Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction

Nature Biotechnology

Volumn 31, Issue 10, 2013, Pages 898-907

  Zangi, Lior ^a,b,c,d   Lui, Kathy O ^a,b,e   Von Gise, Alexander ^c,d   Ma, Qing ^c,d   Ebina, Wataru ^a,c   Ptaszek, Leon M ^a,b   Später, Daniela ^a,b   Xu, Huansheng ^a,b,e   Tabebordbar, Mohammadsharif ^a,f   Gorbatov, Rostic ^b   Sena, Brena ^b   Nahrendorf, Matthias ^b   Briscoe, David M ^c   Li, Ronald A ^e,g   Wagers, Amy J ^a,h   Rossi, Derrick J ^a,c   Pu, William T ^c,d   Chien, Kenneth R ^a,b,i  

^a Harvard University   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c BOSTON CHILDREN S HOSPITAL   (United States)

^d HARVARD STEM CELL INSTITUTE   (United States)

^e UNIVERSITY OF HONG KONG   (Hong Kong)

^f HARVARD MEDICAL SCHOOL   (United States)

^g MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^h HOWARD HUGHES MEDICAL INSTITUTE   (United States)

ⁱ KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CELL TYPES; DIRECTED DIFFERENTIATIONS; DNA VECTORS; HEART FUNCTION; MYOCARDIAL INFARCTION; PROGENITOR CELL; TEMPORAL CONTROLS; VASCULAR ENDOTHELIAL GROWTH FACTOR-A;

CYTOLOGY; ENDOTHELIAL CELLS; RNA;

CELL ENGINEERING;

BEVACIZUMAB; MESSENGER RNA; MODIFIED RNA; RECOMBINANT RNA; RECOMBINANT VASCULOTROPIN; RECOMBINANT VASCULOTROPIN A; UNCLASSIFIED DRUG; VASCULOTROPIN A; VASCULOTROPIN INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL EXPANSION; CELL FATE; CELL REGENERATION; CELL TYPE; CONTROLLED STUDY; DNA VECTOR; DRUG EFFICACY; FEMALE; GENE DELIVERY SYSTEM; GRAFT RECIPIENT; HEART FUNCTION; HEART INFARCTION; HEART MUSCLE CELL; HEART PROGENITOR CELL; IN VITRO STUDY; IN VIVO STUDY; LONG TERM SURVIVAL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; STEM CELL; STEM CELL MOBILIZATION; STEM CELL TRANSPLANTATION;

ANIMALS; APOPTOSIS; BIOLOGICAL MARKERS; CELL DIFFERENTIATION; CELL LINEAGE; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; GENE TRANSFER TECHNIQUES; HUMANS; KINETICS; LUCIFERASES; MICE; MODELS, BIOLOGICAL; MUSCLE, SKELETAL; MYOCARDIAL INFARCTION; MYOCARDIUM; REGENERATION; RNA, MESSENGER; STEM CELL TRANSPLANTATION; STEM CELLS; SURVIVAL ANALYSIS; TREATMENT OUTCOME; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 84885676364     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt.2682     Document Type: Article

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