Particle size and activation threshold: A new dimension of danger signaling

Blood

Volumn 115, Issue 22, 2010, Pages 4533-4541

  Rettig, Lorna ^a   Haen, Sebastian P ^a,d   Bittermann, Anne Greet ^b   Von Boehmer, Lotta ^a   Curioni, Alessandra ^a   Krämer, Stefanie D ^c   Knuth, Alexander ^a   Pascolo, Steve ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c ETH ZURICH   (Switzerland)

^d UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; ELECTROLYTE; NANOPARTICLE; PROTAMINE; SINGLE STRANDED RNA; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; CPG OLIGONUCLEOTIDE; CPG-OLIGONUCLEOTIDE; IMMUNOLOGICAL ADJUVANT; MEMBRANE PROTEIN; OLIGODEOXYRIBONUCLEOTIDE; RNA; TLR7 PROTEIN, MOUSE; TOLL LIKE RECEPTOR 7;

ANIMAL CELL; ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; INNATE IMMUNITY; MICROMORPHOLOGY; MONOCYTE; MOUSE; NONHUMAN; PARTICLE SIZE; PATHOGENICITY; PHAGOCYTOSIS; PLASMACYTOID DENDRITIC CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CHEMISTRY; DENDRITIC CELL; GENETICS; IMMUNOLOGY; IN VITRO STUDY; MOUSE MUTANT; NUCLEOTIDE SEQUENCE; RNA STABILITY;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; BASE SEQUENCE; DENDRITIC CELLS; HUMANS; IMMUNITY, INNATE; INTERFERON-ALPHA; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NANOPARTICLES; OLIGODEOXYRIBONUCLEOTIDES; PARTICLE SIZE; PHAGOCYTOSIS; PROTAMINES; RNA; RNA STABILITY; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 7; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77953931139     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2009-11-247817     Document Type: Article

References (24)

1. Takeda K, Kaisho T, Akira S. Toll-like receptors. Annu Rev Immunol. 2003;21:335-376.
2. Lacour J, Lacour F, Spira A, et al. Adjuvant treatment with polyadenylic-polyuridylic acid (Polya. Polyu) in operable breast cancer. Lancet. 1980; 2(8187):161-164. (Pubitemid 10084713)
3. Levy HB, Law LW, Rabson AS. Inhibition of tumor growth by polyinosinic-polycytidylic acid. Proc Natl Acad Sci U S A. 1969;62(2):357-361.
4. Krieg AM, Yi AK, Matson S, et al. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature. 1995;374(6522):546-549.
5. Hartmann G, Battiany J, Poeck H, et al. Rational design of new CpG oligonucleotides that combine B cell activation with high IFN-alpha induction in plasmacytoid dendritic cells. Eur J Immunol. 2003;33(6):1633-1641. (Pubitemid 36790424)
6. Baron S, Bogomolova NN, Billiau A, et al. Induction of interferon by preparations of synthetic single-stranded RNA. Proc Natl Acad Sci U S A. 1969;64(1):67-74.
7. Billiau A, Buckler CE, Dianzani F, Uhlendorf C, Baron S. Induction of the interferon mechanism by single-stranded RNA: potentiation by polybasic substances. Proc Soc Exp Biol Med. 1969; 132(2):790-796.
8. Scheel B, Braedel S, Probst J, et al. Immunostimulating capacities of stabilized RNA molecules. Eur J Immunol. 2004;34(2):537-547. (Pubitemid 39255964)
9. Scheel B, Aulwurm S, Probst J, et al. Therapeutic anti-tumor immunity triggered by injections of immunostimulating single-stranded RNA. Eur J Immunol. 2006;36(10):2807-2816. (Pubitemid 44608463)
10. Scheel B, Teufel R, Probst J, et al. Toll-like receptor- dependent activation of several human blood cell types by protamine-condensed mRNA. Eur J Immunol. 2005;35(5):1557-1566. (Pubitemid 40691436)
11. Heil F, Hemmi H, Hochrein H, et al. Species-specific recognition of single-stranded RNAvia Toll-like receptor 7 and 8. Science. 2004;303(5663):1526- 1529. (Pubitemid 38314424)
12. Lund JM, Alexopoulou L, Sato A, et al. Recognition of single-stranded RNA viruses by Toll-like receptor 7. Proc Natl Acad Sci U S A. 2004; 101(15):5598-5603. (Pubitemid 38481202)
13. Diebold SS, Kaisho T, Hemmi H, Akira S, Reis e Sousa C. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science. 2004;303(5663):1529-1531. (Pubitemid 38314425)
14. Diebold SS, Massacrier C, Akira S, Paturel C, Morel Y, Reis e Sousa C. Nucleic acid agonists for Toll-like receptor 7 are defined by the presence of uridine ribonucleotides. Eur J Immunol. 2006;36(12):3256-3267.
15. Hornung V, Guenthner-Biller M, Bourquin C, et al. Sequence-specific potent induction of IFN-alpha by short interfering RNAin plasmacytoid dendritic cells through TLR7. Nat Med. 2005;11(3):263-270.
16. Li SD, Huang L. Pharmacokinetics and biodistribution of nanoparticles. Mol Pharm. 2008;5(4): 496-504.
17. Fukada T, Kawade Y, Ujihara M, Shin C, Shima T. Interference with virus infection induced by RNA in chick embryo cells. Jpn J Microbiol. 1968;12(3):329-341.
18. Feyerabend S, Stevanovic S, Gouttefangeas C, et al. Novel multi-peptide vaccination in HLA-A2+ hormone sensitive patients with biochemical relapse of prostate cancer. Prostate. 2009;69(9):917-927.
19. Weide B, Pascolo S, Scheel B, et al. Direct injection of protamine-protected mRNA: results of a phase 1/2 vaccination trial in metastatic melanoma patients. J Immunother. 2009;32(5):498-507.
20. Kerkmann M, Lochmann D, Weyermann J, et al. Immunostimulatory properties of CpG-oligonucleotides are enhanced by the use of protamine nanoparticles. Oligonucleotides. 2006;16(4):313-322.
21. Kerkmann M, Costa LT, Richter C, et al. Spontaneous formation of nucleic acid-based nanoparticles is responsible for high interferon-alpha induction by CpG-A in plasmacytoid dendritic cells. J Biol Chem. 2005;280(9):8086-8093.
22. Reich CF 3rd, Pisetsky DS. The content of DNA and RNA in microparticles released by Jurkat and HL-60 cells undergoing in vitro apoptosis. Exp Cell Res. 2009;315(5):760-768.
23. Distler JH, Pisetsky DS, Huber LC, Kalden JR, Gay S, Distler O. Microparticles as regulators of inflammation: novel players of cellular crosstalk in the rheumatic diseases. Arthritis Rheum. 2005; 52(11):3337-3348.
24. Horstman LL, Jy W, Minagar A, et al. Cell-derived microparticles and exosomes in neuroinflammatory disorders. Int Rev Neurobiol. 2007;79:227-268.