-
1
-
-
79959517565
-
Human fatty liver disease: Old questions and new insights
-
J.C. Cohen, J.D. Horton, and H.H. Hobbs Human fatty liver disease: old questions and new insights Science 332 2011 1519 1523
-
(2011)
Science
, vol.332
, pp. 1519-1523
-
-
Cohen, J.C.1
Horton, J.D.2
Hobbs, H.H.3
-
2
-
-
84880419922
-
Non-alcoholic steatohepatitis: Pathogenesis and novel therapeutic approaches
-
D. Schuppan, and J.M. Schattenberg Non-alcoholic steatohepatitis: pathogenesis and novel therapeutic approaches J Gastroenterol Hepatol 28 Suppl. 1 2013 68 76
-
(2013)
J Gastroenterol Hepatol
, vol.28
, pp. 68-76
-
-
Schuppan, D.1
Schattenberg, J.M.2
-
3
-
-
84887324215
-
Lipotoxicity in the liver
-
V. Zambo, L. Simon-Szabo, P. Szelenyi, E. Kereszturi, G. Banhegyi, and M. Csala Lipotoxicity in the liver World J Hepatol 5 2013 550 557
-
(2013)
World J Hepatol
, vol.5
, pp. 550-557
-
-
Zambo, V.1
Simon-Szabo, L.2
Szelenyi, P.3
Kereszturi, E.4
Banhegyi, G.5
Csala, M.6
-
4
-
-
84884810219
-
Hepatic manifestations of metabolic syndrome
-
[in press]
-
R. Medina-Santillan, J.A. Lopez-Velazquez, N. Chavez-Tapia, G. Torres-Villalobos, M. Uribe, and N. Mendez-Sanchez Hepatic manifestations of metabolic syndrome Diabetes Metab Res Rev 2013 10.1002/dmrr.2410 [in press]
-
(2013)
Diabetes Metab Res Rev
-
-
Medina-Santillan, R.1
Lopez-Velazquez, J.A.2
Chavez-Tapia, N.3
Torres-Villalobos, G.4
Uribe, M.5
Mendez-Sanchez, N.6
-
5
-
-
84885846436
-
G6PT-H6PDH-11betaHSD1 triad in the liver and its implication in the pathomechanism of the metabolic syndrome
-
I. Czegle, M. Csala, J. Mandl, A. Benedetti, I. Karadi, and G. Banhegyi G6PT-H6PDH-11betaHSD1 triad in the liver and its implication in the pathomechanism of the metabolic syndrome World J Hepatol 4 2012 129 138
-
(2012)
World J Hepatol
, vol.4
, pp. 129-138
-
-
Czegle, I.1
Csala, M.2
Mandl, J.3
Benedetti, A.4
Karadi, I.5
Banhegyi, G.6
-
6
-
-
84865975344
-
11beta-Hydroxysteroid dehydrogenase type 1: Relevance of its modulation in the pathophysiology of obesity, the metabolic syndrome and type 2 diabetes mellitus
-
C.D. Pereira, I. Azevedo, R. Monteiro, and M.J. Martins 11beta-Hydroxysteroid dehydrogenase type 1: relevance of its modulation in the pathophysiology of obesity, the metabolic syndrome and type 2 diabetes mellitus Diabetes Obes Metab 14 2012 869 881
-
(2012)
Diabetes Obes Metab
, vol.14
, pp. 869-881
-
-
Pereira, C.D.1
Azevedo, I.2
Monteiro, R.3
Martins, M.J.4
-
7
-
-
77951468032
-
Betaine improved adipose tissue function in mice fed a high-fat diet: A mechanism for hepatoprotective effect of betaine in nonalcoholic fatty liver disease
-
Z. Wang, T. Yao, M. Pini, Z. Zhou, G. Fantuzzi, and Z. Song Betaine improved adipose tissue function in mice fed a high-fat diet: a mechanism for hepatoprotective effect of betaine in nonalcoholic fatty liver disease Am J Physiol Gastrointest Liver Physiol 298 2010 G634 G642
-
(2010)
Am J Physiol Gastrointest Liver Physiol
, vol.298
, pp. G634-G642
-
-
Wang, Z.1
Yao, T.2
Pini, M.3
Zhou, Z.4
Fantuzzi, G.5
Song, Z.6
-
8
-
-
84899447215
-
Obesity-associated mechanisms of hepatocarcinogenesis
-
R. Karagozian, Z. Derdak, and G. Baffy Obesity-associated mechanisms of hepatocarcinogenesis Metabolism 63 2014 607 617
-
(2014)
Metabolism
, vol.63
, pp. 607-617
-
-
Karagozian, R.1
Derdak, Z.2
Baffy, G.3
-
9
-
-
84904288578
-
ER calcium release promotes mitochondrial dysfunction and hepatic cell lipotoxicity in response to palmitate overload
-
R.A. Egnatchik, A.K. Leamy, D.A. Jacobson, M. Shiota, and J.D. Young ER calcium release promotes mitochondrial dysfunction and hepatic cell lipotoxicity in response to palmitate overload Mol Metab 3 2014 544 553
-
(2014)
Mol Metab
, vol.3
, pp. 544-553
-
-
Egnatchik, R.A.1
Leamy, A.K.2
Jacobson, D.A.3
Shiota, M.4
Young, J.D.5
-
10
-
-
84876677845
-
Fatty acid-mediated endoplasmic reticulum stress in vivo: Differential response to the infusion of soybean and lard oil in rats
-
A.M. Nivala, L. Reese, M. Frye, C.L. Gentile, and M.J. Pagliassotti Fatty acid-mediated endoplasmic reticulum stress in vivo: differential response to the infusion of soybean and lard oil in rats Metabolism 62 2013 753 760
-
(2013)
Metabolism
, vol.62
, pp. 753-760
-
-
Nivala, A.M.1
Reese, L.2
Frye, M.3
Gentile, C.L.4
Pagliassotti, M.J.5
-
11
-
-
84902551389
-
De novo lipogenesis in health and disease
-
F. Ameer, L. Scandiuzzi, S. Hasnain, H. Kalbacher, and N. Zaidi De novo lipogenesis in health and disease Metabolism 63 2014 895 902
-
(2014)
Metabolism
, vol.63
, pp. 895-902
-
-
Ameer, F.1
Scandiuzzi, L.2
Hasnain, S.3
Kalbacher, H.4
Zaidi, N.5
-
12
-
-
66349088529
-
Hepatic triacylglycerol accumulation and insulin resistance
-
[Suppl.]
-
C.A. Nagle, E.L. Klett, and R.A. Coleman Hepatic triacylglycerol accumulation and insulin resistance J Lipid Res 50 2009 S74 S79 [Suppl.]
-
(2009)
J Lipid Res
, vol.50
, pp. S74-S79
-
-
Nagle, C.A.1
Klett, E.L.2
Coleman, R.A.3
-
13
-
-
84908665169
-
ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development
-
H. Nakagawa, A. Umemura, K. Taniguchi, J. Font-Burgada, D. Dhar, and H. Ogata ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development Cancer Cell 26 2014 331 343
-
(2014)
Cancer Cell
, vol.26
, pp. 331-343
-
-
Nakagawa, H.1
Umemura, A.2
Taniguchi, K.3
Font-Burgada, J.4
Dhar, D.5
Ogata, H.6
-
14
-
-
58249085901
-
High fat diet induces dysregulation of hepatic oxygen gradients and mitochondrial function in vivo
-
S.K. Mantena, D.P. Vaughn, K.K. Andringa, H.B. Eccleston, A.L. King, and G.A. Abrams High fat diet induces dysregulation of hepatic oxygen gradients and mitochondrial function in vivo Biochem J 417 2009 183 193
-
(2009)
Biochem J
, vol.417
, pp. 183-193
-
-
Mantena, S.K.1
Vaughn, D.P.2
Andringa, K.K.3
Eccleston, H.B.4
King, A.L.5
Abrams, G.A.6
-
15
-
-
42949178968
-
Alterations in hepatic mitochondrial compartment in a model of obesity and insulin resistance
-
C. Raffaella, B. Francesca, F. Italia, P. Marina, L. Giovanna, and I. Susanna Alterations in hepatic mitochondrial compartment in a model of obesity and insulin resistance Obesity (Silver Spring) 16 2008 958 964
-
(2008)
Obesity (Silver Spring)
, vol.16
, pp. 958-964
-
-
Raffaella, C.1
Francesca, B.2
Italia, F.3
Marina, P.4
Giovanna, L.5
Susanna, I.6
-
16
-
-
0035084699
-
Nonalcoholic steatohepatitis: Association of insulin resistance and mitochondrial abnormalities
-
A.J. Sanyal, C. Campbell-Sargent, F. Mirshahi, W.B. Rizzo, M.J. Contos, and R.K. Sterling Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities Gastroenterology 120 2001 1183 1192
-
(2001)
Gastroenterology
, vol.120
, pp. 1183-1192
-
-
Sanyal, A.J.1
Campbell-Sargent, C.2
Mirshahi, F.3
Rizzo, W.B.4
Contos, M.J.5
Sterling, R.K.6
-
17
-
-
66449137379
-
GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice
-
H.L. Kammoun, H. Chabanon, I. Hainault, S. Luquet, C. Magnan, and T. Koike GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice J Clin Invest 119 2009 1201 1215
-
(2009)
J Clin Invest
, vol.119
, pp. 1201-1215
-
-
Kammoun, H.L.1
Chabanon, H.2
Hainault, I.3
Luquet, S.4
Magnan, C.5
Koike, T.6
-
18
-
-
79957605136
-
Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity
-
S. Fu, L. Yang, P. Li, O. Hofmann, L. Dicker, and W. Hide Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity Nature 473 2011 528 531
-
(2011)
Nature
, vol.473
, pp. 528-531
-
-
Fu, S.1
Yang, L.2
Li, P.3
Hofmann, O.4
Dicker, L.5
Hide, W.6
-
19
-
-
79952708723
-
Endoplasmic reticulum stress in liver disease
-
H. Malhi, and R.J. Kaufman Endoplasmic reticulum stress in liver disease J Hepatol 54 2011 795 809
-
(2011)
J Hepatol
, vol.54
, pp. 795-809
-
-
Malhi, H.1
Kaufman, R.J.2
-
20
-
-
5644231992
-
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
-
U. Ozcan, Q. Cao, E. Yilmaz, A.H. Lee, N.N. Iwakoshi, and E. Ozdelen Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes Science 306 2004 457 461
-
(2004)
Science
, vol.306
, pp. 457-461
-
-
Ozcan, U.1
Cao, Q.2
Yilmaz, E.3
Lee, A.H.4
Iwakoshi, N.N.5
Ozdelen, E.6
-
21
-
-
84892646801
-
Unfolded protein response signaling and metabolic diseases
-
J. Lee, and U. Ozcan Unfolded protein response signaling and metabolic diseases J Biol Chem 289 2014 1203 1211
-
(2014)
J Biol Chem
, vol.289
, pp. 1203-1211
-
-
Lee, J.1
Ozcan, U.2
-
22
-
-
84894234845
-
Role of endoplasmic reticulum stress in the pathogenesis of nonalcoholic fatty liver disease
-
X.Q. Zhang, C.F. Xu, C.H. Yu, W.X. Chen, and Y.M. Li Role of endoplasmic reticulum stress in the pathogenesis of nonalcoholic fatty liver disease World J Gastroenterol 20 2014 1768 1776
-
(2014)
World J Gastroenterol
, vol.20
, pp. 1768-1776
-
-
Zhang, X.Q.1
Xu, C.F.2
Yu, C.H.3
Chen, W.X.4
Li, Y.M.5
-
23
-
-
84858987289
-
Pharmacologic ER stress induces non-alcoholic steatohepatitis in an animal model
-
J.S. Lee, Z. Zheng, R. Mendez, S.W. Ha, Y. Xie, and K. Zhang Pharmacologic ER stress induces non-alcoholic steatohepatitis in an animal model Toxicol Lett 211 2012 29 38
-
(2012)
Toxicol Lett
, vol.211
, pp. 29-38
-
-
Lee, J.S.1
Zheng, Z.2
Mendez, R.3
Ha, S.W.4
Xie, Y.5
Zhang, K.6
-
24
-
-
77950343252
-
Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
-
G.S. Hotamisligil Endoplasmic reticulum stress and the inflammatory basis of metabolic disease Cell 140 2010 900 917
-
(2010)
Cell
, vol.140
, pp. 900-917
-
-
Hotamisligil, G.S.1
-
25
-
-
47949099916
-
From endoplasmic-reticulum stress to the inflammatory response
-
K. Zhang, and R.J. Kaufman From endoplasmic-reticulum stress to the inflammatory response Nature 454 2008 455 462
-
(2008)
Nature
, vol.454
, pp. 455-462
-
-
Zhang, K.1
Kaufman, R.J.2
-
26
-
-
34250899722
-
Signal integration in the endoplasmic reticulum unfolded protein response
-
D. Ron, and P. Walter Signal integration in the endoplasmic reticulum unfolded protein response Nat Rev Mol Cell Biol 8 2007 519 529
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 519-529
-
-
Ron, D.1
Walter, P.2
-
27
-
-
54949110895
-
Calcium and apoptosis: ER-mitochondria Ca2 + transfer in the control of apoptosis
-
P. Pinton, C. Giorgi, R. Siviero, E. Zecchini, and R. Rizzuto Calcium and apoptosis: ER-mitochondria Ca2 + transfer in the control of apoptosis Oncogene 27 2008 6407 6418
-
(2008)
Oncogene
, vol.27
, pp. 6407-6418
-
-
Pinton, P.1
Giorgi, C.2
Siviero, R.3
Zecchini, E.4
Rizzuto, R.5
-
29
-
-
84885421216
-
Exercise as a therapeutic tool to prevent mitochondrial degeneration in nonalcoholic steatohepatitis
-
I.O. Goncalves, P.J. Oliveira, A. Ascensao, and J. Magalhaes Exercise as a therapeutic tool to prevent mitochondrial degeneration in nonalcoholic steatohepatitis Eur J Clin Invest 43 2013 1184 1194
-
(2013)
Eur J Clin Invest
, vol.43
, pp. 1184-1194
-
-
Goncalves, I.O.1
Oliveira, P.J.2
Ascensao, A.3
Magalhaes, J.4
-
30
-
-
53149132796
-
Voluntary exercise improves insulin sensitivity and adipose tissue inflammation in diet-induced obese mice
-
R.L. Bradley, J.Y. Jeon, F.F. Liu, and E. Maratos-Flier Voluntary exercise improves insulin sensitivity and adipose tissue inflammation in diet-induced obese mice Am J Physiol Endocrinol Metab 295 2008 E586 E594
-
(2008)
Am J Physiol Endocrinol Metab
, vol.295
, pp. E586-E594
-
-
Bradley, R.L.1
Jeon, J.Y.2
Liu, F.F.3
Maratos-Flier, E.4
-
31
-
-
77953606318
-
Exercise training increases hepatic endoplasmic reticulum (er) stress protein expression in MTP-inhibited high-fat fed rats
-
N.A. Chapados, and J.M. Lavoie Exercise training increases hepatic endoplasmic reticulum (er) stress protein expression in MTP-inhibited high-fat fed rats Cell Biochem Funct 28 2010 202 210
-
(2010)
Cell Biochem Funct
, vol.28
, pp. 202-210
-
-
Chapados, N.A.1
Lavoie, J.M.2
-
32
-
-
80053902834
-
Endurance exercise training ameliorates insulin resistance and reticulum stress in adipose and hepatic tissue in obese rats
-
G. da Luz, M.J. Frederico, S. da Silva, M.F. Vitto, P.A. Cesconetto, and R.A. de Pinho Endurance exercise training ameliorates insulin resistance and reticulum stress in adipose and hepatic tissue in obese rats Eur J Appl Physiol 111 2011 2015 2023
-
(2011)
Eur J Appl Physiol
, vol.111
, pp. 2015-2023
-
-
Da Luz, G.1
Frederico, M.J.2
Da Silva, S.3
Vitto, M.F.4
Cesconetto, P.A.5
De Pinho, R.A.6
-
33
-
-
84855326549
-
Voluntary running exercise prevents beta-cell failure in susceptible islets of the Zucker diabetic fatty rat
-
V. Delghingaro-Augusto, S. Decary, M.L. Peyot, M.G. Latour, J. Lamontagne, and N. Paradis-Isler Voluntary running exercise prevents beta-cell failure in susceptible islets of the Zucker diabetic fatty rat Am J Physiol Endocrinol Metab 302 2012 E254 E264
-
(2012)
Am J Physiol Endocrinol Metab
, vol.302
, pp. E254-E264
-
-
Delghingaro-Augusto, V.1
Decary, S.2
Peyot, M.L.3
Latour, M.G.4
Lamontagne, J.5
Paradis-Isler, N.6
-
34
-
-
80053295242
-
Voluntary exercise attenuates obesity-associated inflammation through ghrelin expressed in macrophages
-
T. Kizaki, T. Maegawa, T. Sakurai, J.E. Ogasawara, T. Ookawara, and S. Oh-ishi Voluntary exercise attenuates obesity-associated inflammation through ghrelin expressed in macrophages Biochem Biophys Res Commun 413 2011 454 459
-
(2011)
Biochem Biophys Res Commun
, vol.413
, pp. 454-459
-
-
Kizaki, T.1
Maegawa, T.2
Sakurai, T.3
Ogasawara, J.E.4
Ookawara, T.5
Oh-Ishi, S.6
-
35
-
-
79952389476
-
Physical exercise reduces circulating lipopolysaccharide and TLR4 activation and improves insulin signaling in tissues of DIO rats
-
A.G. Oliveira, B.M. Carvalho, N. Tobar, E.R. Ropelle, J.R. Pauli, and R.A. Bagarolli Physical exercise reduces circulating lipopolysaccharide and TLR4 activation and improves insulin signaling in tissues of DIO rats Diabetes 60 2011 784 796
-
(2011)
Diabetes
, vol.60
, pp. 784-796
-
-
Oliveira, A.G.1
Carvalho, B.M.2
Tobar, N.3
Ropelle, E.R.4
Pauli, J.R.5
Bagarolli, R.A.6
-
36
-
-
84899681057
-
Physical exercise prevents and mitigates non-alcoholic steatohepatitis-induced liver mitochondrial structural and bioenergetics impairments
-
I.O. Goncalves, E. Passos, S. Rocha-Rodrigues, C.V. Diogo, J.R. Torrella, and D. Rizo Physical exercise prevents and mitigates non-alcoholic steatohepatitis-induced liver mitochondrial structural and bioenergetics impairments Mitochondrion 15 2014 40 51
-
(2014)
Mitochondrion
, vol.15
, pp. 40-51
-
-
Goncalves, I.O.1
Passos, E.2
Rocha-Rodrigues, S.3
Diogo, C.V.4
Torrella, J.R.5
Rizo, D.6
-
37
-
-
84887018523
-
Modulation of hepatic redox status and mitochondrial metabolism by exercise: Therapeutic strategy for liver diseases
-
A. Ascensao, M.J. Martins, E. Santos-Alves, I.O. Goncalves, P. Portincasa, and P.J. Oliveira Modulation of hepatic redox status and mitochondrial metabolism by exercise: therapeutic strategy for liver diseases Mitochondrion 13 2013 862 870
-
(2013)
Mitochondrion
, vol.13
, pp. 862-870
-
-
Ascensao, A.1
Martins, M.J.2
Santos-Alves, E.3
Goncalves, I.O.4
Portincasa, P.5
Oliveira, P.J.6
-
38
-
-
84921665807
-
Role of physical exercise on hepatic insulin, glucocorticoid and inflammatory signaling pathways in an animal model of non-alcoholic steatohepatitis
-
E. Passos, C. Pereira, I.O. Goncalves, S. Rocha-Rodrigues, N. Silva, and J.T. Guimaraes Role of physical exercise on hepatic insulin, glucocorticoid and inflammatory signaling pathways in an animal model of non-alcoholic steatohepatitis Life Sci 123 2015 51 60
-
(2015)
Life Sci
, vol.123
, pp. 51-60
-
-
Passos, E.1
Pereira, C.2
Goncalves, I.O.3
Rocha-Rodrigues, S.4
Silva, N.5
Guimaraes, J.T.6
-
39
-
-
35848957485
-
Endoplasmic reticulum stress and oxidative stress: A vicious cycle or a double-edged sword?
-
J.D. Malhotra, and R.J. Kaufman Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword? Antioxid Redox Signal 9 2007 2277 2293
-
(2007)
Antioxid Redox Signal
, vol.9
, pp. 2277-2293
-
-
Malhotra, J.D.1
Kaufman, R.J.2
-
40
-
-
84856111924
-
The unfolded protein response: Controlling cell fate decisions under ER stress and beyond
-
C. Hetz The unfolded protein response: controlling cell fate decisions under ER stress and beyond Nat Rev Mol Cell Biol 13 2012 89 102
-
(2012)
Nat Rev Mol Cell Biol
, vol.13
, pp. 89-102
-
-
Hetz, C.1
-
41
-
-
29244462498
-
Coordination of ER and oxidative stress signaling: The PERK/Nrf2 signaling pathway
-
S.B. Cullinan, and J.A. Diehl Coordination of ER and oxidative stress signaling: the PERK/Nrf2 signaling pathway Int J Biochem Cell Biol 38 2006 317 332
-
(2006)
Int J Biochem Cell Biol
, vol.38
, pp. 317-332
-
-
Cullinan, S.B.1
Diehl, J.A.2
-
42
-
-
0141752795
-
Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival
-
S.B. Cullinan, D. Zhang, M. Hannink, E. Arvisais, R.J. Kaufman, and J.A. Diehl Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival Mol Cell Biol 23 2003 7198 7209
-
(2003)
Mol Cell Biol
, vol.23
, pp. 7198-7209
-
-
Cullinan, S.B.1
Zhang, D.2
Hannink, M.3
Arvisais, E.4
Kaufman, R.J.5
Diehl, J.A.6
-
43
-
-
84860483727
-
The role of endoplasmic reticulum in hepatic lipid homeostasis and stress signaling
-
S. Fu, S.M. Watkins, and G.S. Hotamisligil The role of endoplasmic reticulum in hepatic lipid homeostasis and stress signaling Cell Metab 15 2012 623 634
-
(2012)
Cell Metab
, vol.15
, pp. 623-634
-
-
Fu, S.1
Watkins, S.M.2
Hotamisligil, G.S.3
-
44
-
-
84857861919
-
Mechanisms for insulin resistance: Common threads and missing links
-
V.T. Samuel, and G.I. Shulman Mechanisms for insulin resistance: common threads and missing links Cell 148 2012 852 871
-
(2012)
Cell
, vol.148
, pp. 852-871
-
-
Samuel, V.T.1
Shulman, G.I.2
-
45
-
-
84921513148
-
Endoplasmic reticulum stress in adipose tissue augments lipolysis
-
E. Bogdanovic, N. Kraus, D. Patsouris, L. Diao, V. Wang, and A. Abdullahi Endoplasmic reticulum stress in adipose tissue augments lipolysis J Cell Mol Med 19 2015 82 91
-
(2015)
J Cell Mol Med
, vol.19
, pp. 82-91
-
-
Bogdanovic, E.1
Kraus, N.2
Patsouris, D.3
Diao, L.4
Wang, V.5
Abdullahi, A.6
-
46
-
-
84893405239
-
Enhanced endoplasmic reticulum SERCA activity by overexpression of hepatic stimulator substance gene prevents hepatic cells from ER stress-induced apoptosis
-
J. Zhang, Y. Li, S. Jiang, H. Yu, and W. An Enhanced endoplasmic reticulum SERCA activity by overexpression of hepatic stimulator substance gene prevents hepatic cells from ER stress-induced apoptosis Am J Physiol Cell Physiol 306 2014 C279 C290
-
(2014)
Am J Physiol Cell Physiol
, vol.306
, pp. C279-C290
-
-
Zhang, J.1
Li, Y.2
Jiang, S.3
Yu, H.4
An, W.5
-
47
-
-
45849137877
-
Regulation of hepatic lipogenesis by the transcription factor XBP1
-
A.H. Lee, E.F. Scapa, D.E. Cohen, and L.H. Glimcher Regulation of hepatic lipogenesis by the transcription factor XBP1 Science 320 2008 1492 1496
-
(2008)
Science
, vol.320
, pp. 1492-1496
-
-
Lee, A.H.1
Scapa, E.F.2
Cohen, D.E.3
Glimcher, L.H.4
-
48
-
-
30944451788
-
Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis
-
D. Wang, Y. Wei, and M.J. Pagliassotti Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis Endocrinology 147 2006 943 951
-
(2006)
Endocrinology
, vol.147
, pp. 943-951
-
-
Wang, D.1
Wei, Y.2
Pagliassotti, M.J.3
-
49
-
-
84895749916
-
Multiple pathways are involved in palmitic acid-induced toxicity
-
E.J. Park, A.Y. Lee, S. Park, J.H. Kim, and M.H. Cho Multiple pathways are involved in palmitic acid-induced toxicity Food Chem Toxicol 67 2014 26 34
-
(2014)
Food Chem Toxicol
, vol.67
, pp. 26-34
-
-
Park, E.J.1
Lee, A.Y.2
Park, S.3
Kim, J.H.4
Cho, M.H.5
-
50
-
-
32044453080
-
Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response
-
K. Zhang, X. Shen, J. Wu, K. Sakaki, T. Saunders, and D.T. Rutkowski Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response Cell 124 2006 587 599
-
(2006)
Cell
, vol.124
, pp. 587-599
-
-
Zhang, K.1
Shen, X.2
Wu, J.3
Sakaki, K.4
Saunders, T.5
Rutkowski, D.T.6
-
51
-
-
84904015435
-
Enhanced synthesis of saturated phospholipids is associated with ER stress and lipotoxicity in palmitate treated hepatic cells
-
A.K. Leamy, R.A. Egnatchik, M. Shiota, P.T. Ivanova, D.S. Myers, and H.A. Brown Enhanced synthesis of saturated phospholipids is associated with ER stress and lipotoxicity in palmitate treated hepatic cells J Lipid Res 55 2014 1478 1488
-
(2014)
J Lipid Res
, vol.55
, pp. 1478-1488
-
-
Leamy, A.K.1
Egnatchik, R.A.2
Shiota, M.3
Ivanova, P.T.4
Myers, D.S.5
Brown, H.A.6
-
52
-
-
78650615554
-
Sarco(endo)plasmic reticulum Ca2+-ATPase 2b is a major regulator of endoplasmic reticulum stress and glucose homeostasis in obesity
-
S.W. Park, Y. Zhou, J. Lee, and U. Ozcan Sarco(endo)plasmic reticulum Ca2+-ATPase 2b is a major regulator of endoplasmic reticulum stress and glucose homeostasis in obesity Proc Natl Acad Sci U S A 107 2010 19320 19325
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 19320-19325
-
-
Park, S.W.1
Zhou, Y.2
Lee, J.3
Ozcan, U.4
-
53
-
-
78650894319
-
Crosstalk of reactive oxygen species and NF-kappaB signaling
-
M.J. Morgan, and Z.G. Liu Crosstalk of reactive oxygen species and NF-kappaB signaling Cell Res 21 2011 103 115
-
(2011)
Cell Res
, vol.21
, pp. 103-115
-
-
Morgan, M.J.1
Liu, Z.G.2
-
54
-
-
33645815074
-
Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression
-
P. Hu, Z. Han, A.D. Couvillon, R.J. Kaufman, and J.H. Exton Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression Mol Cell Biol 26 2006 3071 3084
-
(2006)
Mol Cell Biol
, vol.26
, pp. 3071-3084
-
-
Hu, P.1
Han, Z.2
Couvillon, A.D.3
Kaufman, R.J.4
Exton, J.H.5
-
55
-
-
0034723235
-
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
-
F. Urano, X. Wang, A. Bertolotti, Y. Zhang, P. Chung, and H.P. Harding Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1 Science 287 2000 664 666
-
(2000)
Science
, vol.287
, pp. 664-666
-
-
Urano, F.1
Wang, X.2
Bertolotti, A.3
Zhang, Y.4
Chung, P.5
Harding, H.P.6
-
56
-
-
77955806634
-
JNK1 and IKKbeta: Molecular links between obesity and metabolic dysfunction
-
G. Solinas, and M. Karin JNK1 and IKKbeta: molecular links between obesity and metabolic dysfunction FASEB J 24 2010 2596 2611
-
(2010)
FASEB J
, vol.24
, pp. 2596-2611
-
-
Solinas, G.1
Karin, M.2
-
57
-
-
8644282751
-
Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2
-
J. Deng, P.D. Lu, Y. Zhang, D. Scheuner, R.J. Kaufman, and N. Sonenberg Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2 Mol Cell Biol 24 2004 10161 10168
-
(2004)
Mol Cell Biol
, vol.24
, pp. 10161-10168
-
-
Deng, J.1
Lu, P.D.2
Zhang, Y.3
Scheuner, D.4
Kaufman, R.J.5
Sonenberg, N.6
-
58
-
-
20044387026
-
IKK-beta links inflammation to obesity-induced insulin resistance
-
M.C. Arkan, A.L. Hevener, F.R. Greten, S. Maeda, Z.W. Li, and J.M. Long IKK-beta links inflammation to obesity-induced insulin resistance Nat Med 11 2005 191 198
-
(2005)
Nat Med
, vol.11
, pp. 191-198
-
-
Arkan, M.C.1
Hevener, A.L.2
Greten, F.R.3
Maeda, S.4
Li, Z.W.5
Long, J.M.6
-
59
-
-
14644427890
-
Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB
-
D. Cai, M. Yuan, D.F. Frantz, P.A. Melendez, L. Hansen, and J. Lee Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB Nat Med 11 2005 183 190
-
(2005)
Nat Med
, vol.11
, pp. 183-190
-
-
Cai, D.1
Yuan, M.2
Frantz, D.F.3
Melendez, P.A.4
Hansen, L.5
Lee, J.6
-
60
-
-
0034708832
-
The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)
-
V. Aguirre, T. Uchida, L. Yenush, R. Davis, and M.F. White The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307) J Biol Chem 275 2000 9047 9054
-
(2000)
J Biol Chem
, vol.275
, pp. 9047-9054
-
-
Aguirre, V.1
Uchida, T.2
Yenush, L.3
Davis, R.4
White, M.F.5
-
61
-
-
69249213467
-
Hepatic insulin resistance, metabolic syndrome and cardiovascular disease
-
R. Meshkani, and K. Adeli Hepatic insulin resistance, metabolic syndrome and cardiovascular disease Clin Biochem 42 2009 1331 1346
-
(2009)
Clin Biochem
, vol.42
, pp. 1331-1346
-
-
Meshkani, R.1
Adeli, K.2
-
62
-
-
33749076455
-
Mechanisms of crosstalk between TNF-induced NF-kappaB and JNK activation in hepatocytes
-
A. Wullaert, K. Heyninck, and R. Beyaert Mechanisms of crosstalk between TNF-induced NF-kappaB and JNK activation in hepatocytes Biochem Pharmacol 72 2006 1090 1101
-
(2006)
Biochem Pharmacol
, vol.72
, pp. 1090-1101
-
-
Wullaert, A.1
Heyninck, K.2
Beyaert, R.3
-
63
-
-
58149337392
-
Cytokine-induced beta-cell death is independent of endoplasmic reticulum stress signaling
-
M.C. Akerfeldt, J. Howes, J.Y. Chan, V.A. Stevens, N. Boubenna, and H.M. McGuire Cytokine-induced beta-cell death is independent of endoplasmic reticulum stress signaling Diabetes 57 2008 3034 3044
-
(2008)
Diabetes
, vol.57
, pp. 3034-3044
-
-
Akerfeldt, M.C.1
Howes, J.2
Chan, J.Y.3
Stevens, V.A.4
Boubenna, N.5
McGuire, H.M.6
-
64
-
-
19944432792
-
Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2 + ATPase 2b and deplete endoplasmic reticulum Ca2 +, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells
-
A.K. Cardozo, F. Ortis, J. Storling, Y.M. Feng, J. Rasschaert, and M. Tonnesen Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2 + ATPase 2b and deplete endoplasmic reticulum Ca2 +, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells Diabetes 54 2005 452 461
-
(2005)
Diabetes
, vol.54
, pp. 452-461
-
-
Cardozo, A.K.1
Ortis, F.2
Storling, J.3
Feng, Y.M.4
Rasschaert, J.5
Tonnesen, M.6
-
65
-
-
84862742723
-
Mild endoplasmic reticulum stress augments the proinflammatory effect of IL-1beta in pancreatic rat beta-cells via the IRE1alpha/XBP1s pathway
-
M. Miani, M.L. Colli, L. Ladriere, M. Cnop, and D.L. Eizirik Mild endoplasmic reticulum stress augments the proinflammatory effect of IL-1beta in pancreatic rat beta-cells via the IRE1alpha/XBP1s pathway Endocrinology 153 2012 3017 3028
-
(2012)
Endocrinology
, vol.153
, pp. 3017-3028
-
-
Miani, M.1
Colli, M.L.2
Ladriere, L.3
Cnop, M.4
Eizirik, D.L.5
-
66
-
-
84908692718
-
Endoplasmic reticulum stress: At the crossroads of inflammation and metabolism in hepatocellular carcinoma development
-
M. Maurel, A. Samali, and E. Chevet Endoplasmic reticulum stress: at the crossroads of inflammation and metabolism in hepatocellular carcinoma development Cancer Cell 26 2014 301 303
-
(2014)
Cancer Cell
, vol.26
, pp. 301-303
-
-
Maurel, M.1
Samali, A.2
Chevet, E.3
-
67
-
-
0031127305
-
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha
-
D.R. Alessi, S.R. James, C.P. Downes, A.B. Holmes, P.R. Gaffney, and C.B. Reese Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha Curr Biol 7 1997 261 269
-
(1997)
Curr Biol
, vol.7
, pp. 261-269
-
-
Alessi, D.R.1
James, S.R.2
Downes, C.P.3
Holmes, A.B.4
Gaffney, P.R.5
Reese, C.B.6
-
68
-
-
65649098029
-
Phosphorylation of IRS proteins, insulin action, and insulin resistance
-
S. Boura-Halfon, and Y. Zick Phosphorylation of IRS proteins, insulin action, and insulin resistance Am J Physiol Endocrinol Metab 296 2009 E581 E591
-
(2009)
Am J Physiol Endocrinol Metab
, vol.296
, pp. E581-E591
-
-
Boura-Halfon, S.1
Zick, Y.2
-
69
-
-
38949119009
-
Sequential phosphorylation of insulin receptor substrate-2 by glycogen synthase kinase-3 and c-Jun NH2-terminal kinase plays a role in hepatic insulin signaling
-
H. Sharfi, and H. Eldar-Finkelman Sequential phosphorylation of insulin receptor substrate-2 by glycogen synthase kinase-3 and c-Jun NH2-terminal kinase plays a role in hepatic insulin signaling Am J Physiol Endocrinol Metab 294 2008 E307 E315
-
(2008)
Am J Physiol Endocrinol Metab
, vol.294
, pp. E307-E315
-
-
Sharfi, H.1
Eldar-Finkelman, H.2
-
70
-
-
70449724835
-
Cellular mechanisms of insulin resistance: Role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation
-
J.F. Tanti, and J. Jager Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation Curr Opin Pharmacol 9 2009 753 762
-
(2009)
Curr Opin Pharmacol
, vol.9
, pp. 753-762
-
-
Tanti, J.F.1
Jager, J.2
-
71
-
-
0037153158
-
A central role for JNK in obesity and insulin resistance
-
J. Hirosumi, G. Tuncman, L. Chang, C.Z. Gorgun, K.T. Uysal, and K. Maeda A central role for JNK in obesity and insulin resistance Nature 420 2002 333 336
-
(2002)
Nature
, vol.420
, pp. 333-336
-
-
Hirosumi, J.1
Tuncman, G.2
Chang, L.3
Gorgun, C.Z.4
Uysal, K.T.5
Maeda, K.6
-
72
-
-
34547942526
-
Liver-specific knockdown of JNK1 up-regulates proliferator-activated receptor gamma coactivator 1 beta and increases plasma triglyceride despite reduced glucose and insulin levels in diet-induced obese mice
-
R. Yang, D.M. Wilcox, D.L. Haasch, P.M. Jung, P.T. Nguyen, and M.J. Voorbach Liver-specific knockdown of JNK1 up-regulates proliferator-activated receptor gamma coactivator 1 beta and increases plasma triglyceride despite reduced glucose and insulin levels in diet-induced obese mice J Biol Chem 282 2007 22765 22774
-
(2007)
J Biol Chem
, vol.282
, pp. 22765-22774
-
-
Yang, R.1
Wilcox, D.M.2
Haasch, D.L.3
Jung, P.M.4
Nguyen, P.T.5
Voorbach, M.J.6
-
73
-
-
79952698689
-
Inflammatory signals shift from adipose to liver during high fat feeding and influence the development of steatohepatitis in mice
-
M.C. Stanton, S.C. Chen, J.V. Jackson, A. Rojas-Triana, D. Kinsley, and L. Cui Inflammatory signals shift from adipose to liver during high fat feeding and influence the development of steatohepatitis in mice J Inflamm 8 2011 8
-
(2011)
J Inflamm
, vol.8
, pp. 8
-
-
Stanton, M.C.1
Chen, S.C.2
Jackson, J.V.3
Rojas-Triana, A.4
Kinsley, D.5
Cui, L.6
-
74
-
-
84862577245
-
Deletion of C/EBP homologous protein (Chop) in C57Bl/6 mice dissociates obesity from insulin resistance
-
M. Maris, L. Overbergh, C. Gysemans, A. Waget, A.K. Cardozo, and E. Verdrengh Deletion of C/EBP homologous protein (Chop) in C57Bl/6 mice dissociates obesity from insulin resistance Diabetologia 55 2012 1167 1178
-
(2012)
Diabetologia
, vol.55
, pp. 1167-1178
-
-
Maris, M.1
Overbergh, L.2
Gysemans, C.3
Waget, A.4
Cardozo, A.K.5
Verdrengh, E.6
-
75
-
-
48249089367
-
Protein kinase C function in muscle, liver, and beta-cells and its therapeutic implications for type 2 diabetes
-
C. Schmitz-Peiffer, and T.J. Biden Protein kinase C function in muscle, liver, and beta-cells and its therapeutic implications for type 2 diabetes Diabetes 57 2008 1774 1783
-
(2008)
Diabetes
, vol.57
, pp. 1774-1783
-
-
Schmitz-Peiffer, C.1
Biden, T.J.2
-
76
-
-
0033525870
-
Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene
-
M. Elchebly, P. Payette, E. Michaliszyn, W. Cromlish, S. Collins, and A.L. Loy Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene Science 283 1999 1544 1548
-
(1999)
Science
, vol.283
, pp. 1544-1548
-
-
Elchebly, M.1
Payette, P.2
Michaliszyn, E.3
Cromlish, W.4
Collins, S.5
Loy, A.L.6
-
77
-
-
0034635374
-
Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein
-
B.J. Goldstein, A. Bittner-Kowalczyk, M.F. White, and M. Harbeck Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein J Biol Chem 275 2000 4283 4289
-
(2000)
J Biol Chem
, vol.275
, pp. 4283-4289
-
-
Goldstein, B.J.1
Bittner-Kowalczyk, A.2
White, M.F.3
Harbeck, M.4
-
78
-
-
0033942614
-
Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice
-
L.D. Klaman, O. Boss, O.D. Peroni, J.K. Kim, J.L. Martino, and J.M. Zabolotny Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice Mol Cell Biol 20 2000 5479 5489
-
(2000)
Mol Cell Biol
, vol.20
, pp. 5479-5489
-
-
Klaman, L.D.1
Boss, O.2
Peroni, O.D.3
Kim, J.K.4
Martino, J.L.5
Zabolotny, J.M.6
-
79
-
-
84885743311
-
Protein tyrosine phosphatase 1B and insulin resistance: Role of endoplasmic reticulum stress/reactive oxygen species/nuclear factor kappa B axis
-
E. Panzhinskiy, J. Ren, and S. Nair Protein tyrosine phosphatase 1B and insulin resistance: role of endoplasmic reticulum stress/reactive oxygen species/nuclear factor kappa B axis PLoS One 8 2013 e77228
-
(2013)
PLoS One
, vol.8
, pp. e77228
-
-
Panzhinskiy, E.1
Ren, J.2
Nair, S.3
-
80
-
-
84861567265
-
Redox signaling loops in the unfolded protein response
-
A. Higa, and E. Chevet Redox signaling loops in the unfolded protein response Cell Signal 24 2012 1548 1555
-
(2012)
Cell Signal
, vol.24
, pp. 1548-1555
-
-
Higa, A.1
Chevet, E.2
-
81
-
-
0142150051
-
Mitochondrial formation of reactive oxygen species
-
J.F. Turrens Mitochondrial formation of reactive oxygen species J Physiol 552 2003 335 344
-
(2003)
J Physiol
, vol.552
, pp. 335-344
-
-
Turrens, J.F.1
-
82
-
-
77649196117
-
Integration of ER stress, oxidative stress and the inflammatory response in health and disease
-
K. Zhang Integration of ER stress, oxidative stress and the inflammatory response in health and disease Int J Clin Exp Med 3 2010 33 40
-
(2010)
Int J Clin Exp Med
, vol.3
, pp. 33-40
-
-
Zhang, K.1
-
83
-
-
56949089426
-
Coupling mitochondrial dysfunction to endoplasmic reticulum stress response: A molecular mechanism leading to hepatic insulin resistance
-
J.H. Lim, H.J. Lee, M. Ho Jung, and J. Song Coupling mitochondrial dysfunction to endoplasmic reticulum stress response: a molecular mechanism leading to hepatic insulin resistance Cell Signal 21 2009 169 177
-
(2009)
Cell Signal
, vol.21
, pp. 169-177
-
-
Lim, J.H.1
Lee, H.J.2
Ho Jung, M.3
Song, J.4
-
84
-
-
84897421970
-
The Nrf2 regulatory network provides an interface between redox and intermediary metabolism
-
J.D. Hayes, and A.T. Dinkova-Kostova The Nrf2 regulatory network provides an interface between redox and intermediary metabolism Trends Biochem Sci 39 2014 199 218
-
(2014)
Trends Biochem Sci
, vol.39
, pp. 199-218
-
-
Hayes, J.D.1
Dinkova-Kostova, A.T.2
-
85
-
-
84898874270
-
Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis
-
T. Wu, F. Zhao, B. Gao, C. Tan, N. Yagishita, and T. Nakajima Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis Genes Dev 28 2014 708 722
-
(2014)
Genes Dev
, vol.28
, pp. 708-722
-
-
Wu, T.1
Zhao, F.2
Gao, B.3
Tan, C.4
Yagishita, N.5
Nakajima, T.6
-
86
-
-
72649103895
-
Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis
-
S. Chowdhry, M.H. Nazmy, P.J. Meakin, A.T. Dinkova-Kostova, S.V. Walsh, and T. Tsujita Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis Free Radic Biol Med 48 2010 357 371
-
(2010)
Free Radic Biol Med
, vol.48
, pp. 357-371
-
-
Chowdhry, S.1
Nazmy, M.H.2
Meakin, P.J.3
Dinkova-Kostova, A.T.4
Walsh, S.V.5
Tsujita, T.6
-
87
-
-
76749149157
-
Deletion of nuclear factor-E2-related factor-2 leads to rapid onset and progression of nutritional steatohepatitis in mice
-
H. Sugimoto, K. Okada, J. Shoda, E. Warabi, K. Ishige, and T. Ueda Deletion of nuclear factor-E2-related factor-2 leads to rapid onset and progression of nutritional steatohepatitis in mice Am J Physiol Gastrointest Liver Physiol 298 2010 G283 G294
-
(2010)
Am J Physiol Gastrointest Liver Physiol
, vol.298
, pp. G283-G294
-
-
Sugimoto, H.1
Okada, K.2
Shoda, J.3
Warabi, E.4
Ishige, K.5
Ueda, T.6
-
88
-
-
77957311822
-
The unfolded protein response is required to maintain the integrity of the endoplasmic reticulum, prevent oxidative stress and preserve differentiation in beta-cells
-
R.J. Kaufman, S.H. Back, B. Song, J. Han, and J. Hassler The unfolded protein response is required to maintain the integrity of the endoplasmic reticulum, prevent oxidative stress and preserve differentiation in beta-cells Diabetes Obes Metab 12 Suppl. 2 2010 99 107
-
(2010)
Diabetes Obes Metab
, vol.12
, pp. 99-107
-
-
Kaufman, R.J.1
Back, S.H.2
Song, B.3
Han, J.4
Hassler, J.5
-
89
-
-
0842266604
-
Oxidative protein folding in eukaryotes: Mechanisms and consequences
-
B.P. Tu, and J.S. Weissman Oxidative protein folding in eukaryotes: mechanisms and consequences J Cell Biol 164 2004 341 346
-
(2004)
J Cell Biol
, vol.164
, pp. 341-346
-
-
Tu, B.P.1
Weissman, J.S.2
-
91
-
-
79954421880
-
The binary switch that controls the life and death decisions of ER stressed beta cells
-
C.M. Oslowski, and F. Urano The binary switch that controls the life and death decisions of ER stressed beta cells Curr Opin Cell Biol 23 2011 207 215
-
(2011)
Curr Opin Cell Biol
, vol.23
, pp. 207-215
-
-
Oslowski, C.M.1
Urano, F.2
-
92
-
-
1842843860
-
Coupling endoplasmic reticulum stress to the cell death program
-
R.V. Rao, H.M. Ellerby, and D.E. Bredesen Coupling endoplasmic reticulum stress to the cell death program Cell Death Differ 11 2004 372 380
-
(2004)
Cell Death Differ
, vol.11
, pp. 372-380
-
-
Rao, R.V.1
Ellerby, H.M.2
Bredesen, D.E.3
-
93
-
-
0035947778
-
Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha
-
I. Novoa, H. Zeng, H.P. Harding, and D. Ron Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha J Cell Biol 153 2001 1011 1022
-
(2001)
J Cell Biol
, vol.153
, pp. 1011-1022
-
-
Novoa, I.1
Zeng, H.2
Harding, H.P.3
Ron, D.4
-
94
-
-
0035957929
-
Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress
-
T. Yoneda, K. Imaizumi, K. Oono, D. Yui, F. Gomi, and T. Katayama Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress J Biol Chem 276 2001 13935 13940
-
(2001)
J Biol Chem
, vol.276
, pp. 13935-13940
-
-
Yoneda, T.1
Imaizumi, K.2
Oono, K.3
Yui, D.4
Gomi, F.5
Katayama, T.6
-
95
-
-
84859232387
-
Ero1alpha regulates Ca(2 +) fluxes at the endoplasmic reticulum-mitochondria interface (MAM)
-
T. Anelli, L. Bergamelli, E. Margittai, A. Rimessi, C. Fagioli, and A. Malgaroli Ero1alpha regulates Ca(2 +) fluxes at the endoplasmic reticulum-mitochondria interface (MAM) Antioxid Redox Signal 16 2012 1077 1087
-
(2012)
Antioxid Redox Signal
, vol.16
, pp. 1077-1087
-
-
Anelli, T.1
Bergamelli, L.2
Margittai, E.3
Rimessi, A.4
Fagioli, C.5
Malgaroli, A.6
-
96
-
-
83555176031
-
Endoplasmic reticulum: ER stress regulates mitochondrial bioenergetics
-
R. Bravo, T. Gutierrez, F. Paredes, D. Gatica, A.E. Rodriguez, and Z. Pedrozo Endoplasmic reticulum: ER stress regulates mitochondrial bioenergetics Int J Biochem Cell Biol 44 2012 16 20
-
(2012)
Int J Biochem Cell Biol
, vol.44
, pp. 16-20
-
-
Bravo, R.1
Gutierrez, T.2
Paredes, F.3
Gatica, D.4
Rodriguez, A.E.5
Pedrozo, Z.6
-
97
-
-
38649124615
-
Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease
-
P. Puri, F. Mirshahi, O. Cheung, R. Natarajan, J.W. Maher, and J.M. Kellum Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease Gastroenterology 134 2008 568 576
-
(2008)
Gastroenterology
, vol.134
, pp. 568-576
-
-
Puri, P.1
Mirshahi, F.2
Cheung, O.3
Natarajan, R.4
Maher, J.W.5
Kellum, J.M.6
-
98
-
-
78650826465
-
Endoplasmic reticulum chaperon tauroursodeoxycholic acid alleviates obesity-induced myocardial contractile dysfunction
-
A.F. Ceylan-Isik, N. Sreejayan, and J. Ren Endoplasmic reticulum chaperon tauroursodeoxycholic acid alleviates obesity-induced myocardial contractile dysfunction J Mol Cell Cardiol 50 2011 107 116
-
(2011)
J Mol Cell Cardiol
, vol.50
, pp. 107-116
-
-
Ceylan-Isik, A.F.1
Sreejayan, N.2
Ren, J.3
-
99
-
-
84903544457
-
Tauroursodeoxycholic acid attenuates progression of steatohepatitis in mice fed a methionine-choline-deficient diet
-
E.J. Cho, J.H. Yoon, M.S. Kwak, E.S. Jang, J.H. Lee, and S.J. Yu Tauroursodeoxycholic acid attenuates progression of steatohepatitis in mice fed a methionine-choline-deficient diet Dig Dis Sci 59 2014 1461 1474
-
(2014)
Dig Dis Sci
, vol.59
, pp. 1461-1474
-
-
Cho, E.J.1
Yoon, J.H.2
Kwak, M.S.3
Jang, E.S.4
Lee, J.H.5
Yu, S.J.6
-
100
-
-
79551510124
-
The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1alpha/ATF6alpha complex
-
J. Wu, J.L. Ruas, J.L. Estall, K.A. Rasbach, J.H. Choi, and L. Ye The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1alpha/ATF6alpha complex Cell Metab 13 2011 160 169
-
(2011)
Cell Metab
, vol.13
, pp. 160-169
-
-
Wu, J.1
Ruas, J.L.2
Estall, J.L.3
Rasbach, K.A.4
Choi, J.H.5
Ye, L.6
-
101
-
-
77957316569
-
Restoring endoplasmic reticulum function by chemical chaperones: An emerging therapeutic approach for metabolic diseases
-
F. Engin, and G.S. Hotamisligil Restoring endoplasmic reticulum function by chemical chaperones: an emerging therapeutic approach for metabolic diseases Diabetes Obes Metab 12 Suppl. 2 2010 108 115
-
(2010)
Diabetes Obes Metab
, vol.12
, pp. 108-115
-
-
Engin, F.1
Hotamisligil, G.S.2
-
102
-
-
71549152580
-
Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis
-
E. Erbay, V.R. Babaev, J.R. Mayers, L. Makowski, K.N. Charles, and M.E. Snitow Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis Nat Med 15 2009 1383 1391
-
(2009)
Nat Med
, vol.15
, pp. 1383-1391
-
-
Erbay, E.1
Babaev, V.R.2
Mayers, J.R.3
Makowski, L.4
Charles, K.N.5
Snitow, M.E.6
-
103
-
-
77955411159
-
Tauroursodeoxycholic acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women
-
M. Kars, L. Yang, M.F. Gregor, B.S. Mohammed, T.A. Pietka, and B.N. Finck Tauroursodeoxycholic acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women Diabetes 59 2010 1899 1905
-
(2010)
Diabetes
, vol.59
, pp. 1899-1905
-
-
Kars, M.1
Yang, L.2
Gregor, M.F.3
Mohammed, B.S.4
Pietka, T.A.5
Finck, B.N.6
-
104
-
-
84924612859
-
Physical exercise antagonizes clinical and anatomical features characterizing Lieber-DeCarli diet-induced obesity and related metabolic disorders
-
I.O. Goncalves, E. Passos, S. Rocha-Rodrigues, J.R. Torrella, E. Santos-Alves, and P. Portincasa Physical exercise antagonizes clinical and anatomical features characterizing Lieber-DeCarli diet-induced obesity and related metabolic disorders Clin Nutr 34 2015 241 247
-
(2015)
Clin Nutr
, vol.34
, pp. 241-247
-
-
Goncalves, I.O.1
Passos, E.2
Rocha-Rodrigues, S.3
Torrella, J.R.4
Santos-Alves, E.5
Portincasa, P.6
-
105
-
-
84925026377
-
Exercise-induced lung cancer regression: Mechanistic findings from a mouse model
-
K.A. Higgins, D. Park, G.Y. Lee, W.J. Curran, and X. Deng Exercise-induced lung cancer regression: mechanistic findings from a mouse model Cancer 120 2014 3302 3310
-
(2014)
Cancer
, vol.120
, pp. 3302-3310
-
-
Higgins, K.A.1
Park, D.2
Lee, G.Y.3
Curran, W.J.4
Deng, X.5
-
106
-
-
78650035561
-
Endurance training reverts heart mitochondrial dysfunction, permeability transition and apoptotic signaling in long-term severe hyperglycemia
-
J. Lumini-Oliveira, J. Magalhaes, C.V. Pereira, A.C. Moreira, P.J. Oliveira, and A. Ascensao Endurance training reverts heart mitochondrial dysfunction, permeability transition and apoptotic signaling in long-term severe hyperglycemia Mitochondrion 11 2011 54 63
-
(2011)
Mitochondrion
, vol.11
, pp. 54-63
-
-
Lumini-Oliveira, J.1
Magalhaes, J.2
Pereira, C.V.3
Moreira, A.C.4
Oliveira, P.J.5
Ascensao, A.6
-
107
-
-
0036725164
-
Effect of tauroursodeoxycholic acid on endoplasmic reticulum stress-induced caspase-12 activation
-
Q. Xie, V.I. Khaoustov, C.C. Chung, J. Sohn, B. Krishnan, and D.E. Lewis Effect of tauroursodeoxycholic acid on endoplasmic reticulum stress-induced caspase-12 activation Hepatology 36 2002 592 601
-
(2002)
Hepatology
, vol.36
, pp. 592-601
-
-
Xie, Q.1
Khaoustov, V.I.2
Chung, C.C.3
Sohn, J.4
Krishnan, B.5
Lewis, D.E.6
-
108
-
-
84855966721
-
Role of endoplasmic reticulum stress in metabolic disease and other disorders
-
L. Ozcan, and I. Tabas Role of endoplasmic reticulum stress in metabolic disease and other disorders Annu Rev Med 63 2012 317 328
-
(2012)
Annu Rev Med
, vol.63
, pp. 317-328
-
-
Ozcan, L.1
Tabas, I.2
-
109
-
-
62749178966
-
Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss
-
M.F. Gregor, L. Yang, E. Fabbrini, B.S. Mohammed, J.C. Eagon, and G.S. Hotamisligil Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss Diabetes 58 2009 693 700
-
(2009)
Diabetes
, vol.58
, pp. 693-700
-
-
Gregor, M.F.1
Yang, L.2
Fabbrini, E.3
Mohammed, B.S.4
Eagon, J.C.5
Hotamisligil, G.S.6
-
110
-
-
75849164134
-
Three weeks voluntary running wheel exercise increases endoplasmic reticulum stress in the brain of mice
-
Y. Kim, M. Park, S. Boghossian, and D.A. York Three weeks voluntary running wheel exercise increases endoplasmic reticulum stress in the brain of mice Brain Res 1317 2010 13 23
-
(2010)
Brain Res
, vol.1317
, pp. 13-23
-
-
Kim, Y.1
Park, M.2
Boghossian, S.3
York, D.A.4
-
111
-
-
33748069813
-
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
-
U. Ozcan, E. Yilmaz, L. Ozcan, M. Furuhashi, E. Vaillancourt, and R.O. Smith Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes Science 313 2006 1137 1140
-
(2006)
Science
, vol.313
, pp. 1137-1140
-
-
Ozcan, U.1
Yilmaz, E.2
Ozcan, L.3
Furuhashi, M.4
Vaillancourt, E.5
Smith, R.O.6
-
112
-
-
84921802810
-
New research developments and insights from metabolism
-
O.M. Farr, M. Camp, and C.S. Mantzoros New research developments and insights from metabolism Metabolism 64 2015 354 367
-
(2015)
Metabolism
, vol.64
, pp. 354-367
-
-
Farr, O.M.1
Camp, M.2
Mantzoros, C.S.3
-
113
-
-
33947235594
-
Exercise-induced cardioprotection - Biochemical, morphological and functional evidence in whole tissue and isolated mitochondria
-
A. Ascensao, R. Ferreira, and J. Magalhaes Exercise-induced cardioprotection - biochemical, morphological and functional evidence in whole tissue and isolated mitochondria Int J Cardiol 117 2007 16 30
-
(2007)
Int J Cardiol
, vol.117
, pp. 16-30
-
-
Ascensao, A.1
Ferreira, R.2
Magalhaes, J.3
-
114
-
-
77954192215
-
Effect of exercise training on chronic inflammation
-
K.M. Beavers, T.E. Brinkley, and B.J. Nicklas Effect of exercise training on chronic inflammation Clin Chim Acta 411 2010 785 793
-
(2010)
Clin Chim Acta
, vol.411
, pp. 785-793
-
-
Beavers, K.M.1
Brinkley, T.E.2
Nicklas, B.J.3
-
115
-
-
84888198784
-
Exercise reduces inflammation and oxidative stress in obesity-related liver diseases
-
S. Oh, K. Tanaka, E. Warabi, and J. Shoda Exercise reduces inflammation and oxidative stress in obesity-related liver diseases Med Sci Sports Exerc 45 2013 2214 2222
-
(2013)
Med Sci Sports Exerc
, vol.45
, pp. 2214-2222
-
-
Oh, S.1
Tanaka, K.2
Warabi, E.3
Shoda, J.4
-
116
-
-
34548618130
-
Exercise decreases oxidative stress and inflammation and restores renal dopamine D1 receptor function in old rats
-
M. Asghar, L. George, and M.F. Lokhandwala Exercise decreases oxidative stress and inflammation and restores renal dopamine D1 receptor function in old rats Am J Physiol Renal Physiol 293 2007 F914 F919
-
(2007)
Am J Physiol Renal Physiol
, vol.293
, pp. F914-F919
-
-
Asghar, M.1
George, L.2
Lokhandwala, M.F.3
-
117
-
-
84866645959
-
Impaired transcriptional activity of Nrf2 in age-related myocardial oxidative stress is reversible by moderate exercise training
-
S.S. Gounder, S. Kannan, D. Devadoss, C.J. Miller, K.S. Whitehead, and S.J. Odelberg Impaired transcriptional activity of Nrf2 in age-related myocardial oxidative stress is reversible by moderate exercise training PLoS One 7 2012 e45697
-
(2012)
PLoS One
, vol.7
, pp. e45697
-
-
Gounder, S.S.1
Kannan, S.2
Devadoss, D.3
Miller, C.J.4
Whitehead, K.S.5
Odelberg, S.J.6
-
118
-
-
84863873773
-
Exercise training attenuates hepatic inflammation, fibrosis and macrophage infiltration during diet induced-obesity in mice
-
N. Kawanishi, H. Yano, T. Mizokami, M. Takahashi, E. Oyanagi, and K. Suzuki Exercise training attenuates hepatic inflammation, fibrosis and macrophage infiltration during diet induced-obesity in mice Brain Behav Immun 26 2012 931 941
-
(2012)
Brain Behav Immun
, vol.26
, pp. 931-941
-
-
Kawanishi, N.1
Yano, H.2
Mizokami, T.3
Takahashi, M.4
Oyanagi, E.5
Suzuki, K.6
-
119
-
-
60349095336
-
Exercise training decreases proinflammatory profile in Zucker diabetic (type 2) fatty rats
-
E. Teixeira de Lemos, F. Reis, S. Baptista, R. Pinto, B. Sepodes, and H. Vala Exercise training decreases proinflammatory profile in Zucker diabetic (type 2) fatty rats Nutrition 25 2009 330 339
-
(2009)
Nutrition
, vol.25
, pp. 330-339
-
-
Teixeira De Lemos, E.1
Reis, F.2
Baptista, S.3
Pinto, R.4
Sepodes, B.5
Vala, H.6
-
120
-
-
75749084440
-
A 12-week aerobic exercise program reduces hepatic fat accumulation and insulin resistance in obese, Hispanic adolescents
-
G.J. van der Heijden, Z.J. Wang, Z.D. Chu, P.J. Sauer, M.W. Haymond, and L.M. Rodriguez A 12-week aerobic exercise program reduces hepatic fat accumulation and insulin resistance in obese, Hispanic adolescents Obesity (Silver Spring) 18 2010 384 390
-
(2010)
Obesity (Silver Spring)
, vol.18
, pp. 384-390
-
-
Van Der Heijden, G.J.1
Wang, Z.J.2
Chu, Z.D.3
Sauer, P.J.4
Haymond, M.W.5
Rodriguez, L.M.6
-
121
-
-
65249156393
-
Rats selectively bred for low aerobic capacity have reduced hepatic mitochondrial oxidative capacity and susceptibility to hepatic steatosis and injury
-
J.P. Thyfault, R.S. Rector, G.M. Uptergrove, S.J. Borengasser, E.M. Morris, and Y. Wei Rats selectively bred for low aerobic capacity have reduced hepatic mitochondrial oxidative capacity and susceptibility to hepatic steatosis and injury J Physiol 587 2009 1805 1816
-
(2009)
J Physiol
, vol.587
, pp. 1805-1816
-
-
Thyfault, J.P.1
Rector, R.S.2
Uptergrove, G.M.3
Borengasser, S.J.4
Morris, E.M.5
Wei, Y.6
-
122
-
-
84863307348
-
Short-term exercise reduces markers of hepatocyte apoptosis in nonalcoholic fatty liver disease
-
C.E. Fealy, J.M. Haus, T.P. Solomon, M. Pagadala, C.A. Flask, and A.J. McCullough Short-term exercise reduces markers of hepatocyte apoptosis in nonalcoholic fatty liver disease J Appl Physiol 113 2012 1 6
-
(2012)
J Appl Physiol
, vol.113
, pp. 1-6
-
-
Fealy, C.E.1
Haus, J.M.2
Solomon, T.P.3
Pagadala, M.4
Flask, C.A.5
McCullough, A.J.6
-
123
-
-
84896419010
-
IL-15 expression increased in response to treadmill running and inhibited endoplasmic reticulum stress in skeletal muscle in rats
-
H.T. Yang, L.J. Luo, W.J. Chen, L. Zhao, C.S. Tang, and Y.F. Qi IL-15 expression increased in response to treadmill running and inhibited endoplasmic reticulum stress in skeletal muscle in rats Endocrine 2014
-
(2014)
Endocrine
-
-
Yang, H.T.1
Luo, L.J.2
Chen, W.J.3
Zhao, L.4
Tang, C.S.5
Qi, Y.F.6
-
124
-
-
84879409811
-
Endurance training in mice increases the unfolded protein response induced by a high-fat diet
-
L. Deldicque, P.D. Cani, N.M. Delzenne, K. Baar, and M. Francaux Endurance training in mice increases the unfolded protein response induced by a high-fat diet J Physiol Biochem 69 2013 215 225
-
(2013)
J Physiol Biochem
, vol.69
, pp. 215-225
-
-
Deldicque, L.1
Cani, P.D.2
Delzenne, N.M.3
Baar, K.4
Francaux, M.5
-
125
-
-
35348827324
-
That which does not kill me makes me stronger: Adapting to chronic ER stress
-
D.T. Rutkowski, and R.J. Kaufman That which does not kill me makes me stronger: adapting to chronic ER stress Trends Biochem Sci 32 2007 469 476
-
(2007)
Trends Biochem Sci
, vol.32
, pp. 469-476
-
-
Rutkowski, D.T.1
Kaufman, R.J.2
-
126
-
-
84899764290
-
Molecular mechanisms and new treatment strategies for non-alcoholic steatohepatitis (NASH)
-
A. Takaki, D. Kawai, and K. Yamamoto Molecular mechanisms and new treatment strategies for non-alcoholic steatohepatitis (NASH) Int J Mol Sci 15 2014 7352 7379
-
(2014)
Int J Mol Sci
, vol.15
, pp. 7352-7379
-
-
Takaki, A.1
Kawai, D.2
Yamamoto, K.3
-
127
-
-
79251551381
-
Regular physical exercise training assists in preventing type 2 diabetes development: Focus on its antioxidant and anti-inflammatory properties
-
E. Teixeira-Lemos, S. Nunes, F. Teixeira, and F. Reis Regular physical exercise training assists in preventing type 2 diabetes development: focus on its antioxidant and anti-inflammatory properties Cardiovasc Diabetol 10 2011 12
-
(2011)
Cardiovasc Diabetol
, vol.10
, pp. 12
-
-
Teixeira-Lemos, E.1
Nunes, S.2
Teixeira, F.3
Reis, F.4
-
128
-
-
0038677039
-
Exercise and physical activity in the prevention and treatment of atherosclerotic cardiovascular disease: A statement from the Council on Clinical Cardiology (Subcommittee on Exercise, Rehabilitation, and Prevention) and the Council on Nutrition, Physical Activity, and Metabolism (Subcommittee on Physical Activity)
-
P.D. Thompson, D. Buchner, I.L. Pina, G.J. Balady, M.A. Williams, and B.H. Marcus Exercise and physical activity in the prevention and treatment of atherosclerotic cardiovascular disease: a statement from the Council on Clinical Cardiology (Subcommittee on Exercise, Rehabilitation, and Prevention) and the Council on Nutrition, Physical Activity, and Metabolism (Subcommittee on Physical Activity) Circulation 107 2003 3109 3116
-
(2003)
Circulation
, vol.107
, pp. 3109-3116
-
-
Thompson, P.D.1
Buchner, D.2
Pina, I.L.3
Balady, G.J.4
Williams, M.A.5
Marcus, B.H.6
|