-
2
-
-
53149132796
-
Voluntary exercise improves insulin sensitivity and adipose tissue inflammation in diet-induced obese mice
-
Bradley R.L., Jeon J.Y., Liu F.F., and Maratos-Flier E. Voluntary exercise improves insulin sensitivity and adipose tissue inflammation in diet-induced obese mice. Am. J. Physiol. Endocrinol. Metab. 295 (2008) E586-594
-
(2008)
Am. J. Physiol. Endocrinol. Metab.
, vol.295
-
-
Bradley, R.L.1
Jeon, J.Y.2
Liu, F.F.3
Maratos-Flier, E.4
-
3
-
-
0037011917
-
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
-
Calfon M., Zeng H., Urano F., Till J.H., Hubbard S.R., Harding H.P., Clark S.G., and Ron D. IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature 415 (2002) 92-96
-
(2002)
Nature
, vol.415
, pp. 92-96
-
-
Calfon, M.1
Zeng, H.2
Urano, F.3
Till, J.H.4
Hubbard, S.R.5
Harding, H.P.6
Clark, S.G.7
Ron, D.8
-
4
-
-
18144446836
-
Circulating insulin-like growth factor I mediates effects of exercise on the brain
-
Carro E., Nunez A., Busiguina S., and Torres-Aleman I. Circulating insulin-like growth factor I mediates effects of exercise on the brain. J. Neurosci. 20 (2000) 2926-2933
-
(2000)
J. Neurosci.
, vol.20
, pp. 2926-2933
-
-
Carro, E.1
Nunez, A.2
Busiguina, S.3
Torres-Aleman, I.4
-
6
-
-
40149096250
-
Short-term high fat-feeding results in morphological and metabolic adaptations in the skeletal muscle of C57BL/6J mice
-
de Wilde J., Mohren R., van den Berg S., Boekschoten M., Dijk K.W., de Groot P., Muller M., Mariman E., and Smit E. Short-term high fat-feeding results in morphological and metabolic adaptations in the skeletal muscle of C57BL/6J mice. Physiol. Genomics 32 (2008) 360-369
-
(2008)
Physiol. Genomics
, vol.32
, pp. 360-369
-
-
de Wilde, J.1
Mohren, R.2
van den Berg, S.3
Boekschoten, M.4
Dijk, K.W.5
de Groot, P.6
Muller, M.7
Mariman, E.8
Smit, E.9
-
7
-
-
0033590451
-
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
-
Harding H.P., Zhang Y., and Ron D. Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature 397 (1999) 271-274
-
(1999)
Nature
, vol.397
, pp. 271-274
-
-
Harding, H.P.1
Zhang, Y.2
Ron, D.3
-
8
-
-
0033634654
-
Regulated translation initiation controls stress-induced gene expression in mammalian cells
-
Harding H.P., Novoa I., Zhang Y., Zeng H., Wek R., Schapira M., and Ron D. Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol. Cell 6 (2000) 1099-1108
-
(2000)
Mol. Cell
, vol.6
, pp. 1099-1108
-
-
Harding, H.P.1
Novoa, I.2
Zhang, Y.3
Zeng, H.4
Wek, R.5
Schapira, M.6
Ron, D.7
-
9
-
-
59649113290
-
Voluntary exercise prevents the obese and diabetic metabolic syndrome of the melanocortin-4 receptor knockout mouse
-
Haskell-Luevano C., Schaub J.W., Andreasen A., Haskell K.R., Moore M.C., Koerper L.M., Rouzaud F., Baker H.V., Millard W.J., Walter G., Litherland S.A., and Xiang Z. Voluntary exercise prevents the obese and diabetic metabolic syndrome of the melanocortin-4 receptor knockout mouse. FASEB J. 23 (2009) 642-655
-
(2009)
FASEB J.
, vol.23
, pp. 642-655
-
-
Haskell-Luevano, C.1
Schaub, J.W.2
Andreasen, A.3
Haskell, K.R.4
Moore, M.C.5
Koerper, L.M.6
Rouzaud, F.7
Baker, H.V.8
Millard, W.J.9
Walter, G.10
Litherland, S.A.11
Xiang, Z.12
-
10
-
-
0032693671
-
Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress
-
Haze K., Yoshida H., Yanagi H., Yura T., and Mori K. Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress. Mol. Biol. Cell 10 (1999) 3787-3799
-
(1999)
Mol. Biol. Cell
, vol.10
, pp. 3787-3799
-
-
Haze, K.1
Yoshida, H.2
Yanagi, H.3
Yura, T.4
Mori, K.5
-
11
-
-
0035147411
-
Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress
-
Iwawaki T., Hosoda A., Okuda T., Kamigori Y., Nomura-Furuwatari C., Kimata Y., Tsuru A., and Kohno K. Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress. Nat. Cell Biol. 3 (2001) 158-164
-
(2001)
Nat. Cell Biol.
, vol.3
, pp. 158-164
-
-
Iwawaki, T.1
Hosoda, A.2
Okuda, T.3
Kamigori, Y.4
Nomura-Furuwatari, C.5
Kimata, Y.6
Tsuru, A.7
Kohno, K.8
-
12
-
-
56349098932
-
Lighting up the stressed ER
-
Kang S.W., and Hegde R.S. Lighting up the stressed ER. Cell 135 (2008) 787-789
-
(2008)
Cell
, vol.135
, pp. 787-789
-
-
Kang, S.W.1
Hegde, R.S.2
-
13
-
-
0033562966
-
Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls
-
Kaufman R.J. Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. Genes Dev. 13 (1999) 1211-1233
-
(1999)
Genes Dev.
, vol.13
, pp. 1211-1233
-
-
Kaufman, R.J.1
-
14
-
-
0036853914
-
Orchestrating the unfolded protein response in health and disease
-
Kaufman R.J. Orchestrating the unfolded protein response in health and disease. J. Clin. Invest. 110 (2002) 1389-1398
-
(2002)
J. Clin. Invest.
, vol.110
, pp. 1389-1398
-
-
Kaufman, R.J.1
-
15
-
-
0037083755
-
IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response
-
Lee K., Tirasophon W., Shen X., Michalak M., Prywes R., Okada T., Yoshida H., Mori K., and Kaufman R.J. IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response. Genes Dev. 16 (2002) 452-466
-
(2002)
Genes Dev.
, vol.16
, pp. 452-466
-
-
Lee, K.1
Tirasophon, W.2
Shen, X.3
Michalak, M.4
Prywes, R.5
Okada, T.6
Yoshida, H.7
Mori, K.8
Kaufman, R.J.9
-
16
-
-
33645474088
-
Differential effects of exercise on body weight gain and adiposity in obesity-prone and -resistant rats
-
Levin B.E., and Dunn-Meynell A.A. Differential effects of exercise on body weight gain and adiposity in obesity-prone and -resistant rats. Int. J. Obes. (Lond.) 30 (2006) 722-727
-
(2006)
Int. J. Obes. (Lond.)
, vol.30
, pp. 722-727
-
-
Levin, B.E.1
Dunn-Meynell, A.A.2
-
17
-
-
0033920261
-
ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1
-
Li M., Baumeister P., Roy B., Phan T., Foti D., Luo S., and Lee A.S. ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1. Mol. Cell. Biol. 20 (2000) 5096-5106
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 5096-5106
-
-
Li, M.1
Baumeister, P.2
Roy, B.3
Phan, T.4
Foti, D.5
Luo, S.6
Lee, A.S.7
-
19
-
-
0035966320
-
The unfolding tale of the unfolded protein response
-
Ma Y., and Hendershot L.M. The unfolding tale of the unfolded protein response. Cell 107 (2001) 827-830
-
(2001)
Cell
, vol.107
, pp. 827-830
-
-
Ma, Y.1
Hendershot, L.M.2
-
20
-
-
52049118494
-
Physical activity and neuroprotection in amyotrophic lateral sclerosis
-
McCrate M.E., and Kaspar B.K. Physical activity and neuroprotection in amyotrophic lateral sclerosis. Neuromolecular. Med. 10 (2008) 108-117
-
(2008)
Neuromolecular. Med.
, vol.10
, pp. 108-117
-
-
McCrate, M.E.1
Kaspar, B.K.2
-
21
-
-
34548387856
-
Short-term exercise does not increase ER stress protein expression in cardiac muscle
-
Murlasits Z., Lee Y., and Powers S.K. Short-term exercise does not increase ER stress protein expression in cardiac muscle. Med. Sci. Sports Exerc. 39 (2007) 1522-1528
-
(2007)
Med. Sci. Sports Exerc.
, vol.39
, pp. 1522-1528
-
-
Murlasits, Z.1
Lee, Y.2
Powers, S.K.3
-
22
-
-
0033598996
-
A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response
-
Niwa M., Sidrauski C., Kaufman R.J., and Walter P. A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response. Cell 99 (1999) 691-702
-
(1999)
Cell
, vol.99
, pp. 691-702
-
-
Niwa, M.1
Sidrauski, C.2
Kaufman, R.J.3
Walter, P.4
-
23
-
-
48749105887
-
Activation of hypothalamic S6 kinase mediates diet-induced hepatic insulin resistance in rats
-
Ono H., Pocai A., Wang Y., Sakoda H., Asano T., Backer J.M., Schwartz G.J., and Rossetti L. Activation of hypothalamic S6 kinase mediates diet-induced hepatic insulin resistance in rats. J. Clin. Invest. 118 (2008) 2959-2968
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 2959-2968
-
-
Ono, H.1
Pocai, A.2
Wang, Y.3
Sakoda, H.4
Asano, T.5
Backer, J.M.6
Schwartz, G.J.7
Rossetti, L.8
-
24
-
-
5644231992
-
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
-
Ozcan U., Cao Q., Yilmaz E., Lee A.H., Iwakoshi N.N., Ozdelen E., Tuncman G., Gorgun C., Glimcher L.H., and Hotamisligil G.S. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 306 (2004) 457-461
-
(2004)
Science
, vol.306
, pp. 457-461
-
-
Ozcan, U.1
Cao, Q.2
Yilmaz, E.3
Lee, A.H.4
Iwakoshi, N.N.5
Ozdelen, E.6
Tuncman, G.7
Gorgun, C.8
Glimcher, L.H.9
Hotamisligil, G.S.10
-
25
-
-
33748069813
-
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
-
Ozcan U., Yilmaz E., Ozcan L., Furuhashi M., Vaillancourt E., Smith R.O., Gorgun C.Z., and Hotamisligil G.S. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 313 (2006) 1137-1140
-
(2006)
Science
, vol.313
, pp. 1137-1140
-
-
Ozcan, U.1
Yilmaz, E.2
Ozcan, L.3
Furuhashi, M.4
Vaillancourt, E.5
Smith, R.O.6
Gorgun, C.Z.7
Hotamisligil, G.S.8
-
26
-
-
57849115277
-
Endoplasmic reticulum stress plays a central role in development of leptin resistance
-
Ozcan L., Ergin A.S., Lu A., Chung J., Sarkar S., Nie D., Myers Jr. M.G., and Ozcan U. Endoplasmic reticulum stress plays a central role in development of leptin resistance. Cell Metab. 9 (2009) 35-51
-
(2009)
Cell Metab.
, vol.9
, pp. 35-51
-
-
Ozcan, L.1
Ergin, A.S.2
Lu, A.3
Chung, J.4
Sarkar, S.5
Nie, D.6
Myers Jr., M.G.7
Ozcan, U.8
-
27
-
-
57049143045
-
Benefits of physical exercise for older adults with Alzheimer's disease
-
Perez C.A., and Cancela Carral J.M. Benefits of physical exercise for older adults with Alzheimer's disease. Geriatr. Nurs. 29 (2008) 384-391
-
(2008)
Geriatr. Nurs.
, vol.29
, pp. 384-391
-
-
Perez, C.A.1
Cancela Carral, J.M.2
-
28
-
-
60749100350
-
Restorative effect of endurance exercise on behavioral deficits in the chronic mouse model of Parkinson's disease with severe neurodegeneration
-
Pothakos K., Kurz M.J., and Lau Y.S. Restorative effect of endurance exercise on behavioral deficits in the chronic mouse model of Parkinson's disease with severe neurodegeneration. BMC Neurosci. 10 (2009) 6
-
(2009)
BMC Neurosci.
, vol.10
, pp. 6
-
-
Pothakos, K.1
Kurz, M.J.2
Lau, Y.S.3
-
29
-
-
45649084573
-
Physical activity and Alzheimer's disease: from prevention to therapeutic perspectives
-
Rolland Y., Abellan van Kan G., and Vellas B. Physical activity and Alzheimer's disease: from prevention to therapeutic perspectives. J. Am. Med. Dir. Assoc. 9 (2008) 390-405
-
(2008)
J. Am. Med. Dir. Assoc.
, vol.9
, pp. 390-405
-
-
Rolland, Y.1
Abellan van Kan, G.2
Vellas, B.3
-
30
-
-
10444226462
-
ER stress and the unfolded protein response
-
Schroder M., and Kaufman R.J. ER stress and the unfolded protein response. Mutat. Res. 569 (2005) 29-63
-
(2005)
Mutat. Res.
, vol.569
, pp. 29-63
-
-
Schroder, M.1
Kaufman, R.J.2
-
31
-
-
18244405070
-
Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development
-
Shen X., Ellis R.E., Lee K., Liu C.Y., Yang K., Solomon A., Yoshida H., Morimoto R., Kurnit D.M., Mori K., and Kaufman R.J. Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development. Cell 107 (2001) 893-903
-
(2001)
Cell
, vol.107
, pp. 893-903
-
-
Shen, X.1
Ellis, R.E.2
Lee, K.3
Liu, C.Y.4
Yang, K.5
Solomon, A.6
Yoshida, H.7
Morimoto, R.8
Kurnit, D.M.9
Mori, K.10
Kaufman, R.J.11
-
32
-
-
0036069980
-
ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals
-
Shen J., Chen X., Hendershot L., and Prywes R. ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals. Dev. Cell 3 (2002) 99-111
-
(2002)
Dev. Cell
, vol.3
, pp. 99-111
-
-
Shen, J.1
Chen, X.2
Hendershot, L.3
Prywes, R.4
-
33
-
-
0031755020
-
Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control
-
Shi Y., Vattem K.M., Sood R., An J., Liang J., Stramm L., and Wek R.C. Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control. Mol. Cell. Biol. 18 (1998) 7499-7509
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 7499-7509
-
-
Shi, Y.1
Vattem, K.M.2
Sood, R.3
An, J.4
Liang, J.5
Stramm, L.6
Wek, R.C.7
-
34
-
-
34249709339
-
BDNF induction with mild exercise in the rat hippocampus
-
Soya H., Nakamura T., Deocaris C.C., Kimpara A., Iimura M., Fujikawa T., Chang H., McEwen B.S., and Nishijima T. BDNF induction with mild exercise in the rat hippocampus. Biochem. Biophys. Res. Commun. 358 (2007) 961-967
-
(2007)
Biochem. Biophys. Res. Commun.
, vol.358
, pp. 961-967
-
-
Soya, H.1
Nakamura, T.2
Deocaris, C.C.3
Kimpara, A.4
Iimura, M.5
Fujikawa, T.6
Chang, H.7
McEwen, B.S.8
Nishijima, T.9
-
35
-
-
0032525990
-
A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells
-
Tirasophon W., Welihinda A.A., and Kaufman R.J. A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells. Genes Dev. 12 (1998) 1812-1824
-
(1998)
Genes Dev.
, vol.12
, pp. 1812-1824
-
-
Tirasophon, W.1
Welihinda, A.A.2
Kaufman, R.J.3
-
36
-
-
0034724520
-
Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation
-
Travers K.J., Patil C.K., Wodicka L., Lockhart D.J., Weissman J.S., and Walter P. Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation. Cell 101 (2000) 249-258
-
(2000)
Cell
, vol.101
, pp. 249-258
-
-
Travers, K.J.1
Patil, C.K.2
Wodicka, L.3
Lockhart, D.J.4
Weissman, J.S.5
Walter, P.6
-
37
-
-
0032190546
-
Cloning of mammalian Ire1 reveals diversity in the ER stress responses
-
Wang X.Z., Harding H.P., Zhang Y., Jolicoeur E.M., Kuroda M., and Ron D. Cloning of mammalian Ire1 reveals diversity in the ER stress responses. EMBO J. 17 (1998) 5708-5717
-
(1998)
EMBO J.
, vol.17
, pp. 5708-5717
-
-
Wang, X.Z.1
Harding, H.P.2
Zhang, Y.3
Jolicoeur, E.M.4
Kuroda, M.5
Ron, D.6
-
38
-
-
0034515724
-
ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs
-
Ye J., Rawson R.B., Komuro R., Chen X., Dave U.P., Prywes R., Brown M.S., and Goldstein J.L. ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. Mol. Cell 6 (2000) 1355-1364
-
(2000)
Mol. Cell
, vol.6
, pp. 1355-1364
-
-
Ye, J.1
Rawson, R.B.2
Komuro, R.3
Chen, X.4
Dave, U.P.5
Prywes, R.6
Brown, M.S.7
Goldstein, J.L.8
-
39
-
-
0032509216
-
Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors
-
Yoshida H., Haze K., Yanagi H., Yura T., and Mori K. Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors. J. Biol. Chem. 273 (1998) 33741-33749
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 33741-33749
-
-
Yoshida, H.1
Haze, K.2
Yanagi, H.3
Yura, T.4
Mori, K.5
-
40
-
-
0035966269
-
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor
-
Yoshida H., Matsui T., Yamamoto A., Okada T., and Mori K. XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell 107 (2001) 881-891
-
(2001)
Cell
, vol.107
, pp. 881-891
-
-
Yoshida, H.1
Matsui, T.2
Yamamoto, A.3
Okada, T.4
Mori, K.5
-
41
-
-
52949096557
-
Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity
-
Zhang X., Zhang G., Zhang H., Karin M., Bai H., and Cai D. Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity. Cell 135 (2008) 61-73
-
(2008)
Cell
, vol.135
, pp. 61-73
-
-
Zhang, X.1
Zhang, G.2
Zhang, H.3
Karin, M.4
Bai, H.5
Cai, D.6
|