Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

Science

Volumn 283, Issue 5407, 1999, Pages 1544-1548

  Elchebly, Mounib ^a   Payette, Paul ^b   Michaliszyn, Eva ^a   Cromlish, Wanda ^b   Collins, Susan ^b   Loy, Ailsa Lee ^a   Normandin, Denis ^b   Cheng, Alan ^a   Himms Hagen, Jean ^c   Chan, Chi Chung ^b   Ramachandran, Chidambaram ^b   Gresser, Michael J ^b   Tremblay, Michel L ^a   Kennedy, Brian P ^b  

^a MCGILL UNIVERSITY   (Canada)

^b MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

^c UNIVERSITY OF OTTAWA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE 1B; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GENE DISRUPTION; GENE TARGETING; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; INSULIN TOLERANCE TEST; LIPID DIET; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; DIETARY FATS; GENE TARGETING; GLUCOSE TOLERANCE TEST; INSULIN; INSULIN RESISTANCE; LIVER; MALE; MICE; MICE, KNOCKOUT; MUSCLE, SKELETAL; OBESITY; PHOSPHOPROTEINS; PHOSPHORYLATION; PHOSPHOTYROSINE; PROTEIN-TYROSINE-PHOSPHATASE; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION;

ANIMALIA; RODENTIA;

EID: 0033525870     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.283.5407.1544     Document Type: Article

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13. 2-terminal peptide detected with enhanced chemiluminescence (NEN).
14. 2-terminal peptide detected with enhanced chemiluminescence (NEN).
15. 2-terminal peptide detected with enhanced chemiluminescence (NEN).
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22. P. Payette, M. Elchebly, M. L. Tremblay, B. P. Kennedy, unpublished data.
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29. We thank D. Moller, J. Mudgett, E. Asante-Appiah, and J. Evans for discussions. M.E. is a fellowship recipient and M.LT. is a Chercheur-Boursier Senior from the Fonds de la Recherche en Sante du Quebec. Supported in part by a grant from the Medical Research Council (MRC)/Pharmaceutical Manufacturers Association of Canada (M.L.T.) and the MRC (J.H.-H.).