclimate pH in PLGA microspheres. J. Control. Rel. 101 (2005) 163-173
13. Lu L., Garcia C.A., and Mikos A.G. In vitro degradation of thin poly(d,l-lactic-co-glycolic acid) films. J. Biomed. Mater. Res. 46 (1999) 236-244
14. Raman C., Berkland C., Kim K.K., and Pack D.W. Modeling small-molecule release from PLG microspheres: effects of polymer degradation and non-uniform drug distribution. J. Control. Rel. 103 (2005) 149-158
15. Ravivarapu H.B., Burton K., and DeLuca P.P. Polymer and microsphere blending to alter the release of a peptide from PLGA microspheres. Eur. J. Pharm. Biopharm. 50 (2000) 263-270
16. Siepmann J., and Göpferich A. Mathematical modeling of bioerodible, polymeric drug delivery systems. Adv. Drug Del. Rev. 48 (2001) 229-247
17. Siepmann J., Faisant N., and Benoit J.P. A new mathematical model quantifying drug release from bioerodible microparticles using Monte Carlo simulations. Pharm. Res. 19 (2002) 1885-1893
18. Siepmann J., Elkharraz K., Siepmann F., and Klose D. How autocatalysis accelerates drug release from PLGA-based microparticles: A quantitative treatment. Biomacromolecules 6 (2005) 2312-2319
19. von Burkersroda F., Schedl L., and Göpferich A. Why degradable polymers undergo surface erosion or bulk erosion. Biomaterials 23 (2002) 4221-4231