-
1
-
-
77957242130
-
Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation
-
Anderson, B., Muramatsu, H., Nallagatla, S., Bevilacqua, P., Sansing, L., Weissman, D. et al. (2010) Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation. Nucleic Acids Res 38: 5884–5892
-
(2010)
Nucleic Acids Res
, vol.38
, pp. 5884-5892
-
-
Anderson, B.1
Muramatsu, H.2
Nallagatla, S.3
Bevilacqua, P.4
Sansing, L.5
Weissman, D.6
-
2
-
-
0036196564
-
Kunjin virus replicon vaccine vectors induce protective CD8+ T-cell immunity
-
Anraku, I., Harvey, T., Linedale, R., Gardner, J., Harrich, D., Suhrbier, A. et al. (2002) Kunjin virus replicon vaccine vectors induce protective CD8+ T-cell immunity. J Virol 76: 3791–3799
-
(2002)
J Virol
, vol.76
, pp. 3791-3799
-
-
Anraku, I.1
Harvey, T.2
Linedale, R.3
Gardner, J.4
Harrich, D.5
Suhrbier, A.6
-
3
-
-
80053353462
-
Innate and adaptive immune responses to viral infection and vaccination
-
Aoshi, T., Koyama, S., Kobiyama, K., Akira, S. and Ishii, K.J. (2011) Innate and adaptive immune responses to viral infection and vaccination. Curr Opin Virol 1: 226–232
-
(2011)
Curr Opin Virol
, vol.1
, pp. 226-232
-
-
Aoshi, T.1
Koyama, S.2
Kobiyama, K.3
Akira, S.4
Ishii, K.J.5
-
4
-
-
84867437406
-
Immunotherapy against HPV16/18 generates potent TH1 and cytotoxic cellular immune responses
-
Bagarazzi, M., Yan, J., Morrow, M., Shen, X., Parker, R., Lee, J. et al. (2012) Immunotherapy against HPV16/18 generates potent TH1 and cytotoxic cellular immune responses. Sci Transl Med 4: 155ra138
-
(2012)
Sci Transl Med
, vol.4
-
-
Bagarazzi, M.1
Yan, J.2
Morrow, M.3
Shen, X.4
Parker, R.5
Lee, J.6
-
5
-
-
0019276997
-
5′-terminal cap structure in eucaryotic messenger ribonucleic acids
-
Banerjee, A. (1980) 5′-terminal cap structure in eucaryotic messenger ribonucleic acids. Microbiol Rev 44: 175–205
-
(1980)
Microbiol Rev
, vol.44
, pp. 175-205
-
-
Anerjee, A.1
-
6
-
-
49649120397
-
Tumor regression in cancer patients by very low doses of a T cell-engaging antibody
-
Bargou, R., Leo, E., Zugmaier, G., Klinger, M., Goebeler, M., Knop, S. et al. (2008) Tumor regression in cancer patients by very low doses of a T cell-engaging antibody. Science 321: 974–977
-
(2008)
Science
, vol.321
, pp. 974-977
-
-
Bargou, R.1
Leo, E.2
Zugmaier, G.3
Klinger, M.4
Goebeler, M.5
Knop, S.6
-
7
-
-
33745370080
-
Generation of hypoallergenic DNA vaccines by forced ubiquitination: Preventive and therapeutic effects in a mouse model of allergy
-
Bauer, R., Scheiblhofer, S., Kern, K., Gruber, C., Stepanoska, T., Thalhamer, T. et al. (2006) Generation of hypoallergenic DNA vaccines by forced ubiquitination: preventive and therapeutic effects in a mouse model of allergy. J Allergy Clin Immunol 118: 269–276
-
(2006)
J Allergy Clin Immunol
, vol.118
, pp. 269-276
-
-
Bauer, R.1
Scheiblhofer, S.2
Kern, K.3
Gruber, C.4
Stepanoska, T.5
Thalhamer, T.6
-
8
-
-
77952238515
-
A phase 2 study of high-dose Allovectin-7 in patients with advanced metastatic melanoma
-
Bedikian, A., Richards, J., Kharkevitch, D., Atkins, M., Whitman, E. and Gonzalez, R. (2010) A phase 2 study of high-dose Allovectin-7 in patients with advanced metastatic melanoma. Melanoma Res 20: 218–226
-
(2010)
Melanoma Res
, vol.20
, pp. 218-226
-
-
Bedikian, A.1
Richards, J.2
Kharkevitch, D.3
Atkins, M.4
Whitman, E.5
Gonzalez, R.6
-
9
-
-
84870455276
-
Anti-TNF-alpha biotherapies: Perspectives for evidence-based personalized medicine
-
Bendtzen, K. (2012) Anti-TNF-alpha biotherapies: perspectives for evidence-based personalized medicine. Immunotherapy 4: 1167–1179
-
(2012)
Immunotherapy
, vol.4
, pp. 1167-1179
-
-
Bendtzen, K.1
-
10
-
-
84874640769
-
Characterization of CD8+ T-cell responses in the peripheral blood and skin injection sites of melanoma patients treated with mRNA electroporated autologous dendritic cells (TriMixDC-MEL)
-
Benteyn, D., Van Nuffel, A., Wilgenhof, S., Corthals, J., Heirman, C., Neyns, B. et al. (2013) Characterization of CD8+ T-cell responses in the peripheral blood and skin injection sites of melanoma patients treated with mRNA electroporated autologous dendritic cells (TriMixDC-MEL). Biomed Res Int 2013: 976383
-
(2013)
Biomed Res Int
, vol.2013
-
-
Benteyn, D.1
Van Nuffel, A.2
Wilgenhof, S.3
Corthals, J.4
Heirman, C.5
Neyns, B.6
-
11
-
-
0033524647
-
Immunization with recombinant Semliki Forest virus induces protection against influenza challenge in mice
-
Berglund, P., Fleeton, M., Smerdou, C. and Liljeström, P. (1999) Immunization with recombinant Semliki Forest virus induces protection against influenza challenge in mice. Vaccine 17: 497–507
-
(1999)
Vaccine
, vol.17
, pp. 497-507
-
-
Berglund, P.1
Fleeton, M.2
Smerdou, C.3
Liljeström, P.4
-
12
-
-
0031838647
-
Enhancing immune responses using suicidal DNA vaccines
-
Berglund, P., Smerdou, C., Fleeton, M., Tubulekas, I. and Liljeström, P. (1998) Enhancing immune responses using suicidal DNA vaccines. Nat Biotechnol 16: 562–565
-
(1998)
Nat Biotechnol
, vol.16
, pp. 562-565
-
-
Berglund, P.1
Smerdou, C.2
Fleeton, M.3
Tubulekas, I.4
Liljeström, P.5
-
13
-
-
85042889314
-
Topical SMIP-7.7, a tolllike receptor 7 agonist, protects against genital herpes simplex virus-2 disease in the guinea pig model of genital herpes
-
12 December, Epub ahead of print
-
Bernstein, D., Cardin, R., Bravo, F., Earwood, J., Clark, J., Li, Y. et al. (2012) Topical SMIP-7.7, a tolllike receptor 7 agonist, protects against genital herpes simplex virus-2 disease in the guinea pig model of genital herpes. Antivir Chem Chemother 12 December (Epub ahead of print).
-
(2012)
Antivir Chem Chemother
-
-
Bernstein, D.1
Cardin, R.2
Bravo, F.3
Earwood, J.4
Clark, J.5
Li, Y.6
-
14
-
-
84869091997
-
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes
-
Biankin, A., Waddell, N., Kassahn, K., Gingras, M., Muthuswamy, L., Johns, A. et al. (2012) Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature 491: 399–405
-
(2012)
Nature
, vol.491
, pp. 399-405
-
-
Biankin, A.1
Waddell, N.2
Kassahn, K.3
Gingras, M.4
Muthuswamy, L.5
Johns, A.6
-
15
-
-
0029839058
-
Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo
-
Boczkowski, D., Nair, S., Snyder, D. and Gilboa, E. (1996) Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo. J Exp Med 184: 465–472
-
(1996)
J Exp Med
, vol.184
, pp. 465-472
-
-
Boczkowski, D.1
Nair, S.2
Snyder, D.3
Gilboa, E.4
-
16
-
-
0141592713
-
Efficient presentation of known HLA class II-restricted MAGE-A3 epitopes by dendritic cells electroporated with messenger RNA encoding an invariant chain with genetic exchange of class II-associated invariant chain peptide
-
Bonehill, A., Heirman, C., Tuyaerts, S., Michiels, A., Zhang, Y., van der Bruggen, P. et al. (2003) Efficient presentation of known HLA class II-restricted MAGE-A3 epitopes by dendritic cells electroporated with messenger RNA encoding an invariant chain with genetic exchange of class II-associated invariant chain peptide. Cancer Res 63: 5587–5594
-
(2003)
Cancer Res
, vol.63
, pp. 5587-5594
-
-
Bonehill, A.1
Heirman, C.2
Tuyaerts, S.3
Michiels, A.4
Zhang, Y.5
Van Der Bruggen, P.6
-
17
-
-
44349173032
-
Enhancing the T-cell stimulatory capacity of human dendritic cells by co-electroporation with CD40L, CD70 and constitutively active TLR4 encoding mRNA
-
Bonehill, A., Tuyaerts, S., Van Nuffel, A., Heirman, C., Bos, T., Fostier, K. et al. (2008) Enhancing the T-cell stimulatory capacity of human dendritic cells by co-electroporation with CD40L, CD70 and constitutively active TLR4 encoding mRNA. Mol Ther 16: 1170–1180
-
(2008)
Mol Ther
, vol.16
, pp. 1170-1180
-
-
Bonehill, A.1
Tuyaerts, S.2
Van Nuffel, A.3
Heirman, C.4
Bos, T.5
Fostier, K.6
-
18
-
-
0842312143
-
Lentivirally transduced dendritic cells as a tool for cancer immunotherapy
-
Breckpot, K., Dullaers, M., Bonehill, A., van Meirvenne, S., Heirman, C., de Greef, C. et al. (2003) Lentivirally transduced dendritic cells as a tool for cancer immunotherapy. J Gene Med 5: 654–667
-
(2003)
J Gene Med
, vol.5
, pp. 654-667
-
-
Breckpot, K.1
Dullaers, M.2
Bonehill, A.3
Van Meirvenne, S.4
Heirman, C.5
De Greef, C.6
-
19
-
-
13644263475
-
Exploiting dendritic cells for cancer immunotherapy: Genetic modification of dendritic cells
-
Breckpot, K., Heirman, C., Neyns, B. and Thielemans, K. (2004) Exploiting dendritic cells for cancer immunotherapy: genetic modification of dendritic cells. J Gene Med 6: 1175–1188
-
(2004)
J Gene Med
, vol.6
, pp. 1175-1188
-
-
Breckpot, K.1
Heirman, C.2
Neyns, B.3
Thielemans, K.4
-
20
-
-
84857725402
-
Exploiting the mutanome for tumor vaccination
-
Castle, J., Kreiter, S., Diekmann, J., Lower, M., van de, Roemer, N., de Graaf, J. et al. (2012) Exploiting the mutanome for tumor vaccination. Cancer Res 72: 1081–1091
-
(2012)
Cancer Res
, vol.72
, pp. 1081-1091
-
-
Castle, J.1
Kreiter, S.2
Diekmann, J.3
Lower, M.4
De Van Roemer, N.5
De Graaf, J.6
-
22
-
-
0028965192
-
Characterization of a messenger RNA polynucleotide vaccine vector
-
Conry, R., LoBuglio, A., Wright, M., Sumerel, L., Pike, M., Johanning, F. et al. (1995) Characterization of a messenger RNA polynucleotide vaccine vector. Cancer Res 55: 1397–1400
-
(1995)
Cancer Res
, vol.55
, pp. 1397-1400
-
-
Conry, R.1
Lobuglio, A.2
Wright, M.3
Sumerel, L.4
Pike, M.5
Johanning, F.6
-
23
-
-
0035051928
-
West Nile virus recombinant DNA vaccine protects mouse and horse from virus challenge and expresses in vitro a noninfectious recombinant antigen that can be used in enzyme-linked immunosorbent assays
-
Davis, B., Chang, G., Cropp, B., Roehrig, J., Martin, D., Mitchell, C. et al. (2001) West Nile virus recombinant DNA vaccine protects mouse and horse from virus challenge and expresses in vitro a noninfectious recombinant antigen that can be used in enzyme-linked immunosorbent assays. J Virol 75: 4040–4047
-
(2001)
J Virol
, vol.75
, pp. 4040-4047
-
-
Davis, B.1
Chang, G.2
Cropp, B.3
Roehrig, J.4
Martin, D.5
Mitchell, C.6
-
24
-
-
84890553500
-
Preclinical comparison of near-infrared-labeled cetuximab and panitumumab for optical imaging of head and neck squamous cell carcinoma
-
29 May, Epub ahead of print
-
Day, K., Sweeny, L., Kulbersh, B., Zinn, K. and Rosenthal, E. (2013) Preclinical comparison of near-infrared-labeled cetuximab and panitumumab for optical imaging of head and neck squamous cell carcinoma. Mol Imaging Biol 29 May (Epub ahead of print).
-
(2013)
Mol Imaging Biol
-
-
Day, K.1
Sweeny, L.2
Kulbersh, B.3
Zinn, K.4
Rosenthal, E.5
-
25
-
-
84862855875
-
Nucleic acid sensing at the interface between innate and adaptive immunity in vaccination
-
Desmet, C. and Ishii, K. (2012) Nucleic acid sensing at the interface between innate and adaptive immunity in vaccination. Nat Rev Immunol 12: 479–491
-
(2012)
Nat Rev Immunol
, vol.12
, pp. 479-491
-
-
Desmet, C.1
Ishii, K.2
-
26
-
-
80355147292
-
Type I interferon is selectively required by dendritic cells for immune rejection of tumors
-
Diamond, M., Kinder, M., Matsushita, H., Mashayekhi, M., Dunn, G., Archambault, J. et al. (2011) Type I interferon is selectively required by dendritic cells for immune rejection of tumors. J Exp Med 208: 1989–2003
-
(2011)
J Exp Med
, vol.208
, pp. 1989-2003
-
-
Diamond, M.1
Kinder, M.2
Matsushita, H.3
Mashayekhi, M.4
Dunn, G.5
Archambault, J.6
-
27
-
-
62549120317
-
Role of TLR3 in the immunogenicity of replicon plasmid-based vaccines
-
Diebold, S., Schulz, O., Alexopoulou, L., Leitner, W., Flavell, R. and Reis e Sousa, C. (2009) Role of TLR3 in the immunogenicity of replicon plasmid-based vaccines. Gene Ther 16: 359–366
-
(2009)
Gene Ther
, vol.16
, pp. 359-366
-
-
Diebold, S.1
Schulz, O.2
Alexopoulou, L.3
Leitner, W.4
Flavell, R.5
Reis E Sousa, C.6
-
28
-
-
79960145796
-
Selective uptake of naked vaccine RNA by dendritic cells is driven by macropinocytosis and abrogated upon DC maturation
-
Diken, M., Kreiter, S., Selmi, A., Britten, C., Huber, C., Tureci, O. et al. (2011) Selective uptake of naked vaccine RNA by dendritic cells is driven by macropinocytosis and abrogated upon DC maturation. Gene Ther 18: 702–708
-
(2011)
Gene Ther
, vol.18
, pp. 702-708
-
-
Diken, M.1
Kreiter, S.2
Selmi, A.3
Britten, C.4
Huber, C.5
Tureci, O.6
-
29
-
-
84878642106
-
Antitumor vaccination with synthetic mRNA: Strategies for in vitro and in vivo preclinical studies
-
Diken, M., Kreiter, S., Selmi, A., Tureci, O. and Sahin, U. (2013) Antitumor vaccination with synthetic mRNA: strategies for in vitro and in vivo preclinical studies. Methods Mol Biol 969: 235–246
-
(2013)
Methods Mol Biol
, vol.969
, pp. 235-246
-
-
Diken, M.1
Kreiter, S.2
Selmi, A.3
Tureci, O.4
Sahin, U.5
-
30
-
-
0029655275
-
Sindbis virus DNA-based expression vectors: Utility for in vitro and in vivo gene transfer
-
Dubensky, T., Jr, Driver, D., Polo, J., Belli, B., Latham, E., Ibanez, C. et al. (1996) Sindbis virus DNA-based expression vectors: utility for in vitro and in vivo gene transfer. J Virol 70: 508–519
-
(1996)
J Virol
, vol.70
, pp. 508-519
-
-
Dubensky, T.1
Driver, D.2
Polo, J.3
Belli, B.4
Latham, E.5
Ibanez, C.6
-
31
-
-
2542430341
-
The three Es of cancer immunoediting
-
Dunn, G., Old, L. and Schreiber, R. (2004) The three Es of cancer immunoediting. Annu Rev Immunol 22: 329–360
-
(2004)
Annu Rev Immunol
, vol.22
, pp. 329-360
-
-
Dunn, G.1
Old, L.2
Schreiber, R.3
-
32
-
-
84884365634
-
Inducing humoral and cellular responses to multiple sporozoite and liver stage malaria antigens using pDNA
-
Ferraro, B., Talbott, K., Balakrishnan, A., Cisper, N., Morrow, M., Hutnick, N. et al. (2013) Inducing humoral and cellular responses to multiple sporozoite and liver stage malaria antigens using pDNA. Infect Immun 81: 3709–3720
-
(2013)
Infect Immun
, vol.81
, pp. 3709-3720
-
-
Ferraro, B.1
Talbott, K.2
Balakrishnan, A.3
Cisper, N.4
Morrow, M.5
Hutnick, N.6
-
33
-
-
85042887646
-
Europe risks ‘vaccine fatigue’
-
8 October
-
Finnegan, G. (2012) Europe risks ‘vaccine fatigue’. Vaccines today 8 October.
-
(2012)
Vaccines Today
-
-
Finnegan, G.1
-
34
-
-
0035341935
-
Self-replicative RNA vaccines elicit protection against influenza A virus, respiratory syncytial virus, and a tickborne encephalitis virus
-
Fleeton, M., Chen, M., Berglund, P., Rhodes, G., Parker, S., Murphy, M. et al. (2001) Self-replicative RNA vaccines elicit protection against influenza A virus, respiratory syncytial virus, and a tickborne encephalitis virus. J Infect Dis 183: 1395–1398
-
(2001)
J Infect Dis
, vol.183
, pp. 1395-1398
-
-
Fleeton, M.1
Chen, M.2
Berglund, P.3
Rhodes, G.4
Parker, S.5
Murphy, M.6
-
35
-
-
0033981840
-
Recombinant Semliki Forest virus particles expressing louping ill virus antigens induce a better protective response than plasmid-based DNA vaccines or an inactivated whole particle vaccine
-
Fleeton, M., Liljeström, P., Sheahan, B. and Atkins, G. (2000) Recombinant Semliki Forest virus particles expressing louping ill virus antigens induce a better protective response than plasmid-based DNA vaccines or an inactivated whole particle vaccine. J Gen Virol 81: 749–758
-
(2000)
J Gen Virol
, vol.81
, pp. 749-758
-
-
Fleeton, M.1
Liljeström, P.2
Sheahan, B.3
Atkins, G.4
-
36
-
-
78650640612
-
Messenger RNA-based vaccines with dual activity induce balanced TLR-7 dependent adaptive immune responses and provide antitumor activity
-
Fotin-Mleczek, M., Duchardt, K., Lorenz, C., Pfeiffer, R., Ojkic-Zrna, S., Probst, J. et al. (2011) Messenger RNA-based vaccines with dual activity induce balanced TLR-7 dependent adaptive immune responses and provide antitumor activity. J Immunother 34: 1–15
-
(2011)
J Immunother
, vol.34
, pp. 1-15
-
-
Fotin-Mleczek, M.1
Duchardt, K.2
Lorenz, C.3
Pfeiffer, R.4
Ojkic-Zrna, S.5
Probst, J.6
-
37
-
-
84862891254
-
Highly potent mRNA based cancer vaccines represent an attractive platform for combination therapies supporting an improved therapeutic effect
-
Fotin-Mleczek, M., Zanzinger, K., Heidenreich, R., Lorenz, C., Thess, A., Duchardt, K. et al. (2012) Highly potent mRNA based cancer vaccines represent an attractive platform for combination therapies supporting an improved therapeutic effect. J Gene Med 14: 428–439
-
(2012)
J Gene Med
, vol.14
, pp. 428-439
-
-
Fotin-Mleczek, M.1
Zanzinger, K.2
Heidenreich, R.3
Lorenz, C.4
Thess, A.5
Duchardt, K.6
-
38
-
-
18444409072
-
Efficacy of an infectious hematopoietic necrosis (IHN) virus DNA vaccine in Chinook Oncorhynchus tshawytscha and sockeye O. nerka salmon
-
Garver, K., LaPatra, S. and Kurath, G. (2005) Efficacy of an infectious hematopoietic necrosis (IHN) virus DNA vaccine in Chinook Oncorhynchus tshawytscha and sockeye O. nerka salmon. Dis Aquat Organ 64: 13–22
-
(2005)
Dis Aquat Organ
, vol.64
, pp. 13-22
-
-
Garver, K.1
Lapatra, S.2
Kurath, G.3
-
39
-
-
84882259948
-
RNA: The new revolution in nucleic acid vaccines
-
Geall, A., Mandl, C. and Ulmer, J. (2013) RNA: The new revolution in nucleic acid vaccines. Semin Immunol 25: 152–159
-
(2013)
Semin Immunol
, vol.25
, pp. 152-159
-
-
Geall, A.1
Mandl, C.2
Ulmer, J.3
-
40
-
-
84865994357
-
Nonviral delivery of selfamplifying RNA vaccines
-
Geall, A., Verma, A., Otten, G., Shaw, C., Hekele, A., Banerjee, K. et al. (2012) Nonviral delivery of selfamplifying RNA vaccines. Proc Natl Acad Sci U S A 109: 14604–14609
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 14604-14609
-
-
Geall, A.1
Verma, A.2
Otten, G.3
Shaw, C.4
Hekele, A.5
Banerjee, K.6
-
41
-
-
34248204110
-
DC-based cancer vaccines
-
Gilboa, E. (2007) DC-based cancer vaccines. J Clin Invest 117: 1195–1203
-
(2007)
J Clin Invest
, vol.117
, pp. 1195-1203
-
-
Gilboa, E.1
-
42
-
-
84859393296
-
MRNA leapfrogs DNA to show promise for therapeutic gene transfer
-
Gilboa, E. (2012) mRNA leapfrogs DNA to show promise for therapeutic gene transfer. Mol Ther 20: 694–695
-
(2012)
Mol Ther
, vol.20
, pp. 694-695
-
-
Gilboa, E.1
-
43
-
-
2942559009
-
Cancer immunotherapy with mRNA-transfected dendritic cells
-
Gilboa, E. and Vieweg, J. (2004) Cancer immunotherapy with mRNA-transfected dendritic cells. Immunol Rev 199: 251–263
-
(2004)
Immunol Rev
, vol.199
, pp. 251-263
-
-
Gilboa, E.1
Vieweg, J.2
-
44
-
-
40049101678
-
IgE in allergy and asthma today
-
Gould, H. and Sutton, B. (2008) IgE in allergy and asthma today. Nat Rev Immunol 8: 205–217
-
(2008)
Nat Rev Immunol
, vol.8
, pp. 205-217
-
-
Gould, H.1
Sutton, B.2
-
45
-
-
82755181916
-
Safety and efficacy of a xenogeneic DNA vaccine encoding for human tyrosinase as adjunctive treatment for oral malignant melanoma in dogs following surgical excision of the primary tumor
-
Grosenbaugh, D., Leard, A., Bergman, P., Klein, M., Meleo, K., Susaneck, S. et al. (2011) Safety and efficacy of a xenogeneic DNA vaccine encoding for human tyrosinase as adjunctive treatment for oral malignant melanoma in dogs following surgical excision of the primary tumor. Am J Vet Res 72: 1631–1638
-
(2011)
Am J Vet Res
, vol.72
, pp. 1631-1638
-
-
Grosenbaugh, D.1
Leard, A.2
Bergman, P.3
Klein, M.4
Meleo, K.5
Susaneck, S.6
-
46
-
-
79959196581
-
Immunotherapy for prostate cancer: Recent advances, lessons learned, and areas for further research
-
Gulley, J. and Drake, C. (2011) Immunotherapy for prostate cancer: recent advances, lessons learned, and areas for further research. Clin Cancer Res 17: 3884–3891
-
(2011)
Clin Cancer Res
, vol.17
, pp. 3884-3891
-
-
Gulley, J.1
Drake, C.2
-
47
-
-
78650583401
-
Role of antigen persistence and dose for CD4+ T-cell exhaustion and recovery
-
Han, S., Asoyan, A., Rabenstein, H., Nakano, N. and Obst, R. (2010) Role of antigen persistence and dose for CD4+ T-cell exhaustion and recovery. Proc Natl Acad Sci U S A 107: 20453–20458
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 20453-20458
-
-
Han, S.1
Asoyan, A.2
Rabenstein, H.3
Nakano, N.4
Obst, R.5
-
48
-
-
71449109765
-
Direct cell reprogramming is a stochastic process amenable to acceleration
-
Hanna, J., Saha, K., Pando, B., van Zon, J., Lengner, C., Creyghton, M. et al. (2009) Direct cell reprogramming is a stochastic process amenable to acceleration. Nature 462: 595–601
-
(2009)
Nature
, vol.462
, pp. 595-601
-
-
Hanna, J.1
Saha, K.2
Pando, B.3
Van Zon, J.4
Lengner, C.5
Creyghton, M.6
-
49
-
-
0031882102
-
DNA immunization against herpes simplex virus: Enhanced efficacy using a Sindbis virus-based vector
-
Hariharan, M., Driver, D., Townsend, K., Brumm, D., Polo, J., Belli, B. et al. (1998) DNA immunization against herpes simplex virus: enhanced efficacy using a Sindbis virus-based vector. J Virol 72: 950–958
-
(1998)
J Virol
, vol.72
, pp. 950-958
-
-
Hariharan, M.1
Driver, D.2
Townsend, K.3
Brumm, D.4
Polo, J.5
Belli, B.6
-
50
-
-
34248653728
-
Analysis of plasmacytoid and myeloid dendritic cells in nasal epithelium
-
Hartmann, E., Graefe, H., Hopert, A., Pries, R., Rothenfusser, S., Poeck, H. et al. (2006) Analysis of plasmacytoid and myeloid dendritic cells in nasal epithelium. Clin Vaccine Immunol 13: 1278–1286
-
(2006)
Clin Vaccine Immunol
, vol.13
, pp. 1278-1286
-
-
Hartmann, E.1
Graefe, H.2
Hopert, A.3
Pries, R.4
Rothenfusser, S.5
Poeck, H.6
-
51
-
-
0141953994
-
Identification and functional analysis of tumorinfiltrating plasmacytoid dendritic cells in head and neck cancer
-
Hartmann, E., Wollenberg, B., Rothenfusser, S., Wagner, M., Wellisch, D., Mack, B. et al. (2003) Identification and functional analysis of tumorinfiltrating plasmacytoid dendritic cells in head and neck cancer. Cancer Res 63: 6478–6487
-
(2003)
Cancer Res
, vol.63
, pp. 6478-6487
-
-
Hartmann, E.1
Wollenberg, B.2
Rothenfusser, S.3
Wagner, M.4
Wellisch, D.5
Mack, B.6
-
52
-
-
84883230210
-
Rapidly produced SAMH vaccine against H7N9 influenza is immunogenic in mice
-
Hekele, A., Bertholet, S., Archer, J., Gibson, D., Palladino, G., Brito, L. et al. (2013) Rapidly produced SAMH vaccine against H7N9 influenza is immunogenic in mice. Emerging Microbes and Infections 2: e52
-
(2013)
Emerging Microbes and Infections
, vol.2
-
-
Hekele, A.1
Bertholet, S.2
Archer, J.3
Gibson, D.4
Palladino, G.5
Brito, L.6
-
53
-
-
39449094869
-
T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation
-
Henrickson, S., Mempel, T., Mazo, I., Liu, B., Artyomov, M., Zheng, H. et al. (2008) T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation. Nat Immunol 9: 282–291
-
(2008)
Nat Immunol
, vol.9
, pp. 282-291
-
-
Henrickson, S.1
Mempel, T.2
Mazo, I.3
Liu, B.4
Artyomov, M.5
Zheng, H.6
-
54
-
-
0033989908
-
In vivo application of RNA leads to induction of specific cytotoxic T lymphocytes and antibodies
-
Hoerr, I., Obst, R., Rammensee, H. and Jung, G. (2000) In vivo application of RNA leads to induction of specific cytotoxic T lymphocytes and antibodies. Eur J Immunol 30: 1–7
-
(2000)
Eur J Immunol
, vol.30
, pp. 1-7
-
-
Hoerr, I.1
Obst, R.2
Rammensee, H.3
Jung, G.4
-
55
-
-
33845497677
-
Modification of antigen-encoding RNA increases stability, translational efficacy, and T-cell stimulatory capacity of dendritic cells
-
Holtkamp, S., Kreiter, S., Selmi, A., Simon, P., Koslowski, M., Huber, C. et al. (2006) Modification of antigen-encoding RNA increases stability, translational efficacy, and T-cell stimulatory capacity of dendritic cells. Blood 108: 4009–4017
-
(2006)
Blood
, vol.108
, pp. 4009-4017
-
-
Holtkamp, S.1
Kreiter, S.2
Selmi, A.3
Simon, P.4
Koslowski, M.5
Huber, C.6
-
56
-
-
79955006476
-
A point mutation in the amino terminus of TLR7 abolishes signaling without affecting ligand binding
-
Iavarone, C., Ramsauer, K., Kubarenko, A., Debasitis, J., Leykin, I., Weber, A. et al. (2011) A point mutation in the amino terminus of TLR7 abolishes signaling without affecting ligand binding. J Immunol 186: 4213–4222
-
(2011)
J Immunol
, vol.186
, pp. 4213-4222
-
-
Iavarone, C.1
Ramsauer, K.2
Kubarenko, A.3
Debasitis, J.4
Leykin, I.5
Weber, A.6
-
57
-
-
0029045376
-
A Sindbis virus mRNA polynucleotide vector achieves prolonged and high level heterologous gene expression in vivo
-
Johanning, F., Conry, R., LoBuglio, A., Wright, M., Sumerel, L., Pike, M. et al. (1995) A Sindbis virus mRNA polynucleotide vector achieves prolonged and high level heterologous gene expression in vivo. Nucleic Acids Res 23: 1495–1501
-
(1995)
Nucleic Acids Res
, vol.23
, pp. 1495-1501
-
-
Johanning, F.1
Conry, R.2
Lobuglio, A.3
Wright, M.4
Sumerel, L.5
Pike, M.6
-
58
-
-
84855383397
-
Intradermal electroporation of naked replicon RNA elicits strong immune responses
-
Johansson, D., Ljungberg, K., Kakoulidou, M. and Liljeström, P. (2012) Intradermal electroporation of naked replicon RNA elicits strong immune responses. PLoS One 7: e29732
-
(2012)
Plos One
, vol.7
-
-
Johansson, D.1
Ljungberg, K.2
Kakoulidou, M.3
Liljeström, P.4
-
59
-
-
0034955802
-
Molecular pathogenesis of influenza A virus infection and virus-induced regulation of cytokine gene expression
-
Julkunen, I., Sareneva, T., Pirhonen, J., Ronni, T., Melen, K. and Matikainen, S. (2001) Molecular pathogenesis of influenza A virus infection and virus-induced regulation of cytokine gene expression. Cytokine Growth Factor Rev 12: 171–180
-
(2001)
Cytokine Growth Factor Rev
, vol.12
, pp. 171-180
-
-
Julkunen, I.1
Sareneva, T.2
Pirhonen, J.3
Ronni, T.4
Melen, K.5
Matikainen, S.6
-
60
-
-
84885113945
-
A novel, disruptive vaccination technology: Self-adjuvanted RNActive® vaccines
-
Kallen, K., Heidenreich, R., Schnee, M., Petsch, B., Schlake, T., Thess, A. et al. (2013) A novel, disruptive vaccination technology: self-adjuvanted RNActive® vaccines. Hum Vaccin Immunother 9: 2263–2276
-
(2013)
Hum Vaccin Immunother
, vol.9
, pp. 2263-2276
-
-
Kallen, K.1
Heidenreich, R.2
Schnee, M.3
Petsch, B.4
Schlake, T.5
Thess, A.6
-
61
-
-
23844464444
-
Suppression of RNA recognition by Toll-like receptors: The impact of nucleoside modification and the evolutionary origin of RNA
-
Kariko, K., Buckstein, M., Ni, H. and Weissman, D. (2005) Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA. Immunity 23: 165–175
-
(2005)
Immunity
, vol.23
, pp. 165-175
-
-
Kariko, K.1
Buckstein, M.2
Ni, H.3
Weissman, D.4
-
62
-
-
84860539841
-
Increased erythropoiesis in mice injected with submicrogram quantities of pseudouridinecontaining mRNA encoding erythropoietin
-
Kariko, K., Muramatsu, H., Keller, J. and Weissman, D. (2012) Increased erythropoiesis in mice injected with submicrogram quantities of pseudouridinecontaining mRNA encoding erythropoietin. Mol Ther 20: 948–953
-
(2012)
Mol Ther
, vol.20
, pp. 948-953
-
-
Kariko, K.1
Muramatsu, H.2
Keller, J.3
Weissman, D.4
-
63
-
-
54949112814
-
Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability
-
Kariko, K., Muramatsu, H., Welsh, F., Ludwig, J., Kato, H., Akira, S. et al. (2008) Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability. Mol Ther 16: 1833–1840
-
(2008)
Mol Ther
, vol.16
, pp. 1833-1840
-
-
Kariko, K.1
Muramatsu, H.2
Welsh, F.3
Ludwig, J.4
Kato, H.5
Akira, S.6
-
64
-
-
34548431318
-
Naturally occurring nucleoside modifications suppress the immunostimulatory activity of RNA: Implication for therapeutic RNA development
-
Kariko, K. and Weissman, D. (2007) Naturally occurring nucleoside modifications suppress the immunostimulatory activity of RNA: implication for therapeutic RNA development. Curr Opin Drug Discov Devel 10: 523–532
-
(2007)
Curr Opin Drug Discov Devel
, vol.10
, pp. 523-532
-
-
Kariko, K.1
Weissman, D.2
-
65
-
-
85007181047
-
-
Patent WO2008077592
-
Ketterer, T., von der Mülbe, F., Reidel, L. and Mutzke, T. (2008) Method for purifying RNA on a preparative scale by means of HPLC. Patent WO2008077592
-
(2008)
Method for Purifying RNA on a Preparative Scale by means of HPLC
-
-
Ketterer, T.1
Von Der Mülbe, F.2
Reidel, L.3
Mutzke, T.4
-
66
-
-
84859007690
-
A novel therapeutic cytomegalovirus DNA vaccine in allogeneic haemopoietic stem-cell transplantation: A randomised, double-blind, placebo-controlled, phase 2 trial
-
Kharfan-Dabaja, M., Boeckh, M., Wilck, M., Langston, A., Chu, A., Wloch, M. et al. (2012) A novel therapeutic cytomegalovirus DNA vaccine in allogeneic haemopoietic stem-cell transplantation: a randomised, double-blind, placebo-controlled, phase 2 trial. Lancet Infect Dis 12: 290–299
-
(2012)
Lancet Infect Dis
, vol.12
, pp. 290-299
-
-
Kharfan-Dabaja, M.1
Boeckh, M.2
Wilck, M.3
Langston, A.4
Chu, A.5
Wloch, M.6
-
67
-
-
84876067164
-
TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal
-
Killela, P., Reitman, Z., Jiao, Y., Bettegowda, C., Agrawal, N., Diaz, L., Jr et al. (2013) TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal. Proc Natl Acad Sci U S A 110: 6021–6026
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 6021-6026
-
-
Killela, P.1
Reitman, Z.2
Jiao, Y.3
Bettegowda, C.4
Agrawal, N.5
Diaz, L.6
-
68
-
-
0037218553
-
Enhanced immunogenicity to Mycobacterium tuberculosis by vaccination with an alphavirus plasmid replicon expressing antigen 85A
-
Kirman, J., Turon, T., Su, H., Li, A., Kraus, C., Polo, J. et al. (2003) Enhanced immunogenicity to Mycobacterium tuberculosis by vaccination with an alphavirus plasmid replicon expressing antigen 85A. Infect Immun 71: 575–579
-
(2003)
Infect Immun
, vol.71
, pp. 575-579
-
-
Kirman, J.1
Turon, T.2
Su, H.3
Li, A.4
Kraus, C.5
Polo, J.6
-
69
-
-
79751497093
-
Expression of therapeutic proteins after delivery of chemically modified mRNA in mice
-
Kormann, M., Hasenpusch, G., Aneja, M., Nica, G., Flemmer, A., Herber-Jonat, S. et al. (2011) Expression of therapeutic proteins after delivery of chemically modified mRNA in mice. Nat Biotechnol 29: 154–157
-
(2011)
Nat Biotechnol
, vol.29
, pp. 154-157
-
-
Kormann, M.1
Hasenpusch, G.2
Aneja, M.3
Nica, G.4
Flemmer, A.5
Herber-Jonat, S.6
-
70
-
-
1642268316
-
Cutting edge: Innate immune system discriminates between RNA containing bacterial versus eukaryotic structural features that prime for high-level IL-12 secretion by dendritic cells
-
Koski, G., Kariko, K., Xu, S., Weissman, D., Cohen, P. and Czerniecki, B. (2004) Cutting edge: innate immune system discriminates between RNA containing bacterial versus eukaryotic structural features that prime for high-level IL-12 secretion by dendritic cells. J Immunol 172: 3989–3993
-
(2004)
J Immunol
, vol.172
, pp. 3989-3993
-
-
Koski, G.1
Kariko, K.2
Xu, S.3
Weissman, D.4
Cohen, P.5
Czerniecki, B.6
-
71
-
-
84883251918
-
Targeting the tumor mutanome for personalized vaccination therapy
-
Kreiter, S., Castle, J., Tureci, O. and Sahin, U. (2012) Targeting the tumor mutanome for personalized vaccination therapy. Oncoimmunology 1: 768–769
-
(2012)
Oncoimmunology
, vol.1
, pp. 768-769
-
-
Kreiter, S.1
Castle, J.2
Tureci, O.3
Sahin, U.4
-
72
-
-
79957732443
-
Tumor vaccination using messenger RNA: Prospects of a future therapy
-
Kreiter, S., Diken, M., Selmi, A., Tureci, O. and Sahin, U. (2011) Tumor vaccination using messenger RNA: prospects of a future therapy. Curr Opin Immunol 23: 399–406
-
(2011)
Curr Opin Immunol
, vol.23
, pp. 399-406
-
-
Kreiter, S.1
Diken, M.2
Selmi, A.3
Tureci, O.4
Sahin, U.5
-
73
-
-
78549283854
-
Intranodal vaccination with naked antigen-encoding RNA elicits potent prophylactic and therapeutic antitumoral immunity
-
Kreiter, S., Selmi, A., Diken, M., Koslowski, M., Britten, C., Huber, C. et al. (2010) Intranodal vaccination with naked antigen-encoding RNA elicits potent prophylactic and therapeutic antitumoral immunity. Cancer Res 70: 9031–9040
-
(2010)
Cancer Res
, vol.70
, pp. 9031-9040
-
-
Kreiter, S.1
Selmi, A.2
Diken, M.3
Koslowski, M.4
Britten, C.5
Huber, C.6
-
74
-
-
40449083962
-
Increased antigen presentation efficiency by coupling antigens to MHC class I trafficking signals
-
Kreiter, S., Selmi, A., Diken, M., Sebastian, M., Osterloh, P., Schild, H. et al. (2008) Increased antigen presentation efficiency by coupling antigens to MHC class I trafficking signals. J Immunol 180: 309–318
-
(2008)
J Immunol
, vol.180
, pp. 309-318
-
-
Kreiter, S.1
Selmi, A.2
Diken, M.3
Sebastian, M.4
Osterloh, P.5
Schild, H.6
-
75
-
-
84870924928
-
Final analysis of a phase I/IIa study with CV9103, an intradermally administered prostate cancer immunotherapy based on self-adjuvanted mRNA
-
Kübler, H., Maurer, T., Stenzl, A., Feyerabend, S., Steiner, U., Schostak, M. et al. (2011) Final analysis of a phase I/IIa study with CV9103, an intradermally administered prostate cancer immunotherapy based on self-adjuvanted mRNA. J Clin Oncol 29(Suppl.): abstract 4535
-
(2011)
J Clin Oncol
, vol.29
-
-
Kübler, H.1
Maurer, T.2
Stenzl, A.3
Feyerabend, S.4
Steiner, U.5
Schostak, M.6
-
76
-
-
77955658245
-
Phosphorothioate cap analogs increase stability and translational efficiency of RNA vaccines in immature dendritic cells and induce superior immune responses in vivo
-
Kuhn, A., Diken, M., Kreiter, S., Selmi, A., Kowalska, J., Jemielity, J. et al. (2010) Phosphorothioate cap analogs increase stability and translational efficiency of RNA vaccines in immature dendritic cells and induce superior immune responses in vivo. Gene Ther 17: 961–971
-
(2010)
Gene Ther
, vol.17
, pp. 961-971
-
-
Kuhn, A.1
Diken, M.2
Kreiter, S.3
Selmi, A.4
Kowalska, J.5
Jemielity, J.6
-
77
-
-
29044437033
-
Protective immunity and lack of histopathological damage two years after DNA vaccination against infectious hematopoietic necrosis virus in trout
-
Kurath, G., Garver, K., Corbeil, S., Elliott, D., Anderson, E. and LaPatra, S. (2006) Protective immunity and lack of histopathological damage two years after DNA vaccination against infectious hematopoietic necrosis virus in trout. Vaccine 24: 345–354
-
(2006)
Vaccine
, vol.24
, pp. 345-354
-
-
Kurath, G.1
Garver, K.2
Corbeil, S.3
Elliott, D.4
Erson, E.5
Lapatra, S.6
-
78
-
-
84868007347
-
Activation of innate immunity is required for efficient nuclear reprogramming
-
Lee, J., Sayed, N., Hunter, A., Au, K., Wong, W., Mocarski, E. et al. (2012) Activation of innate immunity is required for efficient nuclear reprogramming. Cell 151: 547–558
-
(2012)
Cell
, vol.151
, pp. 547-558
-
-
Lee, J.1
Sayed, N.2
Hunter, A.3
Au, K.4
Wong, W.5
Mocarski, E.6
-
79
-
-
0037236237
-
Alphavirusbased DNA vaccine breaks immunological tolerance by activating innate antiviral pathways
-
Leitner, W., Hwang, L., deVeer, M., Zhou, A., Silverman, R., Williams, B. et al. (2003) Alphavirusbased DNA vaccine breaks immunological tolerance by activating innate antiviral pathways. Nat Med 9: 33–39
-
(2003)
Nat Med
, vol.9
, pp. 33-39
-
-
Leitner, W.1
Hwang, L.2
Deveer, M.3
Zhou, A.4
Silverman, R.5
Williams, B.6
-
80
-
-
0033955167
-
Enhancement of tumor-specific immune response with plasmid DNA replicon vectors
-
Leitner, W., Ying, H., Driver, D., Dubensky, T. and Restifo, N. (2000) Enhancement of tumor-specific immune response with plasmid DNA replicon vectors. Cancer Res 60: 51–55
-
(2000)
Cancer Res
, vol.60
, pp. 51-55
-
-
Leitner, W.1
Ying, H.2
Driver, D.3
Dubensky, T.4
Restifo, N.5
-
81
-
-
84878487919
-
How do we optimally use cetuximab in first-line treatment for metastatic colorectal cancer?
-
Lindsay, C., Roxburgh, P. and Graham, J. (2013) How do we optimally use cetuximab in first-line treatment for metastatic colorectal cancer? Future Oncol 9: 825–829
-
(2013)
Future Oncol
, vol.9
, pp. 825-829
-
-
Lindsay, C.1
Roxburgh, P.2
Graham, J.3
-
82
-
-
84869211465
-
Hemophilia and prophylaxis
-
Ljung, R. (2013) Hemophilia and prophylaxis. Pediatr Blood Cancer 60(Suppl. 1): S23–S26
-
(2013)
Pediatr Blood Cancer
, vol.60
-
-
Ljung, R.1
-
83
-
-
79960107932
-
Protein expression from exogenous mRNA: Uptake by receptor-mediated endocytosis and trafficking via the lysosomal pathway
-
Lorenz, C., Fotin-Mleczek, M., Roth, G., Becker, C., Dam, T., Verdurmen, W. et al. (2011) Protein expression from exogenous mRNA: uptake by receptor-mediated endocytosis and trafficking via the lysosomal pathway. RNA Biol 8: 627–636
-
(2011)
RNA Biol
, vol.8
, pp. 627-636
-
-
Lorenz, C.1
Fotin-Mleczek, M.2
Roth, G.3
Becker, C.4
Dam, T.5
Verdurmen, W.6
-
84
-
-
84861178107
-
Clinical evaluation of TRICOM vector therapeutic cancer vaccines
-
Madan, R., Bilusic, M., Heery, C., Schlom, J. and Gulley, J. (2012) Clinical evaluation of TRICOM vector therapeutic cancer vaccines. Semin Oncol 39: 296–304
-
(2012)
Semin Oncol
, vol.39
, pp. 296-304
-
-
Madan, R.1
Bilusic, M.2
Heery, C.3
Schlom, J.4
Gulley, J.5
-
85
-
-
84875160871
-
Reprogramming human fibroblasts to pluripotency using modified mRNA
-
Mandal, P. and Rossi, D. (2013) Reprogramming human fibroblasts to pluripotency using modified mRNA. Nat Protoc 8: 568–582
-
(2013)
Nat Protoc
, vol.8
, pp. 568-582
-
-
Mandal, P.1
Rossi, D.2
-
86
-
-
79961167250
-
DNA released from dying host cells mediates aluminum adjuvant activity
-
Marichal, T., Ohata, K., Bedoret, D., Mesnil, C., Sabatel, C., Kobiyama, K. et al. (2011) DNA released from dying host cells mediates aluminum adjuvant activity. Nat Med 17: 996–1002
-
(2011)
Nat Med
, vol.17
, pp. 996-1002
-
-
Marichal, T.1
Ohata, K.2
Bedoret, D.3
Mesnil, C.4
Sabatel, C.5
Kobiyama, K.6
-
87
-
-
0027170483
-
Induction of virus-specific cytotoxic T lymphocytes in vivo by liposome-entrapped mRNA
-
Martinon, F., Krishnan, S., Lenzen, G., Magne, R., Gomard, E., Guillet, J. et al. (1993) Induction of virus-specific cytotoxic T lymphocytes in vivo by liposome-entrapped mRNA. Eur J Immunol 23: 1719–1722
-
(1993)
Eur J Immunol
, vol.23
, pp. 1719-1722
-
-
Martinon, F.1
Krishnan, S.2
Lenzen, G.3
Magne, R.4
Gomard, E.5
Guillet, J.6
-
88
-
-
77953534296
-
New adjuvants for human vaccines
-
Mbow, M., De Gregorio, E., Valiante, N. and Rappuoli, R. (2010) New adjuvants for human vaccines. Curr Opin Immunol 22: 411–416
-
(2010)
Curr Opin Immunol
, vol.22
, pp. 411-416
-
-
Mbow, M.1
De Gregorio, E.2
Valiante, N.3
Rappuoli, R.4
-
89
-
-
84870328782
-
The efficacy of biologic agents in patients with rheumatoid arthritis and an inadequate response to tumour necrosis factor inhibitors: A systematic review
-
Moots, R. and Naisbett-Groet, B. (2012) The efficacy of biologic agents in patients with rheumatoid arthritis and an inadequate response to tumour necrosis factor inhibitors: a systematic review. Rheumatology (Oxford) 51: 2252–2261
-
(2012)
Rheumatology (Oxford)
, vol.51
, pp. 2252-2261
-
-
Moots, R.1
Naisbett-Groet, B.2
-
90
-
-
77956372182
-
An alphavirus vector overcomes the presence of neutralizing antibodies and elevated numbers of Tregs to induce immune responses in humans with advanced cancer
-
Morse, M., Hobeika, A., Osada, T., Berglund, P., Hubby, B., Negri, S. et al. (2010) An alphavirus vector overcomes the presence of neutralizing antibodies and elevated numbers of Tregs to induce immune responses in humans with advanced cancer. J Clin Invest 120: 3234–3241
-
(2010)
J Clin Invest
, vol.120
, pp. 3234-3241
-
-
Morse, M.1
Hobeika, A.2
Osada, T.3
Berglund, P.4
Hubby, B.5
Negri, S.6
-
91
-
-
33744473294
-
Intrasplenic steady-state dendritic cell precursors that are distinct from monocytes
-
Naik, S., Metcalf, D., van Nieuwenhuijze, A., Wicks, I., Wu, L., O’Keeffe, M. et al. (2006) Intrasplenic steady-state dendritic cell precursors that are distinct from monocytes. Nat Immunol 7: 663–671
-
(2006)
Nat Immunol
, vol.7
, pp. 663-671
-
-
Naik, S.1
Metcalf, D.2
Van Nieuwenhuijze, A.3
Wicks, I.4
Wu, L.5
O’Keeffe, M.6
-
92
-
-
84939472843
-
Phase IB study on combined intradermal (ID) and intravenous (IV) administration of autologous mRNA electroporated dendritic cells (DC) as a singleagent cellular immunotherapy or combined with ipilimumab
-
Neyns, B., Wilgenhof, S., Van Nuffel, A., Benteyn, D. and Corthals, J., Heirman, C. et al. (2012) Phase IB study on combined intradermal (ID) and intravenous (IV) administration of autologous mRNA electroporated dendritic cells (DC) as a singleagent cellular immunotherapy or combined with ipilimumab. J Clin Oncol 30(Suppl.): abstract 2507
-
(2012)
J Clin Oncol
, vol.30
-
-
Neyns, B.1
Wilgenhof, S.2
Van Nuffel, A.3
Benteyn, D.4
Corthals, J.5
Heirman, C.6
-
93
-
-
4944223122
-
Manipulating dendritic cell biology for the active immunotherapy of cancer
-
O’Neill, D., Adams, S. and Bhardwaj, N. (2004) Manipulating dendritic cell biology for the active immunotherapy of cancer. Blood 104: 2235–2246
-
(2004)
Blood
, vol.104
, pp. 2235-2246
-
-
O’Neill, D.1
Adams, S.2
Bhardwaj, N.3
-
94
-
-
21844450539
-
Antigenengaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells
-
Okada, T., Miller, M., Parker, I., Krummel, M., Neighbors, M., Hartley, S. et al. (2005) Antigenengaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells. PLoS Biol 3: e150
-
(2005)
Plos Biol
, vol.3
-
-
Okada, T.1
Miller, M.2
Parker, I.3
Krummel, M.4
Neighbors, M.5
Hartley, S.6
-
95
-
-
84874310182
-
Structure and dynamic regulation of Abl kinases
-
Panjarian, S., Iacob, R., Chen, S., Engen, J. and Smithgall, T. (2013) Structure and dynamic regulation of Abl kinases. J Biol Chem 288: 5443–5450
-
(2013)
J Biol Chem
, vol.288
, pp. 5443-5450
-
-
Panjarian, S.1
Iacob, R.2
Chen, S.3
Engen, J.4
Smithgall, T.5
-
96
-
-
3442896311
-
Messenger RNA-based vaccines
-
Pascolo, S. (2004) Messenger RNA-based vaccines. Expert Opin Biol Ther 4: 1285–1294
-
(2004)
Expert Opin Biol Ther
, vol.4
, pp. 1285-1294
-
-
Pascolo, S.1
-
97
-
-
33750110852
-
Vaccination with messenger RNA
-
Pascolo, S. (2006) Vaccination with messenger RNA. Methods Mol Med 127: 23–40
-
(2006)
Methods Mol Med
, vol.127
, pp. 23-40
-
-
Pascolo, S.1
-
98
-
-
84870869040
-
Protective efficacy of in vitro synthesized, specific mRNA vaccines against influenza A virus infection
-
Petsch, B., Schnee, M., Vogel, A., Lange, E., Hoffmann, B., Voss, D. et al. (2012) Protective efficacy of in vitro synthesized, specific mRNA vaccines against influenza A virus infection. Nat Biotechnol 30: 1210–1216
-
(2012)
Nat Biotechnol
, vol.30
, pp. 1210-1216
-
-
Petsch, B.1
Schnee, M.2
Vogel, A.3
Lange, E.4
Hoffmann, B.5
Voss, D.6
-
99
-
-
33750984771
-
RIG-Imediated antiviral responses to single-stranded RNA bearing 5’-phosphates
-
Pichlmair, A., Schulz, O., Tan, C., Naslund, T., Liljeström, P., Weber, F. et al. (2006) RIG-Imediated antiviral responses to single-stranded RNA bearing 5’-phosphates. Science 314: 997–1001
-
(2006)
Science
, vol.314
, pp. 997-1001
-
-
Pichlmair, A.1
Schulz, O.2
Tan, C.3
Naslund, T.4
Liljeström, P.5
Weber, F.6
-
100
-
-
84871926389
-
Type I IFN counteracts the induction of antigen-specific immune responses by lipid-based delivery of mRNA vaccines
-
Pollard, C., Rejman, J., De Haes, W., Verrier, B., Van Gulck, E., Naessens, T. et al. (2013) Type I IFN counteracts the induction of antigen-specific immune responses by lipid-based delivery of mRNA vaccines. Mol Ther 21: 251–259
-
(2013)
Mol Ther
, vol.21
, pp. 251-259
-
-
Pollard, C.1
Rejman, J.2
De Haes, W.3
Verrier, B.4
Van Gulck, E.5
Naessens, T.6
-
101
-
-
84875880394
-
Considerations for early switch to nilotinib or dasatinib in patients with chronic myeloid leukemia with inadequate response to first-line imatinib
-
Quintas-Cardama, A. and Jabbour, E. (2013) Considerations for early switch to nilotinib or dasatinib in patients with chronic myeloid leukemia with inadequate response to first-line imatinib. Leuk Res 37: 487–495
-
(2013)
Leuk Res
, vol.37
, pp. 487-495
-
-
Quintas-Cardama, A.1
Jabbour, E.2
-
102
-
-
75749140581
-
RIG-I detects viral genomic RNA during negative-strand RNA virus infection
-
Rehwinkel, J., Tan, C., Goubau, D., Schulz, O., Pichlmair, A., Bier, K. et al. (2010) RIG-I detects viral genomic RNA during negative-strand RNA virus infection. Cell 140: 397–408
-
(2010)
Cell
, vol.140
, pp. 397-408
-
-
Rehwinkel, J.1
Tan, C.2
Goubau, D.3
Schulz, O.4
Pichlmair, A.5
Bier, K.6
-
103
-
-
79955630363
-
Intradermal vaccinations with RNA coding for TAA generate CD8+ and CD4+ immune responses and induce clinical benefit in vaccinated patients
-
Rittig, S., Haentschel, M., Weimer, K., Heine, A., Muller, M., Brugger, W. et al. (2011) Intradermal vaccinations with RNA coding for TAA generate CD8+ and CD4+ immune responses and induce clinical benefit in vaccinated patients. Mol Ther 19: 990–999
-
(2011)
Mol Ther
, vol.19
, pp. 990-999
-
-
Rittig, S.1
Haentschel, M.2
Weimer, K.3
Heine, A.4
Muller, M.5
Brugger, W.6
-
104
-
-
84858664440
-
Rituximab for chronic lymphocytic leukemia
-
Robak, T. (2012) Rituximab for chronic lymphocytic leukemia. Expert Opin Biol Ther 12: 503–515
-
(2012)
Expert Opin Biol Ther
, vol.12
, pp. 503-515
-
-
Robak, T.1
-
105
-
-
71749093911
-
Immunize and disappear-safety-optimized mRNA vaccination with a panel of 29 allergens
-
Roesler, E., Weiss, R., Weinberger, E., Fruehwirth, A., Stoecklinger, A., Mostbock, S. et al. (2009) Immunize and disappear-safety-optimized mRNA vaccination with a panel of 29 allergens. J Allergy Clin Immunol 124: 1070–1077 e1071-1011
-
(2009)
J Allergy Clin Immunol
, vol.124
-
-
Roesler, E.1
Weiss, R.2
Weinberger, E.3
Fruehwirth, A.4
Stoecklinger, A.5
Mostbock, S.6
-
106
-
-
79957590694
-
Small molecule toll-like receptor 7 agonists localize to the MHC class II loading compartment of human plasmacytoid dendritic cells
-
Russo, C., Cornella-Taracido, I., Galli-Stampino, L., Jain, R., Harrington, E., Isome, Y. et al. (2011) Small molecule toll-like receptor 7 agonists localize to the MHC class II loading compartment of human plasmacytoid dendritic cells. Blood 117: 5683–5691
-
(2011)
Blood
, vol.117
, pp. 5683-5691
-
-
Russo, C.1
Cornella-Taracido, I.2
Galli-Stampino, L.3
Jain, R.4
Harrington, E.5
Isome, Y.6
-
107
-
-
79957781340
-
Electroporation delivery of DNA vaccines: Prospects for success
-
Sardesai, N. and Weiner, D. (2011) Electroporation delivery of DNA vaccines: prospects for success. Curr Opin Immunol 23: 421–429
-
(2011)
Curr Opin Immunol
, vol.23
, pp. 421-429
-
-
Sardesai, N.1
Weiner, D.2
-
108
-
-
33645325115
-
Dacarbazine (DTIC) versus vaccination with autologous peptide-pulsed dendritic cells (DC) in first-line treatment of patients with metastatic melanoma: A randomized phase III trial of the DC study group of the DeCOG
-
Schadendorf, D., Ugurel, S., Schuler-Thurner, B., Nestle, F., Enk, A., Brocker, E. et al. (2006) Dacarbazine (DTIC) versus vaccination with autologous peptide-pulsed dendritic cells (DC) in first-line treatment of patients with metastatic melanoma: a randomized phase III trial of the DC study group of the DeCOG. Ann Oncol 17: 563–570
-
(2006)
Ann Oncol
, vol.17
, pp. 563-570
-
-
Schadendorf, D.1
Ugurel, S.2
Schuler-Thurner, B.3
Nestle, F.4
Enk, A.5
Brocker, E.6
-
109
-
-
21044440406
-
Toll-like receptordependent activation of several human blood cell types by protamine-condensed mRNA
-
Scheel, B., Teufel, R., Probst, J., Carralot, J., Geginat, J., Radsak, M. et al. (2005) Toll-like receptordependent activation of several human blood cell types by protamine-condensed mRNA. Eur J Immunol 35: 1557–1566
-
(2005)
Eur J Immunol
, vol.35
, pp. 1557-1566
-
-
Scheel, B.1
Teufel, R.2
Probst, J.3
Carralot, J.4
Geginat, J.5
Radsak, M.6
-
110
-
-
33745126286
-
Inhibition of type I allergic responses with nanogram doses of repliconbased DNA vaccines
-
Scheiblhofer, S., Gabler, M., Leitner, W., Bauer, R., Zoegg, T., Ferreira, F. et al. (2006a) Inhibition of type I allergic responses with nanogram doses of repliconbased DNA vaccines. Allergy 61: 828–835
-
(2006)
Allergy
, vol.61
, pp. 828-835
-
-
Scheiblhofer, S.1
Gabler, M.2
Leitner, W.3
Bauer, R.4
Zoegg, T.5
Ferreira, F.6
-
111
-
-
84878095825
-
Laser microporation of the skin: Prospects for painless application of protective and therapeutic vaccines
-
Scheiblhofer, S., Thalhamer, J. and Weiss, R. (2013) Laser microporation of the skin: prospects for painless application of protective and therapeutic vaccines. Expert Opin Drug Deliv 10: 761–773
-
(2013)
Expert Opin Drug Deliv
, vol.10
, pp. 761-773
-
-
Scheiblhofer, S.1
Thalhamer, J.2
Weiss, R.3
-
112
-
-
33750122080
-
Replicase-based DNA vaccines for allergy treatment
-
Scheiblhofer, S., Weiss, R., Gabler, M., Leitner, W. and Thalhamer, J. (2006b) Replicase-based DNA vaccines for allergy treatment. Methods Mol Med 127: 221–235
-
(2006)
Methods Mol Med
, vol.127
, pp. 221-235
-
-
Scheiblhofer, S.1
Weiss, R.2
Gabler, M.3
Leitner, W.4
Thalhamer, J.5
-
113
-
-
84870886906
-
Developing mRNA-vaccine technologies
-
Schlake, T., Thess, A., Fotin-Mleczek, M. and Kallen, K. (2012) Developing mRNA-vaccine technologies. RNA Biol 9: 1319–1330
-
(2012)
RNA Biol
, vol.9
, pp. 1319-1330
-
-
Schlake, T.1
Thess, A.2
Fotin-Mleczek, M.3
Kallen, K.4
-
114
-
-
20044382430
-
Toll-like receptor 3 promotes cross-priming to virus-infected cells
-
Schulz, O., Diebold, S., Chen, M., Naslund, T., Nolte, M., Alexopoulou, L. et al. (2005) Toll-like receptor 3 promotes cross-priming to virus-infected cells. Nature 433: 887–892
-
(2005)
Nature
, vol.433
, pp. 887-892
-
-
Schulz, O.1
Diebold, S.2
Chen, M.3
Naslund, T.4
Nolte, M.5
Alexopoulou, L.6
-
115
-
-
84870955822
-
Messenger RNA vaccination in NSCLC: Findings from a phase I/IIa clinical trial
-
Sebastian, M., von Boehmer, L., Zippelius, A., Mayer, F., Reck, M., Atanackovic, et al. (2011) Messenger RNA vaccination in NSCLC: findings from a phase I/IIa clinical trial. J Clin Oncol 29(Suppl.): abstract 2584
-
(2011)
J Clin Oncol
, vol.29
-
-
Sebastian, M.1
Von Boehmer, L.2
Zippelius, A.3
Mayer, F.4
Reck, Atanackovic, M.5
-
116
-
-
84885096230
-
Messenger RNA vaccination and B-cell responses in NSCLC patients
-
Sebastian, M., von Boehmer, L., Zippelius, A., Mayer, F. and Reck, M., Atanackovic, D. et al. (2012) Messenger RNA vaccination and B-cell responses in NSCLC patients.. J Clin Oncol 30(Suppl.): abstract 2573
-
(2012)
J Clin Oncol
, vol.30
-
-
Sebastian, M.1
Von Boehmer, L.2
Zippelius, A.3
Mayer, F.4
Reck, M.5
Atanackovic, D.6
-
117
-
-
84883245346
-
CCL19, a B-cell chemokine, is related to the decrease of blood memory B-cells and predicts the clinical response to rituximab in rheumatoid arthritis
-
Sellam, J., Rouanet, S., Hendel-Chavez, H., Miceli- Richard, C., Combe, B., Sibilia, J. et al. (2013) CCL19, a B-cell chemokine, is related to the decrease of blood memory B-cells and predicts the clinical response to rituximab in rheumatoid arthritis. Arthritis Rheum 65: 2253–2261
-
(2013)
Arthritis Rheum
, vol.65
, pp. 2253-2261
-
-
Sellam, J.1
Rouanet, S.2
Hendel-Chavez, H.3
Miceli- Richard, C.4
Combe, B.5
Sibilia, J.6
-
118
-
-
34548050436
-
CD8 T cell dysfunction during chronic viral infection
-
Shin, H. and Wherry, E. (2007) CD8 T cell dysfunction during chronic viral infection. Curr Opin Immunol 19: 408–415
-
(2007)
Curr Opin Immunol
, vol.19
, pp. 408-415
-
-
Shin, H.1
Wherry, E.2
-
119
-
-
84872618287
-
A phase I dose escalation trial of vaccine replicon particles (VRP) expressing prostatespecific membrane antigen (PSMA) in subjects with prostate cancer
-
Slovin, S., Kehoe, M., Durso, R., Fernandez, C., Olson, W., Gao, J. et al. (2013) A phase I dose escalation trial of vaccine replicon particles (VRP) expressing prostatespecific membrane antigen (PSMA) in subjects with prostate cancer. Vaccine 31: 943–949
-
(2013)
Vaccine
, vol.31
, pp. 943-949
-
-
Slovin, S.1
Kehoe, M.2
Durso, R.3
Fernandez, C.4
Olson, W.5
Gao, J.6
-
120
-
-
84876232194
-
Cetuximab: Its unique place in head and neck cancer treatment
-
Specenier, P. and Vermorken, J. (2013) Cetuximab: its unique place in head and neck cancer treatment. Biologics 7: 77–90
-
(2013)
Biologics
, vol.7
, pp. 77-90
-
-
Specenier, P.1
Vermorken, J.2
-
121
-
-
84857304221
-
NOD/scid IL-2Rg(Null) mice: A preclinical model system to evaluate human dendritic cell-based vaccine strategies in vivo
-
Spranger, S., Frankenberger, B. and Schendel, D. (2012) NOD/scid IL-2Rg(null) mice: a preclinical model system to evaluate human dendritic cell-based vaccine strategies in vivo. J Transl Med 10: 30
-
(2012)
J Transl Med
, vol.10
-
-
Spranger, S.1
Frankenberger, B.2
Schendel, D.3
-
122
-
-
77956222584
-
Generation of Th1-polarizing dendritic cells using the TLR7/8 agonist CL075
-
Spranger, S., Javorovic, M., Burdek, M., Wilde, S., Mosetter, B., Tippmer, S. et al. (2010) Generation of Th1-polarizing dendritic cells using the TLR7/8 agonist CL075. J Immunol 185: 738–747
-
(2010)
J Immunol
, vol.185
, pp. 738-747
-
-
Spranger, S.1
Javorovic, M.2
Burdek, M.3
Wilde, S.4
Mosetter, B.5
Tippmer, S.6
-
123
-
-
0037062920
-
Emerging clinical applications of RNA
-
Sullenger, B. and Gilboa, E. (2002) Emerging clinical applications of RNA. Nature 418: 252–258
-
(2002)
Nature
, vol.418
, pp. 252-258
-
-
Sullenger, B.1
Gilboa, E.2
-
124
-
-
36248966518
-
Induction of pluripotent stem cells from adult human fibroblasts by defined factors
-
Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K. et al. (2007) Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131: 861–872
-
(2007)
Cell
, vol.131
, pp. 861-872
-
-
Takahashi, K.1
Tanabe, K.2
Ohnuki, M.3
Narita, M.4
Ichisaka, T.5
Tomoda, K.6
-
125
-
-
33747195353
-
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
-
Takahashi, K. and Yamanaka, S. (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126: 663–676
-
(2006)
Cell
, vol.126
, pp. 663-676
-
-
Takahashi, K.1
Yamanaka, S.2
-
127
-
-
0026579897
-
Genetic immunization is a simple method for eliciting an immune response
-
Tang, D., DeVit, M. and Johnston, S. (1992) Genetic immunization is a simple method for eliciting an immune response. Nature 356: 152–154
-
(1992)
Nature
, vol.356
, pp. 152-154
-
-
Tang, D.1
Devit, M.2
Johnston, S.3
-
128
-
-
77950205047
-
Designing hypoallergenic derivatives for allergy treatment by means of in silico mutation and screening
-
Thalhamer, T., Dobias, H., Stepanoska, T., Proll, M., Stutz, H., Dissertori, O. et al. (2010) Designing hypoallergenic derivatives for allergy treatment by means of in silico mutation and screening. J Allergy Clin Immunol 125: 926–934 e910
-
(2010)
J Allergy Clin Immunol
, vol.125
-
-
Thalhamer, T.1
Dobias, H.2
Stepanoska, T.3
Proll, M.4
Stutz, H.5
Dissertori, O.6
-
129
-
-
0027411456
-
Heterologous protection against influenza by injection of DNA encoding a viral protein
-
Ulmer, J., Donnelly, J., Parker, S., Rhodes, G., Felgner, P., Dwarki, V. et al. (1993) Heterologous protection against influenza by injection of DNA encoding a viral protein. Science 259: 1745–1749
-
(1993)
Science
, vol.259
, pp. 1745-1749
-
-
Ulmer, J.1
Donnelly, J.2
Parker, S.3
Rhodes, G.4
Felgner, P.5
Dwarki, V.6
-
130
-
-
84862015339
-
RNA-based vaccines
-
Ulmer, J., Mason, P., Geall, A. and Mandl, C. (2012) RNA-based vaccines. Vaccine 30: 4414–4418
-
(2012)
Vaccine
, vol.30
, pp. 4414-4418
-
-
Ulmer, J.1
Mason, P.2
Geall, A.3
Mandl, C.4
-
131
-
-
47749129289
-
Improved induction of antibodies against key neutralizing epitopes by human immunodeficiency virus type 1 gp120 DNA prime-protein boost vaccination compared to gp120 protein-only vaccination
-
Vaine, M., Wang, S., Crooks, E., Jiang, P., Montefiori, D., Binley, J. et al. (2008) Improved induction of antibodies against key neutralizing epitopes by human immunodeficiency virus type 1 gp120 DNA prime-protein boost vaccination compared to gp120 protein-only vaccination. J Virol 82: 7369–7378
-
(2008)
J Virol
, vol.82
, pp. 7369-7378
-
-
Vaine, M.1
Wang, S.2
Crooks, E.3
Jiang, P.4
Montefiori, D.5
Binley, J.6
-
132
-
-
33748686759
-
Simultaneous activation of viral antigen-specific memory CD4+ and CD8+ T-cells using mRNAelectroporated CD40-activated autologous B-cells
-
Van den Bosch, G., Van Gulck, E., Ponsaerts, P., Nijs, G., Lenjou, M., Apers, L. et al. (2006) Simultaneous activation of viral antigen-specific memory CD4+ and CD8+ T-cells using mRNAelectroporated CD40-activated autologous B-cells. J Immunother 29: 512–523
-
(2006)
J Immunother
, vol.29
, pp. 512-523
-
-
Van Den Bosch, G.1
Van Gulck, E.2
Ponsaerts, P.3
Nijs, G.4
Lenjou, M.5
Apers, L.6
-
133
-
-
84857045791
-
MRNA-based dendritic cell vaccination induces potent antiviral T-cell responses in HIV-1- infected patients
-
Van Gulck, E., Vlieghe, E., Vekemans, M., Van Tendeloo, V., Van De Velde, A., Smits, E. et al. (2012) mRNA-based dendritic cell vaccination induces potent antiviral T-cell responses in HIV-1- infected patients. AIDS 26: F1–F12
-
(2012)
AIDS
, vol.26
-
-
Van Gulck, E.1
Vlieghe, E.2
Vekemans, M.3
Van Tendeloo, V.4
Van De Velde, A.5
Smits, E.6
-
134
-
-
84865830845
-
Can immunotherapy be useful as a ’functional cure‘ for infection with human immunodeficiency virus-1?
-
Vanham, G. and Van Gulck, E. (2012) Can immunotherapy be useful as a ’functional cure‘ for infection with human immunodeficiency virus-1? Retrovirology 9: 72
-
(2012)
Retrovirology
, vol.9
-
-
Vanham, G.1
Van Gulck, E.2
-
135
-
-
84859417996
-
Preclinical evaluation of TriMix and antigen mRNA-based antitumor therapy
-
Van Lint, S., Goyvaerts, C., Maenhout, S., Goethals, L., Disy, A., Benteyn, D. et al. (2012) Preclinical evaluation of TriMix and antigen mRNA-based antitumor therapy. Cancer Res 72: 1661–1671
-
(2012)
Cancer Res
, vol.72
, pp. 1661-1671
-
-
Van Lint, S.1
Goyvaerts, C.2
Maenhout, S.3
Goethals, L.4
Disy, A.5
Benteyn, D.6
-
136
-
-
84874724470
-
MRNA: From a chemical blueprint for protein production to an off-the-shelf therapeutic
-
Van Lint, S., Heirman, C., Thielemans, K. and Breckpot, K. (2013) mRNA: From a chemical blueprint for protein production to an off-the-shelf therapeutic. Hum Vaccin Immunother 9: 265–274
-
(2013)
Hum Vaccin Immunother
, vol.9
, pp. 265-274
-
-
Van Lint, S.1
Heirman, C.2
Thielemans, K.3
Breckpot, K.4
-
137
-
-
84862772889
-
Intravenous and intradermal TriMix-dendritic cell therapy results in a broad T-cell response and durable tumor response in a chemorefractory stage IV-M1c melanoma patient
-
Van Nuffel, A., Benteyn, D., Wilgenhof, S., Corthals, J., Heirman, C., Neyns, B. et al. (2012a) Intravenous and intradermal TriMix-dendritic cell therapy results in a broad T-cell response and durable tumor response in a chemorefractory stage IV-M1c melanoma patient. Cancer Immunol Immunother 61: 1033–1043
-
(2012)
Cancer Immunol Immunother
, vol.61
, pp. 1033-1043
-
-
Van Nuffel, A.1
Benteyn, D.2
Wilgenhof, S.3
Corthals, J.4
Heirman, C.5
Neyns, B.6
-
138
-
-
84860521660
-
Dendritic cells loaded with mRNA encoding full-length tumor antigens prime CD4+ and CD8+ T cells in melanoma patients
-
Van Nuffel, A., Benteyn, D., Wilgenhof, S., Pierret, L., Corthals, J., Heirman, C. et al. (2012b) Dendritic cells loaded with mRNA encoding full-length tumor antigens prime CD4+ and CD8+ T cells in melanoma patients. Mol Ther 20: 1063–1074
-
(2012)
Mol Ther
, vol.20
, pp. 1063-1074
-
-
Van Nuffel, A.1
Benteyn, D.2
Wilgenhof, S.3
Pierret, L.4
Corthals, J.5
Heirman, C.6
-
139
-
-
84886943603
-
Overcoming HLA restriction in clinical trials: Immune monitoring of mRNA-loaded DC therapy
-
Van Nuffel, A., Wilgenhof, S., Thielemans, K. and Bonehill, A. (2012c) Overcoming HLA restriction in clinical trials: Immune monitoring of mRNA-loaded DC therapy. Oncoimmunology 1: 1392–1394
-
(2012)
Oncoimmunology
, vol.1
, pp. 1392-1394
-
-
Van Nuffel, A.1
Wilgenhof, S.2
Thielemans, K.3
Bonehill, A.4
-
140
-
-
84875490185
-
Cancer genome landscapes
-
Vogelstein, B., Papadopoulos, N., Velculescu, V., Zhou, S., Diaz, L., Jr and Kinzler, K. (2013) Cancer genome landscapes. Science 339: 1546–1558
-
(2013)
Science
, vol.339
, pp. 1546-1558
-
-
Vogelstein, B.1
Papadopoulos, N.2
Velculescu, V.3
Zhou, S.4
Diaz, L.5
Kinzler, K.6
-
141
-
-
79957815743
-
Reshaping the Bet v 1 fold modulates T(H) polarization
-
Wallner, M., Hauser, M., Himly, M., Zaborsky, N., Mutschlechner, S., Harrer, A. et al. (2011) Reshaping the Bet v 1 fold modulates T(H) polarization. J Allergy Clin Immunol 127: 1571–1578 e1579
-
(2011)
J Allergy Clin Immunol
, vol.127
-
-
Wallner, M.1
Hauser, M.2
Himly, M.3
Zaborsky, N.4
Mutschlechner, S.5
Harrer, A.6
-
142
-
-
84862291971
-
Toll-like receptor 7 is required for effective adaptive immune responses that prevent persistent virus infection
-
Walsh, K., Teijaro, J., Zuniga, E., Welch, M., Fremgen, D., Blackburn, S. et al. (2012) Toll-like receptor 7 is required for effective adaptive immune responses that prevent persistent virus infection. Cell Host Microbe 11: 643–653
-
(2012)
Cell Host Microbe
, vol.11
, pp. 643-653
-
-
Walsh, K.1
Teijaro, J.2
Zuniga, E.3
Welch, M.4
Fremgen, D.5
Blackburn, S.6
-
143
-
-
84864662070
-
Multipeptide immune response to cancer vaccine IMA901 after single-dose cyclophosphamide associates with longer patient survival
-
Walter, S., Weinschenk, T., Stenzl, A., Zdrojowy, R., Pluzanska, A., Szczylik, C. et al. (2012) Multipeptide immune response to cancer vaccine IMA901 after single-dose cyclophosphamide associates with longer patient survival. Nat Med 18: 1254–1261
-
(2012)
Nat Med
, vol.18
, pp. 1254-1261
-
-
Walter, S.1
Weinschenk, T.2
Stenzl, A.3
Zdrojowy, R.4
Pluzanska, A.5
Szczylik, C.6
-
144
-
-
84869802293
-
Pilot study on the immunogenicity of paired Env immunogens from mother-to-child transmitted HIV-1 isolates
-
Wang, S., Kishko, M., Wan, S., Wang, Y., Brewster, F., Gray, G. et al. (2012) Pilot study on the immunogenicity of paired Env immunogens from mother-to-child transmitted HIV-1 isolates. Hum Vaccin Immunother 8: 1638–1647
-
(2012)
Hum Vaccin Immunother
, vol.8
, pp. 1638-1647
-
-
Wang, S.1
Kishko, M.2
Wan, S.3
Wang, Y.4
Brewster, F.5
Gray, G.6
-
145
-
-
77958536106
-
Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA
-
Warren, L., Manos, P., Ahfeldt, T., Loh, Y., Li, H., Lau, F. et al. (2010) Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell 7: 618–630
-
(2010)
Cell Stem Cell
, vol.7
, pp. 618-630
-
-
Warren, L.1
Manos, P.2
Ahfeldt, T.3
Loh, Y.4
Li, H.5
Lau, F.6
-
146
-
-
44949195901
-
Results of the first phase I/II clinical vaccination trial with direct injection of mRNA
-
Weide, B., Carralot, J., Reese, A., Scheel, B., Eigentler, T., Hoerr, I. et al. (2008) Results of the first phase I/II clinical vaccination trial with direct injection of mRNA. J Immunother 31: 180–188
-
(2008)
J Immunother
, vol.31
, pp. 180-188
-
-
Weide, B.1
Carralot, J.2
Reese, A.3
Scheel, B.4
Eigentler, T.5
Hoerr, I.6
-
147
-
-
67651152679
-
Direct injection of protamine-protected mRNA: Results of a phase 1/2 vaccination trial in metastatic melanoma patients
-
Weide, B., Pascolo, S., Scheel, B., Derhovanessian, E., Pflugfelder, A., Eigentler, T. et al. (2009) Direct injection of protamine-protected mRNA: results of a phase 1/2 vaccination trial in metastatic melanoma patients. J Immunother 32: 498–507
-
(2009)
J Immunother
, vol.32
, pp. 498-507
-
-
Weide, B.1
Pascolo, S.2
Scheel, B.3
Derhovanessian, E.4
Pflugfelder, A.5
Eigentler, T.6
-
148
-
-
83155183302
-
MRNA vaccination as a safe approach for specific protection from type I allergy
-
Weiss, R., Scheiblhofer, S., Roesler, E., Weinberger, E. and Thalhamer, J. (2012) mRNA vaccination as a safe approach for specific protection from type I allergy. Expert Rev Vaccines 11: 55–67
-
(2012)
Expert Rev Vaccines
, vol.11
, pp. 55-67
-
-
Weiss, R.1
Scheiblhofer, S.2
Roesler, E.3
Weinberger, E.4
Thalhamer, J.5
-
150
-
-
0037383592
-
Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment
-
Wherry, E., Blattman, J., Murali-Krishna, K., van der Most, R. and Ahmed, R. (2003) Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment. J Virol 77: 4911–4927
-
(2003)
J Virol
, vol.77
, pp. 4911-4927
-
-
Wherry, E.1
Blattman, J.2
Murali-Krishna, K.3
Van Der Most, R.4
Ahmed, R.5
-
151
-
-
0025338173
-
How the messenger got its tail: Addition of poly(A) in the nucleus
-
Wickens, M. (1990) How the messenger got its tail: addition of poly(A) in the nucleus. Trends Biochem Sci 15: 277–281
-
(1990)
Trends Biochem Sci
, vol.15
, pp. 277-281
-
-
Wickens, M.1
-
152
-
-
79952984337
-
Restoration of tumor equilibrium after immunotherapy for advanced melanoma: Three illustrative cases
-
Wilgenhof, S., Pierret, L., Corthals, J., Van Nuffel, A., Heirman, C., Roelandt, T. et al. (2011a) Restoration of tumor equilibrium after immunotherapy for advanced melanoma: three illustrative cases. Melanoma Res 21: 152–159
-
(2011)
Melanoma Res
, vol.21
, pp. 152-159
-
-
Wilgenhof, S.1
Pierret, L.2
Corthals, J.3
Van Nuffel, A.4
Heirman, C.5
Roelandt, T.6
-
153
-
-
79957904174
-
Therapeutic vaccination with an autologous mRNA electroporated dendritic cell vaccine in patients with advanced melanoma
-
Wilgenhof, S., Van Nuffel, A., Corthals, J., Heirman, C., Tuyaerts, S., Benteyn, D. et al. (2011b) Therapeutic vaccination with an autologous mRNA electroporated dendritic cell vaccine in patients with advanced melanoma. J Immunother 34: 448–456
-
(2011)
J Immunother
, vol.34
, pp. 448-456
-
-
Wilgenhof, S.1
Van Nuffel, A.2
Corthals, J.3
Heirman, C.4
Tuyaerts, S.5
Benteyn, D.6
-
154
-
-
84884721824
-
Phase IB study on intravenous synthetic mRNA electroporated dendritic cell immunotherapy in pretreated advanced melanoma patients
-
Wilgenhof, S., Van Nuffel, A., Benteyn, D., Corthals, J., Aerts, C., Heirman, C. et al. (2013) Phase IB study on intravenous synthetic mRNA electroporated dendritic cell immunotherapy in pretreated advanced melanoma patients. Ann Oncol 24: 2686–2693
-
(2013)
Ann Oncol
, vol.24
, pp. 2686-2693
-
-
Wilgenhof, S.1
Van Nuffel, A.2
Benteyn, D.3
Corthals, J.4
Aerts, C.5
Heirman, C.6
-
155
-
-
0025231388
-
Direct gene transfer into mouse muscle in vivo
-
Wolff, J., Malone, R., Williams, P., Chong, W., Acsadi, G., Jani, A. et al. (1990) Direct gene transfer into mouse muscle in vivo. Science 247: 1465–1468
-
(1990)
Science
, vol.247
, pp. 1465-1468
-
-
Wolff, J.1
Malone, R.2
Williams, P.3
Chong, W.4
Acsadi, G.5
Jani, A.6
-
156
-
-
18744409038
-
Plasmacytoid dendritic cells: A new cutaneous dendritic cell subset with distinct role in inflammatory skin diseases
-
Wollenberg, A., Wagner, M., Gunther, S., Towarowski, A., Tuma, E., Moderer, M. et al. (2002) Plasmacytoid dendritic cells: a new cutaneous dendritic cell subset with distinct role in inflammatory skin diseases. J Invest Dermatol 119: 1096–1102
-
(2002)
J Invest Dermatol
, vol.119
, pp. 1096-1102
-
-
Wollenberg, A.1
Wagner, M.2
Gunther, S.3
Towarowski, A.4
Tuma, E.5
Moderer, M.6
-
157
-
-
0024514346
-
Sindbis virus: An efficient, broad host range vector for gene expression in animal cells
-
Xiong, C., Levis, R., Shen, P., Schlesinger, S., Rice, C. and Huang, H. (1989) Sindbis virus: an efficient, broad host range vector for gene expression in animal cells. Science 243: 1188–1191
-
(1989)
Science
, vol.243
, pp. 1188-1191
-
-
Xiong, C.1
Levis, R.2
Shen, P.3
Schlesinger, S.4
Rice, C.5
Huang, H.6
-
158
-
-
77949793550
-
Reprogramming of human fibroblasts to pluripotent stem cells using mRNA of four transcription factors
-
Yakubov, E., Rechavi, G., Rozenblatt, S. and Givol, D. (2010) Reprogramming of human fibroblasts to pluripotent stem cells using mRNA of four transcription factors. Biochem Biophys Res Commun 394: 189–193
-
(2010)
Biochem Biophys Res Commun
, vol.394
, pp. 189-193
-
-
Yakubov, E.1
Rechavi, G.2
Rozenblatt, S.3
Givol, D.4
-
159
-
-
36749043230
-
Induced pluripotent stem cell lines derived from human somatic cells
-
Yu, J., Vodyanik, M., Smuga-Otto, K., Antosiewicz- Bourget, J., Frane, J., Tian, S. et al. (2007) Induced pluripotent stem cell lines derived from human somatic cells. Science 318: 1917–1920
-
(2007)
Science
, vol.318
, pp. 1917-1920
-
-
Yu, J.1
Vodyanik, M.2
Smuga-Otto, K.3
Antosiewicz- Bourget, J.4
Frane, J.5
Tian, S.6
-
160
-
-
84885676364
-
Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction
-
8 September, Epub ahead of print
-
Zangi, L., Lui, K., von Gise, A., Ma, Q., Ebina, W., Ptaszek, L. et al. (2013) Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction. Nat Biotechnol 8 September (Epub ahead of print).
-
(2013)
Nat Biotechnol
-
-
Zangi, L.1
Lui, K.2
Von Gise, A.3
Ma, Q.4
Ebina, W.5
Ptaszek, L.6
-
161
-
-
0028173338
-
Self-replicating Semliki Forest virus RNA as recombinant vaccine
-
Zhou, X., Berglund, P., Rhodes, G., Parker, S., Jondal, M. and Liljeström, P. (1994) Self-replicating Semliki Forest virus RNA as recombinant vaccine. Vaccine 12: 1510–1514.
-
(1994)
Vaccine
, vol.12
, pp. 1510-1514
-
-
Zhou, X.1
Berglund, P.2
Rhodes, G.3
Parker, S.4
Jondal, M.5
Liljeström, P.6
|