Nonviral transfection of distinct types of human dendritic cells: High-efficiency gene transfer by electroporation into hematopoietic progenitor- but not monocyte-derived dendritic cells

Gene Therapy

Volumn 5, Issue 5, 1998, Pages 700-707

  Van Tendeloo, V F I ^a,b   Snoeck, H W ^a   Lardon, F ^a   Vanham, G L E E ^c   Nijs, G ^a   Lenjou, M ^a   Hendriks, L ^b   Van Broeckhoven, C ^b   Moulijn, A ^d   Rodrigus, I ^d   Verdonk, P ^e   Van Bockstaele, D R ^a   Berneman, Z N ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^c Institute of Tropical Medicine (ITG)

^d ANTWERP UNIVERSITY HOSPITAL   (Belgium)

^e MIDDELHEIM HOSPITAL   (Belgium)

Author keywords

Dendritic cells; Electroporation; Flow cytometry; Gene transfer; Green fluorescent protein; Transfection efficiency

Indexed keywords

CD34 ANTIGEN; GREEN FLUORESCENT PROTEIN; PLASMID DNA;

ANTIGEN PRESENTING CELL; ARTICLE; CONTROLLED STUDY; DENDRITIC CELL; DNA TRANSFECTION; ELECTROPORATION; GENE TRANSFER; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; LANGERHANS CELL; MONOCYTE; PRIORITY JOURNAL; REPORTER GENE;

EID: 7144250527     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3300626     Document Type: Article

References (30)

1. Steinman RM The dendritic cell system and its role in immuno genicity. Annu Rev Immunol 1991; 9: 271-296.
2. Marland G, Bakker AB, Adema G, Figdor CG. Dendritic cells in immune response induction. Stem Cells 1996; 14: 501-507.
3. Lardon F et al. Generation of dendritic cells from bone marrow progenitors using GM-CSF, TNF-α and additional cytokines: antagonistic effects of IL-4 and IFN-γ and selective involvement of TNF-α receptor-1. Immunology 1997; 91: 553-559.
4. Caux C, Dezutter-Dambuyant C, Schmitt D, Bancherau J. GM-CSF and TNF-α cooperate in the generation of dendritic Langerhans' cells. Nature 1992; 360: 258-261.
5. + blood progenitors for anticancer therapy. Exp Hematol 1995; 23: 1463-1471.
6. + hematopoietic progenitor cells toward distinct dendritic cell subsets of the Birbeck granule and MIIC-positive Langerhans' cell and the interdigitating dendritic cell type. Blood 1996; 88: 2541-2548.
7. Romani N et al. Proliferating dendritic cell progenitors in human blood. J Exp Med 1994; 180: 83-93.
8. Grabbe S, Beissert S, Schwarz T, Granstein RD. Dendritic cells as initiators of tumor immune responses: a possible strategy for tumor immunotherapy. Immunol Today 1995; 16: 117-121.
9. Young JW, Inaba K. Dendritic cells as adjuvants for class I major histocompatibility complex-restricted antitumor immunity. J Exp Med 1996; 183: 7-11.
10. Shurin MR. Dendritic cells presenting tumor antigen. Cancer Immunol Immunother 1996; 43: 158-164.
11. Henderson RA et al. Human dendritic cells genetically engineered to express high levels of the human epithelial tumor antigen Mucin (MUC-1). Cancer Res 1996; 56: 3763-3770.
12. Reeves ME et al. Retroviral transduction of human dendritic cells with a tumor-associated antigen gene. Cancer Res 1996; 56: 5672-5677.
13. Aicher A et al. Succesful retroviral mediated transduction of a reporter gene in human dendritic cells: feasibility of therapy with gene-modified antigen presenting cells. Exp Hematol 1997; 25: 39-44.
14. Alijagic S et al. Dendritic cells generated from peripheral blood transfected with human tyrosinase induce specific T cell activation. Eur J Immunol 1995; 25: 3100-3107.
15. Arthur JF et al. A comparison of gene transfer methods in human dendritic cells. Cancer Gene Ther 1997; 4: 17-25.
16. Van Elsas A et al. Peptide-pulsed dendritic cells induce tumoricidal cytotoxic T lymphocytes from healthy donors against stably HLA-A*0201-binding peptides from the Melan-A/MART-1 self antigen. Eur J Immunol 1996; 26: 1683-1689.
17. Choudhury A et al. Use of leukemic dendritic cells for the generation of antileukemic cellular cytotoxicity against Philadelphia chromosome-positive chronic myelogenous leukemia. Blood 1997; 89: 1133-1142.
18. Bakker ABH et al. Generation of antimelanoma cytotoxic T lymphocytes from healthy donors after presentation of melanoma-associated antigen-derived epitopes by dendritic cells in vitro. Cancer Res 1995; 55: 5330-5334.
19. Gabrilovich DI et al. Dendritic cells grown from bone marrow precursors, but not mature DC from tumor-bearing mice, are effective antigen carriers in the therapy of established tumors. Cell Immunol 1996; 170: 111-119.
20. Porgador A, Snyder D, Gilboa E. Induction of antitumor immunity using bone marrow-generated dendritic cells. J Immunol 1996; 156: 2918-2926.
21. Hsu FJ et al. Vaccination of patients with B cell lymphoma using autologous antigen-pulsed dendritic cells. Nature Med 1996; 2: 52-58.
22. Boon T, van der Bruggen P. Human tumor antigens recognized by T-lymphocytes. J Exp Med 1996; 183: 725-729.
23. Brodsky FM, Guagliardi LE. The cell biology of antigen processing. Annu Rev Immunol 1991; 9: 707-744.
24. Cormack BP, Valdivia RH, Falkow S. FACS-optimized mutants of the green fluorescent protein (GFP). Gene 1996; 173: 33-38.
25. Condon C et al. DNA-based immunization by in vivo transfection of dendritic cells. Nature Med 1996; 2: 1122-1128.
26. Thomas R, Lipsky PE. Dendritic cells: origin and differentiation. Stem Cells 1996; 14: 196-206.
27. Watts C. Inside the gearbox of the dendritic cell. Nature 1997; 388: 724-725.
28. Triozzi PL, Aldrich W. Phenotypic and functional differences between human dendritic cells derived from hematopoietic progenitors and from monocytes/macrophages. j Leuk Biol 1997; 61: 600-608.
29. + peripheral blood monocytes. J Immunol 1996; 157: 3850-3859.
30. Bühring HJ et al. The product of the proto-oncogene c-kit (P145c-kit) is a human bone marrow surface antigen of hematopoietic precursor cells which is expressed on a subset of acute nonlymphoblastic leukemic cells. Leukemia 1991; 5: 854-860.