Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability

Molecular Therapy

Volumn 16, Issue 11, 2008, Pages 1833-1840

  Karikó, Katalin ^a   Muramatsu, Hiromi ^a   Welsh, Frank A ^a   Ludwig, János ^b   Kato, Hiroki ^c   Akira, Shizuo ^c   Weissman, Drew ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

^c OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; MESSENGER RNA; PSEUDOURIDINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA MODIFICATION; FEMALE; GENE FUNCTION; GENE INSERTION; GENE REPLACEMENT THERAPY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOGENICITY; IMMUNOMODULATION; MAMMAL CELL; MOUSE; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RNA TRANSLATION; RNA VECTOR; TRANSLATION REGULATION; VACCINATION;

ANIMALS; CELL LINE; GENETIC VECTORS; HUMANS; LUCIFERASES; MICE; PROTEIN BIOSYNTHESIS; PSEUDOURIDINE; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

MAMMALIA; MUS;

EID: 54949112814     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2008.200     Document Type: Article

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