Sustained release of vancomycin from polyurethane scaffolds inhibits infection of bone wounds in a rat femoral segmental defect model

Journal of Controlled Release

Volumn 145, Issue 3, 2010, Pages 221-230

  Li, Bing ^a,b   Brown, Kate V ^c   Wenke, Joseph C ^c   Guelcher, Scott A ^a,b  

^a VANDERBILT UNIVERSITY   (United States)

^b VANDERBILT UNIVERSITY   (United States)

^c US ARMY INSTITUTE OF SURGICAL RESEARCH   (United States)

Author keywords

Bone tissue engineering; Infection control; Polyurethane; Rat femoral segmental defect; Sustained release; Vancomycin

Indexed keywords

BONE DEFECT; BONE FORMATION; BONE GRAFT; BONE GRAFTING; BONE TISSUE ENGINEERING; CLINICAL THERAPY; CLINICAL USE; DEFECT MODEL; DELIVERY VEHICLE; FREE BASE; IN-VITRO; IN-VIVO; INFECTION CONTROL; MINIMUM INHIBITORY CONCENTRATION; POLYURETHANE SCAFFOLDS; RELEASE PROFILES; SUSTAINED RELEASE; TISSUE REGENERATION; VANCOMYCIN; VASCULARIZATION;

AMINO ACIDS; ANTIBIOTICS; BLOOD VESSELS; DEFECTS; ESTERS; FRACTURE; RAT CONTROL; SCAFFOLDS; TISSUE ENGINEERING;

BONE;

POLY(METHYL METHACRYLATE); POLYURETHAN; VANCOMYCIN; ANTIINFECTIVE AGENT; DELAYED RELEASE FORMULATION;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DEFECT; BONE GRAFT; BONE INFECTION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG SOLUBILITY; FEMUR; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; OPEN FRACTURE; OSSIFICATION; PRIORITY JOURNAL; RAT; SUSTAINED DRUG RELEASE; TISSUE REGENERATION; WOUND INFECTION; ANIMAL; CHEMISTRY; DELAYED RELEASE FORMULATION; SPRAGUE DAWLEY RAT;

ANIMALS; ANTI-BACTERIAL AGENTS; DELAYED-ACTION PREPARATIONS; FEMUR; POLYURETHANES; RATS; RATS, SPRAGUE-DAWLEY; VANCOMYCIN; WOUND INFECTION;

EID: 77954309514     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2010.04.002     Document Type: Article

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