메뉴 건너뛰기




Volumn 289, Issue 3, 2014, Pages 1203-1211

Unfolded protein response signaling and metabolic diseases

Author keywords

[No Author keywords available]

Indexed keywords

ENDOPLASMIC RETICULUM; METABOLIC DISEASE; METABOLIC DISORDERS; PROTEIN BIOSYNTHESIS; SIGNALING CASCADES; SIGNALING COMPONENTS; SIGNALING PATHWAYS; UNFOLDED PROTEIN RESPONSE;

EID: 84892646801     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.R113.534743     Document Type: Review
Times cited : (239)

References (100)
  • 1
    • 84881478531 scopus 로고    scopus 로고
    • Potential for therapeutic manipulation of the UPR in disease
    • Park, S. W., and Ozcan, U. (2013) Potential for therapeutic manipulation of the UPR in disease. Semin. Immunopathol. 35, 351-373
    • (2013) Semin. Immunopathol. , vol.35 , pp. 351-373
    • Park, S.W.1    Ozcan, U.2
  • 2
    • 0027324844 scopus 로고
    • Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase
    • DOI 10.1016/0092-8674(93)90648-A
    • Cox, J. S., Shamu, C. E., and Walter, P. (1993) Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase. Cell 73, 1197-1206 (Pubitemid 23180493)
    • (1993) Cell , vol.73 , Issue.6 , pp. 1197-1206
    • Cox, J.S.1    Shamu, C.E.2    Walter, P.3
  • 3
    • 0032525990 scopus 로고    scopus 로고
    • A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells
    • Tirasophon, W., Welihinda, A. A., and Kaufman, R. J. (1998) A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells. Genes Dev. 12, 1812-1824 (Pubitemid 28304334)
    • (1998) Genes and Development , vol.12 , Issue.12 , pp. 1812-1824
    • Tirasophon, W.1    Welihinda, A.A.2    Kaufman, R.J.3
  • 6
    • 0033782015 scopus 로고    scopus 로고
    • Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response
    • Bertolotti, A., Zhang, Y., Hendershot, L. M., Harding, H. P., and Ron, D. (2000) Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. Nat. Cell Biol. 2, 326-332
    • (2000) Nat. Cell Biol. , vol.2 , pp. 326-332
    • Bertolotti, A.1    Zhang, Y.2    Hendershot, L.M.3    Harding, H.P.4    Ron, D.5
  • 7
    • 80053369081 scopus 로고    scopus 로고
    • Unfolded proteins are Ire1-activating ligands that directly induce the unfolded protein response
    • Gardner, B. M., and Walter, P. (2011) Unfolded proteins are Ire1-activating ligands that directly induce the unfolded protein response. Science 333, 1891-1894
    • (2011) Science , vol.333 , pp. 1891-1894
    • Gardner, B.M.1    Walter, P.2
  • 8
    • 37649004940 scopus 로고    scopus 로고
    • Structure of the dual enzyme Ire1 reveals the basis for catalysis and regulation in nonconventional RNA splicing
    • Lee, K. P., Dey, M., Neculai, D., Cao, C., Dever, T. E., and Sicheri, F. (2008) Structure of the dual enzyme Ire1 reveals the basis for catalysis and regulation in nonconventional RNA splicing. Cell 132, 89-100
    • (2008) Cell , vol.132 , pp. 89-100
    • Lee, K.P.1    Dey, M.2    Neculai, D.3    Cao, C.4    Dever, T.E.5    Sicheri, F.6
  • 9
    • 0035966269 scopus 로고    scopus 로고
    • XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor
    • DOI 10.1016/S0092-8674(01)00611-0
    • Yoshida, H., Matsui, T., Yamamoto, A., Okada, T., and Mori, K. (2001) XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell 107, 881-891 (Pubitemid 34084979)
    • (2001) Cell , vol.107 , Issue.7 , pp. 881-891
    • Yoshida, H.1    Matsui, T.2    Yamamoto, A.3    Okada, T.4    Mori, K.5
  • 10
    • 68549092781 scopus 로고    scopus 로고
    • Regulated Ire1-dependent decay of messenger RNAs in mammalian cells
    • Hollien, J., Lin, J. H., Li, H., Stevens, N., Walter, P., and Weissman, J. S. (2009) Regulated Ire1-dependent decay of messenger RNAs in mammalian cells. J. Cell Biol. 186, 323-331
    • (2009) J. Cell Biol. , vol.186 , pp. 323-331
    • Hollien, J.1    Lin, J.H.2    Li, H.3    Stevens, N.4    Walter, P.5    Weissman, J.S.6
  • 11
    • 68049110633 scopus 로고    scopus 로고
    • IRE1β kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates
    • Han, D., Lerner, A. G., Vande Walle, L., Upton, J. P., Xu, W., Hagen, A., Backes, B. J., Oakes, S. A., and Papa, F. R. (2009) IRE1β kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates. Cell 138, 562-575
    • (2009) Cell , vol.138 , pp. 562-575
    • Han, D.1    Lerner, A.G.2    Vande Walle, L.3    Upton, J.P.4    Xu, W.5    Hagen, A.6    Backes, B.J.7    Oakes, S.A.8    Papa, F.R.9
  • 13
    • 14944371187 scopus 로고    scopus 로고
    • The unfolded protein response sensor IRE1α is required at 2 distinct steps in B cell lymphopoiesis
    • DOI 10.1172/JCI200521848
    • Zhang, K., Wong, H. N., Song, B., Miller, C. N., Scheuner, D., and Kaufman, R. J. (2005) The unfolded protein response sensor IRE1β is required at 2 distinct steps in B cell lymphopoiesis. J. Clin. Invest. 115, 268-281 (Pubitemid 40385469)
    • (2005) Journal of Clinical Investigation , vol.115 , Issue.2 , pp. 268-281
    • Zhang, K.1    Wong, H.N.2    Song, B.3    Miller, C.N.4    Scheuner, D.5    Kaufman, R.J.6
  • 15
    • 0033516930 scopus 로고    scopus 로고
    • Targeted disruption of CRE-Binding factor TREB5 gene leads to cellular necrosis in cardiac myocytes at the embryonic stage
    • DOI 10.1006/bbrc.1999.0972
    • Masaki, T., Yoshida, M., and Noguchi, S. (1999) Targeted disruption of CRE-binding factor TREB5 gene leads to cellular necrosis in cardiac myocytes at the embryonic stage. Biochem. Biophys. Res. Commun. 261, 350-356 (Pubitemid 29392480)
    • (1999) Biochemical and Biophysical Research Communications , vol.261 , Issue.2 , pp. 350-356
    • Masaki, T.1    Yoshida, M.2    Noguchi, S.3
  • 16
    • 0034723235 scopus 로고    scopus 로고
    • Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
    • DOI 10.1126/science.287.5453.664
    • Urano, F., Wang, X., Bertolotti, A., Zhang, Y., Chung, P., Harding, H. P., and Ron, D. (2000) Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 287, 664-666 (Pubitemid 30070916)
    • (2000) Science , vol.287 , Issue.5453 , pp. 664-666
    • Urano, F.1    Wang, X.2    Bertolotti, A.3    Zhang, Y.4    Chung, P.5    Harding, H.P.6    Ron, D.7
  • 17
    • 0035957929 scopus 로고    scopus 로고
    • Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress
    • Yoneda, T., Imaizumi, K., Oono, K., Yui, D., Gomi, F., Katayama, T., and Tohyama, M. (2001) Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress. J. Biol. Chem. 276, 13935-13940
    • (2001) J. Biol. Chem. , vol.276 , pp. 13935-13940
    • Yoneda, T.1    Imaizumi, K.2    Oono, K.3    Yui, D.4    Gomi, F.5    Katayama, T.6    Tohyama, M.7
  • 18
    • 0036606540 scopus 로고    scopus 로고
    • ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats
    • DOI 10.1101/gad.992302
    • Nishitoh, H., Matsuzawa, A., Tobiume, K., Saegusa, K., Takeda, K., Inoue, K., Hori, S., Kakizuka, A., and Ichijo, H. (2002) ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats. Genes Dev. 16, 1345-1355 (Pubitemid 34615088)
    • (2002) Genes and Development , vol.16 , Issue.11 , pp. 1345-1355
    • Nishitoh, H.1    Matsuzawa, A.2    Tobiume, K.3    Saegusa, K.4    Takeda, K.5    Inoue, K.6    Hori, S.7    Kakizuka, A.8    Ichijo, H.9
  • 19
    • 45549103421 scopus 로고    scopus 로고
    • AIP1 is critical in transducing IRE1-mediated endoplasmic reticulum stress response
    • Luo, D., He, Y., Zhang, H., Yu, L., Chen, H., Xu, Z., Tang, S., Urano, F., and Min, W. (2008) AIP1 is critical in transducing IRE1-mediated endoplasmic reticulum stress response. J. Biol. Chem. 283, 11905-11912
    • (2008) J. Biol. Chem. , vol.283 , pp. 11905-11912
    • Luo, D.1    He, Y.2    Zhang, H.3    Yu, L.4    Chen, H.5    Xu, Z.6    Tang, S.7    Urano, F.8    Min, W.9
  • 20
    • 77649135472 scopus 로고    scopus 로고
    • An essential role for XBP-1 in host protection against immune activation in C. Elegans
    • Richardson, C. E., Kooistra, T., and Kim, D. H. (2010) An essential role for XBP-1 in host protection against immune activation in C. elegans. Nature 463, 1092-1095
    • (2010) Nature , vol.463 , pp. 1092-1095
    • Richardson, C.E.1    Kooistra, T.2    Kim, D.H.3
  • 26
    • 9644303176 scopus 로고    scopus 로고
    • Protein-tyrosine phosphatase 1B potentiates IRE1 signaling during endoplasmic reticulum stress
    • DOI 10.1074/jbc.C400261200
    • Gu, F., Nguyên, D. T., Stuible, M., Dubé, N., Tremblay, M. L., and Chevet, E. (2004) Protein-tyrosine phosphatase 1B potentiates IRE1 signaling during endoplasmic reticulum stress. J. Biol. Chem. 279, 49689-49693 (Pubitemid 39577772)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.48 , pp. 49689-49693
    • Gu, F.1    Duc, T.N.2    Stuible, M.3    Dube, N.4    Tremblay, M.L.5    Chevet, E.6
  • 27
    • 77950523710 scopus 로고    scopus 로고
    • The regulatory subunits of PI3K, p85α and p85β, interact with XBP-1 and increase its nuclear translocation
    • Park, S. W., Zhou, Y., Lee, J., Lu, A., Sun, C., Chung, J., Ueki, K., and Ozcan, U. (2010) The regulatory subunits of PI3K, p85α and p85β, interact with XBP-1 and increase its nuclear translocation. Nat. Med. 16, 429-437
    • (2010) Nat. Med. , vol.16 , pp. 429-437
    • Park, S.W.1    Zhou, Y.2    Lee, J.3    Lu, A.4    Sun, C.5    Chung, J.6    Ueki, K.7    Ozcan, U.8
  • 28
    • 77950537400 scopus 로고    scopus 로고
    • A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response
    • Winnay, J. N., Boucher, J., Mori, M. A., Ueki, K., and Kahn, C. R. (2010) A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response. Nat. Med. 16, 438-445
    • (2010) Nat. Med. , vol.16 , pp. 438-445
    • Winnay, J.N.1    Boucher, J.2    Mori, M.A.3    Ueki, K.4    Kahn, C.R.5
  • 32
    • 79957773163 scopus 로고    scopus 로고
    • Dual and opposing roles of the unfolded protein response regulated by IRE1β and XBP1 in proinsulin processing and insulin secretion
    • Lee, A. H., Heidtman, K., Hotamisligil, G. S., and Glimcher, L. H. (2011) Dual and opposing roles of the unfolded protein response regulated by IRE1β and XBP1 in proinsulin processing and insulin secretion. Proc. Natl. Acad. Sci. U.S.A. 108, 8885-8890
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 8885-8890
    • Lee, A.H.1    Heidtman, K.2    Hotamisligil, G.S.3    Glimcher, L.H.4
  • 33
    • 84867063735 scopus 로고    scopus 로고
    • IRE1β-XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasis
    • Wang, S., Chen, Z., Lam, V., Han, J., Hassler, J., Finck, B. N., Davidson, N. O., and Kaufman, R. J. (2012) IRE1β-XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasis. Cell Metab. 16, 473-486
    • (2012) Cell Metab. , vol.16 , pp. 473-486
    • Wang, S.1    Chen, Z.2    Lam, V.3    Han, J.4    Hassler, J.5    Finck, B.N.6    Davidson, N.O.7    Kaufman, R.J.8
  • 34
    • 0033590451 scopus 로고    scopus 로고
    • Protein translation and folding are coupled by an endoplasmic- reticulum-resident kinase
    • DOI 10.1038/16729
    • Harding, H. P., Zhang, Y., and Ron, D. (1999) Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature 397, 271-274 (Pubitemid 29051178)
    • (1999) Nature , vol.397 , Issue.6716 , pp. 271-274
    • Harding, H.P.1    Zhang, Y.2    Ron, D.3
  • 35
    • 0037166237 scopus 로고    scopus 로고
    • Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress
    • DOI 10.1074/jbc.M200903200
    • Ma, K., Vattem, K. M., and Wek, R. C. (2002) Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress. J. Biol. Chem. 277, 18728-18735 (Pubitemid 34952430)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.21 , pp. 18728-18735
    • Ma, K.1    Vattem, K.M.2    Wek, R.C.3
  • 36
    • 35848935017 scopus 로고    scopus 로고
    • Translational control and the unfolded protein response
    • DOI 10.1089/ars.2007.1764
    • Wek, R. C., and Cavener, D. R. (2007) Translational control and the unfolded protein response. Antioxid. Redox Signal. 9, 2357-2371 (Pubitemid 350064140)
    • (2007) Antioxidants and Redox Signaling , vol.9 , Issue.12 , pp. 2357-2371
    • Wek, R.C.1    Cavener, D.R.2
  • 38
    • 8644282751 scopus 로고    scopus 로고
    • Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2
    • DOI 10.1128/MCB.24.23.10161-10168.2004
    • Deng, J., Lu, P. D., Zhang, Y., Scheuner, D., Kaufman, R. J., Sonenberg, N., Harding, H. P., and Ron, D. (2004) Translational repression mediates activation of nuclear factor κB by phosphorylated translation initiation factor 2. Mol. Cell. Biol. 24, 10161-10168 (Pubitemid 39507856)
    • (2004) Molecular and Cellular Biology , vol.24 , Issue.23 , pp. 10161-10168
    • Deng, J.1    Lu, P.D.2    Zhang, Y.3    Scheuner, D.4    Kaufman, R.J.5    Sonenberg, N.6    Harding, H.P.7    Ron, D.8
  • 39
    • 0043133837 scopus 로고    scopus 로고
    • Phosphorylation of the α subunit of eukaryotic initiation factor 2 is required for activation of NF-κB in response to diverse cellular stresses
    • DOI 10.1128/MCB.23.16.5651-5663.2003
    • Jiang, H. Y., Wek, S. A., McGrath, B. C., Scheuner, D., Kaufman, R. J., Cavener, D. R., and Wek, R. C. (2003) Phosphorylation of the α subunit of eukaryotic initiation factor 2 is required for activation of NF-κB in response to diverse cellular stresses. Mol. Cell. Biol. 23, 5651-5663 (Pubitemid 36951330)
    • (2003) Molecular and Cellular Biology , vol.23 , Issue.16 , pp. 5651-5663
    • Jiang, H.-Y.1    Wek, S.A.2    McGrath, B.C.3    Scheuner, D.4    Kaufman, R.J.5    Cavener, D.R.6    Wek, R.C.7
  • 40
    • 0034968330 scopus 로고    scopus 로고
    • Diabetes mellitus and exocrine pancreatic dysfunction in Perk-/- mice reveals a role for translational control in secretory cell survival
    • DOI 10.1016/S1097-2765(01)00264-7
    • Harding, H. P., Zeng, H., Zhang, Y., Jungries, R., Chung, P., Plesken, H., Sabatini, D. D., and Ron, D. (2001) Diabetes mellitus and exocrine pancreatic dysfunction in Perk-/- mice reveals a role for translational control in secretory cell survival. Mol. Cell 7, 1153-1163 (Pubitemid 32607350)
    • (2001) Molecular Cell , vol.7 , Issue.6 , pp. 1153-1163
    • Harding, H.P.1    Zeng, H.2    Zhang, Y.3    Jungries, R.4    Chung, P.5    Plesken, H.6    Sabatini, D.D.7    Ron, D.8
  • 41
    • 84871878351 scopus 로고    scopus 로고
    • PERK is required in the adult pancreas and is essential for maintenance of glucose homeostasis
    • Gao, Y., Sartori, D. J., Li, C., Yu, Q. C., Kushner, J. A., Simon, M. C., and Diehl, J. A. (2012) PERK is required in the adult pancreas and is essential for maintenance of glucose homeostasis. Mol. Cell. Biol. 32, 5129-5139
    • (2012) Mol. Cell. Biol. , vol.32 , pp. 5129-5139
    • Gao, Y.1    Sartori, D.J.2    Li, C.3    Yu, Q.C.4    Kushner, J.A.5    Simon, M.C.6    Diehl, J.A.7
  • 42
    • 33749492425 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress signaling in disease
    • DOI 10.1152/physrev.00015.2006
    • Marciniak, S. J., and Ron, D. (2006) Endoplasmic reticulum stress signaling in disease. Physiol. Rev. 86, 1133-1149 (Pubitemid 44521649)
    • (2006) Physiological Reviews , vol.86 , Issue.4 , pp. 1133-1149
    • Marciniak, S.J.1    Ron, D.2
  • 43
    • 33751430251 scopus 로고    scopus 로고
    • PERK EIF2AK3 control of pancreatic β cell differentiation and proliferation is required for postnatal glucose homeostasis
    • DOI 10.1016/j.cmet.2006.11.002, PII S1550413106003640
    • Zhang, W., Feng, D., Li, Y., Iida, K., McGrath, B., and Cavener, D. R. (2006) PERK EIF2AK3 control of pancreatic β cell differentiation and proliferation is required for postnatal glucose homeostasis. Cell Metab. 4, 491-497 (Pubitemid 44817351)
    • (2006) Cell Metabolism , vol.4 , Issue.6 , pp. 491-497
    • Zhang, W.1    Feng, D.2    Li, Y.3    Iida, K.4    McGrath, B.5    Cavener, D.R.6
  • 44
    • 0034425698 scopus 로고    scopus 로고
    • EIF2AK3, encoding translation initiation factor 2-α kinase 3, is mutated in patients with Wolcott-Rallison syndrome
    • DOI 10.1038/78085
    • Delépine, M., Nicolino, M., Barrett, T., Golamaully, M., Lathrop, G. M., and Julier, C. (2000) EIF2AK3, encoding translation initiation factor 2-α kinase 3, is mutated in patients with Wolcott-Rallison syndrome. Nat. Genet. 25, 406-409 (Pubitemid 32983431)
    • (2000) Nature Genetics , vol.25 , Issue.4 , pp. 406-409
    • Delepine, M.1    Nicolino, M.2    Barrett, T.3    Golamaully, M.4    Mark Lathrop, G.5    Julier, C.6
  • 45
    • 0034973982 scopus 로고    scopus 로고
    • Translational control is required for the unfolded protein response and in vivo glucose homeostasis
    • DOI 10.1016/S1097-2765(01)00265-9
    • Scheuner, D., Song, B., McEwen, E., Liu, C., Laybutt, R., Gillespie, P., Saunders, T., Bonner-Weir, S., and Kaufman, R. J. (2001) Translational control is required for the unfolded protein response and in vivo glucose homeostasis. Mol. Cell 7, 1165-1176 (Pubitemid 32607351)
    • (2001) Molecular Cell , vol.7 , Issue.6 , pp. 1165-1176
    • Scheuner, D.1    Song, B.2    McEwen, E.3    Liu, C.4    Laybutt, R.5    Gillespie, P.6    Saunders, T.7    Bonner-Weir, S.8    Kaufman, R.J.9
  • 46
    • 22544444513 scopus 로고    scopus 로고
    • Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis
    • DOI 10.1038/nm1259
    • Scheuner, D., Vander Mierde, D., Song, B., Flamez, D., Creemers, J. W., Tsukamoto, K., Ribick, M., Schuit, F. C., and Kaufman, R. J. (2005) Control of mRNA translation preserves endoplasmic reticulum function inβ cells and maintains glucose homeostasis. Nat. Med. 11, 757-764 (Pubitemid 41021208)
    • (2005) Nature Medicine , vol.11 , Issue.7 , pp. 757-764
    • Scheuner, D.1    Mierde, D.V.2    Song, B.3    Flamez, D.4    Creemers, J.W.M.5    Tsukamoto, K.6    Ribick, M.7    Schuit, F.C.8    Kaufman, R.J.9
  • 47
    • 55849096988 scopus 로고    scopus 로고
    • Chop deletion reduces oxidative stress, improves β cell function, and promotes cell survival in multiple mouse models of diabetes
    • Song, B., Scheuner, D., Ron, D., Pennathur, S., and Kaufman, R. J. (2008) Chop deletion reduces oxidative stress, improves β cell function, and promotes cell survival in multiple mouse models of diabetes. J. Clin. Invest. 118, 3378-3389
    • (2008) J. Clin. Invest. , vol.118 , pp. 3378-3389
    • Song, B.1    Scheuner, D.2    Ron, D.3    Pennathur, S.4    Kaufman, R.J.5
  • 48
    • 0036175128 scopus 로고    scopus 로고
    • Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes
    • DOI 10.1172/JCI200214550
    • Oyadomari, S., Koizumi, A., Takeda, K., Gotoh, T., Akira, S., Araki, E., and Mori, M. (2002) Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes. J. Clin. Invest. 109, 525-532 (Pubitemid 34171784)
    • (2002) Journal of Clinical Investigation , vol.109 , Issue.4 , pp. 525-532
    • Oyadomari, S.1    Koizumi, A.2    Takeda, K.3    Gotoh, T.4    Akira, S.5    Araki, E.6    Mori, M.7
  • 49
    • 0032693671 scopus 로고    scopus 로고
    • Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress
    • Haze, K., Yoshida, H., Yanagi, H., Yura, T., and Mori, K. (1999) Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress. Mol. Biol. Cell 10, 3787-3799 (Pubitemid 29534025)
    • (1999) Molecular Biology of the Cell , vol.10 , Issue.11 , pp. 3787-3799
    • Haze, K.1    Yoshida, H.2    Yanagi, H.3    Yura, T.4    Mori, K.5
  • 50
    • 0036069980 scopus 로고    scopus 로고
    • ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of golgi localization signals
    • DOI 10.1016/S1534-5807(02)00203-4
    • Shen, J., Chen, X., Hendershot, L., and Prywes, R. (2002) ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals. Dev. Cell 3, 99-111 (Pubitemid 34778399)
    • (2002) Developmental Cell , vol.3 , Issue.1 , pp. 99-111
    • Shen, J.1    Chen, X.2    Hendershot, L.3    Prywes, R.4
  • 51
    • 0034515724 scopus 로고    scopus 로고
    • ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs
    • DOI 10.1016/S1097-2765(00)00133-7
    • Ye, J., Rawson, R. B., Komuro, R., Chen, X., Davé, U. P., Prywes, R., Brown, M. S., and Goldstein, J. L. (2000) ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. Mol. Cell 6, 1355-1364 (Pubitemid 32045928)
    • (2000) Molecular Cell , vol.6 , Issue.6 , pp. 1355-1364
    • Ye, J.1    Rawson, R.B.2    Komuro, R.3    Chen, X.4    Dave, U.P.5    Prywes, R.6    Brown, M.S.7    Goldstein, J.L.8
  • 52
    • 0032493662 scopus 로고    scopus 로고
    • P38 mitogen-activated protein kinase mediates the transcriptional induction of the atrial natriuretic factor gene through a serum response element: A potential role for the transcription factor ATF6
    • DOI 10.1074/jbc.273.32.20636
    • Thuerauf, D. J., Arnold, N. D., Zechner, D., Hanford, D. S., DeMartin, K. M., McDonough, P. M., Prywes, R., and Glembotski, C. C. (1998) p38 mitogen-activated protein kinase mediates the transcriptional induction of the atrial natriuretic factor gene through a serum response element. A potential role for the transcription factor ATF6. J. Biol. Chem. 273, 20636-20643 (Pubitemid 28377635)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.32 , pp. 20636-20643
    • Thuerauf, D.J.1    Arnold, N.D.2    Zechner, D.3    Hanford, D.S.4    DeMartin, K.M.5    McDonough, P.M.6    Prywes, R.7    Glembotski, C.C.8
  • 54
    • 67749135249 scopus 로고    scopus 로고
    • The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis
    • Wang, Y., Vera, L., Fischer, W. H., and Montminy, M. (2009) The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis. Nature 460, 534-537
    • (2009) Nature , vol.460 , pp. 534-537
    • Wang, Y.1    Vera, L.2    Fischer, W.H.3    Montminy, M.4
  • 55
    • 34548172495 scopus 로고    scopus 로고
    • Transcriptional induction of mammalian er quality control proteins is mediated by single or combined action of atf6α and xbp1
    • DOI 10.1016/j.devcel.2007.07.018, PII S1534580707003000
    • Yamamoto, K., Sato, T., Matsui, T., Sato, M., Okada, T., Yoshida, H., Harada, A., and Mori, K. (2007) Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6α and XBP1. Dev. Cell 13, 365-376 (Pubitemid 47308680)
    • (2007) Developmental Cell , vol.13 , Issue.3 , pp. 365-376
    • Yamamoto, K.1    Sato, T.2    Matsui, T.3    Sato, M.4    Okada, T.5    Yoshida, H.6    Harada, A.7    Mori, K.8
  • 56
    • 1842509855 scopus 로고    scopus 로고
    • ATF6 modulates SREBP2-mediated lipogenesis
    • DOI 10.1038/sj.emboj.7600106
    • Zeng, L., Lu, M., Mori, K., Luo, S., Lee, A. S., Zhu, Y., and Shyy, J. Y. (2004) ATF6 modulates SREBP2-mediated lipogenesis. EMBO J. 23, 950-958 (Pubitemid 38418761)
    • (2004) EMBO Journal , vol.23 , Issue.4 , pp. 950-958
    • Zeng, L.1    Lu, M.2    Mori, K.3    Luo, S.4    Lee, A.S.5    Zhu, Y.6    Shyy, J.Y.-J.7
  • 57
    • 84864278763 scopus 로고    scopus 로고
    • Atf6α-null mice are glucose intolerant due to pancreatic β-cell failure on a high-fat diet but partially resistant to diet-induced insulin resistance
    • Usui, M., Yamaguchi, S., Tanji, Y., Tominaga, R., Ishigaki, Y., Fukumoto, M., Katagiri, H., Mori, K., Oka, Y., and Ishihara, H. (2012) Atf6α-null mice are glucose intolerant due to pancreatic β-cell failure on a high-fat diet but partially resistant to diet-induced insulin resistance. Metabolism 61, 1118-1128
    • (2012) Metabolism , vol.61 , pp. 1118-1128
    • Usui, M.1    Yamaguchi, S.2    Tanji, Y.3    Tominaga, R.4    Ishigaki, Y.5    Fukumoto, M.6    Katagiri, H.7    Mori, K.8    Oka, Y.9    Ishihara, H.10
  • 59
    • 32044453080 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response
    • DOI 10.1016/j.cell.2005.11.040, PII S0092867406000043
    • Zhang, K., Shen, X., Wu, J., Sakaki, K., Saunders, T., Rutkowski, D. T., Back, S. H., and Kaufman, R. J. (2006) Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response. Cell 124, 587-599 (Pubitemid 43199443)
    • (2006) Cell , vol.124 , Issue.3 , pp. 587-599
    • Zhang, K.1    Shen, X.2    Wu, J.3    Sakaki, K.4    Saunders, T.5    Rutkowski, D.T.6    Back, S.H.7    Kaufman, R.J.8
  • 62
    • 84856487711 scopus 로고    scopus 로고
    • Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010
    • Flegal, K. M., Carroll, M. D., Kit, B. K., and Ogden, C. L. (2012) Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010. JAMA 307, 491-497
    • (2012) JAMA , vol.307 , pp. 491-497
    • Flegal, K.M.1    Carroll, M.D.2    Kit, B.K.3    Ogden, C.L.4
  • 63
  • 65
    • 33645982255 scopus 로고    scopus 로고
    • From mice to men: Insights into the insulin resistance syndromes
    • Biddinger, S. B., and Kahn, C. R. (2006) From mice to men: insights into the insulin resistance syndromes. Annu. Rev. Physiol. 68, 123-158
    • (2006) Annu. Rev. Physiol. , vol.68 , pp. 123-158
    • Biddinger, S.B.1    Kahn, C.R.2
  • 66
    • 13944272576 scopus 로고    scopus 로고
    • The role of insulin receptor signaling in the brain
    • DOI 10.1016/j.tem.2005.01.008
    • Plum, L., Schubert, M., and Brüning, J. C. (2005) The role of insulin receptor signaling in the brain. Trends Endocrinol. Metab. 16, 59-65 (Pubitemid 40270851)
    • (2005) Trends in Endocrinology and Metabolism , vol.16 , Issue.2 , pp. 59-65
    • Plum, L.1    Schubert, M.2    Bruning, J.C.3
  • 67
    • 70349507353 scopus 로고    scopus 로고
    • Central administration of an endoplasmic reticulum stress inducer inhibits the anorexigenic effects of leptin and insulin
    • Won, J. C., Jang, P. G., Namkoong, C., Koh, E. H., Kim, S. K., Park, J. Y., Lee, K. U., and Kim, M. S. (2009) Central administration of an endoplasmic reticulum stress inducer inhibits the anorexigenic effects of leptin and insulin. Obesity 17, 1861-1865
    • (2009) Obesity , vol.17 , pp. 1861-1865
    • Won, J.C.1    Jang, P.G.2    Namkoong, C.3    Koh, E.H.4    Kim, S.K.5    Park, J.Y.6    Lee, K.U.7    Kim, M.S.8
  • 68
    • 33748069813 scopus 로고    scopus 로고
    • Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
    • DOI 10.1126/science.1128294
    • Ozcan, U., Yilmaz, E., Ozcan, L., Furuhashi, M., Vaillancourt, E., Smith, R. O., Görgün, C. Z., and Hotamisligil, G. S. (2006) Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 313, 1137-1140 (Pubitemid 44300242)
    • (2006) Science , vol.313 , Issue.5790 , pp. 1137-1140
    • Ozcan, U.1    Yilmaz, E.2    Ozcan, L.3    Furuhashi, M.4    Vaillancourt, E.5    Smith, R.O.6    Gorgun, C.Z.7    Hotamisligil, G.S.8
  • 70
    • 79952410092 scopus 로고    scopus 로고
    • Sodium phenylbutyrate, a drug with known capacity to reduce endoplasmic reticulum stress, partially alleviates lipid-induced insulin resistance and β-cell dysfunction in humans
    • Xiao, C., Giacca, A., and Lewis, G. F. (2011) Sodium phenylbutyrate, a drug with known capacity to reduce endoplasmic reticulum stress, partially alleviates lipid-induced insulin resistance and β-cell dysfunction in humans. Diabetes 60, 918-924
    • (2011) Diabetes , vol.60 , pp. 918-924
    • Xiao, C.1    Giacca, A.2    Lewis, G.F.3
  • 73
    • 78650615554 scopus 로고    scopus 로고
    • Sarco(endo)plasmic reticulum Ca2+-ATPase 2b is a major regulator of endoplasmic reticulum stress and glucose homeostasis in obesity
    • Park, S. W., Zhou, Y., Lee, J., and Ozcan, U. (2010) Sarco(endo)plasmic reticulum Ca2+-ATPase 2b is a major regulator of endoplasmic reticulum stress and glucose homeostasis in obesity. Proc. Natl. Acad. Sci. U.S.A. 107, 19320-19325
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 19320-19325
    • Park, S.W.1    Zhou, Y.2    Lee, J.3    Ozcan, U.4
  • 74
    • 84866596196 scopus 로고    scopus 로고
    • ImpairedMEK signaling and SERCA expression promote ER stress and apoptosis in insulin-resistant macrophages and are reversed by exenatide treatment
    • Liang, C. P., Han, S., Li, G., Tabas, I., and Tall, A. R. (2012) ImpairedMEK signaling and SERCA expression promote ER stress and apoptosis in insulin-resistant macrophages and are reversed by exenatide treatment. Diabetes 61, 2609-2620
    • (2012) Diabetes , vol.61 , pp. 2609-2620
    • Liang, C.P.1    Han, S.2    Li, G.3    Tabas, I.4    Tall, A.R.5
  • 75
    • 84859778293 scopus 로고    scopus 로고
    • MTOR signaling in growth control and disease
    • Laplante, M., and Sabatini, D. M. (2012) mTOR signaling in growth control and disease. Cell 149, 274-293
    • (2012) Cell , vol.149 , pp. 274-293
    • Laplante, M.1    Sabatini, D.M.2
  • 76
    • 40649104735 scopus 로고    scopus 로고
    • Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis
    • DOI 10.1016/j.molcel.2007.12.023, PII S109727650800066X
    • Ozcan, U., Ozcan, L., Yilmaz, E., Düvel, K., Sahin, M., Manning, B. D., and Hotamisligil, G. S. (2008) Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis. Mol. Cell 29, 541-551 (Pubitemid 351384644)
    • (2008) Molecular Cell , vol.29 , Issue.5 , pp. 541-551
    • Ozcan, U.1    Ozcan, L.2    Yilmaz, E.3    Duvel, K.4    Sahin, M.5    Manning, B.D.6    Hotamisligil, G.S.7
  • 77
    • 66449137379 scopus 로고    scopus 로고
    • GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice
    • Kammoun, H. L., Chabanon, H., Hainault, I., Luquet, S., Magnan, C., Koike, T., Ferré, P., and Foufelle, F. (2009) GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice. J. Clin. Invest. 119, 1201-1215
    • (2009) J. Clin. Invest. , vol.119 , pp. 1201-1215
    • Kammoun, H.L.1    Chabanon, H.2    Hainault, I.3    Luquet, S.4    Magnan, C.5    Koike, T.6    Ferré, P.7    Foufelle, F.8
  • 80
    • 0037960128 scopus 로고    scopus 로고
    • Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice
    • DOI 10.1016/S0016-5085(03)00276-2
    • Ji, C., and Kaplowitz, N. (2003) Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice. Gastroenterology 124, 1488-1499 (Pubitemid 36531821)
    • (2003) Gastroenterology , vol.124 , Issue.5 , pp. 1488-1499
    • Ji, C.1    Kaplowitz, N.2
  • 81
    • 24144472287 scopus 로고    scopus 로고
    • Role of CHOP in hepatic apoptosis in the murine model of intragastric ethanol feeding
    • DOI 10.1097/01.alc.0000174691.03751.11
    • Ji, C., Mehrian-Shai, R., Chan, C., Hsu, Y. H., and Kaplowitz, N. (2005) Role of CHOP in hepatic apoptosis in the murine model of intragastric ethanol feeding. Alcohol. Clin. Exp. Res. 29, 1496-1503 (Pubitemid 41243375)
    • (2005) Alcoholism: Clinical and Experimental Research , vol.29 , Issue.8 , pp. 1496-1503
    • Ji, C.1    Mehrian-Shai, R.2    Chan, C.3    Hsu, Y.-H.4    Kaplowitz, N.5
  • 82
    • 49149090637 scopus 로고    scopus 로고
    • Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress
    • Bochkis, I. M., Rubins, N. E., White, P., Furth, E. E., Friedman, J. R., and Kaestner, K. H. (2008) Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress. Nat. Med. 14, 828-836
    • (2008) Nat. Med. , vol.14 , pp. 828-836
    • Bochkis, I.M.1    Rubins, N.E.2    White, P.3    Furth, E.E.4    Friedman, J.R.5    Kaestner, K.H.6
  • 84
    • 79955535643 scopus 로고    scopus 로고
    • Macrophages in the pathogenesis of atherosclerosis
    • Moore, K. J., and Tabas, I. (2011) Macrophages in the pathogenesis of atherosclerosis. Cell 145, 341-355
    • (2011) Cell , vol.145 , pp. 341-355
    • Moore, K.J.1    Tabas, I.2
  • 85
    • 79955025433 scopus 로고    scopus 로고
    • A reporter for tracking the UPR in vivo reveals patterns of temporal and cellular stress during atherosclerotic progression
    • Thorp, E., Iwawaki, T., Miura, M., and Tabas, I. (2011) A reporter for tracking the UPR in vivo reveals patterns of temporal and cellular stress during atherosclerotic progression. J. Lipid Res. 52, 1033-1038
    • (2011) J. Lipid Res. , vol.52 , pp. 1033-1038
    • Thorp, E.1    Iwawaki, T.2    Miura, M.3    Tabas, I.4
  • 86
    • 84879411171 scopus 로고    scopus 로고
    • Palmitate induces apoptosis in mouse aortic endothelial cells and endothelial dysfunction in mice fed high-calorie and high-cholesterol diets
    • Lu, Y., Qian, L., Zhang, Q., Chen, B., Gui, L., Huang, D., Chen, G., and Chen, L. (2013) Palmitate induces apoptosis in mouse aortic endothelial cells and endothelial dysfunction in mice fed high-calorie and high-cholesterol diets. Life Sci. 92, 1165-1173
    • (2013) Life Sci. , vol.92 , pp. 1165-1173
    • Lu, Y.1    Qian, L.2    Zhang, Q.3    Chen, B.4    Gui, L.5    Huang, D.6    Chen, G.7    Chen, L.8
  • 87
    • 0029860742 scopus 로고    scopus 로고
    • Homocysteine-respondent genes in vascular endothelial cells identified by differential display analysis: GRP78/BiP and novel genes
    • DOI 10.1074/jbc.271.47.29659
    • Kokame, K., Kato, H., and Miyata, T. (1996) Homocysteine-respondent genes in vascular endothelial cells identified by differential display analysis. GRP78/BiP and novel genes. J. Biol. Chem. 271, 29659-29665 (Pubitemid 26389590)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.47 , pp. 29659-29665
    • Kokame, K.1    Kato, H.2    Miyata, T.3
  • 88
    • 41049092083 scopus 로고    scopus 로고
    • Free cholesterol-induced macrophage apoptosis is mediated by inositol-requiring enzyme 1 alpha-regulated activation of Jun N-terminal kinase
    • DOI 10.1111/j.1745-7270.2008.00396.x
    • Li, F., Guo, Y., Sun, S., Jiang, X., Tang, B., Wang, Q., and Wang, L. (2008) Free cholesterol-induced macrophage apoptosis is mediated by inositolrequiring enzyme 1 α-regulated activation of Jun N-terminal kinase. Acta Biochim. Biophys. Sin. 40, 226-234 (Pubitemid 351422576)
    • (2008) Acta Biochimica et Biophysica Sinica , vol.40 , Issue.3 , pp. 226-234
    • Li, F.1    Guo, Y.2    Sun, S.3    Jiang, X.4    Tang, B.5    Wang, Q.6    Wang, L.7
  • 89
    • 65349135431 scopus 로고    scopus 로고
    • Reduced apoptosis and plaque necrosis in advanced atherosclerotic lesions of Apoe-/- and Ldlr-/- mice lacking CHOP
    • Thorp, E., Li, G., Seimon, T. A., Kuriakose, G., Ron, D., and Tabas, I. (2009) Reduced apoptosis and plaque necrosis in advanced atherosclerotic lesions of Apoe-/- and Ldlr-/- mice lacking CHOP. Cell Metab. 9, 474-481
    • (2009) Cell Metab. , vol.9 , pp. 474-481
    • Thorp, E.1    Li, G.2    Seimon, T.A.3    Kuriakose, G.4    Ron, D.5    Tabas, I.6
  • 90
    • 40649112123 scopus 로고    scopus 로고
    • The role of the unfolded protein response in the heart
    • DOI 10.1016/j.yjmcc.2007.10.017, PII S0022282807012837
    • Glembotski, C. C. (2008) The role of the unfolded protein response in the heart. J. Mol. Cell. Cardiol. 44, 453-459 (Pubitemid 351374700)
    • (2008) Journal of Molecular and Cellular Cardiology , vol.44 , Issue.3 , pp. 453-459
    • Glembotski, C.C.1
  • 91
    • 33745019669 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress gene induction and protection from ischemia/reperfusion injury in the hearts of transgenic mice with a tamoxifen-regulated form of ATF6
    • DOI 10.1161/01.RES.0000220643.65941.8d, PII 0000301220060512000014
    • Martindale, J. J., Fernandez, R., Thuerauf, D., Whittaker, R., Gude, N., Sussman, M. A., and Glembotski, C. C. (2006) Endoplasmic reticulum stress gene induction and protection from ischemia/reperfusion injury in the hearts of transgenic mice with a tamoxifen-regulated form of ATF6. Circ. Res. 98, 1186-1193 (Pubitemid 43948105)
    • (2006) Circulation Research , vol.98 , Issue.9 , pp. 1186-1193
    • Martindale, J.J.1    Fernandez, R.2    Thuerauf, D.3    Whittaker, R.4    Gude, N.5    Sussman, M.A.6    Glembotski, C.C.7
  • 92
    • 0041568574 scopus 로고    scopus 로고
    • Induction of GRP78 by ischemic preconditioning reduces endoplasmic reticulum stress and prevents delayed neuronal cell death
    • Hayashi, T., Saito, A., Okuno, S., Ferrand-Drake, M., and Chan, P. H. (2003) Induction of GRP78 by ischemic preconditioning reduces endoplasmic reticulum stress and prevents delayed neuronal cell death. J. Cereb. Blood Flow Metab. 23, 949-961 (Pubitemid 36959401)
    • (2003) Journal of Cerebral Blood Flow and Metabolism , vol.23 , Issue.8 , pp. 949-961
    • Hayashi, T.1    Saito, A.2    Okuno, S.3    Ferrand-Drake, M.4    Chan, P.H.5
  • 93
    • 1842854719 scopus 로고    scopus 로고
    • Ischemia-induced neuronal cell death is mediated by the endoplasmic reticulum stress pathway involving CHOP
    • DOI 10.1038/sj.cdd.4401365
    • Tajiri, S., Oyadomari, S., Yano, S., Morioka, M., Gotoh, T., Hamada, J. I., Ushio, Y., and Mori, M. (2004) Ischemia-induced neuronal cell death is mediated by the endoplasmic reticulum stress pathway involving CHOP. Cell Death Differ. 11, 403-415 (Pubitemid 38489418)
    • (2004) Cell Death and Differentiation , vol.11 , Issue.4 , pp. 403-415
    • Tajiri, S.1    Oyadomari, S.2    Yano, S.3    Morioka, M.4    Gotoh, T.5    Hamada, J.-I.6    Ushio, Y.7    Mori, M.8
  • 95
    • 84871940845 scopus 로고    scopus 로고
    • Development of proteasome inhibitors as research tools and cancer drugs
    • Goldberg, A. L. (2012) Development of proteasome inhibitors as research tools and cancer drugs. J. Cell Biol. 199, 583-588
    • (2012) J. Cell Biol. , vol.199 , pp. 583-588
    • Goldberg, A.L.1
  • 98
    • 84871759394 scopus 로고    scopus 로고
    • Uncoupling proteostasis and development in vitro with a small molecule inhibitor of the pancreatic endoplasmic reticulum kinase, PERK
    • Harding, H. P., Zyryanova, A. F., and Ron, D. (2012) Uncoupling proteostasis and development in vitro with a small molecule inhibitor of the pancreatic endoplasmic reticulum kinase, PERK. J. Biol. Chem. 287, 44338-44344
    • (2012) J. Biol. Chem. , vol.287 , pp. 44338-44344
    • Harding, H.P.1    Zyryanova, A.F.2    Ron, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.