Expression of therapeutic proteins after delivery of chemically modified mRNA in mice

Nature Biotechnology

Volumn 29, Issue 2, 2011, Pages 154-159

  Kormann, Michael S D ^a,b   Hasenpusch, Günther ^a   Aneja, Manish K ^a   Nica, Gabriela ^a   Flemmer, Andreas W ^a   Herber Jonat, Susanne ^a   Huppmann, Marceline ^a   Mays, Lauren E ^b   Illenyi, Marta ^a   Schams, Andrea ^a   Griese, Matthias ^a   Bittmann, Iris ^c   Handgretinger, Rupert ^b   Hartl, Dominik ^b   Rosenecker, Joseph ^a   Rudolph, Carsten ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c Diakonien Hospital Rotenburg Wümme LTD   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICALLY MODIFIED; IMMUNOGENICITY; INTRAMUSCULAR INJECTIONS; LEUKEMOGENESIS; LUNG DISEASE; MOUSE MODELS; NONVIRAL VECTORS; SAFETY CONCERNS; SURFACTANT PROTEIN B; THERAPEUTIC PROTEIN; TOLL-LIKE RECEPTORS; TRANSFER EFFICIENCY; VIRAL VECTORS; WILD TYPES;

BIOLOGICAL ORGANS; GENE TRANSFER; NUCLEIC ACIDS; PULMONARY DISEASES; SURFACE ACTIVE AGENTS;

GENE THERAPY;

DNA; ERYTHROPOIETIN; MESSENGER RNA; SURFACTANT PROTEIN B; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; GENE; GENE THERAPY; HEMATOCRIT; IMMUNOGENICITY; LUNG DISEASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETINOID INDUCIBLE GENE I;

ANIMALS; ERYTHROPOIETIN; GENE TRANSFER TECHNIQUES; HISTOCYTOCHEMISTRY; KAPLAN-MEIER ESTIMATE; LUNG; MICE; MICE, TRANSGENIC; PROTEOLIPIDS; RNA STABILITY; RNA, MESSENGER;

MURINAE; MUS;

EID: 79751497093     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt.1733     Document Type: Article

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