Effect of exercise training on chronic inflammation

Clinica Chimica Acta

Volumn 411, Issue 11-12, 2010, Pages 785-793

  Beavers, Kristen M ^a   Brinkley, Tina E ^a   Nicklas, Barbara J ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Acute phase proteins; Cytokines; Exercise; Inflammation; Physical activity

Indexed keywords

ADIPONECTIN; ALBUMIN; C REACTIVE PROTEIN; FIBRINOGEN; INTERLEUKIN 10; INTERLEUKIN 18; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR 2; BIOLOGICAL MARKER;

AEROBIC EXERCISE; BICYCLE ERGOMETER; CHRONIC INFLAMMATION; ERYTHROCYTE SEDIMENTATION RATE; EXERCISE; FITNESS; HUMAN; LEUKOCYTE COUNT; OBSERVATIONAL STUDY; OXYGEN CONSUMPTION; PHYSICAL ACTIVITY; PRIORITY JOURNAL; REVIEW; RISK FACTOR; TREADMILL EXERCISE; ANIMAL; CHRONIC DISEASE; INFLAMMATION; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL (TOPIC);

ANIMALS; BIOLOGICAL MARKERS; CHRONIC DISEASE; HUMANS; INFLAMMATION; PHYSICAL FITNESS; QUESTIONNAIRES; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 77954192215     PISSN: 00098981     EISSN: 18733492     Source Type: Journal    
DOI: 10.1016/j.cca.2010.02.069     Document Type: Review

References (132)

1. Kolb-Bachofen V. A review on the biological properties of C-reactive protein. Immunobiology 1991, 183:133-145.
2. Gabay C., Kushner I. Acute-phase proteins and other systemic responses to inflammation. N Engl J Med 1999, 340:448-454.
3. Ford E.S., Giles W.H., Myers G.L., Mannino D.M. Population distribution of high-sensitivity C-reactive protein among US men: findings from National Health and Nutrition Examination Survey 1999-2000. Clin Chem 2003, 49:686-690.
4. Ford E.S., Giles W.H., Mokdad A.H., Myers G.L. Distribution and correlates of C-reactive protein concentrations among adult US women. Clin Chem 2004, 50:574-581.
5. Pepys M.B. C-reactive protein fifty years on. Lancet 1981, 1:653-657.
6. Ballou S.P., Kushner I. C-reactive protein and the acute phase response. Adv Intern Med 1992, 37:313-336.
7. Nicklas B.J., You T., Pahor M. Behavioural treatments for chronic systemic inflammation: effects of dietary weight loss and exercise training. CMAJ 2005, 172:1199-1209.
8. Khansari N., Shakiba Y., Mahmoudi M. Chronic inflammation and oxidative stress as a major cause of age-related diseases and cancer. Recent Pat Inflamm Allergy Drug Discov 2009, 3:73-80.
9. Ridker P.M., Cushman M., Stampfer M.J., Tracy R.P., Hennekens C.H. Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N Engl J Med 1997, 336:973-979.
10. Ridker P.M., Rifai N., Pfeffer M.A., et al. Inflammation, pravastatin, and the risk of coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events (CARE) Investigators. Circulation 1998, 98:839-844.
11. Rost N.S., Wolf P.A., Kase C.S., et al. Plasma concentration of C-reactive protein and risk of ischemic stroke and transient ischemic attack: the Framingham study. Stroke 2001, 32:2575-2579.
12. Pradhan A.D., Manson J.E., Rossouw J.E., et al. Inflammatory biomarkers, hormone replacement therapy, and incident coronary heart disease: prospective analysis from the Women's Health Initiative observational study. JAMA 2002, 288:980-987.
13. Pai J.K., Pischon T., Ma J., et al. Inflammatory markers and the risk of coronary heart disease in men and women. N Engl J Med 2004, 351:2599-2610.
14. Ridker P.M. High-sensitivity C-reactive protein, inflammation, and cardiovascular risk: from concept to clinical practice to clinical benefit. Am Heart J 2004, 148:S19-S26.
15. Bansal S., Ridker P.M. Comparison of characteristics of future myocardial infarctions in women with baseline high versus baseline low levels of high-sensitivity C-reactive protein. Am J Cardiol 2007, 99:1500-1503.
16. Strandberg T.E., Tilvis R.S. C-reactive protein, cardiovascular risk factors, and mortality in a prospective study in the elderly. Arterioscler Thromb Vasc Biol 2000, 20:1057-1060.
17. Gussekloo J., Schaap M.C., Frolich M., Blauw G.J., Westendorp R.G. C-reactive protein is a strong but nonspecific risk factor of fatal stroke in elderly persons. Arterioscler Thromb Vasc Biol 2000, 20:1047-1051.
18. Cesari M., Penninx B.W., Newman A.B., et al. Inflammatory markers and onset of cardiovascular events: results from the Health ABC study. Circulation 2003, 108:2317-2322.
19. Tice J.A., Browner W., Tracy R.P., Cummings S.R. The relation of C-reactive protein levels to total and cardiovascular mortality in older U.S. women. Am J Med 2003, 114:199-205.
20. Cao J.J., Thach C., Manolio T.A., et al. C-reactive protein, carotid intima-media thickness, and incidence of ischemic stroke in the elderly: the Cardiovascular Health Study. Circulation 2003, 108:166-170.
21. Kritchevsky S.B., Cesari M., Pahor M. Inflammatory markers and cardiovascular health in older adults. Cardiovasc Res 2005, 66:265-275.
22. Pearson T.A., Mensah G.A., Alexander R.W., et al. Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation 2003, 107:499-511.
23. Yin W.H., Chen J.W., Jen H.L., et al. Independent prognostic value of elevated high-sensitivity C-reactive protein in chronic heart failure. Am Heart J 2004, 147:931-938.
24. Pradhan A.D., Manson J.E., Rifai N., Buring J.E., Ridker P.M. C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA 2001, 286:327-334.
25. Duncan B.B., Schmidt M.I., Pankow J.S., et al. Low-grade systemic inflammation and the development of type 2 diabetes: the atherosclerosis risk in communities study. Diabetes 2003, 52:1799-1805.
26. Duncan B.B., Schmidt M.I. The epidemiology of low-grade chronic systemic inflammation and type 2 diabetes. Diabetes Technol Ther 2006, 8:7-17.
27. Hu F.B., Meigs J.B., Li T.Y., Rifai N., Manson J.E. Inflammatory markers and risk of developing type 2 diabetes in women. Diabetes 2004, 53:693-700.
28. Spector T.D., Hart D.J., Nandra D., et al. Low-level increases in serum C-reactive protein are present in early osteoarthritis of the knee and predict progressive disease. Arthritis Rheum 1997, 40:723-727.
29. Sharif M., Shepstone L., Elson C.J., Dieppe P.A., Kirwan J.R. Increased serum C reactive protein may reflect events that precede radiographic progression in osteoarthritis of the knee. Ann Rheum Dis 2000, 59:71-74.
30. Schmidt R., Schmidt H., Curb J.D., Masaki K., White L.R., Launer L.J. Early inflammation and dementia: a 25-year follow-up of the Honolulu-Asia Aging Study. Ann Neurol 2002, 52:168-174.
31. Kuo H.K., Yen C.J., Chang C.H., Kuo C.K., Chen J.H., Sorond F. Relation of C-reactive protein to stroke, cognitive disorders, and depression in the general population: systematic review and meta-analysis. Lancet Neurol 2005, 4:371-380.
32. Penninx B.W., Kritchevsky S.B., Newman A.B., et al. Inflammatory markers and incident mobility limitation in the elderly. J Am Geriatr Soc 2004, 52:1105-1113.
33. Streetz K.L., Wustefeld T., Klein C., Manns M.P., Trautwein C. Mediators of inflammation and acute phase response in the liver. Cell Mol Biol (Noisy -le-grand) 2001, 47:661-673.
34. Heinrich P.C., Castell J.V., Andus T. Interleukin-6 and the acute phase response. Biochem J 1990, 265:621-636.
35. Koukkunen H., Penttila K., Kemppainen A., et al. C-reactive protein, fibrinogen, interleukin-6 and tumour necrosis factor-alpha in the prognostic classification of unstable angina pectoris. Ann Med 2001, 33:37-47.
36. Vasan R.S., Sullivan L.M., Roubenoff R., et al. Inflammatory markers and risk of heart failure in elderly subjects without prior myocardial infarction: the Framingham Heart Study. Circulation 2003, 107:1486-1491.
37. Stark J.R., Li H., Kraft P., et al. Circulating prediagnostic interleukin-6 and C-reactive protein and prostate cancer incidence and mortality. Int J Cancer 2009, 124:2683-2689.
38. Ferrucci L., Harris T.B., Guralnik J.M., et al. Serum IL-6 level and the development of disability in older persons. J Am Geriatr Soc 1999, 47:639-646.
39. Blankenberg S., Luc G., Ducimetiere P., et al. Interleukin-18 and the risk of coronary heart disease in European men: the Prospective Epidemiological Study of Myocardial Infarction (PRIME). Circulation 2003, 108:2453-2459.
40. Espinola-Klein C., Rupprecht H.J., Bickel C., et al. Impact of inflammatory markers on cardiovascular mortality in patients with metabolic syndrome. Eur J Cardiovasc Prev Rehabil 2008, 15:278-284.
41. Everett B.M., Bansal S., Rifai N., Buring J.E., Ridker P.M. Interleukin-18 and the risk of future cardiovascular disease among initially healthy women. Atherosclerosis 2009, 202:282-288.
42. Gokkusu C., Aydin M., Ozkok E., et al. Influences of genetic variants in interleukin-15 gene and serum interleukin-15 levels on coronary heart disease. Cytokine 2009.
43. Hivert M.F., Sun Q., Shrader P., Mantzoros C.S., Meigs J.B., Hu F.B. Circulating IL-18 and the risk of type 2 diabetes in women. Diabetologia 2009, 52:2101-2108.
44. Caruso D.J., Carmack A.J., Lokeshwar V.B., Duncan R.C., Soloway M.S., Lokeshwar B.L. Osteopontin and interleukin-8 expression is independently associated with prostate cancer recurrence. Clin Cancer Res 2008, 14:4111-4118.
45. Tziakas D.N., Chalikias G.K., Kaski J.C., et al. Inflammatory and anti-inflammatory variable clusters and risk prediction in acute coronary syndrome patients: a factor analysis approach. Atherosclerosis 2007, 193:196-203.
46. The endocrine response to acute illness 1999, Karger.
47. Mitch W.E., Goldberg A.L. Mechanisms of muscle wasting. The role of the ubiquitin-proteasome pathway. N Engl J Med 1996, 335:1897-1905.
48. Aris R.M., Lester G.E., Ontjes D.A. Bone loss physiology in critically ill patients. Chest 1998, 114:954-955.
49. Smith L.M., Cuthbertson B., Harvie J., Webster N., Robins S., Ralston S.H. Increased bone resorption in the critically ill: association with sepsis and increased nitric oxide production. Crit Care Med 2002, 30:837-840.
50. Marik P.E. Dyslipidemia in the critically ill. Crit Care Clin 2006, 22:151-159. viii.
51. Wilund K.R. Is the anti-inflammatory effect of regular exercise responsible for reduced cardiovascular disease?. Clin Sci (Lond) 2007, 112:543-555.
52. Mathur N., Pedersen B.K. Exercise as a mean to control low-grade systemic inflammation. Mediators Inflamm 2008, 2008:109502.
53. Lira F.S., Rosa J.C., Zanchi N.E., et al. Regulation of inflammation in the adipose tissue in cancer cachexia: effect of exercise. Cell Biochem Funct 2009, 27:71-75.
54. Nader G.A., Lundberg I.E. Exercise as an anti-inflammatory intervention to combat inflammatory diseases of muscle. Curr Opin Rheumatol 2009.
55. Alexanderson H. Exercise effects in patients with adult idiopathic inflammatory myopathies. Curr Opin Rheumatol 2009, 21:158-163.
56. van d V., Janssen T.W. The potential anti-inflammatory effect of exercise in chronic obstructive pulmonary disease. Respiration 2010, 79:160-174.
57. Lundberg I.E., Nader G.A. Molecular effects of exercise in patients with inflammatory rheumatic disease. Nat Clin Pract Rheumatol 2008, 4:597-604.
58. Sanders A.E., Slade G.D., Fitzsimmons T.R., Bartold P.M. Physical activity, inflammatory biomarkers in gingival crevicular fluid and periodontitis. J Clin Periodontol 2009, 36:388-395.
59. Ayan C., Martin V. Systemic lupus erythematosus and exercise. Lupus 2007, 16:5-9.
60. White L.J., Castellano V. Exercise and brain health-implications for multiple sclerosis: Part II-immune factors and stress hormones. Sports Med 2008, 38:179-186.
61. Hsu F.C., Kritchevsky S.B., Liu Y., et al. Association between inflammatory components and physical function in the health, aging, and body composition study: a principal component analysis approach. J Gerontol A Biol Sci Med Sci 2009, 64:581-589.
62. Taaffe D.R., Harris T.B., Ferrucci L., Rowe J., Seeman T.E. Cross-sectional and prospective relationships of interleukin-6 and C-reactive protein with physical performance in elderly persons: MacArthur studies of successful aging. J Gerontol A Biol Sci Med Sci 2000, 55:M709-M715.
63. Geffken D.F., Cushman M., Burke G.L., Polak J.F., Sakkinen P.A., Tracy R.P. Association between physical activity and markers of inflammation in a healthy elderly population. Am J Epidemiol 2001, 153:242-250.
64. Wannamethee S.G., Lowe G.D., Whincup P.H., Rumley A., Walker M., Lennon L. Physical activity and hemostatic and inflammatory variables in elderly men. Circulation 2002, 105:1785-1790.
65. Ford E.S. Does exercise reduce inflammation? Physical activity and C-reactive protein among U.S. adults. Epidemiology 2002, 13:561-568.
66. Abramson J.L., Vaccarino V. Relationship between physical activity and inflammation among apparently healthy middle-aged and older US adults. Arch Intern Med 2002, 162:1286-1292.
67. Pischon T., Hankinson S.E., Hotamisligil G.S., Rifai N., Rimm E.B. Leisure-time physical activity and reduced plasma levels of obesity-related inflammatory markers. Obes Res 2003, 11:1055-1064.
68. King D.E., Carek P., Mainous A.G., Pearson W.S. Inflammatory markers and exercise: differences related to exercise type. Med Sci Sports Exerc 2003, 35:575-581.
69. Reuben D.B., Judd-Hamilton L., Harris T.B., Seeman T.E. The associations between physical activity and inflammatory markers in high-functioning older persons: MacArthur Studies of Successful Aging. J Am Geriatr Soc 2003, 51:1125-1130.
70. Colbert L.H., Visser M., Simonsick E.M., et al. Physical activity, exercise, and inflammatory markers in older adults: findings from the Health, Aging and Body Composition Study. J Am Geriatr Soc 2004, 52:1098-1104.
71. Verdaet D., Dendale P., De B.D., Delanghe J., Block P., De B.G. Association between leisure time physical activity and markers of chronic inflammation related to coronary heart disease. Atherosclerosis 2004, 176:303-310.
72. Albert M.A., Glynn R.J., Ridker P.M. Effect of physical activity on serum C-reactive protein. Am J Cardiol 2004, 93:221-225.
73. Elosua R., Bartali B., Ordovas J.M., Corsi A.M., Lauretani F., Ferrucci L. Association between physical activity, physical performance, and inflammatory biomarkers in an elderly population: the InCHIANTI study. J Gerontol A Biol Sci Med Sci 2005, 60:760-767.
74. Pitsavos C., Panagiotakos D.B., Chrysohoou C., Kavouras S., Stefanadis C. The associations between physical activity, inflammation, and coagulation markers, in people with metabolic syndrome: the ATTICA study. Eur J Cardiovasc Prev Rehabil 2005, 12:151-158.
75. Borodulin K., Laatikainen T., Salomaa V., Jousilahti P. Associations of leisure time physical activity, self-rated physical fitness, and estimated aerobic fitness with serum C-reactive protein among 3, 803 adults. Atherosclerosis 2006, 185:381-387.
76. Hjelstuen A., Anderssen S.A., Holme I., Seljeflot I., Klemsdal T.O. Markers of inflammation are inversely related to physical activity and fitness in sedentary men with treated hypertension. Am J Hypertens 2006, 19:669-675.
77. Nazmi A., Oliveira I.O., Victora C.G. Correlates of C-reactive protein levels in young adults: a population-based cohort study of 3827 subjects in Brazil. Braz J Med Biol Res 2008, 41:357-367.
78. Majka D.S., Chang R.W., Vu T.H., et al. Physical activity and high-sensitivity C-reactive protein: the multi-ethnic study of atherosclerosis. Am J Prev Med 2009, 36:56-62.
79. Autenrieth C., Schneider A., Doring A., et al. Association between different domains of physical activity and markers of inflammation. Med Sci Sports Exerc 2009, 41:1706-1713.
80. Yu Z., Ye X., Wang J., et al. Associations of physical activity with inflammatory factors, adipocytokines, and metabolic syndrome in middle-aged and older chinese people. Circulation 2009, 119:2969-2977.
81. Church T.S., Barlow C.E., Earnest C.P., Kampert J.B., Priest E.L., Blair S.N. Associations between cardiorespiratory fitness and C-reactive protein in men. Arterioscler Thromb Vasc Biol 2002, 22:1869-1876.
82. Aronson D., Sella R., Sheikh-Ahmad M., et al. The association between cardiorespiratory fitness and C-reactive protein in subjects with the metabolic syndrome. J Am Coll Cardiol 2004, 44:2003-2007.
83. Rahimi K., Secknus M.A., Adam M., et al. Correlation of exercise capacity with high-sensitive C-reactive protein in patients with stable coronary artery disease. Am Heart J 2005, 150:1282-1289.
84. Kullo I.J., Khaleghi M., Hensrud D.D. Markers of inflammation are inversely associated with VO2 max in asymptomatic men. J Appl Physiol 2007, 102:1374-1379.
85. Jae S.Y., Heffernan K.S., Lee M.K., Fernhall B., Park W.H. Relation of cardiorespiratory fitness to inflammatory markers, fibrinolytic factors, and lipoprotein(a) in patients with type 2 diabetes mellitus. Am J Cardiol 2008, 102:700-703.
86. Giallauria F., Palomba S., De S.I., et al. Inflammatory markers and visceral fat are inversely associated with maximal oxygen consumption in women with polycystic ovary syndrome (PCOS). Clin Endocrinol (Oxf) 2009, 70:394-400.
87. Arsenault B.J., Cartier A., Cote M., et al. Body composition, cardiorespiratory fitness, and low-grade inflammation in middle-aged men and women. Am J Cardiol 2009, 104:240-246.
88. Dekker M.J., Lee S., Hudson R., et al. An exercise intervention without weight loss decreases circulating interleukin-6 in lean and obese men with and without type 2 diabetes mellitus. Metabolism 2007, 56:332-338.
89. Zoppini G., Targher G., Zamboni C., et al. Effects of moderate-intensity exercise training on plasma biomarkers of inflammation and endothelial dysfunction in older patients with type 2 diabetes. Nutr Metab Cardiovasc Dis 2006, 16:543-549.
90. Marcell T.J., McAuley K.A., Traustadottir T., Reaven P.D. Exercise training is not associated with improved levels of C-reactive protein or adiponectin. Metabolism 2005, 54:533-541.
91. Fairey A.S., Courneya K.S., Field C.J., et al. Effect of exercise training on C-reactive protein in postmenopausal breast cancer survivors: a randomized controlled trial. Brain Behav Immun 2005, 19:381-388.
92. Hammett C.J., Oxenham H.C., Baldi J.C., et al. Effect of six months' exercise training on C-reactive protein levels in healthy elderly subjects. J Am Coll Cardiol 2004, 44:2411-2413.
93. Nicklas B.J., Ambrosius W., Messier S.P., et al. Diet-induced weight loss, exercise, and chronic inflammation in older, obese adults: a randomized controlled clinical trial. Am J Clin Nutr 2004, 79:544-551.
94. Rauramaa R., Halonen P., Vaisanen S.B., et al. Effects of aerobic physical exercise on inflammation and atherosclerosis in men: the DNASCO Study: a six-year randomized, controlled trial. Ann Intern Med 2004, 140:1007-1014.
95. Campbell K.L., Campbell P.T., Ulrich C.M., et al. No reduction in C-reactive protein following a 12-month randomized controlled trial of exercise in men and women. Cancer Epidemiol Biomarkers Prev 2008, 17:1714-1718.
96. Kelley G.A., Kelley K.S. Effects of aerobic exercise on C-reactive protein, body composition, and maximum oxygen consumption in adults: a meta-analysis of randomized controlled trials. Metabolism 2006, 55:1500-1507.
97. Milani R.V., Lavie C.J., Mehra M.R. Reduction in C-reactive protein through cardiac rehabilitation and exercise training. J Am Coll Cardiol 2004, 43:1056-1061.
98. Okita K., Nishijima H., Murakami T., et al. Can exercise training with weight loss lower serum C-reactive protein levels?. Arterioscler Thromb Vasc Biol 2004, 24:1868-1873.
99. Obisesan T.O., Leeuwenburgh C., Phillips T., et al. C-reactive protein genotypes affect baseline, but not exercise training-induced changes, in C-reactive protein levels. Arterioscler Thromb Vasc Biol 2004, 24:1874-1879.
100. Oberbach A., Tonjes A., Kloting N., et al. Effect of a 4week physical training program on plasma concentrations of inflammatory markers in patients with abnormal glucose tolerance. Eur J Endocrinol 2006, 154:577-585.
101. Giannopoulou I., Fernhall B., Carhart R., et al. Effects of diet and/or exercise on the adipocytokine and inflammatory cytokine levels of postmenopausal women with type 2 diabetes. Metabolism 2005, 54:866-875.
102. Campbell P.T., Campbell K.L., Wener M.H., et al. A yearlong exercise intervention decreases CRP among obese postmenopausal women. Med Sci Sports Exerc 2009, 41:1533-1539.
103. Kadoglou N.P., Iliadis F., Angelopoulou N., et al. The anti-inflammatory effects of exercise training in patients with type 2 diabetes mellitus. Eur J Cardiovasc Prev Rehabil 2007, 14:837-843.
104. Goldhammer E., Tanchilevitch A., Maor I., Beniamini Y., Rosenschein U., Sagiv M. Exercise training modulates cytokines activity in coronary heart disease patients. Int J Cardiol 2005, 100:93-99.
105. Larsen A.I., Aukrust P., Aarsland T., Dickstein K. Effect of aerobic exercise training on plasma levels of tumor necrosis factor alpha in patients with heart failure. Am J Cardiol 2001, 88:805-808.
106. Conraads V.M., Beckers P., Bosmans J., et al. Combined endurance/resistance training reduces plasma TNF-alpha receptor levels in patients with chronic heart failure and coronary artery disease. Eur Heart J 2002, 23:1854-1860.
107. Troseid M., Lappegard K.T., Mollnes T.E., Arnesen H., Seljeflot I. The effect of exercise on serum levels of interleukin-18 and components of the metabolic syndrome. Metab Syndr Relat Disord 2009.
108. Lakka T.A., Lakka H.M., Rankinen T., et al. Effect of exercise training on plasma levels of C-reactive protein in healthy adults: the HERITAGE Family Study. Eur Heart J 2005, 26:2018-2025.
109. Tisi P.V., Hulse M., Chulakadabba A., Gosling P., Shearman C.P. Exercise training for intermittent claudication: does it adversely affect biochemical markers of the exercise-induced inflammatory response?. Eur J Vasc Endovasc Surg 1997, 14:344-350.
110. Nicklas B.J., Hsu F.C., Brinkley T.J., et al. Exercise training and plasma C-reactive protein and interleukin-6 in elderly people. J Am Geriatr Soc 2008, 56:2045-2052.
111. Nawaz S., Walker R.D., Wilkinson C.H., Saxton J.M., Pockley A.G., Wood R.F. The inflammatory response to upper and lower limb exercise and the effects of exercise training in patients with claudication. J Vasc Surg 2001, 33:392-399.
112. Kohut M.L., McCann D.A., Russell D.W., et al. Aerobic exercise, but not flexibility/resistance exercise, reduces serum IL-18, CRP, and IL-6 independent of beta-blockers, BMI, and psychosocial factors in older adults. Brain Behav Immun 2006, 20:201-209.
113. Walther C., Mobius-Winkler S., Linke A., et al. Regular exercise training compared with percutaneous intervention leads to a reduction of inflammatory markers and cardiovascular events in patients with coronary artery disease. Eur J Cardiovasc Prev Rehabil 2008, 15:107-112.
114. Beavers, K. M., Hsu, F. C., Isom, S., Kritchevsky, S. B., Church, T., Goodpaster, B. H., Pahor, M., and Nicklas, B. J. Long-term physical activity and inflammatory biomarkers in older adults. Unpublished manuscript.
115. Rall L.C., Roubenoff R., Cannon J.G., Abad L.W., Dinarello C.A., Meydani S.N. Effects of progressive resistance training on immune response in aging and chronic inflammation. Med Sci Sports Exerc 1996, 28:1356-1365.
116. Brooks N., Layne J.E., Gordon P.L., Roubenoff R., Nelson M.E., Castaneda-Sceppa C. Strength training improves muscle quality and insulin sensitivity in Hispanic older adults with type 2 diabetes. Int J Med Sci 2007, 4:19-27.
117. McFarlin B.K., Flynn M.G., Campbell W.W., Stewart L.K., Timmerman K.L. TLR4 is lower in resistance-trained older women and related to inflammatory cytokines. Med Sci Sports Exerc 2004, 36:1876-1883.
118. Levinger I., Goodman C., Peake J., et al. Inflammation, hepatic enzymes and resistance training in individuals with metabolic risk factors. Diabet Med 2009, 26:220-227.
119. Brochu M., Malita M.F., Messier V., et al. Resistance training does not contribute to improving the metabolic profile after a 6-month weight loss program in overweight and obese postmenopausal women. J Clin Endocrinol Metab 2009, 94:3226-3233.
120. Smith J.K., Dykes R., Douglas J.E., Krishnaswamy G., Berk S. Long-term exercise and atherogenic activity of blood mononuclear cells in persons at risk of developing ischemic heart disease. JAMA 1999, 281:1722-1727.
121. Timmerman K.L., Flynn M.G., Coen P.M., Markofski M.M., Pence B.D. Exercise training-induced lowering of inflammatory (CD14+CD16+) monocytes: a role in the anti-inflammatory influence of exercise?. J Leukoc Biol 2008, 84:1271-1278.
122. Stewart L.K., Flynn M.G., Campbell W.W., et al. Influence of exercise training and age on CD14+ cell-surface expression of toll-like receptor 2 and 4. Brain Behav Immun 2005, 19:389-397.
123. McFarlin B.K., Flynn M.G., Campbell W.W., et al. Physical activity status, but not age, influences inflammatory biomarkers and toll-like receptor 4. J Gerontol A Biol Sci Med Sci 2006, 61:388-393.
124. Gleeson M., McFarlin B., Flynn M. Exercise and toll-like receptors. Exerc Immunol Rev 2006, 12:34-53.
125. Sloan R.P., Shapiro P.A., Demeersman R.E., et al. Aerobic exercise attenuates inducible TNF production in humans. J Appl Physiol 2007, 103:1007-1011.
126. Febbraio M.A., Pedersen B.K. Muscle-derived interleukin-6: mechanisms for activation and possible biological roles. FASEB J 2002, 16:1335-1347.
127. Pedersen M., Bruunsgaard H., Weis N., et al. Circulating levels of TNF-alpha and IL-6-relation to truncal fat mass and muscle mass in healthy elderly individuals and in patients with type-2 diabetes. Mech Ageing Dev 2003, 124:495-502.
128. Starkie R., Ostrowski S.R., Jauffred S., Febbraio M., Pedersen B.K. Exercise and IL-6 infusion inhibit endotoxin-induced TNF-alpha production in humans. FASEB J 2003, 17:884-886.
129. Akerstrom T., Steensberg A., Keller P., Keller C., Penkowa M., Pedersen B.K. Exercise induces interleukin-8 expression in human skeletal muscle. J Physiol 2005, 563:507-516.
130. Scheele C., Nielsen S., Pedersen B.K. ROS and myokines promote muscle adaptation to exercise. Trends Endocrinol Metab 2009, 20:95-99.
131. Brooks S.V., Vasilaki A., Larkin L.M., McArdle A., Jackson M.J. Repeated bouts of aerobic exercise lead to reductions in skeletal muscle free radical generation and nuclear factor kappaB activation. J Physiol 2008, 586:3979-3990.
132. Gielen S., Adams V., Mobius-Winkler S., et al. Anti-inflammatory effects of exercise training in the skeletal muscle of patients with chronic heart failure. J Am Coll Cardiol 2003, 42:861-868.