Enhanced synthesis of saturated phospholipids is associated with ER stress and lipotoxicity in palmitatetreated hepatic cells

Journal of Lipid Research

Volumn 55, Issue 7, 2014, Pages 1478-1488

  Leamy, Alexandra K ^a   Egnatchik, Robert A ^a   Shiota, Masakazu ^b   Ivanova, Pavlina T ^a   Myers, David S ^c   Brown, H Alex ^a,b,c   Young, Jamey D ^a,b  

^a Department of Chemical and Biomolecular Engineering Department of Molecular Physiology and Biophysics ^*  (United States)

^b VANDERBILT UNIVERSITY   (United States)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Endoplasmic reticulum stress; Lipoapoptosis; Membrane composition; Nonalcoholic fatty liver disease; Phospholipid metabolism; Saturated fatty acids; Triacylglycerol synthesis

Indexed keywords

DIACYLGLYCEROL; DIPALMITOYL PHOSPHATIDIC ACID; LYSOPHOSPHATIDIC ACID; OLEIC ACID; PALMITIC ACID; PHOSPHATIDIC ACID; PHOSPHOLIPID; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; LIPID ANALYSIS; LIPID COMPOSITION; LIPID TRANSPORT; LIPOGENESIS; LIPOTOXICITY; LIVER CELL; MEMBRANE STRUCTURE; METABOLIC REGULATION; NONHUMAN; ORGANELLE SHAPE; PHOSPHOLIPID SYNTHESIS; PRIORITY JOURNAL; RAT; ANIMAL; DRUG EFFECTS; LIVER; METABOLISM; PATHOLOGY; SPRAGUE DAWLEY RAT; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; ENDOPLASMIC RETICULUM STRESS; HEPATOCYTES; LIVER; PALMITIC ACID; PHOSPHOLIPIDS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84904015435     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M050237     Document Type: Article

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