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This study showed that allergen gene-transfected immature dendritic cells could induce T regulatory cells to downregulate established Th2-allergic responses
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Lee BC, O'Sullivan I, Kim E, et al. A DNA adjuvant encoding a fusion protein between anti-CD3 single-chain Fv and AIMP1 enhances T helper type 1 cell- mediated immune responses in antigen-sensitized mice. Immunology. doi:10.1111/j.1365-2567.2008.02880.x (in press). This study described a promising strategy to downregulate established Th2 allergic responses using a novel genetic adjuvant.
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This study showed the first time that DAI was a cytoplasmic DNA sensor and activated the innate immune response through TBK1 and IRF3
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This study showed the molecular mechanisms for DAI activation and regulatory mechanisms for cytoplasmic DNA induced innate immunity
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Wang Z, Choi MK, Ban T, et al. Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules. Proc Natl Acad Sci USA 2008; 105:5477-5482. This study showed the molecular mechanisms for DAI activation and regulatory mechanisms for cytoplasmic DNA induced innate immunity.
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Wang, Z.1
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