메뉴 건너뛰기




Volumn 123, Issue , 2015, Pages 51-60

Role of physical exercise on hepatic insulin, glucocorticoid and inflammatory signaling pathways in an animal model of non-alcoholic steatohepatitis

Author keywords

Endurance training; Glucocorticoid signaling; High fat diet; Inflammation; Insulin signaling; Non alcoholic steatohepatitis; Voluntary physical activity

Indexed keywords

GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; INSULIN; INTERLEUKIN 6; LEUKEMIA INHIBITORY FACTOR; OXIDOREDUCTASE; SIRTUIN 1; STRESS ACTIVATED PROTEIN KINASE; TRANSFORMING GROWTH FACTOR BETA; AUTACOID; PRIMER DNA;

EID: 84921665807     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2014.12.013     Document Type: Article
Times cited : (20)

References (69)
  • 1
    • 79959517565 scopus 로고    scopus 로고
    • Human fatty liver disease: Old questions and new insights
    • J.C. Cohen, J.D. Horton, and H.H. Hobbs Human fatty liver disease: old questions and new insights Science 332 2011 1519 1523
    • (2011) Science , vol.332 , pp. 1519-1523
    • Cohen, J.C.1    Horton, J.D.2    Hobbs, H.H.3
  • 2
    • 84880419922 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis: Pathogenesis and novel therapeutic approaches
    • D. Schuppan, and J.M. Schattenberg Non-alcoholic steatohepatitis: pathogenesis and novel therapeutic approaches J. Gastroenterol. Hepatol. 28 Suppl. 1 2013 68 76
    • (2013) J. Gastroenterol. Hepatol. , vol.28 , pp. 68-76
    • Schuppan, D.1    Schattenberg, J.M.2
  • 3
    • 84857403547 scopus 로고    scopus 로고
    • A switch in hepatic cortisol metabolism across the spectrum of non alcoholic fatty liver disease
    • A. Ahmed, E. Rabbitt, and T. Brady A switch in hepatic cortisol metabolism across the spectrum of non alcoholic fatty liver disease PLoS One 7 2012 e29531
    • (2012) PLoS One , vol.7 , pp. e29531
    • Ahmed, A.1    Rabbitt, E.2    Brady, T.3
  • 4
    • 84893636304 scopus 로고    scopus 로고
    • Transforming growth factor beta signaling in hepatocytes participates in steatohepatitis through regulation of cell death and lipid metabolism in mice
    • L. Yang, Y.S. Roh, and J. Song Transforming growth factor beta signaling in hepatocytes participates in steatohepatitis through regulation of cell death and lipid metabolism in mice Hepatology 59 2014 483 495
    • (2014) Hepatology , vol.59 , pp. 483-495
    • Yang, L.1    Roh, Y.S.2    Song, J.3
  • 5
    • 0037153158 scopus 로고    scopus 로고
    • A central role for JNK in obesity and insulin resistance
    • J. Hirosumi, G. Tuncman, and L. Chang A central role for JNK in obesity and insulin resistance Nature 420 2002 333 336
    • (2002) Nature , vol.420 , pp. 333-336
    • Hirosumi, J.1    Tuncman, G.2    Chang, L.3
  • 6
    • 14644427890 scopus 로고    scopus 로고
    • Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB
    • D. Cai, M. Yuan, and D.F. Frantz Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB Nat. Med. 11 2005 183 190
    • (2005) Nat. Med. , vol.11 , pp. 183-190
    • Cai, D.1    Yuan, M.2    Frantz, D.F.3
  • 7
    • 84865975344 scopus 로고    scopus 로고
    • 11beta-Hydroxysteroid dehydrogenase type 1: Relevance of its modulation in the pathophysiology of obesity, the metabolic syndrome and type 2 diabetes mellitus
    • C.D. Pereira, I. Azevedo, R. Monteiro, and M.J. Martins 11beta-Hydroxysteroid dehydrogenase type 1: relevance of its modulation in the pathophysiology of obesity, the metabolic syndrome and type 2 diabetes mellitus Diabetes Obes. Metab. 14 2012 869 881
    • (2012) Diabetes Obes. Metab. , vol.14 , pp. 869-881
    • Pereira, C.D.1    Azevedo, I.2    Monteiro, R.3    Martins, M.J.4
  • 8
    • 79959933148 scopus 로고    scopus 로고
    • Protection from obesity and diabetes by blockade of TGF-beta/Smad3 signaling
    • H. Yadav, C. Quijano, and A.K. Kamaraju Protection from obesity and diabetes by blockade of TGF-beta/Smad3 signaling Cell Metab. 14 2011 67 79
    • (2011) Cell Metab. , vol.14 , pp. 67-79
    • Yadav, H.1    Quijano, C.2    Kamaraju, A.K.3
  • 9
    • 14544271905 scopus 로고    scopus 로고
    • Positive and negative regulation of insulin signaling through IRS-1 phosphorylation
    • P. Gual, Y. Le Marchand-Brustel, and J.F. Tanti Positive and negative regulation of insulin signaling through IRS-1 phosphorylation Biochimie 87 2005 99 109
    • (2005) Biochimie , vol.87 , pp. 99-109
    • Gual, P.1    Le Marchand-Brustel, Y.2    Tanti, J.F.3
  • 10
    • 84874247282 scopus 로고    scopus 로고
    • Implication of inflammatory signaling pathways in obesity-induced insulin resistance
    • J.F. Tanti, F. Ceppo, J. Jager, and F. Berthou Implication of inflammatory signaling pathways in obesity-induced insulin resistance Front. Endocrinol. (Lausanne) 3 2012 181
    • (2012) Front. Endocrinol. (Lausanne) , vol.3 , pp. 181
    • Tanti, J.F.1    Ceppo, F.2    Jager, J.3    Berthou, F.4
  • 11
    • 84862784655 scopus 로고    scopus 로고
    • Endothelial nuclear factor kappaB in obesity and aging: Is endothelial nuclear factor kappaB a master regulator of inflammation and insulin resistance?
    • J.K. Kim Endothelial nuclear factor kappaB in obesity and aging: is endothelial nuclear factor kappaB a master regulator of inflammation and insulin resistance? Circulation 125 2012 1081 1083
    • (2012) Circulation , vol.125 , pp. 1081-1083
    • Kim, J.K.1
  • 12
    • 69249213467 scopus 로고    scopus 로고
    • Hepatic insulin resistance, metabolic syndrome and cardiovascular disease
    • R. Meshkani, and K. Adeli Hepatic insulin resistance, metabolic syndrome and cardiovascular disease Clin. Biochem. 42 2009 1331 1346
    • (2009) Clin. Biochem. , vol.42 , pp. 1331-1346
    • Meshkani, R.1    Adeli, K.2
  • 13
    • 15744403722 scopus 로고    scopus 로고
    • The use of protein tyrosine phosphatase 1B and insulin receptor immunostains to differentiate nonalcoholic from alcoholic steatohepatitis in liver biopsy specimens
    • S.O. Sanderson, and T.C. Smyrk The use of protein tyrosine phosphatase 1B and insulin receptor immunostains to differentiate nonalcoholic from alcoholic steatohepatitis in liver biopsy specimens Am. J. Clin. Pathol. 123 2005 503 509
    • (2005) Am. J. Clin. Pathol. , vol.123 , pp. 503-509
    • Sanderson, S.O.1    Smyrk, T.C.2
  • 14
    • 47249148827 scopus 로고    scopus 로고
    • Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo
    • J.M. Zabolotny, Y.B. Kim, and L.A. Welsh Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo J. Biol. Chem. 283 2008 14230 14241
    • (2008) J. Biol. Chem. , vol.283 , pp. 14230-14241
    • Zabolotny, J.M.1    Kim, Y.B.2    Welsh, L.A.3
  • 15
    • 0033525870 scopus 로고    scopus 로고
    • Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene
    • M. Elchebly, P. Payette, and E. Michaliszyn Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene Science 283 1999 1544 1548
    • (1999) Science , vol.283 , pp. 1544-1548
    • Elchebly, M.1    Payette, P.2    Michaliszyn, E.3
  • 16
    • 17644424349 scopus 로고    scopus 로고
    • Liver-specific protein-tyrosine phosphatase 1B (PTP1B) re-expression alters glucose homeostasis of PTP1B -/- mice
    • F.G. Haj, J.M. Zabolotny, Y.B. Kim, B.B. Kahn, and B.G. Neel Liver-specific protein-tyrosine phosphatase 1B (PTP1B) re-expression alters glucose homeostasis of PTP1B -/- mice J. Biol. Chem. 280 2005 15038 15046
    • (2005) J. Biol. Chem. , vol.280 , pp. 15038-15046
    • Haj, F.G.1    Zabolotny, J.M.2    Kim, Y.B.3    Kahn, B.B.4    Neel, B.G.5
  • 17
    • 80051679863 scopus 로고    scopus 로고
    • Hepatic PTP1B deficiency: The promise of a treatment for metabolic syndrome?
    • K.K. Bence Hepatic PTP1B deficiency: the promise of a treatment for metabolic syndrome? J. Clin. Metab. Diabetes 1 2010 27 33
    • (2010) J. Clin. Metab. Diabetes , vol.1 , pp. 27-33
    • Bence, K.K.1
  • 19
    • 36348975290 scopus 로고    scopus 로고
    • SIRT1 is involved in glucocorticoid-mediated control of uncoupling protein-3 gene transcription
    • R. Amat, G. Solanes, M. Giralt, and F. Villarroya SIRT1 is involved in glucocorticoid-mediated control of uncoupling protein-3 gene transcription J. Biol. Chem. 282 2007 34066 34076
    • (2007) J. Biol. Chem. , vol.282 , pp. 34066-34076
    • Amat, R.1    Solanes, G.2    Giralt, M.3    Villarroya, F.4
  • 20
    • 84884530630 scopus 로고    scopus 로고
    • Metabolic control through glucocorticoid hormones: An update
    • A.J. Rose, and S. Herzig Metabolic control through glucocorticoid hormones: an update Mol. Cell. Endocrinol. 380 2013 65 78
    • (2013) Mol. Cell. Endocrinol. , vol.380 , pp. 65-78
    • Rose, A.J.1    Herzig, S.2
  • 21
    • 34547885436 scopus 로고    scopus 로고
    • Glucocorticoids, metabolism and metabolic diseases
    • A. Vegiopoulos, and S. Herzig Glucocorticoids, metabolism and metabolic diseases Mol. Cell. Endocrinol. 275 2007 43 61
    • (2007) Mol. Cell. Endocrinol. , vol.275 , pp. 43-61
    • Vegiopoulos, A.1    Herzig, S.2
  • 22
    • 0027489828 scopus 로고
    • Modulation of insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of dexamethasone-treated rats
    • M.J. Saad, F. Folli, J.A. Kahn, and C.R. Kahn Modulation of insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of dexamethasone-treated rats J. Clin. Invest. 92 1993 2065 2072
    • (1993) J. Clin. Invest. , vol.92 , pp. 2065-2072
    • Saad, M.J.1    Folli, F.2    Kahn, J.A.3    Kahn, C.R.4
  • 23
    • 33749627688 scopus 로고    scopus 로고
    • Increased expression of Ob-Rb and its relationship with the overexpression of TGF-beta1 and the stage of fibrosis in patients with nonalcoholic steatohepatitis
    • A. Cayon, J. Crespo, M. Mayorga, A. Guerra, and F. Pons-Romero Increased expression of Ob-Rb and its relationship with the overexpression of TGF-beta1 and the stage of fibrosis in patients with nonalcoholic steatohepatitis Liver Int. 26 2006 1065 1071
    • (2006) Liver Int. , vol.26 , pp. 1065-1071
    • Cayon, A.1    Crespo, J.2    Mayorga, M.3    Guerra, A.4    Pons-Romero, F.5
  • 24
    • 84894269846 scopus 로고    scopus 로고
    • Differential effects of high-fish oil and high-lard diets on cells and cytokines involved in the inflammatory process in rat insulin-sensitive tissues
    • L. Lionetti, M.P. Mollica, and R. Sica Differential effects of high-fish oil and high-lard diets on cells and cytokines involved in the inflammatory process in rat insulin-sensitive tissues Int. J. Mol. Sci. 15 2014 3040 3063
    • (2014) Int. J. Mol. Sci. , vol.15 , pp. 3040-3063
    • Lionetti, L.1    Mollica, M.P.2    Sica, R.3
  • 25
    • 47149097985 scopus 로고    scopus 로고
    • Tranilast, an antifibrogenic agent, ameliorates a dietary rat model of nonalcoholic steatohepatitis
    • M. Uno, S. Kurita, and H. Misu Tranilast, an antifibrogenic agent, ameliorates a dietary rat model of nonalcoholic steatohepatitis Hepatology 48 2008 109 118
    • (2008) Hepatology , vol.48 , pp. 109-118
    • Uno, M.1    Kurita, S.2    Misu, H.3
  • 26
    • 84864283300 scopus 로고    scopus 로고
    • Muscles, exercise and obesity: Skeletal muscle as a secretory organ
    • B.K. Pedersen, and M.A. Febbraio Muscles, exercise and obesity: skeletal muscle as a secretory organ Nat. Rev. Endocrinol. 2012
    • (2012) Nat. Rev. Endocrinol.
    • Pedersen, B.K.1    Febbraio, M.A.2
  • 27
    • 84877003841 scopus 로고    scopus 로고
    • Life style modification improves insulin resistance and liver histology in patients with non-alcoholic fatty liver disease
    • G. Bhat, C.S. Baba, A. Pandey, N. Kumari, and G. Choudhuri Life style modification improves insulin resistance and liver histology in patients with non-alcoholic fatty liver disease World J. Hepatol. 4 2012 209 217
    • (2012) World J. Hepatol. , vol.4 , pp. 209-217
    • Bhat, G.1    Baba, C.S.2    Pandey, A.3    Kumari, N.4    Choudhuri, G.5
  • 28
    • 80053902834 scopus 로고    scopus 로고
    • Endurance exercise training ameliorates insulin resistance and reticulum stress in adipose and hepatic tissue in obese rats
    • G. da Luz, M.J. Frederico, and S. da Silva Endurance exercise training ameliorates insulin resistance and reticulum stress in adipose and hepatic tissue in obese rats Eur. J. Appl. Physiol. 111 2011 2015 2023
    • (2011) Eur. J. Appl. Physiol. , vol.111 , pp. 2015-2023
    • Da Luz, G.1    Frederico, M.J.2    Da Silva, S.3
  • 29
    • 84901410247 scopus 로고    scopus 로고
    • Regular exercise coupled to diet regimen accelerates reduction of hepatic steatosis and associated pathological conditions in nonalcoholic fatty liver disease
    • S. Oh, K. Tanaka, and T. Tsujimoto Regular exercise coupled to diet regimen accelerates reduction of hepatic steatosis and associated pathological conditions in nonalcoholic fatty liver disease Metab. Syndr. Relat. Disord. 2014
    • (2014) Metab. Syndr. Relat. Disord.
    • Oh, S.1    Tanaka, K.2    Tsujimoto, T.3
  • 30
    • 84988913690 scopus 로고    scopus 로고
    • Physical exercise antagonizes clinical and anatomical features characterizing Lieber-DeCarli diet-induced obesity and related metabolic disorders
    • I.O. Goncalves, E. Passos, and S. Rocha-Rodrigues Physical exercise antagonizes clinical and anatomical features characterizing Lieber-DeCarli diet-induced obesity and related metabolic disorders Clin. Nutr. 2014
    • (2014) Clin. Nutr.
    • Goncalves, I.O.1    Passos, E.2    Rocha-Rodrigues, S.3
  • 32
    • 57049134614 scopus 로고    scopus 로고
    • Validation of simple indexes to assess insulin sensitivity during pregnancy in Wistar and Sprague-Dawley rats
    • J. Cacho, J. Sevillano, J. de Castro, E. Herrera, and M.P. Ramos Validation of simple indexes to assess insulin sensitivity during pregnancy in Wistar and Sprague-Dawley rats Am. J. Physiol. Endocrinol. Metab. 295 2008 E1269 E1276
    • (2008) Am. J. Physiol. Endocrinol. Metab. , vol.295 , pp. E1269-E1276
    • Cacho, J.1    Sevillano, J.2    De Castro, J.3    Herrera, E.4    Ramos, M.P.5
  • 33
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • M.M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal. Biochem. 72 1976 248 254
    • (1976) Anal. Biochem. , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 34
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • U.K. Laemmli Cleavage of structural proteins during the assembly of the head of bacteriophage T4 Nature 227 1970 680 685
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 35
    • 0025275890 scopus 로고
    • Exercising mammals synthesize stress proteins
    • M. Locke, E.G. Noble, and B.G. Atkinson Exercising mammals synthesize stress proteins Am. J. Physiol. 258 1990 C723 C729
    • (1990) Am. J. Physiol. , vol.258 , pp. C723-C729
    • Locke, M.1    Noble, E.G.2    Atkinson, B.G.3
  • 36
    • 84863873773 scopus 로고    scopus 로고
    • Exercise training attenuates hepatic inflammation, fibrosis and macrophage infiltration during diet induced-obesity in mice
    • N. Kawanishi, H. Yano, and T. Mizokami Exercise training attenuates hepatic inflammation, fibrosis and macrophage infiltration during diet induced-obesity in mice Brain Behav. Immun. 26 2012 931 941
    • (2012) Brain Behav. Immun. , vol.26 , pp. 931-941
    • Kawanishi, N.1    Yano, H.2    Mizokami, T.3
  • 37
    • 79952361224 scopus 로고    scopus 로고
    • Physical activity recommendations, exercise intensity, and histological severity of nonalcoholic fatty liver disease
    • quiz 469
    • K.D. Kistler, E.M. Brunt, and J.M. Clark Physical activity recommendations, exercise intensity, and histological severity of nonalcoholic fatty liver disease Am. J. Gastroenterol. 106 2011 460 468 quiz 469
    • (2011) Am. J. Gastroenterol. , vol.106 , pp. 460-468
    • Kistler, K.D.1    Brunt, E.M.2    Clark, J.M.3
  • 38
    • 20044374023 scopus 로고    scopus 로고
    • Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    • D.E. Kleiner, E.M. Brunt, and M. Van Natta Design and validation of a histological scoring system for nonalcoholic fatty liver disease Hepatology 41 2005 1313 1321
    • (2005) Hepatology , vol.41 , pp. 1313-1321
    • Kleiner, D.E.1    Brunt, E.M.2    Van Natta, M.3
  • 39
    • 84884540840 scopus 로고    scopus 로고
    • Piperine reverses high fat diet-induced hepatic steatosis and insulin resistance in mice
    • S. Choi, Y. Choi, S. Kim, J. Jang, and T. Park Piperine reverses high fat diet-induced hepatic steatosis and insulin resistance in mice Food Chem. 141 2013 3627 3635
    • (2013) Food Chem. , vol.141 , pp. 3627-3635
    • Choi, S.1    Choi, Y.2    Kim, S.3    Jang, J.4    Park, T.5
  • 40
    • 84866122780 scopus 로고    scopus 로고
    • Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2
    • K.D. Copps, and M.F. White Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2 Diabetologia 55 2012 2565 2582
    • (2012) Diabetologia , vol.55 , pp. 2565-2582
    • Copps, K.D.1    White, M.F.2
  • 41
    • 84893051766 scopus 로고    scopus 로고
    • Insulin signaling, resistance, and the metabolic syndrome: Insights from mouse models into disease mechanisms
    • S. Guo Insulin signaling, resistance, and the metabolic syndrome: insights from mouse models into disease mechanisms J. Endocrinol. 220 2014 T1 T23
    • (2014) J. Endocrinol. , vol.220 , pp. T1-T23
    • Guo, S.1
  • 42
    • 77955806634 scopus 로고    scopus 로고
    • JNK1 and IKKbeta: Molecular links between obesity and metabolic dysfunction
    • G. Solinas, and M. Karin JNK1 and IKKbeta: molecular links between obesity and metabolic dysfunction FASEB J. 24 2010 2596 2611
    • (2010) FASEB J. , vol.24 , pp. 2596-2611
    • Solinas, G.1    Karin, M.2
  • 43
    • 0034708832 scopus 로고    scopus 로고
    • The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)
    • V. Aguirre, T. Uchida, L. Yenush, R. Davis, and M.F. White The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307) J. Biol. Chem. 275 2000 9047 9054
    • (2000) J. Biol. Chem. , vol.275 , pp. 9047-9054
    • Aguirre, V.1    Uchida, T.2    Yenush, L.3    Davis, R.4    White, M.F.5
  • 44
    • 65649098029 scopus 로고    scopus 로고
    • Phosphorylation of IRS proteins, insulin action, and insulin resistance
    • S. Boura-Halfon, and Y. Zick Phosphorylation of IRS proteins, insulin action, and insulin resistance Am. J. Physiol. Endocrinol. Metab. 296 2009 E581 E591
    • (2009) Am. J. Physiol. Endocrinol. Metab. , vol.296 , pp. E581-E591
    • Boura-Halfon, S.1    Zick, Y.2
  • 45
    • 70449724835 scopus 로고    scopus 로고
    • Cellular mechanisms of insulin resistance: Role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation
    • J.F. Tanti, and J. Jager Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation Curr. Opin. Pharmacol. 9 2009 753 762
    • (2009) Curr. Opin. Pharmacol. , vol.9 , pp. 753-762
    • Tanti, J.F.1    Jager, J.2
  • 46
    • 70349619811 scopus 로고    scopus 로고
    • Increased basal level of Akt-dependent insulin signaling may be responsible for the development of insulin resistance
    • H.Y. Liu, T. Hong, and G.B. Wen Increased basal level of Akt-dependent insulin signaling may be responsible for the development of insulin resistance Am. J. Physiol. Endocrinol. Metab. 297 2009 E898 E906
    • (2009) Am. J. Physiol. Endocrinol. Metab. , vol.297 , pp. E898-E906
    • Liu, H.Y.1    Hong, T.2    Wen, G.B.3
  • 47
    • 71949096402 scopus 로고    scopus 로고
    • Improved insulin sensitivity by calorie restriction is associated with reduction of ERK and p70S6K activities in the liver of obese Zucker rats
    • Y. Zheng, W. Zhang, and E. Pendleton Improved insulin sensitivity by calorie restriction is associated with reduction of ERK and p70S6K activities in the liver of obese Zucker rats J. Endocrinol. 203 2009 337 347
    • (2009) J. Endocrinol. , vol.203 , pp. 337-347
    • Zheng, Y.1    Zhang, W.2    Pendleton, E.3
  • 48
    • 84884210651 scopus 로고    scopus 로고
    • Obesity as the common soil of non-alcoholic fatty liver disease and diabetes: Role of adipokines
    • E. Hui, A. Xu, H. Bo Yang, and K.S. Lam Obesity as the common soil of non-alcoholic fatty liver disease and diabetes: role of adipokines J. Diabetes Investig. 4 2013 413 425
    • (2013) J. Diabetes Investig. , vol.4 , pp. 413-425
    • Hui, E.1    Xu, A.2    Bo Yang, H.3    Lam, K.S.4
  • 49
    • 84876545898 scopus 로고    scopus 로고
    • Chronic inhibition of 11 beta-hydroxysteroid dehydrogenase type 1 activity decreases hypertension, insulin resistance, and hypertriglyceridemia in metabolic syndrome
    • C.G. Schnackenberg, M.H. Costell, and D.J. Krosky Chronic inhibition of 11 beta-hydroxysteroid dehydrogenase type 1 activity decreases hypertension, insulin resistance, and hypertriglyceridemia in metabolic syndrome Biomed. Res. Int. 2013 2013 427640
    • (2013) Biomed. Res. Int. , vol.2013 , pp. 427640
    • Schnackenberg, C.G.1    Costell, M.H.2    Krosky, D.J.3
  • 50
    • 84866271508 scopus 로고    scopus 로고
    • Endogenous glucocorticoids in inflammation: Contributions of systemic and local responses
    • R.S. Hardy, K. Raza, and M.S. Cooper Endogenous glucocorticoids in inflammation: contributions of systemic and local responses Swiss Med. Wkly. 142 2012 w13650
    • (2012) Swiss Med. Wkly. , vol.142 , pp. w13650
    • Hardy, R.S.1    Raza, K.2    Cooper, M.S.3
  • 51
    • 0242468543 scopus 로고    scopus 로고
    • Selective inhibition of 11 beta-hydroxysteroid dehydrogenase type 1 improves hepatic insulin sensitivity in hyperglycemic mice strains
    • P. Alberts, C. Nilsson, and G. Selen Selective inhibition of 11 beta-hydroxysteroid dehydrogenase type 1 improves hepatic insulin sensitivity in hyperglycemic mice strains Endocrinology 144 2003 4755 4762
    • (2003) Endocrinology , vol.144 , pp. 4755-4762
    • Alberts, P.1    Nilsson, C.2    Selen, G.3
  • 52
    • 0035798621 scopus 로고    scopus 로고
    • Improved lipid and lipoprotein profile, hepatic insulin sensitivity, and glucose tolerance in 11beta-hydroxysteroid dehydrogenase type 1 null mice
    • N.M. Morton, M.C. Holmes, and C. Fievet Improved lipid and lipoprotein profile, hepatic insulin sensitivity, and glucose tolerance in 11beta-hydroxysteroid dehydrogenase type 1 null mice J. Biol. Chem. 276 2001 41293 41300
    • (2001) J. Biol. Chem. , vol.276 , pp. 41293-41300
    • Morton, N.M.1    Holmes, M.C.2    Fievet, C.3
  • 53
    • 84873742735 scopus 로고    scopus 로고
    • 11beta-Hydroxysteroid dehydrogenase type 1: Potential therapeutic target for metabolic syndrome
    • A. Joharapurkar, N. Dhanesha, G. Shah, R. Kharul, and M. Jain 11beta-Hydroxysteroid dehydrogenase type 1: potential therapeutic target for metabolic syndrome Pharmacol. Rep. 64 2012 1055 1065
    • (2012) Pharmacol. Rep. , vol.64 , pp. 1055-1065
    • Joharapurkar, A.1    Dhanesha, N.2    Shah, G.3    Kharul, R.4    Jain, M.5
  • 54
    • 70350540686 scopus 로고    scopus 로고
    • 11beta-Hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle
    • S.A. Morgan, M. Sherlock, and L.L. Gathercole 11beta-Hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle Diabetes 58 2009 2506 2515
    • (2009) Diabetes , vol.58 , pp. 2506-2515
    • Morgan, S.A.1    Sherlock, M.2    Gathercole, L.L.3
  • 55
    • 84863628857 scopus 로고    scopus 로고
    • BVT.2733, a selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitor, attenuates obesity and inflammation in diet-induced obese mice
    • L. Wang, J. Liu, and A. Zhang BVT.2733, a selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitor, attenuates obesity and inflammation in diet-induced obese mice PLoS One 7 2012 e40056
    • (2012) PLoS One , vol.7 , pp. e40056
    • Wang, L.1    Liu, J.2    Zhang, A.3
  • 56
    • 33646423263 scopus 로고    scopus 로고
    • Effect of voluntary exercise on peripheral tissue glucocorticoid receptor content and the expression and activity of 11beta-HSD1 in the Syrian hamster
    • A.E. Coutinho, J.E. Campbell, S. Fediuc, and M.C. Riddell Effect of voluntary exercise on peripheral tissue glucocorticoid receptor content and the expression and activity of 11beta-HSD1 in the Syrian hamster J. Appl. Physiol. 100 2006 1483 1488
    • (2006) J. Appl. Physiol. , vol.100 , pp. 1483-1488
    • Coutinho, A.E.1    Campbell, J.E.2    Fediuc, S.3    Riddell, M.C.4
  • 57
    • 84894703144 scopus 로고    scopus 로고
    • Sirtuin-1 is a nutrient-dependent modulator of inflammation
    • M.E. Kotas, M.C. Gorecki, and M.P. Gillum Sirtuin-1 is a nutrient-dependent modulator of inflammation Adipocytes 2 2013 113 118
    • (2013) Adipocytes , vol.2 , pp. 113-118
    • Kotas, M.E.1    Gorecki, M.C.2    Gillum, M.P.3
  • 58
    • 79251544870 scopus 로고    scopus 로고
    • Feedback regulation of hepatic gluconeogenesis through modulation of SHP/Nr0b2 gene expression by Sirt1 and FoxO1
    • D. Wei, R. Tao, Y. Zhang, M.F. White, and X.C. Dong Feedback regulation of hepatic gluconeogenesis through modulation of SHP/Nr0b2 gene expression by Sirt1 and FoxO1 Am. J. Physiol. Endocrinol. Metab. 300 2011 E312 E320
    • (2011) Am. J. Physiol. Endocrinol. Metab. , vol.300 , pp. E312-E320
    • Wei, D.1    Tao, R.2    Zhang, Y.3    White, M.F.4    Dong, X.C.5
  • 59
    • 77954515012 scopus 로고    scopus 로고
    • Lack of SIRT1 (mammalian sirtuin 1) activity leads to liver steatosis in the SIRT1 +/- mice: A role of lipid mobilization and inflammation
    • F. Xu, Z. Gao, and J. Zhang Lack of SIRT1 (mammalian sirtuin 1) activity leads to liver steatosis in the SIRT1 +/- mice: a role of lipid mobilization and inflammation Endocrinology 151 2010 2504 2514
    • (2010) Endocrinology , vol.151 , pp. 2504-2514
    • Xu, F.1    Gao, Z.2    Zhang, J.3
  • 60
    • 3242719545 scopus 로고    scopus 로고
    • Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase
    • F. Yeung, J.E. Hoberg, and C.S. Ramsey Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase EMBO J. 23 2004 2369 2380
    • (2004) EMBO J. , vol.23 , pp. 2369-2380
    • Yeung, F.1    Hoberg, J.E.2    Ramsey, C.S.3
  • 61
    • 34548857700 scopus 로고    scopus 로고
    • SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B
    • C. Sun, F. Zhang, and X. Ge SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B Cell Metab. 6 2007 307 319
    • (2007) Cell Metab. , vol.6 , pp. 307-319
    • Sun, C.1    Zhang, F.2    Ge, X.3
  • 62
    • 80053910309 scopus 로고    scopus 로고
    • JNKs, insulin resistance and inflammation: A possible link between NAFLD and coronary artery disease
    • G. Tarantino, and A. Caputi JNKs, insulin resistance and inflammation: a possible link between NAFLD and coronary artery disease World J. Gastroenterol. 17 2011 3785 3794
    • (2011) World J. Gastroenterol. , vol.17 , pp. 3785-3794
    • Tarantino, G.1    Caputi, A.2
  • 63
    • 84455162004 scopus 로고    scopus 로고
    • Serum Bcl-2 concentrations in overweight-obese subjects with nonalcoholic fatty liver disease
    • G. Tarantino, F. Scopacasa, and A. Colao Serum Bcl-2 concentrations in overweight-obese subjects with nonalcoholic fatty liver disease World J. Gastroenterol. 17 2011 5280 5288
    • (2011) World J. Gastroenterol. , vol.17 , pp. 5280-5288
    • Tarantino, G.1    Scopacasa, F.2    Colao, A.3
  • 64
    • 79955700474 scopus 로고    scopus 로고
    • Circulating levels of cytochrome C, gamma-glutamyl transferase, triglycerides and unconjugated bilirubin in overweight/obese patients with non-alcoholic fatty liver disease
    • G. Tarantino, A. Colao, and D. Capone Circulating levels of cytochrome C, gamma-glutamyl transferase, triglycerides and unconjugated bilirubin in overweight/obese patients with non-alcoholic fatty liver disease J. Biol. Regul. Homeost. Agents 25 2011 47 56
    • (2011) J. Biol. Regul. Homeost. Agents , vol.25 , pp. 47-56
    • Tarantino, G.1    Colao, A.2    Capone, D.3
  • 65
    • 0041677606 scopus 로고    scopus 로고
    • Principles of interleukin (IL)-6-type cytokine signalling and its regulation
    • P.C. Heinrich, I. Behrmann, and S. Haan Principles of interleukin (IL)-6-type cytokine signalling and its regulation Biochem. J. 374 2003 1 20
    • (2003) Biochem. J. , vol.374 , pp. 1-20
    • Heinrich, P.C.1    Behrmann, I.2    Haan, S.3
  • 66
    • 84893316263 scopus 로고    scopus 로고
    • Regulation of IL-6-type cytokine responses by MAPKs
    • A.P. Costa-Pereira Regulation of IL-6-type cytokine responses by MAPKs Biochem. Soc. Trans. 42 2014 59 62
    • (2014) Biochem. Soc. Trans. , vol.42 , pp. 59-62
    • Costa-Pereira, A.P.1
  • 67
    • 33644823811 scopus 로고    scopus 로고
    • Leukaemia inhibitory factor stimulates glucose transport in isolated cardiomyocytes and induces insulin resistance after chronic exposure
    • G. Florholmen, G.H. Thoresen, and A.C. Rustan Leukaemia inhibitory factor stimulates glucose transport in isolated cardiomyocytes and induces insulin resistance after chronic exposure Diabetologia 49 2006 724 731
    • (2006) Diabetologia , vol.49 , pp. 724-731
    • Florholmen, G.1    Thoresen, G.H.2    Rustan, A.C.3
  • 68
    • 84873720119 scopus 로고    scopus 로고
    • What is the role of adiponectin in obesity related non-alcoholic fatty liver disease?
    • C. Finelli, and G. Tarantino What is the role of adiponectin in obesity related non-alcoholic fatty liver disease? World J. Gastroenterol. 19 2013 802 812
    • (2013) World J. Gastroenterol. , vol.19 , pp. 802-812
    • Finelli, C.1    Tarantino, G.2
  • 69
    • 20444371324 scopus 로고    scopus 로고
    • Signalling links in the liver: Knitting SOCS with fat and inflammation
    • G.C. Farrell Signalling links in the liver: knitting SOCS with fat and inflammation J. Hepatol. 43 2005 193 196
    • (2005) J. Hepatol. , vol.43 , pp. 193-196
    • Farrell, G.C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.