Liver-specific knockdown of JNK1 up-regulates proliferator-activated receptor γ coactivator 1β and increases plasma triglyceride despite reduced glucose and insulin levels in diet-induced obese mice

Journal of Biological Chemistry

Volumn 282, Issue 31, 2007, Pages 22765-22774

  Yang, Ruojing ^a   Wilcox, Denise M ^a   Haasch, Deanna L ^a   Jung, Paul M ^a   Nguyen, Phong T ^a   Voorbach, Martin J ^a   Doktor, Stella ^a   Brodjian, Sevan ^a   Bush, Eugene N ^a   Lin, Emily ^a,b   Jacobson, Peer B ^a   Collins, Christine A ^a   Landschulz, Katherine T ^a,c   Trevillyan, James M ^a   Rondinone, Cristina M ^a,d   Surowy, Terry K ^a  

^a ABBOTT LABORATORIES   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c ELI LILLY AND COMPANY   (United States)

^d HOFFMANN LA ROCHE INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN RESISTANCE; JUN N-TERMINAL KINASES (JNK); TRIGLYCERIDE SYNTHESIS; TRIGLYCERIDES;

BIOLOGICAL ORGANS; GENE EXPRESSION; GLUCOSE; INSULIN; MEDICAL PROBLEMS; PLASMA (HUMAN); RNA; SYNTHESIS (CHEMICAL);

ENZYMES;

ADENOVIRUS VECTOR; GLUCOKINASE; GLUCOSE; INSULIN; MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1BETA; PROTEIN; PROTEIN KINASE B; SHORT HAIRPIN RNA; STRESS ACTIVATED PROTEIN KINASE 1; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIET; ENZYME PHOSPHORYLATION; ENZYME REGULATION; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; GLYCOLYSIS; IN VITRO STUDY; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; KNOCKOUT MOUSE; LIVER; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TISSUE SPECIFICITY; TRIACYLGLYCEROL BLOOD LEVEL; UPREGULATION;

ADENOVIRIDAE; ANIMAL FEED; ANIMALS; DNA PRIMERS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCOSE; INSULIN; LIVER; MICE; MICE, OBESE; MITOGEN-ACTIVATED PROTEIN KINASE 8; PHOSPHORYLATION; PPAR GAMMA; TRANS-ACTIVATORS; TRIGLYCERIDES;

ADENOVIRIDAE; MUS;

EID: 34547942526     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M700790200     Document Type: Article

References (33)

1. Wellen, K. E., and Hotamisligil, G. S. (2005) J. Clin. Invest. 115, 1111-1119
2. Manning, A. M., and Davis, R. J. (2003) Nat. Rev. Drug Discov. 2, 554-565
3. Bennett, B. L., Satoh, Y., and Lewis, A. J. (2003) Curr. Opin. Pharmacol. 3, 420-425
4. Hirosumi, J., Tuncman, G., Chang, L., Gorgun, C. Z., Uysal, K. T., Maeda, K., Karin, M., and Hotamisligil, G. S. (2002) Nature 420, 333-336
5. Davis, R. J. (2000) Cell 103, 239-252
6. Carlson, C. J., Koterski, S., Sciotti, R. J., Poccard, G. B., and Rondinone, C. M. (2003) Diabetes 52, 634-641
7. Aguirre, V., Uchida, T., Yenush, L., Davis, R., and White, M. F. (2000) J. Biol. Chem. 275, 9047-9054
8. Gao, Z., Zhang, X., Zuberi, A., Hwang, D., Quon, M. J., Lefevre, M., and Ye, J. (2004) Mol. Endocrinol. 18, 2024-2034
9. Ozcan, U., Cao, Q., Yilmaz, E., Lee, A. H., Iwakoshi, N. N., Ozdelen, E., Tuncman, G., Gorgun, C., Glimcher, L. H., and Hotamisligil, G. S. (2004) Science 306, 457-461
10. Novina, C. D., and Sharp, P. A. (2004) Nature 430, 161-164
11. Dorsett, Y., and Tuschl, T. (2004) Nat. Rev. Drug Discov. 3, 318-329
12. Becker, T. C., Noel, R. J., Coats, W. S., Gomez-Foix, A. M., Alam, T., Gerard, R. D., and Newgard, C. B. (1994) Methods Cell Biol. 43, 161-189
13. Lin, J., Yang, R., Tarr, P. T., Wu, P. H., Handschin, C., Li, S., Yang, W., Pei, L., Uldry, M., Tontonoz, P., Newgard, C. B., and Spiegelman, B. M. (2005) Cell 120, 261-273
14. Wolfrum, C., and Stoffel, M. (2006) Cell Metab. 3, 99-110
15. Huang, A., Chen, Y., Wang, X., Zhao, S., Su, N., and White, D. W. (2004) FEBS Lett. 558, 69-73
16. Yang, R., Cao, L., Gasa, R., Brady, M. J., Sherry, A. D., and Newgard, C. B. (2002) J. Biol. Chem. 277, 1514-1523
17. Yang, R., and Newgard, C. B. (2003) J. Biol. Chem. 278, 23418-23425
18. Maglott, D., Ostell, J., Pruitt, K. D., and Tatusova, T. (2005) Nucleic Acids Res. 33, D39-D45
19. Dahlquist, K. D., Salomonis, N., Vranizan, K., Lawlor, S. C., and Conklin, B. R. (2002) Nat. Genet. 31, 19-20
20. Doniger, S. W., Salomonis, N., Dahlquist, K. D., Vranizan, K., Lawlor, S. C., and Conklin, B. R. (2003) Genome Biology 4:R7
21. Wilcox, D. M., Yang, R., Morgan, S. J., Nguyen, P. T., Voorbach, M. J., Jung, P. M., Haasch, D. L., Lin, E., Bush, E. N., Opgenorth, T. J., Jacobson, P. B., Collins, C. A., Rondinone, C. M., Surowy, T., and Landschulz, K. T. (2007) J. RNAi Gene Silencing 3, 225-236
22. Foretz, M., Guichard, C., Ferre, P., and Foufelle, F. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 12737-12742
23. O'Doherty, R. M., Lehman, D. L., Telemaque-Potts, S., and Newgard, C. B. (1999) Diabetes 48, 2022-2027
24. Tietge, U. J., Bakillah, A., Maugeais, C., Tsukamoto, K., Hussain, M., and Rader, D. J. (1999) J. Lipid Res. 40, 2134-2139
25. Kaneto, H., Nakatani, Y., Miyatsuka, T., Kawamori, D., Matsuoka, T. A., Matsuhisa, M., Kajimoto, Y., Ichijo, H., Yamasaki, Y., and Hori, M. (2004) Nat. Med. 10, 1128-1132
26. Nakatani, Y., Kaneto, H., Kawamori, D., Hatazaki, M., Miyatsuka, T., Matsuoka, T. A., Kajimoto, Y., Matsuhisa, M., Yamasaki, Y., and Hori, M. (2004) J. Biol. Chem. 279, 45803-45809
27. Spann, N. J., Kang, S., Li, A. C., Chen, A. Z., Newberry, E. P., Davidson, N. O., Hui, S. T., and Davis, R. A. (2006) J. Biol. Chem. 281, 33066-33077
28. Ono, H., Shimano, H., Katagiri, H., Yahagi, N., Sakoda, H., Onishi, Y., Anai, M., Ogihara, T., Fujishiro, M., Viana, A. Y., Fukushima, Y., Abe, M., Shojima, N., Kikuchi, M., Yamada, N., Oka, Y., and Asano, T. (2003) Diabetes 52, 2905-2913
29. Fleischmann, M., and Iynedjian, P. B. (2000) Biochem. J. 349, 13-17
30. Matsumoto, M., Ogawa, W., Akimoto, K., Inoue, H., Miyake, K., Furukawa, K., Hayashi, Y., Iguchi, H., Matsuki, Y., Hiramatsu, R., Shimano, H., Yamada, N., Ohno, S., Kasuga, M., and Noda, T. (2003) J. Clin. Invest. 112, 935-944
31. Farese, R. V., Sajan, M. P., and Standaert, M. L. (2005) Exp. Biol. Med. 230, 593-605
32. Desai, U. J., Slosberg, E. D., Boettcher, B. R., Caplan, S. L., Fanelli, B., Stephan, Z., Gunther, V. J., Kaleko, M., and Connelly, S. (2001) Diabetes 50, 2287-2295
33. Grimsby, J., Sarabu, R., Corbett, W. L., Haynes, N. E., Bizzarro, F. T., Coffey, J. W., Guertin, K. R., Hilliard, D. W., Kester, R. F., Mahaney, P. E., Marcus, L., Qi, L., Spence, C. L., Tengi, J., Magnuson, M. A., Chu, C. A., Dvorozniak, M. T., Matschinsky, F. M., and Grippo, J. F. (2003) Science 301, 370-373