메뉴 건너뛰기




Volumn 63, Issue 5, 2014, Pages 607-617

Obesity-associated mechanisms of hepatocarcinogenesis

Author keywords

Adipose tissue remodeling; Hepatocellular carcinoma; Insulin resistance; Lipotoxicity; Nonalcoholic fatty liver disease

Indexed keywords

ADIPOCYTOKINE; INSULIN; SOMATOMEDIN;

EID: 84899447215     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2014.01.011     Document Type: Review
Times cited : (143)

References (152)
  • 2
    • 80051809646 scopus 로고    scopus 로고
    • Impact of obesity on cardiovascular disease
    • K.C. Zalesin, B.A. Franklin, and W.M. Miller et al. Impact of obesity on cardiovascular disease Med Clin North Am 95 5 2011 919 937
    • (2011) Med Clin North Am , vol.95 , Issue.5 , pp. 919-937
    • Zalesin, K.C.1    Franklin, B.A.2    Miller, W.M.3
  • 3
    • 80052245888 scopus 로고    scopus 로고
    • Health and economic burden of the projected obesity trends in the USA and the UK
    • Y.C. Wang, K. McPherson, and T. Marsh et al. Health and economic burden of the projected obesity trends in the USA and the UK Lancet 378 9793 2011 815 825
    • (2011) Lancet , vol.378 , Issue.9793 , pp. 815-825
    • Wang, Y.C.1    McPherson, K.2    Marsh, T.3
  • 4
    • 0037464510 scopus 로고    scopus 로고
    • Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. Adults
    • E.E. Calle, C. Rodriguez, and K. Walker-Thurmond et al. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults N Engl J Med 348 17 2003 1625 1638
    • (2003) N Engl J Med , vol.348 , Issue.17 , pp. 1625-1638
    • Calle, E.E.1    Rodriguez, C.2    Walker-Thurmond, K.3
  • 5
    • 0035146815 scopus 로고    scopus 로고
    • A prospective study of obesity and cancer risk (Sweden)
    • A. Wolk, G. Gridley, and M. Svensson et al. A prospective study of obesity and cancer risk (Sweden) Cancer Causes Control 12 1 2001 13 21
    • (2001) Cancer Causes Control , vol.12 , Issue.1 , pp. 13-21
    • Wolk, A.1    Gridley, G.2    Svensson, M.3
  • 6
    • 0028302476 scopus 로고
    • Obesity and cancer risk: A Danish record-linkage study
    • H. Moller, A. Mellemgaard, and K. Lindvig et al. Obesity and cancer risk: a Danish record-linkage study Eur J Cancer 30A 3 1994 344 350
    • (1994) Eur J Cancer , vol.30 A , Issue.3 , pp. 344-350
    • Moller, H.1    Mellemgaard, A.2    Lindvig, K.3
  • 7
    • 79551510805 scopus 로고    scopus 로고
    • Obesity and cancer risk: Recent review and evidence
    • K. Basen-Engquist, and M. Chang Obesity and cancer risk: recent review and evidence Curr Oncol Rep 13 1 2011 71 76
    • (2011) Curr Oncol Rep , vol.13 , Issue.1 , pp. 71-76
    • Basen-Engquist, K.1    Chang, M.2
  • 8
    • 38949108241 scopus 로고    scopus 로고
    • Body-mass index and incidence of cancer: A systematic review and meta-analysis of prospective observational studies
    • A.G. Renehan, M. Tyson, and M. Egger et al. Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies Lancet 371 9612 2008 569 578
    • (2008) Lancet , vol.371 , Issue.9612 , pp. 569-578
    • Renehan, A.G.1    Tyson, M.2    Egger, M.3
  • 9
    • 33748755434 scopus 로고    scopus 로고
    • Obesity as a risk factor for development and poor prognosis of breast cancer
    • A.R. Carmichael Obesity as a risk factor for development and poor prognosis of breast cancer BJOG 113 10 2006 1160 1166
    • (2006) BJOG , vol.113 , Issue.10 , pp. 1160-1166
    • Carmichael, A.R.1
  • 10
    • 0034331208 scopus 로고    scopus 로고
    • Body mass index and colon cancer mortality in a large prospective study
    • T.K. Murphy, E.E. Calle, and C. Rodriguez et al. Body mass index and colon cancer mortality in a large prospective study Am J Epidemiol 152 9 2000 847 854
    • (2000) Am J Epidemiol , vol.152 , Issue.9 , pp. 847-854
    • Murphy, T.K.1    Calle, E.E.2    Rodriguez, C.3
  • 11
    • 7044229778 scopus 로고    scopus 로고
    • Primary liver cancer: Worldwide incidence and trends
    • F.X. Bosch, J. Ribes, and M. Diaz et al. Primary liver cancer: worldwide incidence and trends Gastroenterology 127 5 Suppl. 1 2004 S5 S16
    • (2004) Gastroenterology , vol.127 , Issue.5 SUPPL. 1
    • Bosch, F.X.1    Ribes, J.2    Diaz, M.3
  • 13
    • 80053088189 scopus 로고    scopus 로고
    • Hepatocellular carcinoma
    • H.B. El-Serag Hepatocellular carcinoma N Engl J Med 365 2011 1118 1127
    • (2011) N Engl J Med , vol.365 , pp. 1118-1127
    • El-Serag, H.B.1
  • 14
    • 84863601615 scopus 로고    scopus 로고
    • Metformin for liver cancer prevention in patients with type 2 diabetes: A systematic review and meta-analysis
    • Z.J. Zhang, Z.J. Zheng, and R. Shi et al. Metformin for liver cancer prevention in patients with type 2 diabetes: a systematic review and meta-analysis J Clin Endocrinol Metab 97 7 2012 2347 2353
    • (2012) J Clin Endocrinol Metab , vol.97 , Issue.7 , pp. 2347-2353
    • Zhang, Z.J.1    Zheng, Z.J.2    Shi, R.3
  • 15
    • 63049133092 scopus 로고    scopus 로고
    • Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005
    • S.F. Altekruse, K.A. McGlynn, and M.E. Reichman Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005 J Clin Oncol 27 9 2009 1485 1491
    • (2009) J Clin Oncol , vol.27 , Issue.9 , pp. 1485-1491
    • Altekruse, S.F.1    McGlynn, K.A.2    Reichman, M.E.3
  • 16
    • 84872613896 scopus 로고    scopus 로고
    • Metabolic syndrome and hepatocellular carcinoma risk
    • F. Turati, R. Talamini, and C. Pelucchi et al. Metabolic syndrome and hepatocellular carcinoma risk Br J Cancer 108 1 2013 222 228
    • (2013) Br J Cancer , vol.108 , Issue.1 , pp. 222-228
    • Turati, F.1    Talamini, R.2    Pelucchi, C.3
  • 17
    • 33746089143 scopus 로고    scopus 로고
    • Relation of body mass index to cancer risk in 362,552 Swedish men
    • C. Samanic, W.H. Chow, and G. Gridley et al. Relation of body mass index to cancer risk in 362,552 Swedish men Cancer Causes Control 17 7 2006 901 909
    • (2006) Cancer Causes Control , vol.17 , Issue.7 , pp. 901-909
    • Samanic, C.1    Chow, W.H.2    Gridley, G.3
  • 18
    • 84860215803 scopus 로고    scopus 로고
    • Metabolic risk factors and primary liver cancer in a prospective study of 578,700 adults
    • W. Borena, S. Strohmaier, and A. Lukanova et al. Metabolic risk factors and primary liver cancer in a prospective study of 578,700 adults Int J Cancer 131 1 2012 193 200
    • (2012) Int J Cancer , vol.131 , Issue.1 , pp. 193-200
    • Borena, W.1    Strohmaier, S.2    Lukanova, A.3
  • 19
    • 84870251301 scopus 로고    scopus 로고
    • Abdominal obesity, weight gain during adulthood and risk of liver and biliary tract cancer in a European cohort
    • S. Schlesinger, K. Aleksandrova, and T. Pischon et al. Abdominal obesity, weight gain during adulthood and risk of liver and biliary tract cancer in a European cohort Int J Cancer 132 3 2013 645 657
    • (2013) Int J Cancer , vol.132 , Issue.3 , pp. 645-657
    • Schlesinger, S.1    Aleksandrova, K.2    Pischon, T.3
  • 20
    • 79960747094 scopus 로고    scopus 로고
    • Metabolic syndrome increases the risk of primary liver cancer in the United States: A study in the SEER-Medicare database
    • T.M. Welzel, B.I. Graubard, and S. Zeuzem et al. Metabolic syndrome increases the risk of primary liver cancer in the United States: a study in the SEER-Medicare database Hepatology 54 2 2011 463 471
    • (2011) Hepatology , vol.54 , Issue.2 , pp. 463-471
    • Welzel, T.M.1    Graubard, B.I.2    Zeuzem, S.3
  • 21
    • 0037129380 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • P. Angulo Nonalcoholic fatty liver disease N Engl J Med 346 16 2002 1221 1231
    • (2002) N Engl J Med , vol.346 , Issue.16 , pp. 1221-1231
    • Angulo, P.1
  • 22
    • 0036894480 scopus 로고    scopus 로고
    • NAFLD may be a common underlying liver disease in patients with hepatocellular carcinoma in the United States
    • J.A. Marrero, R.J. Fontana, and G.L. Su et al. NAFLD may be a common underlying liver disease in patients with hepatocellular carcinoma in the United States Hepatology 36 6 2002 1349 1354
    • (2002) Hepatology , vol.36 , Issue.6 , pp. 1349-1354
    • Marrero, J.A.1    Fontana, R.J.2    Su, G.L.3
  • 23
    • 33750606061 scopus 로고    scopus 로고
    • Long-term follow-up of patients with NAFLD and elevated liver enzymes
    • M. Ekstedt, L.E. Franzen, and U.L. Mathiesen et al. Long-term follow-up of patients with NAFLD and elevated liver enzymes Hepatology 44 4 2006 865 873
    • (2006) Hepatology , vol.44 , Issue.4 , pp. 865-873
    • Ekstedt, M.1    Franzen, L.E.2    Mathiesen, U.L.3
  • 24
    • 70350626532 scopus 로고    scopus 로고
    • Final results of a long-term, clinical follow-up in fatty liver patients
    • S. Dam-Larsen, U. Becker, and M.B. Franzmann et al. Final results of a long-term, clinical follow-up in fatty liver patients Scand J Gastroenterol 44 10 2009 1236 1243
    • (2009) Scand J Gastroenterol , vol.44 , Issue.10 , pp. 1236-1243
    • Dam-Larsen, S.1    Becker, U.2    Franzmann, M.B.3
  • 25
    • 58849134985 scopus 로고    scopus 로고
    • Long-term follow-up of patients with nonalcoholic fatty liver
    • N. Rafiq, C. Bai, and Y. Fang et al. Long-term follow-up of patients with nonalcoholic fatty liver Clin Gastroenterol Hepatol 7 2 2009 234 238
    • (2009) Clin Gastroenterol Hepatol , vol.7 , Issue.2 , pp. 234-238
    • Rafiq, N.1    Bai, C.2    Fang, Y.3
  • 26
    • 0021240022 scopus 로고
    • Liver morphology in morbid obesity: A literature study
    • T. Andersen, and C. Gluud Liver morphology in morbid obesity: a literature study Int J Obes 8 2 1984 97 106
    • (1984) Int J Obes , vol.8 , Issue.2 , pp. 97-106
    • Andersen, T.1    Gluud, C.2
  • 27
    • 0034791598 scopus 로고    scopus 로고
    • The spectrum of liver disease in the general population: Lesson from the Dionysos study
    • S. Bellentani, and C. Tiribelli The spectrum of liver disease in the general population: lesson from the Dionysos study J Hepatol 35 4 2001 531 537
    • (2001) J Hepatol , vol.35 , Issue.4 , pp. 531-537
    • Bellentani, S.1    Tiribelli, C.2
  • 28
    • 10644220306 scopus 로고    scopus 로고
    • Prevalence of hepatic steatosis in an urban population in the United States: Impact of ethnicity
    • J.D. Browning, L.S. Szczepaniak, and R. Dobbins et al. Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity Hepatology 40 6 2004 1387 1395
    • (2004) Hepatology , vol.40 , Issue.6 , pp. 1387-1395
    • Browning, J.D.1    Szczepaniak, L.S.2    Dobbins, R.3
  • 29
    • 65549122652 scopus 로고    scopus 로고
    • Metabolic disturbances in non-alcoholic fatty liver disease
    • C.D. Byrne, R. Olufadi, and K.D. Bruce et al. Metabolic disturbances in non-alcoholic fatty liver disease Clin Sci (Lond) 116 7 2009 539 564
    • (2009) Clin Sci (Lond) , vol.116 , Issue.7 , pp. 539-564
    • Byrne, C.D.1    Olufadi, R.2    Bruce, K.D.3
  • 30
    • 78650486196 scopus 로고    scopus 로고
    • Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: A prospective study
    • C.D. Williams, J. Stengel, and M.I. Asike et al. Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study Gastroenterology 140 1 2011 124 131
    • (2011) Gastroenterology , vol.140 , Issue.1 , pp. 124-131
    • Williams, C.D.1    Stengel, J.2    Asike, M.I.3
  • 31
    • 0033231294 scopus 로고    scopus 로고
    • Association of nonalcoholic fatty liver disease with insulin resistance
    • G. Marchesini, M. Brizi, and A.M. Morselli-Labate et al. Association of nonalcoholic fatty liver disease with insulin resistance Am J Med 107 5 1999 450 455
    • (1999) Am J Med , vol.107 , Issue.5 , pp. 450-455
    • Marchesini, G.1    Brizi, M.2    Morselli-Labate, A.M.3
  • 32
    • 25844508340 scopus 로고    scopus 로고
    • Steatosis and hepatocellular carcinoma risk
    • A. Smedile, and E. Bugianesi Steatosis and hepatocellular carcinoma risk Eur Rev Med Pharmacol Sci 9 5 2005 291 293
    • (2005) Eur Rev Med Pharmacol Sci , vol.9 , Issue.5 , pp. 291-293
    • Smedile, A.1    Bugianesi, E.2
  • 34
    • 84861197159 scopus 로고    scopus 로고
    • Hepatocellular carcinoma in nonalcoholic fatty liver disease: An emerging menace
    • G. Baffy, E.M. Brunt, and S.H. Caldwell Hepatocellular carcinoma in nonalcoholic fatty liver disease: an emerging menace J Hepatol 56 2012 1384 1391
    • (2012) J Hepatol , vol.56 , pp. 1384-1391
    • Baffy, G.1    Brunt, E.M.2    Caldwell, S.H.3
  • 35
    • 84055193440 scopus 로고    scopus 로고
    • Hepatocellular carcinoma in non-alcoholic steatohepatitis: Growing evidence of an epidemic?
    • E. Hashimoto, and K. Tokushige Hepatocellular carcinoma in non-alcoholic steatohepatitis: growing evidence of an epidemic? Hepatol Res 42 1 2012 1 14
    • (2012) Hepatol Res , vol.42 , Issue.1 , pp. 1-14
    • Hashimoto, E.1    Tokushige, K.2
  • 36
    • 33645963121 scopus 로고    scopus 로고
    • Similarities and differences in outcomes of cirrhosis due to nonalcoholic steatohepatitis and hepatitis C
    • A.J. Sanyal, C. Banas, and C. Sargeant et al. Similarities and differences in outcomes of cirrhosis due to nonalcoholic steatohepatitis and hepatitis C Hepatology 43 4 2006 682 689
    • (2006) Hepatology , vol.43 , Issue.4 , pp. 682-689
    • Sanyal, A.J.1    Banas, C.2    Sargeant, C.3
  • 37
    • 77952730428 scopus 로고    scopus 로고
    • The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis
    • M.S. Ascha, I.A. Hanouneh, and R. Lopez et al. The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis Hepatology 51 6 2010 1972 1978
    • (2010) Hepatology , vol.51 , Issue.6 , pp. 1972-1978
    • Ascha, M.S.1    Hanouneh, I.A.2    Lopez, R.3
  • 38
    • 58849132440 scopus 로고    scopus 로고
    • Clinical features and outcomes of cirrhosis due to non-alcoholic steatohepatitis compared with cirrhosis caused by chronic hepatitis C
    • S. Yatsuji, E. Hashimoto, and M. Tobari et al. Clinical features and outcomes of cirrhosis due to non-alcoholic steatohepatitis compared with cirrhosis caused by chronic hepatitis C J Gastroenterol Hepatol 24 2 2009 248 254
    • (2009) J Gastroenterol Hepatol , vol.24 , Issue.2 , pp. 248-254
    • Yatsuji, S.1    Hashimoto, E.2    Tobari, M.3
  • 39
    • 84869436442 scopus 로고    scopus 로고
    • Association between nonalcoholic fatty liver disease and risk for hepatocellular cancer, based on systematic review
    • e2-1359 e2
    • D.L. White, F. Kanwal, and H.B. El-Serag Association between nonalcoholic fatty liver disease and risk for hepatocellular cancer, based on systematic review Clin Gastroenterol Hepatol 10 12 2012 1342 e2 1359 e2
    • (2012) Clin Gastroenterol Hepatol , vol.10 , Issue.12 , pp. 1342
    • White, D.L.1    Kanwal, F.2    El-Serag, H.B.3
  • 40
    • 84863126563 scopus 로고    scopus 로고
    • Difference in malignancies of chronic liver disease due to non-alcoholic fatty liver disease or hepatitis C in Japanese elderly patients
    • Y. Arase, M. Kobayashi, and F. Suzuki et al. Difference in malignancies of chronic liver disease due to non-alcoholic fatty liver disease or hepatitis C in Japanese elderly patients Hepatol Res 42 3 2012 264 272
    • (2012) Hepatol Res , vol.42 , Issue.3 , pp. 264-272
    • Arase, Y.1    Kobayashi, M.2    Suzuki, F.3
  • 41
    • 84856736177 scopus 로고    scopus 로고
    • Large-scale long-term follow-up study of Japanese patients with non-alcoholic Fatty liver disease for the onset of hepatocellular carcinoma
    • Y. Kawamura, Y. Arase, and K. Ikeda et al. Large-scale long-term follow-up study of Japanese patients with non-alcoholic Fatty liver disease for the onset of hepatocellular carcinoma Am J Gastroenterol 107 2 2012 253 261
    • (2012) Am J Gastroenterol , vol.107 , Issue.2 , pp. 253-261
    • Kawamura, Y.1    Arase, Y.2    Ikeda, K.3
  • 42
    • 0030025083 scopus 로고    scopus 로고
    • Hepatocellular carcinoma in cirrhotic and noncirrhotic livers. A clinico-histopathologic study of 804 North American patients
    • U.C. Nzeako, Z.D. Goodman, and K.G. Ishak Hepatocellular carcinoma in cirrhotic and noncirrhotic livers. A clinico-histopathologic study of 804 North American patients Am J Clin Pathol 105 1 1996 65 75
    • (1996) Am J Clin Pathol , vol.105 , Issue.1 , pp. 65-75
    • Nzeako, U.C.1    Goodman, Z.D.2    Ishak, K.G.3
  • 43
    • 34047210411 scopus 로고    scopus 로고
    • TP53 mutations and hepatocellular carcinoma: Insights into the etiology and pathogenesis of liver cancer
    • S.P. Hussain, J. Schwank, and F. Staib et al. TP53 mutations and hepatocellular carcinoma: insights into the etiology and pathogenesis of liver cancer Oncogene 26 15 2007 2166 2176
    • (2007) Oncogene , vol.26 , Issue.15 , pp. 2166-2176
    • Hussain, S.P.1    Schwank, J.2    Staib, F.3
  • 44
    • 0348013131 scopus 로고    scopus 로고
    • Synergistic interaction between aflatoxin B1 and hepatitis B virus in hepatocarcinogenesis
    • M.C. Kew Synergistic interaction between aflatoxin B1 and hepatitis B virus in hepatocarcinogenesis Liver Int 23 6 2003 405 409
    • (2003) Liver Int , vol.23 , Issue.6 , pp. 405-409
    • Kew, M.C.1
  • 45
    • 84945702304 scopus 로고
    • Epidemiology of hepatocellular adenoma. The role of oral contraceptive use
    • J.B. Rooks, H.W. Ory, and K.G. Ishak et al. Epidemiology of hepatocellular adenoma. The role of oral contraceptive use JAMA 242 7 1979 644 648
    • (1979) JAMA , vol.242 , Issue.7 , pp. 644-648
    • Rooks, J.B.1    Ory, H.W.2    Ishak, K.G.3
  • 46
    • 79953012435 scopus 로고    scopus 로고
    • Malignant transformation of hepatocellular adenomas into hepatocellular carcinomas: A systematic review including more than 1600 adenoma cases
    • J.H. Stoot, R.J. Coelen, and M.C. De Jong et al. Malignant transformation of hepatocellular adenomas into hepatocellular carcinomas: a systematic review including more than 1600 adenoma cases HPB (Oxford) 12 8 2010 509 522
    • (2010) HPB (Oxford) , vol.12 , Issue.8 , pp. 509-522
    • Stoot, J.H.1    Coelen, R.J.2    De Jong, M.C.3
  • 47
    • 77049098144 scopus 로고    scopus 로고
    • Hepatitis C prevalence in patients with hepatocellular carcinoma without cirrhosis
    • M.F. Madhoun, J. Fazili, and B.C. Bright et al. Hepatitis C prevalence in patients with hepatocellular carcinoma without cirrhosis Am J Med Sci 339 2 2010 169 173
    • (2010) Am J Med Sci , vol.339 , Issue.2 , pp. 169-173
    • Madhoun, M.F.1    Fazili, J.2    Bright, B.C.3
  • 48
    • 76349089552 scopus 로고    scopus 로고
    • Hepatitis C-associated hepatocellular carcinomas in non-cirrhotic livers
    • M.M. Yeh, H.D. Daniel, and M. Torbenson Hepatitis C-associated hepatocellular carcinomas in non-cirrhotic livers Mod Pathol 23 2 2010 276 283
    • (2010) Mod Pathol , vol.23 , Issue.2 , pp. 276-283
    • Yeh, M.M.1    Daniel, H.D.2    Torbenson, M.3
  • 49
    • 55549106451 scopus 로고    scopus 로고
    • Does nonalcoholic fatty liver disease predispose patients to hepatocellular carcinoma in the absence of cirrhosis?
    • G. Guzman, E.M. Brunt, and L.M. Petrovic et al. Does nonalcoholic fatty liver disease predispose patients to hepatocellular carcinoma in the absence of cirrhosis? Arch Pathol Lab Med 132 11 2008 1761 1766
    • (2008) Arch Pathol Lab Med , vol.132 , Issue.11 , pp. 1761-1766
    • Guzman, G.1    Brunt, E.M.2    Petrovic, L.M.3
  • 50
    • 63349085247 scopus 로고    scopus 로고
    • Hepatocellular carcinomas in patients with metabolic syndrome often develop without significant liver fibrosis: A pathological analysis
    • V. Paradis, S. Zalinski, and E. Chelbi et al. Hepatocellular carcinomas in patients with metabolic syndrome often develop without significant liver fibrosis: a pathological analysis Hepatology 49 3 2009 851 859
    • (2009) Hepatology , vol.49 , Issue.3 , pp. 851-859
    • Paradis, V.1    Zalinski, S.2    Chelbi, E.3
  • 51
    • 71049127867 scopus 로고    scopus 로고
    • Does hepatocellular carcinoma in non-alcoholic steatohepatitis exist in cirrhotic and non-cirrhotic patients?
    • A.L. Chagas, L.O. Kikuchi, and C.P. Oliveira et al. Does hepatocellular carcinoma in non-alcoholic steatohepatitis exist in cirrhotic and non-cirrhotic patients? Braz J Med Biol Res 42 10 2009 958 962
    • (2009) Braz J Med Biol Res , vol.42 , Issue.10 , pp. 958-962
    • Chagas, A.L.1    Kikuchi, L.O.2    Oliveira, C.P.3
  • 52
    • 79953185045 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease progresses to hepatocellular carcinoma in the absence of apparent cirrhosis
    • J. Ertle, A. Dechene, and J.P. Sowa et al. Non-alcoholic fatty liver disease progresses to hepatocellular carcinoma in the absence of apparent cirrhosis Int J Cancer 128 10 2010 2436 2443
    • (2010) Int J Cancer , vol.128 , Issue.10 , pp. 2436-2443
    • Ertle, J.1    Dechene, A.2    Sowa, J.P.3
  • 53
    • 77955625142 scopus 로고    scopus 로고
    • Population-based risk factors and resource utilization for HCC: US perspective
    • A. Sanyal, A. Poklepovic, and E. Moyneur et al. Population-based risk factors and resource utilization for HCC: US perspective Curr Med Res Opin 26 9 2010 2183 2191
    • (2010) Curr Med Res Opin , vol.26 , Issue.9 , pp. 2183-2191
    • Sanyal, A.1    Poklepovic, A.2    Moyneur, E.3
  • 54
    • 84876557053 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease without cirrhosis is an emergent and independent risk factor of hepatocellular carcinoma: A population based study
    • R.N. Rahman, and J.A. Ibdah Nonalcoholic fatty liver disease without cirrhosis is an emergent and independent risk factor of hepatocellular carcinoma: a population based study Hepatology 56 4 (Suppl.) 2012 241A
    • (2012) Hepatology , vol.56 , Issue.4 SUPPL.
    • Rahman, R.N.1    Ibdah, J.A.2
  • 55
    • 0036288123 scopus 로고    scopus 로고
    • Is obesity an independent risk factor for hepatocellular carcinoma in cirrhosis?
    • S. Nair, A. Mason, and J. Eason et al. Is obesity an independent risk factor for hepatocellular carcinoma in cirrhosis? Hepatology 36 1 2002 150 155
    • (2002) Hepatology , vol.36 , Issue.1 , pp. 150-155
    • Nair, S.1    Mason, A.2    Eason, J.3
  • 56
    • 0036829556 scopus 로고    scopus 로고
    • Risk factors for hepatocellular carcinoma: Synergism of alcohol with viral hepatitis and diabetes mellitus
    • M.M. Hassan, L.Y. Hwang, and C.J. Hatten et al. Risk factors for hepatocellular carcinoma: synergism of alcohol with viral hepatitis and diabetes mellitus Hepatology 36 5 2002 1206 1213
    • (2002) Hepatology , vol.36 , Issue.5 , pp. 1206-1213
    • Hassan, M.M.1    Hwang, L.Y.2    Hatten, C.J.3
  • 57
    • 77957774891 scopus 로고    scopus 로고
    • Diabetes enhances hepatocarcinogenesis in noncirrhotic, interferon-treated hepatitis C patients
    • e1-956 e1
    • Y. Kawamura, Y. Arase, and K. Ikeda et al. Diabetes enhances hepatocarcinogenesis in noncirrhotic, interferon-treated hepatitis C patients Am J Med 123 10 2010 951 e1 956 e1
    • (2010) Am J Med , vol.123 , Issue.10 , pp. 951
    • Kawamura, Y.1    Arase, Y.2    Ikeda, K.3
  • 58
    • 84984548367 scopus 로고    scopus 로고
    • Metabolic factors and risk of hepatocellular carcinoma by chronic hepatitis B/C infection: A follow-up study in Taiwan
    • C.L. Chen, H.I. Yang, and W.S. Yang et al. Metabolic factors and risk of hepatocellular carcinoma by chronic hepatitis B/C infection: a follow-up study in Taiwan Gastroenterology 135 1 2008 111 121
    • (2008) Gastroenterology , vol.135 , Issue.1 , pp. 111-121
    • Chen, C.L.1    Yang, H.I.2    Yang, W.S.3
  • 59
    • 33746514438 scopus 로고    scopus 로고
    • Risk factors for hepatocellular carcinoma in patients with alcoholic or viral C cirrhosis
    • G. N'Kontchou, J. Paries, and M.T. Htar et al. Risk factors for hepatocellular carcinoma in patients with alcoholic or viral C cirrhosis Clin Gastroenterol Hepatol 4 8 2006 1062 1068
    • (2006) Clin Gastroenterol Hepatol , vol.4 , Issue.8 , pp. 1062-1068
    • N'Kontchou, G.1    Paries, J.2    Htar, M.T.3
  • 60
    • 0036699940 scopus 로고    scopus 로고
    • Molecular pathogenesis of human hepatocellular carcinoma
    • S.S. Thorgeirsson, and J.W. Grisham Molecular pathogenesis of human hepatocellular carcinoma Nat Genet 31 4 2002 339 346
    • (2002) Nat Genet , vol.31 , Issue.4 , pp. 339-346
    • Thorgeirsson, S.S.1    Grisham, J.W.2
  • 61
    • 33747830764 scopus 로고    scopus 로고
    • Hepatocellular carcinoma pathogenesis: From genes to environment
    • P.A. Farazi, and R.A. DePinho Hepatocellular carcinoma pathogenesis: from genes to environment Nat Rev Cancer 6 9 2006 674 687
    • (2006) Nat Rev Cancer , vol.6 , Issue.9 , pp. 674-687
    • Farazi, P.A.1    Depinho, R.A.2
  • 62
    • 0141648473 scopus 로고    scopus 로고
    • Aberrant CpG island hypermethylation along multistep hepatocarcinogenesis
    • S. Lee, H.J. Lee, and J.H. Kim et al. Aberrant CpG island hypermethylation along multistep hepatocarcinogenesis Am J Pathol 163 4 2003 1371 1378
    • (2003) Am J Pathol , vol.163 , Issue.4 , pp. 1371-1378
    • Lee, S.1    Lee, H.J.2    Kim, J.H.3
  • 63
    • 0033765496 scopus 로고    scopus 로고
    • Genetic instability and aberrant DNA methylation in chronic hepatitis and cirrhosis - A comprehensive study of loss of heterozygosity and microsatellite instability at 39 loci and DNA hypermethylation on 8 CpG islands in microdissected specimens from patients with hepatocellular carcinoma
    • Y. Kondo, Y. Kanai, and M. Sakamoto et al. Genetic instability and aberrant DNA methylation in chronic hepatitis and cirrhosis - a comprehensive study of loss of heterozygosity and microsatellite instability at 39 loci and DNA hypermethylation on 8 CpG islands in microdissected specimens from patients with hepatocellular carcinoma Hepatology 32 5 2000 970 979
    • (2000) Hepatology , vol.32 , Issue.5 , pp. 970-979
    • Kondo, Y.1    Kanai, Y.2    Sakamoto, M.3
  • 64
    • 84873726893 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of hepatocellular carcinoma: An update
    • R.N. Aravalli, E.N. Cressman, and C.J. Steer Cellular and molecular mechanisms of hepatocellular carcinoma: an update Arch Toxicol 87 2 2013 227 247
    • (2013) Arch Toxicol , vol.87 , Issue.2 , pp. 227-247
    • Aravalli, R.N.1    Cressman, E.N.2    Steer, C.J.3
  • 65
    • 84864346121 scopus 로고    scopus 로고
    • Fibrosis-dependent mechanisms of hepatocarcinogenesis
    • D.Y. Zhang, and S.L. Friedman Fibrosis-dependent mechanisms of hepatocarcinogenesis Hepatology 56 2 2012 769 775
    • (2012) Hepatology , vol.56 , Issue.2 , pp. 769-775
    • Zhang, D.Y.1    Friedman, S.L.2
  • 66
    • 78649266473 scopus 로고    scopus 로고
    • Signaling networks in human hepatocarcinogenesis - Novel aspects and therapeutic options
    • K. Breuhahn, and P. Schirmacher Signaling networks in human hepatocarcinogenesis - novel aspects and therapeutic options Prog Mol Biol Transl Sci 97 2010 251 277
    • (2010) Prog Mol Biol Transl Sci , vol.97 , pp. 251-277
    • Breuhahn, K.1    Schirmacher, P.2
  • 67
    • 1542619848 scopus 로고    scopus 로고
    • Cancer as a robust system: Implications for anticancer therapy
    • H. Kitano Cancer as a robust system: implications for anticancer therapy Nat Rev Cancer 4 3 2004 227 235
    • (2004) Nat Rev Cancer , vol.4 , Issue.3 , pp. 227-235
    • Kitano, H.1
  • 68
    • 84857947511 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis and noncirrhotic hepatocellular carcinoma: Fertile soil
    • D.M. Torres, and S.A. Harrison Nonalcoholic steatohepatitis and noncirrhotic hepatocellular carcinoma: fertile soil Semin Liver Dis 32 1 2012 30 38
    • (2012) Semin Liver Dis , vol.32 , Issue.1 , pp. 30-38
    • Torres, D.M.1    Harrison, S.A.2
  • 69
    • 63349106888 scopus 로고    scopus 로고
    • Portal chronic inflammation in nonalcoholic fatty liver disease (NAFLD): A histologic marker of advanced NAFLD-clinicopathologic correlations from the nonalcoholic steatohepatitis clinical research network
    • E.M. Brunt, D.E. Kleiner, and L.A. Wilson et al. Portal chronic inflammation in nonalcoholic fatty liver disease (NAFLD): a histologic marker of advanced NAFLD-clinicopathologic correlations from the nonalcoholic steatohepatitis clinical research network Hepatology 49 3 2009 809 820
    • (2009) Hepatology , vol.49 , Issue.3 , pp. 809-820
    • Brunt, E.M.1    Kleiner, D.E.2    Wilson, L.A.3
  • 70
    • 70349246512 scopus 로고    scopus 로고
    • What's in a NAme?
    • E.M. Brunt What's in a NAme? Hepatology 50 3 2009 663 667
    • (2009) Hepatology , vol.50 , Issue.3 , pp. 663-667
    • Brunt, E.M.1
  • 71
    • 79955663416 scopus 로고    scopus 로고
    • Genetics of alcoholic and nonalcoholic fatty liver disease
    • Q.M. Anstee, A.K. Daly, and C.P. Day Genetics of alcoholic and nonalcoholic fatty liver disease Semin Liver Dis 31 2 2011 128 146
    • (2011) Semin Liver Dis , vol.31 , Issue.2 , pp. 128-146
    • Anstee, Q.M.1    Daly, A.K.2    Day, C.P.3
  • 72
    • 34250020201 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: Epidemiology and molecular carcinogenesis
    • H.B. El-Serag, and K.L. Rudolph Hepatocellular carcinoma: epidemiology and molecular carcinogenesis Gastroenterology 132 7 2007 2557 2576
    • (2007) Gastroenterology , vol.132 , Issue.7 , pp. 2557-2576
    • El-Serag, H.B.1    Rudolph, K.L.2
  • 73
    • 25844457693 scopus 로고    scopus 로고
    • Obesity
    • D.W. Haslam, and W.P. James Obesity Lancet 366 9492 2005 1197 1209
    • (2005) Lancet , vol.366 , Issue.9492 , pp. 1197-1209
    • Haslam, D.W.1    James, W.P.2
  • 74
    • 76049099665 scopus 로고    scopus 로고
    • Adipose tissue expandability, lipotoxicity and the metabolic syndrome - An allostatic perspective
    • S. Virtue, and A. Vidal-Puig Adipose tissue expandability, lipotoxicity and the metabolic syndrome - an allostatic perspective Biochim Biophys Acta 1801 3 2010 338 349
    • (2010) Biochim Biophys Acta , vol.1801 , Issue.3 , pp. 338-349
    • Virtue, S.1    Vidal-Puig, A.2
  • 75
    • 79957916782 scopus 로고    scopus 로고
    • Adipose tissue remodeling and obesity
    • K. Sun, C.M. Kusminski, and P.E. Scherer Adipose tissue remodeling and obesity J Clin Invest 121 6 2011 2094 2101
    • (2011) J Clin Invest , vol.121 , Issue.6 , pp. 2094-2101
    • Sun, K.1    Kusminski, C.M.2    Scherer, P.E.3
  • 76
    • 34247857663 scopus 로고    scopus 로고
    • Obesity, inflammation, and insulin resistance
    • S.E. Shoelson, L. Herrero, and A. Naaz Obesity, inflammation, and insulin resistance Gastroenterology 132 6 2007 2169 2180
    • (2007) Gastroenterology , vol.132 , Issue.6 , pp. 2169-2180
    • Shoelson, S.E.1    Herrero, L.2    Naaz, A.3
  • 77
    • 33845866857 scopus 로고    scopus 로고
    • Inflammation and metabolic disorders
    • G.S. Hotamisligil Inflammation and metabolic disorders Nature 444 7121 2006 860 867
    • (2006) Nature , vol.444 , Issue.7121 , pp. 860-867
    • Hotamisligil, G.S.1
  • 78
    • 79955561312 scopus 로고    scopus 로고
    • Regulation of HIF-1{alpha} activity in adipose tissue by obesity-associated factors: Adipogenesis, insulin, and hypoxia
    • Q. He, Z. Gao, and J. Yin et al. Regulation of HIF-1{alpha} activity in adipose tissue by obesity-associated factors: adipogenesis, insulin, and hypoxia Am J Physiol Endocrinol Metab 300 5 2011 E877 E885
    • (2011) Am J Physiol Endocrinol Metab , vol.300 , Issue.5
    • He, Q.1    Gao, Z.2    Yin, J.3
  • 79
    • 70349238777 scopus 로고    scopus 로고
    • Adipokines in liver diseases
    • F. Marra, and C. Bertolani Adipokines in liver diseases Hepatology 50 3 2009 957 969
    • (2009) Hepatology , vol.50 , Issue.3 , pp. 957-969
    • Marra, F.1    Bertolani, C.2
  • 80
    • 77957200500 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease as a risk factor for hepatocellular carcinoma: Mechanisms and implications
    • F. Stickel, and C. Hellerbrand Non-alcoholic fatty liver disease as a risk factor for hepatocellular carcinoma: mechanisms and implications Gut 59 10 2010 1303 1307
    • (2010) Gut , vol.59 , Issue.10 , pp. 1303-1307
    • Stickel, F.1    Hellerbrand, C.2
  • 81
    • 74549167737 scopus 로고    scopus 로고
    • Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression
    • E.J. Park, J.H. Lee, and G.Y. Yu et al. Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression Cell 140 2 2010 197 208
    • (2010) Cell , vol.140 , Issue.2 , pp. 197-208
    • Park, E.J.1    Lee, J.H.2    Yu, G.Y.3
  • 82
    • 21844468939 scopus 로고    scopus 로고
    • Leptin enhances TNF-alpha production via p38 and JNK MAPK in LPS-stimulated Kupffer cells
    • J. Shen, I. Sakaida, and K. Uchida et al. Leptin enhances TNF-alpha production via p38 and JNK MAPK in LPS-stimulated Kupffer cells Life Sci 77 13 2005 1502 1515
    • (2005) Life Sci , vol.77 , Issue.13 , pp. 1502-1515
    • Shen, J.1    Sakaida, I.2    Uchida, K.3
  • 83
    • 32944478021 scopus 로고    scopus 로고
    • Upregulation of proinflammatory and proangiogenic cytokines by leptin in human hepatic stellate cells
    • S. Aleffi, I. Petrai, and C. Bertolani et al. Upregulation of proinflammatory and proangiogenic cytokines by leptin in human hepatic stellate cells Hepatology 42 6 2005 1339 1348
    • (2005) Hepatology , vol.42 , Issue.6 , pp. 1339-1348
    • Aleffi, S.1    Petrai, I.2    Bertolani, C.3
  • 84
    • 9644265298 scopus 로고    scopus 로고
    • Leptin, insulin resistance, and liver fibrosis in human nonalcoholic fatty liver disease
    • P. Angulo, L.M. Alba, and L.M. Petrovic et al. Leptin, insulin resistance, and liver fibrosis in human nonalcoholic fatty liver disease J Hepatol 41 6 2004 943 949
    • (2004) J Hepatol , vol.41 , Issue.6 , pp. 943-949
    • Angulo, P.1    Alba, L.M.2    Petrovic, L.M.3
  • 85
    • 34047250349 scopus 로고    scopus 로고
    • Concomitant activation of the JAK/STAT, PI3K/AKT, and ERK signaling is involved in leptin-mediated promotion of invasion and migration of hepatocellular carcinoma cells
    • N.K. Saxena, D. Sharma, and X. Ding et al. Concomitant activation of the JAK/STAT, PI3K/AKT, and ERK signaling is involved in leptin-mediated promotion of invasion and migration of hepatocellular carcinoma cells Cancer Res 67 6 2007 2497 2507
    • (2007) Cancer Res , vol.67 , Issue.6 , pp. 2497-2507
    • Saxena, N.K.1    Sharma, D.2    Ding, X.3
  • 86
    • 84866079242 scopus 로고    scopus 로고
    • The role of adiponectin in cancer: A review of current evidence
    • M. Dalamaga, K.N. Diakopoulos, and C.S. Mantzoros The role of adiponectin in cancer: a review of current evidence Endocr Rev 33 4 2012 547 594
    • (2012) Endocr Rev , vol.33 , Issue.4 , pp. 547-594
    • Dalamaga, M.1    Diakopoulos, K.N.2    Mantzoros, C.S.3
  • 87
    • 12844281251 scopus 로고    scopus 로고
    • AMPK, the metabolic syndrome and cancer
    • Z. Luo, A.K. Saha, and X. Xiang et al. AMPK, the metabolic syndrome and cancer Trends Pharmacol Sci 26 2 2005 69 76
    • (2005) Trends Pharmacol Sci , vol.26 , Issue.2 , pp. 69-76
    • Luo, Z.1    Saha, A.K.2    Xiang, X.3
  • 88
    • 33745834319 scopus 로고    scopus 로고
    • Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
    • T. Kadowaki, T. Yamauchi, and N. Kubota et al. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome J Clin Invest 116 7 2006 1784 1792
    • (2006) J Clin Invest , vol.116 , Issue.7 , pp. 1784-1792
    • Kadowaki, T.1    Yamauchi, T.2    Kubota, N.3
  • 89
    • 40549135297 scopus 로고    scopus 로고
    • Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: Lessons from genetically engineered mice
    • C. Postic, and J. Girard Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice J Clin Invest 118 3 2008 829 838
    • (2008) J Clin Invest , vol.118 , Issue.3 , pp. 829-838
    • Postic, C.1    Girard, J.2
  • 90
    • 18244382304 scopus 로고    scopus 로고
    • Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
    • K.L. Donnelly, C.I. Smith, and S.J. Schwarzenberg et al. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease J Clin Invest 115 5 2005 1343 1351
    • (2005) J Clin Invest , vol.115 , Issue.5 , pp. 1343-1351
    • Donnelly, K.L.1    Smith, C.I.2    Schwarzenberg, S.J.3
  • 91
    • 0031887281 scopus 로고    scopus 로고
    • Role of human liver lipogenesis and reesterification in triglycerides secretion and in FFA reesterification
    • F. Diraison, and M. Beylot Role of human liver lipogenesis and reesterification in triglycerides secretion and in FFA reesterification Am J Physiol 274 2 Pt. 1 1998 E321 E327
    • (1998) Am J Physiol , vol.274 , Issue.2 PART 1
    • Diraison, F.1    Beylot, M.2
  • 92
    • 0033636780 scopus 로고    scopus 로고
    • Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice
    • I. Shimomura, M. Matsuda, and R.E. Hammer et al. Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice Mol Cell 6 1 2000 77 86
    • (2000) Mol Cell , vol.6 , Issue.1 , pp. 77-86
    • Shimomura, I.1    Matsuda, M.2    Hammer, R.E.3
  • 93
    • 34347406521 scopus 로고    scopus 로고
    • SREBP-1c transcription factor and lipid homeostasis: Clinical perspective
    • P. Ferre, and F. Foufelle SREBP-1c transcription factor and lipid homeostasis: clinical perspective Horm Res 68 2 2007 72 82
    • (2007) Horm Res , vol.68 , Issue.2 , pp. 72-82
    • Ferre, P.1    Foufelle, F.2
  • 94
    • 84859921736 scopus 로고    scopus 로고
    • A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism
    • M.A. Herman, O.D. Peroni, and J. Villoria et al. A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism Nature 484 7394 2012 333 338
    • (2012) Nature , vol.484 , Issue.7394 , pp. 333-338
    • Herman, M.A.1    Peroni, O.D.2    Villoria, J.3
  • 95
    • 84874600898 scopus 로고    scopus 로고
    • De novo lipogenesis in human fat and liver is linked to ChREBP-beta and metabolic health
    • L. Eissing, T. Scherer, and K. Todter et al. De novo lipogenesis in human fat and liver is linked to ChREBP-beta and metabolic health Nat Commun 4 2013 1528
    • (2013) Nat Commun , vol.4 , pp. 1528
    • Eissing, L.1    Scherer, T.2    Todter, K.3
  • 96
    • 0035979214 scopus 로고    scopus 로고
    • A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver
    • H. Yamashita, M. Takenoshita, and M. Sakurai et al. A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver Proc Natl Acad Sci U S A 98 16 2001 9116 9121
    • (2001) Proc Natl Acad Sci U S A , vol.98 , Issue.16 , pp. 9116-9121
    • Yamashita, H.1    Takenoshita, M.2    Sakurai, M.3
  • 97
    • 0038561165 scopus 로고    scopus 로고
    • Xylulose 5-phosphate mediates glucose-induced lipogenesis by xylulose 5-phosphate-activated protein phosphatase in rat liver
    • T. Kabashima, T. Kawaguchi, and B.E. Wadzinski et al. Xylulose 5-phosphate mediates glucose-induced lipogenesis by xylulose 5-phosphate-activated protein phosphatase in rat liver Proc Natl Acad Sci U S A 100 9 2003 5107 5112
    • (2003) Proc Natl Acad Sci U S A , vol.100 , Issue.9 , pp. 5107-5112
    • Kabashima, T.1    Kawaguchi, T.2    Wadzinski, B.E.3
  • 98
    • 84863012179 scopus 로고    scopus 로고
    • Pharmacological ER stress promotes hepatic lipogenesis and lipid droplet formation
    • J.S. Lee, R. Mendez, and H.H. Heng et al. Pharmacological ER stress promotes hepatic lipogenesis and lipid droplet formation Am J Transl Res 4 1 2012 102 113
    • (2012) Am J Transl Res , vol.4 , Issue.1 , pp. 102-113
    • Lee, J.S.1    Mendez, R.2    Heng, H.H.3
  • 99
    • 76049091112 scopus 로고    scopus 로고
    • Lipid homeostasis, lipotoxicity and the metabolic syndrome
    • R.H. Unger, G.O. Clark, and P.E. Scherer et al. Lipid homeostasis, lipotoxicity and the metabolic syndrome Biochim Biophys Acta 1801 3 2010 209 214
    • (2010) Biochim Biophys Acta , vol.1801 , Issue.3 , pp. 209-214
    • Unger, R.H.1    Clark, G.O.2    Scherer, P.E.3
  • 100
    • 33645156429 scopus 로고    scopus 로고
    • From acute ER stress to physiological roles of the unfolded protein response
    • J. Wu, and R.J. Kaufman From acute ER stress to physiological roles of the unfolded protein response Cell Death Differ 13 3 2006 374 384
    • (2006) Cell Death Differ , vol.13 , Issue.3 , pp. 374-384
    • Wu, J.1    Kaufman, R.J.2
  • 101
    • 38649124615 scopus 로고    scopus 로고
    • Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease
    • P. Puri, F. Mirshahi, and O. Cheung et al. Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease Gastroenterology 134 2 2008 568 576
    • (2008) Gastroenterology , vol.134 , Issue.2 , pp. 568-576
    • Puri, P.1    Mirshahi, F.2    Cheung, O.3
  • 102
    • 77649132053 scopus 로고    scopus 로고
    • Mechanisms and clinical implications of hepatocyte lipoapoptosis
    • S.C. Cazanave, and G.J. Gores Mechanisms and clinical implications of hepatocyte lipoapoptosis Clin Lipidol 5 1 2010 71 85
    • (2010) Clin Lipidol , vol.5 , Issue.1 , pp. 71-85
    • Cazanave, S.C.1    Gores, G.J.2
  • 103
    • 5644231992 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
    • U. Ozcan, Q. Cao, and E. Yilmaz et al. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes Science 306 5695 2004 457 461
    • (2004) Science , vol.306 , Issue.5695 , pp. 457-461
    • Ozcan, U.1    Cao, Q.2    Yilmaz, E.3
  • 104
    • 67349210047 scopus 로고    scopus 로고
    • Unsaturated fatty acids promote hepatoma proliferation and progression through downregulation of the tumor suppressor PTEN
    • M. Vinciguerra, F. Carrozzino, and M. Peyrou et al. Unsaturated fatty acids promote hepatoma proliferation and progression through downregulation of the tumor suppressor PTEN J Hepatol 50 6 2009 1132 1141
    • (2009) J Hepatol , vol.50 , Issue.6 , pp. 1132-1141
    • Vinciguerra, M.1    Carrozzino, F.2    Peyrou, M.3
  • 105
    • 34548746833 scopus 로고    scopus 로고
    • Palmitic acid induces production of proinflammatory cytokine interleukin-8 from hepatocytes
    • S. Joshi-Barve, S.S. Barve, and K. Amancherla et al. Palmitic acid induces production of proinflammatory cytokine interleukin-8 from hepatocytes Hepatology 46 3 2007 823 830
    • (2007) Hepatology , vol.46 , Issue.3 , pp. 823-830
    • Joshi-Barve, S.1    Barve, S.S.2    Amancherla, K.3
  • 107
    • 78650520909 scopus 로고    scopus 로고
    • Lipoexpediency: De novo lipogenesis as a metabolic signal transmitter
    • I.J. Lodhi, X. Wei, and C.F. Semenkovich Lipoexpediency: de novo lipogenesis as a metabolic signal transmitter Trends Endocrinol Metab 22 1 2011 1 8
    • (2011) Trends Endocrinol Metab , vol.22 , Issue.1 , pp. 1-8
    • Lodhi, I.J.1    Wei, X.2    Semenkovich, C.F.3
  • 108
    • 43249092409 scopus 로고    scopus 로고
    • Hepatic triglyceride synthesis and nonalcoholic fatty liver disease
    • S.S. Choi, and A.M. Diehl Hepatic triglyceride synthesis and nonalcoholic fatty liver disease Curr Opin Lipidol 19 3 2008 295 300
    • (2008) Curr Opin Lipidol , vol.19 , Issue.3 , pp. 295-300
    • Choi, S.S.1    Diehl, A.M.2
  • 109
    • 79958828558 scopus 로고    scopus 로고
    • Regulation of lipid droplets by autophagy
    • H. Dong, and M.J. Czaja Regulation of lipid droplets by autophagy Trends Endocrinol Metab 22 6 2011 234 240
    • (2011) Trends Endocrinol Metab , vol.22 , Issue.6 , pp. 234-240
    • Dong, H.1    Czaja, M.J.2
  • 110
    • 65949095803 scopus 로고    scopus 로고
    • Autophagy regulates lipid metabolism
    • R. Singh, S. Kaushik, and Y. Wang et al. Autophagy regulates lipid metabolism Nature 458 7242 2009 1131 1135
    • (2009) Nature , vol.458 , Issue.7242 , pp. 1131-1135
    • Singh, R.1    Kaushik, S.2    Wang, Y.3
  • 111
    • 0035856949 scopus 로고    scopus 로고
    • Insulin signalling and the regulation of glucose and lipid metabolism
    • A.R. Saltiel, and C.R. Kahn Insulin signalling and the regulation of glucose and lipid metabolism Nature 414 6865 2001 799 806
    • (2001) Nature , vol.414 , Issue.6865 , pp. 799-806
    • Saltiel, A.R.1    Kahn, C.R.2
  • 112
    • 3543072186 scopus 로고    scopus 로고
    • Overweight, obesity and cancer: Epidemiological evidence and proposed mechanisms
    • E.E. Calle, and R. Kaaks Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms Nat Rev Cancer 4 8 2004 579 591
    • (2004) Nat Rev Cancer , vol.4 , Issue.8 , pp. 579-591
    • Calle, E.E.1    Kaaks, R.2
  • 113
    • 38649116056 scopus 로고    scopus 로고
    • Selective versus total insulin resistance: A pathogenic paradox
    • M.S. Brown, and J.L. Goldstein Selective versus total insulin resistance: a pathogenic paradox Cell Metab 7 2 2008 95 96
    • (2008) Cell Metab , vol.7 , Issue.2 , pp. 95-96
    • Brown, M.S.1    Goldstein, J.L.2
  • 114
    • 81855225795 scopus 로고    scopus 로고
    • Molecular mechanisms of cancer development in obesity
    • M.J. Khandekar, P. Cohen, and B.M. Spiegelman Molecular mechanisms of cancer development in obesity Nat Rev Cancer 11 12 2011 886 895
    • (2011) Nat Rev Cancer , vol.11 , Issue.12 , pp. 886-895
    • Khandekar, M.J.1    Cohen, P.2    Spiegelman, B.M.3
  • 115
    • 0031974197 scopus 로고    scopus 로고
    • Insulin-like growth factor II induced by hypoxia may contribute to angiogenesis of human hepatocellular carcinoma
    • K.W. Kim, S.K. Bae, and O.H. Lee et al. Insulin-like growth factor II induced by hypoxia may contribute to angiogenesis of human hepatocellular carcinoma Cancer Res 58 2 1998 348 351
    • (1998) Cancer Res , vol.58 , Issue.2 , pp. 348-351
    • Kim, K.W.1    Bae, S.K.2    Lee, O.H.3
  • 116
    • 0030769166 scopus 로고    scopus 로고
    • Biological effects of human insulin receptor substrate-1 overexpression in hepatocytes
    • S. Tanaka, L. Mohr, and E.V. Schmidt et al. Biological effects of human insulin receptor substrate-1 overexpression in hepatocytes Hepatology 26 3 1997 598 604
    • (1997) Hepatology , vol.26 , Issue.3 , pp. 598-604
    • Tanaka, S.1    Mohr, L.2    Schmidt, E.V.3
  • 117
    • 84858776574 scopus 로고    scopus 로고
    • MicroRNAs in metabolism and metabolic disorders
    • V. Rottiers, and A.M. Naar MicroRNAs in metabolism and metabolic disorders Nat Rev Mol Cell Biol 13 4 2012 239 250
    • (2012) Nat Rev Mol Cell Biol , vol.13 , Issue.4 , pp. 239-250
    • Rottiers, V.1    Naar, A.M.2
  • 118
    • 79960523356 scopus 로고    scopus 로고
    • The role of microRNAs in cholesterol efflux and hepatic lipid metabolism
    • K.J. Moore, K.J. Rayner, and Y. Suarez et al. The role of microRNAs in cholesterol efflux and hepatic lipid metabolism Annu Rev Nutr 31 2011 49 63
    • (2011) Annu Rev Nutr , vol.31 , pp. 49-63
    • Moore, K.J.1    Rayner, K.J.2    Suarez, Y.3
  • 119
    • 20444460289 scopus 로고    scopus 로고
    • MicroRNA expression profiles classify human cancers
    • J. Lu, G. Getz, and E.A. Miska et al. MicroRNA expression profiles classify human cancers Nature 435 7043 2005 834 838
    • (2005) Nature , vol.435 , Issue.7043 , pp. 834-838
    • Lu, J.1    Getz, G.2    Miska, E.A.3
  • 120
    • 68949190853 scopus 로고    scopus 로고
    • MicroRNAs involved in tumor suppressor and oncogene pathways: Implications for hepatobiliary neoplasia
    • J.L. Mott MicroRNAs involved in tumor suppressor and oncogene pathways: implications for hepatobiliary neoplasia Hepatology 50 2 2009 630 637
    • (2009) Hepatology , vol.50 , Issue.2 , pp. 630-637
    • Mott, J.L.1
  • 121
    • 78751575782 scopus 로고    scopus 로고
    • The role of microRNAs in liver cancer progression
    • S. Huang, and X. He The role of microRNAs in liver cancer progression Br J Cancer 104 2 2011 235 240
    • (2011) Br J Cancer , vol.104 , Issue.2 , pp. 235-240
    • Huang, S.1    He, X.2
  • 122
    • 84862777528 scopus 로고    scopus 로고
    • MicroRNA profiling of hepatocarcinogenesis identifies C19MC cluster as a novel prognostic biomarker in hepatocellular carcinoma
    • C. Augello, V. Vaira, and L. Caruso et al. MicroRNA profiling of hepatocarcinogenesis identifies C19MC cluster as a novel prognostic biomarker in hepatocellular carcinoma Liver Int 32 5 2012 772 782
    • (2012) Liver Int , vol.32 , Issue.5 , pp. 772-782
    • Augello, C.1    Vaira, V.2    Caruso, L.3
  • 123
    • 84881008193 scopus 로고    scopus 로고
    • Role of miR-122 and lipid metabolism in HCV infection
    • T. Fukuhara, and Y. Matsuura Role of miR-122 and lipid metabolism in HCV infection J Gastroenterol 48 2 2013 169 176
    • (2013) J Gastroenterol , vol.48 , Issue.2 , pp. 169-176
    • Fukuhara, T.1    Matsuura, Y.2
  • 124
    • 58149386462 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis is associated with altered hepatic MicroRNA expression
    • O. Cheung, P. Puri, and C. Eicken et al. Nonalcoholic steatohepatitis is associated with altered hepatic MicroRNA expression Hepatology 48 6 2008 1810 1820
    • (2008) Hepatology , vol.48 , Issue.6 , pp. 1810-1820
    • Cheung, O.1    Puri, P.2    Eicken, C.3
  • 125
    • 84880925312 scopus 로고    scopus 로고
    • Inhibition of p53 attenuates steatosis and liver injury in a mouse model of non-alcoholic fatty liver disease
    • Z. Derdak, K.A. Villegas, and R. Harb et al. Inhibition of p53 attenuates steatosis and liver injury in a mouse model of non-alcoholic fatty liver disease J Hepatol 58 4 2013 785 791
    • (2013) J Hepatol , vol.58 , Issue.4 , pp. 785-791
    • Derdak, Z.1    Villegas, K.A.2    Harb, R.3
  • 126
    • 80052008851 scopus 로고    scopus 로고
    • Circulating microRNAs in patients with chronic hepatitis C and non-alcoholic fatty liver disease
    • S. Cermelli, A. Ruggieri, and J.A. Marrero et al. Circulating microRNAs in patients with chronic hepatitis C and non-alcoholic fatty liver disease PLoS One 6 8 2011 e23937
    • (2011) PLoS One , vol.6 , Issue.8 , pp. 23937
    • Cermelli, S.1    Ruggieri, A.2    Marrero, J.A.3
  • 127
    • 35748961986 scopus 로고    scopus 로고
    • P53 enters the microRNA world
    • H. Hermeking p53 enters the microRNA world Cancer Cell 12 5 2007 414 418
    • (2007) Cancer Cell , vol.12 , Issue.5 , pp. 414-418
    • Hermeking, H.1
  • 128
    • 84880935149 scopus 로고    scopus 로고
    • Mutations in TP53, CTNNB1 and PIK3CA genes in hepatocellular carcinoma associated with hepatitis B and hepatitis C virus infections
    • M.L. Tornesello, L. Buonaguro, and F. Tatangelo et al. Mutations in TP53, CTNNB1 and PIK3CA genes in hepatocellular carcinoma associated with hepatitis B and hepatitis C virus infections Genomics 102 2 2013 74 83
    • (2013) Genomics , vol.102 , Issue.2 , pp. 74-83
    • Tornesello, M.L.1    Buonaguro, L.2    Tatangelo, F.3
  • 129
    • 84861973567 scopus 로고    scopus 로고
    • Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence
    • T. Li, N. Kon, and L. Jiang et al. Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence Cell 149 6 2012 1269 1283
    • (2012) Cell , vol.149 , Issue.6 , pp. 1269-1283
    • Li, T.1    Kon, N.2    Jiang, L.3
  • 130
    • 33745918951 scopus 로고    scopus 로고
    • TIGAR, a p53-inducible regulator of glycolysis and apoptosis
    • K. Bensaad, A. Tsuruta, and M.A. Selak et al. TIGAR, a p53-inducible regulator of glycolysis and apoptosis Cell 126 1 2006 107 120
    • (2006) Cell , vol.126 , Issue.1 , pp. 107-120
    • Bensaad, K.1    Tsuruta, A.2    Selak, M.A.3
  • 131
    • 33745149291 scopus 로고    scopus 로고
    • P53 regulates mitochondrial respiration
    • S. Matoba, J.G. Kang, and W.D. Patino et al. p53 regulates mitochondrial respiration Science 312 5780 2006 1650 1653
    • (2006) Science , vol.312 , Issue.5780 , pp. 1650-1653
    • Matoba, S.1    Kang, J.G.2    Patino, W.D.3
  • 132
    • 78649632422 scopus 로고    scopus 로고
    • Activation of p53 enhances apoptosis and insulin resistance in a rat model of alcoholic liver disease
    • Z. Derdak, C.H. Lang, and K.A. Villegas et al. Activation of p53 enhances apoptosis and insulin resistance in a rat model of alcoholic liver disease J Hepatol 54 1 2011 164 172
    • (2011) J Hepatol , vol.54 , Issue.1 , pp. 164-172
    • Derdak, Z.1    Lang, C.H.2    Villegas, K.A.3
  • 133
    • 0034854091 scopus 로고    scopus 로고
    • Regulation of PTEN transcription by p53
    • V. Stambolic, D. MacPherson, and D. Sas et al. Regulation of PTEN transcription by p53 Mol Cell 8 2 2001 317 325
    • (2001) Mol Cell , vol.8 , Issue.2 , pp. 317-325
    • Stambolic, V.1    Macpherson, D.2    Sas, D.3
  • 135
    • 42949163491 scopus 로고    scopus 로고
    • Mechanisms of hepatic fibrogenesis
    • S.L. Friedman Mechanisms of hepatic fibrogenesis Gastroenterology 134 6 2008 1655 1669
    • (2008) Gastroenterology , vol.134 , Issue.6 , pp. 1655-1669
    • Friedman, S.L.1
  • 136
    • 49749145668 scopus 로고    scopus 로고
    • Senescence of activated stellate cells limits liver fibrosis
    • V. Krizhanovsky, M. Yon, and R.A. Dickins et al. Senescence of activated stellate cells limits liver fibrosis Cell 134 4 2008 657 667
    • (2008) Cell , vol.134 , Issue.4 , pp. 657-667
    • Krizhanovsky, V.1    Yon, M.2    Dickins, R.A.3
  • 137
    • 84876407105 scopus 로고    scopus 로고
    • Roles and mechanisms of cellular senescence in regulation of tissue homeostasis
    • N. Ohtani, and E. Hara Roles and mechanisms of cellular senescence in regulation of tissue homeostasis Cancer Sci 104 5 2013 525 530
    • (2013) Cancer Sci , vol.104 , Issue.5 , pp. 525-530
    • Ohtani, N.1    Hara, E.2
  • 138
    • 84874603171 scopus 로고    scopus 로고
    • Cellular senescence and the senescent secretory phenotype: Therapeutic opportunities
    • T. Tchkonia, Y. Zhu, and J. van Deursen et al. Cellular senescence and the senescent secretory phenotype: therapeutic opportunities J Clin Invest 123 3 2013 966 972
    • (2013) J Clin Invest , vol.123 , Issue.3 , pp. 966-972
    • Tchkonia, T.1    Zhu, Y.2    Van Deursen, J.3
  • 139
    • 84879888338 scopus 로고    scopus 로고
    • Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
    • S. Yoshimoto, T.M. Loo, and K. Atarashi et al. Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome Nature 499 7456 2013 97 101
    • (2013) Nature , vol.499 , Issue.7456 , pp. 97-101
    • Yoshimoto, S.1    Loo, T.M.2    Atarashi, K.3
  • 140
    • 0036135241 scopus 로고    scopus 로고
    • Hepatocellular carcinoma in noncirrhotic liver: CT, clinical, and pathologic findings in 39 U.S. Residents
    • G. Brancatelli, M.P. Federle, and L. Grazioli et al. Hepatocellular carcinoma in noncirrhotic liver: CT, clinical, and pathologic findings in 39 U.S. residents Radiology 222 1 2002 89 94
    • (2002) Radiology , vol.222 , Issue.1 , pp. 89-94
    • Brancatelli, G.1    Federle, M.P.2    Grazioli, L.3
  • 141
    • 0031453502 scopus 로고    scopus 로고
    • Hepatic stellate cell activation in dysplastic nodules: Evidence for an alternate hypothesis concerning human hepatocarcinogenesis
    • Y.N. Park, C.P. Yang, and O. Cubukcu et al. Hepatic stellate cell activation in dysplastic nodules: evidence for an alternate hypothesis concerning human hepatocarcinogenesis Liver 17 6 1997 271 274
    • (1997) Liver , vol.17 , Issue.6 , pp. 271-274
    • Park, Y.N.1    Yang, C.P.2    Cubukcu, O.3
  • 142
    • 35748945421 scopus 로고    scopus 로고
    • Hepatic precancerous lesions and small hepatocellular carcinoma
    • [vii]
    • P. Hytiroglou, Y.N. Park, and G. Krinsky et al. Hepatic precancerous lesions and small hepatocellular carcinoma Gastroenterol Clin North Am 36 4 2007 867 887 [vii]
    • (2007) Gastroenterol Clin North Am , vol.36 , Issue.4 , pp. 867-887
    • Hytiroglou, P.1    Park, Y.N.2    Krinsky, G.3
  • 143
    • 40049097359 scopus 로고    scopus 로고
    • Liver cirrhosis
    • D. Schuppan, and N.H. Afdhal Liver cirrhosis Lancet 371 9615 2008 838 851
    • (2008) Lancet , vol.371 , Issue.9615 , pp. 838-851
    • Schuppan, D.1    Afdhal, N.H.2
  • 144
    • 84882703646 scopus 로고    scopus 로고
    • The gut microbiota and obesity: From correlation to causality
    • L. Zhao The gut microbiota and obesity: from correlation to causality Nat Rev Microbiol 11 9 2013 639 647
    • (2013) Nat Rev Microbiol , vol.11 , Issue.9 , pp. 639-647
    • Zhao, L.1
  • 145
    • 33747040825 scopus 로고    scopus 로고
    • Pattern recognition receptors: A contemporary view on liver diseases
    • G. Szabo, A. Dolganiuc, and P. Mandrekar Pattern recognition receptors: a contemporary view on liver diseases Hepatology 44 2 2006 287 298
    • (2006) Hepatology , vol.44 , Issue.2 , pp. 287-298
    • Szabo, G.1    Dolganiuc, A.2    Mandrekar, P.3
  • 146
    • 21244472975 scopus 로고    scopus 로고
    • IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis
    • S. Maeda, H. Kamata, and J.L. Luo et al. IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis Cell 121 7 2005 977 990
    • (2005) Cell , vol.121 , Issue.7 , pp. 977-990
    • Maeda, S.1    Kamata, H.2    Luo, J.L.3
  • 147
    • 84859812538 scopus 로고    scopus 로고
    • Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4
    • D.H. Dapito, A. Mencin, and G.Y. Gwak et al. Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4 Cancer Cell 21 4 2012 504 516
    • (2012) Cancer Cell , vol.21 , Issue.4 , pp. 504-516
    • Dapito, D.H.1    Mencin, A.2    Gwak, G.Y.3
  • 148
    • 0025260531 scopus 로고
    • Fatty liver hepatitis (steatohepatitis) and obesity: An autopsy study with analysis of risk factors
    • I.R. Wanless, and J.S. Lentz Fatty liver hepatitis (steatohepatitis) and obesity: an autopsy study with analysis of risk factors Hepatology 12 5 1990 1106 1110
    • (1990) Hepatology , vol.12 , Issue.5 , pp. 1106-1110
    • Wanless, I.R.1    Lentz, J.S.2
  • 149
    • 0025002079 scopus 로고
    • Liver pathology in morbidly obese patients with and without diabetes
    • J.F. Silverman, K.F. O'Brien, and S. Long et al. Liver pathology in morbidly obese patients with and without diabetes Am J Gastroenterol 85 10 1990 1349 1355
    • (1990) Am J Gastroenterol , vol.85 , Issue.10 , pp. 1349-1355
    • Silverman, J.F.1    O'Brien, K.F.2    Long, S.3
  • 150
    • 0033038672 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: A spectrum of clinical and pathological severity
    • C.A. Matteoni, Z.M. Younossi, and T. Gramlich et al. Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity Gastroenterology 116 6 1999 1413 1419
    • (1999) Gastroenterology , vol.116 , Issue.6 , pp. 1413-1419
    • Matteoni, C.A.1    Younossi, Z.M.2    Gramlich, T.3
  • 151
    • 0033584440 scopus 로고    scopus 로고
    • The prevalence of hepatitis C virus infection in the United States, 1988 through 1994
    • M.J. Alter, D. Kruszon-Moran, and O.V. Nainan et al. The prevalence of hepatitis C virus infection in the United States, 1988 through 1994 N Engl J Med 341 8 1999 556 562
    • (1999) N Engl J Med , vol.341 , Issue.8 , pp. 556-562
    • Alter, M.J.1    Kruszon-Moran, D.2    Nainan, O.V.3
  • 152
    • 17344370538 scopus 로고    scopus 로고
    • Prognosis of chronic hepatitis C: Results of a large, prospective cohort study
    • C. Niederau, S. Lange, and T. Heintges et al. Prognosis of chronic hepatitis C: results of a large, prospective cohort study Hepatology 28 6 1998 1687 1695
    • (1998) Hepatology , vol.28 , Issue.6 , pp. 1687-1695
    • Niederau, C.1    Lange, S.2    Heintges, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.