메뉴 건너뛰기




Volumn 2, Issue 1, 2014, Pages 10-31

A development that may evolve into a revolution in medicine: MRNA as the basis for novel, nucleotide-based vaccines and drugs

Author keywords

MRNA based vaccines; Replicons; RNActive vaccines; Therapeutic mRNA

Indexed keywords


EID: 84921025620     PISSN: 20510136     EISSN: None     Source Type: Journal    
DOI: 10.1177/2051013613508729     Document Type: Review
Times cited : (88)

References (161)
  • 2
    • 0036196564 scopus 로고    scopus 로고
    • Kunjin virus replicon vaccine vectors induce protective CD8+ T-cell immunity
    • Anraku, I., Harvey, T., Linedale, R., Gardner, J., Harrich, D., Suhrbier, A. et al. (2002) Kunjin virus replicon vaccine vectors induce protective CD8+ T-cell immunity. J Virol 76: 3791–3799
    • (2002) J Virol , vol.76 , pp. 3791-3799
    • Anraku, I.1    Harvey, T.2    Linedale, R.3    Gardner, J.4    Harrich, D.5    Suhrbier, A.6
  • 3
    • 80053353462 scopus 로고    scopus 로고
    • Innate and adaptive immune responses to viral infection and vaccination
    • Aoshi, T., Koyama, S., Kobiyama, K., Akira, S. and Ishii, K.J. (2011) Innate and adaptive immune responses to viral infection and vaccination. Curr Opin Virol 1: 226–232
    • (2011) Curr Opin Virol , vol.1 , pp. 226-232
    • Aoshi, T.1    Koyama, S.2    Kobiyama, K.3    Akira, S.4    Ishii, K.J.5
  • 4
    • 84867437406 scopus 로고    scopus 로고
    • Immunotherapy against HPV16/18 generates potent TH1 and cytotoxic cellular immune responses
    • Bagarazzi, M., Yan, J., Morrow, M., Shen, X., Parker, R., Lee, J. et al. (2012) Immunotherapy against HPV16/18 generates potent TH1 and cytotoxic cellular immune responses. Sci Transl Med 4: 155ra138
    • (2012) Sci Transl Med , vol.4
    • Bagarazzi, M.1    Yan, J.2    Morrow, M.3    Shen, X.4    Parker, R.5    Lee, J.6
  • 5
    • 0019276997 scopus 로고
    • 5′-terminal cap structure in eucaryotic messenger ribonucleic acids
    • Banerjee, A. (1980) 5′-terminal cap structure in eucaryotic messenger ribonucleic acids. Microbiol Rev 44: 175–205
    • (1980) Microbiol Rev , vol.44 , pp. 175-205
    • Anerjee, A.1
  • 6
    • 49649120397 scopus 로고    scopus 로고
    • Tumor regression in cancer patients by very low doses of a T cell-engaging antibody
    • Bargou, R., Leo, E., Zugmaier, G., Klinger, M., Goebeler, M., Knop, S. et al. (2008) Tumor regression in cancer patients by very low doses of a T cell-engaging antibody. Science 321: 974–977
    • (2008) Science , vol.321 , pp. 974-977
    • Bargou, R.1    Leo, E.2    Zugmaier, G.3    Klinger, M.4    Goebeler, M.5    Knop, S.6
  • 7
    • 33745370080 scopus 로고    scopus 로고
    • Generation of hypoallergenic DNA vaccines by forced ubiquitination: Preventive and therapeutic effects in a mouse model of allergy
    • Bauer, R., Scheiblhofer, S., Kern, K., Gruber, C., Stepanoska, T., Thalhamer, T. et al. (2006) Generation of hypoallergenic DNA vaccines by forced ubiquitination: preventive and therapeutic effects in a mouse model of allergy. J Allergy Clin Immunol 118: 269–276
    • (2006) J Allergy Clin Immunol , vol.118 , pp. 269-276
    • Bauer, R.1    Scheiblhofer, S.2    Kern, K.3    Gruber, C.4    Stepanoska, T.5    Thalhamer, T.6
  • 8
    • 77952238515 scopus 로고    scopus 로고
    • A phase 2 study of high-dose Allovectin-7 in patients with advanced metastatic melanoma
    • Bedikian, A., Richards, J., Kharkevitch, D., Atkins, M., Whitman, E. and Gonzalez, R. (2010) A phase 2 study of high-dose Allovectin-7 in patients with advanced metastatic melanoma. Melanoma Res 20: 218–226
    • (2010) Melanoma Res , vol.20 , pp. 218-226
    • Bedikian, A.1    Richards, J.2    Kharkevitch, D.3    Atkins, M.4    Whitman, E.5    Gonzalez, R.6
  • 9
    • 84870455276 scopus 로고    scopus 로고
    • Anti-TNF-alpha biotherapies: Perspectives for evidence-based personalized medicine
    • Bendtzen, K. (2012) Anti-TNF-alpha biotherapies: perspectives for evidence-based personalized medicine. Immunotherapy 4: 1167–1179
    • (2012) Immunotherapy , vol.4 , pp. 1167-1179
    • Bendtzen, K.1
  • 10
    • 84874640769 scopus 로고    scopus 로고
    • Characterization of CD8+ T-cell responses in the peripheral blood and skin injection sites of melanoma patients treated with mRNA electroporated autologous dendritic cells (TriMixDC-MEL)
    • Benteyn, D., Van Nuffel, A., Wilgenhof, S., Corthals, J., Heirman, C., Neyns, B. et al. (2013) Characterization of CD8+ T-cell responses in the peripheral blood and skin injection sites of melanoma patients treated with mRNA electroporated autologous dendritic cells (TriMixDC-MEL). Biomed Res Int 2013: 976383
    • (2013) Biomed Res Int , vol.2013
    • Benteyn, D.1    Van Nuffel, A.2    Wilgenhof, S.3    Corthals, J.4    Heirman, C.5    Neyns, B.6
  • 11
    • 0033524647 scopus 로고    scopus 로고
    • Immunization with recombinant Semliki Forest virus induces protection against influenza challenge in mice
    • Berglund, P., Fleeton, M., Smerdou, C. and Liljeström, P. (1999) Immunization with recombinant Semliki Forest virus induces protection against influenza challenge in mice. Vaccine 17: 497–507
    • (1999) Vaccine , vol.17 , pp. 497-507
    • Berglund, P.1    Fleeton, M.2    Smerdou, C.3    Liljeström, P.4
  • 13
    • 85042889314 scopus 로고    scopus 로고
    • Topical SMIP-7.7, a tolllike receptor 7 agonist, protects against genital herpes simplex virus-2 disease in the guinea pig model of genital herpes
    • 12 December, Epub ahead of print
    • Bernstein, D., Cardin, R., Bravo, F., Earwood, J., Clark, J., Li, Y. et al. (2012) Topical SMIP-7.7, a tolllike receptor 7 agonist, protects against genital herpes simplex virus-2 disease in the guinea pig model of genital herpes. Antivir Chem Chemother 12 December (Epub ahead of print).
    • (2012) Antivir Chem Chemother
    • Bernstein, D.1    Cardin, R.2    Bravo, F.3    Earwood, J.4    Clark, J.5    Li, Y.6
  • 14
    • 84869091997 scopus 로고    scopus 로고
    • Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes
    • Biankin, A., Waddell, N., Kassahn, K., Gingras, M., Muthuswamy, L., Johns, A. et al. (2012) Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature 491: 399–405
    • (2012) Nature , vol.491 , pp. 399-405
    • Biankin, A.1    Waddell, N.2    Kassahn, K.3    Gingras, M.4    Muthuswamy, L.5    Johns, A.6
  • 15
    • 0029839058 scopus 로고    scopus 로고
    • Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo
    • Boczkowski, D., Nair, S., Snyder, D. and Gilboa, E. (1996) Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo. J Exp Med 184: 465–472
    • (1996) J Exp Med , vol.184 , pp. 465-472
    • Boczkowski, D.1    Nair, S.2    Snyder, D.3    Gilboa, E.4
  • 16
    • 0141592713 scopus 로고    scopus 로고
    • Efficient presentation of known HLA class II-restricted MAGE-A3 epitopes by dendritic cells electroporated with messenger RNA encoding an invariant chain with genetic exchange of class II-associated invariant chain peptide
    • Bonehill, A., Heirman, C., Tuyaerts, S., Michiels, A., Zhang, Y., van der Bruggen, P. et al. (2003) Efficient presentation of known HLA class II-restricted MAGE-A3 epitopes by dendritic cells electroporated with messenger RNA encoding an invariant chain with genetic exchange of class II-associated invariant chain peptide. Cancer Res 63: 5587–5594
    • (2003) Cancer Res , vol.63 , pp. 5587-5594
    • Bonehill, A.1    Heirman, C.2    Tuyaerts, S.3    Michiels, A.4    Zhang, Y.5    Van Der Bruggen, P.6
  • 17
    • 44349173032 scopus 로고    scopus 로고
    • Enhancing the T-cell stimulatory capacity of human dendritic cells by co-electroporation with CD40L, CD70 and constitutively active TLR4 encoding mRNA
    • Bonehill, A., Tuyaerts, S., Van Nuffel, A., Heirman, C., Bos, T., Fostier, K. et al. (2008) Enhancing the T-cell stimulatory capacity of human dendritic cells by co-electroporation with CD40L, CD70 and constitutively active TLR4 encoding mRNA. Mol Ther 16: 1170–1180
    • (2008) Mol Ther , vol.16 , pp. 1170-1180
    • Bonehill, A.1    Tuyaerts, S.2    Van Nuffel, A.3    Heirman, C.4    Bos, T.5    Fostier, K.6
  • 19
    • 13644263475 scopus 로고    scopus 로고
    • Exploiting dendritic cells for cancer immunotherapy: Genetic modification of dendritic cells
    • Breckpot, K., Heirman, C., Neyns, B. and Thielemans, K. (2004) Exploiting dendritic cells for cancer immunotherapy: genetic modification of dendritic cells. J Gene Med 6: 1175–1188
    • (2004) J Gene Med , vol.6 , pp. 1175-1188
    • Breckpot, K.1    Heirman, C.2    Neyns, B.3    Thielemans, K.4
  • 22
    • 0028965192 scopus 로고
    • Characterization of a messenger RNA polynucleotide vaccine vector
    • Conry, R., LoBuglio, A., Wright, M., Sumerel, L., Pike, M., Johanning, F. et al. (1995) Characterization of a messenger RNA polynucleotide vaccine vector. Cancer Res 55: 1397–1400
    • (1995) Cancer Res , vol.55 , pp. 1397-1400
    • Conry, R.1    Lobuglio, A.2    Wright, M.3    Sumerel, L.4    Pike, M.5    Johanning, F.6
  • 23
    • 0035051928 scopus 로고    scopus 로고
    • West Nile virus recombinant DNA vaccine protects mouse and horse from virus challenge and expresses in vitro a noninfectious recombinant antigen that can be used in enzyme-linked immunosorbent assays
    • Davis, B., Chang, G., Cropp, B., Roehrig, J., Martin, D., Mitchell, C. et al. (2001) West Nile virus recombinant DNA vaccine protects mouse and horse from virus challenge and expresses in vitro a noninfectious recombinant antigen that can be used in enzyme-linked immunosorbent assays. J Virol 75: 4040–4047
    • (2001) J Virol , vol.75 , pp. 4040-4047
    • Davis, B.1    Chang, G.2    Cropp, B.3    Roehrig, J.4    Martin, D.5    Mitchell, C.6
  • 24
    • 84890553500 scopus 로고    scopus 로고
    • Preclinical comparison of near-infrared-labeled cetuximab and panitumumab for optical imaging of head and neck squamous cell carcinoma
    • 29 May, Epub ahead of print
    • Day, K., Sweeny, L., Kulbersh, B., Zinn, K. and Rosenthal, E. (2013) Preclinical comparison of near-infrared-labeled cetuximab and panitumumab for optical imaging of head and neck squamous cell carcinoma. Mol Imaging Biol 29 May (Epub ahead of print).
    • (2013) Mol Imaging Biol
    • Day, K.1    Sweeny, L.2    Kulbersh, B.3    Zinn, K.4    Rosenthal, E.5
  • 25
    • 84862855875 scopus 로고    scopus 로고
    • Nucleic acid sensing at the interface between innate and adaptive immunity in vaccination
    • Desmet, C. and Ishii, K. (2012) Nucleic acid sensing at the interface between innate and adaptive immunity in vaccination. Nat Rev Immunol 12: 479–491
    • (2012) Nat Rev Immunol , vol.12 , pp. 479-491
    • Desmet, C.1    Ishii, K.2
  • 26
    • 80355147292 scopus 로고    scopus 로고
    • Type I interferon is selectively required by dendritic cells for immune rejection of tumors
    • Diamond, M., Kinder, M., Matsushita, H., Mashayekhi, M., Dunn, G., Archambault, J. et al. (2011) Type I interferon is selectively required by dendritic cells for immune rejection of tumors. J Exp Med 208: 1989–2003
    • (2011) J Exp Med , vol.208 , pp. 1989-2003
    • Diamond, M.1    Kinder, M.2    Matsushita, H.3    Mashayekhi, M.4    Dunn, G.5    Archambault, J.6
  • 28
    • 79960145796 scopus 로고    scopus 로고
    • Selective uptake of naked vaccine RNA by dendritic cells is driven by macropinocytosis and abrogated upon DC maturation
    • Diken, M., Kreiter, S., Selmi, A., Britten, C., Huber, C., Tureci, O. et al. (2011) Selective uptake of naked vaccine RNA by dendritic cells is driven by macropinocytosis and abrogated upon DC maturation. Gene Ther 18: 702–708
    • (2011) Gene Ther , vol.18 , pp. 702-708
    • Diken, M.1    Kreiter, S.2    Selmi, A.3    Britten, C.4    Huber, C.5    Tureci, O.6
  • 29
    • 84878642106 scopus 로고    scopus 로고
    • Antitumor vaccination with synthetic mRNA: Strategies for in vitro and in vivo preclinical studies
    • Diken, M., Kreiter, S., Selmi, A., Tureci, O. and Sahin, U. (2013) Antitumor vaccination with synthetic mRNA: strategies for in vitro and in vivo preclinical studies. Methods Mol Biol 969: 235–246
    • (2013) Methods Mol Biol , vol.969 , pp. 235-246
    • Diken, M.1    Kreiter, S.2    Selmi, A.3    Tureci, O.4    Sahin, U.5
  • 30
    • 0029655275 scopus 로고    scopus 로고
    • Sindbis virus DNA-based expression vectors: Utility for in vitro and in vivo gene transfer
    • Dubensky, T., Jr, Driver, D., Polo, J., Belli, B., Latham, E., Ibanez, C. et al. (1996) Sindbis virus DNA-based expression vectors: utility for in vitro and in vivo gene transfer. J Virol 70: 508–519
    • (1996) J Virol , vol.70 , pp. 508-519
    • Dubensky, T.1    Driver, D.2    Polo, J.3    Belli, B.4    Latham, E.5    Ibanez, C.6
  • 31
    • 2542430341 scopus 로고    scopus 로고
    • The three Es of cancer immunoediting
    • Dunn, G., Old, L. and Schreiber, R. (2004) The three Es of cancer immunoediting. Annu Rev Immunol 22: 329–360
    • (2004) Annu Rev Immunol , vol.22 , pp. 329-360
    • Dunn, G.1    Old, L.2    Schreiber, R.3
  • 32
    • 84884365634 scopus 로고    scopus 로고
    • Inducing humoral and cellular responses to multiple sporozoite and liver stage malaria antigens using pDNA
    • Ferraro, B., Talbott, K., Balakrishnan, A., Cisper, N., Morrow, M., Hutnick, N. et al. (2013) Inducing humoral and cellular responses to multiple sporozoite and liver stage malaria antigens using pDNA. Infect Immun 81: 3709–3720
    • (2013) Infect Immun , vol.81 , pp. 3709-3720
    • Ferraro, B.1    Talbott, K.2    Balakrishnan, A.3    Cisper, N.4    Morrow, M.5    Hutnick, N.6
  • 33
    • 85042887646 scopus 로고    scopus 로고
    • Europe risks ‘vaccine fatigue’
    • 8 October
    • Finnegan, G. (2012) Europe risks ‘vaccine fatigue’. Vaccines today 8 October.
    • (2012) Vaccines Today
    • Finnegan, G.1
  • 34
    • 0035341935 scopus 로고    scopus 로고
    • Self-replicative RNA vaccines elicit protection against influenza A virus, respiratory syncytial virus, and a tickborne encephalitis virus
    • Fleeton, M., Chen, M., Berglund, P., Rhodes, G., Parker, S., Murphy, M. et al. (2001) Self-replicative RNA vaccines elicit protection against influenza A virus, respiratory syncytial virus, and a tickborne encephalitis virus. J Infect Dis 183: 1395–1398
    • (2001) J Infect Dis , vol.183 , pp. 1395-1398
    • Fleeton, M.1    Chen, M.2    Berglund, P.3    Rhodes, G.4    Parker, S.5    Murphy, M.6
  • 35
    • 0033981840 scopus 로고    scopus 로고
    • Recombinant Semliki Forest virus particles expressing louping ill virus antigens induce a better protective response than plasmid-based DNA vaccines or an inactivated whole particle vaccine
    • Fleeton, M., Liljeström, P., Sheahan, B. and Atkins, G. (2000) Recombinant Semliki Forest virus particles expressing louping ill virus antigens induce a better protective response than plasmid-based DNA vaccines or an inactivated whole particle vaccine. J Gen Virol 81: 749–758
    • (2000) J Gen Virol , vol.81 , pp. 749-758
    • Fleeton, M.1    Liljeström, P.2    Sheahan, B.3    Atkins, G.4
  • 36
    • 78650640612 scopus 로고    scopus 로고
    • Messenger RNA-based vaccines with dual activity induce balanced TLR-7 dependent adaptive immune responses and provide antitumor activity
    • Fotin-Mleczek, M., Duchardt, K., Lorenz, C., Pfeiffer, R., Ojkic-Zrna, S., Probst, J. et al. (2011) Messenger RNA-based vaccines with dual activity induce balanced TLR-7 dependent adaptive immune responses and provide antitumor activity. J Immunother 34: 1–15
    • (2011) J Immunother , vol.34 , pp. 1-15
    • Fotin-Mleczek, M.1    Duchardt, K.2    Lorenz, C.3    Pfeiffer, R.4    Ojkic-Zrna, S.5    Probst, J.6
  • 37
    • 84862891254 scopus 로고    scopus 로고
    • Highly potent mRNA based cancer vaccines represent an attractive platform for combination therapies supporting an improved therapeutic effect
    • Fotin-Mleczek, M., Zanzinger, K., Heidenreich, R., Lorenz, C., Thess, A., Duchardt, K. et al. (2012) Highly potent mRNA based cancer vaccines represent an attractive platform for combination therapies supporting an improved therapeutic effect. J Gene Med 14: 428–439
    • (2012) J Gene Med , vol.14 , pp. 428-439
    • Fotin-Mleczek, M.1    Zanzinger, K.2    Heidenreich, R.3    Lorenz, C.4    Thess, A.5    Duchardt, K.6
  • 38
    • 18444409072 scopus 로고    scopus 로고
    • Efficacy of an infectious hematopoietic necrosis (IHN) virus DNA vaccine in Chinook Oncorhynchus tshawytscha and sockeye O. nerka salmon
    • Garver, K., LaPatra, S. and Kurath, G. (2005) Efficacy of an infectious hematopoietic necrosis (IHN) virus DNA vaccine in Chinook Oncorhynchus tshawytscha and sockeye O. nerka salmon. Dis Aquat Organ 64: 13–22
    • (2005) Dis Aquat Organ , vol.64 , pp. 13-22
    • Garver, K.1    Lapatra, S.2    Kurath, G.3
  • 39
    • 84882259948 scopus 로고    scopus 로고
    • RNA: The new revolution in nucleic acid vaccines
    • Geall, A., Mandl, C. and Ulmer, J. (2013) RNA: The new revolution in nucleic acid vaccines. Semin Immunol 25: 152–159
    • (2013) Semin Immunol , vol.25 , pp. 152-159
    • Geall, A.1    Mandl, C.2    Ulmer, J.3
  • 41
    • 34248204110 scopus 로고    scopus 로고
    • DC-based cancer vaccines
    • Gilboa, E. (2007) DC-based cancer vaccines. J Clin Invest 117: 1195–1203
    • (2007) J Clin Invest , vol.117 , pp. 1195-1203
    • Gilboa, E.1
  • 42
    • 84859393296 scopus 로고    scopus 로고
    • MRNA leapfrogs DNA to show promise for therapeutic gene transfer
    • Gilboa, E. (2012) mRNA leapfrogs DNA to show promise for therapeutic gene transfer. Mol Ther 20: 694–695
    • (2012) Mol Ther , vol.20 , pp. 694-695
    • Gilboa, E.1
  • 43
    • 2942559009 scopus 로고    scopus 로고
    • Cancer immunotherapy with mRNA-transfected dendritic cells
    • Gilboa, E. and Vieweg, J. (2004) Cancer immunotherapy with mRNA-transfected dendritic cells. Immunol Rev 199: 251–263
    • (2004) Immunol Rev , vol.199 , pp. 251-263
    • Gilboa, E.1    Vieweg, J.2
  • 44
    • 40049101678 scopus 로고    scopus 로고
    • IgE in allergy and asthma today
    • Gould, H. and Sutton, B. (2008) IgE in allergy and asthma today. Nat Rev Immunol 8: 205–217
    • (2008) Nat Rev Immunol , vol.8 , pp. 205-217
    • Gould, H.1    Sutton, B.2
  • 45
    • 82755181916 scopus 로고    scopus 로고
    • Safety and efficacy of a xenogeneic DNA vaccine encoding for human tyrosinase as adjunctive treatment for oral malignant melanoma in dogs following surgical excision of the primary tumor
    • Grosenbaugh, D., Leard, A., Bergman, P., Klein, M., Meleo, K., Susaneck, S. et al. (2011) Safety and efficacy of a xenogeneic DNA vaccine encoding for human tyrosinase as adjunctive treatment for oral malignant melanoma in dogs following surgical excision of the primary tumor. Am J Vet Res 72: 1631–1638
    • (2011) Am J Vet Res , vol.72 , pp. 1631-1638
    • Grosenbaugh, D.1    Leard, A.2    Bergman, P.3    Klein, M.4    Meleo, K.5    Susaneck, S.6
  • 46
    • 79959196581 scopus 로고    scopus 로고
    • Immunotherapy for prostate cancer: Recent advances, lessons learned, and areas for further research
    • Gulley, J. and Drake, C. (2011) Immunotherapy for prostate cancer: recent advances, lessons learned, and areas for further research. Clin Cancer Res 17: 3884–3891
    • (2011) Clin Cancer Res , vol.17 , pp. 3884-3891
    • Gulley, J.1    Drake, C.2
  • 47
    • 78650583401 scopus 로고    scopus 로고
    • Role of antigen persistence and dose for CD4+ T-cell exhaustion and recovery
    • Han, S., Asoyan, A., Rabenstein, H., Nakano, N. and Obst, R. (2010) Role of antigen persistence and dose for CD4+ T-cell exhaustion and recovery. Proc Natl Acad Sci U S A 107: 20453–20458
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 20453-20458
    • Han, S.1    Asoyan, A.2    Rabenstein, H.3    Nakano, N.4    Obst, R.5
  • 48
    • 71449109765 scopus 로고    scopus 로고
    • Direct cell reprogramming is a stochastic process amenable to acceleration
    • Hanna, J., Saha, K., Pando, B., van Zon, J., Lengner, C., Creyghton, M. et al. (2009) Direct cell reprogramming is a stochastic process amenable to acceleration. Nature 462: 595–601
    • (2009) Nature , vol.462 , pp. 595-601
    • Hanna, J.1    Saha, K.2    Pando, B.3    Van Zon, J.4    Lengner, C.5    Creyghton, M.6
  • 49
    • 0031882102 scopus 로고    scopus 로고
    • DNA immunization against herpes simplex virus: Enhanced efficacy using a Sindbis virus-based vector
    • Hariharan, M., Driver, D., Townsend, K., Brumm, D., Polo, J., Belli, B. et al. (1998) DNA immunization against herpes simplex virus: enhanced efficacy using a Sindbis virus-based vector. J Virol 72: 950–958
    • (1998) J Virol , vol.72 , pp. 950-958
    • Hariharan, M.1    Driver, D.2    Townsend, K.3    Brumm, D.4    Polo, J.5    Belli, B.6
  • 51
    • 0141953994 scopus 로고    scopus 로고
    • Identification and functional analysis of tumorinfiltrating plasmacytoid dendritic cells in head and neck cancer
    • Hartmann, E., Wollenberg, B., Rothenfusser, S., Wagner, M., Wellisch, D., Mack, B. et al. (2003) Identification and functional analysis of tumorinfiltrating plasmacytoid dendritic cells in head and neck cancer. Cancer Res 63: 6478–6487
    • (2003) Cancer Res , vol.63 , pp. 6478-6487
    • Hartmann, E.1    Wollenberg, B.2    Rothenfusser, S.3    Wagner, M.4    Wellisch, D.5    Mack, B.6
  • 53
    • 39449094869 scopus 로고    scopus 로고
    • T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation
    • Henrickson, S., Mempel, T., Mazo, I., Liu, B., Artyomov, M., Zheng, H. et al. (2008) T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation. Nat Immunol 9: 282–291
    • (2008) Nat Immunol , vol.9 , pp. 282-291
    • Henrickson, S.1    Mempel, T.2    Mazo, I.3    Liu, B.4    Artyomov, M.5    Zheng, H.6
  • 54
    • 0033989908 scopus 로고    scopus 로고
    • In vivo application of RNA leads to induction of specific cytotoxic T lymphocytes and antibodies
    • Hoerr, I., Obst, R., Rammensee, H. and Jung, G. (2000) In vivo application of RNA leads to induction of specific cytotoxic T lymphocytes and antibodies. Eur J Immunol 30: 1–7
    • (2000) Eur J Immunol , vol.30 , pp. 1-7
    • Hoerr, I.1    Obst, R.2    Rammensee, H.3    Jung, G.4
  • 55
    • 33845497677 scopus 로고    scopus 로고
    • Modification of antigen-encoding RNA increases stability, translational efficacy, and T-cell stimulatory capacity of dendritic cells
    • Holtkamp, S., Kreiter, S., Selmi, A., Simon, P., Koslowski, M., Huber, C. et al. (2006) Modification of antigen-encoding RNA increases stability, translational efficacy, and T-cell stimulatory capacity of dendritic cells. Blood 108: 4009–4017
    • (2006) Blood , vol.108 , pp. 4009-4017
    • Holtkamp, S.1    Kreiter, S.2    Selmi, A.3    Simon, P.4    Koslowski, M.5    Huber, C.6
  • 56
    • 79955006476 scopus 로고    scopus 로고
    • A point mutation in the amino terminus of TLR7 abolishes signaling without affecting ligand binding
    • Iavarone, C., Ramsauer, K., Kubarenko, A., Debasitis, J., Leykin, I., Weber, A. et al. (2011) A point mutation in the amino terminus of TLR7 abolishes signaling without affecting ligand binding. J Immunol 186: 4213–4222
    • (2011) J Immunol , vol.186 , pp. 4213-4222
    • Iavarone, C.1    Ramsauer, K.2    Kubarenko, A.3    Debasitis, J.4    Leykin, I.5    Weber, A.6
  • 57
    • 0029045376 scopus 로고
    • A Sindbis virus mRNA polynucleotide vector achieves prolonged and high level heterologous gene expression in vivo
    • Johanning, F., Conry, R., LoBuglio, A., Wright, M., Sumerel, L., Pike, M. et al. (1995) A Sindbis virus mRNA polynucleotide vector achieves prolonged and high level heterologous gene expression in vivo. Nucleic Acids Res 23: 1495–1501
    • (1995) Nucleic Acids Res , vol.23 , pp. 1495-1501
    • Johanning, F.1    Conry, R.2    Lobuglio, A.3    Wright, M.4    Sumerel, L.5    Pike, M.6
  • 58
    • 84855383397 scopus 로고    scopus 로고
    • Intradermal electroporation of naked replicon RNA elicits strong immune responses
    • Johansson, D., Ljungberg, K., Kakoulidou, M. and Liljeström, P. (2012) Intradermal electroporation of naked replicon RNA elicits strong immune responses. PLoS One 7: e29732
    • (2012) Plos One , vol.7
    • Johansson, D.1    Ljungberg, K.2    Kakoulidou, M.3    Liljeström, P.4
  • 59
    • 0034955802 scopus 로고    scopus 로고
    • Molecular pathogenesis of influenza A virus infection and virus-induced regulation of cytokine gene expression
    • Julkunen, I., Sareneva, T., Pirhonen, J., Ronni, T., Melen, K. and Matikainen, S. (2001) Molecular pathogenesis of influenza A virus infection and virus-induced regulation of cytokine gene expression. Cytokine Growth Factor Rev 12: 171–180
    • (2001) Cytokine Growth Factor Rev , vol.12 , pp. 171-180
    • Julkunen, I.1    Sareneva, T.2    Pirhonen, J.3    Ronni, T.4    Melen, K.5    Matikainen, S.6
  • 61
    • 23844464444 scopus 로고    scopus 로고
    • Suppression of RNA recognition by Toll-like receptors: The impact of nucleoside modification and the evolutionary origin of RNA
    • Kariko, K., Buckstein, M., Ni, H. and Weissman, D. (2005) Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA. Immunity 23: 165–175
    • (2005) Immunity , vol.23 , pp. 165-175
    • Kariko, K.1    Buckstein, M.2    Ni, H.3    Weissman, D.4
  • 62
    • 84860539841 scopus 로고    scopus 로고
    • Increased erythropoiesis in mice injected with submicrogram quantities of pseudouridinecontaining mRNA encoding erythropoietin
    • Kariko, K., Muramatsu, H., Keller, J. and Weissman, D. (2012) Increased erythropoiesis in mice injected with submicrogram quantities of pseudouridinecontaining mRNA encoding erythropoietin. Mol Ther 20: 948–953
    • (2012) Mol Ther , vol.20 , pp. 948-953
    • Kariko, K.1    Muramatsu, H.2    Keller, J.3    Weissman, D.4
  • 63
    • 54949112814 scopus 로고    scopus 로고
    • Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability
    • Kariko, K., Muramatsu, H., Welsh, F., Ludwig, J., Kato, H., Akira, S. et al. (2008) Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability. Mol Ther 16: 1833–1840
    • (2008) Mol Ther , vol.16 , pp. 1833-1840
    • Kariko, K.1    Muramatsu, H.2    Welsh, F.3    Ludwig, J.4    Kato, H.5    Akira, S.6
  • 64
    • 34548431318 scopus 로고    scopus 로고
    • Naturally occurring nucleoside modifications suppress the immunostimulatory activity of RNA: Implication for therapeutic RNA development
    • Kariko, K. and Weissman, D. (2007) Naturally occurring nucleoside modifications suppress the immunostimulatory activity of RNA: implication for therapeutic RNA development. Curr Opin Drug Discov Devel 10: 523–532
    • (2007) Curr Opin Drug Discov Devel , vol.10 , pp. 523-532
    • Kariko, K.1    Weissman, D.2
  • 66
    • 84859007690 scopus 로고    scopus 로고
    • A novel therapeutic cytomegalovirus DNA vaccine in allogeneic haemopoietic stem-cell transplantation: A randomised, double-blind, placebo-controlled, phase 2 trial
    • Kharfan-Dabaja, M., Boeckh, M., Wilck, M., Langston, A., Chu, A., Wloch, M. et al. (2012) A novel therapeutic cytomegalovirus DNA vaccine in allogeneic haemopoietic stem-cell transplantation: a randomised, double-blind, placebo-controlled, phase 2 trial. Lancet Infect Dis 12: 290–299
    • (2012) Lancet Infect Dis , vol.12 , pp. 290-299
    • Kharfan-Dabaja, M.1    Boeckh, M.2    Wilck, M.3    Langston, A.4    Chu, A.5    Wloch, M.6
  • 67
    • 84876067164 scopus 로고    scopus 로고
    • TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal
    • Killela, P., Reitman, Z., Jiao, Y., Bettegowda, C., Agrawal, N., Diaz, L., Jr et al. (2013) TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal. Proc Natl Acad Sci U S A 110: 6021–6026
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 6021-6026
    • Killela, P.1    Reitman, Z.2    Jiao, Y.3    Bettegowda, C.4    Agrawal, N.5    Diaz, L.6
  • 68
    • 0037218553 scopus 로고    scopus 로고
    • Enhanced immunogenicity to Mycobacterium tuberculosis by vaccination with an alphavirus plasmid replicon expressing antigen 85A
    • Kirman, J., Turon, T., Su, H., Li, A., Kraus, C., Polo, J. et al. (2003) Enhanced immunogenicity to Mycobacterium tuberculosis by vaccination with an alphavirus plasmid replicon expressing antigen 85A. Infect Immun 71: 575–579
    • (2003) Infect Immun , vol.71 , pp. 575-579
    • Kirman, J.1    Turon, T.2    Su, H.3    Li, A.4    Kraus, C.5    Polo, J.6
  • 69
    • 79751497093 scopus 로고    scopus 로고
    • Expression of therapeutic proteins after delivery of chemically modified mRNA in mice
    • Kormann, M., Hasenpusch, G., Aneja, M., Nica, G., Flemmer, A., Herber-Jonat, S. et al. (2011) Expression of therapeutic proteins after delivery of chemically modified mRNA in mice. Nat Biotechnol 29: 154–157
    • (2011) Nat Biotechnol , vol.29 , pp. 154-157
    • Kormann, M.1    Hasenpusch, G.2    Aneja, M.3    Nica, G.4    Flemmer, A.5    Herber-Jonat, S.6
  • 70
    • 1642268316 scopus 로고    scopus 로고
    • Cutting edge: Innate immune system discriminates between RNA containing bacterial versus eukaryotic structural features that prime for high-level IL-12 secretion by dendritic cells
    • Koski, G., Kariko, K., Xu, S., Weissman, D., Cohen, P. and Czerniecki, B. (2004) Cutting edge: innate immune system discriminates between RNA containing bacterial versus eukaryotic structural features that prime for high-level IL-12 secretion by dendritic cells. J Immunol 172: 3989–3993
    • (2004) J Immunol , vol.172 , pp. 3989-3993
    • Koski, G.1    Kariko, K.2    Xu, S.3    Weissman, D.4    Cohen, P.5    Czerniecki, B.6
  • 71
    • 84883251918 scopus 로고    scopus 로고
    • Targeting the tumor mutanome for personalized vaccination therapy
    • Kreiter, S., Castle, J., Tureci, O. and Sahin, U. (2012) Targeting the tumor mutanome for personalized vaccination therapy. Oncoimmunology 1: 768–769
    • (2012) Oncoimmunology , vol.1 , pp. 768-769
    • Kreiter, S.1    Castle, J.2    Tureci, O.3    Sahin, U.4
  • 72
    • 79957732443 scopus 로고    scopus 로고
    • Tumor vaccination using messenger RNA: Prospects of a future therapy
    • Kreiter, S., Diken, M., Selmi, A., Tureci, O. and Sahin, U. (2011) Tumor vaccination using messenger RNA: prospects of a future therapy. Curr Opin Immunol 23: 399–406
    • (2011) Curr Opin Immunol , vol.23 , pp. 399-406
    • Kreiter, S.1    Diken, M.2    Selmi, A.3    Tureci, O.4    Sahin, U.5
  • 73
    • 78549283854 scopus 로고    scopus 로고
    • Intranodal vaccination with naked antigen-encoding RNA elicits potent prophylactic and therapeutic antitumoral immunity
    • Kreiter, S., Selmi, A., Diken, M., Koslowski, M., Britten, C., Huber, C. et al. (2010) Intranodal vaccination with naked antigen-encoding RNA elicits potent prophylactic and therapeutic antitumoral immunity. Cancer Res 70: 9031–9040
    • (2010) Cancer Res , vol.70 , pp. 9031-9040
    • Kreiter, S.1    Selmi, A.2    Diken, M.3    Koslowski, M.4    Britten, C.5    Huber, C.6
  • 74
    • 40449083962 scopus 로고    scopus 로고
    • Increased antigen presentation efficiency by coupling antigens to MHC class I trafficking signals
    • Kreiter, S., Selmi, A., Diken, M., Sebastian, M., Osterloh, P., Schild, H. et al. (2008) Increased antigen presentation efficiency by coupling antigens to MHC class I trafficking signals. J Immunol 180: 309–318
    • (2008) J Immunol , vol.180 , pp. 309-318
    • Kreiter, S.1    Selmi, A.2    Diken, M.3    Sebastian, M.4    Osterloh, P.5    Schild, H.6
  • 75
    • 84870924928 scopus 로고    scopus 로고
    • Final analysis of a phase I/IIa study with CV9103, an intradermally administered prostate cancer immunotherapy based on self-adjuvanted mRNA
    • Kübler, H., Maurer, T., Stenzl, A., Feyerabend, S., Steiner, U., Schostak, M. et al. (2011) Final analysis of a phase I/IIa study with CV9103, an intradermally administered prostate cancer immunotherapy based on self-adjuvanted mRNA. J Clin Oncol 29(Suppl.): abstract 4535
    • (2011) J Clin Oncol , vol.29
    • Kübler, H.1    Maurer, T.2    Stenzl, A.3    Feyerabend, S.4    Steiner, U.5    Schostak, M.6
  • 76
    • 77955658245 scopus 로고    scopus 로고
    • Phosphorothioate cap analogs increase stability and translational efficiency of RNA vaccines in immature dendritic cells and induce superior immune responses in vivo
    • Kuhn, A., Diken, M., Kreiter, S., Selmi, A., Kowalska, J., Jemielity, J. et al. (2010) Phosphorothioate cap analogs increase stability and translational efficiency of RNA vaccines in immature dendritic cells and induce superior immune responses in vivo. Gene Ther 17: 961–971
    • (2010) Gene Ther , vol.17 , pp. 961-971
    • Kuhn, A.1    Diken, M.2    Kreiter, S.3    Selmi, A.4    Kowalska, J.5    Jemielity, J.6
  • 77
    • 29044437033 scopus 로고    scopus 로고
    • Protective immunity and lack of histopathological damage two years after DNA vaccination against infectious hematopoietic necrosis virus in trout
    • Kurath, G., Garver, K., Corbeil, S., Elliott, D., Anderson, E. and LaPatra, S. (2006) Protective immunity and lack of histopathological damage two years after DNA vaccination against infectious hematopoietic necrosis virus in trout. Vaccine 24: 345–354
    • (2006) Vaccine , vol.24 , pp. 345-354
    • Kurath, G.1    Garver, K.2    Corbeil, S.3    Elliott, D.4    Erson, E.5    Lapatra, S.6
  • 78
    • 84868007347 scopus 로고    scopus 로고
    • Activation of innate immunity is required for efficient nuclear reprogramming
    • Lee, J., Sayed, N., Hunter, A., Au, K., Wong, W., Mocarski, E. et al. (2012) Activation of innate immunity is required for efficient nuclear reprogramming. Cell 151: 547–558
    • (2012) Cell , vol.151 , pp. 547-558
    • Lee, J.1    Sayed, N.2    Hunter, A.3    Au, K.4    Wong, W.5    Mocarski, E.6
  • 79
    • 0037236237 scopus 로고    scopus 로고
    • Alphavirusbased DNA vaccine breaks immunological tolerance by activating innate antiviral pathways
    • Leitner, W., Hwang, L., deVeer, M., Zhou, A., Silverman, R., Williams, B. et al. (2003) Alphavirusbased DNA vaccine breaks immunological tolerance by activating innate antiviral pathways. Nat Med 9: 33–39
    • (2003) Nat Med , vol.9 , pp. 33-39
    • Leitner, W.1    Hwang, L.2    Deveer, M.3    Zhou, A.4    Silverman, R.5    Williams, B.6
  • 80
    • 0033955167 scopus 로고    scopus 로고
    • Enhancement of tumor-specific immune response with plasmid DNA replicon vectors
    • Leitner, W., Ying, H., Driver, D., Dubensky, T. and Restifo, N. (2000) Enhancement of tumor-specific immune response with plasmid DNA replicon vectors. Cancer Res 60: 51–55
    • (2000) Cancer Res , vol.60 , pp. 51-55
    • Leitner, W.1    Ying, H.2    Driver, D.3    Dubensky, T.4    Restifo, N.5
  • 81
    • 84878487919 scopus 로고    scopus 로고
    • How do we optimally use cetuximab in first-line treatment for metastatic colorectal cancer?
    • Lindsay, C., Roxburgh, P. and Graham, J. (2013) How do we optimally use cetuximab in first-line treatment for metastatic colorectal cancer? Future Oncol 9: 825–829
    • (2013) Future Oncol , vol.9 , pp. 825-829
    • Lindsay, C.1    Roxburgh, P.2    Graham, J.3
  • 82
    • 84869211465 scopus 로고    scopus 로고
    • Hemophilia and prophylaxis
    • Ljung, R. (2013) Hemophilia and prophylaxis. Pediatr Blood Cancer 60(Suppl. 1): S23–S26
    • (2013) Pediatr Blood Cancer , vol.60
    • Ljung, R.1
  • 83
    • 79960107932 scopus 로고    scopus 로고
    • Protein expression from exogenous mRNA: Uptake by receptor-mediated endocytosis and trafficking via the lysosomal pathway
    • Lorenz, C., Fotin-Mleczek, M., Roth, G., Becker, C., Dam, T., Verdurmen, W. et al. (2011) Protein expression from exogenous mRNA: uptake by receptor-mediated endocytosis and trafficking via the lysosomal pathway. RNA Biol 8: 627–636
    • (2011) RNA Biol , vol.8 , pp. 627-636
    • Lorenz, C.1    Fotin-Mleczek, M.2    Roth, G.3    Becker, C.4    Dam, T.5    Verdurmen, W.6
  • 84
    • 84861178107 scopus 로고    scopus 로고
    • Clinical evaluation of TRICOM vector therapeutic cancer vaccines
    • Madan, R., Bilusic, M., Heery, C., Schlom, J. and Gulley, J. (2012) Clinical evaluation of TRICOM vector therapeutic cancer vaccines. Semin Oncol 39: 296–304
    • (2012) Semin Oncol , vol.39 , pp. 296-304
    • Madan, R.1    Bilusic, M.2    Heery, C.3    Schlom, J.4    Gulley, J.5
  • 85
    • 84875160871 scopus 로고    scopus 로고
    • Reprogramming human fibroblasts to pluripotency using modified mRNA
    • Mandal, P. and Rossi, D. (2013) Reprogramming human fibroblasts to pluripotency using modified mRNA. Nat Protoc 8: 568–582
    • (2013) Nat Protoc , vol.8 , pp. 568-582
    • Mandal, P.1    Rossi, D.2
  • 86
    • 79961167250 scopus 로고    scopus 로고
    • DNA released from dying host cells mediates aluminum adjuvant activity
    • Marichal, T., Ohata, K., Bedoret, D., Mesnil, C., Sabatel, C., Kobiyama, K. et al. (2011) DNA released from dying host cells mediates aluminum adjuvant activity. Nat Med 17: 996–1002
    • (2011) Nat Med , vol.17 , pp. 996-1002
    • Marichal, T.1    Ohata, K.2    Bedoret, D.3    Mesnil, C.4    Sabatel, C.5    Kobiyama, K.6
  • 87
    • 0027170483 scopus 로고
    • Induction of virus-specific cytotoxic T lymphocytes in vivo by liposome-entrapped mRNA
    • Martinon, F., Krishnan, S., Lenzen, G., Magne, R., Gomard, E., Guillet, J. et al. (1993) Induction of virus-specific cytotoxic T lymphocytes in vivo by liposome-entrapped mRNA. Eur J Immunol 23: 1719–1722
    • (1993) Eur J Immunol , vol.23 , pp. 1719-1722
    • Martinon, F.1    Krishnan, S.2    Lenzen, G.3    Magne, R.4    Gomard, E.5    Guillet, J.6
  • 89
    • 84870328782 scopus 로고    scopus 로고
    • The efficacy of biologic agents in patients with rheumatoid arthritis and an inadequate response to tumour necrosis factor inhibitors: A systematic review
    • Moots, R. and Naisbett-Groet, B. (2012) The efficacy of biologic agents in patients with rheumatoid arthritis and an inadequate response to tumour necrosis factor inhibitors: a systematic review. Rheumatology (Oxford) 51: 2252–2261
    • (2012) Rheumatology (Oxford) , vol.51 , pp. 2252-2261
    • Moots, R.1    Naisbett-Groet, B.2
  • 90
    • 77956372182 scopus 로고    scopus 로고
    • An alphavirus vector overcomes the presence of neutralizing antibodies and elevated numbers of Tregs to induce immune responses in humans with advanced cancer
    • Morse, M., Hobeika, A., Osada, T., Berglund, P., Hubby, B., Negri, S. et al. (2010) An alphavirus vector overcomes the presence of neutralizing antibodies and elevated numbers of Tregs to induce immune responses in humans with advanced cancer. J Clin Invest 120: 3234–3241
    • (2010) J Clin Invest , vol.120 , pp. 3234-3241
    • Morse, M.1    Hobeika, A.2    Osada, T.3    Berglund, P.4    Hubby, B.5    Negri, S.6
  • 91
    • 33744473294 scopus 로고    scopus 로고
    • Intrasplenic steady-state dendritic cell precursors that are distinct from monocytes
    • Naik, S., Metcalf, D., van Nieuwenhuijze, A., Wicks, I., Wu, L., O’Keeffe, M. et al. (2006) Intrasplenic steady-state dendritic cell precursors that are distinct from monocytes. Nat Immunol 7: 663–671
    • (2006) Nat Immunol , vol.7 , pp. 663-671
    • Naik, S.1    Metcalf, D.2    Van Nieuwenhuijze, A.3    Wicks, I.4    Wu, L.5    O’Keeffe, M.6
  • 92
    • 84939472843 scopus 로고    scopus 로고
    • Phase IB study on combined intradermal (ID) and intravenous (IV) administration of autologous mRNA electroporated dendritic cells (DC) as a singleagent cellular immunotherapy or combined with ipilimumab
    • Neyns, B., Wilgenhof, S., Van Nuffel, A., Benteyn, D. and Corthals, J., Heirman, C. et al. (2012) Phase IB study on combined intradermal (ID) and intravenous (IV) administration of autologous mRNA electroporated dendritic cells (DC) as a singleagent cellular immunotherapy or combined with ipilimumab. J Clin Oncol 30(Suppl.): abstract 2507
    • (2012) J Clin Oncol , vol.30
    • Neyns, B.1    Wilgenhof, S.2    Van Nuffel, A.3    Benteyn, D.4    Corthals, J.5    Heirman, C.6
  • 93
    • 4944223122 scopus 로고    scopus 로고
    • Manipulating dendritic cell biology for the active immunotherapy of cancer
    • O’Neill, D., Adams, S. and Bhardwaj, N. (2004) Manipulating dendritic cell biology for the active immunotherapy of cancer. Blood 104: 2235–2246
    • (2004) Blood , vol.104 , pp. 2235-2246
    • O’Neill, D.1    Adams, S.2    Bhardwaj, N.3
  • 94
    • 21844450539 scopus 로고    scopus 로고
    • Antigenengaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells
    • Okada, T., Miller, M., Parker, I., Krummel, M., Neighbors, M., Hartley, S. et al. (2005) Antigenengaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells. PLoS Biol 3: e150
    • (2005) Plos Biol , vol.3
    • Okada, T.1    Miller, M.2    Parker, I.3    Krummel, M.4    Neighbors, M.5    Hartley, S.6
  • 96
    • 3442896311 scopus 로고    scopus 로고
    • Messenger RNA-based vaccines
    • Pascolo, S. (2004) Messenger RNA-based vaccines. Expert Opin Biol Ther 4: 1285–1294
    • (2004) Expert Opin Biol Ther , vol.4 , pp. 1285-1294
    • Pascolo, S.1
  • 97
    • 33750110852 scopus 로고    scopus 로고
    • Vaccination with messenger RNA
    • Pascolo, S. (2006) Vaccination with messenger RNA. Methods Mol Med 127: 23–40
    • (2006) Methods Mol Med , vol.127 , pp. 23-40
    • Pascolo, S.1
  • 98
    • 84870869040 scopus 로고    scopus 로고
    • Protective efficacy of in vitro synthesized, specific mRNA vaccines against influenza A virus infection
    • Petsch, B., Schnee, M., Vogel, A., Lange, E., Hoffmann, B., Voss, D. et al. (2012) Protective efficacy of in vitro synthesized, specific mRNA vaccines against influenza A virus infection. Nat Biotechnol 30: 1210–1216
    • (2012) Nat Biotechnol , vol.30 , pp. 1210-1216
    • Petsch, B.1    Schnee, M.2    Vogel, A.3    Lange, E.4    Hoffmann, B.5    Voss, D.6
  • 99
    • 33750984771 scopus 로고    scopus 로고
    • RIG-Imediated antiviral responses to single-stranded RNA bearing 5’-phosphates
    • Pichlmair, A., Schulz, O., Tan, C., Naslund, T., Liljeström, P., Weber, F. et al. (2006) RIG-Imediated antiviral responses to single-stranded RNA bearing 5’-phosphates. Science 314: 997–1001
    • (2006) Science , vol.314 , pp. 997-1001
    • Pichlmair, A.1    Schulz, O.2    Tan, C.3    Naslund, T.4    Liljeström, P.5    Weber, F.6
  • 100
    • 84871926389 scopus 로고    scopus 로고
    • Type I IFN counteracts the induction of antigen-specific immune responses by lipid-based delivery of mRNA vaccines
    • Pollard, C., Rejman, J., De Haes, W., Verrier, B., Van Gulck, E., Naessens, T. et al. (2013) Type I IFN counteracts the induction of antigen-specific immune responses by lipid-based delivery of mRNA vaccines. Mol Ther 21: 251–259
    • (2013) Mol Ther , vol.21 , pp. 251-259
    • Pollard, C.1    Rejman, J.2    De Haes, W.3    Verrier, B.4    Van Gulck, E.5    Naessens, T.6
  • 101
    • 84875880394 scopus 로고    scopus 로고
    • Considerations for early switch to nilotinib or dasatinib in patients with chronic myeloid leukemia with inadequate response to first-line imatinib
    • Quintas-Cardama, A. and Jabbour, E. (2013) Considerations for early switch to nilotinib or dasatinib in patients with chronic myeloid leukemia with inadequate response to first-line imatinib. Leuk Res 37: 487–495
    • (2013) Leuk Res , vol.37 , pp. 487-495
    • Quintas-Cardama, A.1    Jabbour, E.2
  • 102
    • 75749140581 scopus 로고    scopus 로고
    • RIG-I detects viral genomic RNA during negative-strand RNA virus infection
    • Rehwinkel, J., Tan, C., Goubau, D., Schulz, O., Pichlmair, A., Bier, K. et al. (2010) RIG-I detects viral genomic RNA during negative-strand RNA virus infection. Cell 140: 397–408
    • (2010) Cell , vol.140 , pp. 397-408
    • Rehwinkel, J.1    Tan, C.2    Goubau, D.3    Schulz, O.4    Pichlmair, A.5    Bier, K.6
  • 103
    • 79955630363 scopus 로고    scopus 로고
    • Intradermal vaccinations with RNA coding for TAA generate CD8+ and CD4+ immune responses and induce clinical benefit in vaccinated patients
    • Rittig, S., Haentschel, M., Weimer, K., Heine, A., Muller, M., Brugger, W. et al. (2011) Intradermal vaccinations with RNA coding for TAA generate CD8+ and CD4+ immune responses and induce clinical benefit in vaccinated patients. Mol Ther 19: 990–999
    • (2011) Mol Ther , vol.19 , pp. 990-999
    • Rittig, S.1    Haentschel, M.2    Weimer, K.3    Heine, A.4    Muller, M.5    Brugger, W.6
  • 104
    • 84858664440 scopus 로고    scopus 로고
    • Rituximab for chronic lymphocytic leukemia
    • Robak, T. (2012) Rituximab for chronic lymphocytic leukemia. Expert Opin Biol Ther 12: 503–515
    • (2012) Expert Opin Biol Ther , vol.12 , pp. 503-515
    • Robak, T.1
  • 106
    • 79957590694 scopus 로고    scopus 로고
    • Small molecule toll-like receptor 7 agonists localize to the MHC class II loading compartment of human plasmacytoid dendritic cells
    • Russo, C., Cornella-Taracido, I., Galli-Stampino, L., Jain, R., Harrington, E., Isome, Y. et al. (2011) Small molecule toll-like receptor 7 agonists localize to the MHC class II loading compartment of human plasmacytoid dendritic cells. Blood 117: 5683–5691
    • (2011) Blood , vol.117 , pp. 5683-5691
    • Russo, C.1    Cornella-Taracido, I.2    Galli-Stampino, L.3    Jain, R.4    Harrington, E.5    Isome, Y.6
  • 107
    • 79957781340 scopus 로고    scopus 로고
    • Electroporation delivery of DNA vaccines: Prospects for success
    • Sardesai, N. and Weiner, D. (2011) Electroporation delivery of DNA vaccines: prospects for success. Curr Opin Immunol 23: 421–429
    • (2011) Curr Opin Immunol , vol.23 , pp. 421-429
    • Sardesai, N.1    Weiner, D.2
  • 108
    • 33645325115 scopus 로고    scopus 로고
    • Dacarbazine (DTIC) versus vaccination with autologous peptide-pulsed dendritic cells (DC) in first-line treatment of patients with metastatic melanoma: A randomized phase III trial of the DC study group of the DeCOG
    • Schadendorf, D., Ugurel, S., Schuler-Thurner, B., Nestle, F., Enk, A., Brocker, E. et al. (2006) Dacarbazine (DTIC) versus vaccination with autologous peptide-pulsed dendritic cells (DC) in first-line treatment of patients with metastatic melanoma: a randomized phase III trial of the DC study group of the DeCOG. Ann Oncol 17: 563–570
    • (2006) Ann Oncol , vol.17 , pp. 563-570
    • Schadendorf, D.1    Ugurel, S.2    Schuler-Thurner, B.3    Nestle, F.4    Enk, A.5    Brocker, E.6
  • 109
    • 21044440406 scopus 로고    scopus 로고
    • Toll-like receptordependent activation of several human blood cell types by protamine-condensed mRNA
    • Scheel, B., Teufel, R., Probst, J., Carralot, J., Geginat, J., Radsak, M. et al. (2005) Toll-like receptordependent activation of several human blood cell types by protamine-condensed mRNA. Eur J Immunol 35: 1557–1566
    • (2005) Eur J Immunol , vol.35 , pp. 1557-1566
    • Scheel, B.1    Teufel, R.2    Probst, J.3    Carralot, J.4    Geginat, J.5    Radsak, M.6
  • 110
    • 33745126286 scopus 로고    scopus 로고
    • Inhibition of type I allergic responses with nanogram doses of repliconbased DNA vaccines
    • Scheiblhofer, S., Gabler, M., Leitner, W., Bauer, R., Zoegg, T., Ferreira, F. et al. (2006a) Inhibition of type I allergic responses with nanogram doses of repliconbased DNA vaccines. Allergy 61: 828–835
    • (2006) Allergy , vol.61 , pp. 828-835
    • Scheiblhofer, S.1    Gabler, M.2    Leitner, W.3    Bauer, R.4    Zoegg, T.5    Ferreira, F.6
  • 111
    • 84878095825 scopus 로고    scopus 로고
    • Laser microporation of the skin: Prospects for painless application of protective and therapeutic vaccines
    • Scheiblhofer, S., Thalhamer, J. and Weiss, R. (2013) Laser microporation of the skin: prospects for painless application of protective and therapeutic vaccines. Expert Opin Drug Deliv 10: 761–773
    • (2013) Expert Opin Drug Deliv , vol.10 , pp. 761-773
    • Scheiblhofer, S.1    Thalhamer, J.2    Weiss, R.3
  • 114
    • 20044382430 scopus 로고    scopus 로고
    • Toll-like receptor 3 promotes cross-priming to virus-infected cells
    • Schulz, O., Diebold, S., Chen, M., Naslund, T., Nolte, M., Alexopoulou, L. et al. (2005) Toll-like receptor 3 promotes cross-priming to virus-infected cells. Nature 433: 887–892
    • (2005) Nature , vol.433 , pp. 887-892
    • Schulz, O.1    Diebold, S.2    Chen, M.3    Naslund, T.4    Nolte, M.5    Alexopoulou, L.6
  • 117
    • 84883245346 scopus 로고    scopus 로고
    • CCL19, a B-cell chemokine, is related to the decrease of blood memory B-cells and predicts the clinical response to rituximab in rheumatoid arthritis
    • Sellam, J., Rouanet, S., Hendel-Chavez, H., Miceli- Richard, C., Combe, B., Sibilia, J. et al. (2013) CCL19, a B-cell chemokine, is related to the decrease of blood memory B-cells and predicts the clinical response to rituximab in rheumatoid arthritis. Arthritis Rheum 65: 2253–2261
    • (2013) Arthritis Rheum , vol.65 , pp. 2253-2261
    • Sellam, J.1    Rouanet, S.2    Hendel-Chavez, H.3    Miceli- Richard, C.4    Combe, B.5    Sibilia, J.6
  • 118
    • 34548050436 scopus 로고    scopus 로고
    • CD8 T cell dysfunction during chronic viral infection
    • Shin, H. and Wherry, E. (2007) CD8 T cell dysfunction during chronic viral infection. Curr Opin Immunol 19: 408–415
    • (2007) Curr Opin Immunol , vol.19 , pp. 408-415
    • Shin, H.1    Wherry, E.2
  • 119
    • 84872618287 scopus 로고    scopus 로고
    • A phase I dose escalation trial of vaccine replicon particles (VRP) expressing prostatespecific membrane antigen (PSMA) in subjects with prostate cancer
    • Slovin, S., Kehoe, M., Durso, R., Fernandez, C., Olson, W., Gao, J. et al. (2013) A phase I dose escalation trial of vaccine replicon particles (VRP) expressing prostatespecific membrane antigen (PSMA) in subjects with prostate cancer. Vaccine 31: 943–949
    • (2013) Vaccine , vol.31 , pp. 943-949
    • Slovin, S.1    Kehoe, M.2    Durso, R.3    Fernandez, C.4    Olson, W.5    Gao, J.6
  • 120
    • 84876232194 scopus 로고    scopus 로고
    • Cetuximab: Its unique place in head and neck cancer treatment
    • Specenier, P. and Vermorken, J. (2013) Cetuximab: its unique place in head and neck cancer treatment. Biologics 7: 77–90
    • (2013) Biologics , vol.7 , pp. 77-90
    • Specenier, P.1    Vermorken, J.2
  • 121
    • 84857304221 scopus 로고    scopus 로고
    • NOD/scid IL-2Rg(Null) mice: A preclinical model system to evaluate human dendritic cell-based vaccine strategies in vivo
    • Spranger, S., Frankenberger, B. and Schendel, D. (2012) NOD/scid IL-2Rg(null) mice: a preclinical model system to evaluate human dendritic cell-based vaccine strategies in vivo. J Transl Med 10: 30
    • (2012) J Transl Med , vol.10
    • Spranger, S.1    Frankenberger, B.2    Schendel, D.3
  • 122
    • 77956222584 scopus 로고    scopus 로고
    • Generation of Th1-polarizing dendritic cells using the TLR7/8 agonist CL075
    • Spranger, S., Javorovic, M., Burdek, M., Wilde, S., Mosetter, B., Tippmer, S. et al. (2010) Generation of Th1-polarizing dendritic cells using the TLR7/8 agonist CL075. J Immunol 185: 738–747
    • (2010) J Immunol , vol.185 , pp. 738-747
    • Spranger, S.1    Javorovic, M.2    Burdek, M.3    Wilde, S.4    Mosetter, B.5    Tippmer, S.6
  • 123
    • 0037062920 scopus 로고    scopus 로고
    • Emerging clinical applications of RNA
    • Sullenger, B. and Gilboa, E. (2002) Emerging clinical applications of RNA. Nature 418: 252–258
    • (2002) Nature , vol.418 , pp. 252-258
    • Sullenger, B.1    Gilboa, E.2
  • 124
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K. et al. (2007) Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131: 861–872
    • (2007) Cell , vol.131 , pp. 861-872
    • Takahashi, K.1    Tanabe, K.2    Ohnuki, M.3    Narita, M.4    Ichisaka, T.5    Tomoda, K.6
  • 125
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi, K. and Yamanaka, S. (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126: 663–676
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 127
    • 0026579897 scopus 로고
    • Genetic immunization is a simple method for eliciting an immune response
    • Tang, D., DeVit, M. and Johnston, S. (1992) Genetic immunization is a simple method for eliciting an immune response. Nature 356: 152–154
    • (1992) Nature , vol.356 , pp. 152-154
    • Tang, D.1    Devit, M.2    Johnston, S.3
  • 128
    • 77950205047 scopus 로고    scopus 로고
    • Designing hypoallergenic derivatives for allergy treatment by means of in silico mutation and screening
    • Thalhamer, T., Dobias, H., Stepanoska, T., Proll, M., Stutz, H., Dissertori, O. et al. (2010) Designing hypoallergenic derivatives for allergy treatment by means of in silico mutation and screening. J Allergy Clin Immunol 125: 926–934 e910
    • (2010) J Allergy Clin Immunol , vol.125
    • Thalhamer, T.1    Dobias, H.2    Stepanoska, T.3    Proll, M.4    Stutz, H.5    Dissertori, O.6
  • 129
    • 0027411456 scopus 로고
    • Heterologous protection against influenza by injection of DNA encoding a viral protein
    • Ulmer, J., Donnelly, J., Parker, S., Rhodes, G., Felgner, P., Dwarki, V. et al. (1993) Heterologous protection against influenza by injection of DNA encoding a viral protein. Science 259: 1745–1749
    • (1993) Science , vol.259 , pp. 1745-1749
    • Ulmer, J.1    Donnelly, J.2    Parker, S.3    Rhodes, G.4    Felgner, P.5    Dwarki, V.6
  • 131
    • 47749129289 scopus 로고    scopus 로고
    • Improved induction of antibodies against key neutralizing epitopes by human immunodeficiency virus type 1 gp120 DNA prime-protein boost vaccination compared to gp120 protein-only vaccination
    • Vaine, M., Wang, S., Crooks, E., Jiang, P., Montefiori, D., Binley, J. et al. (2008) Improved induction of antibodies against key neutralizing epitopes by human immunodeficiency virus type 1 gp120 DNA prime-protein boost vaccination compared to gp120 protein-only vaccination. J Virol 82: 7369–7378
    • (2008) J Virol , vol.82 , pp. 7369-7378
    • Vaine, M.1    Wang, S.2    Crooks, E.3    Jiang, P.4    Montefiori, D.5    Binley, J.6
  • 132
    • 33748686759 scopus 로고    scopus 로고
    • Simultaneous activation of viral antigen-specific memory CD4+ and CD8+ T-cells using mRNAelectroporated CD40-activated autologous B-cells
    • Van den Bosch, G., Van Gulck, E., Ponsaerts, P., Nijs, G., Lenjou, M., Apers, L. et al. (2006) Simultaneous activation of viral antigen-specific memory CD4+ and CD8+ T-cells using mRNAelectroporated CD40-activated autologous B-cells. J Immunother 29: 512–523
    • (2006) J Immunother , vol.29 , pp. 512-523
    • Van Den Bosch, G.1    Van Gulck, E.2    Ponsaerts, P.3    Nijs, G.4    Lenjou, M.5    Apers, L.6
  • 133
    • 84857045791 scopus 로고    scopus 로고
    • MRNA-based dendritic cell vaccination induces potent antiviral T-cell responses in HIV-1- infected patients
    • Van Gulck, E., Vlieghe, E., Vekemans, M., Van Tendeloo, V., Van De Velde, A., Smits, E. et al. (2012) mRNA-based dendritic cell vaccination induces potent antiviral T-cell responses in HIV-1- infected patients. AIDS 26: F1–F12
    • (2012) AIDS , vol.26
    • Van Gulck, E.1    Vlieghe, E.2    Vekemans, M.3    Van Tendeloo, V.4    Van De Velde, A.5    Smits, E.6
  • 134
    • 84865830845 scopus 로고    scopus 로고
    • Can immunotherapy be useful as a ’functional cure‘ for infection with human immunodeficiency virus-1?
    • Vanham, G. and Van Gulck, E. (2012) Can immunotherapy be useful as a ’functional cure‘ for infection with human immunodeficiency virus-1? Retrovirology 9: 72
    • (2012) Retrovirology , vol.9
    • Vanham, G.1    Van Gulck, E.2
  • 135
    • 84859417996 scopus 로고    scopus 로고
    • Preclinical evaluation of TriMix and antigen mRNA-based antitumor therapy
    • Van Lint, S., Goyvaerts, C., Maenhout, S., Goethals, L., Disy, A., Benteyn, D. et al. (2012) Preclinical evaluation of TriMix and antigen mRNA-based antitumor therapy. Cancer Res 72: 1661–1671
    • (2012) Cancer Res , vol.72 , pp. 1661-1671
    • Van Lint, S.1    Goyvaerts, C.2    Maenhout, S.3    Goethals, L.4    Disy, A.5    Benteyn, D.6
  • 136
    • 84874724470 scopus 로고    scopus 로고
    • MRNA: From a chemical blueprint for protein production to an off-the-shelf therapeutic
    • Van Lint, S., Heirman, C., Thielemans, K. and Breckpot, K. (2013) mRNA: From a chemical blueprint for protein production to an off-the-shelf therapeutic. Hum Vaccin Immunother 9: 265–274
    • (2013) Hum Vaccin Immunother , vol.9 , pp. 265-274
    • Van Lint, S.1    Heirman, C.2    Thielemans, K.3    Breckpot, K.4
  • 137
    • 84862772889 scopus 로고    scopus 로고
    • Intravenous and intradermal TriMix-dendritic cell therapy results in a broad T-cell response and durable tumor response in a chemorefractory stage IV-M1c melanoma patient
    • Van Nuffel, A., Benteyn, D., Wilgenhof, S., Corthals, J., Heirman, C., Neyns, B. et al. (2012a) Intravenous and intradermal TriMix-dendritic cell therapy results in a broad T-cell response and durable tumor response in a chemorefractory stage IV-M1c melanoma patient. Cancer Immunol Immunother 61: 1033–1043
    • (2012) Cancer Immunol Immunother , vol.61 , pp. 1033-1043
    • Van Nuffel, A.1    Benteyn, D.2    Wilgenhof, S.3    Corthals, J.4    Heirman, C.5    Neyns, B.6
  • 138
    • 84860521660 scopus 로고    scopus 로고
    • Dendritic cells loaded with mRNA encoding full-length tumor antigens prime CD4+ and CD8+ T cells in melanoma patients
    • Van Nuffel, A., Benteyn, D., Wilgenhof, S., Pierret, L., Corthals, J., Heirman, C. et al. (2012b) Dendritic cells loaded with mRNA encoding full-length tumor antigens prime CD4+ and CD8+ T cells in melanoma patients. Mol Ther 20: 1063–1074
    • (2012) Mol Ther , vol.20 , pp. 1063-1074
    • Van Nuffel, A.1    Benteyn, D.2    Wilgenhof, S.3    Pierret, L.4    Corthals, J.5    Heirman, C.6
  • 139
    • 84886943603 scopus 로고    scopus 로고
    • Overcoming HLA restriction in clinical trials: Immune monitoring of mRNA-loaded DC therapy
    • Van Nuffel, A., Wilgenhof, S., Thielemans, K. and Bonehill, A. (2012c) Overcoming HLA restriction in clinical trials: Immune monitoring of mRNA-loaded DC therapy. Oncoimmunology 1: 1392–1394
    • (2012) Oncoimmunology , vol.1 , pp. 1392-1394
    • Van Nuffel, A.1    Wilgenhof, S.2    Thielemans, K.3    Bonehill, A.4
  • 142
    • 84862291971 scopus 로고    scopus 로고
    • Toll-like receptor 7 is required for effective adaptive immune responses that prevent persistent virus infection
    • Walsh, K., Teijaro, J., Zuniga, E., Welch, M., Fremgen, D., Blackburn, S. et al. (2012) Toll-like receptor 7 is required for effective adaptive immune responses that prevent persistent virus infection. Cell Host Microbe 11: 643–653
    • (2012) Cell Host Microbe , vol.11 , pp. 643-653
    • Walsh, K.1    Teijaro, J.2    Zuniga, E.3    Welch, M.4    Fremgen, D.5    Blackburn, S.6
  • 143
    • 84864662070 scopus 로고    scopus 로고
    • Multipeptide immune response to cancer vaccine IMA901 after single-dose cyclophosphamide associates with longer patient survival
    • Walter, S., Weinschenk, T., Stenzl, A., Zdrojowy, R., Pluzanska, A., Szczylik, C. et al. (2012) Multipeptide immune response to cancer vaccine IMA901 after single-dose cyclophosphamide associates with longer patient survival. Nat Med 18: 1254–1261
    • (2012) Nat Med , vol.18 , pp. 1254-1261
    • Walter, S.1    Weinschenk, T.2    Stenzl, A.3    Zdrojowy, R.4    Pluzanska, A.5    Szczylik, C.6
  • 144
    • 84869802293 scopus 로고    scopus 로고
    • Pilot study on the immunogenicity of paired Env immunogens from mother-to-child transmitted HIV-1 isolates
    • Wang, S., Kishko, M., Wan, S., Wang, Y., Brewster, F., Gray, G. et al. (2012) Pilot study on the immunogenicity of paired Env immunogens from mother-to-child transmitted HIV-1 isolates. Hum Vaccin Immunother 8: 1638–1647
    • (2012) Hum Vaccin Immunother , vol.8 , pp. 1638-1647
    • Wang, S.1    Kishko, M.2    Wan, S.3    Wang, Y.4    Brewster, F.5    Gray, G.6
  • 145
    • 77958536106 scopus 로고    scopus 로고
    • Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA
    • Warren, L., Manos, P., Ahfeldt, T., Loh, Y., Li, H., Lau, F. et al. (2010) Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell 7: 618–630
    • (2010) Cell Stem Cell , vol.7 , pp. 618-630
    • Warren, L.1    Manos, P.2    Ahfeldt, T.3    Loh, Y.4    Li, H.5    Lau, F.6
  • 146
    • 44949195901 scopus 로고    scopus 로고
    • Results of the first phase I/II clinical vaccination trial with direct injection of mRNA
    • Weide, B., Carralot, J., Reese, A., Scheel, B., Eigentler, T., Hoerr, I. et al. (2008) Results of the first phase I/II clinical vaccination trial with direct injection of mRNA. J Immunother 31: 180–188
    • (2008) J Immunother , vol.31 , pp. 180-188
    • Weide, B.1    Carralot, J.2    Reese, A.3    Scheel, B.4    Eigentler, T.5    Hoerr, I.6
  • 147
    • 67651152679 scopus 로고    scopus 로고
    • Direct injection of protamine-protected mRNA: Results of a phase 1/2 vaccination trial in metastatic melanoma patients
    • Weide, B., Pascolo, S., Scheel, B., Derhovanessian, E., Pflugfelder, A., Eigentler, T. et al. (2009) Direct injection of protamine-protected mRNA: results of a phase 1/2 vaccination trial in metastatic melanoma patients. J Immunother 32: 498–507
    • (2009) J Immunother , vol.32 , pp. 498-507
    • Weide, B.1    Pascolo, S.2    Scheel, B.3    Derhovanessian, E.4    Pflugfelder, A.5    Eigentler, T.6
  • 150
    • 0037383592 scopus 로고    scopus 로고
    • Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment
    • Wherry, E., Blattman, J., Murali-Krishna, K., van der Most, R. and Ahmed, R. (2003) Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment. J Virol 77: 4911–4927
    • (2003) J Virol , vol.77 , pp. 4911-4927
    • Wherry, E.1    Blattman, J.2    Murali-Krishna, K.3    Van Der Most, R.4    Ahmed, R.5
  • 151
    • 0025338173 scopus 로고
    • How the messenger got its tail: Addition of poly(A) in the nucleus
    • Wickens, M. (1990) How the messenger got its tail: addition of poly(A) in the nucleus. Trends Biochem Sci 15: 277–281
    • (1990) Trends Biochem Sci , vol.15 , pp. 277-281
    • Wickens, M.1
  • 152
    • 79952984337 scopus 로고    scopus 로고
    • Restoration of tumor equilibrium after immunotherapy for advanced melanoma: Three illustrative cases
    • Wilgenhof, S., Pierret, L., Corthals, J., Van Nuffel, A., Heirman, C., Roelandt, T. et al. (2011a) Restoration of tumor equilibrium after immunotherapy for advanced melanoma: three illustrative cases. Melanoma Res 21: 152–159
    • (2011) Melanoma Res , vol.21 , pp. 152-159
    • Wilgenhof, S.1    Pierret, L.2    Corthals, J.3    Van Nuffel, A.4    Heirman, C.5    Roelandt, T.6
  • 153
    • 79957904174 scopus 로고    scopus 로고
    • Therapeutic vaccination with an autologous mRNA electroporated dendritic cell vaccine in patients with advanced melanoma
    • Wilgenhof, S., Van Nuffel, A., Corthals, J., Heirman, C., Tuyaerts, S., Benteyn, D. et al. (2011b) Therapeutic vaccination with an autologous mRNA electroporated dendritic cell vaccine in patients with advanced melanoma. J Immunother 34: 448–456
    • (2011) J Immunother , vol.34 , pp. 448-456
    • Wilgenhof, S.1    Van Nuffel, A.2    Corthals, J.3    Heirman, C.4    Tuyaerts, S.5    Benteyn, D.6
  • 154
    • 84884721824 scopus 로고    scopus 로고
    • Phase IB study on intravenous synthetic mRNA electroporated dendritic cell immunotherapy in pretreated advanced melanoma patients
    • Wilgenhof, S., Van Nuffel, A., Benteyn, D., Corthals, J., Aerts, C., Heirman, C. et al. (2013) Phase IB study on intravenous synthetic mRNA electroporated dendritic cell immunotherapy in pretreated advanced melanoma patients. Ann Oncol 24: 2686–2693
    • (2013) Ann Oncol , vol.24 , pp. 2686-2693
    • Wilgenhof, S.1    Van Nuffel, A.2    Benteyn, D.3    Corthals, J.4    Aerts, C.5    Heirman, C.6
  • 156
    • 18744409038 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells: A new cutaneous dendritic cell subset with distinct role in inflammatory skin diseases
    • Wollenberg, A., Wagner, M., Gunther, S., Towarowski, A., Tuma, E., Moderer, M. et al. (2002) Plasmacytoid dendritic cells: a new cutaneous dendritic cell subset with distinct role in inflammatory skin diseases. J Invest Dermatol 119: 1096–1102
    • (2002) J Invest Dermatol , vol.119 , pp. 1096-1102
    • Wollenberg, A.1    Wagner, M.2    Gunther, S.3    Towarowski, A.4    Tuma, E.5    Moderer, M.6
  • 157
    • 0024514346 scopus 로고
    • Sindbis virus: An efficient, broad host range vector for gene expression in animal cells
    • Xiong, C., Levis, R., Shen, P., Schlesinger, S., Rice, C. and Huang, H. (1989) Sindbis virus: an efficient, broad host range vector for gene expression in animal cells. Science 243: 1188–1191
    • (1989) Science , vol.243 , pp. 1188-1191
    • Xiong, C.1    Levis, R.2    Shen, P.3    Schlesinger, S.4    Rice, C.5    Huang, H.6
  • 158
    • 77949793550 scopus 로고    scopus 로고
    • Reprogramming of human fibroblasts to pluripotent stem cells using mRNA of four transcription factors
    • Yakubov, E., Rechavi, G., Rozenblatt, S. and Givol, D. (2010) Reprogramming of human fibroblasts to pluripotent stem cells using mRNA of four transcription factors. Biochem Biophys Res Commun 394: 189–193
    • (2010) Biochem Biophys Res Commun , vol.394 , pp. 189-193
    • Yakubov, E.1    Rechavi, G.2    Rozenblatt, S.3    Givol, D.4
  • 160
    • 84885676364 scopus 로고    scopus 로고
    • Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction
    • 8 September, Epub ahead of print
    • Zangi, L., Lui, K., von Gise, A., Ma, Q., Ebina, W., Ptaszek, L. et al. (2013) Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction. Nat Biotechnol 8 September (Epub ahead of print).
    • (2013) Nat Biotechnol
    • Zangi, L.1    Lui, K.2    Von Gise, A.3    Ma, Q.4    Ebina, W.5    Ptaszek, L.6
  • 161
    • 0028173338 scopus 로고
    • Self-replicating Semliki Forest virus RNA as recombinant vaccine
    • Zhou, X., Berglund, P., Rhodes, G., Parker, S., Jondal, M. and Liljeström, P. (1994) Self-replicating Semliki Forest virus RNA as recombinant vaccine. Vaccine 12: 1510–1514.
    • (1994) Vaccine , vol.12 , pp. 1510-1514
    • Zhou, X.1    Berglund, P.2    Rhodes, G.3    Parker, S.4    Jondal, M.5    Liljeström, P.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.