Modulation of scratching behavior by silencing an endogenous cyclooxygenase-1 gene in the skin through the administration of siRNA

Journal of Gene Medicine

Volumn 9, Issue 11, 2007, Pages 994-1001

  Inoue, Tomoyuki ^a   Sugimoto, Masanori ^a   Sakurai, Takanobu ^a   Saito, Rie ^a   Futaki, Nobuko ^a   Hashimoto, Yuki ^a   Honma, Yusuke ^a   Arai, Iwao ^a   Nakaike, Shiro ^a  

^a TAISHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Atopic dermatitis; COX 1; Electroporation; In vivo; Scratching; siRNA

Indexed keywords

5 (4 CHLOROPHENYL) 1 (4 METHOXYPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOLE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; PROSTAGLANDIN; SMALL INTERFERING RNA;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATOPIC DERMATITIS; CONTROLLED STUDY; DRUG EFFICACY; ELECTROPORATION; GENE EXPRESSION; GENE SILENCING; GENETIC TRANSDUCTION; IMMUNOHISTOCHEMISTRY; IN VIVO GENE TRANSFER; KNOCKOUT GENE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING; WESTERN BLOTTING;

ANIMALS; CYCLOOXYGENASE 1; DERMATITIS, ATOPIC; DRUG DELIVERY SYSTEMS; ELECTROPORATION; GENE THERAPY; MICE; PRURITUS; RNA INTERFERENCE; RNA, SMALL INTERFERING; SKIN; TREATMENT OUTCOME;

MUS;

EID: 36148997263     PISSN: 1099498X     EISSN: 15212254     Source Type: Journal    
DOI: 10.1002/jgm.1091     Document Type: Article

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