Characterization of CD 8 + T-Cell responses in the peripheral blood and skin injection sites of melanoma patients treated with mRNA electroporated autologous dendritic cells (TriMixDC-MEL)

BioMed Research International

Volumn 2013, Issue , 2013, Pages

  Benteyn, Daphné ^a   Van Nuffel, An M T ^a   Wilgenhof, Sofie ^a,b   Corthals, Jurgen ^a   Heirman, Carlo ^a   Neyns, Bart ^a,b   Thielemans, Kris ^a,b   Bonehill, Aude ^a  

^a VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^b UNIVERSITY HOSPITAL BRUSSELS   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CD137 ANTIGEN; DENDRITIC CELL VACCINE; GAMMA INTERFERON; MRNA ELECTROPORATED DENDRITIC CELL VACCINE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CANCER VACCINE; EPITOPE; TUMOR ANTIGEN;

ANTIGEN PRESENTATION; ANTIGEN SPECIFICITY; ARTICLE; CD8+ T LYMPHOCYTE; CELL COMPARTMENTALIZATION; CELL EXPANSION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXIC T LYMPHOCYTE; DELAYED HYPERSENSITIVITY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INJECTION SITE; LYMPHOCYTE MIGRATION; MELANOMA; METASTASIS; PATIENT MONITORING; PERIPHERAL LYMPHOCYTE; SKIN BIOPSY; UPREGULATION; BIOPSY; CELL MOTION; CLINICAL TRIAL; DENDRITIC CELL; ELECTROPORATION; IMMUNOLOGY; METABOLISM; PILOT STUDY; RECURRENT DISEASE; SKIN; SKIN TUMOR; TRANSPLANTATION;

ANTIGENS, NEOPLASM; BIOPSY; CANCER VACCINES; CD8-POSITIVE T-LYMPHOCYTES; CELL MOVEMENT; DENDRITIC CELLS; ELECTROPORATION; EPITOPES; HUMANS; MELANOMA; NEOPLASM METASTASIS; PILOT PROJECTS; RECURRENCE; SKIN; SKIN NEOPLASMS;

EID: 84874640769     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2013/976383     Document Type: Article

References (24)

1. + T cells in melanoma patients. Molecular Therapy 2012 20 5 1063 1074 10.1038/mt.2012.11
2. van Tendeloo V. F., van de Veldea A., van Driesschea A., Coolsa N., Anguille S., Ladell K., Gostick E., Vermeulen K., Pieters K., Nijs G., Stein B., Smits E. L., Schroyens W. A., Gadisseur A. P., Vrelust I., Jorens P. G., Goossens H., De Vries I. J., Price D. A., Oji Y., Oka Y., Sugiyama H., Berneman Z. N., Induction of complete and molecular remissions in acute myeloid leukemia by Wilms' tumor 1 antigen-targeted dendritic cell vaccination. Proceedings of the National Academy of Sciences of the United States of America 2010 107 31 13824 13829 2-s2.0-77956384935 10.1073/pnas.1008051107
3. van Nuffel A. M., Benteyn D., Wilgenhof S., Intravenous and intradermal TriMix-dendritic cell therapy results in a broad T-cell response and durable tumor response in a chemorefractory stage IV-M1c melanoma patient. Cancer Immunology, Immunotherapy 2012 61 7 1033 1043 10.1007/s00262-011-1176-2
4. Bonehill A., van Nuffel A. M. T., Corthals J., Tuyaerts S., Heirman C., François V., Colau D., Van Der Bruggen P., Neyns B., Thielemans K., Single-step antigen loading and activation of dendritic cells by mRNA electroporation for the purpose of therapeutic vaccination in melanoma patients. Clinical Cancer Research 2009 15 10 3366 3375 2-s2.0-66149186858 10.1158/1078-0432.CCR-08-2982
5. Tjin E. P. M., Konijnenberg D., Krebbers G., Mallo H., Drijfhout J. W., Franken K. L. M. C., van der Horst C. M. A. M., Bos J. D., Nieweg O. E., Kroon B. B. R., Haanen J. B. A. G., Melief C. J. M., Vyth-Dreese F. A., Luiten R. M., T-cell immune function in tumor, skin, and peripheral blood of advanced stage melanoma patients: implications for immunotherapy. Clinical Cancer Research 2011 17 17 5736 5747 2-s2.0-80052432557 10.1158/1078-0432.CCR-11-0230
6. Suso E. M. I., Dueland S., Rasmussen A. M., Vetrhus T., Aamdal S., Kvalheim G., Gaudernack G., HTERT mRNA dendritic cell vaccination: complete response in a pancreatic cancer patient associated with response against several hTERT epitopes. Cancer Immunology, Immunotherapy 2011 60 6 809 818 2-s2.0-79959769072 10.1007/s00262-011-0991-9
7. de Vries I. J. M., Bernsen M. R., Lesterhuis W. J., Scharenborg N. M., Strijk S. P., Gerritsen M. J. P., Ruiter D. J., Figdor C. G., Punt C. J. A., Adema G. J., Immunomonitoring tumor-specific T cells in delayed-type hypersensitivity skin biopsies after dendritic cell vaccination correlates with clinical outcome. Journal of Clinical Oncology 2005 23 24 5779 5787 2-s2.0-24944546501 10.1200/JCO.2005.06.478
8. van Nuffel A. M., Tuyaerts S., Benteyn D., Epitope and HLA-type independent monitoring of antigen-specific T-cells after treatment with dendritic cells presenting full-length tumor antigens. Journal of Immunological Methods 2012 377 1-2 23 36 10.1016/j.jim.2011.12.010
9. van Lint S., Goyvaerts C., Maenhout S., Goethals L., Disy A., Benteyn D., Pen J., Bonehill A., Heirman C., Breckpot K., Thielemans K., Preclinical evaluation of TriMix and antigen mRNA-based antitumor therapy. Cancer Research 2012 72 7 1661 1671 2-s2.0-84859417996 10.1158/0008-5472.CAN-11-2957
10. Wilgenhof S., van Nuffel A. M. T., Corthals J., Heirman C., Tuyaerts S., Benteyn D., de Coninck A., van Riet I., Verfaillie G., Vandeloo J., Bonehill A., Thielemans K., Neyns B., Therapeutic vaccination with an autologous mRNA electroporated dendritic cell vaccine in patients with advanced melanoma. Journal of Immunotherapy 2011 34 5 448 456 2-s2.0-79957904174 10.1097/CJI.0b013e31821dcb31
11. van Nuffel A. M., Corthals J., Neyns B., Heirman C., Thielemans K., Bonehill A., Immunotherapy of cancer with dendritic cells loaded with tumor antigens and activated through mRNA electroporation. Methods in Molecular Biology 2010 629 405 452 2-s2.0-77954050387 10.1007/978-1-60761-657-3-27
12. Bonehill A., van Nuffel A. M. T., Corthals J., Tuyaerts S., Heirman C., François V., Colau D., Van Der Bruggen P., Neyns B., Thielemans K., Single-step antigen loading and activation of dendritic cells by mRNA electroporation for the purpose of therapeutic vaccination in melanoma patients. Clinical Cancer Research 2009 15 10 3366 3375 2-s2.0-66149186858 10.1158/1078-0432.CCR-08-2982
13. Brunsvig P. F., Aamdal S., Gjertsen M. K., Kvalheim G., Markowski-Grimsrud C. J., Sve I., Dyrhaug M., Trachsel S., Møller M., Eriksen J. A., Gaudernack G., Telomerase peptide vaccination: a phase I/II study in patients with non-small cell lung cancer. Cancer Immunology, Immunotherapy 2006 55 12 1553 1564 2-s2.0-33745638729 10.1007/s00262-006-0145-7 (Pubitemid 44327843)
14. Hunger R. E., Kernland Lang K., Markowski C. J., Trachsel S., Møller M., Eriksen J. A., Rasmussen A. M., Braathen L. R., Gaudernack G., Vaccination of patients with cutaneous melanoma with telomerase-specific peptides. Cancer Immunology, Immunotherapy 2011 60 11 1553 1564 2-s2.0-79959279787 10.1007/s00262-011-1061-z
15. Lesterhuis W. J., de Vries I. J. M., Schuurhuis D. H., Boullart A. C. I., Jacobs J. F. M., de Boer A. J., Scharenborg N. M., Brouwer H. M. H., van de Rakt M. W. M. M., Figdor C. G., Ruers T. J., Adema G. J., Punt C. J. A., Vaccination of colorectal cancer patients with CEA-loaded dendritic cells: antigen-specific T cell responses in DTH skin tests. Annals of Oncology 2006 17 6 974 980 2-s2.0-33646863192 10.1093/annonc/mdl072 (Pubitemid 43778989)
16. Lesterhuis W. J., Schreibelt G., Scharenborg N. M., Brouwer H. M. L. H., Gerritsen M. J. P., Croockewit S., Coulie P. G., Torensma R., Adema G. J., Figdor C. G., De Vries I. J. M., Punt C. J. A., Wild-type and modified gp100 peptide-pulsed dendritic cell vaccination of advanced melanoma patients can lead to long-term clinical responses independent of the peptide used. Cancer Immunology, Immunotherapy 2011 60 2 249 260 2-s2.0-79151468702 10.1007/s00262-010-0942-x
17. Bonehill A., Tuyaerts S., van Nuffel A. M. T., Heirman C., Bos T. J., Fostier K., Neyns B., Thielemans K., Enhancing the t-cell stimulatory capacity of human dendritic cells by co-electroporation with CD40L, CD70 and constitutively active TLR4 encoding mRNA. Molecular Therapy 2008 16 6 1170 1180 2-s2.0-44349173032 10.1038/mt.2008.77 (Pubitemid 351737084)
18. Mullins D. W., Sheasley S. L., Ream R. M., Bullock T. N. J., Fu Y. X., Engelhard V. H. C.-P., Route of immunization with peptide-pulsed dendritic cells controls the distribution of memory and effector T cells in lymphoid tissues and determines the pattern of regional tumor control. Journal of Experimental Medicine 2003 198 7 1023 1034 2-s2.0-0141993954 10.1084/jem.20021348 (Pubitemid 37248618)
19. Ferguson A. R., Engelhard V. H. C.-P., CD8 T cells activated in distinct lymphoid organs differentially express adhesion proteins and coexpress multiple chemokine receptors. Journal of Immunology 2010 184 8 4079 4086 2-s2.0-77952777105 10.4049/jimmunol.0901903
20. Ferguson A. R., Nichols L. A., Zarling A. L., Thompson E. D., Brinkman C. C., Hargadon K. M., Bullock T. N., Engelhard V. H., Strategies and challenges in eliciting immunity to melanoma. Immunological Reviews 2008 222 1 28 42 2-s2.0-41149175659 10.1111/j.1600-065X.2008.00620.x (Pubitemid 351430382)
21. + T cell responses. Cancer Immunology, Immunotherapy 2010 59 9 1425 1433 2-s2.0-77955514114 10.1007/s00262-010-0824-2
22. Andersen R. S., Kvistborg P., Frøsig T. M., Parallel detection of antigen-specific T cell responses by combinatorial encoding of MHC multimers. Nature Protocols 2012 7 891 902 10.1038/nprot.2012.037
23. + T-cells specific for different islet cell-associated epitopes using combinatorial MHC multimers. Diabetes 2010 59 7 1721 1730 2-s2.0-77951983004 10.2337/db09-1486
24. van der Bruggen P. S., Vigneron N., van den Eynde B., Peptide Database. http://cancerimmunity.org/peptide/