Presentation of out-of-frame peptide/MHC class I complexes by a novel translation initiation mechanism

Immunity

Volumn 10, Issue 6, 1999, Pages 681-690

  Malarkannan, Subramaniam ^a   Horng, Tiffany ^a   Shih, Patty P ^a   Schwab, Susan ^b   Shastri, Nilabh ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1;

ANIMAL CELL; ANIMAL TISSUE; ANTIGEN PRESENTATION; ARTICLE; CODON; COMPLEX FORMATION; CONTROLLED STUDY; DNA REPLICATION; GENE CONSTRUCT; GENETIC TRANSFECTION; IMMUNOSURVEILLANCE; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEQUENCE ANALYSIS; T LYMPHOCYTE ACTIVATION; TRANSLATION INITIATION;

EID: 0033151592     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80067-9     Document Type: Article

References (49)

1. Boeck, R., and Kolakofsky, D. (1994). Positions +5 and +6 can be major determinants of the efficiency of non-AUG initiation codons for protein synthesis. EMBO J. 13, 3608-3617.
2. Boon, T., and Van Pel, A. (1989). T cell-recognized antigenic peptides derived from the cellular genome are not protein degradation products but can be generated directly by transcription and translation of short subgenic regions. A hypothesis. Immunogenetics 29, 75-79.
3. Boon, T., Van Pel, A., De Plaen, E., Chomez, P., Lurquin, C., Szikora, J.-P., Sibille, C., Mariame, B., Van Den Eynde, B., Lethe, B., and Brichard, V. (1989). Genes coding for T-cell-defined turn transplantation antigens: Point mutations, antigenic peptides, and subgenic expression. Cold Spring Harbor Symp. Quant. Biol. 54, 587-596.
4. Bullock, T.N.J., and Eisenlohr, L.C. (1996). Ribosomal scanning past the primary initiation codon as a mechanism for expression of CTL epitopes encoded in alternative reading frames. J. Exp. Med. 184, 1319-1329.
5. Bullock, T.N.J., Patterson, A.E., Franlin, L.L., Notidis, E., and Eisenlohr, L.C. (1997). Initiation codon scanthrough versus termination codon readthrough demonstrates strong potential for major histocompatibility complex class I-restricted cryptic epitope expression. J. Exp. Med. 186, 1051-1058.
6. Chen, C.Y., and Sarnow, P. (1995). Initiation of protein synthesis by the eukaryotic translational apparatus on circular RNAs. Science 268, 415-417.
7. Met functions in directing the scanning ribosome to the start site of translation. Science 242, 93-97.
8. Dolstra, H., Fredrix, H., Maas, F., Coulie, P.G., Brasseur, F., Mensink, E., Adema, G.J., de Witte, T.M., Figdor, C.G., Wiel-Van, V.D., and Kemenade, E. (1999). A human minor histocompatibility antigen specific for B cell acute lymphoblastic leukemia. J. Exp. Med. 189, 301-308.
9. Drabkin, H.J., and Rajbhandary, U.L. (1998). Initiation of protein synthesis in mammalian cells with codons other than AUG and amino acids other than methionine. Mol. Cell. Biol. 18, 5140-5147.
10. Elliott, T., Bodmer, H., and Townsend, A. (1996). Recognition of out-of-frame major histocompatibility complex class I-restricted epitopes in vivo. Eur. J. Immunol. 26, 1175-1179.
11. Engelberg-Kulka, H., and Schoulaker-Schwarz, R. (1994). Regulatory implications of translational frameshifting in cellular gene expression. Mol. Microbiol. 11, 3-8.
12. Falk, K., Rötzschke, O., and Rammensee, H.-G. (1990). Cellular peptide composition governed by major histocompatibility complex class I molecules. Nature 348, 248-251.
13. Falk, K., Rotzschke, O., Stevanovic, S., Jung, G., and Rammensee, H.-G. (1991). Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules. Nature 351, 290-296.
14. Fetten, J.V., Roy, N., and Gilboa, E. (1991). A frameshift mutation at the NH2 terminus of the nucleoprotein gene does not affect generation of cytotoxic T lymphocyte epitopes. J. Immunol. 147, 2697-2705.
15. Gooding, L.R., O'Connell, K.A., Geib, R.W., and Pipas, J.M. (1988). Cytotoxic T cell recognition of the SV40 tumor antigen: A note of caution. In Processing and Presentation of Antigens, B. Pernis, S. Silverstein, and H. Vogel, eds. (New York: Academic Press), pp. 87-95.
16. Hahn, Y.S., Braciale, V.L., and Braciale, T.J. (1991). Presentation of viral antigen to class I major histocompatibility complex-restricted cytotoxic T lymphocyte. Recognition of an immunodominant influenza hemagglutinin site by cytotoxic T lymphocyte is independent of the position of the site in the hemagglutinin translation product. J. Exp. Med. 174, 733-736.
17. Hunt, D.F., Henderson, R.A., Shabanowitz, J., Sakaguchi, K., Michel, H., Sevilir, N., Cox, A.L., Appella, E., and Engelhard, V.H. (1992). Characterization of peptides bound to the class I MHC molecule HLA-A2.1 by mass spectrometry. Science 255, 1261-1263.
18. Jacks, T., Power, M.D., Masiarz, F.R., Luciw, P.A., Barr, P.J., and Varmus, H.E. (1988). Characterization of ribosomal frameshifting in HIV-1 gag-pol expression. Nature 331, 280-283.
19. Janosi, L., Mottagui-Tabar, S., Isaksson, L.A., Sekine, Y., Ohtsubo, E., Zhang, S., Goon, S., Nelken, S., Shuda, M., and Kaji, A. (1998). Evidence for in vivo ribosome recycling, the fourth step in protein biosynthesis. EMBO J. 17, 1141-1151.
20. Karttunen, J., Sanderson, S., and Shastri, N. (1992). Detection of rare antigen presenting cells by the lacZ T-cell activation assay suggests an expression cloning strategy for T-cell antigens. Proc. Natl. Acad. Sci. USA 89, 6020-6024.
21. Kozak, M. (1991). Structural features in eukaryotic mRNAs that modulate the initiation of translation. J. Biol. Chem. 266, 19867-19870.
22. Kozak, M. (1992). Regulation of translation in eukaryotic systems. Annu. Rev. Cell Biol. 8, 197-225.
23. Kozak, M. (1997). Recognition of AUG and alternative initiator codons is augmented by G in position +4 but is not generally affected by the nucleotides in positions +5 and +6. EMBO J. 16, 2482-2492.
24. Lindahl, K.F. (1991). Do we need a pepton hypothesis? Immunogenetics 34, 1-4.
25. b MHC class I molecule to alloreactive T-cells. J. Exp. Med. 182, 1739-1750.
26. Malarkannan, S., Goth, S., Buchholz, D.R., and Shastri, N. (1995b). The role of MHC class I molecules in the generation of endogenous peptide/MHC complexes. J. Immunol. 154, 585-598.
27. Malarkannan, S., Shih, P., Eden, P., Horng, T., Zuberi, A.R., ChristianSon, G., Roopenian, D., and Shastri, N. (1998). The molecular and functional characterization of a dominant minor H antigen, H60. J. Immunol. 161, 3501-3509.
28. Matthias, P., Muller, M.M., Schreiber, E., Rusconi, S., and Schaffner, W. (1989). Eukaryotic expression vectors for the analysis of mutant proteins. Nucleic Acids Res. 17, 6418.
29. Mayrand, S.-M., and Green, W.R. (1998). Non-traditionally derived CTL epitopes: Exceptions that prove the rules? Immunol. Today 19, 551-555.
30. Mayrand, S.M., Schwarz, D.A., and Green, W.R. (1998). An alternative translational reading frame encodes an immunodominant retroviral CTL determinant expressed by an immunodeficiency-causing retrovirus. J. Immunol. 160, 39-50.
31. Neisig, A., Roelse, J., Sijts, A.J.A.M., Ossendorp, F., Feltkamp, M.C.W., Kast, W.M., Melief, C.J.M., and Neefjes, J.J. (1995). Major differences in transporter associated with antigen presentation (TAP)-dependent translocation of MHC class I-presentable peptides and the effect of flanking sequences. J. Immunol. 154, 1273-1279.
32. Nirenberg, M., and Leder, P. (1964). RNA code words and protein synthesis. Science 145, 1399-1407.
33. Ossendorp, F., Eggers, M., Neisig, A., Ruppert, T., Groettrup, M., Sijts, A., Mengede, E., Kloetzel, P.M., Neefjes, J., Koszinowski, U., and Melief, C. (1996). A single residue exchange within a viral CTL epitope alters proteasome-mediated degradation resulting in lack of antigen presentation. Immunity 5, 115-124.
34. Peabody, D.S. (1989). Translation initiation at non-AUG triplets in mammalian cells. J. Biol. Chem. 264, 5031-5035.
35. Pestova, T.V., Borukhov, S.I., and Hellen, C.U.T. (1998). Eukaryotic ribosomes require initiation factors 1 and 1A to locate initiation codons. Nature 394, 854-859.
36. Rajbhandary, U.L., and Chow, C.M. (1995). Initiator tRNAs and initiation of protein synthesis. In tRNA: Structure, Biosynthesis, and Function, D. Soll and U.L. Rajbhandary, eds. (Washington, D.C.: American Society of Microbiology), pp. 511-528.
37. Reynolds, J.E., Kaminski, A., Kettinen, H.J., Grace, K., Clarke, B.E., Carroll, A.R., Rowlands, D.J., and Jackson, R.J. (1995). Unique features of internal initiation of hepatitis C virus RNA translation. EMBO J. 14, 6010-6020.
38. Rotzschke, O., Falk, K., Wallny, H.-J., Faath, S., and Rammensee, H.-G. (1990). Characterization of naturally occurring minor histocompatibility peptides including H-4 and H-Y. Science 249, 283-287.
39. Sanderson, S., and Shastri, N. (1994). LacZ inducible peptide/MHC specific T-hybrids. Int. Immunol. 6, 369-376.
40. b complex to T-cells. J. Immunol. 150, 2724-2736.
41. Shastri, N., Nguyen, V., and Gonzalez, F. (1995). Major histocompatibility class I molecules can present cryptic translation products to T-cells. J. Biol. Chem. 270, 1088-1091.
42. Shichijo, S., Nakao, M., Imai, Y., Takasu, H., Kawamoto, M., Niiya, F., Yang, D., Toh, Y., Yamma, H., and Itoh, K. (1998). A gene encoding antigenic peptides of human squamous cell carcinoma recognized by cytotoxic T lymphocytes. J. Exp. Med. 187, 277-288.
43. Sonenberg, N. (1990). Poliovirus translation. Curr. Top. Microbiol. Immunol. 161, 23-47.
44. Sykulev, Y., Joo, M., Vturina, I., Tsomides, T.J., and Eisen, H.N. (1996). Evidence that a single peptide-MHC complex on a target cell can elicit a cytolytic T cell response. Immunity 4, 565-571.
45. Uenaka, A., Ono, T., Akisawa, T., Wada, H., Yasuda, T., and Nakayama, E. (1994). Identification of a unique antigen peptide pRL1 on BALB-c RL 1 leukemia recognized by cytotoxic T lymphocytes and its relation to the Akt oncogene. J. Exp. Med. 180, 1599-1607.
46. Wang, R.-F., Parkhurst, M.R., Kawakami, Y., Robbins, P.F., and Rosenberg, S.A. (1996). Utilization of an alternative open reading frame of a normal gene in generating a novel human cancer antigen. J. Exp. Med. 183, 1131-1140.
47. Wang, R.-F., Johnston, S.L., Zeng, G., Topalian, S.L., Schwartzentruber, D.J., and Rosenberg, S. (1998). A breast and melanoma-shared tumor antigen: T cell responses to antigenic peptides translated from different open reading frames. J. Immunol. 161, 3596-3606.
48. Yewdell, J.W., Anton, L.C., and Bennink, J.R. (1996). Defective ribosomal products (DRiPs): A major source of antigenic peptides for MHC class I molecules? J. Immunol. 157, 1823-1826.
49. Yoon, H.J., and Donahue, T.F. (1992). The suil suppressor locus in saccharomyces cerevisiae encodes a translation factor that functions during tRNA(iMet) recognition of the start codon. Mol. Cell. Biol. 12, 248-260.