-
1
-
-
0036365052
-
In vivo targeting of SF/HGF and c-met expression via U1snRNA/ribozymes inhibits glioma growth and angiogenesis and promotes apoptosis
-
Abounader R, Lal B, Luddy C, Koe G, Davidson B, Rosen EM, et al: In vivo targeting of SF/HGF and c-met expression via U1snRNA/ribozymes inhibits glioma growth and angiogenesis and promotes apoptosis. FASEB J 16:108-110, 2002
-
(2002)
FASEB J
, vol.16
, pp. 108-110
-
-
Abounader, R.1
Lal, B.2
Luddy, C.3
Koe, G.4
Davidson, B.5
Rosen, E.M.6
-
2
-
-
0033568455
-
Reversion of human glioblastoma malignancy by U1 small nuclear RNA/ribozyme targeting of scatter factor/ hepatocyte growth factor and c-met expression
-
Abounader R, Ranganathan S, Lal B, Fielding K, Book A, Dietz H, et al: Reversion of human glioblastoma malignancy by U1 small nuclear RNA/ribozyme targeting of scatter factor/ hepatocyte growth factor and c-met expression. J Natl Cancer Inst 91:1548-1556, 1999
-
(1999)
J Natl Cancer Inst
, vol.91
, pp. 1548-1556
-
-
Abounader, R.1
Ranganathan, S.2
Lal, B.3
Fielding, K.4
Book, A.5
Dietz, H.6
-
3
-
-
33749499603
-
Tumor stromal-derived factor-1 recruits vascular progenitors to mitotic neovasculature, where microenvironment influences their differentiated phenotypes
-
Aghi M, Cohen KS, Klein RJ, Scadden DT, Chiocca EA: Tumor stromal-derived factor-1 recruits vascular progenitors to mitotic neovasculature, where microenvironment influences their differentiated phenotypes. Cancer Res 66:9054-9064, 2006
-
(2006)
Cancer Res
, vol.66
, pp. 9054-9064
-
-
Aghi, M.1
Cohen, K.S.2
Klein, R.J.3
Scadden, D.T.4
Chiocca, E.A.5
-
4
-
-
67649446851
-
SNS-032 prevents hypoxia-mediated glioblastoma cell invasion by inhibiting hypoxia inducible factor-1alpha expression
-
Ali MA, Reis A, Ding LH, Story MD, Habib AA, Chattopadhyay A, et al: SNS-032 prevents hypoxia-mediated glioblastoma cell invasion by inhibiting hypoxia inducible factor-1alpha expression. Int J Oncol 34:1051-1060, 2009
-
(2009)
Int J Oncol
, vol.34
, pp. 1051-1060
-
-
Ali, M.A.1
Reis, A.2
Ding, L.H.3
Story, M.D.4
Habib, A.A.5
Chattopadhyay, A.6
-
5
-
-
0038323916
-
Hypoxia promotes murine bone-marrow-derived stromal cell migration and tube formation
-
Annabi B, Lee YT, Turcotte S, Naud E, Desrosiers RR, Champagne M, et al: Hypoxia promotes murine bone-marrow-derived stromal cell migration and tube formation. Stem Cells 21:337-347, 2003
-
(2003)
Stem Cells
, vol.21
, pp. 337-347
-
-
Annabi, B.1
Lee, Y.T.2
Turcotte, S.3
Naud, E.4
Desrosiers, R.R.5
Champagne, M.6
-
6
-
-
4744353220
-
Sumoylation increases HIF-1alpha stability and its transcriptional activity
-
Bae SH, Jeong JW, Park JA, Kim SH, Bae MK, Choi SJ, et al: Sumoylation increases HIF-1alpha stability and its transcriptional activity. Biochem Biophys Res Commun 324:394-400, 2004
-
(2004)
Biochem Biophys Res Commun
, vol.324
, pp. 394-400
-
-
Bae, S.H.1
Jeong, J.W.2
Park, J.A.3
Kim, S.H.4
Bae, M.K.5
Choi, S.J.6
-
7
-
-
0033416032
-
Stimulation of glucose transport by hypoxia: signals and mechanisms
-
Behrooz A, Ismail-Beigi F: Stimulation of glucose transport by hypoxia: signals and mechanisms. News Physiol Sci 14:105-110, 1999
-
(1999)
News Physiol Sci
, vol.14
, pp. 105-110
-
-
Behrooz, A.1
Ismail-Beigi, F.2
-
8
-
-
47949099628
-
Modes of resistance to anti-angiogenic therapy
-
Bergers G, Hanahan D: Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer 8:592-603, 2008
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 592-603
-
-
Bergers, G.1
Hanahan, D.2
-
9
-
-
24744460523
-
Arrest-defective-1 protein, an acetyltransferase, does not alter stability of hypoxia-inducible factor (HIF)-1alpha and is not induced by hypoxia or HIF
-
Bilton R, Mazure N, Trottier E, Hattab M, Déry MA, Richard DE, et al: Arrest-defective-1 protein, an acetyltransferase, does not alter stability of hypoxia-inducible factor (HIF)-1alpha and is not induced by hypoxia or HIF. J Biol Chem 280:31132-31140, 2005
-
(2005)
J Biol Chem
, vol.280
, pp. 31132-31140
-
-
Bilton, R.1
Mazure, N.2
Trottier, E.3
Hattab, M.4
Déry, M.A.5
Richard, D.E.6
-
10
-
-
0020326952
-
Intracranial tumors: response and resistance to therapeutic endeavors, 1970-1980
-
Bloom HJ: Intracranial tumors: response and resistance to therapeutic endeavors, 1970-1980. Int J Radiat Oncol Biol Phys 8:1083-1113, 1982
-
(1982)
Int J Radiat Oncol Biol Phys
, vol.8
, pp. 1083-1113
-
-
Bloom, H.J.1
-
11
-
-
0041382820
-
The hypoxic response of tumors is dependent on their microenvironment
-
Blouw B, Song H, Tihan T, Bosze J, Ferrara N, Gerber HP, et al: The hypoxic response of tumors is dependent on their microenvironment. Cancer Cell 4:133-146, 2003
-
(2003)
Cancer Cell
, vol.4
, pp. 133-146
-
-
Blouw, B.1
Song, H.2
Tihan, T.3
Bosze, J.4
Ferrara, N.5
Gerber, H.P.6
-
12
-
-
13444283313
-
Ras inhibition in glioblastoma down-regulates hypoxia-inducible factor-1alpha, causing glycolysis shutdown and cell death
-
Blum R, Jacob-Hirsch J, Amariglio N, Rechavi G, Kloog Y: Ras inhibition in glioblastoma down-regulates hypoxia-inducible factor-1alpha, causing glycolysis shutdown and cell death. Cancer Res 65:999-1006, 2005
-
(2005)
Cancer Res
, vol.65
, pp. 999-1006
-
-
Blum, R.1
Jacob-Hirsch, J.2
Amariglio, N.3
Rechavi, G.4
Kloog, Y.5
-
13
-
-
84901012573
-
Celastrol targets proteostasis and acts synergistically with a heat-shock protein 90 inhibitor to kill human glioblastoma cells
-
Boridy S, Le PU, Petrecca K, Maysinger D: Celastrol targets proteostasis and acts synergistically with a heat-shock protein 90 inhibitor to kill human glioblastoma cells. Cell Death Dis 5:e1216, 2014
-
(2014)
Cell Death Dis
, vol.5
-
-
Boridy, S.1
Le, P.U.2
Petrecca, K.3
Maysinger, D.4
-
14
-
-
0842325802
-
Pseudopalisades in glioblastoma are hypoxic, express extracellular matrix proteases, and are formed by an actively migrating cell population
-
Brat DJ, Castellano-Sanchez AA, Hunter SB, Pecot M, Cohen C, Hammond EH, et al: Pseudopalisades in glioblastoma are hypoxic, express extracellular matrix proteases, and are formed by an actively migrating cell population. Cancer Res 64:920-927, 2004
-
(2004)
Cancer Res
, vol.64
, pp. 920-927
-
-
Brat, D.J.1
Castellano-Sanchez, A.A.2
Hunter, S.B.3
Pecot, M.4
Cohen, C.5
Hammond, E.H.6
-
15
-
-
0037501724
-
Malignant glioma physiology: cellular response to hypoxia and its role in tumor progression
-
Brat DJ, Mapstone TB: Malignant glioma physiology: cellular response to hypoxia and its role in tumor progression. Ann Intern Med 138:659-668, 2003
-
(2003)
Ann Intern Med
, vol.138
, pp. 659-668
-
-
Brat, D.J.1
Mapstone, T.B.2
-
16
-
-
77958603109
-
Radiosensitization of glioma cells by modulation of Met signalling with the hepatocyte growth factor neutralizing antibody, AMG102
-
Buchanan IM, Scott T, Tandle AT, Burgan WE, Burgess TL, Tofilon PJ, et al: Radiosensitization of glioma cells by modulation of Met signalling with the hepatocyte growth factor neutralizing antibody, AMG102. J Cell Mol Med 15:1999-2006, 2011
-
(2011)
J Cell Mol Med
, vol.15
, pp. 1999-2006
-
-
Buchanan, I.M.1
Scott, T.2
Tandle, A.T.3
Burgan, W.E.4
Burgess, T.L.5
Tofilon, P.J.6
-
17
-
-
32944467848
-
Fully human monoclonal antibodies to hepatocyte growth factor with therapeutic potential against hepatocyte growth factor/c-Met-dependent human tumors
-
Burgess T, Coxon A, Meyer S, Sun J, Rex K, Tsuruda T, et al: Fully human monoclonal antibodies to hepatocyte growth factor with therapeutic potential against hepatocyte growth factor/c-Met-dependent human tumors. Cancer Res 66:1721-1729, 2006
-
(2006)
Cancer Res
, vol.66
, pp. 1721-1729
-
-
Burgess, T.1
Coxon, A.2
Meyer, S.3
Sun, J.4
Rex, K.5
Tsuruda, T.6
-
18
-
-
0033551070
-
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
-
Cantley LC, Neel BG: New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc Natl Acad Sci U S A 96:4240-4245, 1999
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 4240-4245
-
-
Cantley, L.C.1
Neel, B.G.2
-
19
-
-
33846270366
-
Glucose uptake inhibitor sensitizes cancer cells to daunorubicin and overcomes drug resistance in hypoxia
-
Cao X, Fang L, Gibbs S, Huang Y, Dai Z, Wen P, et al: Glucose uptake inhibitor sensitizes cancer cells to daunorubicin and overcomes drug resistance in hypoxia. Cancer Chemother Pharmacol 59:495-505, 2007
-
(2007)
Cancer Chemother Pharmacol
, vol.59
, pp. 495-505
-
-
Cao, X.1
Fang, L.2
Gibbs, S.3
Huang, Y.4
Dai, Z.5
Wen, P.6
-
20
-
-
79958706977
-
RACK1 promotes breast carcinoma migration/metastasis via activation of the RhoA/Rho kinase pathway
-
Cao XX, Xu JD, Xu JW, Liu XL, Cheng YY, Li QQ, et al: RACK1 promotes breast carcinoma migration/metastasis via activation of the RhoA/Rho kinase pathway. Breast Cancer Res Treat 126:555-563, 2011
-
(2011)
Breast Cancer Res Treat
, vol.126
, pp. 555-563
-
-
Cao, X.X.1
Xu, J.D.2
Xu, J.W.3
Liu, X.L.4
Cheng, Y.Y.5
Li, Q.Q.6
-
21
-
-
0032581277
-
Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
-
(Erratum in Nature 395:525, 1998)
-
Carmeliet P, Dor Y, Herbert JM, Fukumura D, Brusselmans K, Dewerchin M, et al: Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 394:485-490, 1998 (Erratum in Nature 395:525, 1998)
-
(1998)
Nature
, vol.394
, pp. 485-490
-
-
Carmeliet, P.1
Dor, Y.2
Herbert, J.M.3
Fukumura, D.4
Brusselmans, K.5
Dewerchin, M.6
-
22
-
-
4043184065
-
Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1
-
Ceradini DJ, Kulkarni AR, Callaghan MJ, Tepper OM, Bastidas N, Kleinman ME, et al: Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1. Nat Med 10:858-864, 2004
-
(2004)
Nat Med
, vol.10
, pp. 858-864
-
-
Ceradini, D.J.1
Kulkarni, A.R.2
Callaghan, M.J.3
Tepper, O.M.4
Bastidas, N.5
Kleinman, M.E.6
-
23
-
-
3042823868
-
The prognostic significance of phosphatidylinositol 3-kinase pathway activation in human gliomas
-
Chakravarti A, Zhai G, Suzuki Y, Sarkesh S, Black PM, Muzikansky A, et al: The prognostic significance of phosphatidylinositol 3-kinase pathway activation in human gliomas. J Clin Oncol 22:1926-1933, 2004
-
(2004)
J Clin Oncol
, vol.22
, pp. 1926-1933
-
-
Chakravarti, A.1
Zhai, G.2
Suzuki, Y.3
Sarkesh, S.4
Black, P.M.5
Muzikansky, A.6
-
24
-
-
0028805059
-
Suppression of growth of renal carcinoma cells by the von Hippel-Lindau tumor suppressor gene
-
Chen F, Kishida T, Duh FM, Renbaum P, Orcutt ML, Schmidt L, et al: Suppression of growth of renal carcinoma cells by the von Hippel-Lindau tumor suppressor gene. Cancer Res 55:4804-4807, 1995
-
(1995)
Cancer Res
, vol.55
, pp. 4804-4807
-
-
Chen, F.1
Kishida, T.2
Duh, F.M.3
Renbaum, P.4
Orcutt, M.L.5
Schmidt, L.6
-
25
-
-
84864717408
-
VHL regulates the effects of miR-23b on glioma survival and invasion via suppression of HIF-1a/VEGF and b-catenin/Tcf-4 signaling
-
Chen L, Han L, Zhang K, Shi Z, Zhang J, Zhang A, et al: VHL regulates the effects of miR-23b on glioma survival and invasion via suppression of HIF-1a/VEGF and b-catenin/Tcf-4 signaling. Neuro Oncol 14:1026-1036, 2012
-
(2012)
Neuro Oncol
, vol.14
, pp. 1026-1036
-
-
Chen, L.1
Han, L.2
Zhang, K.3
Shi, Z.4
Zhang, J.5
Zhang, A.6
-
26
-
-
61349201437
-
In vitro angiogenesis by human umbilical vein endothelial cells (HUVEC) induced by three-dimensional co-culture with glioblastoma cells
-
Chen Z, Htay A, Dos Santos W, Gillies GT, Fillmore HL, Sholley MM, et al: In vitro angiogenesis by human umbilical vein endothelial cells (HUVEC) induced by three-dimensional co-culture with glioblastoma cells. J Neurooncol 92:121-128, 2009
-
(2009)
J Neurooncol
, vol.92
, pp. 121-128
-
-
Chen, Z.1
Htay, A.2
Dos Santos, W.3
Gillies, G.T.4
Fillmore, H.L.5
Sholley, M.M.6
-
27
-
-
84899415660
-
Lactate dehydrogenase A silencing in IDH mutant gliomas
-
Chesnelong C, Chaumeil MM, Blough MD, Al-Najjar M, Stechishin OD, Chan JA, et al: Lactate dehydrogenase A silencing in IDH mutant gliomas. Neuro Oncol 16:686-695, 2014
-
(2014)
Neuro Oncol
, vol.16
, pp. 686-695
-
-
Chesnelong, C.1
Chaumeil, M.M.2
Blough, M.D.3
Al-Najjar, M.4
Stechishin, O.D.5
Chan, J.A.6
-
28
-
-
77956399348
-
HIF1-alpha functions as a tumor promoter in cancer associated fibroblasts, and as a tumor suppressor in breast cancer cells: autophagy drives compartment-specific oncogenesis
-
Chiavarina B, Whitaker-Menezes D, Migneco G, Martinez-Outschoorn UE, Pavlides S, Howell A, et al: HIF1-alpha functions as a tumor promoter in cancer associated fibroblasts, and as a tumor suppressor in breast cancer cells: autophagy drives compartment-specific oncogenesis. Cell Cycle 9:3534-3551, 2010
-
(2010)
Cell Cycle
, vol.9
, pp. 3534-3551
-
-
Chiavarina, B.1
Whitaker-Menezes, D.2
Migneco, G.3
Martinez-Outschoorn, U.E.4
Pavlides, S.5
Howell, A.6
-
29
-
-
84894231936
-
A ROS/STAT3/HIF-1a signaling cascade mediates EGFinduced TWIST1 expression and prostate cancer cell invasion
-
Cho KH, Choi MJ, Jeong KJ, Kim JJ, Hwang MH, Shin SC, et al: A ROS/STAT3/HIF-1a signaling cascade mediates EGFinduced TWIST1 expression and prostate cancer cell invasion. Prostate 74:528-536, 2014
-
(2014)
Prostate
, vol.74
, pp. 528-536
-
-
Cho, K.H.1
Choi, M.J.2
Jeong, K.J.3
Kim, J.J.4
Hwang, M.H.5
Shin, S.C.6
-
30
-
-
0038615946
-
Analysis of the phosphatidylinositol 3'-kinase signaling pathway in glioblastoma patients in vivo
-
Choe G, Horvath S, Cloughesy TF, Crosby K, Seligson D, Palotie A, et al: Analysis of the phosphatidylinositol 3'-kinase signaling pathway in glioblastoma patients in vivo. Cancer Res 63:2742-2746, 2003
-
(2003)
Cancer Res
, vol.63
, pp. 2742-2746
-
-
Choe, G.1
Horvath, S.2
Cloughesy, T.F.3
Crosby, K.4
Seligson, D.5
Palotie, A.6
-
31
-
-
79960962234
-
HIF-1a stabilization by mitochondrial ROS promotes Met-dependent invasive growth and vasculogenic mimicry in melanoma cells
-
Comito G, Calvani M, Giannoni E, Bianchini F, Calorini L, Torre E, et al: HIF-1a stabilization by mitochondrial ROS promotes Met-dependent invasive growth and vasculogenic mimicry in melanoma cells. Free Radic Biol Med 51:893-904, 2011
-
(2011)
Free Radic Biol Med
, vol.51
, pp. 893-904
-
-
Comito, G.1
Calvani, M.2
Giannoni, E.3
Bianchini, F.4
Calorini, L.5
Torre, E.6
-
32
-
-
0141618460
-
Glucose transporter-1 (GLUT-1): a potential marker of prognosis in rectal carcinoma?
-
Cooper R, Sarioglu S, Sökmen S, Füzün M, Küpelioglu A, Valentine H, et al: Glucose transporter-1 (GLUT-1): a potential marker of prognosis in rectal carcinoma? Br J Cancer 89:870-876, 2003
-
(2003)
Br J Cancer
, vol.89
, pp. 870-876
-
-
Cooper, R.1
Sarioglu, S.2
Sökmen, S.3
Füzün, M.4
Küpelioglu, A.5
Valentine, H.6
-
33
-
-
0031059664
-
Exposure to hypoxia, glucose starvation and acidosis: effect on invasive capacity of murine tumor cells and correlation with cathepsin (L + B) secretion
-
Cuvier C, Jang A, Hill RP: Exposure to hypoxia, glucose starvation and acidosis: effect on invasive capacity of murine tumor cells and correlation with cathepsin (L + B) secretion. Clin Exp Metastasis 15:19-25, 1997
-
(1997)
Clin Exp Metastasis
, vol.15
, pp. 19-25
-
-
Cuvier, C.1
Jang, A.2
Hill, R.P.3
-
34
-
-
84922996291
-
ML309: a potent inhibitor of R132H mutant IDH1 capable of reducing 2-hydroxyglutarate production in U87 MG glioblastoma cells
-
Bethesda, MD: National Center for Biotechnology Information, 2010
-
Davis M, Pragani R, Popovici-Muller J, Gross S, Thorne N, Salituro F, et al: ML309: a potent inhibitor of R132H mutant IDH1 capable of reducing 2-hydroxyglutarate production in U87 MG glioblastoma cells, in Probe Reports from the NIH Molecular Libraries Program. Bethesda, MD: National Center for Biotechnology Information, 2010
-
Probe Reports from the NIH Molecular Libraries Program
-
-
Davis, M.1
Pragani, R.2
Popovici-Muller, J.3
Gross, S.4
Thorne, N.5
Salituro, F.6
-
35
-
-
84901020086
-
Biochemical, cellular, and biophysical characterization of a potent inhibitor of mutant isocitrate dehydrogenase IDH1
-
Davis MI, Gross S, Shen M, Straley KS, Pragani R, Lea WA, et al: Biochemical, cellular, and biophysical characterization of a potent inhibitor of mutant isocitrate dehydrogenase IDH1. J Biol Chem 289:13717-13725, 2014
-
(2014)
J Biol Chem
, vol.289
, pp. 13717-13725
-
-
Davis, M.I.1
Gross, S.2
Shen, M.3
Straley, K.S.4
Pragani, R.5
Lea, W.A.6
-
36
-
-
84865712690
-
The MET oncogene is a functional marker of a glioblastoma stem cell subtype
-
De Bacco F, Casanova E, Medico E, Pellegatta S, Orzan F, Albano R, et al: The MET oncogene is a functional marker of a glioblastoma stem cell subtype. Cancer Res 72:4537-4550, 2012
-
(2012)
Cancer Res
, vol.72
, pp. 4537-4550
-
-
De Bacco, F.1
Casanova, E.2
Medico, E.3
Pellegatta, S.4
Orzan, F.5
Albano, R.6
-
37
-
-
9444226473
-
SDF-1 involvement in endothelial phenotype and ischemia-induced recruitment of bone marrow progenitor cells
-
De Falco E, Porcelli D, Torella AR, Straino S, Iachininoto MG, Orlandi A, et al: SDF-1 involvement in endothelial phenotype and ischemia-induced recruitment of bone marrow progenitor cells. Blood 104:3472-3482, 2004
-
(2004)
Blood
, vol.104
, pp. 3472-3482
-
-
De Falco, E.1
Porcelli, D.2
Torella, A.R.3
Straino, S.4
Iachininoto, M.G.5
Orlandi, A.6
-
38
-
-
33745242315
-
Antiangiogenic potential of the Mammalian target of rapamycin inhibitor temsirolimus
-
Del Bufalo D, Ciuffreda L, Trisciuoglio D, Desideri M, Cognetti F, Zupi G, et al: Antiangiogenic potential of the Mammalian target of rapamycin inhibitor temsirolimus. Cancer Res 66:5549-5554, 2006
-
(2006)
Cancer Res
, vol.66
, pp. 5549-5554
-
-
Del Bufalo, D.1
Ciuffreda, L.2
Trisciuoglio, D.3
Desideri, M.4
Cognetti, F.5
Zupi, G.6
-
39
-
-
39849102836
-
HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion
-
Du R, Lu KV, Petritsch C, Liu P, Ganss R, Passegué E, et al: HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell 13:206-220, 2008
-
(2008)
Cancer Cell
, vol.13
, pp. 206-220
-
-
Du, R.1
Lu, K.V.2
Petritsch, C.3
Liu, P.4
Ganss, R.5
Passegué, E.6
-
40
-
-
84875395513
-
Antitumor activity of dichloroacetate on C6 glioma cell: in vitro and in vivo evaluation
-
Duan Y, Zhao X, Ren W, Wang X, Yu KF, Li D, et al: Antitumor activity of dichloroacetate on C6 glioma cell: in vitro and in vivo evaluation. Onco Targets Ther 6:189-198, 2013
-
(2013)
Onco Targets Ther
, vol.6
, pp. 189-198
-
-
Duan, Y.1
Zhao, X.2
Ren, W.3
Wang, X.4
Yu, K.F.5
Li, D.6
-
41
-
-
34250340883
-
Hypoxia can induce c-Met expression in glioma cells and enhance SF/HGF-induced cell migration
-
Eckerich C, Zapf S, Fillbrandt R, Loges S, Westphal M, Lamszus K: Hypoxia can induce c-Met expression in glioma cells and enhance SF/HGF-induced cell migration. Int J Cancer 121:276-283, 2007
-
(2007)
Int J Cancer
, vol.121
, pp. 276-283
-
-
Eckerich, C.1
Zapf, S.2
Fillbrandt, R.3
Loges, S.4
Westphal, M.5
Lamszus, K.6
-
42
-
-
83555168279
-
D-amino acid oxidase gene therapy sensitizes glioma cells to the antiglycolytic effect of 3-bromopyruvate
-
El Sayed SM, Abou El-Magd RM, Shishido Y, Chung SP, Sakai T, Watanabe H, et al: D-amino acid oxidase gene therapy sensitizes glioma cells to the antiglycolytic effect of 3-bromopyruvate. Cancer Gene Ther 19:1-18, 2012
-
(2012)
Cancer Gene Ther
, vol.19
, pp. 1-18
-
-
El Sayed, S.M.1
Abou El-Magd, R.M.2
Shishido, Y.3
Chung, S.P.4
Sakai, T.5
Watanabe, H.6
-
43
-
-
84858749705
-
3-Bromopyruvate antagonizes effects of lactate and pyruvate, synergizes with citrate and exerts novel antiglioma effects
-
El Sayed SM, El-Magd RM, Shishido Y, Chung SP, Diem TH, Sakai T, et al: 3-Bromopyruvate antagonizes effects of lactate and pyruvate, synergizes with citrate and exerts novel antiglioma effects. J Bioenerg Biomembr 44:61-79, 2012
-
(2012)
J Bioenerg Biomembr
, vol.44
, pp. 61-79
-
-
El Sayed, S.M.1
El-Magd, R.M.2
Shishido, Y.3
Chung, S.P.4
Diem, T.H.5
Sakai, T.6
-
44
-
-
84866645248
-
D-Amino acid oxidase-induced oxidative stress, 3-bromopyruvate and citrate inhibit angiogenesis, exhibiting potent anticancer effects
-
El Sayed SM, El-Magd RM, Shishido Y, Yorita K, Chung SP, Tran DH, et al: D-Amino acid oxidase-induced oxidative stress, 3-bromopyruvate and citrate inhibit angiogenesis, exhibiting potent anticancer effects. J Bioenerg Biomembr 44:513-523, 2012
-
(2012)
J Bioenerg Biomembr
, vol.44
, pp. 513-523
-
-
El Sayed, S.M.1
El-Magd, R.M.2
Shishido, Y.3
Yorita, K.4
Chung, S.P.5
Tran, D.H.6
-
45
-
-
37249067628
-
Glut-1 as a therapeutic target: increased chemoresistance and HIF-1-independent link with cell turnover is revealed through COMPARE analysis and metabolomic studies
-
Evans A, Bates V, Troy H, Hewitt S, Holbeck S, Chung YL, et al: Glut-1 as a therapeutic target: increased chemoresistance and HIF-1-independent link with cell turnover is revealed through COMPARE analysis and metabolomic studies. Cancer Chemother Pharmacol 61:377-393, 2008
-
(2008)
Cancer Chemother Pharmacol
, vol.61
, pp. 377-393
-
-
Evans, A.1
Bates, V.2
Troy, H.3
Hewitt, S.4
Holbeck, S.5
Chung, Y.L.6
-
46
-
-
45549093647
-
Survival of the fittest: cancer stem cells in therapeutic resistance and angiogenesis
-
Eyler CE, Rich JN: Survival of the fittest: cancer stem cells in therapeutic resistance and angiogenesis. J Clin Oncol 26:2839-2845, 2008
-
(2008)
J Clin Oncol
, vol.26
, pp. 2839-2845
-
-
Eyler, C.E.1
Rich, J.N.2
-
47
-
-
33947721693
-
Glioma cells suppress hypoxia-induced endothelial cell apoptosis and promote the angiogenic process
-
Ezhilarasan R, Mohanam I, Govindarajan K, Mohanam S: Glioma cells suppress hypoxia-induced endothelial cell apoptosis and promote the angiogenic process. Int J Oncol 30:701-707, 2007
-
(2007)
Int J Oncol
, vol.30
, pp. 701-707
-
-
Ezhilarasan, R.1
Mohanam, I.2
Govindarajan, K.3
Mohanam, S.4
-
48
-
-
14644432362
-
Apigenin inhibits VEGF and HIF-1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways
-
Fang J, Xia C, Cao Z, Zheng JZ, Reed E, Jiang BH: Apigenin inhibits VEGF and HIF-1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways. FASEB J 19:342-353, 2005
-
(2005)
FASEB J
, vol.19
, pp. 342-353
-
-
Fang, J.1
Xia, C.2
Cao, Z.3
Zheng, J.Z.4
Reed, E.5
Jiang, B.H.6
-
49
-
-
52049107208
-
Hypoxia-regulated protein expression, patient characteristics, and preoperative imaging as predictors of survival in adults with glioblastoma multiforme
-
Flynn JR, Wang L, Gillespie DL, Stoddard GJ, Reid JK, Owens J, et al: Hypoxia-regulated protein expression, patient characteristics, and preoperative imaging as predictors of survival in adults with glioblastoma multiforme. Cancer 113:1032-1042, 2008
-
(2008)
Cancer
, vol.113
, pp. 1032-1042
-
-
Flynn, J.R.1
Wang, L.2
Gillespie, D.L.3
Stoddard, G.J.4
Reid, J.K.5
Owens, J.6
-
50
-
-
70349747011
-
Glioma tumor stem-like cells promote tumor angiogenesis and vasculogenesis via vascular endothelial growth factor and stromal-derived factor 1
-
Folkins C, Shaked Y, Man S, Tang T, Lee CR, Zhu Z, et al: Glioma tumor stem-like cells promote tumor angiogenesis and vasculogenesis via vascular endothelial growth factor and stromal-derived factor 1. Cancer Res 69:7243-7251, 2009
-
(2009)
Cancer Res
, vol.69
, pp. 7243-7251
-
-
Folkins, C.1
Shaked, Y.2
Man, S.3
Tang, T.4
Lee, C.R.5
Zhu, Z.6
-
51
-
-
0029761644
-
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
-
Forsythe JA, Jiang BH, Iyer NV, Agani F, Leung SW, Koos RD, et al: Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol 16:4604-4613, 1996
-
(1996)
Mol Cell Biol
, vol.16
, pp. 4604-4613
-
-
Forsythe, J.A.1
Jiang, B.H.2
Iyer, N.V.3
Agani, F.4
Leung, S.W.5
Koos, R.D.6
-
52
-
-
75849160216
-
Human cancers converge at the HIF-2alpha oncogenic axis
-
Franovic A, Holterman CE, Payette J, Lee S: Human cancers converge at the HIF-2alpha oncogenic axis. Proc Natl Acad Sci U S A 106:21306-21311, 2009
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 21306-21311
-
-
Franovic, A.1
Holterman, C.E.2
Payette, J.3
Lee, S.4
-
53
-
-
35848959917
-
Akt inhibitor shows anticancer and radiosensitizing effects in malignant glioma cells by inducing autophagy
-
Fujiwara K, Iwado E, Mills GB, Sawaya R, Kondo S, Kondo Y: Akt inhibitor shows anticancer and radiosensitizing effects in malignant glioma cells by inducing autophagy. Int J Oncol 31:753-760, 2007
-
(2007)
Int J Oncol
, vol.31
, pp. 753-760
-
-
Fujiwara, K.1
Iwado, E.2
Mills, G.B.3
Sawaya, R.4
Kondo, S.5
Kondo, Y.6
-
54
-
-
34247847903
-
Silencing hypoxia-inducible factor-1alpha inhibits cell migration and invasion under hypoxic environment in malignant gliomas
-
Fujiwara S, Nakagawa K, Harada H, Nagato S, Furukawa K, Teraoka M, et al: Silencing hypoxia-inducible factor-1alpha inhibits cell migration and invasion under hypoxic environment in malignant gliomas. Int J Oncol 30:793-802, 2007
-
(2007)
Int J Oncol
, vol.30
, pp. 793-802
-
-
Fujiwara, S.1
Nakagawa, K.2
Harada, H.3
Nagato, S.4
Furukawa, K.5
Teraoka, M.6
-
55
-
-
0031892776
-
Microsatellite deletion mapping on chromosome 10q and mutation analysis of MMAC1, FAS, and MXI1 in human glioblastoma multiforme
-
Fults D, Pedone CA, Thompson GE, Uchiyama CM, Gumpper KL, Iliev D, et al: Microsatellite deletion mapping on chromosome 10q and mutation analysis of MMAC1, FAS, and MXI1 in human glioblastoma multiforme. Int J Oncol 12:905-910, 1998
-
(1998)
Int J Oncol
, vol.12
, pp. 905-910
-
-
Fults, D.1
Pedone, C.A.2
Thompson, G.E.3
Uchiyama, C.M.4
Gumpper, K.L.5
Iliev, D.6
-
56
-
-
84895863876
-
Molecular analysis of a recurrent glioblastoma treated with bevacizumab
-
Furuta T, Nakada M, Misaki K, Sato Y, Hayashi Y, Nakanuma Y, et al: Molecular analysis of a recurrent glioblastoma treated with bevacizumab. Brain Tumor Pathol 31:32-39, 2014
-
(2014)
Brain Tumor Pathol
, vol.31
, pp. 32-39
-
-
Furuta, T.1
Nakada, M.2
Misaki, K.3
Sato, Y.4
Hayashi, Y.5
Nakanuma, Y.6
-
58
-
-
77952219448
-
Mechanistic evaluation of the novel HSP90 inhibitor NVP-AUY922 in adult and pediatric glioblastoma
-
Gaspar N, Sharp SY, Eccles SA, Gowan S, Popov S, Jones C, et al: Mechanistic evaluation of the novel HSP90 inhibitor NVP-AUY922 in adult and pediatric glioblastoma. Mol Cancer Ther 9:1219-1233, 2010
-
(2010)
Mol Cancer Ther
, vol.9
, pp. 1219-1233
-
-
Gaspar, N.1
Sharp, S.Y.2
Eccles, S.A.3
Gowan, S.4
Popov, S.5
Jones, C.6
-
59
-
-
0023932431
-
Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy
-
Gatenby RA, Kessler HB, Rosenblum JS, Coia LR, Moldofsky PJ, Hartz WH, et al: Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy. Int J Radiat Oncol Biol Phys 14:831-838, 1988
-
(1988)
Int J Radiat Oncol Biol Phys
, vol.14
, pp. 831-838
-
-
Gatenby, R.A.1
Kessler, H.B.2
Rosenblum, J.S.3
Coia, L.R.4
Moldofsky, P.J.5
Hartz, W.H.6
-
60
-
-
84916933180
-
RNA interference targeting HIF-1a via a novel multifunctional surfactant attenuates glioma growth in an intracranial mouse model
-
[in press]
-
Gillespie D, Arce-Larreta M, Ravichandran S, Leishman L, Berrondo C, Gamboa J, et al: RNA interference targeting HIF-1a via a novel multifunctional surfactant attenuates glioma growth in an intracranial mouse model. J Neurosurg [in press]
-
J Neurosurg
-
-
Gillespie, D.1
Arce-Larreta, M.2
Ravichandran, S.3
Leishman, L.4
Berrondo, C.5
Gamboa, J.6
-
61
-
-
34247847910
-
Silencing of hypoxia inducible factor-1alpha by RNA interference attenuates human glioma cell growth in vivo
-
Gillespie DL, Whang K, Ragel BT, Flynn JR, Kelly DA, Jensen RL: Silencing of hypoxia inducible factor-1alpha by RNA interference attenuates human glioma cell growth in vivo. Clin Cancer Res 13:2441-2448, 2007
-
(2007)
Clin Cancer Res
, vol.13
, pp. 2441-2448
-
-
Gillespie, D.L.1
Whang, K.2
Ragel, B.T.3
Flynn, J.R.4
Kelly, D.A.5
Jensen, R.L.6
-
62
-
-
0029785838
-
Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene
-
Gnarra JR, Zhou S, Merrill MJ, Wagner JR, Krumm A, Papavassiliou E, et al: Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene. Proc Natl Acad Sci U S A 93:10589-10594, 1996
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 10589-10594
-
-
Gnarra, J.R.1
Zhou, S.2
Merrill, M.J.3
Wagner, J.R.4
Krumm, A.5
Papavassiliou, E.6
-
63
-
-
0033521864
-
Hypoxia-mediated stimulation of carcinoma cell invasiveness via upregulation of urokinase receptor expression
-
Graham CH, Forsdike J, Fitzgerald CJ, Macdonald-Goodfellow S: Hypoxia-mediated stimulation of carcinoma cell invasiveness via upregulation of urokinase receptor expression. Int J Cancer 80:617-623, 1999
-
(1999)
Int J Cancer
, vol.80
, pp. 617-623
-
-
Graham, C.H.1
Forsdike, J.2
Fitzgerald, C.J.3
Macdonald-Goodfellow, S.4
-
64
-
-
84875911885
-
MiR-210 promotes a hypoxic phenotype and increases radioresistance in human lung cancer cell lines
-
Grosso S, Doyen J, Parks SK, Bertero T, Paye A, Cardinaud B, et al: MiR-210 promotes a hypoxic phenotype and increases radioresistance in human lung cancer cell lines. Cell Death Dis 4:e544, 2013
-
(2013)
Cell Death Dis
, vol.4
-
-
Grosso, S.1
Doyen, J.2
Parks, S.K.3
Bertero, T.4
Paye, A.5
Cardinaud, B.6
-
65
-
-
77950827990
-
An orally bioavailable c-Met kinase inhibitor potently inhibits brain tumor malignancy and growth
-
Guessous F, Zhang Y, diPierro C, Marcinkiewicz L, Sarkaria J, Schiff D, et al: An orally bioavailable c-Met kinase inhibitor potently inhibits brain tumor malignancy and growth. Anticancer Agents Med Chem 10:28-35, 2010
-
(2010)
Anticancer Agents Med Chem
, vol.10
, pp. 28-35
-
-
Guessous, F.1
Zhang, Y.2
diPierro, C.3
Marcinkiewicz, L.4
Sarkaria, J.5
Schiff, D.6
-
66
-
-
84906277818
-
Hypoxia suppresses cylindromatosis (CYLD) expression to promote inflammation in glioblastoma: possible link to acquired resistance to anti-VEGF therapy
-
Guo J, Shinriki S, Su Y, Nakamura T, Hayashi M, Tsuda Y, et al: Hypoxia suppresses cylindromatosis (CYLD) expression to promote inflammation in glioblastoma: possible link to acquired resistance to anti-VEGF therapy. Oncotarget 15:6353-6364, 2014
-
(2014)
Oncotarget
, vol.15
, pp. 6353-6364
-
-
Guo, J.1
Shinriki, S.2
Su, Y.3
Nakamura, T.4
Hayashi, M.5
Tsuda, Y.6
-
67
-
-
33646127170
-
The VHL/HIF oxygen-sensing pathway and its relevance to kidney disease
-
Haase VH: The VHL/HIF oxygen-sensing pathway and its relevance to kidney disease. Kidney Int 69:1302-1307, 2006
-
(2006)
Kidney Int
, vol.69
, pp. 1302-1307
-
-
Haase, V.H.1
-
68
-
-
24744467401
-
Hypoxia-inducible factor 1alpha and antiangiogenic activity of farnesyltransferase inhibitor SCH66336 in human aerodigestive tract cancer
-
Han JY, Oh SH, Morgillo F, Myers JN, Kim E, Hong WK, et al: Hypoxia-inducible factor 1alpha and antiangiogenic activity of farnesyltransferase inhibitor SCH66336 in human aerodigestive tract cancer. J Natl Cancer Inst 97:1272-1286, 2005
-
(2005)
J Natl Cancer Inst
, vol.97
, pp. 1272-1286
-
-
Han, J.Y.1
Oh, S.H.2
Morgillo, F.3
Myers, J.N.4
Kim, E.5
Hong, W.K.6
-
69
-
-
80053355093
-
How can we overcome tumor hypoxia in radiation therapy?
-
Harada H: How can we overcome tumor hypoxia in radiation therapy? J Radiat Res (Tokyo) 52:545-556, 2011
-
(2011)
J Radiat Res (Tokyo)
, vol.52
, pp. 545-556
-
-
Harada, H.1
-
70
-
-
84894265566
-
The effect of HIF-1a on glucose metabolism, growth and apoptosis of pancreatic cancerous cells
-
He G, Jiang Y, Zhang B, Wu G: The effect of HIF-1a on glucose metabolism, growth and apoptosis of pancreatic cancerous cells. Asia Pac J Clin Nutr 23:174-180, 2014
-
(2014)
Asia Pac J Clin Nutr
, vol.23
, pp. 174-180
-
-
He, G.1
Jiang, Y.2
Zhang, B.3
Wu, G.4
-
71
-
-
84890531155
-
Hypoxia-inducible factor pathway inhibition resolves tumor hypoxia and improves local tumor control after single-dose irradiation
-
Helbig L, Koi L, Brüchner K, Gurtner K, Hess-Stumpp H, Unterschemmann K, et al: Hypoxia-inducible factor pathway inhibition resolves tumor hypoxia and improves local tumor control after single-dose irradiation. Int J Radiat Oncol Biol Phys 88:159-166, 2014
-
(2014)
Int J Radiat Oncol Biol Phys
, vol.88
, pp. 159-166
-
-
Helbig, L.1
Koi, L.2
Brüchner, K.3
Gurtner, K.4
Hess-Stumpp, H.5
Unterschemmann, K.6
-
72
-
-
84884672514
-
Exposure to hypoxia following irradiation increases radioresistance in prostate cancer cells
-
Hennessey D, Martin LM, Atzberger A, Lynch TH, Hollywood D, Marignol L: Exposure to hypoxia following irradiation increases radioresistance in prostate cancer cells. Urol Oncol 31:1106-1116, 2013
-
(2013)
Urol Oncol
, vol.31
, pp. 1106-1116
-
-
Hennessey, D.1
Martin, L.M.2
Atzberger, A.3
Lynch, T.H.4
Hollywood, D.5
Marignol, L.6
-
73
-
-
75149165633
-
Prolyl hydroxylases 2 and 3 act in gliomas as protective negative feedback regulators of hypoxia-inducible factors
-
Henze AT, Riedel J, Diem T, Wenner J, Flamme I, Pouyseggur J, et al: Prolyl hydroxylases 2 and 3 act in gliomas as protective negative feedback regulators of hypoxia-inducible factors. Cancer Res 70:357-366, 2010
-
(2010)
Cancer Res
, vol.70
, pp. 357-366
-
-
Henze, A.T.1
Riedel, J.2
Diem, T.3
Wenner, J.4
Flamme, I.5
Pouyseggur, J.6
-
74
-
-
18544386401
-
Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family
-
Hewitson KS, McNeill LA, Riordan MV, Tian YM, Bullock AN, Welford RW, et al: Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family. J Biol Chem 277:26351-26355, 2002
-
(2002)
J Biol Chem
, vol.277
, pp. 26351-26355
-
-
Hewitson, K.S.1
McNeill, L.A.2
Riordan, M.V.3
Tian, Y.M.4
Bullock, A.N.5
Welford, R.W.6
-
75
-
-
84902338069
-
Identification of temozolomide resistance factors in glioblastoma via integrative miRNA/mRNA regulatory network analysis
-
Hiddingh L, Raktoe RS, Jeuken J, Hulleman E, Noske DP, Kaspers GJ, et al: Identification of temozolomide resistance factors in glioblastoma via integrative miRNA/mRNA regulatory network analysis. Sci Rep 4:5260, 2014
-
(2014)
Sci Rep
, vol.4
, pp. 5260
-
-
Hiddingh, L.1
Raktoe, R.S.2
Jeuken, J.3
Hulleman, E.4
Noske, D.P.5
Kaspers, G.J.6
-
76
-
-
0029775242
-
Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix
-
Hockel M, Schlenger K, Aral B, Mitze M, Schaffer U, Vaupel P: Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res 56:4509-4515, 1996
-
(1996)
Cancer Res
, vol.56
, pp. 4509-4515
-
-
Hockel, M.1
Schlenger, K.2
Aral, B.3
Mitze, M.4
Schaffer, U.5
Vaupel, P.6
-
77
-
-
0342857011
-
Tumor hypoxia in pelvic recurrences of cervical cancer
-
Höckel M, Schlenger K, Höckel S, Aral B, Schäffer U, Vaupel P: Tumor hypoxia in pelvic recurrences of cervical cancer. Int J Cancer 79:365-369, 1998
-
(1998)
Int J Cancer
, vol.79
, pp. 365-369
-
-
Höckel, M.1
Schlenger, K.2
Höckel, S.3
Aral, B.4
Schäffer, U.5
Vaupel, P.6
-
78
-
-
84891496217
-
RACK1 promoted the growth and migration of the cancer cells in the progression of esophageal squamous cell carcinoma
-
Hu F, Tao Z, Wang M, Li G, Zhang Y, Zhong H, et al: RACK1 promoted the growth and migration of the cancer cells in the progression of esophageal squamous cell carcinoma. Tumour Biol 34:3893-3899, 2013
-
(2013)
Tumour Biol
, vol.34
, pp. 3893-3899
-
-
Hu, F.1
Tao, Z.2
Wang, M.3
Li, G.4
Zhang, Y.5
Zhong, H.6
-
79
-
-
84859385707
-
Hypoxia-induced autophagy promotes tumor cell survival and adaptation to antiangiogenic treatment in glioblastoma
-
Hu YL, DeLay M, Jahangiri A, Molinaro AM, Rose SD, Carbonell WS, et al: Hypoxia-induced autophagy promotes tumor cell survival and adaptation to antiangiogenic treatment in glioblastoma. Cancer Res 72:1773-1783, 2012
-
(2012)
Cancer Res
, vol.72
, pp. 1773-1783
-
-
Hu, Y.L.1
DeLay, M.2
Jahangiri, A.3
Molinaro, A.M.4
Rose, S.D.5
Carbonell, W.S.6
-
80
-
-
84874005713
-
Targeting Src family kinases inhibits bevacizumab-induced glioma cell invasion
-
Huveldt D, Lewis-Tuffin LJ, Carlson BL, Schroeder MA, Rodriguez F, Giannini C, et al: Targeting Src family kinases inhibits bevacizumab-induced glioma cell invasion. PLoS ONE 8:e56505, 2013
-
(2013)
PLoS ONE
, vol.8
-
-
Huveldt, D.1
Lewis-Tuffin, L.J.2
Carlson, B.L.3
Schroeder, M.A.4
Rodriguez, F.5
Giannini, C.6
-
81
-
-
0031967883
-
Distinct patterns of deletion on 10p and 10q suggest involvement of multiple tumor suppressor genes in the development of astrocytic gliomas of different malignancy grades
-
Ichimura K, Schmidt EE, Miyakawa A, Goike HM, Collins VP: Distinct patterns of deletion on 10p and 10q suggest involvement of multiple tumor suppressor genes in the development of astrocytic gliomas of different malignancy grades. Genes Chromosomes Cancer 22:9-15, 1998
-
(1998)
Genes Chromosomes Cancer
, vol.22
, pp. 9-15
-
-
Ichimura, K.1
Schmidt, E.E.2
Miyakawa, A.3
Goike, H.M.4
Collins, V.P.5
-
82
-
-
33846562017
-
Extracellular acidosis elevates carbonic anhydrase IX in human glioblastoma cells via transcriptional modulation that does not depend on hypoxia
-
Ihnatko R, Kubes M, Takacova M, Sedlakova O, Sedlak J, Pastorek J, et al: Extracellular acidosis elevates carbonic anhydrase IX in human glioblastoma cells via transcriptional modulation that does not depend on hypoxia. Int J Oncol 29:1025-1033, 2006
-
(2006)
Int J Oncol
, vol.29
, pp. 1025-1033
-
-
Ihnatko, R.1
Kubes, M.2
Takacova, M.3
Sedlakova, O.4
Sedlak, J.5
Pastorek, J.6
-
83
-
-
84873735398
-
Arginase II expressed in cancer-associated fibroblasts indicates tissue hypoxia and predicts poor outcome in patients with pancreatic cancer
-
Ino Y, Yamazaki-Itoh R, Oguro S, Shimada K, Kosuge T, Zavada J, et al: Arginase II expressed in cancer-associated fibroblasts indicates tissue hypoxia and predicts poor outcome in patients with pancreatic cancer. PLoS ONE 8:e55146, 2013
-
(2013)
PLoS ONE
, vol.8
-
-
Ino, Y.1
Yamazaki-Itoh, R.2
Oguro, S.3
Shimada, K.4
Kosuge, T.5
Zavada, J.6
-
84
-
-
0037119415
-
Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway
-
Isaacs JS, Jung YJ, Mimnaugh EG, Martinez A, Cuttitta F, Neckers LM: Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway. J Biol Chem 277:29936-29944, 2002
-
(2002)
J Biol Chem
, vol.277
, pp. 29936-29944
-
-
Isaacs, J.S.1
Jung, Y.J.2
Mimnaugh, E.G.3
Martinez, A.4
Cuttitta, F.5
Neckers, L.M.6
-
85
-
-
0035107383
-
Expression of hypoxia-inducible cell-surface transmembrane carbonic anhydrases in human cancer
-
Ivanov S, Liao SY, Ivanova A, Danilkovitch-Miagkova A, Tarasova N, Weirich G, et al: Expression of hypoxia-inducible cell-surface transmembrane carbonic anhydrases in human cancer. Am J Pathol 158:905-919, 2001
-
(2001)
Am J Pathol
, vol.158
, pp. 905-919
-
-
Ivanov, S.1
Liao, S.Y.2
Ivanova, A.3
Danilkovitch-Miagkova, A.4
Tarasova, N.5
Weirich, G.6
-
86
-
-
84877098516
-
Gene expression profile identifies tyrosine kinase c-Met as a targetable mediator of antiangiogenic therapy resistance
-
Jahangiri A, De Lay M, Miller LM, Carbonell WS, Hu YL, Lu K, et al: Gene expression profile identifies tyrosine kinase c-Met as a targetable mediator of antiangiogenic therapy resistance. Clin Cancer Res 19:1773-1783, 2013
-
(2013)
Clin Cancer Res
, vol.19
, pp. 1773-1783
-
-
Jahangiri, A.1
De Lay, M.2
Miller, L.M.3
Carbonell, W.S.4
Hu, Y.L.5
Lu, K.6
-
87
-
-
33744828248
-
Glucose withdrawal induces oxidative stress followed by apoptosis in glioblastoma cells but not in normal human astrocytes
-
Jelluma N, Yang X, Stokoe D, Evan GI, Dansen TB, Haas-Kogan DA: Glucose withdrawal induces oxidative stress followed by apoptosis in glioblastoma cells but not in normal human astrocytes. Mol Cancer Res 4:319-330, 2006
-
(2006)
Mol Cancer Res
, vol.4
, pp. 319-330
-
-
Jelluma, N.1
Yang, X.2
Stokoe, D.3
Evan, G.I.4
Dansen, T.B.5
Haas-Kogan, D.A.6
-
88
-
-
65249131228
-
Brain tumor hypoxia: tumorigenesis, angiogenesis, imaging, pseudoprogression, and as a therapeutic target
-
Jensen RL: Brain tumor hypoxia: tumorigenesis, angiogenesis, imaging, pseudoprogression, and as a therapeutic target. J Neurooncol 92:317-335, 2009
-
(2009)
J Neurooncol
, vol.92
, pp. 317-335
-
-
Jensen, R.L.1
-
89
-
-
33747178432
-
Hypoxia in the tumorigenesis of gliomas and as a potential target for therapeutic measures
-
Jensen RL: Hypoxia in the tumorigenesis of gliomas and as a potential target for therapeutic measures. Neurosurg Focus 20(4):E24, 2006
-
(2006)
Neurosurg Focus
, vol.20
, Issue.4
-
-
Jensen, R.L.1
-
90
-
-
18744375998
-
Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation
-
Jeong JW, Bae MK, Ahn MY, Kim SH, Sohn TK, Bae MH, et al: Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation. Cell 111:709-720, 2002
-
(2002)
Cell
, vol.111
, pp. 709-720
-
-
Jeong, J.W.1
Bae, M.K.2
Ahn, M.Y.3
Kim, S.H.4
Sohn, T.K.5
Bae, M.H.6
-
91
-
-
84916883938
-
Pyruvate dehydrogenase kinase as a potential therapeutic target for malignant gliomas
-
Jha MK, Suk K: Pyruvate dehydrogenase kinase as a potential therapeutic target for malignant gliomas. Brain Tumor Res Treat 1:57-63, 2013
-
(2013)
Brain Tumor Res Treat
, vol.1
, pp. 57-63
-
-
Jha, M.K.1
Suk, K.2
-
92
-
-
80054006821
-
Noscapine inhibits tumor growth in TMZ-resistant gliomas
-
Jhaveri N, Cho H, Torres S, Wang W, Schönthal AH, Petasis NA, et al: Noscapine inhibits tumor growth in TMZ-resistant gliomas. Cancer Lett 312:245-252, 2011
-
(2011)
Cancer Lett
, vol.312
, pp. 245-252
-
-
Jhaveri, N.1
Cho, H.2
Torres, S.3
Wang, W.4
Schönthal, A.H.5
Petasis, N.A.6
-
93
-
-
0029944965
-
Dimerization, DNA binding, and transactivation properties of hypoxiainducible factor 1
-
Jiang BH, Rue E, Wang GL, Roe R, Semenza GL: Dimerization, DNA binding, and transactivation properties of hypoxiainducible factor 1. J Biol Chem 271:17771-17778, 1996
-
(1996)
J Biol Chem
, vol.271
, pp. 17771-17778
-
-
Jiang, B.H.1
Rue, E.2
Wang, G.L.3
Roe, R.4
Semenza, G.L.5
-
94
-
-
84555220669
-
In vivo specific delivery of c-Met siRNA to glioblastoma using cationic solid lipid nanoparticles
-
Jin J, Bae KH, Yang H, Lee SJ, Kim H, Kim Y, et al: In vivo specific delivery of c-Met siRNA to glioblastoma using cationic solid lipid nanoparticles. Bioconjug Chem 22:2568-2572, 2011
-
(2011)
Bioconjug Chem
, vol.22
, pp. 2568-2572
-
-
Jin, J.1
Bae, K.H.2
Yang, H.3
Lee, S.J.4
Kim, H.5
Kim, Y.6
-
95
-
-
84864863728
-
MET signaling regulates glioblastoma stem cells
-
Joo KM, Jin J, Kim E, Ho Kim K, Kim Y, Gu Kang B, et al: MET signaling regulates glioblastoma stem cells. Cancer Res 72:3828-3838, 2012
-
(2012)
Cancer Res
, vol.72
, pp. 3828-3838
-
-
Joo, K.M.1
Jin, J.2
Kim, E.3
Ho Kim, K.4
Kim, Y.5
Gu Kang, B.6
-
96
-
-
84894579110
-
Inhibition of EGFR induces a c-MET-driven stem cell population in glioblastoma
-
Jun HJ, Bronson RT, Charest A: Inhibition of EGFR induces a c-MET-driven stem cell population in glioblastoma. Stem Cells 32:338-348, 2014
-
(2014)
Stem Cells
, vol.32
, pp. 338-348
-
-
Jun, H.J.1
Bronson, R.T.2
Charest, A.3
-
97
-
-
36749042647
-
AMG 102, a fully human anti-hepatocyte growth factor/scatter factor neutralizing antibody, enhances the efficacy of temozolomide or docetaxel in U-87 MG cells and xenografts
-
Jun HT, Sun J, Rex K, Radinsky R, Kendall R, Coxon A, et al: AMG 102, a fully human anti-hepatocyte growth factor/scatter factor neutralizing antibody, enhances the efficacy of temozolomide or docetaxel in U-87 MG cells and xenografts. Clin Cancer Res 13:6735-6742, 2007
-
(2007)
Clin Cancer Res
, vol.13
, pp. 6735-6742
-
-
Jun, H.T.1
Sun, J.2
Rex, K.3
Radinsky, R.4
Kendall, R.5
Coxon, A.6
-
98
-
-
0036718539
-
Molecular basis of the VHL hereditary cancer syndrome
-
Kaelin WG Jr: Molecular basis of the VHL hereditary cancer syndrome. Nat Rev Cancer 2:673-682, 2002
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 673-682
-
-
Kaelin Jr, W.G.1
-
99
-
-
33746496671
-
Proteasomal inhibition attenuates transcriptional activity of hypoxia-inducible factor 1 (HIF-1) via specific effect on the HIF-1alpha C-terminal activation domain
-
Kaluz S, Kaluzová M, Stanbridge EJ: Proteasomal inhibition attenuates transcriptional activity of hypoxia-inducible factor 1 (HIF-1) via specific effect on the HIF-1alpha C-terminal activation domain. Mol Cell Biol 26:5895-5907, 2006
-
(2006)
Mol Cell Biol
, vol.26
, pp. 5895-5907
-
-
Kaluz, S.1
Kaluzová, M.2
Stanbridge, E.J.3
-
100
-
-
79951679423
-
At the crossroads of cancer and inflammation: Ras rewires an HIF-driven IL-1 autocrine loop
-
Kaluz S, Van Meir EG: At the crossroads of cancer and inflammation: Ras rewires an HIF-driven IL-1 autocrine loop. J Mol Med (Berl) 89:91-94, 2011
-
(2011)
J Mol Med (Berl)
, vol.89
, pp. 91-94
-
-
Kaluz, S.1
Van Meir, E.G.2
-
101
-
-
84873625209
-
The VHL tumor suppressor protein regulates tumorigenicity of U87-derived glioma stem-like cells by inhibiting the JAK/STAT signaling pathway
-
Kanno H, Sato H, Yokoyama TA, Yoshizumi T, Yamada S: The VHL tumor suppressor protein regulates tumorigenicity of U87-derived glioma stem-like cells by inhibiting the JAK/STAT signaling pathway. Int J Oncol 42:881-886, 2013
-
(2013)
Int J Oncol
, vol.42
, pp. 881-886
-
-
Kanno, H.1
Sato, H.2
Yokoyama, T.A.3
Yoshizumi, T.4
Yamada, S.5
-
102
-
-
17844371306
-
Hypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis
-
Kaur B, Khwaja FW, Severson EA, Matheny SL, Brat DJ, Van Meir EG: Hypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis. Neuro Oncol 7:134-153, 2005
-
(2005)
Neuro Oncol
, vol.7
, pp. 134-153
-
-
Kaur, B.1
Khwaja, F.W.2
Severson, E.A.3
Matheny, S.L.4
Brat, D.J.5
Van Meir, E.G.6
-
103
-
-
84655161946
-
HIF1a and HIF2a: sibling rivalry in hypoxic tumour growth and progression
-
Keith B, Johnson RS, Simon MC: HIF1a and HIF2a: sibling rivalry in hypoxic tumour growth and progression. Nat Rev Cancer 12:9-22, 2012
-
(2012)
Nat Rev Cancer
, vol.12
, pp. 9-22
-
-
Keith, B.1
Johnson, R.S.2
Simon, M.C.3
-
104
-
-
78049404785
-
HIF-1a inhibition by siRNA or chetomin in human malignant glioma cells: effects on hypoxic radioresistance and monitoring via CA9 expression
-
Kessler J, Hahnel A, Wichmann H, Rot S, Kappler M, Bache M, et al: HIF-1a inhibition by siRNA or chetomin in human malignant glioma cells: effects on hypoxic radioresistance and monitoring via CA9 expression. BMC Cancer 10:605, 2010
-
(2010)
BMC Cancer
, vol.10
, pp. 605
-
-
Kessler, J.1
Hahnel, A.2
Wichmann, H.3
Rot, S.4
Kappler, M.5
Bache, M.6
-
105
-
-
79952740612
-
Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma
-
Keunen O, Johansson M, Oudin A, Sanzey M, Rahim SA, Fack F, et al: Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma. Proc Natl Acad Sci U S A 108:3749-3754, 2011
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 3749-3754
-
-
Keunen, O.1
Johansson, M.2
Oudin, A.3
Sanzey, M.4
Rahim, S.A.5
Fack, F.6
-
106
-
-
0036708853
-
Signaling cross-talk between hypoxia and glucose via hypoxia-inducible factor 1 and glucose response elements
-
Kietzmann T, Krones-Herzig A, Jungermann K: Signaling cross-talk between hypoxia and glucose via hypoxia-inducible factor 1 and glucose response elements. Biochem Pharmacol 64:903-911, 2002
-
(2002)
Biochem Pharmacol
, vol.64
, pp. 903-911
-
-
Kietzmann, T.1
Krones-Herzig, A.2
Jungermann, K.3
-
107
-
-
33644769210
-
Systemic anti-hepatocyte growth factor monoclonal antibody therapy induces the regression of intracranial glioma xenografts
-
Kim KJ, Wang L, Su YC, Gillespie GY, Salhotra A, Lal B, et al: Systemic anti-hepatocyte growth factor monoclonal antibody therapy induces the regression of intracranial glioma xenografts. Clin Cancer Res 12:1292-1298, 2006
-
(2006)
Clin Cancer Res
, vol.12
, pp. 1292-1298
-
-
Kim, K.J.1
Wang, L.2
Su, Y.C.3
Gillespie, G.Y.4
Salhotra, A.5
Lal, B.6
-
108
-
-
0033975850
-
Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: control of hypoxia-inducible factor-1 activity by nitric oxide
-
Kimura H, Weisz A, Kurashima Y, Hashimoto K, Ogura T, D'Acquisto F, et al: Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: control of hypoxia-inducible factor-1 activity by nitric oxide. Blood 95:189-197, 2000
-
(2000)
Blood
, vol.95
, pp. 189-197
-
-
Kimura, H.1
Weisz, A.2
Kurashima, Y.3
Hashimoto, K.4
Ogura, T.5
D'Acquisto, F.6
-
109
-
-
84865429409
-
Passing the baton: the HIF switch
-
Koh MY, Powis G: Passing the baton: the HIF switch. Trends Biochem Sci 37:364-372, 2012
-
(2012)
Trends Biochem Sci
, vol.37
, pp. 364-372
-
-
Koh, M.Y.1
Powis, G.2
-
110
-
-
84862776918
-
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
-
Koivunen P, Lee S, Duncan CG, Lopez G, Lu G, Ramkissoon S, et al: Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation. Nature 483:484-488, 2012
-
(2012)
Nature
, vol.483
, pp. 484-488
-
-
Koivunen, P.1
Lee, S.2
Duncan, C.G.3
Lopez, G.4
Lu, G.5
Ramkissoon, S.6
-
111
-
-
0036528246
-
Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein
-
Kondo K, Klco J, Nakamura E, Lechpammer M, Kaelin WG Jr: Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein. Cancer Cell 1:237-246, 2002
-
(2002)
Cancer Cell
, vol.1
, pp. 237-246
-
-
Kondo, K.1
Klco, J.2
Nakamura, E.3
Lechpammer, M.4
Kaelin Jr, W.G.5
-
112
-
-
52149096024
-
PTEN signaling pathways in glioblastoma
-
Koul D: PTEN signaling pathways in glioblastoma. Cancer Biol Ther 7:1321-1325, 2008
-
(2008)
Cancer Biol Ther
, vol.7
, pp. 1321-1325
-
-
Koul, D.1
-
113
-
-
0034676331
-
Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function
-
Krieg M, Haas R, Brauch H, Acker T, Flamme I, Plate KH: Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function. Oncogene 19:5435-5443, 2000
-
(2000)
Oncogene
, vol.19
, pp. 5435-5443
-
-
Krieg, M.1
Haas, R.2
Brauch, H.3
Acker, T.4
Flamme, I.5
Plate, K.H.6
-
114
-
-
84878620894
-
Dichloroacetate reverses the hypoxic adaptation to bevacizumab and enhances its antitumor effects in mouse xenografts
-
Kumar K, Wigfield S, Gee HE, Devlin CM, Singleton D, Li JL, et al: Dichloroacetate reverses the hypoxic adaptation to bevacizumab and enhances its antitumor effects in mouse xenografts. J Mol Med (Berl) 91:749-758, 2013
-
(2013)
J Mol Med (Berl)
, vol.91
, pp. 749-758
-
-
Kumar, K.1
Wigfield, S.2
Gee, H.E.3
Devlin, C.M.4
Singleton, D.5
Li, J.L.6
-
115
-
-
84911946922
-
Neovascularization in glioblastoma: current pitfall in anti-angiogenic therapy
-
Kumar S, Arbab AS: Neovascularization in glioblastoma: current pitfall in anti-angiogenic therapy. Zhong Liu Za Zhi 1:16-19, 2013
-
(2013)
Zhong Liu Za Zhi
, vol.1
, pp. 16-19
-
-
Kumar, S.1
Arbab, A.S.2
-
116
-
-
84864412437
-
Inhibition of VEGF transcription through blockade of the hypoxia inducible factor-1a-p300 interaction by a small molecule
-
Kwon HS, Kim DR, Yang EG, Park YK, Ahn HC, Min SJ, et al: Inhibition of VEGF transcription through blockade of the hypoxia inducible factor-1a-p300 interaction by a small molecule. Bioorg Med Chem Lett 22:5249-5252, 2012
-
(2012)
Bioorg Med Chem Lett
, vol.22
, pp. 5249-5252
-
-
Kwon, H.S.1
Kim, D.R.2
Yang, E.G.3
Park, Y.K.4
Ahn, H.C.5
Min, S.J.6
-
117
-
-
0035812284
-
Transcriptional response to hypoxia in human tumors
-
Lal A, Peters H, St Croix B, Haroon ZA, Dewhirst MW, Strausberg RL, et al: Transcriptional response to hypoxia in human tumors. J Natl Cancer Inst 93:1337-1343, 2001
-
(2001)
J Natl Cancer Inst
, vol.93
, pp. 1337-1343
-
-
Lal, A.1
Peters, H.2
St Croix, B.3
Haroon, Z.A.4
Dewhirst, M.W.5
Strausberg, R.L.6
-
118
-
-
20444467263
-
Targeting the c-Met pathway potentiates glioblastoma responses to gamma-radiation
-
Lal B, Xia S, Abounader R, Laterra J: Targeting the c-Met pathway potentiates glioblastoma responses to gamma-radiation. Clin Cancer Res 11:4479-4486, 2005
-
(2005)
Clin Cancer Res
, vol.11
, pp. 4479-4486
-
-
Lal, B.1
Xia, S.2
Abounader, R.3
Laterra, J.4
-
119
-
-
48949095975
-
Significant antitumor activity in vivo following treatment with the microtubule agent ENMD-1198
-
LaVallee TM, Burke PA, Swartz GM, Hamel E, Agoston GE, Shah J, et al: Significant antitumor activity in vivo following treatment with the microtubule agent ENMD-1198. Mol Cancer Ther 7:1472-1482, 2008
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 1472-1482
-
-
LaVallee, T.M.1
Burke, P.A.2
Swartz, G.M.3
Hamel, E.4
Agoston, G.E.5
Shah, J.6
-
120
-
-
77449141050
-
MET molecular mechanisms and therapies in lung cancer
-
Lawrence RE, Salgia R: MET molecular mechanisms and therapies in lung cancer. Cell Adhes Migr 4:146-152, 2010
-
(2010)
Cell Adhes Migr
, vol.4
, pp. 146-152
-
-
Lawrence, R.E.1
Salgia, R.2
-
121
-
-
76649126249
-
Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression
-
Le A, Cooper CR, Gouw AM, Dinavahi R, Maitra A, Deck LM, et al: Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression. Proc Natl Acad Sci U S A 107:2037-2042, 2010
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 2037-2042
-
-
Le, A.1
Cooper, C.R.2
Gouw, A.M.3
Dinavahi, R.4
Maitra, A.5
Deck, L.M.6
-
122
-
-
82055185047
-
A novel approach to cancer therapy using PX-478 as a HIF-1a inhibitor
-
Lee K, Kim HM: A novel approach to cancer therapy using PX-478 as a HIF-1a inhibitor. Arch Pharm Res 34:1583-1585, 2011
-
(2011)
Arch Pharm Res
, vol.34
, pp. 1583-1585
-
-
Lee, K.1
Kim, H.M.2
-
123
-
-
0028266108
-
Contemporary approaches to the treatment of malignant gliomas with radiation therapy
-
Leibel SA, Scott CB, Loeffler JS: Contemporary approaches to the treatment of malignant gliomas with radiation therapy. Semin Oncol 21:198-219, 1994
-
(1994)
Semin Oncol
, vol.21
, pp. 198-219
-
-
Leibel, S.A.1
Scott, C.B.2
Loeffler, J.S.3
-
124
-
-
84872839243
-
Rapamycin inhibits human glioma cell proliferation through down-regulating mammalian target of rapamycin pathway and up-regulating microRNA-143
-
Li C, Liu Y, Liu J, Chen Y, Li Z, Chen X, et al: Rapamycin inhibits human glioma cell proliferation through down-regulating mammalian target of rapamycin pathway and up-regulating microRNA-143. Head Neck Oncol 4:66, 2012
-
(2012)
Head Neck Oncol
, vol.4
, pp. 66
-
-
Li, C.1
Liu, Y.2
Liu, J.3
Chen, Y.4
Li, Z.5
Chen, X.6
-
125
-
-
84874440951
-
Expression and significance of hypoxia-inducible factor-1a and survivin in laryngeal carcinoma tissue and cells
-
Li DW, Zhou L, Jin B, Xie J, Dong P: Expression and significance of hypoxia-inducible factor-1a and survivin in laryngeal carcinoma tissue and cells. Otolaryngol Head Neck Surg 148:75-81, 2013
-
(2013)
Otolaryngol Head Neck Surg
, vol.148
, pp. 75-81
-
-
Li, D.W.1
Zhou, L.2
Jin, B.3
Xie, J.4
Dong, P.5
-
126
-
-
84863110128
-
Receptor for activated C kinase 1 (RACK1): a regulator for migration and invasion in oral squamous cell carcinoma cells
-
Li J, Guo Y, Feng X, Wang Z, Wang Y, Deng P, et al: Receptor for activated C kinase 1 (RACK1): a regulator for migration and invasion in oral squamous cell carcinoma cells. J Cancer Res Clin Oncol 138:563-571, 2012
-
(2012)
J Cancer Res Clin Oncol
, vol.138
, pp. 563-571
-
-
Li, J.1
Guo, Y.2
Feng, X.3
Wang, Z.4
Wang, Y.5
Deng, P.6
-
127
-
-
0030936323
-
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
-
Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, et al: PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 275:1943-1947, 1997
-
(1997)
Science
, vol.275
, pp. 1943-1947
-
-
Li, J.1
Yen, C.2
Liaw, D.3
Podsypanina, K.4
Bose, S.5
Wang, S.I.6
-
128
-
-
79959971880
-
c-Met signaling induces a reprogramming network and supports the glioblastoma stem-like phenotype
-
Li Y, Li A, Glas M, Lal B, Ying M, Sang Y, et al: c-Met signaling induces a reprogramming network and supports the glioblastoma stem-like phenotype. Proc Natl Acad Sci U S A 108:9951-9956, 2011
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 9951-9956
-
-
Li, Y.1
Li, A.2
Glas, M.3
Lal, B.4
Ying, M.5
Sang, Y.6
-
129
-
-
65749106405
-
Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells
-
Li Z, Bao S, Wu Q, Wang H, Eyler C, Sathornsumetee S, et al: Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells. Cancer Cell 15:501-513, 2009
-
(2009)
Cancer Cell
, vol.15
, pp. 501-513
-
-
Li, Z.1
Bao, S.2
Wu, Q.3
Wang, H.4
Eyler, C.5
Sathornsumetee, S.6
-
130
-
-
77956415557
-
Clotrimazole induces a late G1 cell cycle arrest and sensitizes glioblastoma cells to radiation in vitro
-
Liu H, Li Y, Raisch KP: Clotrimazole induces a late G1 cell cycle arrest and sensitizes glioblastoma cells to radiation in vitro. Anticancer Drugs 21:841-849, 2010
-
(2010)
Anticancer Drugs
, vol.21
, pp. 841-849
-
-
Liu, H.1
Li, Y.2
Raisch, K.P.3
-
131
-
-
33846254999
-
RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha
-
Liu YV, Baek JH, Zhang H, Diez R, Cole RN, Semenza GL: RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha. Mol Cell 25:207-217, 2007
-
(2007)
Mol Cell
, vol.25
, pp. 207-217
-
-
Liu, Y.V.1
Baek, J.H.2
Zhang, H.3
Diez, R.4
Cole, R.N.5
Semenza, G.L.6
-
132
-
-
0037189542
-
Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis
-
Lu H, Forbes RA, Verma A: Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis. J Biol Chem 277:23111-23115, 2002
-
(2002)
J Biol Chem
, vol.277
, pp. 23111-23115
-
-
Lu, H.1
Forbes, R.A.2
Verma, A.3
-
133
-
-
64349100198
-
Grape seed extract inhibits VEGF expression via reducing HIF-1alpha protein expression
-
Lu J, Zhang K, Chen S, Wen W: Grape seed extract inhibits VEGF expression via reducing HIF-1alpha protein expression. Carcinogenesis 30:636-644, 2009
-
(2009)
Carcinogenesis
, vol.30
, pp. 636-644
-
-
Lu, J.1
Zhang, K.2
Chen, S.3
Wen, W.4
-
134
-
-
84896739683
-
Mechanisms of evasive resistance to anti-VEGF therapy in glioblastoma
-
Lu KV, Bergers G: Mechanisms of evasive resistance to anti-VEGF therapy in glioblastoma. CNS Oncol 2:49-65, 2013
-
(2013)
CNS Oncol
, vol.2
, pp. 49-65
-
-
Lu, K.V.1
Bergers, G.2
-
136
-
-
10744231706
-
2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF
-
Mabjeesh NJ, Escuin D, LaVallee TM, Pribluda VS, Swartz GM, Johnson MS, et al: 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF. Cancer Cell 3:363-375, 2003
-
(2003)
Cancer Cell
, vol.3
, pp. 363-375
-
-
Mabjeesh, N.J.1
Escuin, D.2
LaVallee, T.M.3
Pribluda, V.S.4
Swartz, G.M.5
Johnson, M.S.6
-
137
-
-
0036569704
-
Geldanamycin induces degradation of hypoxia-inducible factor 1alpha protein via the proteosome pathway in prostate cancer cells
-
Mabjeesh NJ, Post DE, Willard MT, Kaur B, Van Meir EG, Simons JW, et al: Geldanamycin induces degradation of hypoxia-inducible factor 1alpha protein via the proteosome pathway in prostate cancer cells. Cancer Res 62:2478-2482, 2002
-
(2002)
Cancer Res
, vol.62
, pp. 2478-2482
-
-
Mabjeesh, N.J.1
Post, D.E.2
Willard, M.T.3
Kaur, B.4
Van Meir, E.G.5
Simons, J.W.6
-
138
-
-
0038383678
-
Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth
-
Mack FA, Rathmell WK, Arsham AM, Gnarra J, Keith B, Simon MC: Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth. Cancer Cell 3:75-88, 2003
-
(2003)
Cancer Cell
, vol.3
, pp. 75-88
-
-
Mack, F.A.1
Rathmell, W.K.2
Arsham, A.M.3
Gnarra, J.4
Keith, B.5
Simon, M.C.6
-
139
-
-
84876701208
-
Poly (ethylene)-glycol conjugated solid lipid nanoparticles of noscapine improve biological half-life, brain delivery and efficacy in glioblastoma cells
-
Madan J, Pandey RS, Jain V, Katare OP, Chandra R, Katyal A: Poly (ethylene)-glycol conjugated solid lipid nanoparticles of noscapine improve biological half-life, brain delivery and efficacy in glioblastoma cells. Nanomedicine (Lond Print) 9:492-503, 2013
-
(2013)
Nanomedicine (Lond Print)
, vol.9
, pp. 492-503
-
-
Madan, J.1
Pandey, R.S.2
Jain, V.3
Katare, O.P.4
Chandra, R.5
Katyal, A.6
-
140
-
-
0035887011
-
FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity
-
Mahon PC, Hirota K, Semenza GL: FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev 15:2675-2686, 2001
-
(2001)
Genes Dev
, vol.15
, pp. 2675-2686
-
-
Mahon, P.C.1
Hirota, K.2
Semenza, G.L.3
-
141
-
-
2942724235
-
mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways
-
Majumder PK, Febbo PG, Bikoff R, Berger R, Xue Q, McMahon LM, et al: mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways. Nat Med 10:594-601, 2004
-
(2004)
Nat Med
, vol.10
, pp. 594-601
-
-
Majumder, P.K.1
Febbo, P.G.2
Bikoff, R.3
Berger, R.4
Xue, Q.5
McMahon, L.M.6
-
142
-
-
0031022499
-
Effect of glucose transport inhibitors on vincristine efflux in multidrug-resistant murine erythroleukaemia cells overexpressing the multidrug resistanceassociated protein (MRP) and two glucose transport proteins, GLUT1 and GLUT3
-
Martell RL, Slapak CA, Levy SB: Effect of glucose transport inhibitors on vincristine efflux in multidrug-resistant murine erythroleukaemia cells overexpressing the multidrug resistanceassociated protein (MRP) and two glucose transport proteins, GLUT1 and GLUT3. Br J Cancer 75:161-168, 1997
-
(1997)
Br J Cancer
, vol.75
, pp. 161-168
-
-
Martell, R.L.1
Slapak, C.A.2
Levy, S.B.3
-
143
-
-
33750683969
-
A novel one-armed anti-c-Met antibody inhibits glioblastoma growth in vivo
-
Martens T, Schmidt NO, Eckerich C, Fillbrandt R, Merchant M, Schwall R, et al: A novel one-armed anti-c-Met antibody inhibits glioblastoma growth in vivo. Clin Cancer Res 12:6144-6152, 2006
-
(2006)
Clin Cancer Res
, vol.12
, pp. 6144-6152
-
-
Martens, T.1
Schmidt, N.O.2
Eckerich, C.3
Fillbrandt, R.4
Merchant, M.5
Schwall, R.6
-
144
-
-
84897974538
-
mTORC2 dictates Warburg effect and drug resistance
-
Masui K, Cavenee WK, Mischel PS: mTORC2 dictates Warburg effect and drug resistance. Cell Cycle 13:1053-1054, 2014
-
(2014)
Cell Cycle
, vol.13
, pp. 1053-1054
-
-
Masui, K.1
Cavenee, W.K.2
Mischel, P.S.3
-
145
-
-
84887430714
-
mTOR complex 2 controls glycolytic metabolism in glioblastoma through FoxO acetylation and upregulation of c-Myc
-
Masui K, Tanaka K, Akhavan D, Babic I, Gini B, Matsutani T, et al: mTOR complex 2 controls glycolytic metabolism in glioblastoma through FoxO acetylation and upregulation of c-Myc. Cell Metab 18:726-739, 2013
-
(2013)
Cell Metab
, vol.18
, pp. 726-739
-
-
Masui, K.1
Tanaka, K.2
Akhavan, D.3
Babic, I.4
Gini, B.5
Matsutani, T.6
-
146
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC, Cockman ME, et al: The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399:271-275, 1999
-
(1999)
Nature
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
Wiesener, M.S.2
Chang, G.W.3
Clifford, S.C.4
Vaux, E.C.5
Cockman, M.E.6
-
147
-
-
84877087466
-
Glioblastoma resistance to anti-VEGF therapy: has the challenge been MET?
-
McCarty JH: Glioblastoma resistance to anti-VEGF therapy: has the challenge been MET? Clin Cancer Res 19:1631-1633, 2013
-
(2013)
Clin Cancer Res
, vol.19
, pp. 1631-1633
-
-
McCarty, J.H.1
-
148
-
-
84861762712
-
Carbonic anhydrase IX promotes tumor growth and necrosis in vivo and inhibition enhances anti-VEGF therapy
-
McIntyre A, Patiar S, Wigfield S, Li JL, Ledaki I, Turley H, et al: Carbonic anhydrase IX promotes tumor growth and necrosis in vivo and inhibition enhances anti-VEGF therapy. Clin Cancer Res 18:3100-3111, 2012
-
(2012)
Clin Cancer Res
, vol.18
, pp. 3100-3111
-
-
McIntyre, A.1
Patiar, S.2
Wigfield, S.3
Li, J.L.4
Ledaki, I.5
Turley, H.6
-
149
-
-
84867514301
-
Targeting hypoxia, HIF-1, and tumor glucose metabolism to improve radiotherapy efficacy
-
Meijer TW, Kaanders JH, Span PN, Bussink J: Targeting hypoxia, HIF-1, and tumor glucose metabolism to improve radiotherapy efficacy. Clin Cancer Res 18:5585-5594, 2012
-
(2012)
Clin Cancer Res
, vol.18
, pp. 5585-5594
-
-
Meijer, T.W.1
Kaanders, J.H.2
Span, P.N.3
Bussink, J.4
-
150
-
-
34347206794
-
Hypoxia inhibits paclitaxel-induced apoptosis through adenosine-mediated phosphorylation of bad in glioblastoma cells
-
Merighi S, Benini A, Mirandola P, Gessi S, Varani K, Leung E, et al: Hypoxia inhibits paclitaxel-induced apoptosis through adenosine-mediated phosphorylation of bad in glioblastoma cells. Mol Pharmacol 72:162-172, 2007
-
(2007)
Mol Pharmacol
, vol.72
, pp. 162-172
-
-
Merighi, S.1
Benini, A.2
Mirandola, P.3
Gessi, S.4
Varani, K.5
Leung, E.6
-
151
-
-
84869748840
-
Biochemical and pharmacological characterization of human c-Met neutralizing monoclonal antibody CE-355621
-
Michaud NR, Jani JP, Hillerman S, Tsaparikos KE, Barbacci-Tobin EG, Knauth E, et al: Biochemical and pharmacological characterization of human c-Met neutralizing monoclonal antibody CE-355621. MAbs 4:710-723, 2012
-
(2012)
MAbs
, vol.4
, pp. 710-723
-
-
Michaud, N.R.1
Jani, J.P.2
Hillerman, S.3
Tsaparikos, K.E.4
Barbacci-Tobin, E.G.5
Knauth, E.6
-
152
-
-
77952995998
-
Metabolic modulation of glioblastoma with dichloroacetate
-
Michelakis ED, Sutendra G, Dromparis P, Webster L, Haromy A, Niven E, et al: Metabolic modulation of glioblastoma with dichloroacetate. Sci Transl Med 2:31ra34, 2010
-
(2010)
Sci Transl Med
, vol.2
, pp. 31ra34
-
-
Michelakis, E.D.1
Sutendra, G.2
Dromparis, P.3
Webster, L.4
Haromy, A.5
Niven, E.6
-
153
-
-
0037225763
-
Inhibition of hypoxia-induced angiogenesis by FK228, a specific histone deacetylase inhibitor, via suppression of HIF-1alpha activity
-
Mie Lee Y, Kim SH, Kim HS, Jin Son M, Nakajima H, Jeong Kwon H, et al: Inhibition of hypoxia-induced angiogenesis by FK228, a specific histone deacetylase inhibitor, via suppression of HIF-1alpha activity. Biochem Biophys Res Commun 300:241-246, 2003
-
(2003)
Biochem Biophys Res Commun
, vol.300
, pp. 241-246
-
-
Mie Lee, Y.1
Kim, S.H.2
Kim, H.S.3
Jin Son, M.4
Nakajima, H.5
Jeong Kwon, H.6
-
154
-
-
84866437189
-
17AEP-GA, an HSP90 antagonist, is a potent inhibitor of glioblastoma cell proliferation, survival, migration and invasion
-
Miekus K, Kijowski J, Sekula M, Majka M: 17AEP-GA, an HSP90 antagonist, is a potent inhibitor of glioblastoma cell proliferation, survival, migration and invasion. Oncol Rep 28:1903-1909, 2012
-
(2012)
Oncol Rep
, vol.28
, pp. 1903-1909
-
-
Miekus, K.1
Kijowski, J.2
Sekula, M.3
Majka, M.4
-
155
-
-
84874377917
-
Increased radiosensitivity and radiothermosensitivity of human pancreatic MIA PaCa-2 and U251 glioblastoma cell lines treated with the novel Hsp90 inhibitor NVP-HSP990
-
Milanovic D, Firat E, Grosu AL, Niedermann G: Increased radiosensitivity and radiothermosensitivity of human pancreatic MIA PaCa-2 and U251 glioblastoma cell lines treated with the novel Hsp90 inhibitor NVP-HSP990. Radiat Oncol 8:42, 2013
-
(2013)
Radiat Oncol
, vol.8
, pp. 42
-
-
Milanovic, D.1
Firat, E.2
Grosu, A.L.3
Niedermann, G.4
-
156
-
-
31544443522
-
The evolution of chemoradiation for glioblastoma: a modern success story
-
Mirimanoff RO: The evolution of chemoradiation for glioblastoma: a modern success story. Curr Oncol Rep 8:50-53, 2006
-
(2006)
Curr Oncol Rep
, vol.8
, pp. 50-53
-
-
Mirimanoff, R.O.1
-
157
-
-
84866950193
-
Comparison of spheroids formed by rat glioma stem cells and neural stem cells reveals differences in glucose metabolism and promising therapeutic applications
-
Morfouace M, Lalier L, Bahut M, Bonnamain V, Naveilhan P, Guette C, et al: Comparison of spheroids formed by rat glioma stem cells and neural stem cells reveals differences in glucose metabolism and promising therapeutic applications. J Biol Chem 287:33664-33674, 2012
-
(2012)
J Biol Chem
, vol.287
, pp. 33664-33674
-
-
Morfouace, M.1
Lalier, L.2
Bahut, M.3
Bonnamain, V.4
Naveilhan, P.5
Guette, C.6
-
158
-
-
84878211420
-
Menadione and ethacrynic acid inhibit the hypoxia-inducible factor (HIF) pathway by disrupting HIF-1a interaction with p300
-
Na YR, Han KC, Park H, Yang EG: Menadione and ethacrynic acid inhibit the hypoxia-inducible factor (HIF) pathway by disrupting HIF-1a interaction with p300. Biochem Biophys Res Commun 434:879-884, 2013
-
(2013)
Biochem Biophys Res Commun
, vol.434
, pp. 879-884
-
-
Na, Y.R.1
Han, K.C.2
Park, H.3
Yang, E.G.4
-
159
-
-
20244374417
-
Human bone marrow-derived mesenchymal stem cells in the treatment of gliomas
-
Nakamizo A, Marini F, Amano T, Khan A, Studeny M, Gumin J, et al: Human bone marrow-derived mesenchymal stem cells in the treatment of gliomas. Cancer Res 65:3307-3318, 2005
-
(2005)
Cancer Res
, vol.65
, pp. 3307-3318
-
-
Nakamizo, A.1
Marini, F.2
Amano, T.3
Khan, A.4
Studeny, M.5
Gumin, J.6
-
160
-
-
78650797956
-
Zinc downregulates HIF-1a and inhibits its activity in tumor cells in vitro and in vivo
-
Nardinocchi L, Pantisano V, Puca R, Porru M, Aiello A, Grasselli A, et al: Zinc downregulates HIF-1a and inhibits its activity in tumor cells in vitro and in vivo. PLoS ONE 5:e15048, 2010
-
(2010)
PLoS ONE
, vol.5
-
-
Nardinocchi, L.1
Pantisano, V.2
Puca, R.3
Porru, M.4
Aiello, A.5
Grasselli, A.6
-
161
-
-
70349696534
-
Identification of a novel small molecule HIF-1alpha translation inhibitor
-
Narita T, Yin S, Gelin CF, Moreno CS, Yepes M, Nicolaou KC, et al: Identification of a novel small molecule HIF-1alpha translation inhibitor. Clin Cancer Res 15:6128-6136, 2009
-
(2009)
Clin Cancer Res
, vol.15
, pp. 6128-6136
-
-
Narita, T.1
Yin, S.2
Gelin, C.F.3
Moreno, C.S.4
Yepes, M.5
Nicolaou, K.C.6
-
162
-
-
84874593624
-
Effects of dual targeting of tumor cells and stroma in human glioblastoma xenografts with a tyrosine kinase inhibitor against c-MET and VEGFR2
-
Navis AC, Bourgonje A, Wesseling P, Wright A, Hendriks W, Verrijp K, et al: Effects of dual targeting of tumor cells and stroma in human glioblastoma xenografts with a tyrosine kinase inhibitor against c-MET and VEGFR2. PLoS ONE 8:e58262, 2013
-
(2013)
PLoS ONE
, vol.8
-
-
Navis, A.C.1
Bourgonje, A.2
Wesseling, P.3
Wright, A.4
Hendriks, W.5
Verrijp, K.6
-
163
-
-
53749106421
-
Noscapine induces apoptosis in human glioma cells by an apoptosis-inducing factor-dependent pathway
-
Newcomb EW, Lukyanov Y, Smirnova I, Schnee T, Zagzag D: Noscapine induces apoptosis in human glioma cells by an apoptosis-inducing factor-dependent pathway. Anticancer Drugs 19:553-563, 2008
-
(2008)
Anticancer Drugs
, vol.19
, pp. 553-563
-
-
Newcomb, E.W.1
Lukyanov, Y.2
Smirnova, I.3
Schnee, T.4
Zagzag, D.5
-
164
-
-
0026647928
-
Distribution of the glucose transporters in human brain tumors
-
Nishioka T, Oda Y, Seino Y, Yamamoto T, Inagaki N, Yano H, et al: Distribution of the glucose transporters in human brain tumors. Cancer Res 52:3972-3979, 1992
-
(1992)
Cancer Res
, vol.52
, pp. 3972-3979
-
-
Nishioka, T.1
Oda, Y.2
Seino, Y.3
Yamamoto, T.4
Inagaki, N.5
Yano, H.6
-
165
-
-
70349653793
-
IDH1 mutations as molecular signature and predictive factor of secondary glioblastomas
-
Nobusawa S, Watanabe T, Kleihues P, Ohgaki H: IDH1 mutations as molecular signature and predictive factor of secondary glioblastomas. Clin Cancer Res 15:6002-6007, 2009
-
(2009)
Clin Cancer Res
, vol.15
, pp. 6002-6007
-
-
Nobusawa, S.1
Watanabe, T.2
Kleihues, P.3
Ohgaki, H.4
-
166
-
-
84874091180
-
The definition of primary and secondary glioblastoma
-
Ohgaki H, Kleihues P: The definition of primary and secondary glioblastoma. Clin Cancer Res 19:764-772, 2013
-
(2013)
Clin Cancer Res
, vol.19
, pp. 764-772
-
-
Ohgaki, H.1
Kleihues, P.2
-
167
-
-
0033776536
-
Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein
-
Ohh M, Park CW, Ivan M, Hoffman MA, Kim TY, Huang LE, et al: Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein. Nat Cell Biol 2:423-427, 2000
-
(2000)
Nat Cell Biol
, vol.2
, pp. 423-427
-
-
Ohh, M.1
Park, C.W.2
Ivan, M.3
Hoffman, M.A.4
Kim, T.Y.5
Huang, L.E.6
-
168
-
-
84893719338
-
The immunohistochemical expression of c-Met is an independent predictor of survival in patients with glioblastoma multiforme
-
Olmez OF, Cubukcu E, Evrensel T, Kurt M, Avci N, Tolunay S, et al: The immunohistochemical expression of c-Met is an independent predictor of survival in patients with glioblastoma multiforme. Clin Transl Oncol 16:173-177, 2014
-
(2014)
Clin Transl Oncol
, vol.16
, pp. 173-177
-
-
Olmez, O.F.1
Cubukcu, E.2
Evrensel, T.3
Kurt, M.4
Avci, N.5
Tolunay, S.6
-
169
-
-
72849115544
-
Development of HIF-1 inhibitors for cancer therapy
-
Onnis B, Rapisarda A, Melillo G: Development of HIF-1 inhibitors for cancer therapy. J Cell Mol Med 13 (9A):2780-2786, 2009
-
(2009)
J Cell Mol Med
, vol.13
, Issue.9 A
, pp. 2780-2786
-
-
Onnis, B.1
Rapisarda, A.2
Melillo, G.3
-
170
-
-
4544325479
-
Apigenin suppresses the expression of VEGF, an important factor for angiogenesis, in endothelial cells via degradation of HIF-1alpha protein
-
Osada M, Imaoka S, Funae Y: Apigenin suppresses the expression of VEGF, an important factor for angiogenesis, in endothelial cells via degradation of HIF-1alpha protein. FEBS Lett 575:59-63, 2004
-
(2004)
FEBS Lett
, vol.575
, pp. 59-63
-
-
Osada, M.1
Imaoka, S.2
Funae, Y.3
-
171
-
-
84885051395
-
Forced downregulation of RACK1 inhibits glioma development by suppressing Src/Akt signaling activity
-
Peng R, Jiang B, Ma J, Ma Z, Wan X, Liu H, et al: Forced downregulation of RACK1 inhibits glioma development by suppressing Src/Akt signaling activity. Oncol Rep 30:2195-2202, 2013
-
(2013)
Oncol Rep
, vol.30
, pp. 2195-2202
-
-
Peng, R.1
Jiang, B.2
Ma, J.3
Ma, Z.4
Wan, X.5
Liu, H.6
-
172
-
-
34250724520
-
The SDF-1-CXCR4 signaling pathway: a molecular hub modulating neo-angiogenesis
-
Petit I, Jin D, Rafii S: The SDF-1-CXCR4 signaling pathway: a molecular hub modulating neo-angiogenesis. Trends Immunol 28:299-307, 2007
-
(2007)
Trends Immunol
, vol.28
, pp. 299-307
-
-
Petit, I.1
Jin, D.2
Rafii, S.3
-
173
-
-
84883009929
-
Acquired resistance to anti-VEGF therapy in glioblastoma is associated with a mesenchymal transition
-
Piao Y, Liang J, Holmes L, Henry V, Sulman E, de Groot JF: Acquired resistance to anti-VEGF therapy in glioblastoma is associated with a mesenchymal transition. Clin Cancer Res 19:4392-4403, 2013
-
(2013)
Clin Cancer Res
, vol.19
, pp. 4392-4403
-
-
Piao, Y.1
Liang, J.2
Holmes, L.3
Henry, V.4
Sulman, E.5
de Groot, J.F.6
-
174
-
-
84893342957
-
Isocitrate dehydrogenase-1 mutations as prognostic biomarker in glioblastoma multiforme patients in West Bohemia
-
Polivka J, Polivka J Jr, Rohan V, Pesta M, Repik T, Pitule P, et al: Isocitrate dehydrogenase-1 mutations as prognostic biomarker in glioblastoma multiforme patients in West Bohemia. Biomed Res Int 2014:735659, 2014
-
(2014)
Biomed Res Int
, vol.2014
, pp. 735659
-
-
Polivka, J.1
Polivka Jr, J.2
Rohan, V.3
Pesta, M.4
Repik, T.5
Pitule, P.6
-
175
-
-
26444570010
-
Accumulation of Krebs cycle intermediates and overexpression of HIF1alpha in tumours which result from germline FH and SDH mutations
-
Pollard PJ, Brière JJ, Alam NA, Barwell J, Barclay E, Wortham NC, et al: Accumulation of Krebs cycle intermediates and overexpression of HIF1alpha in tumours which result from germline FH and SDH mutations. Hum Mol Genet 14:2231-2239, 2005
-
(2005)
Hum Mol Genet
, vol.14
, pp. 2231-2239
-
-
Pollard, P.J.1
Brière, J.J.2
Alam, N.A.3
Barwell, J.4
Barclay, E.5
Wortham, N.C.6
-
176
-
-
33750728003
-
HIV protease inhibitors decrease VEGF/HIF-1alpha expression and angiogenesis in glioblastoma cells
-
Pore N, Gupta AK, Cerniglia GJ, Maity A: HIV protease inhibitors decrease VEGF/HIF-1alpha expression and angiogenesis in glioblastoma cells. Neoplasia 8:889-895, 2006
-
(2006)
Neoplasia
, vol.8
, pp. 889-895
-
-
Pore, N.1
Gupta, A.K.2
Cerniglia, G.J.3
Maity, A.4
-
177
-
-
74249111545
-
Ansamycin inhibitors of Hsp90: nature's prototype for anti-chaperone therapy
-
Porter JR, Ge J, Lee J, Normant E, West K: Ansamycin inhibitors of Hsp90: nature's prototype for anti-chaperone therapy. Curr Top Med Chem 9:1386-1418, 2009
-
(2009)
Curr Top Med Chem
, vol.9
, pp. 1386-1418
-
-
Porter, J.R.1
Ge, J.2
Lee, J.3
Normant, E.4
West, K.5
-
178
-
-
84876004187
-
Reversing the Warburg effect as a treatment for glioblastoma
-
Poteet E, Choudhury GR, Winters A, Li W, Ryou MG, Liu R, et al: Reversing the Warburg effect as a treatment for glioblastoma. J Biol Chem 288:9153-9164, 2013
-
(2013)
J Biol Chem
, vol.288
, pp. 9153-9164
-
-
Poteet, E.1
Choudhury, G.R.2
Winters, A.3
Li, W.4
Ryou, M.G.5
Liu, R.6
-
179
-
-
0042847064
-
Diagnostic, prognostic and therapeutic implications of carbonic anhydrases in cancer
-
Potter CP, Harris AL: Diagnostic, prognostic and therapeutic implications of carbonic anhydrases in cancer. Br J Cancer 89:2-7, 2003
-
(2003)
Br J Cancer
, vol.89
, pp. 2-7
-
-
Potter, C.P.1
Harris, A.L.2
-
180
-
-
84868011381
-
Function of carbonic anhydrase IX in glioblastoma multiforme
-
Proescholdt MA, Merrill MJ, Stoerr EM, Lohmeier A, Pohl F, Brawanski A: Function of carbonic anhydrase IX in glioblastoma multiforme. Neuro Oncol 14:1357-1366, 2012
-
(2012)
Neuro Oncol
, vol.14
, pp. 1357-1366
-
-
Proescholdt, M.A.1
Merrill, M.J.2
Stoerr, E.M.3
Lohmeier, A.4
Pohl, F.5
Brawanski, A.6
-
181
-
-
84881441534
-
Synergistic suppression of noscapine and conventional chemotherapeutics on human glioblastoma cell growth
-
Qi Q, Liu X, Li S, Joshi HC, Ye K: Synergistic suppression of noscapine and conventional chemotherapeutics on human glioblastoma cell growth. Acta Pharmacol Sin 34:930-938, 2013
-
(2013)
Acta Pharmacol Sin
, vol.34
, pp. 930-938
-
-
Qi, Q.1
Liu, X.2
Li, S.3
Joshi, H.C.4
Ye, K.5
-
182
-
-
1242271198
-
Topoisomerase I-mediated inhibition of hypoxiainducible factor 1: mechanism and therapeutic implications
-
Rapisarda A, Uranchimeg B, Sordet O, Pommier Y, Shoemaker RH, Melillo G: Topoisomerase I-mediated inhibition of hypoxiainducible factor 1: mechanism and therapeutic implications. Cancer Res 64:1475-1482, 2004
-
(2004)
Cancer Res
, vol.64
, pp. 1475-1482
-
-
Rapisarda, A.1
Uranchimeg, B.2
Sordet, O.3
Pommier, Y.4
Shoemaker, R.H.5
Melillo, G.6
-
183
-
-
4944229705
-
Schedule-dependent inhibition of hypoxia-inducible factor-1alpha protein accumulation, angiogenesis, and tumor growth by topotecan in U251-HRE glioblastoma xenografts
-
Rapisarda A, Zalek J, Hollingshead M, Braunschweig T, Uranchimeg B, Bonomi CA, et al: Schedule-dependent inhibition of hypoxia-inducible factor-1alpha protein accumulation, angiogenesis, and tumor growth by topotecan in U251-HRE glioblastoma xenografts. Cancer Res 64:6845-6848, 2004
-
(2004)
Cancer Res
, vol.64
, pp. 6845-6848
-
-
Rapisarda, A.1
Zalek, J.2
Hollingshead, M.3
Braunschweig, T.4
Uranchimeg, B.5
Bonomi, C.A.6
-
184
-
-
35148870732
-
Glut-1 antibodies induce growth arrest and apoptosis in human cancer cell lines
-
Rastogi S, Banerjee S, Chellappan S, Simon GR: Glut-1 antibodies induce growth arrest and apoptosis in human cancer cell lines. Cancer Lett 257:244-251, 2007
-
(2007)
Cancer Lett
, vol.257
, pp. 244-251
-
-
Rastogi, S.1
Banerjee, S.2
Chellappan, S.3
Simon, G.R.4
-
185
-
-
84875800035
-
In vivo c-Met pathway inhibition depletes human glioma xenografts of tumorpropagating stem-like cells
-
Rath P, Lal B, Ajala O, Li Y, Xia S, Kim J, et al: In vivo c-Met pathway inhibition depletes human glioma xenografts of tumorpropagating stem-like cells. Transl Oncol 6:104-111, 2013
-
(2013)
Transl Oncol
, vol.6
, pp. 104-111
-
-
Rath, P.1
Lal, B.2
Ajala, O.3
Li, Y.4
Xia, S.5
Kim, J.6
-
186
-
-
1642453727
-
Identification of necrosis-associated genes in glioblastoma by cDNA microarray analysis
-
Raza SM, Fuller GN, Rhee CH, Huang S, Hess K, Zhang W, et al: Identification of necrosis-associated genes in glioblastoma by cDNA microarray analysis. Clin Cancer Res 10:212-221, 2004
-
(2004)
Clin Cancer Res
, vol.10
, pp. 212-221
-
-
Raza, S.M.1
Fuller, G.N.2
Rhee, C.H.3
Huang, S.4
Hess, K.5
Zhang, W.6
-
187
-
-
84900029890
-
Epidithiodiketopiperazines (ETPs) exhibit in vitro antiangiogenic and in vivo antitumor activity by disrupting the HIF-1a/p300 complex in a preclinical model of prostate cancer
-
Reece KM, Richardson ED, Cook KM, Campbell TJ, Pisle ST, Holly AJ, et al: Epidithiodiketopiperazines (ETPs) exhibit in vitro antiangiogenic and in vivo antitumor activity by disrupting the HIF-1a/p300 complex in a preclinical model of prostate cancer. Mol Cancer 13:91, 2014
-
(2014)
Mol Cancer
, vol.13
, pp. 91
-
-
Reece, K.M.1
Richardson, E.D.2
Cook, K.M.3
Campbell, T.J.4
Pisle, S.T.5
Holly, A.J.6
-
188
-
-
1642377561
-
ONCOMINE: a cancer microarray database and integrated data-mining platform
-
Rhodes DR, Yu J, Shanker K, Deshpande N, Varambally R, Ghosh D, et al: ONCOMINE: a cancer microarray database and integrated data-mining platform. Neoplasia 6:1-6, 2004
-
(2004)
Neoplasia
, vol.6
, pp. 1-6
-
-
Rhodes, D.R.1
Yu, J.2
Shanker, K.3
Deshpande, N.4
Varambally, R.5
Ghosh, D.6
-
189
-
-
0004580887
-
Transient hypoxia enhances the frequency of dihydrofolate reductase gene amplification in Chinese hamster ovary cells
-
Rice GC, Hoy C, Schimke RT: Transient hypoxia enhances the frequency of dihydrofolate reductase gene amplification in Chinese hamster ovary cells. Proc Natl Acad Sci U S A 83:5978-5982, 1986
-
(1986)
Proc Natl Acad Sci U S A
, vol.83
, pp. 5978-5982
-
-
Rice, G.C.1
Hoy, C.2
Schimke, R.T.3
-
191
-
-
18644366801
-
Hypoxiainducible factor-1alpha and the glycolytic phenotype in tumors
-
Robey IF, Lien AD, Welsh SJ, Baggett BK, Gillies RJ: Hypoxiainducible factor-1alpha and the glycolytic phenotype in tumors. Neoplasia 7:324-330, 2005
-
(2005)
Neoplasia
, vol.7
, pp. 324-330
-
-
Robey, I.F.1
Lien, A.D.2
Welsh, S.J.3
Baggett, B.K.4
Gillies, R.J.5
-
192
-
-
33746696738
-
'Pseudopalisading' necrosis in glioblastoma: a familiar morphologic feature that links vascular pathology, hypoxia, and angiogenesis
-
Rong Y, Durden DL, Van Meir EG, Brat DJ: 'Pseudopalisading' necrosis in glioblastoma: a familiar morphologic feature that links vascular pathology, hypoxia, and angiogenesis. J Neuropathol Exp Neurol 65:529-539, 2006
-
(2006)
JNeuropathol Exp Neurol
, vol.65
, pp. 529-539
-
-
Rong, Y.1
Durden, D.L.2
Van Meir, E.G.3
Brat, D.J.4
-
193
-
-
81955160750
-
Metabolism of glioma and IDH1/IDH2 mutations
-
Rossetto M, Ciccarino P, Boisselier B, Labussiere M, Sanson M: Metabolism of glioma and IDH1/IDH2 mutations. Rev Neurol (Paris) 167:699-703, 2011
-
(2011)
Rev Neurol (Paris)
, vol.167
, pp. 699-703
-
-
Rossetto, M.1
Ciccarino, P.2
Boisselier, B.3
Labussiere, M.4
Sanson, M.5
-
194
-
-
84878569070
-
Hypoxia induced CA9 inhibitory targeting by two different sulfonamide derivatives including acetazolamide in human glioblastoma
-
Said HM, Hagemann C, Carta F, Katzer A, Polat B, Staab A, et al: Hypoxia induced CA9 inhibitory targeting by two different sulfonamide derivatives including acetazolamide in human glioblastoma. Bioorg Med Chem 21:3949-3957, 2013
-
(2013)
Bioorg Med Chem
, vol.21
, pp. 3949-3957
-
-
Said, H.M.1
Hagemann, C.2
Carta, F.3
Katzer, A.4
Polat, B.5
Staab, A.6
-
195
-
-
84881479778
-
Targeting the PI3K/AKT/mTOR signaling pathway in glioblastoma: novel therapeutic agents and advances in understanding
-
Sami A, Karsy M: Targeting the PI3K/AKT/mTOR signaling pathway in glioblastoma: novel therapeutic agents and advances in understanding. Tumour Biol 34:1991-2002, 2013
-
(2013)
Tumour Biol
, vol.34
, pp. 1991-2002
-
-
Sami, A.1
Karsy, M.2
-
196
-
-
0028061116
-
Hypoxia-induced resistance to doxorubicin and methotrexate in human melanoma cell lines in vitro
-
Sanna K, Rofstad EK: Hypoxia-induced resistance to doxorubicin and methotrexate in human melanoma cell lines in vitro. Int J Cancer 58:258-262, 1994
-
(1994)
Int J Cancer
, vol.58
, pp. 258-262
-
-
Sanna, K.1
Rofstad, E.K.2
-
197
-
-
49649104978
-
Mechanisms of chemoresistance to alkylating agents in malignant glioma
-
Sarkaria JN, Kitange GJ, James CD, Plummer R, Calvert H, Weller M, et al: Mechanisms of chemoresistance to alkylating agents in malignant glioma. Clin Cancer Res 14:2900-2908, 2008
-
(2008)
Clin Cancer Res
, vol.14
, pp. 2900-2908
-
-
Sarkaria, J.N.1
Kitange, G.J.2
James, C.D.3
Plummer, R.4
Calvert, H.5
Weller, M.6
-
198
-
-
38349155463
-
Tumor angiogenic and hypoxic profiles predict radiographic response and survival in malignant astrocytoma patients treated with bevacizumab and irinotecan
-
Sathornsumetee S, Cao Y, Marcello JE, Herndon JE II, McLendon RE, Desjardins A, et al: Tumor angiogenic and hypoxic profiles predict radiographic response and survival in malignant astrocytoma patients treated with bevacizumab and irinotecan. J Clin Oncol 26:271-278, 2008
-
(2008)
J Clin Oncol
, vol.26
, pp. 271-278
-
-
Sathornsumetee, S.1
Cao, Y.2
Marcello, J.E.3
Herndon II, J.E.4
McLendon, R.E.5
Desjardins, A.6
-
199
-
-
19944433653
-
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase
-
Selak MA, Armour SM, MacKenzie ED, Boulahbel H, Watson DG, Mansfield KD, et al: Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase. Cancer Cell 7:77-85, 2005
-
(2005)
Cancer Cell
, vol.7
, pp. 77-85
-
-
Selak, M.A.1
Armour, S.M.2
MacKenzie, E.D.3
Boulahbel, H.4
Watson, D.G.5
Mansfield, K.D.6
-
200
-
-
84891434767
-
Lactate-modulated induction of THBS-1 activates transforming growth factor (TGF)-beta2 and migration of glioma cells in vitro
-
Seliger C, Leukel P, Moeckel S, Jachnik B, Lottaz C, Kreutz M, et al: Lactate-modulated induction of THBS-1 activates transforming growth factor (TGF)-beta2 and migration of glioma cells in vitro. PLoS ONE 8:e78935, 2013
-
(2013)
PLoS ONE
, vol.8
-
-
Seliger, C.1
Leukel, P.2
Moeckel, S.3
Jachnik, B.4
Lottaz, C.5
Kreutz, M.6
-
201
-
-
78549283855
-
Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1
-
Seltzer MJ, Bennett BD, Joshi AD, Gao P, Thomas AG, Ferraris DV, et al: Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1. Cancer Res 70:8981-8987, 2010
-
(2010)
Cancer Res
, vol.70
, pp. 8981-8987
-
-
Seltzer, M.J.1
Bennett, B.D.2
Joshi, A.D.3
Gao, P.4
Thomas, A.G.5
Ferraris, D.V.6
-
202
-
-
84883501150
-
HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
-
Semenza GL: HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations. J Clin Invest 123:3664-3671, 2013
-
(2013)
J Clin Invest
, vol.123
, pp. 3664-3671
-
-
Semenza, G.L.1
-
203
-
-
76049100577
-
HIF-1: upstream and downstream of cancer metabolism
-
Semenza GL: HIF-1: upstream and downstream of cancer metabolism. Curr Opin Genet Dev 20:51-56, 2010
-
(2010)
Curr Opin Genet Dev
, vol.20
, pp. 51-56
-
-
Semenza, G.L.1
-
204
-
-
35148828429
-
Hypoxia-inducible factor 1 (HIF-1) pathway
-
Semenza GL: Hypoxia-inducible factor 1 (HIF-1) pathway. Sci STKE 2007:cm8, 2007
-
(2007)
Sci STKE
, vol.2007
-
-
Semenza, G.L.1
-
205
-
-
3042693287
-
Increase of SUMO-1 expression in response to hypoxia: direct interaction with HIF-1alpha in adult mouse brain and heart in vivo
-
Shao R, Zhang FP, Tian F, Anders Friberg P, Wang X, Sjöland H, et al: Increase of SUMO-1 expression in response to hypoxia: direct interaction with HIF-1alpha in adult mouse brain and heart in vivo. FEBS Lett 569:293-300, 2004
-
(2004)
FEBS Lett
, vol.569
, pp. 293-300
-
-
Shao, R.1
Zhang, F.P.2
Tian, F.3
Anders Friberg, P.4
Wang, X.5
Sjöland, H.6
-
206
-
-
79951676430
-
Ras regulates interleukin-1b-induced HIF-1a transcriptional activity in glioblastoma
-
Sharma V, Dixit D, Koul N, Mehta VS, Sen E: Ras regulates interleukin-1b-induced HIF-1a transcriptional activity in glioblastoma. J Mol Med (Berl) 89:123-136, 2011
-
(2011)
J Mol Med (Berl)
, vol.89
, pp. 123-136
-
-
Sharma, V.1
Dixit, D.2
Koul, N.3
Mehta, V.S.4
Sen, E.5
-
207
-
-
42449130564
-
Bortezomib inhibits tumor adaptation to hypoxia by stimulating the FIHmediated repression of hypoxia-inducible factor-1
-
Shin DH, Chun YS, Lee DS, Huang LE, Park JW: Bortezomib inhibits tumor adaptation to hypoxia by stimulating the FIHmediated repression of hypoxia-inducible factor-1. Blood 111:3131-3136, 2008
-
(2008)
Blood
, vol.111
, pp. 3131-3136
-
-
Shin, D.H.1
Chun, Y.S.2
Lee, D.S.3
Huang, L.E.4
Park, J.W.5
-
209
-
-
0036284020
-
Expression of hypoxia-inducible factor 1alpha in tumours of patients with glioblastoma
-
Søndergaard KL, Hilton DA, Penney M, Ollerenshaw M, Demaine AG: Expression of hypoxia-inducible factor 1alpha in tumours of patients with glioblastoma. Neuropathol Appl Neurobiol 28:210-217, 2002
-
(2002)
Neuropathol Appl Neurobiol
, vol.28
, pp. 210-217
-
-
Søndergaard, K.L.1
Hilton, D.A.2
Penney, M.3
Ollerenshaw, M.4
Demaine, A.G.5
-
210
-
-
38349000624
-
Hypoxia-inducible factor-1alpha-induced differentiation of myeloid leukemic cells is its transcriptional activity independent
-
Song LP, Zhang J, Wu SF, Huang Y, Zhao Q, Cao JP, et al: Hypoxia-inducible factor-1alpha-induced differentiation of myeloid leukemic cells is its transcriptional activity independent. Oncogene 27:519-527, 2008
-
(2008)
Oncogene
, vol.27
, pp. 519-527
-
-
Song, L.P.1
Zhang, J.2
Wu, S.F.3
Huang, Y.4
Zhao, Q.5
Cao, J.P.6
-
211
-
-
0030009382
-
Deletion mapping of chromosome 10 in human glioma
-
Sonoda Y, Murakami Y, Tominaga T, Kayama T, Yoshimoto T, Sekiya T: Deletion mapping of chromosome 10 in human glioma. Jpn J Cancer Res 87:363-367, 1996
-
(1996)
Jpn J Cancer Res
, vol.87
, pp. 363-367
-
-
Sonoda, Y.1
Murakami, Y.2
Tominaga, T.3
Kayama, T.4
Yoshimoto, T.5
Sekiya, T.6
-
212
-
-
0043123069
-
Carbonic anhydrase-9 expression levels and prognosis in human breast cancer: association with treatment outcome
-
Span PN, Bussink J, Manders P, Beex LV, Sweep CG: Carbonic anhydrase-9 expression levels and prognosis in human breast cancer: association with treatment outcome. Br J Cancer 89:271-276, 2003
-
(2003)
Br J Cancer
, vol.89
, pp. 271-276
-
-
Span, P.N.1
Bussink, J.2
Manders, P.3
Beex, L.V.4
Sweep, C.G.5
-
213
-
-
84901272598
-
IDH1/IDH2 but not TP53 mutations predict prognosis in Bulgarian glioblastoma patients
-
Stancheva G, Goranova T, Laleva M, Kamenova M, Mitkova A, Velinov N, et al: IDH1/IDH2 but not TP53 mutations predict prognosis in Bulgarian glioblastoma patients. Biomed Res Int 2014:654727, 2014
-
(2014)
Biomed Res Int
, vol.2014
, pp. 654727
-
-
Stancheva, G.1
Goranova, T.2
Laleva, M.3
Kamenova, M.4
Mitkova, A.5
Velinov, N.6
-
214
-
-
35348964557
-
Advances in radiation therapy for brain tumors
-
Stieber VW, Mehta MP: Advances in radiation therapy for brain tumors. Neurol Clin 25:1005-1033, ix, 2007
-
(2007)
Neurol Clin
, vol.25
, pp. 1005-1033+9
-
-
Stieber, V.W.1
Mehta, M.P.2
-
216
-
-
20444456659
-
The role of radio- and chemotherapy in glioblastoma
-
Stupp R, Weber DC: The role of radio- and chemotherapy in glioblastoma. Onkologie 28:315-317, 2005
-
(2005)
Onkologie
, vol.28
, pp. 315-317
-
-
Stupp, R.1
Weber, D.C.2
-
217
-
-
41149149805
-
Differential expression of Glut 1 mRNA and protein levels correlates with increased sensitivity to the glycoconjugated nitric oxide donor (2-glu-SNAP) in different tumor cell types
-
Subbarayan PR, Wang PG, Lampidis TJ, Ardalan B, Braunschweiger P: Differential expression of Glut 1 mRNA and protein levels correlates with increased sensitivity to the glycoconjugated nitric oxide donor (2-glu-SNAP) in different tumor cell types. J Chemother 20:106-111, 2008
-
(2008)
J Chemother
, vol.20
, pp. 106-111
-
-
Subbarayan, P.R.1
Wang, P.G.2
Lampidis, T.J.3
Ardalan, B.4
Braunschweiger, P.5
-
218
-
-
84880439188
-
The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling
-
Sullivan LB, Martinez-Garcia E, Nguyen H, Mullen AR, Dufour E, Sudarshan S, et al: The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling. Mol Cell 51:236-248, 2013
-
(2013)
Mol Cell
, vol.51
, pp. 236-248
-
-
Sullivan, L.B.1
Martinez-Garcia, E.2
Nguyen, H.3
Mullen, A.R.4
Dufour, E.5
Sudarshan, S.6
-
219
-
-
84905513649
-
Prolyl-4-hydroxylase 2 enhances hypoxia-induced glioblastoma cell death by regulating the gene expression of hypoxia-inducible factor-a
-
Sun W, Jelkmann W, Depping R: Prolyl-4-hydroxylase 2 enhances hypoxia-induced glioblastoma cell death by regulating the gene expression of hypoxia-inducible factor-a. Cell Death Dis 5:e1322, 2014
-
(2014)
Cell Death Dis
, vol.5
-
-
Sun, W.1
Jelkmann, W.2
Depping, R.3
-
220
-
-
0031688165
-
Tumour hypoxia and vascular density as predictors of metastasis in squamous cell carcinoma of the uterine cervix
-
Sundfør K, Lyng H, Rofstad EK: Tumour hypoxia and vascular density as predictors of metastasis in squamous cell carcinoma of the uterine cervix. Br J Cancer 78:822-827, 1998
-
(1998)
Br J Cancer
, vol.78
, pp. 822-827
-
-
Sundfør, K.1
Lyng, H.2
Rofstad, E.K.3
-
221
-
-
84883271078
-
Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology
-
Sutendra G, Michelakis ED: Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology. Front Oncol 3:38, 2013
-
(2013)
Front Oncol
, vol.3
, pp. 38
-
-
Sutendra, G.1
Michelakis, E.D.2
-
222
-
-
19944431335
-
Identification of a novel small-molecule inhibitor of the hypoxia-inducible factor 1 pathway
-
Tan C, de Noronha RG, Roecker AJ, Pyrzynska B, Khwaja F, Zhang Z, et al: Identification of a novel small-molecule inhibitor of the hypoxia-inducible factor 1 pathway. Cancer Res 65:605-612, 2005
-
(2005)
Cancer Res
, vol.65
, pp. 605-612
-
-
Tan, C.1
de Noronha, R.G.2
Roecker, A.J.3
Pyrzynska, B.4
Khwaja, F.5
Zhang, Z.6
-
223
-
-
3142534607
-
Hypoxia-inducible factor 1 alpha expression correlates with angiogenesis and unfavorable prognosis in bladder cancer
-
Theodoropoulos VE, Lazaris ACh, Sofras F, Gerzelis I, Tsoukala V, Ghikonti I, et al: Hypoxia-inducible factor 1 alpha expression correlates with angiogenesis and unfavorable prognosis in bladder cancer. Eur Urol 46:200-208, 2004
-
(2004)
Eur Urol
, vol.46
, pp. 200-208
-
-
Theodoropoulos, V.E.1
Lazaris, A.C.2
Sofras, F.3
Gerzelis, I.4
Tsoukala, V.5
Ghikonti, I.6
-
224
-
-
2342422295
-
Vascular microenvironment in gliomas
-
Vajkoczy P, Menger MD: Vascular microenvironment in gliomas. Cancer Treat Res 117:249-262, 2004
-
(2004)
Cancer Treat Res
, vol.117
, pp. 249-262
-
-
Vajkoczy, P.1
Menger, M.D.2
-
225
-
-
0029397625
-
Cytokines and tumors of the central nervous system
-
Van Meir EG: Cytokines and tumors of the central nervous system. Glia 15:264-288, 1995
-
(1995)
Glia
, vol.15
, pp. 264-288
-
-
Van Meir, E.G.1
-
226
-
-
84891273707
-
Combined targeting of PDK1 and EGFR triggers regression of glioblastoma by reversing the Warburg effect
-
Velpula KK, Bhasin A, Asuthkar S, Tsung AJ: Combined targeting of PDK1 and EGFR triggers regression of glioblastoma by reversing the Warburg effect. Cancer Res 73:7277-7289, 2013
-
(2013)
Cancer Res
, vol.73
, pp. 7277-7289
-
-
Velpula, K.K.1
Bhasin, A.2
Asuthkar, S.3
Tsung, A.J.4
-
227
-
-
59649105538
-
Camptothecins: a SAR/QSAR study
-
Verma RP, Hansch C: Camptothecins: a SAR/QSAR study. Chem Rev 109:213-235, 2009
-
(2009)
Chem Rev
, vol.109
, pp. 213-235
-
-
Verma, R.P.1
Hansch, C.2
-
228
-
-
84899486982
-
Hsp90 inhibition enhances PI-3 kinase inhibition and radiosensitivity in glioblastoma
-
Wachsberger PR, Lawrence YR, Liu Y, Rice B, Feo N, Leiby B, et al: Hsp90 inhibition enhances PI-3 kinase inhibition and radiosensitivity in glioblastoma. J Cancer Res Clin Oncol 140:573-582, 2014
-
(2014)
J Cancer Res Clin Oncol
, vol.140
, pp. 573-582
-
-
Wachsberger, P.R.1
Lawrence, Y.R.2
Liu, Y.3
Rice, B.4
Feo, N.5
Leiby, B.6
-
229
-
-
0034652620
-
High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers
-
Walenta S, Wetterling M, Lehrke M, Schwickert G, Sundfør K, Rofstad EK, et al: High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers. Cancer Res 60:916-921, 2000
-
(2000)
Cancer Res
, vol.60
, pp. 916-921
-
-
Walenta, S.1
Wetterling, M.2
Lehrke, M.3
Schwickert, G.4
Sundfør, K.5
Rofstad, E.K.6
-
230
-
-
33744829237
-
CCI-779 inhibits rhabdomyosarcoma xenograft growth by an antiangiogenic mechanism linked to the targeting of mTOR/Hif-1alpha/ VEGF signaling
-
Wan X, Shen N, Mendoza A, Khanna C, Helman LJ: CCI-779 inhibits rhabdomyosarcoma xenograft growth by an antiangiogenic mechanism linked to the targeting of mTOR/Hif-1alpha/ VEGF signaling. Neoplasia 8:394-401, 2006
-
(2006)
Neoplasia
, vol.8
, pp. 394-401
-
-
Wan, X.1
Shen, N.2
Mendoza, A.3
Khanna, C.4
Helman, L.J.5
-
231
-
-
84899874531
-
The role of factor inhibiting HIF (FIH-1) in inhibiting HIF-1 transcriptional activity in glioblastoma multiforme
-
Wang E, Zhang C, Polavaram N, Liu F, Wu G, Schroeder MA, et al: The role of factor inhibiting HIF (FIH-1) in inhibiting HIF-1 transcriptional activity in glioblastoma multiforme. PLoS ONE 9:e86102, 2014
-
(2014)
PLoS ONE
, vol.9
-
-
Wang, E.1
Zhang, C.2
Polavaram, N.3
Liu, F.4
Wu, G.5
Schroeder, M.A.6
-
232
-
-
80055009016
-
Downregulation of receptor for activated C-kinase 1 (RACK1) suppresses tumor growth by inhibiting tumor cell proliferation and tumor-associated angiogenesis
-
Wang F, Osawa T, Tsuchida R, Yuasa Y, Shibuya M: Downregulation of receptor for activated C-kinase 1 (RACK1) suppresses tumor growth by inhibiting tumor cell proliferation and tumor-associated angiogenesis. Cancer Sci 102:2007-2013, 2011
-
(2011)
Cancer Sci
, vol.102
, pp. 2007-2013
-
-
Wang, F.1
Osawa, T.2
Tsuchida, R.3
Yuasa, Y.4
Shibuya, M.5
-
233
-
-
0029051439
-
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
-
Wang GL, Jiang BH, Rue EA, Semenza GL: Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci U S A 92:5510-5514, 1995
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 5510-5514
-
-
Wang, G.L.1
Jiang, B.H.2
Rue, E.A.3
Semenza, G.L.4
-
234
-
-
84897380818
-
Prognosis value of HIF-1a expression in patients with non-small cell lung cancer
-
Wang Q, Hu DF, Rui Y, Jiang AB, Liu ZL, Huang LN: Prognosis value of HIF-1a expression in patients with non-small cell lung cancer. Gene 541:69-74, 2014
-
(2014)
Gene
, vol.541
, pp. 69-74
-
-
Wang, Q.1
Hu, D.F.2
Rui, Y.3
Jiang, A.B.4
Liu, Z.L.5
Huang, L.N.6
-
235
-
-
12444279265
-
On the origin of cancer cells
-
Warburg O: On the origin of cancer cells. Science 123:309-314, 1956
-
(1956)
Science
, vol.123
, pp. 309-314
-
-
Warburg, O.1
-
236
-
-
74549159014
-
The c-Met receptor tyrosine kinase inhibitor MP470 radiosensitizes glioblastoma cells
-
Welsh JW, Mahadevan D, Ellsworth R, Cooke L, Bearss D, Stea B: The c-Met receptor tyrosine kinase inhibitor MP470 radiosensitizes glioblastoma cells. Radiat Oncol 4:69, 2009
-
(2009)
Radiat Oncol
, vol.4
, pp. 69
-
-
Welsh, J.W.1
Mahadevan, D.2
Ellsworth, R.3
Cooke, L.4
Bearss, D.5
Stea, B.6
-
237
-
-
0142144338
-
The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1alpha and vascular endothelial growth factor formation
-
Welsh SJ, Williams RR, Birmingham A, Newman DJ, Kirkpatrick DL, Powis G: The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1alpha and vascular endothelial growth factor formation. Mol Cancer Ther 2:235-243, 2003
-
(2003)
Mol Cancer Ther
, vol.2
, pp. 235-243
-
-
Welsh, S.J.1
Williams, R.R.2
Birmingham, A.3
Newman, D.J.4
Kirkpatrick, D.L.5
Powis, G.6
-
238
-
-
84922572782
-
Local delivery of cancer-cell glycolytic inhibitors in highgrade glioma
-
[epub ahead of print]
-
Wicks RT, Azadi J, Mangraviti A, Zhang I, Hwang L, Joshi A, et al: Local delivery of cancer-cell glycolytic inhibitors in highgrade glioma. Neuro Oncol [epub ahead of print], 2014
-
(2014)
Neuro Oncol
-
-
Wicks, R.T.1
Azadi, J.2
Mangraviti, A.3
Zhang, I.4
Hwang, L.5
Joshi, A.6
-
239
-
-
0024315240
-
Drug resistance in Chinese hamster ovary cells during recovery from severe hypoxia
-
Wilson RE, Keng PC, Sutherland RM: Drug resistance in Chinese hamster ovary cells during recovery from severe hypoxia. J Natl Cancer Inst 81:1235-1240, 1989
-
(1989)
J Natl Cancer Inst
, vol.81
, pp. 1235-1240
-
-
Wilson, R.E.1
Keng, P.C.2
Sutherland, R.M.3
-
240
-
-
79958015593
-
Targeting metabolic remodeling in glioblastoma multiforme
-
Wolf A, Agnihotri S, Guha A: Targeting metabolic remodeling in glioblastoma multiforme. Oncotarget 1:552-562, 2010
-
(2010)
Oncotarget
, vol.1
, pp. 552-562
-
-
Wolf, A.1
Agnihotri, S.2
Guha, A.3
-
241
-
-
79951699777
-
Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme
-
Wolf A, Agnihotri S, Micallef J, Mukherjee J, Sabha N, Cairns R, et al: Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme. J Exp Med 208:313-326, 2011
-
(2011)
J Exp Med
, vol.208
, pp. 313-326
-
-
Wolf, A.1
Agnihotri, S.2
Micallef, J.3
Mukherjee, J.4
Sabha, N.5
Cairns, R.6
-
242
-
-
79961127669
-
Developmental profile and regulation of the glycolytic enzyme hexokinase 2 in normal brain and glioblastoma multiforme
-
Wolf A, Agnihotri S, Munoz D, Guha A: Developmental profile and regulation of the glycolytic enzyme hexokinase 2 in normal brain and glioblastoma multiforme. Neurobiol Dis 44:84-91, 2011
-
(2011)
Neurobiol Dis
, vol.44
, pp. 84-91
-
-
Wolf, A.1
Agnihotri, S.2
Munoz, D.3
Guha, A.4
-
243
-
-
84862818535
-
Recent advances in hypoxia-inducible factor (HIF)-1 inhibitors
-
Xia Y, Choi HK, Lee K: Recent advances in hypoxia-inducible factor (HIF)-1 inhibitors. Eur J Med Chem 49:24-40, 2012
-
(2012)
Eur J Med Chem
, vol.49
, pp. 24-40
-
-
Xia, Y.1
Choi, H.K.2
Lee, K.3
-
244
-
-
12544256565
-
Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia
-
Xu RH, Pelicano H, Zhou Y, Carew JS, Feng L, Bhalla KN, et al: Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia. Cancer Res 65:613-621, 2005
-
(2005)
Cancer Res
, vol.65
, pp. 613-621
-
-
Xu, R.H.1
Pelicano, H.2
Zhou, Y.3
Carew, J.S.4
Feng, L.5
Bhalla, K.N.6
-
245
-
-
84872266344
-
Small ubiquitin-like modifier 1-3 conjugation [corrected] is activated in human astrocytic brain tumors and is required for glioblastoma cell survival
-
(Erratum in Cancer Sci 104:70-77, 2013)
-
Yang W, Wang L, Roehn G, Pearlstein RD, Ali-Osman F, Pan H, et al: Small ubiquitin-like modifier 1-3 conjugation [corrected] is activated in human astrocytic brain tumors and is required for glioblastoma cell survival. Cancer Sci 104:70-77, 2013 (Erratum in Cancer Sci 104:70-77, 2013)
-
(2013)
Cancer Sci
, vol.104
, pp. 70-77
-
-
Yang, W.1
Wang, L.2
Roehn, G.3
Pearlstein, R.D.4
Ali-Osman, F.5
Pan, H.6
-
246
-
-
31544469773
-
Amphotericin B blunts erythropoietin response to hypoxia by reinforcing FIH-mediated repression of HIF-1
-
Yeo EJ, Ryu JH, Cho YS, Chun YS, Huang LE, Kim MS, et al: Amphotericin B blunts erythropoietin response to hypoxia by reinforcing FIH-mediated repression of HIF-1. Blood 107:916-923, 2006
-
(2006)
Blood
, vol.107
, pp. 916-923
-
-
Yeo, E.J.1
Ryu, J.H.2
Cho, Y.S.3
Chun, Y.S.4
Huang, L.E.5
Kim, M.S.6
-
247
-
-
84866424379
-
Arylsulfonamide KCN1 inhibits in vivo glioma growth and interferes with HIF signaling by disrupting HIF-1a interaction with cofactors p300/CBP
-
Yin S, Kaluz S, Devi NS, Jabbar AA, de Noronha RG, Mun J, et al: Arylsulfonamide KCN1 inhibits in vivo glioma growth and interferes with HIF signaling by disrupting HIF-1a interaction with cofactors p300/CBP. Clin Cancer Res 18:6623-6633, 2012
-
(2012)
Clin Cancer Res
, vol.18
, pp. 6623-6633
-
-
Yin, S.1
Kaluz, S.2
Devi, N.S.3
Jabbar, A.A.4
de Noronha, R.G.5
Mun, J.6
-
248
-
-
0034213146
-
Expression of hypoxia-inducible factor 1alpha in brain tumors: association with angiogenesis, invasion, and progression
-
Zagzag D, Zhong H, Scalzitti JM, Laughner E, Simons JW, Semenza GL: Expression of hypoxia-inducible factor 1alpha in brain tumors: association with angiogenesis, invasion, and progression. Cancer 88:2606-2618, 2000
-
(2000)
Cancer
, vol.88
, pp. 2606-2618
-
-
Zagzag, D.1
Zhong, H.2
Scalzitti, J.M.3
Laughner, E.4
Simons, J.W.5
Semenza, G.L.6
-
249
-
-
33646117271
-
Evidence that hypoxia-inducible factor-1 (HIF-1) mediates transcriptional activation of interleukin-1beta (IL-1beta) in astrocyte cultures
-
Zhang W, Petrovic JM, Callaghan D, Jones A, Cui H, Howlett C, et al: Evidence that hypoxia-inducible factor-1 (HIF-1) mediates transcriptional activation of interleukin-1beta (IL-1beta) in astrocyte cultures. J Neuroimmunol 174:63-73, 2006
-
(2006)
J Neuroimmunol
, vol.174
, pp. 63-73
-
-
Zhang, W.1
Petrovic, J.M.2
Callaghan, D.3
Jones, A.4
Cui, H.5
Howlett, C.6
-
250
-
-
84885173431
-
Melatonin antagonizes hypoxia-mediated glioblastoma cell migration and invasion via inhibition of HIF-1a
-
Zhang Y, Liu Q, Wang F, Ling EA, Liu S, Wang L, et al: Melatonin antagonizes hypoxia-mediated glioblastoma cell migration and invasion via inhibition of HIF-1a. J Pineal Res 55:121-130, 2013
-
(2013)
J Pineal Res
, vol.55
, pp. 121-130
-
-
Zhang, Y.1
Liu, Q.2
Wang, F.3
Ling, E.A.4
Liu, S.5
Wang, L.6
-
251
-
-
84876737635
-
miR-143 inhibits glycolysis and depletes stemness of glioblastoma stemlike cells
-
Zhao S, Liu H, Liu Y, Wu J, Wang C, Hou X, et al: miR-143 inhibits glycolysis and depletes stemness of glioblastoma stemlike cells. Cancer Lett 333:253-260, 2013
-
(2013)
Cancer Lett
, vol.333
, pp. 253-260
-
-
Zhao, S.1
Liu, H.2
Liu, Y.3
Wu, J.4
Wang, C.5
Hou, X.6
-
252
-
-
84860258307
-
B-elemene inhibits Hsp90/Raf-1 molecular complex inducing apoptosis of glioblastoma cells
-
Zhao YS, Zhu TZ, Chen YW, Yao YQ, Wu CM, Wei ZQ, et al: B-elemene inhibits Hsp90/Raf-1 molecular complex inducing apoptosis of glioblastoma cells. J Neurooncol 107:307-314, 2012
-
(2012)
J Neurooncol
, vol.107
, pp. 307-314
-
-
Zhao, Y.S.1
Zhu, T.Z.2
Chen, Y.W.3
Yao, Y.Q.4
Wu, C.M.5
Wei, Z.Q.6
-
253
-
-
0033571682
-
Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases
-
Zhong H, De Marzo AM, Laughner E, Lim M, Hilton DA, Zagzag D, et al: Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res 59:5830-5835, 1999
-
(1999)
Cancer Res
, vol.59
, pp. 5830-5835
-
-
Zhong, H.1
De Marzo, A.M.2
Laughner, E.3
Lim, M.4
Hilton, D.A.5
Zagzag, D.6
-
254
-
-
84901266379
-
Human rhomboid family-1 suppresses oxygen-independent degradation of hypoxia-inducible factor-1a in breast cancer
-
Zhou Z, Liu F, Zhang ZS, Shu F, Zheng Y, Fu L, et al: Human rhomboid family-1 suppresses oxygen-independent degradation of hypoxia-inducible factor-1a in breast cancer. Cancer Res 74:2719-2730, 2014
-
(2014)
Cancer Res
, vol.74
, pp. 2719-2730
-
-
Zhou, Z.1
Liu, F.2
Zhang, Z.S.3
Shu, F.4
Zheng, Y.5
Fu, L.6
-
255
-
-
77956572981
-
The novel Hsp90 inhibitor NXD30001 induces tumor regression in a genetically engineered mouse model of glioblastoma multiforme
-
Zhu H, Woolfenden S, Bronson RT, Jaffer ZM, Barluenga S, Winssinger N, et al: The novel Hsp90 inhibitor NXD30001 induces tumor regression in a genetically engineered mouse model of glioblastoma multiforme. Mol Cancer Ther 9:2618-2626, 2010
-
(2010)
Mol Cancer Ther
, vol.9
, pp. 2618-2626
-
-
Zhu, H.1
Woolfenden, S.2
Bronson, R.T.3
Jaffer, Z.M.4
Barluenga, S.5
Winssinger, N.6
-
256
-
-
0034050050
-
Loss of PTEN facilitates HIF-1-mediated gene expression
-
Zundel W, Schindler C, Haas-Kogan D, Koong A, Kaper F, Chen E, et al: Loss of PTEN facilitates HIF-1-mediated gene expression. Genes Dev 14:391-396, 2000
-
(2000)
Genes Dev
, vol.14
, pp. 391-396
-
-
Zundel, W.1
Schindler, C.2
Haas-Kogan, D.3
Koong, A.4
Kaper, F.5
Chen, E.6
-
257
-
-
84881261950
-
Dichloroacetate induces tumor-specific radiosensitivity in vitro but attenuates radiation-induced tumor growth delay in vivo
-
Zwicker F, Kirsner A, Peschke P, Roeder F, Debus J, Huber PE, et al: Dichloroacetate induces tumor-specific radiosensitivity in vitro but attenuates radiation-induced tumor growth delay in vivo. Strahlenther Onkol 189:684-692, 2013
-
(2013)
Strahlenther Onkol
, vol.189
, pp. 684-692
-
-
Zwicker, F.1
Kirsner, A.2
Peschke, P.3
Roeder, F.4
Debus, J.5
Huber, P.E.6
|