Selective uptake of naked vaccine RNA by dendritic cells is driven by macropinocytosis and abrogated upon DC maturation

Gene Therapy

Volumn 18, Issue 7, 2011, Pages 702-708

  Diken, M ^a   Kreiter, S ^a   Selmi, A ^a   Britten, C M ^b   Huber, C ^c   Tureci O ^d   Sahin, U ^a,b,c  

^a Institute for Translational Oncology and Immunology (TRON)   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

^c BIONTECH AG   (Germany)

^d Ganymed Pharmaceuticals AG   (Germany)

Author keywords

dendritic cells; macropinocytosis; RNA; Vaccination

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; AMILORIDE; CYTOCHALASIN D; POLYINOSINIC POLYCYTIDYLIC ACID; RNA VACCINE; ROTTLERIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BIOLUMINESCENCE; CELL MATURATION; CONTROLLED STUDY; DENDRITIC CELL; DRUG UPTAKE; FLOW CYTOMETRY; GENE DELIVERY SYSTEM; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOTHERAPY; IN VITRO STUDY; IN VIVO STUDY; INTERNALIZATION; LYMPH NODE CELL; MOUSE; NONHUMAN; PINOCYTOSIS; PRIORITY JOURNAL;

ANIMALS; CELL DIFFERENTIATION; DENDRITIC CELLS; GENE TRANSFER TECHNIQUES; LYMPH NODES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; PINOCYTOSIS; RNA;

MURINAE;

EID: 79960145796     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/gt.2011.17     Document Type: Article

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