An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection

Nature

Volumn 439, Issue 7072, 2006, Pages 89-94

  Palliser, Deborah ^a   Chowdhury, Dipanjan ^a   Wang, Qing Yin ^a   Lee, Sandra J ^a   Bronson, Roderick T ^a   Knipe, David M ^a   Lieberman, Judy ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DNA; FLAMMABILITY; GENES; LIPIDS; PLANTS (BOTANY); PROTEINS; RNA;

HERPES SIMPLEX VIRUS 2 INFECTION; LAMINA PROPRIA CELLS; SIRNA-BASED MICROBICIDE; SMALL INTERFERING RNAS (SIRNAS); VAGINAL INSTILLATION;

VIRUSES;

DNA BINDING PROTEIN; ENVELOPE PROTEIN; INTERFERON; LIPID; SMALL INTERFERING RNA; VIRUS GLYCOPROTEIN;

MEDICINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL STRAIN 3T3; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG TARGETING; DRUG TOLERABILITY; DRUG UPTAKE; EXPERIMENTAL INFECTION; FEMALE; GENE EXPRESSION REGULATION; GENE SILENCING; HERPES SIMPLEX; HERPES SIMPLEX VIRUS 2; INFLAMMATION; LAMINA PROPRIA; LETHALITY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTECTION; RNA INTERFERENCE; UTERINE CERVIX; VAGINA; VAGINA EPITHELIUM; VERO CELL; VIRUS ENVELOPE; VIRUS IMMUNITY;

ANIMALIA; HERPES; HUMAN HERPESVIRUS 2;

EID: 30144434185     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature04263     Document Type: Article

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