MRNA-based therapeutics-developing a new class of drugs

Nature Reviews Drug Discovery

Volumn 13, Issue 10, 2014, Pages 759-780

  Sahin, Ugur ^a,b   Karikó, Katalin ^b,c   Türeci, Özlem ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b BIONTECH AG   (Germany)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DENDRITIC CELL VACCINE; IN VITRO TRANSCRIBED MRNA; MESSENGER RNA; MRNA VACCINE; PLASMID DNA; POLYADENYLATED RNA; RNA VACCINE; UNCLASSIFIED DRUG; PROTEIN;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ADVANCED CANCER; ALLERGY; ANEMIA; ANTIBODY RESPONSE; ASTHMA; BIOLOGICAL THERAPY; CANCER IMMUNOTHERAPY; CELL FATE; CLINICAL TRIAL (TOPIC); CODON; CONGENITAL LUNG DISEASE; DIABETES INSIPIDUS; DIABETES MELLITUS; DRUG ACTIVITY; DRUG DESIGN; DRUG HALF LIFE; DRUG MECHANISM; DRUG SAFETY; DRUG SYNTHESIS; ELECTROPORATION; GENETIC ENGINEERING; GENETIC STABILITY; HEMATOLOGIC MALIGNANCY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOGENICITY; IMMUNOSTIMULATION; IN VITRO GENE TRANSFER; IN VIVO GENE TRANSFER; INFLAMMATION; INFLUENZA; KIDNEY CARCINOMA; LEUKEMIA; LYMPHOMA; MELANOMA; MESOTHELIOMA; MYOCARDITIS; NONHUMAN; OVARY CANCER; PANCREAS CANCER; PHARMACODYNAMICS; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN REPLACEMENT THERAPY; RESPIRATORY TRACT INFECTION; REVIEW; RNA EDITING; RNA TRANSLATION; STRUCTURE ACTIVITY RELATION; TH2 CELL; TICK BORNE ENCEPHALITIS; TRANSIENT EXPRESSION; TUBERCULOSIS; ANIMAL; DRUG DELIVERY SYSTEM; IMMUNOTHERAPY; METABOLISM; PROCEDURES;

ANIMALS; DRUG DELIVERY SYSTEMS; DRUG DESIGN; HUMANS; IMMUNOTHERAPY; PLURIPOTENT STEM CELLS; PROTEINS; RNA, MESSENGER;

EID: 84921794613     PISSN: 14741776     EISSN: 14741784     Source Type: Journal    
DOI: 10.1038/nrd4278     Document Type: Review

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