메뉴 건너뛰기




Volumn 15, Issue 5, 2014, Pages 7352-7379

Molecular mechanisms and new treatment strategies for non-alcoholic steatohepatitis (NASH)

Author keywords

Microbiome; Non alcoholic fatty liver; Non alcoholic steatohepatitis; Oxidative stress

Indexed keywords

ADIPOCYTOKINE; ADIPORON; ALPHA TOCOPHEROL; ANTIDIABETIC AGENT; CARNITINE; CETILISTAT; DIPEPTIDYL PEPTIDASE IV INHIBITOR; EZETIMIBE; HYDROGEN; LYCOPENE; METFORMIN; PENTOXIFYLLINE; PIOGLITAZONE; TETRAHYDROLIPSTATIN; UNCLASSIFIED DRUG; URSODEOXYCHOLIC ACID; ADIPONECTIN RECEPTOR; ANTIOBESITY AGENT; ANTIOXIDANT;

EID: 84899764290     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms15057352     Document Type: Review
Times cited : (111)

References (139)
  • 3
    • 63349106888 scopus 로고    scopus 로고
    • Portal chronic inflammation in nonalcoholic fatty liver disease (NAFLD): A histologic marker of advanced NAFLD-Clinicopathologic correlations from the nonalcoholic steatohepatitis clinical research network
    • Brunt, E. M.; Kleiner, D. E.; Wilson, L. A.; Unalp, A.; Behling, C. E.; Lavine, J. E.; Neuschwander-Tetri, B. A. Portal chronic inflammation in nonalcoholic fatty liver disease (NAFLD): A histologic marker of advanced NAFLD-Clinicopathologic correlations from the nonalcoholic steatohepatitis clinical research network. Hepatology 2009, 49, 809-820.
    • (2009) Hepatology , vol.49 , pp. 809-820
    • Brunt, E.M.1    Kleiner, D.E.2    Wilson, L.A.3    Unalp, A.4    Behling, C.E.5    Lavine, J.E.6    Neuschwander-Tetri, B.A.7
  • 4
    • 58849132440 scopus 로고    scopus 로고
    • Clinical features and outcomes of cirrhosis due to non-alcoholic steatohepatitis compared with cirrhosis caused by chronic hepatitis C
    • Yatsuji, S.; Hashimoto, E.; Tobari, M.; Taniai, M.; Tokushige, K.; Shiratori, K. Clinical features and outcomes of cirrhosis due to non-alcoholic steatohepatitis compared with cirrhosis caused by chronic hepatitis C. J. Gastroenterol. Hepatol. 2009, 24, 248-254.
    • (2009) J. Gastroenterol. Hepatol , vol.24 , pp. 248-254
    • Yatsuji, S.1    Hashimoto, E.2    Tobari, M.3    Taniai, M.4    Tokushige, K.5    Shiratori, K.6
  • 6
    • 4644297019 scopus 로고    scopus 로고
    • Natural history of nonalcoholic steatohepatitis: A longitudinal study of repeat liver biopsies
    • Fassio, E.; Alvarez, E.; Dominguez, N.; Landeira, G.; Longo, C. Natural history of nonalcoholic steatohepatitis: A longitudinal study of repeat liver biopsies. Hepatology 2004, 40, 820-826.
    • (2004) Hepatology , vol.40 , pp. 820-826
    • Fassio, E.1    Alvarez, E.2    Dominguez, N.3    Landeira, G.4    Longo, C.5
  • 7
    • 33748992321 scopus 로고    scopus 로고
    • Clinical features of nonalcoholic steatohepatitis in Japan: Evidence from the literature
    • Ono, M.; Saibara, T. Clinical features of nonalcoholic steatohepatitis in Japan: Evidence from the literature. J. Gastroenterol. 2006, 41, 725-732.
    • (2006) J. Gastroenterol , vol.41 , pp. 725-732
    • Ono, M.1    Saibara, T.2
  • 8
    • 48649110854 scopus 로고    scopus 로고
    • The role of fatty acids in the development and progression of nonalcoholic fatty liver disease
    • Gentile, C. L.; Pagliassotti, M. J. The role of fatty acids in the development and progression of nonalcoholic fatty liver disease. J. Nutr. Biochem. 2008, 19, 567-576.
    • (2008) J. Nutr. Biochem , vol.19 , pp. 567-576
    • Gentile, C.L.1    Pagliassotti, M.J.2
  • 10
    • 34249792393 scopus 로고    scopus 로고
    • Role of mitochondria in non-alcoholic fatty liver disease
    • Pessayre, D. Role of mitochondria in non-alcoholic fatty liver disease. J. Gastroenterol. Hepatol. 2007, 22, S20-S27.
    • (2007) J. Gastroenterol. Hepatol , vol.22
    • Pessayre, D.1
  • 11
    • 84861543083 scopus 로고    scopus 로고
    • The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association
    • Chalasani, N.; Younossi, Z.; Lavine, J. E.; Diehl, A. M.; Brunt, E. M.; Cusi, K.; Charlton, M.; Sanyal, A. J. The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. Hepatology 2012, 55, 2005-2023.
    • (2012) Hepatology , vol.55 , pp. 2005-2023
    • Chalasani, N.1    Younossi, Z.2    Lavine, J.E.3    Diehl, A.M.4    Brunt, E.M.5    Cusi, K.6    Charlton, M.7    Sanyal, A.J.8
  • 12
    • 43049180323 scopus 로고    scopus 로고
    • Why have antioxidants failed in clinical trials?
    • Steinhubl, S. R. Why have antioxidants failed in clinical trials? Am. J. Cardiol. 2008, 101, 14D-19D.
    • (2008) Am. J. Cardiol , vol.101
    • Steinhubl, S.R.1
  • 13
    • 80052191818 scopus 로고    scopus 로고
    • Review: Antioxidant supplements for primary and secondary prevention do not decrease mortality
    • Hackam, D. G. Review: Antioxidant supplements for primary and secondary prevention do not decrease mortality. ACP J. Club 2007, 147, 4.
    • (2007) ACP J. Club , vol.147 , pp. 4
    • Hackam, D.G.1
  • 15
    • 79960729651 scopus 로고    scopus 로고
    • Mouse patatin-like phospholipase domain-containing 3 influences systemic lipid and glucose homeostasis
    • Qiao, A.; Liang, J.; Ke, Y.; Li, C.; Cui, Y.; Shen, L.; Zhang, H.; Cui, A.; Liu, X.; Liu, C.; et al. Mouse patatin-like phospholipase domain-containing 3 influences systemic lipid and glucose homeostasis. Hepatology 2011, 54, 509-521.
    • (2011) Hepatology , vol.54 , pp. 509-521
    • Qiao, A.1    Liang, J.2    Ke, Y.3    Li, C.4    Cui, Y.5    Shen, L.6    Zhang, H.7    Cui, A.8    Liu, X.9    Liu, C.10
  • 17
    • 77957936457 scopus 로고    scopus 로고
    • I148M patatin-like phospholipase domain-containing 3 gene variant and severity of pediatric nonalcoholic fatty liver disease
    • Valenti, L.; Alisi, A.; Galmozzi, E.; Bartuli, A.; del Menico, B.; Alterio, A.; Dongiovanni, P.; Fargion, S.; Nobili, V. I148M patatin-like phospholipase domain-containing 3 gene variant and severity of pediatric nonalcoholic fatty liver disease. Hepatology 2010, 52, 1274-1280.
    • (2010) Hepatology , vol.52 , pp. 1274-1280
    • Valenti, L.1    Alisi, A.2    Galmozzi, E.3    Bartuli, A.4    del Menico, B.5    Alterio, A.6    Dongiovanni, P.7    Fargion, S.8    Nobili, V.9
  • 18
    • 84862267335 scopus 로고    scopus 로고
    • Genetic polymorphisms of the human PNPLA3 gene are strongly associated with severity of non-alcoholic fatty liver disease in Japanese
    • Japan Study Group of Nonalcoholic Fatty Liver, D
    • Kawaguchi, T.; Sumida, Y.; Umemura, A.; Matsuo, K.; Takahashi, M.; Takamura, T.; Yasui, K.; Saibara, T.; Hashimoto, E.; Kawanaka, M.; et al. Japan Study Group of Nonalcoholic Fatty Liver, D. Genetic polymorphisms of the human PNPLA3 gene are strongly associated with severity of non-alcoholic fatty liver disease in Japanese. PLoS One 2012, 7, e38322.
    • (2012) PLoS One , vol.7
    • Kawaguchi, T.1    Sumida, Y.2    Umemura, A.3    Matsuo, K.4    Takahashi, M.5    Takamura, T.6    Yasui, K.7    Saibara, T.8    Hashimoto, E.9    Kawanaka, M.10
  • 20
    • 84895792814 scopus 로고    scopus 로고
    • The effect of PNPLA3 on fibrosis progression and development of hepatocellular carcinoma: A meta-analysis
    • Singal, A. G.; Manjunath, H.; Yopp, A. C.; Beg, M. S.; Marrero, J. A.; Gopal, P.; Waljee, A. K. The effect of PNPLA3 on fibrosis progression and development of hepatocellular carcinoma: A meta-analysis. Am. J. Gastroenterol. 2014, 109, 325-334.
    • (2014) Am. J. Gastroenterol , vol.109 , pp. 325-334
    • Singal, A.G.1    Manjunath, H.2    Yopp, A.C.3    Beg, M.S.4    Marrero, J.A.5    Gopal, P.6    Waljee, A.K.7
  • 22
    • 84892591294 scopus 로고    scopus 로고
    • No correlation between PNPLA3 rs738409 genotype and fatty liver and hepatic cirrhosis in Japanese patients with HCV
    • Nakamura, M.; Kanda, T.; Nakamoto, S.; Miyamura, T.; Jiang, X.; Wu, S.; Yokosuka, O. No correlation between PNPLA3 rs738409 genotype and fatty liver and hepatic cirrhosis in Japanese patients with HCV. PLoS One 2013, 8, e81312.
    • (2013) PLoS One , vol.8
    • Nakamura, M.1    Kanda, T.2    Nakamoto, S.3    Miyamura, T.4    Jiang, X.5    Wu, S.6    Yokosuka, O.7
  • 24
    • 79957462315 scopus 로고    scopus 로고
    • Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease
    • Sookoian, S.; Pirola, C. J. Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease. Hepatology 2011, 53, 1883-1894.
    • (2011) Hepatology , vol.53 , pp. 1883-1894
    • Sookoian, S.1    Pirola, C.J.2
  • 25
    • 79959573042 scopus 로고    scopus 로고
    • Fatty acids and endotoxin activate inflammasome in hepatocytes which release danger signals to activate immune cells in steatohepatitis
    • Csak, T.; Ganz, M.; Pespisa, J.; Kodys, K.; Dolganiuc, A.; Szabo, G. Fatty acids and endotoxin activate inflammasome in hepatocytes which release danger signals to activate immune cells in steatohepatitis. Hepatology 2011, 54, 133-144.
    • (2011) Hepatology , vol.54 , pp. 133-144
    • Csak, T.1    Ganz, M.2    Pespisa, J.3    Kodys, K.4    Dolganiuc, A.5    Szabo, G.6
  • 27
    • 48249125862 scopus 로고    scopus 로고
    • Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice
    • Cani, P. D.; Bibiloni, R.; Knauf, C.; Waget, A.; Neyrinck, A. M.; Delzenne, N. M.; Burcelin, R. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes 2008, 57, 1470-1481.
    • (2008) Diabetes , vol.57 , pp. 1470-1481
    • Cani, P.D.1    Bibiloni, R.2    Knauf, C.3    Waget, A.4    Neyrinck, A.M.5    Delzenne, N.M.6    Burcelin, R.7
  • 30
    • 65249099918 scopus 로고    scopus 로고
    • Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability
    • Cani, P. D.; Possemiers, S.; van de Wiele, T.; Guiot, Y.; Everard, A.; Rottier, O.; Geurts, L.; Naslain, D.; Neyrinck, A.; Lambert, D. M.; et al. Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability. Gut 2009, 58, 1091-1103.
    • (2009) Gut , vol.58 , pp. 1091-1103
    • Cani, P.D.1    Possemiers, S.2    van de Wiele, T.3    Guiot, Y.4    Everard, A.5    Rottier, O.6    Geurts, L.7    Naslain, D.8    Neyrinck, A.9    Lambert, D.M.10
  • 31
    • 79955569490 scopus 로고    scopus 로고
    • Development of the human gastrointestinal microbiota and insights from high-throughput sequencing
    • Dominguez-Bello, M. G.; Blaser, M. J.; Ley, R. E.; Knight, R. Development of the human gastrointestinal microbiota and insights from high-throughput sequencing. Gastroenterology 2011, 140, 1713-1719.
    • (2011) Gastroenterology , vol.140 , pp. 1713-1719
    • Dominguez-Bello, M.G.1    Blaser, M.J.2    Ley, R.E.3    Knight, R.4
  • 33
    • 84898824175 scopus 로고    scopus 로고
    • Interactions between the intestinal microbiome and liver diseases
    • 2014, doi: 10. 1053/j. gastro. 01. 020
    • Schnabl, B.; Brenner, D. A. Interactions between the intestinal microbiome and liver diseases. Gastroenterology 2014, doi: 10. 1053/j. gastro. 2014. 01. 020.
    • (2014) Gastroenterology
    • Schnabl, B.1    Brenner, D.A.2
  • 36
  • 37
    • 84855400121 scopus 로고    scopus 로고
    • Supplementation with probiotics modifies gut flora and attenuates liver fat accumulation in rat nonalcoholic fatty liver disease model
    • Xu, R. Y.; Wan, Y. P.; Fang, Q. Y.; Lu, W.; Cai, W. Supplementation with probiotics modifies gut flora and attenuates liver fat accumulation in rat nonalcoholic fatty liver disease model. J. Clin. Biochem. Nutr. 2012, 50, 72-77.
    • (2012) J. Clin. Biochem. Nutr , vol.50 , pp. 72-77
    • Xu, R.Y.1    Wan, Y.P.2    Fang, Q.Y.3    Lu, W.4    Cai, W.5
  • 38
    • 84898059530 scopus 로고    scopus 로고
    • Antibiotic treatments and microbes in the gut
    • Macfarlane, S. Antibiotic treatments and microbes in the gut. Environ. Microbiol. 2014, 16, 919-924.
    • (2014) Environ. Microbiol , vol.16 , pp. 919-924
    • Macfarlane, S.1
  • 39
    • 84880425040 scopus 로고    scopus 로고
    • Epidemiology and natural history of patients with NAFLD
    • Bhala, N.; Jouness, R. I.; Bugianesi, E. Epidemiology and natural history of patients with NAFLD. Curr. Pharm. Des. 2013, 19, 5169-5176.
    • (2013) Curr. Pharm. Des , vol.19 , pp. 5169-5176
    • Bhala, N.1    Jouness, R.I.2    Bugianesi, E.3
  • 42
    • 84899489867 scopus 로고    scopus 로고
    • The relationship between sarcopenia and non-alcoholic fatty liver disease: The Korean sarcopenic obesity study
    • doi: 10. 1002/hep. 26716
    • Hong, H. C.; Hwang, S. Y.; Choi, H. Y.; Yoo, H. J.; Seo, J. A.; Kim, S. G.; Kim, N. H.; Baik, S. H.; Choi, D. S.; Choi, K. M. The relationship between sarcopenia and non-alcoholic fatty liver disease: The Korean sarcopenic obesity study. Hepatology 2013, doi: 10. 1002/hep. 26716.
    • (2013) Hepatology
    • Hong, H.C.1    Hwang, S.Y.2    Choi, H.Y.3    Yoo, H.J.4    Seo, J.A.5    Kim, S.G.6    Kim, N.H.7    Baik, S.H.8    Choi, D.S.9    Choi, K.M.10
  • 45
    • 84865553250 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis versus steatosis: Adipose tissue insulin resistance and dysfunctional response to fat ingestion predict liver injury and altered glucose and lipoprotein metabolism
    • Musso, G.; Cassader, M.; de Michieli, F.; Rosina, F.; Orlandi, F.; Gambino, R. Nonalcoholic steatohepatitis versus steatosis: Adipose tissue insulin resistance and dysfunctional response to fat ingestion predict liver injury and altered glucose and lipoprotein metabolism. Hepatology 2012, 56, 933-942.
    • (2012) Hepatology , vol.56 , pp. 933-942
    • Musso, G.1    Cassader, M.2    de Michieli, F.3    Rosina, F.4    Orlandi, F.5    Gambino, R.6
  • 46
    • 35748957503 scopus 로고    scopus 로고
    • The physiology of glucagon-like peptide 1
    • Holst, J. J. The physiology of glucagon-like peptide 1. Physiol. Rev. 2007, 87, 1409-1439.
    • (2007) Physiol. Rev , vol.87 , pp. 1409-1439
    • Holst, J.J.1
  • 47
  • 49
    • 79951810722 scopus 로고    scopus 로고
    • Serum total adiponectin in nonalcoholic fatty liver disease: A systematic review and meta-analysis
    • Polyzos, S. A.; Toulis, K. A.; Goulis, D. G.; Zavos, C.; Kountouras, J. Serum total adiponectin in nonalcoholic fatty liver disease: A systematic review and meta-analysis. Metabolism 2011, 60, 313-326.
    • (2011) Metabolism , vol.60 , pp. 313-326
    • Polyzos, S.A.1    Toulis, K.A.2    Goulis, D.G.3    Zavos, C.4    Kountouras, J.5
  • 50
    • 84866141957 scopus 로고    scopus 로고
    • Immunological functions of leptin and adiponectin
    • Carbone, F.; La Rocca, C.; Matarese, G. Immunological functions of leptin and adiponectin. Biochimie 2012, 94, 2082-2088.
    • (2012) Biochimie , vol.94 , pp. 2082-2088
    • Carbone, F.1    La Rocca, C.2    Matarese, G.3
  • 54
    • 58849119649 scopus 로고    scopus 로고
    • Expression of adiponectin and its receptors in livers of morbidly obese patients with non-alcoholic fatty liver disease
    • Ma, H.; Gomez, V.; Lu, L.; Yang, X.; Wu, X.; Xiao, S. Y. Expression of adiponectin and its receptors in livers of morbidly obese patients with non-alcoholic fatty liver disease. J. Gastroenterol. Hepatol. 2009, 24, 233-237.
    • (2009) J. Gastroenterol. Hepatol , vol.24 , pp. 233-237
    • Ma, H.1    Gomez, V.2    Lu, L.3    Yang, X.4    Wu, X.5    Xiao, S.Y.6
  • 55
    • 34250356015 scopus 로고    scopus 로고
    • Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis
    • Yamaguchi, K.; Yang, L.; McCall, S.; Huang, J.; Yu, X. X.; Pandey, S. K.; Bhanot, S.; Monia, B. P.; Li, Y. X.; Diehl, A. M. Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis. Hepatology 2007, 45, 1366-1374.
    • (2007) Hepatology , vol.45 , pp. 1366-1374
    • Yamaguchi, K.1    Yang, L.2    McCall, S.3    Huang, J.4    Yu, X.X.5    Pandey, S.K.6    Bhanot, S.7    Monia, B.P.8    Li, Y.X.9    Diehl, A.M.10
  • 56
    • 23044450772 scopus 로고    scopus 로고
    • Antisense oligonucleotide reduction of DGAT2 expression improves hepatic steatosis and hyperlipidemia in obese mice
    • Yu, X. X.; Murray, S. F.; Pandey, S. K.; Booten, S. L.; Bao, D.; Song, X. Z.; Kelly, S.; Chen, S.; McKay, R.; Monia, B. P.; et al. Antisense oligonucleotide reduction of DGAT2 expression improves hepatic steatosis and hyperlipidemia in obese mice. Hepatology 2005, 42, 362-371.
    • (2005) Hepatology , vol.42 , pp. 362-371
    • Yu, X.X.1    Murray, S.F.2    Pandey, S.K.3    Booten, S.L.4    Bao, D.5    Song, X.Z.6    Kelly, S.7    Chen, S.8    McKay, R.9    Monia, B.P.10
  • 57
  • 58
    • 77956119396 scopus 로고    scopus 로고
    • Simple non-invasive fibrosis scoring systems can reliably exclude advanced fibrosis in patients with non-alcoholic fatty liver disease
    • McPherson, S.; Stewart, S. F.; Henderson, E.; Burt, A. D.; Day, C. P. Simple non-invasive fibrosis scoring systems can reliably exclude advanced fibrosis in patients with non-alcoholic fatty liver disease. Gut 2010, 59, 1265-1269.
    • (2010) Gut , vol.59 , pp. 1265-1269
    • McPherson, S.1    Stewart, S.F.2    Henderson, E.3    Burt, A.D.4    Day, C.P.5
  • 60
    • 84876293750 scopus 로고    scopus 로고
    • Non-invasive diagnosis of non-alcoholic fatty liver disease. A critical appraisal
    • Machado, M. V.; Cortez-Pinto, H. Non-invasive diagnosis of non-alcoholic fatty liver disease. A critical appraisal. J. Hepatol. 2013, 58, 1007-1019.
    • (2013) J. Hepatol , vol.58 , pp. 1007-1019
    • Machado, M.V.1    Cortez-Pinto, H.2
  • 61
    • 84883740164 scopus 로고    scopus 로고
    • Serum cytokeratin-18 fragment levels are useful biomarkers for nonalcoholic steatohepatitis in children
    • Feldstein, A. E.; Alkhouri, N.; de Vito, R.; Alisi, A.; Lopez, R.; Nobili, V. Serum cytokeratin-18 fragment levels are useful biomarkers for nonalcoholic steatohepatitis in children. Am. J. Gastroenterol. 2013, 108, 1526-1531.
    • (2013) Am. J. Gastroenterol , vol.108 , pp. 1526-1531
    • Feldstein, A.E.1    Alkhouri, N.2    de Vito, R.3    Alisi, A.4    Lopez, R.5    Nobili, V.6
  • 62
    • 80555136061 scopus 로고    scopus 로고
    • Meta-analysis: Natural history of non-alcoholic fatty liver disease (NAFLD) and diagnostic accuracy of non-invasive tests for liver disease severity
    • Musso, G.; Gambino, R.; Cassader, M.; Pagano, G. Meta-analysis: Natural history of non-alcoholic fatty liver disease (NAFLD) and diagnostic accuracy of non-invasive tests for liver disease severity. Ann. Med. 2011, 43, 617-649.
    • (2011) Ann. Med , vol.43 , pp. 617-649
    • Musso, G.1    Gambino, R.2    Cassader, M.3    Pagano, G.4
  • 63
    • 84890547086 scopus 로고    scopus 로고
    • Limited value of plasma cytokeratin-18 as a biomarker for NASH and fibrosis in patients with non-alcoholic fatty liver disease
    • Cusi, K.; Chang, Z.; Harrison, S.; Lomonaco, R.; Bril, F.; Orsak, B.; Ortiz-Lopez, C.; Hecht, J.; Feldstein, A. E.; Webb, A.; et al. Limited value of plasma cytokeratin-18 as a biomarker for NASH and fibrosis in patients with non-alcoholic fatty liver disease. J. Hepatol. 2014, 60, 167-174.
    • (2014) J. Hepatol , vol.60 , pp. 167-174
    • Cusi, K.1    Chang, Z.2    Harrison, S.3    Lomonaco, R.4    Bril, F.5    Orsak, B.6    Ortiz-Lopez, C.7    Hecht, J.8    Feldstein, A.E.9    Webb, A.10
  • 65
    • 84872493396 scopus 로고    scopus 로고
    • Cholesterol metabolism and the pathogenesis of non-alcoholic steatohepatitis
    • Musso, G.; Gambino, R.; Cassader, M. Cholesterol metabolism and the pathogenesis of non-alcoholic steatohepatitis. Prog. Lipid Res. 2013, 52, 175-191.
    • (2013) Prog. Lipid Res , vol.52 , pp. 175-191
    • Musso, G.1    Gambino, R.2    Cassader, M.3
  • 66
  • 67
    • 77950523710 scopus 로고    scopus 로고
    • The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation
    • Park, S. W.; Zhou, Y.; Lee, J.; Lu, A.; Sun, C.; Chung, J.; Ueki, K.; Ozcan, U. The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation. Nat. Med. 2010, 16, 429-437.
    • (2010) Nat. Med , vol.16 , pp. 429-437
    • Park, S.W.1    Zhou, Y.2    Lee, J.3    Lu, A.4    Sun, C.5    Chung, J.6    Ueki, K.7    Ozcan, U.8
  • 69
    • 78650615554 scopus 로고    scopus 로고
    • 2+-ATPase 2b is a major regulator of endoplasmic reticulum stress and glucose homeostasis in obesity
    • 2+-ATPase 2b is a major regulator of endoplasmic reticulum stress and glucose homeostasis in obesity. Proc. Natl. Acad. Sci. USA 2010, 107, 19320-19325.
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 19320-19325
    • Park, S.W.1    Zhou, Y.2    Lee, J.3    Ozcan, U.4
  • 71
    • 84891324421 scopus 로고    scopus 로고
    • The adaptive endoplasmic reticulum stress response to lipotoxicity in progressive human nonalcoholic fatty liver disease
    • Lake, A. D.; Novak, P.; Hardwick, R. N.; Flores-Keown, B.; Zhao, F.; Klimecki, W. T.; Cherrington, N. J. The adaptive endoplasmic reticulum stress response to lipotoxicity in progressive human nonalcoholic fatty liver disease. Toxicol. Sci. 2014, 137, 26-35.
    • (2014) Toxicol. Sci , vol.137 , pp. 26-35
    • Lake, A.D.1    Novak, P.2    Hardwick, R.N.3    Flores-Keown, B.4    Zhao, F.5    Klimecki, W.T.6    Cherrington, N.J.7
  • 72
    • 84878616469 scopus 로고    scopus 로고
    • STING-dependent recognition of cyclic di-AMP mediates type I interferon responses during Chlamydia trachomatis infection
    • Barker, J. R.; Koestler, B. J.; Carpenter, V. K.; Burdette, D. L.; Waters, C. M.; Vance, R. E.; Valdivia, R. H. STING-dependent recognition of cyclic di-AMP mediates type I interferon responses during Chlamydia trachomatis infection. mBio 2013, 4, e00018: 1-e00018: 13.
    • (2013) mBio , vol.4
    • Barker, J.R.1    Koestler, B.J.2    Carpenter, V.K.3    Burdette, D.L.4    Waters, C.M.5    Vance, R.E.6    Valdivia, R.H.7
  • 75
    • 34249699540 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis and cancer
    • Bugianesi, E. Non-alcoholic steatohepatitis and cancer. Clin. Liver Dis. 2007, 11, 191-207.
    • (2007) Clin. Liver Dis , vol.11 , pp. 191-207
    • Bugianesi, E.1
  • 77
    • 0033520771 scopus 로고    scopus 로고
    • Alterations in liver ATP homeostasis in human nonalcoholic steatohepatitis: A pilot study
    • Cortez-Pinto, H.; Chatham, J.; Chacko, V. P.; Arnold, C.; Rashid, A.; Diehl, A. M. Alterations in liver ATP homeostasis in human nonalcoholic steatohepatitis: A pilot study. JAMA 1999, 282, 1659-1664.
    • (1999) JAMA , vol.282 , pp. 1659-1664
    • Cortez-Pinto, H.1    Chatham, J.2    Chacko, V.P.3    Arnold, C.4    Rashid, A.5    Diehl, A.M.6
  • 79
    • 77952541558 scopus 로고    scopus 로고
    • The sites and topology of mitochondrial superoxide production
    • Brand, M. D. The sites and topology of mitochondrial superoxide production. Exp. Gerontol. 2010, 45, 466-472.
    • (2010) Exp. Gerontol , vol.45 , pp. 466-472
    • Brand, M.D.1
  • 80
    • 79251532050 scopus 로고    scopus 로고
    • Relationship between the pattern of hepatic iron deposition and histological severity in nonalcoholic fatty liver disease
    • Nelson, J. E.; Wilson, L.; Brunt, E. M.; Yeh, M. M.; Kleiner, D. E.; Unalp-Arida, A.; Kowdley, K. V. Relationship between the pattern of hepatic iron deposition and histological severity in nonalcoholic fatty liver disease. Hepatology 2011, 53, 448-457.
    • (2011) Hepatology , vol.53 , pp. 448-457
    • Nelson, J.E.1    Wilson, L.2    Brunt, E.M.3    Yeh, M.M.4    Kleiner, D.E.5    Unalp-Arida, A.6    Kowdley, K.V.7
  • 81
    • 84902533159 scopus 로고    scopus 로고
    • Iron deficiency in patients with nonalcoholic fatty liver disease is associated with obesity, female gender, and low serum hepcidin
    • 2013, doi: 10. 1016/j. cgh. 11. 017
    • Siddique, A.; Nelson, J. E.; Aouizerat, B.; Yeh, M. M.; Kowdley, K. V.; Network, N. C. R. Iron deficiency in patients with nonalcoholic fatty liver disease is associated with obesity, female gender, and low serum hepcidin. Clin. Gastroenterol. Hepatol. 2013, doi: 10. 1016/j. cgh. 2013. 11. 017.
    • (2013) Clin. Gastroenterol. Hepatol
    • Siddique, A.1    Nelson, J.E.2    Aouizerat, B.3    Yeh, M.M.4    Kowdley, K.V.5    Network, N.C.R.6
  • 82
    • 79957960940 scopus 로고    scopus 로고
    • Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network
    • Scarpulla, R. C. Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network. Biochim. Biophys. Acta 2011, 1813, 1269-1278.
    • (2011) Biochim. Biophys. Acta , vol.1813 , pp. 1269-1278
    • Scarpulla, R.C.1
  • 83
    • 79959739128 scopus 로고    scopus 로고
    • Fatty liver is associated with impaired activity of PPARgamma-coactivator 1alpha (PGC1alpha) and mitochondrial biogenesis in mice
    • Aharoni-Simon, M.; Hann-Obercyger, M.; Pen, S.; Madar, Z.; Tirosh, O. Fatty liver is associated with impaired activity of PPARgamma-coactivator 1alpha (PGC1alpha) and mitochondrial biogenesis in mice. Lab. Investig. 2011, 91, 1018-1028.
    • (2011) Lab. Investig , vol.91 , pp. 1018-1028
    • Aharoni-Simon, M.1    Hann-Obercyger, M.2    Pen, S.3    Madar, Z.4    Tirosh, O.5
  • 84
    • 84863526545 scopus 로고    scopus 로고
    • Stat3-mediated activation of microRNA-23a suppresses gluconeogenesis in hepatocellular carcinoma by down-regulating glucose-6-phosphatase and peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
    • Wang, B.; Hsu, S. H.; Frankel, W.; Ghoshal, K.; Jacob, S. T. Stat3-mediated activation of microRNA-23a suppresses gluconeogenesis in hepatocellular carcinoma by down-regulating glucose-6-phosphatase and peroxisome proliferator-activated receptor gamma, coactivator 1 alpha. Hepatology 2012, 56, 186-197.
    • (2012) Hepatology , vol.56 , pp. 186-197
    • Wang, B.1    Hsu, S.H.2    Frankel, W.3    Ghoshal, K.4    Jacob, S.T.5
  • 86
    • 84655169624 scopus 로고    scopus 로고
    • Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis
    • Rolo, A. P.; Teodoro, J. S.; Palmeira, C. M. Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis. Free Radic. Biol. Med. 2012, 52, 59-69.
    • (2012) Free Radic. Biol. Med , vol.52 , pp. 59-69
    • Rolo, A.P.1    Teodoro, J.S.2    Palmeira, C.M.3
  • 93
    • 77951602823 scopus 로고    scopus 로고
    • Nuclear receptor transrepression pathways that regulate inflammation in macrophages and T cells
    • Glass, C. K.; Saijo, K. Nuclear receptor transrepression pathways that regulate inflammation in macrophages and T cells. Nat. Rev. Immunol. 2010, 10, 365-376.
    • (2010) Nat. Rev. Immunol , vol.10 , pp. 365-376
    • Glass, C.K.1    Saijo, K.2
  • 96
    • 84868671526 scopus 로고    scopus 로고
    • Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase
    • Talukdar, S.; Oh da, Y.; Bandyopadhyay, G.; Li, D.; Xu, J.; McNelis, J.; Lu, M.; Li, P.; Yan, Q.; Zhu, Y.; et al. Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase. Nat. Med. 2012, 18, 1407-1412.
    • (2012) Nat. Med , vol.18 , pp. 1407-1412
    • Talukdar, S.1    Oh da, Y.2    Bandyopadhyay, G.3    Li, D.4    Xu, J.5    McNelis, J.6    Lu, M.7    Li, P.8    Yan, Q.9    Zhu, Y.10
  • 98
    • 84873289589 scopus 로고    scopus 로고
    • Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice
    • Miura, K.; Yang, L.; van Rooijen, N.; Brenner, D. A.; Ohnishi, H.; Seki, E. Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice. Hepatology 2013, 57, 577-589.
    • (2013) Hepatology , vol.57 , pp. 577-589
    • Miura, K.1    Yang, L.2    van Rooijen, N.3    Brenner, D.A.4    Ohnishi, H.5    Seki, E.6
  • 100
    • 84894875873 scopus 로고    scopus 로고
    • Free cholesterol accumulation in hepatic stellate cells: Mechanism of liver fibrosis aggravation in nonalcoholic steatohepatitis in mice
    • Tomita, K.; Teratani, T.; Suzuki, T.; Shimizu, M.; Sato, H.; Narimatsu, K.; Okada, Y.; Kurihara, C.; Irie, R.; Yokoyama, H.; et al. Free cholesterol accumulation in hepatic stellate cells: Mechanism of liver fibrosis aggravation in nonalcoholic steatohepatitis in mice. Hepatology 2014, 59, 154-169.
    • (2014) Hepatology , vol.59 , pp. 154-169
    • Tomita, K.1    Teratani, T.2    Suzuki, T.3    Shimizu, M.4    Sato, H.5    Narimatsu, K.6    Okada, Y.7    Kurihara, C.8    Irie, R.9    Yokoyama, H.10
  • 104
    • 79955527226 scopus 로고    scopus 로고
    • TLR5-deficient mice lack basal inflammatory and metabolic defects but exhibit impaired CD4 T cell responses to a flagellated pathogen
    • Letran, S. E.; Lee, S. J.; Atif, S. M.; Flores-Langarica, A.; Uematsu, S.; Akira, S.; Cunningham, A. F.; McSorley, S. J. TLR5-deficient mice lack basal inflammatory and metabolic defects but exhibit impaired CD4 T cell responses to a flagellated pathogen. J. Immunol. 2011, 186, 5406-5412.
    • (2011) J. Immunol , vol.186 , pp. 5406-5412
    • Letran, S.E.1    Lee, S.J.2    Atif, S.M.3    Flores-Langarica, A.4    Uematsu, S.5    Akira, S.6    Cunningham, A.F.7    McSorley, S.J.8
  • 105
    • 78049337151 scopus 로고    scopus 로고
    • Effects of diet and physical activity interventions on weight loss and cardiometabolic risk factors in severely obese adults: A randomized trial
    • Goodpaster, B. H.; Delany, J. P.; Otto, A. D.; Kuller, L.; Vockley, J.; South-Paul, J. E.; Thomas, S. B.; Brown, J.; McTigue, K.; Hames, K. C.; et al. Effects of diet and physical activity interventions on weight loss and cardiometabolic risk factors in severely obese adults: A randomized trial. JAMA 2010, 304, 1795-1802.
    • (2010) JAMA , vol.304 , pp. 1795-1802
    • Goodpaster, B.H.1    Delany, J.P.2    Otto, A.D.3    Kuller, L.4    Vockley, J.5    South-Paul, J.E.6    Thomas, S.B.7    Brown, J.8    McTigue, K.9    Hames, K.C.10
  • 106
    • 84866736015 scopus 로고    scopus 로고
    • Dietary trans-fatty acid induced NASH is normalized following loss of trans-fatty acids from hepatic lipid pools
    • Neuschwander-Tetri, B. A.; Ford, D. A.; Acharya, S.; Gilkey, G.; Basaranoglu, M.; Tetri, L. H.; Brunt, E. M. Dietary trans-fatty acid induced NASH is normalized following loss of trans-fatty acids from hepatic lipid pools. Lipids 2012, 47, 941-950.
    • (2012) Lipids , vol.47 , pp. 941-950
    • Neuschwander-Tetri, B.A.1    Ford, D.A.2    Acharya, S.3    Gilkey, G.4    Basaranoglu, M.5    Tetri, L.H.6    Brunt, E.M.7
  • 107
    • 38449101907 scopus 로고    scopus 로고
    • Thought suppression in obese and non-obese restrained eaters: Piece of cake or forbidden fruit?
    • Soetens, B.; Braet, C.; Moens, E. Thought suppression in obese and non-obese restrained eaters: Piece of cake or forbidden fruit? Eur. Eat. Disord. Rev. 2008, 16, 67-76.
    • (2008) Eur. Eat. Disord. Rev , vol.16 , pp. 67-76
    • Soetens, B.1    Braet, C.2    Moens, E.3
  • 108
    • 84861591910 scopus 로고    scopus 로고
    • The diagnosis and management of non-alcoholic fatty liver disease: Practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology
    • Chalasani, N.; Younossi, Z.; Lavine, J. E.; Diehl, A. M.; Brunt, E. M.; Cusi, K.; Charlton, M.; Sanyal, A. J. The diagnosis and management of non-alcoholic fatty liver disease: Practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology. Gastroenterology 2012, 142, 1592-1609.
    • (2012) Gastroenterology , vol.142 , pp. 1592-1609
    • Chalasani, N.1    Younossi, Z.2    Lavine, J.E.3    Diehl, A.M.4    Brunt, E.M.5    Cusi, K.6    Charlton, M.7    Sanyal, A.J.8
  • 111
    • 84881167883 scopus 로고    scopus 로고
    • Ten misconceptions about antioxidants
    • Bast, A.; Haenen, G. R. Ten misconceptions about antioxidants. Trends Pharmacol. Sci. 2013, 34, 430-436.
    • (2013) Trends Pharmacol. Sci , vol.34 , pp. 430-436
    • Bast, A.1    Haenen, G.R.2
  • 112
    • 84875181661 scopus 로고    scopus 로고
    • Oxidants, antioxidants and the current incurability of metastatic cancers
    • Watson, J. Oxidants, antioxidants and the current incurability of metastatic cancers. Open Biol. 2013, 3, 120144.
    • (2013) Open Biol , vol.3 , pp. 120144
    • Watson, J.1
  • 114
    • 67650071137 scopus 로고    scopus 로고
    • Targeting cancer cells by ROS-mediated mechanisms: A radical therapeutic approach?
    • Trachootham, D.; Alexandre, J.; Huang, P. Targeting cancer cells by ROS-mediated mechanisms: A radical therapeutic approach? Nat. Rev. Drug Discov. 2009, 8, 579-591.
    • (2009) Nat. Rev. Drug Discov , vol.8 , pp. 579-591
    • Trachootham, D.1    Alexandre, J.2    Huang, P.3
  • 115
    • 80052226753 scopus 로고    scopus 로고
    • Recent progress toward hydrogen medicine: Potential of molecular hydrogen for preventive and therapeutic applications
    • Ohta, S. Recent progress toward hydrogen medicine: Potential of molecular hydrogen for preventive and therapeutic applications. Curr. Pharm. Des. 2011, 17, 2241-2252.
    • (2011) Curr. Pharm. Des , vol.17 , pp. 2241-2252
    • Ohta, S.1
  • 116
    • 84862517200 scopus 로고    scopus 로고
    • Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-alcoholic fatty liver disease (NAFLD): A systematic review and meta-analysis of randomised trials
    • Musso, G.; Cassader, M.; Rosina, F.; Gambino, R. Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-alcoholic fatty liver disease (NAFLD): A systematic review and meta-analysis of randomised trials. Diabetologia 2012, 55, 885-904.
    • (2012) Diabetologia , vol.55 , pp. 885-904
    • Musso, G.1    Cassader, M.2    Rosina, F.3    Gambino, R.4
  • 117
    • 80052517174 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor activation stimulates hepatic lipid oxidation and restores hepatic signalling alteration induced by a high-fat diet in nonalcoholic steatohepatitis
    • Svegliati-Baroni, G.; Saccomanno, S.; Rychlicki, C.; Agostinelli, L.; de Minicis, S.; Candelaresi, C.; Faraci, G.; Pacetti, D.; Vivarelli, M.; Nicolini, D.; et al. Glucagon-like peptide-1 receptor activation stimulates hepatic lipid oxidation and restores hepatic signalling alteration induced by a high-fat diet in nonalcoholic steatohepatitis. Liver Int. 2011, 31, 1285-1297.
    • (2011) Liver Int , vol.31 , pp. 1285-1297
    • Svegliati-Baroni, G.1    Saccomanno, S.2    Rychlicki, C.3    Agostinelli, L.4    de Minicis, S.5    Candelaresi, C.6    Faraci, G.7    Pacetti, D.8    Vivarelli, M.9    Nicolini, D.10
  • 118
    • 84870817823 scopus 로고    scopus 로고
    • Improved glycaemia correlates with liver fat reduction in obese, type 2 diabetes, patients given glucagon-like peptide-1 (GLP-1) receptor agonists
    • Cuthbertson, D. J.; Irwin, A.; Gardner, C. J.; Daousi, C.; Purewal, T.; Furlong, N.; Goenka, N.; Thomas, E. L.; Adams, V. L.; Pushpakom, S. P.; et al. Improved glycaemia correlates with liver fat reduction in obese, type 2 diabetes, patients given glucagon-like peptide-1 (GLP-1) receptor agonists. PLoS One 2012, 7, e50117.
    • (2012) PLoS One , vol.7
    • Cuthbertson, D.J.1    Irwin, A.2    Gardner, C.J.3    Daousi, C.4    Purewal, T.5    Furlong, N.6    Goenka, N.7    Thomas, E.L.8    Adams, V.L.9    Pushpakom, S.P.10
  • 120
    • 84867165316 scopus 로고    scopus 로고
    • Pentoxifylline decreases oxidized lipid products in nonalcoholic steatohepatitis: New evidence on the potential therapeutic mechanism
    • Zein, C. O.; Lopez, R.; Fu, X.; Kirwan, J. P.; Yerian, L. M.; McCullough, A. J.; Hazen, S. L.; Feldstein, A. E. Pentoxifylline decreases oxidized lipid products in nonalcoholic steatohepatitis: New evidence on the potential therapeutic mechanism. Hepatology 2012, 56, 1291-1299.
    • (2012) Hepatology , vol.56 , pp. 1291-1299
    • Zein, C.O.1    Lopez, R.2    Fu, X.3    Kirwan, J.P.4    Yerian, L.M.5    McCullough, A.J.6    Hazen, S.L.7    Feldstein, A.E.8
  • 122
    • 74949102941 scopus 로고    scopus 로고
    • A pilot study using simvastatin in the treatment of nonalcoholic steatohepatitis: A randomized placebo-controlled trial
    • Nelson, A.; Torres, D. M.; Morgan, A. E.; Fincke, C.; Harrison, S. A. A pilot study using simvastatin in the treatment of nonalcoholic steatohepatitis: A randomized placebo-controlled trial. J. Clin. Gastroenterol. 2009, 43, 990-994.
    • (2009) J. Clin. Gastroenterol , vol.43 , pp. 990-994
    • Nelson, A.1    Torres, D.M.2    Morgan, A.E.3    Fincke, C.4    Harrison, S.A.5
  • 123
    • 36549013633 scopus 로고    scopus 로고
    • Ezetimibe improves liver steatosis and insulin resistance in obese rat model of metabolic syndrome
    • Deushi, M.; Nomura, M.; Kawakami, A.; Haraguchi, M.; Ito, M.; Okazaki, M.; Ishii, H.; Yoshida, M. Ezetimibe improves liver steatosis and insulin resistance in obese rat model of metabolic syndrome. FEBS Lett. 2007, 581, 5664-5670.
    • (2007) FEBS Lett , vol.581 , pp. 5664-5670
    • Deushi, M.1    Nomura, M.2    Kawakami, A.3    Haraguchi, M.4    Ito, M.5    Okazaki, M.6    Ishii, H.7    Yoshida, M.8
  • 126
    • 77955699301 scopus 로고    scopus 로고
    • High-dose ursodeoxycholic acid therapy for nonalcoholic steatohepatitis: A double-blind, randomized, placebo-controlled trial
    • Leuschner, U. F.; Lindenthal, B.; Herrmann, G.; Arnold, J. C.; Rossle, M.; Cordes, H. J.; Zeuzem, S.; Hein, J.; Berg, T. High-dose ursodeoxycholic acid therapy for nonalcoholic steatohepatitis: A double-blind, randomized, placebo-controlled trial. Hepatology 2010, 52, 472-479.
    • (2010) Hepatology , vol.52 , pp. 472-479
    • Leuschner, U.F.1    Lindenthal, B.2    Herrmann, G.3    Arnold, J.C.4    Rossle, M.5    Cordes, H.J.6    Zeuzem, S.7    Hein, J.8    Berg, T.9
  • 128
    • 84881187537 scopus 로고    scopus 로고
    • Opportunistic infections with anti-tumor necrosis factor-alpha therapy in inflammatory bowel disease: Meta-analysis of randomized controlled trials
    • Ford, A. C.; Peyrin-Biroulet, L. Opportunistic infections with anti-tumor necrosis factor-alpha therapy in inflammatory bowel disease: Meta-analysis of randomized controlled trials. Am. J. Gastroenterol. 2013, 108, 1268-1276.
    • (2013) Am. J. Gastroenterol , vol.108 , pp. 1268-1276
    • Ford, A.C.1    Peyrin-Biroulet, L.2
  • 129
    • 84877798095 scopus 로고    scopus 로고
    • Butyrate-producing probiotics reduce nonalcoholic fatty liver disease progression in rats: New insight into the probiotics for the gut-liver axis
    • Endo, H.; Niioka, M.; Kobayashi, N.; Tanaka, M.; Watanabe, T. Butyrate-producing probiotics reduce nonalcoholic fatty liver disease progression in rats: New insight into the probiotics for the gut-liver axis. PLoS One 2013, 8, e63388.
    • (2013) PLoS One , vol.8
    • Endo, H.1    Niioka, M.2    Kobayashi, N.3    Tanaka, M.4    Watanabe, T.5
  • 131
    • 77953229020 scopus 로고    scopus 로고
    • L-carnitine supplementation to diet: A new tool in treatment of nonalcoholic steatohepatitis-A randomized and controlled clinical trial
    • Malaguarnera, M.; Gargante, M. P.; Russo, C.; Antic, T.; Vacante, M.; Avitabile, T.; Li Volti, G.; Galvano, F. L-carnitine supplementation to diet: A new tool in treatment of nonalcoholic steatohepatitis-A randomized and controlled clinical trial. Am. J. Gastroenterol. 2010, 105, 1338-1345.
    • (2010) Am. J. Gastroenterol , vol.105 , pp. 1338-1345
    • Malaguarnera, M.1    Gargante, M.P.2    Russo, C.3    Antic, T.4    Vacante, M.5    Avitabile, T.6    Li Volti, G.7    Galvano, F.8
  • 132
    • 81055124193 scopus 로고    scopus 로고
    • L-carnitine ameliorated fatty liver in high-calorie diet/STZ-induced type 2 diabetic mice by improving mitochondrial function
    • Xia, Y.; Li, Q.; Zhong, W.; Dong, J.; Wang, Z.; Wang, C. L-carnitine ameliorated fatty liver in high-calorie diet/STZ-induced type 2 diabetic mice by improving mitochondrial function. Diabetol. Metab. Syndr. 2011, 3, 31.
    • (2011) Diabetol. Metab. Syndr , vol.3 , pp. 31
    • Xia, Y.1    Li, Q.2    Zhong, W.3    Dong, J.4    Wang, Z.5    Wang, C.6
  • 133
    • 84891447671 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis and hepatocellular carcinoma: Implications for lycopene intervention
    • Ip, B. C.; Wang, X. D. Non-alcoholic steatohepatitis and hepatocellular carcinoma: Implications for lycopene intervention. Nutrients 2014, 6, 124-162.
    • (2014) Nutrients , vol.6 , pp. 124-162
    • Ip, B.C.1    Wang, X.D.2
  • 134
    • 84890493012 scopus 로고    scopus 로고
    • Lycopene metabolite, apo-10'-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice
    • Ip, B. C.; Hu, K. Q.; Liu, C.; Smith, D. E.; Obin, M. S.; Ausman, L. M.; Wang, X. D. Lycopene metabolite, apo-10'-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice. Cancer Prev. Res. 2013, 6, 1304-1316.
    • (2013) Cancer Prev. Res , vol.6 , pp. 1304-1316
    • Ip, B.C.1    Hu, K.Q.2    Liu, C.3    Smith, D.E.4    Obin, M.S.5    Ausman, L.M.6    Wang, X.D.7
  • 135
    • 84863011904 scopus 로고    scopus 로고
    • Potent PPARalpha activator derived from tomato juice, 13-oxo-9, 11-octadecadienoic acid, decreases plasma and hepatic triglyceride in obese diabetic mice
    • Kim, Y. I.; Hirai, S.; Goto, T.; Ohyane, C.; Takahashi, H.; Tsugane, T.; Konishi, C.; Fujii, T.; Inai, S.; Iijima, Y.; et al. Potent PPARalpha activator derived from tomato juice, 13-oxo-9, 11-octadecadienoic acid, decreases plasma and hepatic triglyceride in obese diabetic mice. PLoS One 2012, 7, e31317.
    • (2012) PLoS One , vol.7
    • Kim, Y.I.1    Hirai, S.2    Goto, T.3    Ohyane, C.4    Takahashi, H.5    Tsugane, T.6    Konishi, C.7    Fujii, T.8    Inai, S.9    Iijima, Y.10
  • 137
    • 79951670028 scopus 로고    scopus 로고
    • The protective role of hydrogen-rich saline in experimental liver injury in mice
    • Sun, H.; Chen, L.; Zhou, W.; Hu, L.; Li, L.; Tu, Q.; Chang, Y.; Liu, Q.; Sun, X.; Wu, M.; et al. The protective role of hydrogen-rich saline in experimental liver injury in mice. J. Hepatol. 2011, 54, 471-480.
    • (2011) J. Hepatol , vol.54 , pp. 471-480
    • Sun, H.1    Chen, L.2    Zhou, W.3    Hu, L.4    Li, L.5    Tu, Q.6    Chang, Y.7    Liu, Q.8    Sun, X.9    Wu, M.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.