Localized and sustained delivery of silencing RNA from macroscopic biopolymer hydrogels

Journal of the American Chemical Society

Volumn 131, Issue 26, 2009, Pages 9204-9206

  Krebs, Melissa D ^a   Jeon, Oju ^a   Alsberg, Eben ^a,b  

^a Case Western Reserve University   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CROSSLINKED; DEGRADABLE BIOMATERIALS; DELIVERY VEHICLE; GENE SILENCING; HYDROGEL SCAFFOLDS; IN-CELL; IN-VIVO; LOCALIZED DELIVERY; MINIMALLY INVASIVE; MRNA MOLECULES; POST-TRANSCRIPTIONAL; REGENERATIVE MEDICINE; RNA INTERFERENCE; SHORT INTERFERING RNA (SIRNA); SHORT-TERM EFFECTS; SITE OF INTERESTS; THERAPEUTIC TOOLS; TRANSPLANTED CELLS;

BIOLOGICAL MATERIALS; BIOMOLECULES; CALCIUM; CELL CULTURE; CELL MEMBRANES; CELL PROLIFERATION; GENETIC ENGINEERING; NUCLEIC ACIDS; RNA; TRANSCRIPTION;

HYDROGELS;

BIOPOLYMER; CALCIUM ALGINATE; GREEN FLUORESCENT PROTEIN; MESSENGER RNA; SMALL INTERFERING RNA;

ARTICLE; CELL STRAIN HEK293; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HYDROGEL; PROTEIN EXPRESSION; RNA INTERFERENCE;

ALGINATES; CELL LINE; COLLAGEN; DELAYED-ACTION PREPARATIONS; DIFFUSION; GENES, REPORTER; GLUCURONIC ACID; GREEN FLUORESCENT PROTEINS; HEXURONIC ACIDS; HUMANS; HYDROGELS; KIDNEY; RNA INTERFERENCE; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 67649948772     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja9037615     Document Type: Article

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