Bioreducible cationic polymer-based nanoparticles for efficient and environmentally triggered cytoplasmic siRNA delivery to primary human brain cancer cells

ACS Nano

Volumn 8, Issue 4, 2014, Pages 3232-3241

  Kozielski, Kristen L ^a   Tzeng, Stephany Y ^a   Hurtado De Mendoza, Bolivia A ^a   Green, Jordan J ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

cancer; drug delivery; nanomedicine; nanoparticle; polymer; siRNA

Indexed keywords

CELLS; CHEMICAL MODIFICATION; CYTOLOGY; DRUG DELIVERY; GENES; LIPOSOMES; MEDICAL NANOTECHNOLOGY; MOLECULAR BIOLOGY; NANOPARTICLES; RNA; SYNTHESIS (CHEMICAL);

AQUEOUS CONDITION; CANCER; GLIOBLASTOMA CELLS; NEURAL PROGENITOR CELLS; POLYMER PROPERTIES; POLYMERIC NANOPARTICLES; REDUCING ENVIRONMENT; SIRNA;

POLYMERS;

DRUG CARRIER; NANOPARTICLE; POLY(BETA-AMINO ESTER); POLYMER; SMALL INTERFERING RNA;

BRAIN TUMOR; CELL SURVIVAL; CHEMISTRY; CYTOSOL; DRUG EFFECTS; DRUG RELEASE; GENETIC TRANSFECTION; GENETICS; HUMAN; METABOLISM; NUCLEOTIDE SEQUENCE; OXIDATION REDUCTION REACTION; PARTICLE SIZE; PATHOLOGY; SAFETY; TUMOR CELL LINE;

BASE SEQUENCE; BRAIN NEOPLASMS; CELL LINE, TUMOR; CELL SURVIVAL; CYTOSOL; DRUG CARRIERS; DRUG LIBERATION; HUMANS; NANOPARTICLES; OXIDATION-REDUCTION; PARTICLE SIZE; POLYMERS; RNA, SMALL INTERFERING; SAFETY; TRANSFECTION;

EID: 84899434779     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn500704t     Document Type: Article

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