+1 Frameshifting as a novel mechanism to generate a cryptic cytotoxic T lymphocyte epitope derived from human interleukin 10

Journal of Experimental Medicine

Volumn 195, Issue 3, 2002, Pages 353-358

  Saulquin, Xavier ^a   Scotet, Emmanuel ^a   Trautmann, Lydie ^a   Peyrat, Marie Alix ^a   Halary, Franck ^a   Bonneville, Marc ^a   Houssaint, Elisabeth ^a  

^a INSTITUT DE BIOLOGIE   (France)

Author keywords

Autoimmunity; CTL; Epitope; Frameshift; IL 10

Indexed keywords

DNA; EPITOPE; HLA B ANTIGEN; INTERLEUKIN 10;

ANIMAL CELL; ANTIGEN RECOGNITION; ARTICLE; AUTOIMMUNITY; CASE REPORT; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DNA TRANSFECTION; GENE SEQUENCE; HUMAN; HUMAN CELL; LYMPHOCYTE CLONE; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; REITER SYNDROME; RIBOSOMAL FRAMESHIFTING; SITE DIRECTED MUTAGENESIS; SYNOVIAL FLUID; T LYMPHOCYTE ACTIVATION;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CLONE CELLS; COS CELLS; DNA, COMPLEMENTARY; EPITOPES; FRAMESHIFT MUTATION; FRAMESHIFTING, RIBOSOMAL; HLA-B ANTIGENS; HUMANS; INTERLEUKIN-10; MODELS, GENETIC; MODELS, IMMUNOLOGICAL; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; OPEN READING FRAMES; REITER SYNDROME; T-LYMPHOCYTES, CYTOTOXIC; TRANSFECTION;

EID: 0037017382     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20011399     Document Type: Article

References (22)

1. Non-traditionally derived CTL epitopes: Exceptions that prove the rules?
2. An alternative translational reading frame encodes an immunodominant retroviral CTL determinant expressed by an immunodeficiency-causing retrovirus
3. Recognition of out-of-frame major histocompatibility complex class I-restricted epitopes in vivo
4. Ribosomal scanning past the primary initiation codon as a mechanism for expression of CTL epitopes encoded in alternative reading frames
5. Utilization of an alternative open reading frame of a normal gene in generating a novel human cancer antigen
6. Presentation of out-of-frame peptide/MHC class I complexes by a novel translation initiation mechanism
7. A new antigen recognized by cytolytic T lymphocytes on a human kidney tumor results from reverse strand transcription
8. A peptide recognized by human cytolytic T lymphocytes on HLA-A2 melanomas is encoded by an intron sequence of the N-acetylglucosaminenyltransferase V gene
9. Frequent enrichment for CD8 T cells reactive against common herpes viruses in chronic inflammatory lesions: Towards a reassessment of the physiopathological significance of T cell clonal expansions found in autoimmune inflammatory processes
10. Frequent recognition of BCRF1, a late lytic cycle protein of Epstein-Barr virus, in the HLA-B*2705 context. Evidence for a TAP-independent processing
11. Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: Homology to Epstein-Barr virus open reading frame BCRF1
12. Downregulation of TAP1 in B lymphocytes by cellular and Epstein-Barr virus-encoded interleukin-10
13. Programmed ribosomal frameshifting: Much ado about knotting
14. Identification and characterization of a developmentally regulated mammalian gene that utilizes-1 programmed ribosomal frameshifting
15. Identification of putative programmed -1 ribosomal frameshift signals in large DNA databases
16. Slippery runs, shifty stops, backward steps, and forward hopes: -2, -1, +1, +2, +5, +6 ribosomal frameshifting
17. Autoregulatory frameshifting in decoding mammalian omithine decarboxylase antizyme
18. Programmed translational frameshifting
19. A rare t-RNA-Arg (CUU) that regulates Ty1 element ribosomal frameshifting is essential for Ty1 retrotransposition in Saccharomyces cerevisiae
20. A novel programmed frameshift expresses the POL3 gene of retrotransposon Ty3 of yeast: Frameshifting without tRNA slippage
21. Elevated interleukin-10 levels in patients with rheumatoid arthritis
22. + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis