BSA degradation under acidic conditions: A model for protein instability during release from PLGA delivery systems

Journal of Pharmaceutical Sciences

Volumn 95, Issue 7, 2006, Pages 1626-1639

  Estey, Tia ^a   Kang, Jichao ^b   Schwendeman, Steven P ^c   Carpenter, John F ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b Neose Technologies Inc   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Acid denaturation; Bovine serum albumin; Circular dichroism; FTIR; Poly(lactide co glycolide) (PLGA); Protein aggregation; Protein stability; UV Vis spectroscopy

Indexed keywords

BOVINE SERUM ALBUMIN; POLYGLACTIN;

ACIDIFICATION; ARTICLE; CIRCULAR DICHROISM; DRUG DELIVERY SYSTEM; DRUG RELEASE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INFRARED SPECTROSCOPY; MICROCLIMATE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN HYDROLYSIS; PROTEIN STABILITY; SIMULATION; STRUCTURE ANALYSIS;

EID: 33745919229     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.20625     Document Type: Article

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