메뉴 건너뛰기




Volumn 43, Issue 11, 2013, Pages 1184-1194

Exercise as a therapeutic tool to prevent mitochondrial degeneration in nonalcoholic steatohepatitis

Author keywords

Mitochondrial function; Physical (in)activity; Training; Treatment

Indexed keywords

ANTILIPEMIC AGENT; ANTIOBESITY AGENT; CASPASE 3; CASPASE 7; CATALASE; CYTOCHROME C; CYTOKERATIN 18; GLUTATHIONE; INSULIN SENSITIZING AGENT; REACTIVE OXYGEN METABOLITE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; SUPEROXIDE DISMUTASE; THIOREDOXIN;

EID: 84885421216     PISSN: 00142972     EISSN: 13652362     Source Type: Journal    
DOI: 10.1111/eci.12146     Document Type: Review
Times cited : (36)

References (114)
  • 3
    • 32844458032 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in NASH: causes, consequences and possible means to prevent it
    • Begriche K, Igoudjil A, Pessayre D, Fromenty B. Mitochondrial dysfunction in NASH: causes, consequences and possible means to prevent it. Mitochondrion 2006;6:1-28.
    • (2006) Mitochondrion , vol.6 , pp. 1-28
    • Begriche, K.1    Igoudjil, A.2    Pessayre, D.3    Fromenty, B.4
  • 4
    • 18844389970 scopus 로고    scopus 로고
    • NASH: a mitochondrial disease
    • Pessayre D, Fromenty B. NASH: a mitochondrial disease. J Hepatol 2005;42:928-40.
    • (2005) J Hepatol , vol.42 , pp. 928-940
    • Pessayre, D.1    Fromenty, B.2
  • 7
    • 33947235594 scopus 로고    scopus 로고
    • Exercise-induced cardioprotection-biochemical, morphological and functional evidence in whole tissue and isolated mitochondria
    • Ascensao A, Ferreira R, Magalhaes J. Exercise-induced cardioprotection-biochemical, morphological and functional evidence in whole tissue and isolated mitochondria. Int J Cardiol 2007;117:16-30.
    • (2007) Int J Cardiol , vol.117 , pp. 16-30
    • Ascensao, A.1    Ferreira, R.2    Magalhaes, J.3
  • 8
    • 49949103399 scopus 로고    scopus 로고
    • Beneficial effects of exercise on muscle mitochondrial function in diabetes mellitus
    • Lumini JA, Magalhaes J, Oliveira PJ, Ascensao A. Beneficial effects of exercise on muscle mitochondrial function in diabetes mellitus. Sports Med 2008;38:735-50.
    • (2008) Sports Med , vol.38 , pp. 735-750
    • Lumini, J.A.1    Magalhaes, J.2    Oliveira, P.J.3    Ascensao, A.4
  • 10
    • 37849049214 scopus 로고    scopus 로고
    • Exercise-induced cardioprotection against myocardial ischemia-reperfusion injury
    • Powers SK, Quindry JC, Kavazis AN. Exercise-induced cardioprotection against myocardial ischemia-reperfusion injury. Free Radic Biol Med 2008;44:193-201.
    • (2008) Free Radic Biol Med , vol.44 , pp. 193-201
    • Powers, S.K.1    Quindry, J.C.2    Kavazis, A.N.3
  • 11
    • 84856821421 scopus 로고    scopus 로고
    • Exercise training improves body composition, blood lipid profile and serum insulin levels in obese children
    • Zorba E, Cengiz T, Karacabey K. Exercise training improves body composition, blood lipid profile and serum insulin levels in obese children. J Sports Med Phys Fitness 2011;51:664-9.
    • (2011) J Sports Med Phys Fitness , vol.51 , pp. 664-669
    • Zorba, E.1    Cengiz, T.2    Karacabey, K.3
  • 12
    • 0034133328 scopus 로고    scopus 로고
    • The spectrum of nonalcoholic fatty liver disease: from steatosis to nonalcoholic steatohepatitis
    • 101-4.
    • Saadeh S, Younossi ZM. The spectrum of nonalcoholic fatty liver disease: from steatosis to nonalcoholic steatohepatitis. Cleve Clin J Med 2000;67:96-7, 101-4.
    • (2000) Cleve Clin J Med , vol.67 , pp. 96-97
    • Saadeh, S.1    Younossi, Z.M.2
  • 13
    • 84861329163 scopus 로고    scopus 로고
    • Independent association between nonalcoholic fatty liver disease and cardiovascular disease in the US population
    • Stepanova M, Younossi ZM. Independent association between nonalcoholic fatty liver disease and cardiovascular disease in the US population. Clin Gastroenterol Hepatol 2012;10:646-50.
    • (2012) Clin Gastroenterol Hepatol , vol.10 , pp. 646-650
    • Stepanova, M.1    Younossi, Z.M.2
  • 14
    • 10644220306 scopus 로고    scopus 로고
    • Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity
    • Browning JD, Szczepaniak LS, Dobbins R, Nuremberg P, Horton JD, Cohen JC et al. Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology 2004;40:1387-95.
    • (2004) Hepatology , vol.40 , pp. 1387-1395
    • Browning, J.D.1    Szczepaniak, L.S.2    Dobbins, R.3    Nuremberg, P.4    Horton, J.D.5    Cohen, J.C.6
  • 16
    • 17444417085 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • Adams LA, Angulo P, Lindor KD. Nonalcoholic fatty liver disease. CMAJ 2005;172:899-905.
    • (2005) CMAJ , vol.172 , pp. 899-905
    • Adams, L.A.1    Angulo, P.2    Lindor, K.D.3
  • 17
    • 0036829092 scopus 로고    scopus 로고
    • AGA technical review on nonalcoholic fatty liver disease
    • Sanyal AJ. AGA technical review on nonalcoholic fatty liver disease. Gastroenterology 2002;123:1705-25.
    • (2002) Gastroenterology , vol.123 , pp. 1705-1725
    • Sanyal, A.J.1
  • 18
    • 0034089687 scopus 로고    scopus 로고
    • Prevalence of abnormal serum aminotransferase values in overweight and obese adolescents
    • Strauss RS, Barlow SE, Dietz WH. Prevalence of abnormal serum aminotransferase values in overweight and obese adolescents. J Pediatr 2000;136:727-33.
    • (2000) J Pediatr , vol.136 , pp. 727-733
    • Strauss, R.S.1    Barlow, S.E.2    Dietz, W.H.3
  • 19
    • 33846529926 scopus 로고    scopus 로고
    • Noninvasive indices of fibrosis in NAFLD: starting to think about a three-hit (at least) phenomenon
    • Charlton M. Noninvasive indices of fibrosis in NAFLD: starting to think about a three-hit (at least) phenomenon. Am J Gastroenterol 2007;102:409-11.
    • (2007) Am J Gastroenterol , vol.102 , pp. 409-411
    • Charlton, M.1
  • 20
    • 0031947715 scopus 로고    scopus 로고
    • Steatohepatitis: a tale of two "hits"?
    • Day CP, James OF. Steatohepatitis: a tale of two "hits"? Gastroenterology 1998;114:842-5.
    • (1998) Gastroenterology , vol.114 , pp. 842-845
    • Day, C.P.1    James, O.F.2
  • 21
    • 30044431801 scopus 로고    scopus 로고
    • From fat to inflammation
    • Day CP. From fat to inflammation. Gastroenterology 2006;130:207-10.
    • (2006) Gastroenterology , vol.130 , pp. 207-210
    • Day, C.P.1
  • 22
    • 85047692761 scopus 로고    scopus 로고
    • Lipid peroxidation and oxidant stress regulate hepatic apolipoprotein B degradation and VLDL production
    • Pan M, Cederbaum AI, Zhang YL, Ginsberg HN, Williams KJ, Fisher EA. Lipid peroxidation and oxidant stress regulate hepatic apolipoprotein B degradation and VLDL production. J Clin Invest 2004;113:1277-87.
    • (2004) J Clin Invest , vol.113 , pp. 1277-1287
    • Pan, M.1    Cederbaum, A.I.2    Zhang, Y.L.3    Ginsberg, H.N.4    Williams, K.J.5    Fisher, E.A.6
  • 23
    • 77951632831 scopus 로고    scopus 로고
    • Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model
    • Rector RS, Thyfault JP, Uptergrove GM, Morris EM, Naples SP, Borengasser SJ et al. Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model. J Hepatol 2010;52:727-36.
    • (2010) J Hepatol , vol.52 , pp. 727-736
    • Rector, R.S.1    Thyfault, J.P.2    Uptergrove, G.M.3    Morris, E.M.4    Naples, S.P.5    Borengasser, S.J.6
  • 24
    • 56649083495 scopus 로고    scopus 로고
    • Mechanisms of disease progression in nonalcoholic fatty liver disease
    • Jou J, Choi SS, Diehl AM. Mechanisms of disease progression in nonalcoholic fatty liver disease. Semin Liver Dis 2008;28:370-9.
    • (2008) Semin Liver Dis , vol.28 , pp. 370-379
    • Jou, J.1    Choi, S.S.2    Diehl, A.M.3
  • 26
  • 27
    • 36949083936 scopus 로고
    • Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism
    • Mitchell P. Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism. Nature 1961;191:144-8.
    • (1961) Nature , vol.191 , pp. 144-148
    • Mitchell, P.1
  • 28
    • 0036960328 scopus 로고    scopus 로고
    • Mitochondrial membrane potential in cardiac myocytes
    • Skarka L, Ostadal B. Mitochondrial membrane potential in cardiac myocytes. Physiol Res 2002;51:425-34.
    • (2002) Physiol Res , vol.51 , pp. 425-434
    • Skarka, L.1    Ostadal, B.2
  • 29
    • 84860124421 scopus 로고    scopus 로고
    • Strategic role for mitochondria in Alzheimer's disease and cancer
    • Hedskog L, Zhang S, Ankarcrona M. Strategic role for mitochondria in Alzheimer's disease and cancer. Antioxid Redox Signal 2012;16:1476-91.
    • (2012) Antioxid Redox Signal , vol.16 , pp. 1476-1491
    • Hedskog, L.1    Zhang, S.2    Ankarcrona, M.3
  • 30
    • 77955418014 scopus 로고    scopus 로고
    • Mitochondria, spermatogenesis and male infertility
    • Rajender S, Rahul P, Mahdi AA. Mitochondria, spermatogenesis and male infertility. Mitochondrion 2010;10:419-28.
    • (2010) Mitochondrion , vol.10 , pp. 419-428
    • Rajender, S.1    Rahul, P.2    Mahdi, A.A.3
  • 32
    • 84856415487 scopus 로고    scopus 로고
    • The role of mitochondria in insulin resistance and type 2 diabetes mellitus
    • Szendroedi J, Phielix E, Roden M. The role of mitochondria in insulin resistance and type 2 diabetes mellitus. Nat Rev Endocrinol 2012;8:92-103.
    • (2012) Nat Rev Endocrinol , vol.8 , pp. 92-103
    • Szendroedi, J.1    Phielix, E.2    Roden, M.3
  • 34
    • 0023947327 scopus 로고
    • Evidence for mitochondrial DNA damage by lipid peroxidation
    • Hruszkewycz AM. Evidence for mitochondrial DNA damage by lipid peroxidation. Biochem Biophys Res Commun 1988;153:191-7.
    • (1988) Biochem Biophys Res Commun , vol.153 , pp. 191-197
    • Hruszkewycz, A.M.1
  • 35
    • 37549030853 scopus 로고    scopus 로고
    • Cytoplasmic fine granular expression of 8-hydroxydeoxyguanosine reflects early mitochondrial oxidative DNA damage in nonalcoholic fatty liver disease
    • Nomoto K, Tsuneyama K, Takahashi H, Murai Y, Takano Y. Cytoplasmic fine granular expression of 8-hydroxydeoxyguanosine reflects early mitochondrial oxidative DNA damage in nonalcoholic fatty liver disease. Appl Immunohistochem Mol Morphol 2008;16:71-5.
    • (2008) Appl Immunohistochem Mol Morphol , vol.16 , pp. 71-75
    • Nomoto, K.1    Tsuneyama, K.2    Takahashi, H.3    Murai, Y.4    Takano, Y.5
  • 36
    • 33644897340 scopus 로고    scopus 로고
    • Pathogenesis of nonalcoholic steatohepatitis (NASH)
    • Ma X, Li Z. Pathogenesis of nonalcoholic steatohepatitis (NASH). Chin J Dig Dis 2006;7:7-11.
    • (2006) Chin J Dig Dis , vol.7 , pp. 7-11
    • Ma, X.1    Li, Z.2
  • 37
    • 0037794951 scopus 로고
    • Uncoupling of oxidative phosphorylation in mitochondria from fatty livers
    • Dianzani MU. Uncoupling of oxidative phosphorylation in mitochondria from fatty livers. Biochim Biophys Acta 1954;14:514-32.
    • (1954) Biochim Biophys Acta , vol.14 , pp. 514-532
    • Dianzani, M.U.1
  • 38
    • 77649224306 scopus 로고    scopus 로고
    • Electron microscopic findings in non-alcoholic fatty liver disease: is there a difference between hepatosteatosis and steatohepatitis?
    • Ahishali E, Demir K, Ahishali B, Akyuz F, Pinarbasi B, Poturoglu S et al. Electron microscopic findings in non-alcoholic fatty liver disease: is there a difference between hepatosteatosis and steatohepatitis? J Gastroenterol Hepatol 2010;25:619-26.
    • (2010) J Gastroenterol Hepatol , vol.25 , pp. 619-626
    • Ahishali, E.1    Demir, K.2    Ahishali, B.3    Akyuz, F.4    Pinarbasi, B.5    Poturoglu, S.6
  • 39
    • 0036086130 scopus 로고    scopus 로고
    • Free radicals in the physiological control of cell function
    • Droge W. Free radicals in the physiological control of cell function. Physiol Rev 2002;82:47-95.
    • (2002) Physiol Rev , vol.82 , pp. 47-95
    • Droge, W.1
  • 40
    • 46749149676 scopus 로고    scopus 로고
    • Oxidative stress-induced risk factors associated with the metabolic syndrome: a unifying hypothesis
    • Grattagliano I, Palmieri VO, Portincasa P, Moschetta A, Palasciano G. Oxidative stress-induced risk factors associated with the metabolic syndrome: a unifying hypothesis. J Nutr Biochem 2008;19:491-504.
    • (2008) J Nutr Biochem , vol.19 , pp. 491-504
    • Grattagliano, I.1    Palmieri, V.O.2    Portincasa, P.3    Moschetta, A.4    Palasciano, G.5
  • 41
    • 84655169624 scopus 로고    scopus 로고
    • Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis
    • Rolo AP, Teodoro JS, Palmeira CM. Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis. Free Radic Biol Med 2012;52:59-69.
    • (2012) Free Radic Biol Med , vol.52 , pp. 59-69
    • Rolo, A.P.1    Teodoro, J.S.2    Palmeira, C.M.3
  • 42
    • 79956301571 scopus 로고    scopus 로고
    • The role of oxidative stress in non-alcoholic steatohepatitis
    • Koek GH, Liedorp PR, Bast A. The role of oxidative stress in non-alcoholic steatohepatitis. Clin Chim Acta 2011;412:1297-305.
    • (2011) Clin Chim Acta , vol.412 , pp. 1297-1305
    • Koek, G.H.1    Liedorp, P.R.2    Bast, A.3
  • 43
    • 0035164629 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease in an area of southern Italy: main clinical, histological, and pathophysiological aspects
    • Loguercio C, De Girolamo V, de Sio I, Tuccillo C, Ascione A, Baldi F et al. Non-alcoholic fatty liver disease in an area of southern Italy: main clinical, histological, and pathophysiological aspects. J Hepatol 2001;35:568-74.
    • (2001) J Hepatol , vol.35 , pp. 568-574
    • Loguercio, C.1    De Girolamo, V.2    de Sio, I.3    Tuccillo, C.4    Ascione, A.5    Baldi, F.6
  • 44
    • 0033520771 scopus 로고    scopus 로고
    • Alterations in liver ATP homeostasis in human nonalcoholic steatohepatitis: a pilot study
    • Cortez-Pinto H, Chatham J, Chacko VP, Arnold C, Rashid A, Diehl AM. Alterations in liver ATP homeostasis in human nonalcoholic steatohepatitis: a pilot study. JAMA 1999;282:1659-64.
    • (1999) JAMA , vol.282 , pp. 1659-1664
    • Cortez-Pinto, H.1    Chatham, J.2    Chacko, V.P.3    Arnold, C.4    Rashid, A.5    Diehl, A.M.6
  • 45
    • 18144444592 scopus 로고    scopus 로고
    • Defective hepatic mitochondrial respiratory chain in patients with nonalcoholic steatohepatitis
    • Perez-Carreras M, Del Hoyo P, Martin MA, Rubio JC, Martin A, Castellano G et al. Defective hepatic mitochondrial respiratory chain in patients with nonalcoholic steatohepatitis. Hepatology 2003;38:999-1007.
    • (2003) Hepatology , vol.38 , pp. 999-1007
    • Perez-Carreras, M.1    Del Hoyo, P.2    Martin, M.A.3    Rubio, J.C.4    Martin, A.5    Castellano, G.6
  • 46
    • 0037453055 scopus 로고    scopus 로고
    • Functional proteomics of nonalcoholic steatohepatitis: mitochondrial proteins as targets of S-adenosylmethionine
    • Santamaria E, Avila MA, Latasa MU, Rubio A, Martin-Duce A, Lu SC et al. Functional proteomics of nonalcoholic steatohepatitis: mitochondrial proteins as targets of S-adenosylmethionine. Proc Natl Acad Sci USA 2003;100:3065-70.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 3065-3070
    • Santamaria, E.1    Avila, M.A.2    Latasa, M.U.3    Rubio, A.4    Martin-Duce, A.5    Lu, S.C.6
  • 48
    • 34250759386 scopus 로고    scopus 로고
    • Oxidative stress and antioxidant defenses in serum of patients with non-alcoholic steatohepatitis
    • Baskol G, Baskol M, Kocer D. Oxidative stress and antioxidant defenses in serum of patients with non-alcoholic steatohepatitis. Clin Biochem 2007;40:776-80.
    • (2007) Clin Biochem , vol.40 , pp. 776-780
    • Baskol, G.1    Baskol, M.2    Kocer, D.3
  • 49
    • 1642292288 scopus 로고    scopus 로고
    • Antioxidant defence mechanisms: new players in the pathogenesis of non-alcoholic steatohepatitis?
    • Leclercq IA. Antioxidant defence mechanisms: new players in the pathogenesis of non-alcoholic steatohepatitis? Clin Sci (Lond) 2004;106:235-7.
    • (2004) Clin Sci (Lond) , vol.106 , pp. 235-237
    • Leclercq, I.A.1
  • 51
    • 17044370841 scopus 로고    scopus 로고
    • Glutathione metabolism and antioxidant enzymes in patients affected by nonalcoholic steatohepatitis
    • Nobili V, Pastore A, Gaeta LM, Tozzi G, Comparcola D, Sartorelli MR et al. Glutathione metabolism and antioxidant enzymes in patients affected by nonalcoholic steatohepatitis. Clin Chim Acta 2005;355:105-11.
    • (2005) Clin Chim Acta , vol.355 , pp. 105-111
    • Nobili, V.1    Pastore, A.2    Gaeta, L.M.3    Tozzi, G.4    Comparcola, D.5    Sartorelli, M.R.6
  • 52
  • 53
    • 77954373903 scopus 로고    scopus 로고
    • Identification of a novel biomarker for oxidative stress induced by hydrogen peroxide in primary human hepatocytes using the 2-nitrobenzenesulfenyl chloride isotope labeling method
    • Takami Y, Uto H, Tamai T, Sato Y, Ishida Y, Morinaga H et al. Identification of a novel biomarker for oxidative stress induced by hydrogen peroxide in primary human hepatocytes using the 2-nitrobenzenesulfenyl chloride isotope labeling method. Hepatol Res 2010;40:438-45.
    • (2010) Hepatol Res , vol.40 , pp. 438-445
    • Takami, Y.1    Uto, H.2    Tamai, T.3    Sato, Y.4    Ishida, Y.5    Morinaga, H.6
  • 54
    • 12144291550 scopus 로고    scopus 로고
    • Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients
    • Videla LA, Rodrigo R, Orellana M, Fernandez V, Tapia G, Quinones L et al. Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients. Clin Sci (Lond) 2004;106:261-8.
    • (2004) Clin Sci (Lond) , vol.106 , pp. 261-268
    • Videla, L.A.1    Rodrigo, R.2    Orellana, M.3    Fernandez, V.4    Tapia, G.5    Quinones, L.6
  • 55
    • 34447319135 scopus 로고    scopus 로고
    • Expression of genes encoding mitochondrial proteins can distinguish nonalcoholic steatosis from steatohepatitis
    • Bragoszewski P, Habior A, Walewska-Zielecka B, Ostrowski J. Expression of genes encoding mitochondrial proteins can distinguish nonalcoholic steatosis from steatohepatitis. Acta Biochim Pol 2007;54:341-8.
    • (2007) Acta Biochim Pol , vol.54 , pp. 341-348
    • Bragoszewski, P.1    Habior, A.2    Walewska-Zielecka, B.3    Ostrowski, J.4
  • 56
    • 46349087273 scopus 로고    scopus 로고
    • Uncoupling protein-2 (UCP2) induces mitochondrial proton leak and increases susceptibility of non-alcoholic steatohepatitis (NASH) liver to ischaemia-reperfusion injury
    • Serviddio G, Bellanti F, Tamborra R, Rollo T, Capitanio N, Romano AD et al. Uncoupling protein-2 (UCP2) induces mitochondrial proton leak and increases susceptibility of non-alcoholic steatohepatitis (NASH) liver to ischaemia-reperfusion injury. Gut 2008;57:957-65.
    • (2008) Gut , vol.57 , pp. 957-965
    • Serviddio, G.1    Bellanti, F.2    Tamborra, R.3    Rollo, T.4    Capitanio, N.5    Romano, A.D.6
  • 57
    • 0035986608 scopus 로고    scopus 로고
    • Possible physiological roles of mitochondrial uncoupling proteins-UCPn
    • Jezek P. Possible physiological roles of mitochondrial uncoupling proteins-UCPn. Int J Biochem Cell Biol 2002;34:1190-206.
    • (2002) Int J Biochem Cell Biol , vol.34 , pp. 1190-1206
    • Jezek, P.1
  • 58
    • 21344458172 scopus 로고    scopus 로고
    • Apoptosis in alcoholic and nonalcoholic steatohepatitis
    • Feldstein AE, Gores GJ. Apoptosis in alcoholic and nonalcoholic steatohepatitis. Front Biosci 2005;10:3093-9.
    • (2005) Front Biosci , vol.10 , pp. 3093-3099
    • Feldstein, A.E.1    Gores, G.J.2
  • 60
    • 0042165989 scopus 로고    scopus 로고
    • Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis
    • Feldstein AE, Canbay A, Angulo P, Taniai M, Burgart LJ, Lindor KD et al. Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis. Gastroenterology 2003;125:437-43.
    • (2003) Gastroenterology , vol.125 , pp. 437-443
    • Feldstein, A.E.1    Canbay, A.2    Angulo, P.3    Taniai, M.4    Burgart, L.J.5    Lindor, K.D.6
  • 61
    • 4544335155 scopus 로고    scopus 로고
    • Hepatocyte apoptosis, expression of death receptors, and activation of NF-kappaB in the liver of nonalcoholic and alcoholic steatohepatitis patients
    • Ribeiro PS, Cortez-Pinto H, Sola S, Castro RE, Ramalho RM, Baptista A et al. Hepatocyte apoptosis, expression of death receptors, and activation of NF-kappaB in the liver of nonalcoholic and alcoholic steatohepatitis patients. Am J Gastroenterol 2004;99:1708-17.
    • (2004) Am J Gastroenterol , vol.99 , pp. 1708-1717
    • Ribeiro, P.S.1    Cortez-Pinto, H.2    Sola, S.3    Castro, R.E.4    Ramalho, R.M.5    Baptista, A.6
  • 64
    • 0035830507 scopus 로고    scopus 로고
    • Apoptosis: corralling the corpses
    • Hengartner MO. Apoptosis: corralling the corpses. Cell 2001;104:325-8.
    • (2001) Cell , vol.104 , pp. 325-328
    • Hengartner, M.O.1
  • 65
    • 5144232785 scopus 로고    scopus 로고
    • Hepatocyte-specific disruption of Bcl-xL leads to continuous hepatocyte apoptosis and liver fibrotic responses
    • Takehara T, Tatsumi T, Suzuki T, Rucker EB 3rd, Hennighausen L, Jinushi M et al. Hepatocyte-specific disruption of Bcl-xL leads to continuous hepatocyte apoptosis and liver fibrotic responses. Gastroenterology 2004;127:1189-97.
    • (2004) Gastroenterology , vol.127 , pp. 1189-1197
    • Takehara, T.1    Tatsumi, T.2    Suzuki, T.3    Rucker 3rd, E.B.4    Hennighausen, L.5    Jinushi, M.6
  • 66
    • 0142151769 scopus 로고    scopus 로고
    • Kupffer cell engulfment of apoptotic bodies stimulates death ligand and cytokine expression
    • Canbay A, Feldstein AE, Higuchi H, Werneburg N, Grambihler A, Bronk SF et al. Kupffer cell engulfment of apoptotic bodies stimulates death ligand and cytokine expression. Hepatology 2003;38:1188-98.
    • (2003) Hepatology , vol.38 , pp. 1188-1198
    • Canbay, A.1    Feldstein, A.E.2    Higuchi, H.3    Werneburg, N.4    Grambihler, A.5    Bronk, S.F.6
  • 68
    • 21044445452 scopus 로고    scopus 로고
    • Apoptosis: a mechanism of acute and chronic liver injury
    • Guicciardi ME, Gores GJ. Apoptosis: a mechanism of acute and chronic liver injury. Gut 2005;54:1024-33.
    • (2005) Gut , vol.54 , pp. 1024-1033
    • Guicciardi, M.E.1    Gores, G.J.2
  • 69
    • 1242336980 scopus 로고    scopus 로고
    • Apoptosis: the nexus of liver injury and fibrosis
    • Canbay A, Friedman S, Gores GJ. Apoptosis: the nexus of liver injury and fibrosis. Hepatology 2004;39:273-8.
    • (2004) Hepatology , vol.39 , pp. 273-278
    • Canbay, A.1    Friedman, S.2    Gores, G.J.3
  • 70
    • 70350046669 scopus 로고    scopus 로고
    • Cytokeratin-18 fragment levels as noninvasive biomarkers for nonalcoholic steatohepatitis: a multicenter validation study
    • Feldstein AE, Wieckowska A, Lopez AR, Liu YC, Zein NN, McCullough AJ. Cytokeratin-18 fragment levels as noninvasive biomarkers for nonalcoholic steatohepatitis: a multicenter validation study. Hepatology 2009;50:1072-8.
    • (2009) Hepatology , vol.50 , pp. 1072-1078
    • Feldstein, A.E.1    Wieckowska, A.2    Lopez, A.R.3    Liu, Y.C.4    Zein, N.N.5    McCullough, A.J.6
  • 71
    • 79959795387 scopus 로고    scopus 로고
    • NASH: a global health problem
    • Sanyal AJ. NASH: a global health problem. Hepatol Res 2011;41:670-4.
    • (2011) Hepatol Res , vol.41 , pp. 670-674
    • Sanyal, A.J.1
  • 73
    • 77952692484 scopus 로고    scopus 로고
    • Pharmacological and non-pharmacological treatment of non-alcoholic fatty liver disease
    • Kaser S, Ebenbichler CF, Tilg H. Pharmacological and non-pharmacological treatment of non-alcoholic fatty liver disease. Int J Clin Pract 2010;64:968-83.
    • (2010) Int J Clin Pract , vol.64 , pp. 968-983
    • Kaser, S.1    Ebenbichler, C.F.2    Tilg, H.3
  • 75
    • 80054687396 scopus 로고    scopus 로고
    • Does physical inactivity cause nonalcoholic fatty liver disease?
    • Rector RS, Thyfault JP. Does physical inactivity cause nonalcoholic fatty liver disease? J Appl Physiol 2011;111:1828-35.
    • (2011) J Appl Physiol , vol.111 , pp. 1828-1835
    • Rector, R.S.1    Thyfault, J.P.2
  • 78
    • 65249156393 scopus 로고    scopus 로고
    • Rats selectively bred for low aerobic capacity have reduced hepatic mitochondrial oxidative capacity and susceptibility to hepatic steatosis and injury
    • Thyfault JP, Rector RS, Uptergrove GM, Borengasser SJ, Morris EM, Wei Y et al. Rats selectively bred for low aerobic capacity have reduced hepatic mitochondrial oxidative capacity and susceptibility to hepatic steatosis and injury. J Physiol 2009;587:1805-16.
    • (2009) J Physiol , vol.587 , pp. 1805-1816
    • Thyfault, J.P.1    Rector, R.S.2    Uptergrove, G.M.3    Borengasser, S.J.4    Morris, E.M.5    Wei, Y.6
  • 79
    • 83555176039 scopus 로고    scopus 로고
    • Lifestyle interventions for the treatment of non-alcoholic fatty liver disease in adults: a systematic review
    • Thoma C, Day CP, Trenell MI. Lifestyle interventions for the treatment of non-alcoholic fatty liver disease in adults: a systematic review. J Hepatol 2012;56:255-66.
    • (2012) J Hepatol , vol.56 , pp. 255-266
    • Thoma, C.1    Day, C.P.2    Trenell, M.I.3
  • 80
    • 19144372447 scopus 로고    scopus 로고
    • One-year intense nutritional counseling results in histological improvement in patients with non-alcoholic steatohepatitis: a pilot study
    • Huang MA, Greenson JK, Chao C, Anderson L, Peterman D, Jacobson J et al. One-year intense nutritional counseling results in histological improvement in patients with non-alcoholic steatohepatitis: a pilot study. Am J Gastroenterol 2005;100:1072-81.
    • (2005) Am J Gastroenterol , vol.100 , pp. 1072-1081
    • Huang, M.A.1    Greenson, J.K.2    Chao, C.3    Anderson, L.4    Peterman, D.5    Jacobson, J.6
  • 81
    • 73449116035 scopus 로고    scopus 로고
    • Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis
    • Promrat K, Kleiner DE, Niemeier HM, Jackvony E, Kearns M, Wands JR et al. Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis. Hepatology 2010;51:121-9.
    • (2010) Hepatology , vol.51 , pp. 121-129
    • Promrat, K.1    Kleiner, D.E.2    Niemeier, H.M.3    Jackvony, E.4    Kearns, M.5    Wands, J.R.6
  • 83
    • 84877003841 scopus 로고    scopus 로고
    • Life style modification improves insulin resistance and liver histology in patients with non-alcoholic fatty liver disease
    • Bhat G, Baba CS, Pandey A, Kumari N, Choudhuri G. Life style modification improves insulin resistance and liver histology in patients with non-alcoholic fatty liver disease. World J Hepatol 2012;4:209-17.
    • (2012) World J Hepatol , vol.4 , pp. 209-217
    • Bhat, G.1    Baba, C.S.2    Pandey, A.3    Kumari, N.4    Choudhuri, G.5
  • 84
    • 33645225309 scopus 로고    scopus 로고
    • Effect of exercise and dietary modification on serum aminotransferase levels in patients with nonalcoholic steatohepatitis
    • Sreenivasa Baba C, Alexander G, Kalyani B, Pandey R, Rastogi S, Pandey A et al. Effect of exercise and dietary modification on serum aminotransferase levels in patients with nonalcoholic steatohepatitis. J Gastroenterol Hepatol 2006;21:191-8.
    • (2006) J Gastroenterol Hepatol , vol.21 , pp. 191-198
    • Sreenivasa Baba, C.1    Alexander, G.2    Kalyani, B.3    Pandey, R.4    Rastogi, S.5    Pandey, A.6
  • 85
    • 84856030628 scopus 로고    scopus 로고
    • Putative factors that may modulate the effect of exercise on liver fat: insights from animal studies
    • Magkos F. Putative factors that may modulate the effect of exercise on liver fat: insights from animal studies. J Nutr Metab 2012;2012:827417.
    • (2012) J Nutr Metab , vol.2012 , pp. 827417
    • Magkos, F.1
  • 86
    • 77954235797 scopus 로고    scopus 로고
    • Fitness versus fatness: moving beyond weight loss in nonalcoholic fatty liver disease
    • Johnson NA, George J. Fitness versus fatness: moving beyond weight loss in nonalcoholic fatty liver disease. Hepatology 2010;52:370-81.
    • (2010) Hepatology , vol.52 , pp. 370-381
    • Johnson, N.A.1    George, J.2
  • 87
    • 46349104762 scopus 로고    scopus 로고
    • The effects of swimming exercise on high-fat-diet-induced steatohepatitis
    • He Y, Zhang H, Fu F. The effects of swimming exercise on high-fat-diet-induced steatohepatitis. J Sports Med Phys Fitness 2008;48:259-65.
    • (2008) J Sports Med Phys Fitness , vol.48 , pp. 259-265
    • He, Y.1    Zhang, H.2    Fu, F.3
  • 88
    • 77952947523 scopus 로고    scopus 로고
    • Beneficial effects of exercise training (treadmill) on insulin resistance and nonalcoholic fatty liver disease in high-fat fed C57BL/6 mice
    • Marques CM, Motta VF, Torres TS, Aguila MB, Mandarim-de-Lacerda CA. Beneficial effects of exercise training (treadmill) on insulin resistance and nonalcoholic fatty liver disease in high-fat fed C57BL/6 mice. Braz J Med Biol Res 2010;43:467-75.
    • (2010) Braz J Med Biol Res , vol.43 , pp. 467-475
    • Marques, C.M.1    Motta, V.F.2    Torres, T.S.3    Aguila, M.B.4    Mandarim-de-Lacerda, C.A.5
  • 90
    • 58249085901 scopus 로고    scopus 로고
    • High fat diet induces dysregulation of hepatic oxygen gradients and mitochondrial function in vivo
    • Mantena SK, Vaughn DP, Andringa KK, Eccleston HB, King AL, Abrams GA et al. High fat diet induces dysregulation of hepatic oxygen gradients and mitochondrial function in vivo. Biochem J 2009;417:183-93.
    • (2009) Biochem J , vol.417 , pp. 183-193
    • Mantena, S.K.1    Vaughn, D.P.2    Andringa, K.K.3    Eccleston, H.B.4    King, A.L.5    Abrams, G.A.6
  • 94
    • 37849052672 scopus 로고    scopus 로고
    • Systemic and mitochondrial adaptive responses to moderate exercise in rodents
    • Boveris A, Navarro A. Systemic and mitochondrial adaptive responses to moderate exercise in rodents. Free Radical Biol Med 2008;44:224-9.
    • (2008) Free Radical Biol Med , vol.44 , pp. 224-229
    • Boveris, A.1    Navarro, A.2
  • 95
    • 78650871083 scopus 로고    scopus 로고
    • Acute exercise protects against calcium-induced cardiac mitochondrial permeability transition pore opening in doxorubicin-treated rats
    • Ascensao A, Lumini-Oliveira J, Machado NG, Ferreira RM, Goncalves IO, Moreira AC et al. Acute exercise protects against calcium-induced cardiac mitochondrial permeability transition pore opening in doxorubicin-treated rats. Clin Sci (Lond) 2011;120:37-49.
    • (2011) Clin Sci (Lond) , vol.120 , pp. 37-49
    • Ascensao, A.1    Lumini-Oliveira, J.2    Machado, N.G.3    Ferreira, R.M.4    Goncalves, I.O.5    Moreira, A.C.6
  • 97
    • 77955650026 scopus 로고    scopus 로고
    • Targeting mitochondria: a new promising approach for the treatment of liver diseases
    • Serviddio G, Bellanti F, Sastre J, Vendemiale G, Altomare E. Targeting mitochondria: a new promising approach for the treatment of liver diseases. Curr Med Chem 2010;17:2325-37.
    • (2010) Curr Med Chem , vol.17 , pp. 2325-2337
    • Serviddio, G.1    Bellanti, F.2    Sastre, J.3    Vendemiale, G.4    Altomare, E.5
  • 98
    • 84867249241 scopus 로고    scopus 로고
    • Exercise induces autophagy in peripheral tissues and in the brain
    • He C, Sumpter R Jr, Levine B. Exercise induces autophagy in peripheral tissues and in the brain. Autophagy 2012;8:1548-51.
    • (2012) Autophagy , vol.8 , pp. 1548-1551
    • He, C.1    Sumpter Jr., R.2    Levine, B.3
  • 99
    • 0020410451 scopus 로고
    • Fatty acid oxidation by liver and muscle preparations of exhaustively exercised rats
    • Barakat HA, Kasperek GJ, Dohm GL, Tapscott EB, Snider RD. Fatty acid oxidation by liver and muscle preparations of exhaustively exercised rats. Biochem J 1982;208:419-24.
    • (1982) Biochem J , vol.208 , pp. 419-424
    • Barakat, H.A.1    Kasperek, G.J.2    Dohm, G.L.3    Tapscott, E.B.4    Snider, R.D.5
  • 100
    • 0024073850 scopus 로고
    • Effect of exhaustive exercise on liver mitochondrial function in the rat
    • Bielecki JW, Pawlicka E, Gorski J. Effect of exhaustive exercise on liver mitochondrial function in the rat. Acta Physiol Pol 1988;39:421-6.
    • (1988) Acta Physiol Pol , vol.39 , pp. 421-426
    • Bielecki, J.W.1    Pawlicka, E.2    Gorski, J.3
  • 101
    • 0017135975 scopus 로고
    • Effect of exhaustive swimming on the oxidative phosphorylation and the activity of some enzymes in rat liver mitochondria
    • Radeva-Domustchieva D, Russanov E. Effect of exhaustive swimming on the oxidative phosphorylation and the activity of some enzymes in rat liver mitochondria. Acta Physiol Pharmacol Bulg 1976;2:72-7.
    • (1976) Acta Physiol Pharmacol Bulg , vol.2 , pp. 72-77
    • Radeva-Domustchieva, D.1    Russanov, E.2
  • 102
    • 0033179668 scopus 로고    scopus 로고
    • Effect of exercise duration on characteristics of mitochondrial population from rat liver
    • Venditti P, Masullo P, Meo SD. Effect of exercise duration on characteristics of mitochondrial population from rat liver. Arch Biochem Biophys 1999;368:112-20.
    • (1999) Arch Biochem Biophys , vol.368 , pp. 112-120
    • Venditti, P.1    Masullo, P.2    Meo, S.D.3
  • 103
    • 0020299664 scopus 로고
    • Exercise-induced alterations of hepatic mitochondrial function
    • Tate CA, Wolkowicz PE, McMillin-Wood J. Exercise-induced alterations of hepatic mitochondrial function. Biochem J 1982;208:695-701.
    • (1982) Biochem J , vol.208 , pp. 695-701
    • Tate, C.A.1    Wolkowicz, P.E.2    McMillin-Wood, J.3
  • 104
    • 77449115593 scopus 로고    scopus 로고
    • Endurance exercise causes mitochondrial and oxidative stress in rat liver: effects of a combination of mitochondrial targeting nutrients
    • Sun L, Shen W, Liu Z, Guan S, Liu J, Ding S. Endurance exercise causes mitochondrial and oxidative stress in rat liver: effects of a combination of mitochondrial targeting nutrients. Life Sci 2010;86:39-44.
    • (2010) Life Sci , vol.86 , pp. 39-44
    • Sun, L.1    Shen, W.2    Liu, Z.3    Guan, S.4    Liu, J.5    Ding, S.6
  • 105
    • 0030200558 scopus 로고    scopus 로고
    • Antioxidants, tissue damage, and endurance in trained and untrained young male rats
    • Venditti P, Di Meo S. Antioxidants, tissue damage, and endurance in trained and untrained young male rats. Arch Biochem Biophys 1996;331:63-8.
    • (1996) Arch Biochem Biophys , vol.331 , pp. 63-68
    • Venditti, P.1    Di Meo, S.2
  • 106
    • 0033941013 scopus 로고    scopus 로고
    • Chronically and acutely exercised rats: biomarkers of oxidative stress and endogenous antioxidants
    • Liu J, Yeo HC, Overvik-Douki E, Hagen T, Doniger SJ, Chyu DW et al. Chronically and acutely exercised rats: biomarkers of oxidative stress and endogenous antioxidants. J Appl Physiol 2000;89:21-8.
    • (2000) J Appl Physiol , vol.89 , pp. 21-28
    • Liu, J.1    Yeo, H.C.2    Overvik-Douki, E.3    Hagen, T.4    Doniger, S.J.5    Chyu, D.W.6
  • 107
    • 58649114097 scopus 로고    scopus 로고
    • Cessation of daily wheel running differentially alters fat oxidation capacity in liver, muscle, and adipose tissue
    • Laye MJ, Rector RS, Borengasser SJ, Naples SP, Uptergrove GM, Ibdah JA et al. Cessation of daily wheel running differentially alters fat oxidation capacity in liver, muscle, and adipose tissue. J Appl Physiol 2009;106:161-8.
    • (2009) J Appl Physiol , vol.106 , pp. 161-168
    • Laye, M.J.1    Rector, R.S.2    Borengasser, S.J.3    Naples, S.P.4    Uptergrove, G.M.5    Ibdah, J.A.6
  • 108
    • 51749108218 scopus 로고    scopus 로고
    • Cessation of daily exercise dramatically alters precursors of hepatic steatosis in Otsuka Long-Evans Tokushima Fatty (OLETF) rats
    • Rector RS, Thyfault JP, Laye MJ, Morris RT, Borengasser SJ, Uptergrove GM et al. Cessation of daily exercise dramatically alters precursors of hepatic steatosis in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. J Physiol 2008;586:4241-9.
    • (2008) J Physiol , vol.586 , pp. 4241-4249
    • Rector, R.S.1    Thyfault, J.P.2    Laye, M.J.3    Morris, R.T.4    Borengasser, S.J.5    Uptergrove, G.M.6
  • 109
    • 84885422095 scopus 로고    scopus 로고
    • Habitual physical activity and liver mitochondrial function in patients with non-alcoholic fatty liver disease (NAFLD). A pilot study
    • Gonçalves IO, Portincasa P, Grattagliano I, Pizarro AN, Ascensão A, Magalhães J. Habitual physical activity and liver mitochondrial function in patients with non-alcoholic fatty liver disease (NAFLD). A pilot study. Eur J Clin Invest 2012;42:80.
    • (2012) Eur J Clin Invest , vol.42 , pp. 80
    • Gonçalves, I.O.1    Portincasa, P.2    Grattagliano, I.3    Pizarro, A.N.4    Ascensão, A.5    Magalhães, J.6
  • 110
    • 65249112614 scopus 로고    scopus 로고
    • The muscle-liver axis: does aerobic fitness induce intrahepatic protection against non-alcoholic fatty liver disease?
    • Romijn JA, Pijl H. The muscle-liver axis: does aerobic fitness induce intrahepatic protection against non-alcoholic fatty liver disease? J Physiol 2009;587:1637.
    • (2009) J Physiol , vol.587 , pp. 1637
    • Romijn, J.A.1    Pijl, H.2
  • 111
    • 42249114813 scopus 로고    scopus 로고
    • Health-related fitness and physical activity in patients with nonalcoholic fatty liver disease
    • Krasnoff JB, Painter PL, Wallace JP, Bass NM, Merriman RB. Health-related fitness and physical activity in patients with nonalcoholic fatty liver disease. Hepatology 2008;47:1158-66.
    • (2008) Hepatology , vol.47 , pp. 1158-1166
    • Krasnoff, J.B.1    Painter, P.L.2    Wallace, J.P.3    Bass, N.M.4    Merriman, R.B.5
  • 112
    • 79952361224 scopus 로고    scopus 로고
    • Physical activity recommendations, exercise intensity, and histological severity of nonalcoholic fatty liver disease
    • quiz 9.
    • Kistler KD, Brunt EM, Clark JM, Diehl AM, Sallis JF, Schwimmer JB. Physical activity recommendations, exercise intensity, and histological severity of nonalcoholic fatty liver disease. Am J Gastroenterol 2011;106:460-8; quiz 9.
    • (2011) Am J Gastroenterol , vol.106 , pp. 460-468
    • Kistler, K.D.1    Brunt, E.M.2    Clark, J.M.3    Diehl, A.M.4    Sallis, J.F.5    Schwimmer, J.B.6
  • 113
    • 0014764955 scopus 로고
    • Ultrastructure of rat heart and liver after exhaustive exercise
    • King DW, Gollnick PD. Ultrastructure of rat heart and liver after exhaustive exercise. Am J Physiol 1970;218:1150-5.
    • (1970) Am J Physiol , vol.218 , pp. 1150-1155
    • King, D.W.1    Gollnick, P.D.2
  • 114
    • 0035078629 scopus 로고    scopus 로고
    • The effects of endurance training and exhaustive exercise on mitochondrial enzymes in tissues of the rat (Rattus norvegicus)
    • Terblanche SE, Gohil K, Packer L, Henderson S, Brooks GA. The effects of endurance training and exhaustive exercise on mitochondrial enzymes in tissues of the rat (Rattus norvegicus). Comp Biochem Physiol A Mol Integr Physiol 2001;128:889-96.
    • (2001) Comp Biochem Physiol A Mol Integr Physiol , vol.128 , pp. 889-896
    • Terblanche, S.E.1    Gohil, K.2    Packer, L.3    Henderson, S.4    Brooks, G.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.