Injectable polyplex hydrogel for localized and long-term delivery of siRNA

ACS Nano

Volumn 6, Issue 7, 2012, Pages 5757-5766

  Kim, Young Min ^a,b   Park, Mi Ran ^a   Song, Soo Chang ^a,b  

^a Korea Institute of Science and Technology   (South Korea)

^b University of Science and Technology (UST)   (South Korea)

Author keywords

injectable polyplex hydrogel; local delivery; long term therapy; siRNA; sustained polyplex release

Indexed keywords

ANTITUMOR EFFECT; BODY TEMPERATURE; CATIONIC POLYMERS; CELL CYCLE; ESTER LINKAGES; GENE SILENCING; HYDROPHOBIC INTERACTIONS; IN-VIVO; LOCAL DELIVERY; LONG-TERM THERAPY; LOW MOLECULAR WEIGHT; POLYPLEXES; SHORT INTERFERING RNA (SIRNA); SIRNA; THERMO SENSITIVE; THERMOSENSITIVITIES; TUMOR XENOGRAFTS;

BIODEGRADATION; DEGRADATION; DYES; GENE THERAPY; GENETIC ENGINEERING; RNA;

HYDROGELS;

CYCLIN B1; NANOCONJUGATE; ORGANOPHOSPHORUS COMPOUND; POLY(ORGANOPHOSPHAZENE); POLYETHYLENEIMINE; POLYMER; SMALL INTERFERING RNA;

ANIMAL; ARTICLE; CHEMISTRY; DELAYED RELEASE FORMULATION; DRUG ANTAGONISM; DRUG DELIVERY SYSTEM; DRUG SCREENING; GENE SILENCING; GENETICS; HUMAN; HYDROGEL; INJECTION; MALE; MOLECULAR WEIGHT; MOUSE; NANOTECHNOLOGY; NUDE MOUSE; PARTICLE SIZE; PHASE TRANSITION; SYNTHESIS; TUMOR CELL LINE; VISCOSITY;

ANIMALS; CELL LINE, TUMOR; CYCLIN B1; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; GENE SILENCING; HUMANS; HYDROGELS; INJECTIONS; MALE; MICE; MICE, NUDE; MOLECULAR WEIGHT; NANOCONJUGATES; NANOTECHNOLOGY; ORGANOPHOSPHORUS COMPOUNDS; PARTICLE SIZE; PHASE TRANSITION; POLYETHYLENEIMINE; POLYMERS; RNA, SMALL INTERFERING; VISCOSITY; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84864262905     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn300842a     Document Type: Article

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