Design of multifunctional non-viral gene vectors to overcome physiological barriers: Dilemmas and strategies

International Journal of Pharmaceutics

Volumn 427, Issue 1, 2012, Pages 3-20

  Wang, Tao ^a   Upponi, Jaydev R ^a   Torchilin, Vladimir P ^a  

^a NORTHEASTERN UNIVERSITY   (United States)

Author keywords

Cytoplamic delivery; Delivery barriers; Long circulation; Multifunctional non viral gene vectors; Nuclear import; Targeted delivery

Indexed keywords

1,2 DILINOLEYLOXY N,N DIMETHYL 3 AMINOPROPANE; 1,2 DIOLEOYL 3 TRIMETHYLAMMONIOPROPANE; 2,2 DILINOLEYL 4 (2 DIMETHYLAMINOETHYL)[1,3]DIOXOLANE; ARGINYLGLYCYLASPARTIC ACID; BEVACIZUMAB; CELL PENETRATING PEPTIDE; CHITOSAN; CHOLESTEROL; COPOLYMER; CYCLODEXTRIN; DIOLEOYLPHOSPHATIDYLCHOLINE; DIOLEOYLPHOSPHATIDYLETHANOLAMINE; DISTEAROYLPHOSPHATIDYLCHOLINE; DISTEAROYLPHOSPHATIDYLETHANOLAMINE; GLYCEROPHOSPHOLIPID; LIPID; LIPOPLEX; MACROGOL; MACROGOL 2000; N,N DIOLEOYL N,N DIMETHYLAMMONIUM CHLORIDE; OLIGODEOXYNUCLEOTIDE; PLASMID DNA; POLY(METHACRYLOYL SULFADIMETHOXINE B ETHYLENE GLYCOL); POLYAMIDOAMINE; POLYCATION; POLYETHYLENEIMINE; POLYLYSINE; SMALL INTERFERING RNA; TRASTUZUMAB; UNCLASSIFIED DRUG; UNINDEXED DRUG;

CELL NUCLEUS; COMPLEX FORMATION; CONJUGATE; CONJUGATION; CONTROLLED RELEASE FORMULATION; ENDOSOME; GENE TRANSFER; GENE VECTOR; HUMAN; INTERNALIZATION; INTRACELLULAR TRANSPORT; LIPOSOMAL DELIVERY; MATERIAL COATING; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; OXIDATION REDUCTION REACTION; PH; PRIORITY JOURNAL; REVIEW; VIRAL GENE DELIVERY SYSTEM;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; BLOOD CIRCULATION TIME; CELL NUCLEUS; DRUG CARRIERS; ENDOSOMES; GENE TARGETING; GENE THERAPY; GENE TRANSFER TECHNIQUES; HUMANS; MACACA FASCICULARIS; MICE; MICE, INBRED STRAINS; NEOPLASMS; POLYAMINES; POLYETHYLENE GLYCOLS;

EID: 84255193135     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.07.013     Document Type: Review

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