-
1
-
-
0031851293
-
Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation
-
Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 1998; 15: 539-553
-
(1998)
Diabet Med
, vol.15
, pp. 539-553
-
-
Alberti, K.G.1
Zimmet, P.Z.2
-
2
-
-
0003725206
-
Definition, diagnosis and classification of diabetes melllitus and its complications
-
WHO Consultation, Part 1: diagnosis and classification of diabetes mellitus. Geneva: World Health Organisation, Geneva, Report No. 99.2. Available from: URL:,
-
WHO Consultation. Definition, diagnosis and classification of diabetes melllitus and its complications. Part 1: diagnosis and classification of diabetes mellitus. Geneva: World Health Organisation, Geneva; 1999. Report No. 99.2. Available from: URL: http://whqlibdoc.who.int/hq/1999/WHO_NCD_NCS_99.2.pdf
-
(1999)
-
-
-
4
-
-
84890757611
-
-
US Department of Health and Human Services, Public Health Service, National Institutes of Health, National Heart, Lung and Blood Institute. Third Report of the Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (ATP III Final Report). NIH Publication, : No. 01-3670
-
US Department of Health and Human Services, Public Health Service, National Institutes of Health, National Heart, Lung and Blood Institute. Third Report of the Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (ATP III Final Report). NIH Publication, 2001: No. 01-3670
-
(2001)
-
-
-
5
-
-
37849039167
-
-
The IDF consensus worldwide definition of the metabolic syndrome, Available from: URL
-
The IDF consensus worldwide definition of the metabolic syndrome. International Diabetes Federation. 2005. Available from: URL: http://www.idf.org/idf-worldwide-definitionmetabolic-syndrome
-
(2005)
International Diabetes Federation
-
-
-
6
-
-
84858342848
-
-
The IDF consensus worldwide definition of the metabolic syndrome, Diabetes Atlas, third edition, , Brussel, Available from: URL, Accessed March 2007
-
The IDF consensus worldwide definition of the metabolic syndrome. 2006. Diabetes Atlas, third edition. International Diabetes Federation 2006, Brussel. Available from: URL: http://www.idf.org/webdata/docs/MetS_def_update2006.pdf. Accessed March 2007
-
(2006)
International Diabetes Federation 2006
-
-
-
7
-
-
0032990860
-
Cortisol metabolism in human obesity: impaired cortisone > cortisol conversion in subjects with central adiposity
-
Stewart PM, Boulton A, Kumar S, Clark PM, Shackleton CH. Cortisol metabolism in human obesity: impaired cortisone > cortisol conversion in subjects with central adiposity. J Clin Endocrinol Metab 1999; 84: 1022-1027
-
(1999)
J Clin Endocrinol Metab
, vol.84
, pp. 1022-1027
-
-
Stewart, P.M.1
Boulton, A.2
Kumar, S.3
Clark, P.M.4
Shackleton, C.H.5
-
8
-
-
0023202481
-
Adrenalectomy and steroid treatment in obese (ob/ob) and diabetic (db/db) mice
-
Shimomura Y, Bray GA, Lee M. Adrenalectomy and steroid treatment in obese (ob/ob) and diabetic (db/db) mice. Horm Metab Res 1987; 19: 295-299
-
(1987)
Horm Metab Res
, vol.19
, pp. 295-299
-
-
Shimomura, Y.1
Bray, G.A.2
Lee, M.3
-
9
-
-
18844388999
-
Minireview: hexose- 6-phosphate dehydrogenase and redox control of 11{beta}- hydroxysteroid dehydrogenase type 1 activity
-
Hewitt KN, Walker EA, Stewart PM. Minireview: hexose- 6-phosphate dehydrogenase and redox control of 11{beta}- hydroxysteroid dehydrogenase type 1 activity. Endocrinology 2005; 146: 2539-2543
-
(2005)
Endocrinology
, vol.146
, pp. 2539-2543
-
-
Hewitt, K.N.1
Walker, E.A.2
Stewart, P.M.3
-
10
-
-
46549084919
-
Direct protein-protein interaction of 11beta-hydroxysteroid dehydrogenase type 1 and hexose- 6-phosphate dehydrogenase in the endoplasmic reticulum lumen
-
Atanasov AG, Nashev LG, Gelman L, Legeza B, Sack R, Portmann R, Odermatt A. Direct protein-protein interaction of 11beta-hydroxysteroid dehydrogenase type 1 and hexose- 6-phosphate dehydrogenase in the endoplasmic reticulum lumen. Biochim Biophys Acta 2008; 1783: 1536-1543
-
(2008)
Biochim Biophys Acta
, vol.1783
, pp. 1536-1543
-
-
Atanasov, A.G.1
Nashev, L.G.2
Gelman, L.3
Legeza, B.4
Sack, R.5
Portmann, R.6
Odermatt, A.7
-
11
-
-
3042595899
-
Cooperativity between 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase in the lumen of the endoplasmic reticulum
-
Bánhegyi G, Benedetti A, Fulceri R, Senesi S. Cooperativity between 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase in the lumen of the endoplasmic reticulum. J Biol Chem 2004; 279: 27017-27021
-
(2004)
J Biol Chem
, vol.279
, pp. 27017-27021
-
-
Bánhegyi, G.1
Benedetti, A.2
Fulceri, R.3
Senesi, S.4
-
12
-
-
0042667127
-
Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency
-
Draper N, Walker EA, Bujalska IJ, Tomlinson JW, Chalder SM, Arlt W, Lavery GG, Bedendo O, Ray DW, Laing I, Malunowicz E, White PC, Hewison M, Mason PJ, Connell JM, Shackleton CH, Stewart PM. Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency. Nat Genet 2003; 34: 434-439
-
(2003)
Nat Genet
, vol.34
, pp. 434-439
-
-
Draper, N.1
Walker, E.A.2
Bujalska, I.J.3
Tomlinson, J.W.4
Chalder, S.M.5
Arlt, W.6
Lavery, G.G.7
Bedendo, O.8
Ray, D.W.9
Laing, I.10
Malunowicz, E.11
White, P.C.12
Hewison, M.13
Mason, P.J.14
Connell, J.M.15
Shackleton, C.H.16
Stewart, P.M.17
-
13
-
-
33645994443
-
Uncoupled redox systems in the lumen of the endoplasmic reticulum. Pyridine nucleotides stay reduced in an oxidative environment
-
Piccirella S, Czegle I, Lizák B, Margittai E, Senesi S, PappE, Csala M, Fulceri R, Csermely P, Mandl J, Benedetti A, Bánhegyi G. Uncoupled redox systems in the lumen of the endoplasmic reticulum. Pyridine nucleotides stay reduced in an oxidative environment. J Biol Chem 2006; 281: 4671-4677
-
(2006)
J Biol Chem
, vol.281
, pp. 4671-4677
-
-
Piccirella, S.1
Czegle, I.2
Lizák, B.3
Margittai, E.4
Senesi, S.5
Papp, E.6
Csala, M.7
Fulceri, R.8
Csermely, P.9
Mandl, J.10
Benedetti, A.11
Bánhegyi, G.12
-
14
-
-
33644906113
-
Cooperativity between 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase is based on a common pyridine nucleotide pool in the lumen of the endoplasmic reticulum
-
Czegle I, Piccirella S, Senesi S, Csala M, Mandl J, Bánhegyi G, Fulceri R, Benedetti A. Cooperativity between 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase is based on a common pyridine nucleotide pool in the lumen of the endoplasmic reticulum. Mol Cell Endocrinol 2006; 248: 24-25
-
(2006)
Mol Cell Endocrinol
, vol.248
, pp. 24-25
-
-
Czegle, I.1
Piccirella, S.2
Senesi, S.3
Csala, M.4
Mandl, J.5
Bánhegyi, G.6
Fulceri, R.7
Benedetti, A.8
-
15
-
-
67449161934
-
Hexose-6-phosphate dehydrogenase: linking endocrinology and metabolism in the endoplasmic reticulum
-
Bánhegyi G, Csala M, Benedetti A. Hexose-6-phosphate dehydrogenase: linking endocrinology and metabolism in the endoplasmic reticulum. J Mol Endocrinol 2009; 42: 283-289
-
(2009)
J Mol Endocrinol
, vol.42
, pp. 283-289
-
-
Bánhegyi, G.1
Csala, M.2
Benedetti, A.3
-
16
-
-
65249133510
-
Endoplasmic reticulum: nutrient sensor in physiology and pathology
-
Mandl J, Mészáros T, Bánhegyi G, Hunyady L, Csala M. Endoplasmic reticulum: nutrient sensor in physiology and pathology. Trends Endocrinol Metab 2009; 20: 194-201
-
(2009)
Trends Endocrinol Metab
, vol.20
, pp. 194-201
-
-
Mandl, J.1
Mészáros, T.2
Bánhegyi, G.3
Hunyady, L.4
Csala, M.5
-
17
-
-
0037443499
-
Inhibition of microsomal glucose-6-phosphate transport in human neutrophils results in apoptosis: a potential explanation for neutrophil dysfunction in glycogen storage disease type 1b
-
Leuzzi R, Bánhegyi G, Kardon T, Marcolongo P, Capecchi PL, Burger HJ, Benedetti A, Fulceri R. Inhibition of microsomal glucose-6-phosphate transport in human neutrophils results in apoptosis: a potential explanation for neutrophil dysfunction in glycogen storage disease type 1b. Blood 2003; 101: 2381-2387
-
(2003)
Blood
, vol.101
, pp. 2381-2387
-
-
Leuzzi, R.1
Bánhegyi, G.2
Kardon, T.3
Marcolongo, P.4
Capecchi, P.L.5
Burger, H.J.6
Benedetti, A.7
Fulceri, R.8
-
18
-
-
33745167272
-
Silencing of the human microsomal glucose-6-phosphate translocase induces glioma cell death: potential new anticancer target for curcumin
-
Belkaid A, Copland IB, Massillon D, Annabi B. Silencing of the human microsomal glucose-6-phosphate translocase induces glioma cell death: potential new anticancer target for curcumin. FEBS Lett 2006; 580: 3746-3752
-
(2006)
FEBS Lett
, vol.580
, pp. 3746-3752
-
-
Belkaid, A.1
Copland, I.B.2
Massillon, D.3
Annabi, B.4
-
19
-
-
44649127360
-
Maintenance of luminal NADPH in the endoplasmic reticulum promotes the survival of human neutrophil granulocytes
-
Kardon T, Senesi S, Marcolongo P, Legeza B, Bánhegyi G, Mandl J, Fulceri R, Benedetti A. Maintenance of luminal NADPH in the endoplasmic reticulum promotes the survival of human neutrophil granulocytes. FEBS Lett 2008; 582: 1809-1815
-
(2008)
FEBS Lett
, vol.582
, pp. 1809-1815
-
-
Kardon, T.1
Senesi, S.2
Marcolongo, P.3
Legeza, B.4
Bánhegyi, G.5
Mandl, J.6
Fulceri, R.7
Benedetti, A.8
-
20
-
-
43749114512
-
Deletion of hexose-6-phosphate dehydrogenase activates the unfolded protein response pathway and induces skeletal myopathy
-
Lavery GG, Walker EA, Turan N, Rogoff D, Ryder JW, Shelton JM, Richardson JA, Falciani F, White PC, Stewart PM, Parker KL, McMillan DR. Deletion of hexose-6-phosphate dehydrogenase activates the unfolded protein response pathway and induces skeletal myopathy. J Biol Chem 2008; 283: 8453-8461
-
(2008)
J Biol Chem
, vol.283
, pp. 8453-8461
-
-
Lavery, G.G.1
Walker, E.A.2
Turan, N.3
Rogoff, D.4
Ryder, J.W.5
Shelton, J.M.6
Richardson, J.A.7
Falciani, F.8
White, P.C.9
Stewart, P.M.10
Parker, K.L.11
McMillan, D.R.12
-
21
-
-
34249814328
-
The glucose- 6-phosphate transporter-hexose-6-phosphate dehydrogenase- 11beta-hydroxysteroid dehydrogenase type 1 system of the adipose tissue
-
Marcolongo P, Piccirella S, Senesi S, Wunderlich L, Gerin I, Mandl J, Fulceri R, Bánhegyi G, Benedetti A. The glucose- 6-phosphate transporter-hexose-6-phosphate dehydrogenase- 11beta-hydroxysteroid dehydrogenase type 1 system of the adipose tissue. Endocrinology 2007; 148: 2487-2495
-
(2007)
Endocrinology
, vol.148
, pp. 2487-2495
-
-
Marcolongo, P.1
Piccirella, S.2
Senesi, S.3
Wunderlich, L.4
Gerin, I.5
Mandl, J.6
Fulceri, R.7
Bánhegyi, G.8
Benedetti, A.9
-
22
-
-
0034969823
-
Cortisol metabolism and the role of 11beta-hydroxysteroid dehydrogenase
-
Tomlinson JW, Stewart PM. Cortisol metabolism and the role of 11beta-hydroxysteroid dehydrogenase. Best Pract Res Clin Endocrinol Metab 2001; 15: 61-78
-
(2001)
Best Pract Res Clin Endocrinol Metab
, vol.15
, pp. 61-78
-
-
Tomlinson, J.W.1
Stewart, P.M.2
-
23
-
-
0031053553
-
Immunodetection of 11 beta-hydroxysteroid dehydrogenase type 2 in human mineralocorticoid target tissues: evidence for nuclear localization
-
Shimojo M, Ricketts ML, Petrelli MD, Moradi P, Johnson GD, Bradwell AR, Hewison M, Howie AJ, Stewart PM. Immunodetection of 11 beta-hydroxysteroid dehydrogenase type 2 in human mineralocorticoid target tissues: evidence for nuclear localization. Endocrinology 1997; 138: 1305-1311
-
(1997)
Endocrinology
, vol.138
, pp. 1305-1311
-
-
Shimojo, M.1
Ricketts, M.L.2
Petrelli, M.D.3
Moradi, P.4
Johnson, G.D.5
Bradwell, A.R.6
Hewison, M.7
Howie, A.J.8
Stewart, P.M.9
-
24
-
-
0141739647
-
Tissue-specific Cushing's syndrome, 11beta-hydroxysteroid dehydrogenases and the redefinition of corticosteroid hormone action
-
Stewart PM. Tissue-specific Cushing's syndrome, 11beta-hydroxysteroid dehydrogenases and the redefinition of corticosteroid hormone action. Eur J Endocrinol 2003; 149: 163-168
-
(2003)
Eur J Endocrinol
, vol.149
, pp. 163-168
-
-
Stewart, P.M.1
-
25
-
-
63249128191
-
Liver is the site of splanchnic cortisol production in obese nondiabetic humans
-
Basu R, Basu A, Grudzien M, Jung P, Jacobson P, Johnson M, Singh R, Sarr M, Rizza RA. Liver is the site of splanchnic cortisol production in obese nondiabetic humans. Diabetes 2009; 58: 39-45
-
(2009)
Diabetes
, vol.58
, pp. 39-45
-
-
Basu, R.1
Basu, A.2
Grudzien, M.3
Jung, P.4
Jacobson, P.5
Johnson, M.6
Singh, R.7
Sarr, M.8
Rizza, R.A.9
-
26
-
-
0030936556
-
Does central obesity reflect "Cushing's disease of the omentum"?
-
Bujalska IJ, Kumar S, Stewart PM. Does central obesity reflect "Cushing's disease of the omentum"? Lancet 1997; 349: 1210-1213
-
(1997)
Lancet
, vol.349
, pp. 1210-1213
-
-
Bujalska, I.J.1
Kumar, S.2
Stewart, P.M.3
-
27
-
-
0033305631
-
Differentiation of adipose stromal cells: the roles of glucocorticoids and 11beta-hydroxysteroid dehydrogenase
-
Bujalska IJ, Kumar S, Hewison M, Stewart PM. Differentiation of adipose stromal cells: the roles of glucocorticoids and 11beta-hydroxysteroid dehydrogenase. Endocrinology 1999; 140: 3188-3196
-
(1999)
Endocrinology
, vol.140
, pp. 3188-3196
-
-
Bujalska, I.J.1
Kumar, S.2
Hewison, M.3
Stewart, P.M.4
-
28
-
-
0036959901
-
A switch in dehydrogenase to reductase activity of 11 beta-hydroxysteroid dehydrogenase type 1 upon differentiation of human omental adipose stromal cells
-
Bujalska IJ, Walker EA, Hewison M, Stewart PM. A switch in dehydrogenase to reductase activity of 11 beta-hydroxysteroid dehydrogenase type 1 upon differentiation of human omental adipose stromal cells. J Clin Endocrinol Metab 2002; 87: 1205-1210
-
(2002)
J Clin Endocrinol Metab
, vol.87
, pp. 1205-1210
-
-
Bujalska, I.J.1
Walker, E.A.2
Hewison, M.3
Stewart, P.M.4
-
29
-
-
39349102358
-
Hexose-6- phosphate dehydrogenase modulates 11beta-hydroxysteroid dehydrogenase type 1-dependent metabolism of 7-keto- and 7beta-hydroxy-neurosteroids
-
Nashev LG, Chandsawangbhuwana C, Balazs Z, Atanasov AG, Dick B, Frey FJ, Baker ME, Odermatt A. Hexose-6- phosphate dehydrogenase modulates 11beta-hydroxysteroid dehydrogenase type 1-dependent metabolism of 7-keto- and 7beta-hydroxy-neurosteroids. PLoS One 2007; 2: e561
-
(2007)
PLoS One
, vol.2
-
-
Nashev, L.G.1
Chandsawangbhuwana, C.2
Balazs, Z.3
Atanasov, A.G.4
Dick, B.5
Frey, F.J.6
Baker, M.E.7
Odermatt, A.8
-
30
-
-
18844438379
-
Hexose-6-phosphate dehydrogenase confers oxo-reductase activity upon 11 beta-hydroxysteroid dehydrogenase type 1
-
Bujalska IJ, Draper N, Michailidou Z, Tomlinson JW, White PC, Chapman KE, Walker EA, Stewart PM. Hexose-6-phosphate dehydrogenase confers oxo-reductase activity upon 11 beta-hydroxysteroid dehydrogenase type 1. J Mol Endocrinol 2005; 34: 675-684
-
(2005)
J Mol Endocrinol
, vol.34
, pp. 675-684
-
-
Bujalska, I.J.1
Draper, N.2
Michailidou, Z.3
Tomlinson, J.W.4
White, P.C.5
Chapman, K.E.6
Walker, E.A.7
Stewart, P.M.8
-
31
-
-
0024440502
-
Promoting effect of glucocorticoids on the differentiation of human adipocyte precursor cells cultured in a chemically defined medium
-
Hauner H, Entenmann G, Wabitsch M, Gaillard D, Ailhaud G, Negrel R, Pfeiffer EF. Promoting effect of glucocorticoids on the differentiation of human adipocyte precursor cells cultured in a chemically defined medium. J Clin Invest 1989; 84: 1663-1670
-
(1989)
J Clin Invest
, vol.84
, pp. 1663-1670
-
-
Hauner, H.1
Entenmann, G.2
Wabitsch, M.3
Gaillard, D.4
Ailhaud, G.5
Negrel, R.6
Pfeiffer, E.F.7
-
32
-
-
3342998410
-
Hexose-6-phosphate dehydrogenase determines the reaction direction of 11beta-hydroxysteroid dehydrogenase type 1 as an oxoreductase
-
Atanasov AG, Nashev LG, Schweizer RA, Frick C, Odermatt A. Hexose-6-phosphate dehydrogenase determines the reaction direction of 11beta-hydroxysteroid dehydrogenase type 1 as an oxoreductase. FEBS Lett 2004; 571: 129-133
-
(2004)
FEBS Lett
, vol.571
, pp. 129-133
-
-
Atanasov, A.G.1
Nashev, L.G.2
Schweizer, R.A.3
Frick, C.4
Odermatt, A.5
-
33
-
-
0035824440
-
A transgenic model of visceral obesity and the metabolic syndrome
-
Masuzaki H, Paterson J, Shinyama H, Morton NM, Mullins JJ, Seckl JR, Flier JS. A transgenic model of visceral obesity and the metabolic syndrome. Science 2001; 294: 2166-2170
-
(2001)
Science
, vol.294
, pp. 2166-2170
-
-
Masuzaki, H.1
Paterson, J.2
Shinyama, H.3
Morton, N.M.4
Mullins, J.J.5
Seckl, J.R.6
Flier, J.S.7
-
34
-
-
0031595976
-
11Beta-hydroxysteroid dehydrogenase 1 in adipocytes: expression is differentiation-dependent and hormonally regulated
-
Napolitano A, Voice MW, Edwards CR, Seckl JR, Chapman KE. 11Beta-hydroxysteroid dehydrogenase 1 in adipocytes: expression is differentiation-dependent and hormonally regulated. J Steroid Biochem Mol Biol 1998; 64: 251-260
-
(1998)
J Steroid Biochem Mol Biol
, vol.64
, pp. 251-260
-
-
Napolitano, A.1
Voice, M.W.2
Edwards, C.R.3
Seckl, J.R.4
Chapman, K.E.5
-
35
-
-
0037121073
-
Expression profiling during adipocyte differentiation of 3T3- L1 fibroblasts
-
Jessen BA, Stevens GJ. Expression profiling during adipocyte differentiation of 3T3- L1 fibroblasts. Gene 2002; 299: 95-100
-
(2002)
Gene
, vol.299
, pp. 95-100
-
-
Jessen, B.A.1
Stevens, G.J.2
-
36
-
-
55749111677
-
Constant expression of hexose-6-phosphate dehydrogenase during differentiation of human adipose-derived mesenchymal stem cells
-
Senesi S, Marcolongo P, Manini I, Fulceri R, Sorrentino V, Csala M, Bánhegyi G, Benedetti A. Constant expression of hexose-6-phosphate dehydrogenase during differentiation of human adipose-derived mesenchymal stem cells. J Mol Endocrinol 2008; 41: 125-133
-
(2008)
J Mol Endocrinol
, vol.41
, pp. 125-133
-
-
Senesi, S.1
Marcolongo, P.2
Manini, I.3
Fulceri, R.4
Sorrentino, V.5
Csala, M.6
Bánhegyi, G.7
Benedetti, A.8
-
37
-
-
43849110089
-
Glucocorticoids and fatty acid metabolism in humans: fuelling fat redistribution in the metabolic syndrome
-
Macfarlane DP, Forbes S, Walker BR. Glucocorticoids and fatty acid metabolism in humans: fuelling fat redistribution in the metabolic syndrome. J Endocrinol 2008; 197: 189-204
-
(2008)
J Endocrinol
, vol.197
, pp. 189-204
-
-
Macfarlane, D.P.1
Forbes, S.2
Walker, B.R.3
-
38
-
-
0031965002
-
Regulation of 11 beta-hydroxysteroid dehydrogenase type 1 in primary cultures of rat and human hepatocytes
-
Ricketts ML, Shoesmith KJ, Hewison M, Strain A, Eggo MC, Stewart PM. Regulation of 11 beta-hydroxysteroid dehydrogenase type 1 in primary cultures of rat and human hepatocytes. J Endocrinol 1998; 156: 159-168
-
(1998)
J Endocrinol
, vol.156
, pp. 159-168
-
-
Ricketts, M.L.1
Shoesmith, K.J.2
Hewison, M.3
Strain, A.4
Eggo, M.C.5
Stewart, P.M.6
-
39
-
-
0028973283
-
11 betahydroxysteroid dehydrogenase is an exclusive 11 betareductase in primary cultures of rat hepatocytes: effect of physicochemical and hormonal manipulations
-
Jamieson PM, Chapman KE, Edwards CR, Seckl JR. 11 betahydroxysteroid dehydrogenase is an exclusive 11 betareductase in primary cultures of rat hepatocytes: effect of physicochemical and hormonal manipulations. Endocrinology 1995; 136: 4754-4761
-
(1995)
Endocrinology
, vol.136
, pp. 4754-4761
-
-
Jamieson, P.M.1
Chapman, K.E.2
Edwards, C.R.3
Seckl, J.R.4
-
40
-
-
0034083523
-
11 beta-hydroxysteroid dehydrogenase type 1 is a predominant 11 beta-reductase in the intact perfused rat liver
-
Jamieson PM, Walker BR, Chapman KE, Andrew R, Rossiter S, Seckl JR. 11 beta-hydroxysteroid dehydrogenase type 1 is a predominant 11 beta-reductase in the intact perfused rat liver. J Endocrinol 2000; 165: 685-692
-
(2000)
J Endocrinol
, vol.165
, pp. 685-692
-
-
Jamieson, P.M.1
Walker, B.R.2
Chapman, K.E.3
Andrew, R.4
Rossiter, S.5
Seckl, J.R.6
-
41
-
-
0031283178
-
11beta-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress
-
Kotelevtsev Y, Holmes MC, Burchell A, Houston PM, Schmoll D, Jamieson P, Best R, Brown R, Edwards CR, Seckl JR, Mullins JJ. 11beta-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress. Proc Natl Acad Sci U S A 1997; 94: 14924-14929
-
(1997)
Proc Natl Acad Sci U S A
, vol.94
, pp. 14924-14929
-
-
Kotelevtsev, Y.1
Holmes, M.C.2
Burchell, A.3
Houston, P.M.4
Schmoll, D.5
Jamieson, P.6
Best, R.7
Brown, R.8
Edwards, C.R.9
Seckl, J.R.10
Mullins, J.J.11
-
42
-
-
0035111323
-
Intracellular regeneration of glucocorticoids by 11betahydroxysteroid dehydrogenase (11beta-HSD)- 1 plays a key role in regulation of the hypothalamic-pituitary-adrenal axis: analysis of 11beta-HSD-1-deficient mice
-
Harris HJ, Kotelevtsev Y, Mullins JJ, Seckl JR, Holmes MC. Intracellular regeneration of glucocorticoids by 11betahydroxysteroid dehydrogenase (11beta-HSD)- 1 plays a key role in regulation of the hypothalamic-pituitary-adrenal axis: analysis of 11beta-HSD-1-deficient mice. Endocrinology 2001; 142: 114-120
-
(2001)
Endocrinology
, vol.142
, pp. 114-120
-
-
Harris, H.J.1
Kotelevtsev, Y.2
Mullins, J.J.3
Seckl, J.R.4
Holmes, M.C.5
-
43
-
-
0036432995
-
Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 decreases blood glucose concentrations in hyperglycaemic mice
-
Alberts P, Engblom L, Edling N, Forsgren M, Klingström G, Larsson C, Rönquist-Nii Y, Ohman B, Abrahmsén L. Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 decreases blood glucose concentrations in hyperglycaemic mice. Diabetologia 2002; 45: 1528-1532
-
(2002)
Diabetologia
, vol.45
, pp. 1528-1532
-
-
Alberts, P.1
Engblom, L.2
Edling, N.3
Forsgren, M.4
Klingström, G.5
Larsson, C.6
Rönquist-Nii, Y.7
Ohman, B.8
Abrahmsén, L.9
-
44
-
-
0242468543
-
Selective inhibition of 11 beta-hydroxysteroid dehydrogenase type 1 improves hepatic insulin sensitivity in hyperglycemic mice strains
-
Alberts P, Nilsson C, Selen G, Engblom LO, Edling NH, Norling S, Klingström G, Larsson C, Forsgren M, Ashkzari M, Nilsson CE, Fiedler M, Bergqvist E, Ohman B, Björkstrand E, Abrahmsen LB. Selective inhibition of 11 beta-hydroxysteroid dehydrogenase type 1 improves hepatic insulin sensitivity in hyperglycemic mice strains. Endocrinology 2003; 144: 4755-4762
-
(2003)
Endocrinology
, vol.144
, pp. 4755-4762
-
-
Alberts, P.1
Nilsson, C.2
Selen, G.3
Engblom, L.O.4
Edling, N.H.5
Norling, S.6
Klingström, G.7
Larsson, C.8
Forsgren, M.9
Ashkzari, M.10
Nilsson, C.E.11
Fiedler, M.12
Bergqvist, E.13
Ohman, B.14
Björkstrand, E.15
Abrahmsen, L.B.16
-
45
-
-
85047693986
-
Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice
-
Masuzaki H, Yamamoto H, Kenyon CJ, Elmquist JK, Morton NM, Paterson JM, Shinyama H, Sharp MG, Fleming S, Mullins JJ, Seckl JR, Flier JS. Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice. J Clin Invest 2003; 112: 83-90
-
(2003)
J Clin Invest
, vol.112
, pp. 83-90
-
-
Masuzaki, H.1
Yamamoto, H.2
Kenyon, C.J.3
Elmquist, J.K.4
Morton, N.M.5
Paterson, J.M.6
Shinyama, H.7
Sharp, M.G.8
Fleming, S.9
Mullins, J.J.10
Seckl, J.R.11
Flier, J.S.12
-
46
-
-
0034519393
-
Mechanisms of dysregulation of 11 beta-hydroxysteroid dehydrogenase type 1 in obese Zucker rats
-
Livingstone DE, Kenyon CJ, Walker BR. Mechanisms of dysregulation of 11 beta-hydroxysteroid dehydrogenase type 1 in obese Zucker rats. J Endocrinol 2000; 167: 533-539
-
(2000)
J Endocrinol
, vol.167
, pp. 533-539
-
-
Livingstone, D.E.1
Kenyon, C.J.2
Walker, B.R.3
-
47
-
-
0038336755
-
Obese Zucker rats have reduced mineralocorticoid receptor and 11beta-hydroxysteroid dehydrogenase type 1 expression in hippocampus-implications for dysregulation of the hypothalamic-pituitary-adrenal axis in obesity
-
Mattsson C, Lai M, Noble J, McKinney E, Yau JL, Seckl JR, Walker BR. Obese Zucker rats have reduced mineralocorticoid receptor and 11beta-hydroxysteroid dehydrogenase type 1 expression in hippocampus-implications for dysregulation of the hypothalamic-pituitary-adrenal axis in obesity. Endocrinology 2003; 144: 2997-3003
-
(2003)
Endocrinology
, vol.144
, pp. 2997-3003
-
-
Mattsson, C.1
Lai, M.2
Noble, J.3
McKinney, E.4
Yau, J.L.5
Seckl, J.R.6
Walker, B.R.7
-
48
-
-
0037645827
-
Leptin activation of corticosterone production in hepatocytes may contribute to the reversal of obesity and hyperglycemia in leptin-deficient ob/ob mice
-
Liu Y, Nakagawa Y, Wang Y, Li R, Li X, Ohzeki T, Friedman TC. Leptin activation of corticosterone production in hepatocytes may contribute to the reversal of obesity and hyperglycemia in leptin-deficient ob/ob mice. Diabetes 2003; 52: 1409-1416
-
(2003)
Diabetes
, vol.52
, pp. 1409-1416
-
-
Liu, Y.1
Nakagawa, Y.2
Wang, Y.3
Li, R.4
Li, X.5
Ohzeki, T.6
Friedman, T.C.7
-
49
-
-
12144250997
-
Increased glucocorticoid receptor and 11{beta}-hydroxysteroid dehydrogenase type 1 expression in hepatocytes may contribute to the phenotype of type 2 diabetes in db/db mice
-
Liu Y, Nakagawa Y, Wang Y, Sakurai R, Tripathi PV, Lutfy K, Friedman TC. Increased glucocorticoid receptor and 11{beta}-hydroxysteroid dehydrogenase type 1 expression in hepatocytes may contribute to the phenotype of type 2 diabetes in db/db mice. Diabetes 2005; 54: 32-40
-
(2005)
Diabetes
, vol.54
, pp. 32-40
-
-
Liu, Y.1
Nakagawa, Y.2
Wang, Y.3
Sakurai, R.4
Tripathi, P.V.5
Lutfy, K.6
Friedman, T.C.7
-
50
-
-
33644679335
-
A polygenic model of the metabolic syndrome with reduced circulating and intraadipose glucocorticoid action
-
Morton NM, Densmore V, Wamil M, Ramage L, Nichol K, Bünger L, Seckl JR, Kenyon CJ. A polygenic model of the metabolic syndrome with reduced circulating and intraadipose glucocorticoid action. Diabetes 2005; 54: 3371-3378
-
(2005)
Diabetes
, vol.54
, pp. 3371-3378
-
-
Morton, N.M.1
Densmore, V.2
Wamil, M.3
Ramage, L.4
Nichol, K.5
Bünger, L.6
Seckl, J.R.7
Kenyon, C.J.8
-
52
-
-
35148876079
-
11beta- HSD1 inhibition improves triglyceridemia through reduced liver VLDL secretion and partitions lipids toward oxidative tissues
-
Berthiaume M, Laplante M, Festuccia WT, Cianflone K, Turcotte LP, Joanisse DR, Olivecrona G, Thieringer R, Deshaies Y. 11beta- HSD1 inhibition improves triglyceridemia through reduced liver VLDL secretion and partitions lipids toward oxidative tissues. Am J Physiol Endocrinol Metab 2007; 293: E1045-E1052
-
(2007)
Am J Physiol Endocrinol Metab
, vol.293
-
-
Berthiaume, M.1
Laplante, M.2
Festuccia, W.T.3
Cianflone, K.4
Turcotte, L.P.5
Joanisse, D.R.6
Olivecrona, G.7
Thieringer, R.8
Deshaies, Y.9
-
53
-
-
37149046570
-
Carbenoxolone treatment attenuates symptoms of metabolic syndrome and atherogenesis in obese, hyperlipidemic mice
-
Nuotio-Antar AM, Hachey DL, Hasty AH. Carbenoxolone treatment attenuates symptoms of metabolic syndrome and atherogenesis in obese, hyperlipidemic mice. Am J Physiol Endocrinol Metab 2007; 293: E1517-E1528
-
(2007)
Am J Physiol Endocrinol Metab
, vol.293
-
-
Nuotio-Antar, A.M.1
Hachey, D.L.2
Hasty, A.H.3
-
54
-
-
34447105433
-
Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 as a promising therapeutic target
-
Wamil M, Seckl JR. Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 as a promising therapeutic target. Drug Discov Today 2007; 12: 504-520
-
(2007)
Drug Discov Today
, vol.12
, pp. 504-520
-
-
Wamil, M.1
Seckl, J.R.2
-
55
-
-
0036324073
-
Tissue-specific changes in peripheral cortisol metabolism in obese women: increased adipose 11beta-hydroxysteroid dehydrogenase type 1 activity
-
Rask E, Walker BR, Söderberg S, Livingstone DE, Eliasson M, Johnson O, Andrew R, Olsson T. Tissue-specific changes in peripheral cortisol metabolism in obese women: increased adipose 11beta-hydroxysteroid dehydrogenase type 1 activity. J Clin Endocrinol Metab 2002; 87: 3330-3336
-
(2002)
J Clin Endocrinol Metab
, vol.87
, pp. 3330-3336
-
-
Rask, E.1
Walker, B.R.2
Söderberg, S.3
Livingstone, D.E.4
Eliasson, M.5
Johnson, O.6
Andrew, R.7
Olsson, T.8
-
56
-
-
0031784958
-
Obesity and gender influence cortisol secretion and metabolism in man
-
Andrew R, Phillips DI, Walker BR. Obesity and gender influence cortisol secretion and metabolism in man. J Clin Endocrinol Metab 1998; 83: 1806-1809
-
(1998)
J Clin Endocrinol Metab
, vol.83
, pp. 1806-1809
-
-
Andrew, R.1
Phillips, D.I.2
Walker, B.R.3
-
57
-
-
0037240926
-
11 beta-Hydroxysteroid dehydrogenase activity in hypothalamic obesity
-
Tiosano D, Eisentein I, Militianu D, Chrousos GP, Hochberg Z. 11 beta-Hydroxysteroid dehydrogenase activity in hypothalamic obesity. J Clin Endocrinol Metab 2003; 88: 379-384
-
(2003)
J Clin Endocrinol Metab
, vol.88
, pp. 379-384
-
-
Tiosano, D.1
Eisentein, I.2
Militianu, D.3
Chrousos, G.P.4
Hochberg, Z.5
-
58
-
-
0035051205
-
Tissue-specific dysregulation of cortisol metabolism in human obesity
-
Rask E, Olsson T, Söderberg S, Andrew R, Livingstone DE, Johnson O, Walker BR. Tissue-specific dysregulation of cortisol metabolism in human obesity. J Clin Endocrinol Metab 2001; 86: 1418-1421
-
(2001)
J Clin Endocrinol Metab
, vol.86
, pp. 1418-1421
-
-
Rask, E.1
Olsson, T.2
Söderberg, S.3
Andrew, R.4
Livingstone, D.E.5
Johnson, O.6
Walker, B.R.7
-
59
-
-
0033018598
-
Cortisol effects on body mass, blood pressure, and cholesterol in the general population
-
Fraser R, Ingram MC, Anderson NH, Morrison C, Davies E, Connell JM. Cortisol effects on body mass, blood pressure, and cholesterol in the general population. Hypertension 1999; 33: 1364-1368
-
(1999)
Hypertension
, vol.33
, pp. 1364-1368
-
-
Fraser, R.1
Ingram, M.C.2
Anderson, N.H.3
Morrison, C.4
Davies, E.5
Connell, J.M.6
-
60
-
-
0033832411
-
Urinary cortisol to cortisone metabolites in hypertensive obese children
-
Csábi GY, Juricskay S, Molnár D. Urinary cortisol to cortisone metabolites in hypertensive obese children. J Endocrinol Invest 2000; 23: 435-439
-
(2000)
J Endocrinol Invest
, vol.23
, pp. 435-439
-
-
Csábi, G.Y.1
Juricskay, S.2
Molnár, D.3
-
61
-
-
0035145867
-
Altered control of cortisol secretion in adult men with low birth weight and cardiovascular risk factors
-
Reynolds RM, Walker BR, Syddall HE, Andrew R, Wood PJ, Whorwood CB, Phillips DI. Altered control of cortisol secretion in adult men with low birth weight and cardiovascular risk factors. J Clin Endocrinol Metab 2001; 86: 245-250
-
(2001)
J Clin Endocrinol Metab
, vol.86
, pp. 245-250
-
-
Reynolds, R.M.1
Walker, B.R.2
Syddall, H.E.3
Andrew, R.4
Wood, P.J.5
Whorwood, C.B.6
Phillips, D.I.7
-
62
-
-
33644690146
-
Increased cortisol bioavailability, abdominal obesity, and the metabolic syndrome in obese women
-
Duclos M, Marquez Pereira P, Barat P, Gatta B, Roger P. Increased cortisol bioavailability, abdominal obesity, and the metabolic syndrome in obese women. Obes Res 2005; 13: 1157-1166
-
(2005)
Obes Res
, vol.13
, pp. 1157-1166
-
-
Duclos, M.1
Marquez Pereira, P.2
Barat, P.3
Gatta, B.4
Roger, P.5
-
63
-
-
70350574080
-
Obesity is accompanied by disturbances in peripheral glucocorticoid metabolism and changes in FA recycling
-
Simonyte K, Rask E, Näslund I, Angelhed JE, Lönn L, Olsson T, Mattsson C. Obesity is accompanied by disturbances in peripheral glucocorticoid metabolism and changes in FA recycling. Obesity (Silver Spring) 2009; 17: 1982-1987
-
(2009)
Obesity (Silver Spring)
, vol.17
, pp. 1982-1987
-
-
Simonyte, K.1
Rask, E.2
Näslund, I.3
Angelhed, J.E.4
Lönn, L.5
Olsson, T.6
Mattsson, C.7
-
64
-
-
4544263736
-
11beta-hydroxysteroid dehydrogenase type 1 activity in lean and obese males with type 2 diabetes mellitus
-
Valsamakis G, Anwar A, Tomlinson JW, Shackleton CH, McTernan PG, Chetty R, Wood PJ, Banerjee AK, Holder G, Barnett AH, Stewart PM, Kumar S. 11beta-hydroxysteroid dehydrogenase type 1 activity in lean and obese males with type 2 diabetes mellitus. J Clin Endocrinol Metab 2004; 89: 4755-4761
-
(2004)
J Clin Endocrinol Metab
, vol.89
, pp. 4755-4761
-
-
Valsamakis, G.1
Anwar, A.2
Tomlinson, J.W.3
Shackleton, C.H.4
McTernan, P.G.5
Chetty, R.6
Wood, P.J.7
Banerjee, A.K.8
Holder, G.9
Barnett, A.H.10
Stewart, P.M.11
Kumar, S.12
-
65
-
-
0028172907
-
'Liver-type' 11 beta-hydroxysteroid dehydrogenase cDNA encodes reductase but not dehydrogenase activity in intact mammalian COS- 7 cells
-
Low SC, Chapman KE, Edwards CR, Seckl JR. 'Liver-type' 11 beta-hydroxysteroid dehydrogenase cDNA encodes reductase but not dehydrogenase activity in intact mammalian COS- 7 cells. J Mol Endocrinol 1994; 13: 167-174
-
(1994)
J Mol Endocrinol
, vol.13
, pp. 167-174
-
-
Low, S.C.1
Chapman, K.E.2
Edwards, C.R.3
Seckl, J.R.4
-
66
-
-
0027972092
-
Sexual dimorphism of hepatic 11 beta-hydroxysteroid dehydrogenase in the rat: the role of growth hormone patterns
-
Low SC, Chapman KE, Edwards CR, Wells T, Robinson IC, Seckl JR. Sexual dimorphism of hepatic 11 beta-hydroxysteroid dehydrogenase in the rat: the role of growth hormone patterns. J Endocrinol 1994; 143: 541-548
-
(1994)
J Endocrinol
, vol.143
, pp. 541-548
-
-
Low, S.C.1
Chapman, K.E.2
Edwards, C.R.3
Wells, T.4
Robinson, I.C.5
Seckl, J.R.6
-
67
-
-
0030037837
-
11 beta-hydroxysteroid dehydrogenase type 1 expression in 2S FAZA hepatoma cells is hormonally regulated: a model system for the study of hepatic glucocorticoid metabolism
-
Voice MW, Seckl JR, Edwards CR, Chapman KE. 11 beta-hydroxysteroid dehydrogenase type 1 expression in 2S FAZA hepatoma cells is hormonally regulated: a model system for the study of hepatic glucocorticoid metabolism. Biochem J 1996; 317 (Pt 2): 621-625
-
(1996)
Biochem J
, vol.317
, Issue.PART 2
, pp. 621-625
-
-
Voice, M.W.1
Seckl, J.R.2
Edwards, C.R.3
Chapman, K.E.4
-
68
-
-
39849090597
-
Is the metabolic syndrome an intracellular Cushing state? Effects of multiple humoral factors on the transcriptional activity of the hepatic glucocorticoid-activating enzyme (11betahydroxysteroid dehydrogenase type 1) gene
-
Iwasaki Y, Takayasu S, Nishiyama M, Tsugita M, Taguchi T, Asai M, Yoshida M, Kambayashi M, Hashimoto K. Is the metabolic syndrome an intracellular Cushing state? Effects of multiple humoral factors on the transcriptional activity of the hepatic glucocorticoid-activating enzyme (11betahydroxysteroid dehydrogenase type 1) gene. Mol Cell Endocrinol 2008; 285: 10-18
-
(2008)
Mol Cell Endocrinol
, vol.285
, pp. 10-18
-
-
Iwasaki, Y.1
Takayasu, S.2
Nishiyama, M.3
Tsugita, M.4
Taguchi, T.5
Asai, M.6
Yoshida, M.7
Kambayashi, M.8
Hashimoto, K.9
-
69
-
-
60849139081
-
Tumor necrosis factor-alpha upregulates 11beta-hydroxysteroid dehydrogenase type 1 expression by CCAAT/enhancer binding protein-beta in HepG2 cells
-
Ignatova ID, Kostadinova RM, Goldring CE, Nawrocki AR, Frey FJ, Frey BM. Tumor necrosis factor-alpha upregulates 11beta-hydroxysteroid dehydrogenase type 1 expression by CCAAT/enhancer binding protein-beta in HepG2 cells. Am J Physiol Endocrinol Metab 2009; 296: E367-E377
-
(2009)
Am J Physiol Endocrinol Metab
, vol.296
-
-
Ignatova, I.D.1
Kostadinova, R.M.2
Goldring, C.E.3
Nawrocki, A.R.4
Frey, F.J.5
Frey, B.M.6
-
70
-
-
0034730762
-
C/EBP regulates hepatic transcription of 11beta -hydroxysteroid dehydrogenase type 1. A novel mechanism for cross-talk between the C/EBP and glucocorticoid signaling pathways
-
Williams LJ, Lyons V, MacLeod I, Rajan V, Darlington GJ, Poli V, Seckl JR, Chapman KE. C/EBP regulates hepatic transcription of 11beta -hydroxysteroid dehydrogenase type 1. A novel mechanism for cross-talk between the C/EBP and glucocorticoid signaling pathways. J Biol Chem 2000; 275: 30232-30239
-
(2000)
J Biol Chem
, vol.275
, pp. 30232-30239
-
-
Williams, L.J.1
Lyons, V.2
MacLeod, I.3
Rajan, V.4
Darlington, G.J.5
Poli, V.6
Seckl, J.R.7
Chapman, K.E.8
-
71
-
-
0027515493
-
Tissue specific effects of thyroid hormone on 11 beta-hydroxysteroid dehydrogenase gene expression
-
Whorwood CB, Sheppard MC, Stewart PM. Tissue specific effects of thyroid hormone on 11 beta-hydroxysteroid dehydrogenase gene expression. J Steroid Biochem Mol Biol 1993; 46: 539-547
-
(1993)
J Steroid Biochem Mol Biol
, vol.46
, pp. 539-547
-
-
Whorwood, C.B.1
Sheppard, M.C.2
Stewart, P.M.3
-
72
-
-
0020561197
-
Influence of thyroid function on the in vivo cortisol in equilibrium cortisone equilibrium in man
-
Zumoff B, Bradlow HL, Levin J, Fukushima DK. Influence of thyroid function on the in vivo cortisol in equilibrium cortisone equilibrium in man. J Steroid Biochem 1983; 18: 437-440
-
(1983)
J Steroid Biochem
, vol.18
, pp. 437-440
-
-
Zumoff, B.1
Bradlow, H.L.2
Levin, J.3
Fukushima, D.K.4
-
73
-
-
0030661601
-
Metyrapone is a competitive inhibitor of 11beta-hydroxysteroid dehydrogenase type 1 reductase
-
Sampath-Kumar R, Yu M, Khalil MW, Yang K. Metyrapone is a competitive inhibitor of 11beta-hydroxysteroid dehydrogenase type 1 reductase. J Steroid Biochem Mol Biol 1997; 62: 195-199
-
(1997)
J Steroid Biochem Mol Biol
, vol.62
, pp. 195-199
-
-
Sampath-Kumar, R.1
Yu, M.2
Khalil, M.W.3
Yang, K.4
-
74
-
-
0027461539
-
11 beta-Hydroxysteroid dehydrogenase deficiency and glucocorticoid status in patients with alcoholic and nonalcoholic chronic liver disease
-
Stewart PM, Burra P, Shackleton CH, Sheppard MC, Elias E. 11 beta-Hydroxysteroid dehydrogenase deficiency and glucocorticoid status in patients with alcoholic and nonalcoholic chronic liver disease. J Clin Endocrinol Metab 1993; 76: 748-751
-
(1993)
J Clin Endocrinol Metab
, vol.76
, pp. 748-751
-
-
Stewart, P.M.1
Burra, P.2
Shackleton, C.H.3
Sheppard, M.C.4
Elias, E.5
-
75
-
-
14644388141
-
Increased in vivo regeneration of cortisol in adipose tissue in human obesity and effects of the 11beta-hydroxysteroid dehydrogenase type 1 inhibitor carbenoxolone
-
Sandeep TC, Andrew R, Homer NZ, Andrews RC, Smith K, Walker BR. Increased in vivo regeneration of cortisol in adipose tissue in human obesity and effects of the 11beta-hydroxysteroid dehydrogenase type 1 inhibitor carbenoxolone. Diabetes 2005; 54: 872-879
-
(2005)
Diabetes
, vol.54
, pp. 872-879
-
-
Sandeep, T.C.1
Andrew, R.2
Homer, N.Z.3
Andrews, R.C.4
Smith, K.5
Walker, B.R.6
-
76
-
-
0037374775
-
Is 11beta-hydroxysteroid dehydrogenase type 1 a therapeutic target? Effects of carbenoxolone in lean and obese Zucker rats
-
Livingstone DE, Walker BR. Is 11beta-hydroxysteroid dehydrogenase type 1 a therapeutic target? Effects of carbenoxolone in lean and obese Zucker rats. J Pharmacol Exp Ther 2003; 305: 167-172
-
(2003)
J Pharmacol Exp Ther
, vol.305
, pp. 167-172
-
-
Livingstone, D.E.1
Walker, B.R.2
-
77
-
-
0028839840
-
Carbenoxolone increases hepatic insulin sensitivity in man: a novel role for 11-oxosteroid reductase in enhancing glucocorticoid receptor activation
-
Walker BR, Connacher AA, Lindsay RM, Webb DJ, Edwards CR. Carbenoxolone increases hepatic insulin sensitivity in man: a novel role for 11-oxosteroid reductase in enhancing glucocorticoid receptor activation. J Clin Endocrinol Metab 1995; 80: 3155-3159
-
(1995)
J Clin Endocrinol Metab
, vol.80
, pp. 3155-3159
-
-
Walker, B.R.1
Connacher, A.A.2
Lindsay, R.M.3
Webb, D.J.4
Edwards, C.R.5
-
78
-
-
33947491197
-
Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 activity in vivo limits glucocorticoid exposure to human adipose tissue and decreases lipolysis
-
Tomlinson JW, Sherlock M, Hughes B, Hughes SV, Kilvington F, Bartlett W, Courtney R, Rejto P, Carley W, Stewart PM. Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 activity in vivo limits glucocorticoid exposure to human adipose tissue and decreases lipolysis. J Clin Endocrinol Metab 2007; 92: 857-864
-
(2007)
J Clin Endocrinol Metab
, vol.92
, pp. 857-864
-
-
Tomlinson, J.W.1
Sherlock, M.2
Hughes, B.3
Hughes, S.V.4
Kilvington, F.5
Bartlett, W.6
Courtney, R.7
Rejto, P.8
Carley, W.9
Stewart, P.M.10
-
79
-
-
23944493717
-
11beta- HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice
-
Hermanowski-Vosatka A, Balkovec JM, Cheng K, Chen HY, Hernandez M, Koo GC, Le Grand CB, Li Z, Metzger JM, Mundt SS, Noonan H, Nunes CN, Olson SH, Pikounis B, Ren N, Robertson N, Schaeffer JM, Shah K, Springer MS, Strack AM, Strowski M, Wu K, Wu T, Xiao J, Zhang BB, Wright SD, Thieringer R. 11beta- HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice. J Exp Med 2005; 202: 517-527
-
(2005)
J Exp Med
, vol.202
, pp. 517-527
-
-
Hermanowski-Vosatka, A.1
Balkovec, J.M.2
Cheng, K.3
Chen, H.Y.4
Hernandez, M.5
Koo, G.C.6
Le Grand, C.B.7
Li, Z.8
Metzger, J.M.9
Mundt, S.S.10
Noonan, H.11
Nunes, C.N.12
Olson, S.H.13
Pikounis, B.14
Ren, N.15
Robertson, N.16
Schaeffer, J.M.17
Shah, K.18
Springer, M.S.19
Strack, A.M.20
Strowski, M.21
Wu, K.22
Wu, T.23
Xiao, J.24
Zhang, B.B.25
Wright, S.D.26
Thieringer, R.27
more..
-
80
-
-
0037194658
-
Arylsulfonamidothiazoles as a new class of potential antidiabetic drugs
-
Barf T, Vallgårda J, Emond R, Häggström C, Kurz G, Nygren A, Larwood V, Mosialou E, Axelsson K, Olsson R, Engblom L, Edling N, Rönquist-Nii Y, Ohman B, Alberts P, Abrahmsén L. Arylsulfonamidothiazoles as a new class of potential antidiabetic drugs. Discovery of potent and selective inhibitors of the 11beta-hydroxysteroid dehydrogenase type 1. J Med Chem 2002; 45: 3813-3815
-
(2002)
Discovery of potent and selective inhibitors of the 11beta-hydroxysteroid dehydrogenase type 1. J Med Chem
, vol.45
, pp. 3813-3815
-
-
Barf, T.1
Vallgårda, J.2
Emond, R.3
Häggström, C.4
Kurz, G.5
Nygren, A.6
Larwood, V.7
Mosialou, E.8
Axelsson, K.9
Olsson, R.10
Engblom, L.11
Edling, N.12
Rönquist-Nii, Y.13
Ohman, B.14
Alberts, P.15
Abrahmsén, L.16
-
81
-
-
37149016719
-
Sucrose access differentially modifies 11beta-hydroxysteroid dehydrogenase- 1 and hexose-6-phosphate dehydrogenase message in liver and adipose tissue in rats
-
London E, Lala G, Berger R, Panzenbeck A, Kohli AA, Renner M, Jackson A, Raynor T, Loya K, Castonguay TW. Sucrose access differentially modifies 11beta-hydroxysteroid dehydrogenase- 1 and hexose-6-phosphate dehydrogenase message in liver and adipose tissue in rats. J Nutr 2007; 137: 2616-2621
-
(2007)
J Nutr
, vol.137
, pp. 2616-2621
-
-
London, E.1
Lala, G.2
Berger, R.3
Panzenbeck, A.4
Kohli, A.A.5
Renner, M.6
Jackson, A.7
Raynor, T.8
Loya, K.9
Castonguay, T.W.10
-
82
-
-
33646007919
-
Hexose- 6-phosphate dehydrogenase knock-out mice lack 11 beta-hydroxysteroid dehydrogenase type 1-mediated glucocorticoid generation
-
Lavery GG, Walker EA, Draper N, Jeyasuria P, Marcos J, Shackleton CH, Parker KL, White PC, Stewart PM. Hexose- 6-phosphate dehydrogenase knock-out mice lack 11 beta-hydroxysteroid dehydrogenase type 1-mediated glucocorticoid generation. J Biol Chem 2006; 281: 6546-6551
-
(2006)
J Biol Chem
, vol.281
, pp. 6546-6551
-
-
Lavery, G.G.1
Walker, E.A.2
Draper, N.3
Jeyasuria, P.4
Marcos, J.5
Shackleton, C.H.6
Parker, K.L.7
White, P.C.8
Stewart, P.M.9
-
83
-
-
34748824878
-
Abnormalities of glucose homeostasis and the hypothalamic-pituitary-adrenal axis in mice lacking hexose-6-phosphate dehydrogenase
-
Rogoff D, Ryder JW, Black K, Yan Z, Burgess SC, McMillan DR, White PC. Abnormalities of glucose homeostasis and the hypothalamic-pituitary-adrenal axis in mice lacking hexose-6-phosphate dehydrogenase. Endocrinology 2007; 148: 5072-5080
-
(2007)
Endocrinology
, vol.148
, pp. 5072-5080
-
-
Rogoff, D.1
Ryder, J.W.2
Black, K.3
Yan, Z.4
Burgess, S.C.5
McMillan, D.R.6
White, P.C.7
-
84
-
-
36349033013
-
Hypoglycemia with enhanced hepatic glycogen synthesis in recombinant mice lacking hexose-6-phosphate dehydrogenase
-
Lavery GG, Hauton D, Hewitt KN, Brice SM, Sherlock M, Walker EA, Stewart PM. Hypoglycemia with enhanced hepatic glycogen synthesis in recombinant mice lacking hexose-6-phosphate dehydrogenase. Endocrinology 2007; 148: 6100-6106
-
(2007)
Endocrinology
, vol.148
, pp. 6100-6106
-
-
Lavery, G.G.1
Hauton, D.2
Hewitt, K.N.3
Brice, S.M.4
Sherlock, M.5
Walker, E.A.6
Stewart, P.M.7
-
85
-
-
34848854245
-
11beta-Hydroxysteroid Dehydrogenase Type 1 Regulation by Intracellular Glucose 6-Phosphate Provides Evidence for a Novel Link between Glucose Metabolism and Hypothalamo-Pituitary-Adrenal Axis Function
-
Walker EA, Ahmed A, Lavery GG, Tomlinson JW, Kim SY, Cooper MS, Ride JP, Hughes BA, Shackleton CH, McKiernan P, Elias E, Chou JY, Stewart PM. 11beta-Hydroxysteroid Dehydrogenase Type 1 Regulation by Intracellular Glucose 6-Phosphate Provides Evidence for a Novel Link between Glucose Metabolism and Hypothalamo-Pituitary-Adrenal Axis Function. J Biol Chem 2007; 282: 27030-27036
-
(2007)
J Biol Chem
, vol.282
, pp. 27030-27036
-
-
Walker, E.A.1
Ahmed, A.2
Lavery, G.G.3
Tomlinson, J.W.4
Kim, S.Y.5
Cooper, M.S.6
Ride, J.P.7
Hughes, B.A.8
Shackleton, C.H.9
McKiernan, P.10
Elias, E.11
Chou, J.Y.12
Stewart, P.M.13
|