메뉴 건너뛰기




Volumn 37, Issue 6, 2014, Pages

Hypoxia-inducible factor-1 and associated upstream and downstream proteins in the pathophysiology and management of glioblastoma

Author keywords

Glioblastoma; Glycolysis; Hypoxia; Hypoxia inducible factor; Metabolism

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1;

EID: 84916935120     PISSN: None     EISSN: 10920684     Source Type: Journal    
DOI: 10.3171/2014.9.FOCUS14496     Document Type: Article
Times cited : (40)

References (257)
  • 1
    • 0036365052 scopus 로고    scopus 로고
    • In vivo targeting of SF/HGF and c-met expression via U1snRNA/ribozymes inhibits glioma growth and angiogenesis and promotes apoptosis
    • Abounader R, Lal B, Luddy C, Koe G, Davidson B, Rosen EM, et al: In vivo targeting of SF/HGF and c-met expression via U1snRNA/ribozymes inhibits glioma growth and angiogenesis and promotes apoptosis. FASEB J 16:108-110, 2002
    • (2002) FASEB J , vol.16 , pp. 108-110
    • Abounader, R.1    Lal, B.2    Luddy, C.3    Koe, G.4    Davidson, B.5    Rosen, E.M.6
  • 2
    • 0033568455 scopus 로고    scopus 로고
    • Reversion of human glioblastoma malignancy by U1 small nuclear RNA/ribozyme targeting of scatter factor/ hepatocyte growth factor and c-met expression
    • Abounader R, Ranganathan S, Lal B, Fielding K, Book A, Dietz H, et al: Reversion of human glioblastoma malignancy by U1 small nuclear RNA/ribozyme targeting of scatter factor/ hepatocyte growth factor and c-met expression. J Natl Cancer Inst 91:1548-1556, 1999
    • (1999) J Natl Cancer Inst , vol.91 , pp. 1548-1556
    • Abounader, R.1    Ranganathan, S.2    Lal, B.3    Fielding, K.4    Book, A.5    Dietz, H.6
  • 3
    • 33749499603 scopus 로고    scopus 로고
    • Tumor stromal-derived factor-1 recruits vascular progenitors to mitotic neovasculature, where microenvironment influences their differentiated phenotypes
    • Aghi M, Cohen KS, Klein RJ, Scadden DT, Chiocca EA: Tumor stromal-derived factor-1 recruits vascular progenitors to mitotic neovasculature, where microenvironment influences their differentiated phenotypes. Cancer Res 66:9054-9064, 2006
    • (2006) Cancer Res , vol.66 , pp. 9054-9064
    • Aghi, M.1    Cohen, K.S.2    Klein, R.J.3    Scadden, D.T.4    Chiocca, E.A.5
  • 4
    • 67649446851 scopus 로고    scopus 로고
    • SNS-032 prevents hypoxia-mediated glioblastoma cell invasion by inhibiting hypoxia inducible factor-1alpha expression
    • Ali MA, Reis A, Ding LH, Story MD, Habib AA, Chattopadhyay A, et al: SNS-032 prevents hypoxia-mediated glioblastoma cell invasion by inhibiting hypoxia inducible factor-1alpha expression. Int J Oncol 34:1051-1060, 2009
    • (2009) Int J Oncol , vol.34 , pp. 1051-1060
    • Ali, M.A.1    Reis, A.2    Ding, L.H.3    Story, M.D.4    Habib, A.A.5    Chattopadhyay, A.6
  • 5
    • 0038323916 scopus 로고    scopus 로고
    • Hypoxia promotes murine bone-marrow-derived stromal cell migration and tube formation
    • Annabi B, Lee YT, Turcotte S, Naud E, Desrosiers RR, Champagne M, et al: Hypoxia promotes murine bone-marrow-derived stromal cell migration and tube formation. Stem Cells 21:337-347, 2003
    • (2003) Stem Cells , vol.21 , pp. 337-347
    • Annabi, B.1    Lee, Y.T.2    Turcotte, S.3    Naud, E.4    Desrosiers, R.R.5    Champagne, M.6
  • 7
    • 0033416032 scopus 로고    scopus 로고
    • Stimulation of glucose transport by hypoxia: signals and mechanisms
    • Behrooz A, Ismail-Beigi F: Stimulation of glucose transport by hypoxia: signals and mechanisms. News Physiol Sci 14:105-110, 1999
    • (1999) News Physiol Sci , vol.14 , pp. 105-110
    • Behrooz, A.1    Ismail-Beigi, F.2
  • 8
    • 47949099628 scopus 로고    scopus 로고
    • Modes of resistance to anti-angiogenic therapy
    • Bergers G, Hanahan D: Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer 8:592-603, 2008
    • (2008) Nat Rev Cancer , vol.8 , pp. 592-603
    • Bergers, G.1    Hanahan, D.2
  • 9
    • 24744460523 scopus 로고    scopus 로고
    • Arrest-defective-1 protein, an acetyltransferase, does not alter stability of hypoxia-inducible factor (HIF)-1alpha and is not induced by hypoxia or HIF
    • Bilton R, Mazure N, Trottier E, Hattab M, Déry MA, Richard DE, et al: Arrest-defective-1 protein, an acetyltransferase, does not alter stability of hypoxia-inducible factor (HIF)-1alpha and is not induced by hypoxia or HIF. J Biol Chem 280:31132-31140, 2005
    • (2005) J Biol Chem , vol.280 , pp. 31132-31140
    • Bilton, R.1    Mazure, N.2    Trottier, E.3    Hattab, M.4    Déry, M.A.5    Richard, D.E.6
  • 10
    • 0020326952 scopus 로고
    • Intracranial tumors: response and resistance to therapeutic endeavors, 1970-1980
    • Bloom HJ: Intracranial tumors: response and resistance to therapeutic endeavors, 1970-1980. Int J Radiat Oncol Biol Phys 8:1083-1113, 1982
    • (1982) Int J Radiat Oncol Biol Phys , vol.8 , pp. 1083-1113
    • Bloom, H.J.1
  • 11
    • 0041382820 scopus 로고    scopus 로고
    • The hypoxic response of tumors is dependent on their microenvironment
    • Blouw B, Song H, Tihan T, Bosze J, Ferrara N, Gerber HP, et al: The hypoxic response of tumors is dependent on their microenvironment. Cancer Cell 4:133-146, 2003
    • (2003) Cancer Cell , vol.4 , pp. 133-146
    • Blouw, B.1    Song, H.2    Tihan, T.3    Bosze, J.4    Ferrara, N.5    Gerber, H.P.6
  • 12
    • 13444283313 scopus 로고    scopus 로고
    • Ras inhibition in glioblastoma down-regulates hypoxia-inducible factor-1alpha, causing glycolysis shutdown and cell death
    • Blum R, Jacob-Hirsch J, Amariglio N, Rechavi G, Kloog Y: Ras inhibition in glioblastoma down-regulates hypoxia-inducible factor-1alpha, causing glycolysis shutdown and cell death. Cancer Res 65:999-1006, 2005
    • (2005) Cancer Res , vol.65 , pp. 999-1006
    • Blum, R.1    Jacob-Hirsch, J.2    Amariglio, N.3    Rechavi, G.4    Kloog, Y.5
  • 13
    • 84901012573 scopus 로고    scopus 로고
    • Celastrol targets proteostasis and acts synergistically with a heat-shock protein 90 inhibitor to kill human glioblastoma cells
    • Boridy S, Le PU, Petrecca K, Maysinger D: Celastrol targets proteostasis and acts synergistically with a heat-shock protein 90 inhibitor to kill human glioblastoma cells. Cell Death Dis 5:e1216, 2014
    • (2014) Cell Death Dis , vol.5
    • Boridy, S.1    Le, P.U.2    Petrecca, K.3    Maysinger, D.4
  • 14
    • 0842325802 scopus 로고    scopus 로고
    • Pseudopalisades in glioblastoma are hypoxic, express extracellular matrix proteases, and are formed by an actively migrating cell population
    • Brat DJ, Castellano-Sanchez AA, Hunter SB, Pecot M, Cohen C, Hammond EH, et al: Pseudopalisades in glioblastoma are hypoxic, express extracellular matrix proteases, and are formed by an actively migrating cell population. Cancer Res 64:920-927, 2004
    • (2004) Cancer Res , vol.64 , pp. 920-927
    • Brat, D.J.1    Castellano-Sanchez, A.A.2    Hunter, S.B.3    Pecot, M.4    Cohen, C.5    Hammond, E.H.6
  • 15
    • 0037501724 scopus 로고    scopus 로고
    • Malignant glioma physiology: cellular response to hypoxia and its role in tumor progression
    • Brat DJ, Mapstone TB: Malignant glioma physiology: cellular response to hypoxia and its role in tumor progression. Ann Intern Med 138:659-668, 2003
    • (2003) Ann Intern Med , vol.138 , pp. 659-668
    • Brat, D.J.1    Mapstone, T.B.2
  • 16
    • 77958603109 scopus 로고    scopus 로고
    • Radiosensitization of glioma cells by modulation of Met signalling with the hepatocyte growth factor neutralizing antibody, AMG102
    • Buchanan IM, Scott T, Tandle AT, Burgan WE, Burgess TL, Tofilon PJ, et al: Radiosensitization of glioma cells by modulation of Met signalling with the hepatocyte growth factor neutralizing antibody, AMG102. J Cell Mol Med 15:1999-2006, 2011
    • (2011) J Cell Mol Med , vol.15 , pp. 1999-2006
    • Buchanan, I.M.1    Scott, T.2    Tandle, A.T.3    Burgan, W.E.4    Burgess, T.L.5    Tofilon, P.J.6
  • 17
    • 32944467848 scopus 로고    scopus 로고
    • Fully human monoclonal antibodies to hepatocyte growth factor with therapeutic potential against hepatocyte growth factor/c-Met-dependent human tumors
    • Burgess T, Coxon A, Meyer S, Sun J, Rex K, Tsuruda T, et al: Fully human monoclonal antibodies to hepatocyte growth factor with therapeutic potential against hepatocyte growth factor/c-Met-dependent human tumors. Cancer Res 66:1721-1729, 2006
    • (2006) Cancer Res , vol.66 , pp. 1721-1729
    • Burgess, T.1    Coxon, A.2    Meyer, S.3    Sun, J.4    Rex, K.5    Tsuruda, T.6
  • 18
    • 0033551070 scopus 로고    scopus 로고
    • New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
    • Cantley LC, Neel BG: New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc Natl Acad Sci U S A 96:4240-4245, 1999
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 4240-4245
    • Cantley, L.C.1    Neel, B.G.2
  • 19
    • 33846270366 scopus 로고    scopus 로고
    • Glucose uptake inhibitor sensitizes cancer cells to daunorubicin and overcomes drug resistance in hypoxia
    • Cao X, Fang L, Gibbs S, Huang Y, Dai Z, Wen P, et al: Glucose uptake inhibitor sensitizes cancer cells to daunorubicin and overcomes drug resistance in hypoxia. Cancer Chemother Pharmacol 59:495-505, 2007
    • (2007) Cancer Chemother Pharmacol , vol.59 , pp. 495-505
    • Cao, X.1    Fang, L.2    Gibbs, S.3    Huang, Y.4    Dai, Z.5    Wen, P.6
  • 20
    • 79958706977 scopus 로고    scopus 로고
    • RACK1 promotes breast carcinoma migration/metastasis via activation of the RhoA/Rho kinase pathway
    • Cao XX, Xu JD, Xu JW, Liu XL, Cheng YY, Li QQ, et al: RACK1 promotes breast carcinoma migration/metastasis via activation of the RhoA/Rho kinase pathway. Breast Cancer Res Treat 126:555-563, 2011
    • (2011) Breast Cancer Res Treat , vol.126 , pp. 555-563
    • Cao, X.X.1    Xu, J.D.2    Xu, J.W.3    Liu, X.L.4    Cheng, Y.Y.5    Li, Q.Q.6
  • 21
    • 0032581277 scopus 로고    scopus 로고
    • Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
    • (Erratum in Nature 395:525, 1998)
    • Carmeliet P, Dor Y, Herbert JM, Fukumura D, Brusselmans K, Dewerchin M, et al: Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 394:485-490, 1998 (Erratum in Nature 395:525, 1998)
    • (1998) Nature , vol.394 , pp. 485-490
    • Carmeliet, P.1    Dor, Y.2    Herbert, J.M.3    Fukumura, D.4    Brusselmans, K.5    Dewerchin, M.6
  • 23
    • 3042823868 scopus 로고    scopus 로고
    • The prognostic significance of phosphatidylinositol 3-kinase pathway activation in human gliomas
    • Chakravarti A, Zhai G, Suzuki Y, Sarkesh S, Black PM, Muzikansky A, et al: The prognostic significance of phosphatidylinositol 3-kinase pathway activation in human gliomas. J Clin Oncol 22:1926-1933, 2004
    • (2004) J Clin Oncol , vol.22 , pp. 1926-1933
    • Chakravarti, A.1    Zhai, G.2    Suzuki, Y.3    Sarkesh, S.4    Black, P.M.5    Muzikansky, A.6
  • 24
    • 0028805059 scopus 로고
    • Suppression of growth of renal carcinoma cells by the von Hippel-Lindau tumor suppressor gene
    • Chen F, Kishida T, Duh FM, Renbaum P, Orcutt ML, Schmidt L, et al: Suppression of growth of renal carcinoma cells by the von Hippel-Lindau tumor suppressor gene. Cancer Res 55:4804-4807, 1995
    • (1995) Cancer Res , vol.55 , pp. 4804-4807
    • Chen, F.1    Kishida, T.2    Duh, F.M.3    Renbaum, P.4    Orcutt, M.L.5    Schmidt, L.6
  • 25
    • 84864717408 scopus 로고    scopus 로고
    • VHL regulates the effects of miR-23b on glioma survival and invasion via suppression of HIF-1a/VEGF and b-catenin/Tcf-4 signaling
    • Chen L, Han L, Zhang K, Shi Z, Zhang J, Zhang A, et al: VHL regulates the effects of miR-23b on glioma survival and invasion via suppression of HIF-1a/VEGF and b-catenin/Tcf-4 signaling. Neuro Oncol 14:1026-1036, 2012
    • (2012) Neuro Oncol , vol.14 , pp. 1026-1036
    • Chen, L.1    Han, L.2    Zhang, K.3    Shi, Z.4    Zhang, J.5    Zhang, A.6
  • 26
    • 61349201437 scopus 로고    scopus 로고
    • In vitro angiogenesis by human umbilical vein endothelial cells (HUVEC) induced by three-dimensional co-culture with glioblastoma cells
    • Chen Z, Htay A, Dos Santos W, Gillies GT, Fillmore HL, Sholley MM, et al: In vitro angiogenesis by human umbilical vein endothelial cells (HUVEC) induced by three-dimensional co-culture with glioblastoma cells. J Neurooncol 92:121-128, 2009
    • (2009) J Neurooncol , vol.92 , pp. 121-128
    • Chen, Z.1    Htay, A.2    Dos Santos, W.3    Gillies, G.T.4    Fillmore, H.L.5    Sholley, M.M.6
  • 28
    • 77956399348 scopus 로고    scopus 로고
    • HIF1-alpha functions as a tumor promoter in cancer associated fibroblasts, and as a tumor suppressor in breast cancer cells: autophagy drives compartment-specific oncogenesis
    • Chiavarina B, Whitaker-Menezes D, Migneco G, Martinez-Outschoorn UE, Pavlides S, Howell A, et al: HIF1-alpha functions as a tumor promoter in cancer associated fibroblasts, and as a tumor suppressor in breast cancer cells: autophagy drives compartment-specific oncogenesis. Cell Cycle 9:3534-3551, 2010
    • (2010) Cell Cycle , vol.9 , pp. 3534-3551
    • Chiavarina, B.1    Whitaker-Menezes, D.2    Migneco, G.3    Martinez-Outschoorn, U.E.4    Pavlides, S.5    Howell, A.6
  • 29
    • 84894231936 scopus 로고    scopus 로고
    • A ROS/STAT3/HIF-1a signaling cascade mediates EGFinduced TWIST1 expression and prostate cancer cell invasion
    • Cho KH, Choi MJ, Jeong KJ, Kim JJ, Hwang MH, Shin SC, et al: A ROS/STAT3/HIF-1a signaling cascade mediates EGFinduced TWIST1 expression and prostate cancer cell invasion. Prostate 74:528-536, 2014
    • (2014) Prostate , vol.74 , pp. 528-536
    • Cho, K.H.1    Choi, M.J.2    Jeong, K.J.3    Kim, J.J.4    Hwang, M.H.5    Shin, S.C.6
  • 30
    • 0038615946 scopus 로고    scopus 로고
    • Analysis of the phosphatidylinositol 3'-kinase signaling pathway in glioblastoma patients in vivo
    • Choe G, Horvath S, Cloughesy TF, Crosby K, Seligson D, Palotie A, et al: Analysis of the phosphatidylinositol 3'-kinase signaling pathway in glioblastoma patients in vivo. Cancer Res 63:2742-2746, 2003
    • (2003) Cancer Res , vol.63 , pp. 2742-2746
    • Choe, G.1    Horvath, S.2    Cloughesy, T.F.3    Crosby, K.4    Seligson, D.5    Palotie, A.6
  • 31
    • 79960962234 scopus 로고    scopus 로고
    • HIF-1a stabilization by mitochondrial ROS promotes Met-dependent invasive growth and vasculogenic mimicry in melanoma cells
    • Comito G, Calvani M, Giannoni E, Bianchini F, Calorini L, Torre E, et al: HIF-1a stabilization by mitochondrial ROS promotes Met-dependent invasive growth and vasculogenic mimicry in melanoma cells. Free Radic Biol Med 51:893-904, 2011
    • (2011) Free Radic Biol Med , vol.51 , pp. 893-904
    • Comito, G.1    Calvani, M.2    Giannoni, E.3    Bianchini, F.4    Calorini, L.5    Torre, E.6
  • 33
    • 0031059664 scopus 로고    scopus 로고
    • Exposure to hypoxia, glucose starvation and acidosis: effect on invasive capacity of murine tumor cells and correlation with cathepsin (L + B) secretion
    • Cuvier C, Jang A, Hill RP: Exposure to hypoxia, glucose starvation and acidosis: effect on invasive capacity of murine tumor cells and correlation with cathepsin (L + B) secretion. Clin Exp Metastasis 15:19-25, 1997
    • (1997) Clin Exp Metastasis , vol.15 , pp. 19-25
    • Cuvier, C.1    Jang, A.2    Hill, R.P.3
  • 34
    • 84922996291 scopus 로고    scopus 로고
    • ML309: a potent inhibitor of R132H mutant IDH1 capable of reducing 2-hydroxyglutarate production in U87 MG glioblastoma cells
    • Bethesda, MD: National Center for Biotechnology Information, 2010
    • Davis M, Pragani R, Popovici-Muller J, Gross S, Thorne N, Salituro F, et al: ML309: a potent inhibitor of R132H mutant IDH1 capable of reducing 2-hydroxyglutarate production in U87 MG glioblastoma cells, in Probe Reports from the NIH Molecular Libraries Program. Bethesda, MD: National Center for Biotechnology Information, 2010
    • Probe Reports from the NIH Molecular Libraries Program
    • Davis, M.1    Pragani, R.2    Popovici-Muller, J.3    Gross, S.4    Thorne, N.5    Salituro, F.6
  • 35
    • 84901020086 scopus 로고    scopus 로고
    • Biochemical, cellular, and biophysical characterization of a potent inhibitor of mutant isocitrate dehydrogenase IDH1
    • Davis MI, Gross S, Shen M, Straley KS, Pragani R, Lea WA, et al: Biochemical, cellular, and biophysical characterization of a potent inhibitor of mutant isocitrate dehydrogenase IDH1. J Biol Chem 289:13717-13725, 2014
    • (2014) J Biol Chem , vol.289 , pp. 13717-13725
    • Davis, M.I.1    Gross, S.2    Shen, M.3    Straley, K.S.4    Pragani, R.5    Lea, W.A.6
  • 36
  • 37
    • 9444226473 scopus 로고    scopus 로고
    • SDF-1 involvement in endothelial phenotype and ischemia-induced recruitment of bone marrow progenitor cells
    • De Falco E, Porcelli D, Torella AR, Straino S, Iachininoto MG, Orlandi A, et al: SDF-1 involvement in endothelial phenotype and ischemia-induced recruitment of bone marrow progenitor cells. Blood 104:3472-3482, 2004
    • (2004) Blood , vol.104 , pp. 3472-3482
    • De Falco, E.1    Porcelli, D.2    Torella, A.R.3    Straino, S.4    Iachininoto, M.G.5    Orlandi, A.6
  • 39
    • 39849102836 scopus 로고    scopus 로고
    • HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion
    • Du R, Lu KV, Petritsch C, Liu P, Ganss R, Passegué E, et al: HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell 13:206-220, 2008
    • (2008) Cancer Cell , vol.13 , pp. 206-220
    • Du, R.1    Lu, K.V.2    Petritsch, C.3    Liu, P.4    Ganss, R.5    Passegué, E.6
  • 40
    • 84875395513 scopus 로고    scopus 로고
    • Antitumor activity of dichloroacetate on C6 glioma cell: in vitro and in vivo evaluation
    • Duan Y, Zhao X, Ren W, Wang X, Yu KF, Li D, et al: Antitumor activity of dichloroacetate on C6 glioma cell: in vitro and in vivo evaluation. Onco Targets Ther 6:189-198, 2013
    • (2013) Onco Targets Ther , vol.6 , pp. 189-198
    • Duan, Y.1    Zhao, X.2    Ren, W.3    Wang, X.4    Yu, K.F.5    Li, D.6
  • 41
    • 34250340883 scopus 로고    scopus 로고
    • Hypoxia can induce c-Met expression in glioma cells and enhance SF/HGF-induced cell migration
    • Eckerich C, Zapf S, Fillbrandt R, Loges S, Westphal M, Lamszus K: Hypoxia can induce c-Met expression in glioma cells and enhance SF/HGF-induced cell migration. Int J Cancer 121:276-283, 2007
    • (2007) Int J Cancer , vol.121 , pp. 276-283
    • Eckerich, C.1    Zapf, S.2    Fillbrandt, R.3    Loges, S.4    Westphal, M.5    Lamszus, K.6
  • 42
    • 83555168279 scopus 로고    scopus 로고
    • D-amino acid oxidase gene therapy sensitizes glioma cells to the antiglycolytic effect of 3-bromopyruvate
    • El Sayed SM, Abou El-Magd RM, Shishido Y, Chung SP, Sakai T, Watanabe H, et al: D-amino acid oxidase gene therapy sensitizes glioma cells to the antiglycolytic effect of 3-bromopyruvate. Cancer Gene Ther 19:1-18, 2012
    • (2012) Cancer Gene Ther , vol.19 , pp. 1-18
    • El Sayed, S.M.1    Abou El-Magd, R.M.2    Shishido, Y.3    Chung, S.P.4    Sakai, T.5    Watanabe, H.6
  • 43
    • 84858749705 scopus 로고    scopus 로고
    • 3-Bromopyruvate antagonizes effects of lactate and pyruvate, synergizes with citrate and exerts novel antiglioma effects
    • El Sayed SM, El-Magd RM, Shishido Y, Chung SP, Diem TH, Sakai T, et al: 3-Bromopyruvate antagonizes effects of lactate and pyruvate, synergizes with citrate and exerts novel antiglioma effects. J Bioenerg Biomembr 44:61-79, 2012
    • (2012) J Bioenerg Biomembr , vol.44 , pp. 61-79
    • El Sayed, S.M.1    El-Magd, R.M.2    Shishido, Y.3    Chung, S.P.4    Diem, T.H.5    Sakai, T.6
  • 44
    • 84866645248 scopus 로고    scopus 로고
    • D-Amino acid oxidase-induced oxidative stress, 3-bromopyruvate and citrate inhibit angiogenesis, exhibiting potent anticancer effects
    • El Sayed SM, El-Magd RM, Shishido Y, Yorita K, Chung SP, Tran DH, et al: D-Amino acid oxidase-induced oxidative stress, 3-bromopyruvate and citrate inhibit angiogenesis, exhibiting potent anticancer effects. J Bioenerg Biomembr 44:513-523, 2012
    • (2012) J Bioenerg Biomembr , vol.44 , pp. 513-523
    • El Sayed, S.M.1    El-Magd, R.M.2    Shishido, Y.3    Yorita, K.4    Chung, S.P.5    Tran, D.H.6
  • 45
    • 37249067628 scopus 로고    scopus 로고
    • Glut-1 as a therapeutic target: increased chemoresistance and HIF-1-independent link with cell turnover is revealed through COMPARE analysis and metabolomic studies
    • Evans A, Bates V, Troy H, Hewitt S, Holbeck S, Chung YL, et al: Glut-1 as a therapeutic target: increased chemoresistance and HIF-1-independent link with cell turnover is revealed through COMPARE analysis and metabolomic studies. Cancer Chemother Pharmacol 61:377-393, 2008
    • (2008) Cancer Chemother Pharmacol , vol.61 , pp. 377-393
    • Evans, A.1    Bates, V.2    Troy, H.3    Hewitt, S.4    Holbeck, S.5    Chung, Y.L.6
  • 46
    • 45549093647 scopus 로고    scopus 로고
    • Survival of the fittest: cancer stem cells in therapeutic resistance and angiogenesis
    • Eyler CE, Rich JN: Survival of the fittest: cancer stem cells in therapeutic resistance and angiogenesis. J Clin Oncol 26:2839-2845, 2008
    • (2008) J Clin Oncol , vol.26 , pp. 2839-2845
    • Eyler, C.E.1    Rich, J.N.2
  • 47
    • 33947721693 scopus 로고    scopus 로고
    • Glioma cells suppress hypoxia-induced endothelial cell apoptosis and promote the angiogenic process
    • Ezhilarasan R, Mohanam I, Govindarajan K, Mohanam S: Glioma cells suppress hypoxia-induced endothelial cell apoptosis and promote the angiogenic process. Int J Oncol 30:701-707, 2007
    • (2007) Int J Oncol , vol.30 , pp. 701-707
    • Ezhilarasan, R.1    Mohanam, I.2    Govindarajan, K.3    Mohanam, S.4
  • 48
    • 14644432362 scopus 로고    scopus 로고
    • Apigenin inhibits VEGF and HIF-1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways
    • Fang J, Xia C, Cao Z, Zheng JZ, Reed E, Jiang BH: Apigenin inhibits VEGF and HIF-1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways. FASEB J 19:342-353, 2005
    • (2005) FASEB J , vol.19 , pp. 342-353
    • Fang, J.1    Xia, C.2    Cao, Z.3    Zheng, J.Z.4    Reed, E.5    Jiang, B.H.6
  • 49
    • 52049107208 scopus 로고    scopus 로고
    • Hypoxia-regulated protein expression, patient characteristics, and preoperative imaging as predictors of survival in adults with glioblastoma multiforme
    • Flynn JR, Wang L, Gillespie DL, Stoddard GJ, Reid JK, Owens J, et al: Hypoxia-regulated protein expression, patient characteristics, and preoperative imaging as predictors of survival in adults with glioblastoma multiforme. Cancer 113:1032-1042, 2008
    • (2008) Cancer , vol.113 , pp. 1032-1042
    • Flynn, J.R.1    Wang, L.2    Gillespie, D.L.3    Stoddard, G.J.4    Reid, J.K.5    Owens, J.6
  • 50
    • 70349747011 scopus 로고    scopus 로고
    • Glioma tumor stem-like cells promote tumor angiogenesis and vasculogenesis via vascular endothelial growth factor and stromal-derived factor 1
    • Folkins C, Shaked Y, Man S, Tang T, Lee CR, Zhu Z, et al: Glioma tumor stem-like cells promote tumor angiogenesis and vasculogenesis via vascular endothelial growth factor and stromal-derived factor 1. Cancer Res 69:7243-7251, 2009
    • (2009) Cancer Res , vol.69 , pp. 7243-7251
    • Folkins, C.1    Shaked, Y.2    Man, S.3    Tang, T.4    Lee, C.R.5    Zhu, Z.6
  • 51
    • 0029761644 scopus 로고    scopus 로고
    • Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
    • Forsythe JA, Jiang BH, Iyer NV, Agani F, Leung SW, Koos RD, et al: Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol 16:4604-4613, 1996
    • (1996) Mol Cell Biol , vol.16 , pp. 4604-4613
    • Forsythe, J.A.1    Jiang, B.H.2    Iyer, N.V.3    Agani, F.4    Leung, S.W.5    Koos, R.D.6
  • 53
    • 35848959917 scopus 로고    scopus 로고
    • Akt inhibitor shows anticancer and radiosensitizing effects in malignant glioma cells by inducing autophagy
    • Fujiwara K, Iwado E, Mills GB, Sawaya R, Kondo S, Kondo Y: Akt inhibitor shows anticancer and radiosensitizing effects in malignant glioma cells by inducing autophagy. Int J Oncol 31:753-760, 2007
    • (2007) Int J Oncol , vol.31 , pp. 753-760
    • Fujiwara, K.1    Iwado, E.2    Mills, G.B.3    Sawaya, R.4    Kondo, S.5    Kondo, Y.6
  • 54
    • 34247847903 scopus 로고    scopus 로고
    • Silencing hypoxia-inducible factor-1alpha inhibits cell migration and invasion under hypoxic environment in malignant gliomas
    • Fujiwara S, Nakagawa K, Harada H, Nagato S, Furukawa K, Teraoka M, et al: Silencing hypoxia-inducible factor-1alpha inhibits cell migration and invasion under hypoxic environment in malignant gliomas. Int J Oncol 30:793-802, 2007
    • (2007) Int J Oncol , vol.30 , pp. 793-802
    • Fujiwara, S.1    Nakagawa, K.2    Harada, H.3    Nagato, S.4    Furukawa, K.5    Teraoka, M.6
  • 55
    • 0031892776 scopus 로고    scopus 로고
    • Microsatellite deletion mapping on chromosome 10q and mutation analysis of MMAC1, FAS, and MXI1 in human glioblastoma multiforme
    • Fults D, Pedone CA, Thompson GE, Uchiyama CM, Gumpper KL, Iliev D, et al: Microsatellite deletion mapping on chromosome 10q and mutation analysis of MMAC1, FAS, and MXI1 in human glioblastoma multiforme. Int J Oncol 12:905-910, 1998
    • (1998) Int J Oncol , vol.12 , pp. 905-910
    • Fults, D.1    Pedone, C.A.2    Thompson, G.E.3    Uchiyama, C.M.4    Gumpper, K.L.5    Iliev, D.6
  • 57
    • 84876089266 scopus 로고    scopus 로고
    • Tissue biomarkers as prognostic variables of cervical cancer
    • Gadducci A, Guerrieri ME, Greco C: Tissue biomarkers as prognostic variables of cervical cancer. Crit Rev Oncol Hematol 86:104-129, 2013
    • (2013) Crit Rev Oncol Hematol , vol.86 , pp. 104-129
    • Gadducci, A.1    Guerrieri, M.E.2    Greco, C.3
  • 58
    • 77952219448 scopus 로고    scopus 로고
    • Mechanistic evaluation of the novel HSP90 inhibitor NVP-AUY922 in adult and pediatric glioblastoma
    • Gaspar N, Sharp SY, Eccles SA, Gowan S, Popov S, Jones C, et al: Mechanistic evaluation of the novel HSP90 inhibitor NVP-AUY922 in adult and pediatric glioblastoma. Mol Cancer Ther 9:1219-1233, 2010
    • (2010) Mol Cancer Ther , vol.9 , pp. 1219-1233
    • Gaspar, N.1    Sharp, S.Y.2    Eccles, S.A.3    Gowan, S.4    Popov, S.5    Jones, C.6
  • 60
    • 84916933180 scopus 로고    scopus 로고
    • RNA interference targeting HIF-1a via a novel multifunctional surfactant attenuates glioma growth in an intracranial mouse model
    • [in press]
    • Gillespie D, Arce-Larreta M, Ravichandran S, Leishman L, Berrondo C, Gamboa J, et al: RNA interference targeting HIF-1a via a novel multifunctional surfactant attenuates glioma growth in an intracranial mouse model. J Neurosurg [in press]
    • J Neurosurg
    • Gillespie, D.1    Arce-Larreta, M.2    Ravichandran, S.3    Leishman, L.4    Berrondo, C.5    Gamboa, J.6
  • 61
    • 34247847910 scopus 로고    scopus 로고
    • Silencing of hypoxia inducible factor-1alpha by RNA interference attenuates human glioma cell growth in vivo
    • Gillespie DL, Whang K, Ragel BT, Flynn JR, Kelly DA, Jensen RL: Silencing of hypoxia inducible factor-1alpha by RNA interference attenuates human glioma cell growth in vivo. Clin Cancer Res 13:2441-2448, 2007
    • (2007) Clin Cancer Res , vol.13 , pp. 2441-2448
    • Gillespie, D.L.1    Whang, K.2    Ragel, B.T.3    Flynn, J.R.4    Kelly, D.A.5    Jensen, R.L.6
  • 62
    • 0029785838 scopus 로고    scopus 로고
    • Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene
    • Gnarra JR, Zhou S, Merrill MJ, Wagner JR, Krumm A, Papavassiliou E, et al: Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene. Proc Natl Acad Sci U S A 93:10589-10594, 1996
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 10589-10594
    • Gnarra, J.R.1    Zhou, S.2    Merrill, M.J.3    Wagner, J.R.4    Krumm, A.5    Papavassiliou, E.6
  • 63
    • 0033521864 scopus 로고    scopus 로고
    • Hypoxia-mediated stimulation of carcinoma cell invasiveness via upregulation of urokinase receptor expression
    • Graham CH, Forsdike J, Fitzgerald CJ, Macdonald-Goodfellow S: Hypoxia-mediated stimulation of carcinoma cell invasiveness via upregulation of urokinase receptor expression. Int J Cancer 80:617-623, 1999
    • (1999) Int J Cancer , vol.80 , pp. 617-623
    • Graham, C.H.1    Forsdike, J.2    Fitzgerald, C.J.3    Macdonald-Goodfellow, S.4
  • 64
    • 84875911885 scopus 로고    scopus 로고
    • MiR-210 promotes a hypoxic phenotype and increases radioresistance in human lung cancer cell lines
    • Grosso S, Doyen J, Parks SK, Bertero T, Paye A, Cardinaud B, et al: MiR-210 promotes a hypoxic phenotype and increases radioresistance in human lung cancer cell lines. Cell Death Dis 4:e544, 2013
    • (2013) Cell Death Dis , vol.4
    • Grosso, S.1    Doyen, J.2    Parks, S.K.3    Bertero, T.4    Paye, A.5    Cardinaud, B.6
  • 66
    • 84906277818 scopus 로고    scopus 로고
    • Hypoxia suppresses cylindromatosis (CYLD) expression to promote inflammation in glioblastoma: possible link to acquired resistance to anti-VEGF therapy
    • Guo J, Shinriki S, Su Y, Nakamura T, Hayashi M, Tsuda Y, et al: Hypoxia suppresses cylindromatosis (CYLD) expression to promote inflammation in glioblastoma: possible link to acquired resistance to anti-VEGF therapy. Oncotarget 15:6353-6364, 2014
    • (2014) Oncotarget , vol.15 , pp. 6353-6364
    • Guo, J.1    Shinriki, S.2    Su, Y.3    Nakamura, T.4    Hayashi, M.5    Tsuda, Y.6
  • 67
    • 33646127170 scopus 로고    scopus 로고
    • The VHL/HIF oxygen-sensing pathway and its relevance to kidney disease
    • Haase VH: The VHL/HIF oxygen-sensing pathway and its relevance to kidney disease. Kidney Int 69:1302-1307, 2006
    • (2006) Kidney Int , vol.69 , pp. 1302-1307
    • Haase, V.H.1
  • 68
    • 24744467401 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1alpha and antiangiogenic activity of farnesyltransferase inhibitor SCH66336 in human aerodigestive tract cancer
    • Han JY, Oh SH, Morgillo F, Myers JN, Kim E, Hong WK, et al: Hypoxia-inducible factor 1alpha and antiangiogenic activity of farnesyltransferase inhibitor SCH66336 in human aerodigestive tract cancer. J Natl Cancer Inst 97:1272-1286, 2005
    • (2005) J Natl Cancer Inst , vol.97 , pp. 1272-1286
    • Han, J.Y.1    Oh, S.H.2    Morgillo, F.3    Myers, J.N.4    Kim, E.5    Hong, W.K.6
  • 69
    • 80053355093 scopus 로고    scopus 로고
    • How can we overcome tumor hypoxia in radiation therapy?
    • Harada H: How can we overcome tumor hypoxia in radiation therapy? J Radiat Res (Tokyo) 52:545-556, 2011
    • (2011) J Radiat Res (Tokyo) , vol.52 , pp. 545-556
    • Harada, H.1
  • 70
    • 84894265566 scopus 로고    scopus 로고
    • The effect of HIF-1a on glucose metabolism, growth and apoptosis of pancreatic cancerous cells
    • He G, Jiang Y, Zhang B, Wu G: The effect of HIF-1a on glucose metabolism, growth and apoptosis of pancreatic cancerous cells. Asia Pac J Clin Nutr 23:174-180, 2014
    • (2014) Asia Pac J Clin Nutr , vol.23 , pp. 174-180
    • He, G.1    Jiang, Y.2    Zhang, B.3    Wu, G.4
  • 71
    • 84890531155 scopus 로고    scopus 로고
    • Hypoxia-inducible factor pathway inhibition resolves tumor hypoxia and improves local tumor control after single-dose irradiation
    • Helbig L, Koi L, Brüchner K, Gurtner K, Hess-Stumpp H, Unterschemmann K, et al: Hypoxia-inducible factor pathway inhibition resolves tumor hypoxia and improves local tumor control after single-dose irradiation. Int J Radiat Oncol Biol Phys 88:159-166, 2014
    • (2014) Int J Radiat Oncol Biol Phys , vol.88 , pp. 159-166
    • Helbig, L.1    Koi, L.2    Brüchner, K.3    Gurtner, K.4    Hess-Stumpp, H.5    Unterschemmann, K.6
  • 72
    • 84884672514 scopus 로고    scopus 로고
    • Exposure to hypoxia following irradiation increases radioresistance in prostate cancer cells
    • Hennessey D, Martin LM, Atzberger A, Lynch TH, Hollywood D, Marignol L: Exposure to hypoxia following irradiation increases radioresistance in prostate cancer cells. Urol Oncol 31:1106-1116, 2013
    • (2013) Urol Oncol , vol.31 , pp. 1106-1116
    • Hennessey, D.1    Martin, L.M.2    Atzberger, A.3    Lynch, T.H.4    Hollywood, D.5    Marignol, L.6
  • 73
    • 75149165633 scopus 로고    scopus 로고
    • Prolyl hydroxylases 2 and 3 act in gliomas as protective negative feedback regulators of hypoxia-inducible factors
    • Henze AT, Riedel J, Diem T, Wenner J, Flamme I, Pouyseggur J, et al: Prolyl hydroxylases 2 and 3 act in gliomas as protective negative feedback regulators of hypoxia-inducible factors. Cancer Res 70:357-366, 2010
    • (2010) Cancer Res , vol.70 , pp. 357-366
    • Henze, A.T.1    Riedel, J.2    Diem, T.3    Wenner, J.4    Flamme, I.5    Pouyseggur, J.6
  • 74
    • 18544386401 scopus 로고    scopus 로고
    • Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family
    • Hewitson KS, McNeill LA, Riordan MV, Tian YM, Bullock AN, Welford RW, et al: Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family. J Biol Chem 277:26351-26355, 2002
    • (2002) J Biol Chem , vol.277 , pp. 26351-26355
    • Hewitson, K.S.1    McNeill, L.A.2    Riordan, M.V.3    Tian, Y.M.4    Bullock, A.N.5    Welford, R.W.6
  • 75
    • 84902338069 scopus 로고    scopus 로고
    • Identification of temozolomide resistance factors in glioblastoma via integrative miRNA/mRNA regulatory network analysis
    • Hiddingh L, Raktoe RS, Jeuken J, Hulleman E, Noske DP, Kaspers GJ, et al: Identification of temozolomide resistance factors in glioblastoma via integrative miRNA/mRNA regulatory network analysis. Sci Rep 4:5260, 2014
    • (2014) Sci Rep , vol.4 , pp. 5260
    • Hiddingh, L.1    Raktoe, R.S.2    Jeuken, J.3    Hulleman, E.4    Noske, D.P.5    Kaspers, G.J.6
  • 76
    • 0029775242 scopus 로고    scopus 로고
    • Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix
    • Hockel M, Schlenger K, Aral B, Mitze M, Schaffer U, Vaupel P: Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res 56:4509-4515, 1996
    • (1996) Cancer Res , vol.56 , pp. 4509-4515
    • Hockel, M.1    Schlenger, K.2    Aral, B.3    Mitze, M.4    Schaffer, U.5    Vaupel, P.6
  • 78
    • 84891496217 scopus 로고    scopus 로고
    • RACK1 promoted the growth and migration of the cancer cells in the progression of esophageal squamous cell carcinoma
    • Hu F, Tao Z, Wang M, Li G, Zhang Y, Zhong H, et al: RACK1 promoted the growth and migration of the cancer cells in the progression of esophageal squamous cell carcinoma. Tumour Biol 34:3893-3899, 2013
    • (2013) Tumour Biol , vol.34 , pp. 3893-3899
    • Hu, F.1    Tao, Z.2    Wang, M.3    Li, G.4    Zhang, Y.5    Zhong, H.6
  • 79
    • 84859385707 scopus 로고    scopus 로고
    • Hypoxia-induced autophagy promotes tumor cell survival and adaptation to antiangiogenic treatment in glioblastoma
    • Hu YL, DeLay M, Jahangiri A, Molinaro AM, Rose SD, Carbonell WS, et al: Hypoxia-induced autophagy promotes tumor cell survival and adaptation to antiangiogenic treatment in glioblastoma. Cancer Res 72:1773-1783, 2012
    • (2012) Cancer Res , vol.72 , pp. 1773-1783
    • Hu, Y.L.1    DeLay, M.2    Jahangiri, A.3    Molinaro, A.M.4    Rose, S.D.5    Carbonell, W.S.6
  • 81
    • 0031967883 scopus 로고    scopus 로고
    • Distinct patterns of deletion on 10p and 10q suggest involvement of multiple tumor suppressor genes in the development of astrocytic gliomas of different malignancy grades
    • Ichimura K, Schmidt EE, Miyakawa A, Goike HM, Collins VP: Distinct patterns of deletion on 10p and 10q suggest involvement of multiple tumor suppressor genes in the development of astrocytic gliomas of different malignancy grades. Genes Chromosomes Cancer 22:9-15, 1998
    • (1998) Genes Chromosomes Cancer , vol.22 , pp. 9-15
    • Ichimura, K.1    Schmidt, E.E.2    Miyakawa, A.3    Goike, H.M.4    Collins, V.P.5
  • 82
    • 33846562017 scopus 로고    scopus 로고
    • Extracellular acidosis elevates carbonic anhydrase IX in human glioblastoma cells via transcriptional modulation that does not depend on hypoxia
    • Ihnatko R, Kubes M, Takacova M, Sedlakova O, Sedlak J, Pastorek J, et al: Extracellular acidosis elevates carbonic anhydrase IX in human glioblastoma cells via transcriptional modulation that does not depend on hypoxia. Int J Oncol 29:1025-1033, 2006
    • (2006) Int J Oncol , vol.29 , pp. 1025-1033
    • Ihnatko, R.1    Kubes, M.2    Takacova, M.3    Sedlakova, O.4    Sedlak, J.5    Pastorek, J.6
  • 83
    • 84873735398 scopus 로고    scopus 로고
    • Arginase II expressed in cancer-associated fibroblasts indicates tissue hypoxia and predicts poor outcome in patients with pancreatic cancer
    • Ino Y, Yamazaki-Itoh R, Oguro S, Shimada K, Kosuge T, Zavada J, et al: Arginase II expressed in cancer-associated fibroblasts indicates tissue hypoxia and predicts poor outcome in patients with pancreatic cancer. PLoS ONE 8:e55146, 2013
    • (2013) PLoS ONE , vol.8
    • Ino, Y.1    Yamazaki-Itoh, R.2    Oguro, S.3    Shimada, K.4    Kosuge, T.5    Zavada, J.6
  • 84
    • 0037119415 scopus 로고    scopus 로고
    • Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway
    • Isaacs JS, Jung YJ, Mimnaugh EG, Martinez A, Cuttitta F, Neckers LM: Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway. J Biol Chem 277:29936-29944, 2002
    • (2002) J Biol Chem , vol.277 , pp. 29936-29944
    • Isaacs, J.S.1    Jung, Y.J.2    Mimnaugh, E.G.3    Martinez, A.4    Cuttitta, F.5    Neckers, L.M.6
  • 86
    • 84877098516 scopus 로고    scopus 로고
    • Gene expression profile identifies tyrosine kinase c-Met as a targetable mediator of antiangiogenic therapy resistance
    • Jahangiri A, De Lay M, Miller LM, Carbonell WS, Hu YL, Lu K, et al: Gene expression profile identifies tyrosine kinase c-Met as a targetable mediator of antiangiogenic therapy resistance. Clin Cancer Res 19:1773-1783, 2013
    • (2013) Clin Cancer Res , vol.19 , pp. 1773-1783
    • Jahangiri, A.1    De Lay, M.2    Miller, L.M.3    Carbonell, W.S.4    Hu, Y.L.5    Lu, K.6
  • 87
    • 33744828248 scopus 로고    scopus 로고
    • Glucose withdrawal induces oxidative stress followed by apoptosis in glioblastoma cells but not in normal human astrocytes
    • Jelluma N, Yang X, Stokoe D, Evan GI, Dansen TB, Haas-Kogan DA: Glucose withdrawal induces oxidative stress followed by apoptosis in glioblastoma cells but not in normal human astrocytes. Mol Cancer Res 4:319-330, 2006
    • (2006) Mol Cancer Res , vol.4 , pp. 319-330
    • Jelluma, N.1    Yang, X.2    Stokoe, D.3    Evan, G.I.4    Dansen, T.B.5    Haas-Kogan, D.A.6
  • 88
    • 65249131228 scopus 로고    scopus 로고
    • Brain tumor hypoxia: tumorigenesis, angiogenesis, imaging, pseudoprogression, and as a therapeutic target
    • Jensen RL: Brain tumor hypoxia: tumorigenesis, angiogenesis, imaging, pseudoprogression, and as a therapeutic target. J Neurooncol 92:317-335, 2009
    • (2009) J Neurooncol , vol.92 , pp. 317-335
    • Jensen, R.L.1
  • 89
    • 33747178432 scopus 로고    scopus 로고
    • Hypoxia in the tumorigenesis of gliomas and as a potential target for therapeutic measures
    • Jensen RL: Hypoxia in the tumorigenesis of gliomas and as a potential target for therapeutic measures. Neurosurg Focus 20(4):E24, 2006
    • (2006) Neurosurg Focus , vol.20 , Issue.4
    • Jensen, R.L.1
  • 90
    • 18744375998 scopus 로고    scopus 로고
    • Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation
    • Jeong JW, Bae MK, Ahn MY, Kim SH, Sohn TK, Bae MH, et al: Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation. Cell 111:709-720, 2002
    • (2002) Cell , vol.111 , pp. 709-720
    • Jeong, J.W.1    Bae, M.K.2    Ahn, M.Y.3    Kim, S.H.4    Sohn, T.K.5    Bae, M.H.6
  • 91
    • 84916883938 scopus 로고    scopus 로고
    • Pyruvate dehydrogenase kinase as a potential therapeutic target for malignant gliomas
    • Jha MK, Suk K: Pyruvate dehydrogenase kinase as a potential therapeutic target for malignant gliomas. Brain Tumor Res Treat 1:57-63, 2013
    • (2013) Brain Tumor Res Treat , vol.1 , pp. 57-63
    • Jha, M.K.1    Suk, K.2
  • 93
    • 0029944965 scopus 로고    scopus 로고
    • Dimerization, DNA binding, and transactivation properties of hypoxiainducible factor 1
    • Jiang BH, Rue E, Wang GL, Roe R, Semenza GL: Dimerization, DNA binding, and transactivation properties of hypoxiainducible factor 1. J Biol Chem 271:17771-17778, 1996
    • (1996) J Biol Chem , vol.271 , pp. 17771-17778
    • Jiang, B.H.1    Rue, E.2    Wang, G.L.3    Roe, R.4    Semenza, G.L.5
  • 94
    • 84555220669 scopus 로고    scopus 로고
    • In vivo specific delivery of c-Met siRNA to glioblastoma using cationic solid lipid nanoparticles
    • Jin J, Bae KH, Yang H, Lee SJ, Kim H, Kim Y, et al: In vivo specific delivery of c-Met siRNA to glioblastoma using cationic solid lipid nanoparticles. Bioconjug Chem 22:2568-2572, 2011
    • (2011) Bioconjug Chem , vol.22 , pp. 2568-2572
    • Jin, J.1    Bae, K.H.2    Yang, H.3    Lee, S.J.4    Kim, H.5    Kim, Y.6
  • 96
    • 84894579110 scopus 로고    scopus 로고
    • Inhibition of EGFR induces a c-MET-driven stem cell population in glioblastoma
    • Jun HJ, Bronson RT, Charest A: Inhibition of EGFR induces a c-MET-driven stem cell population in glioblastoma. Stem Cells 32:338-348, 2014
    • (2014) Stem Cells , vol.32 , pp. 338-348
    • Jun, H.J.1    Bronson, R.T.2    Charest, A.3
  • 97
    • 36749042647 scopus 로고    scopus 로고
    • AMG 102, a fully human anti-hepatocyte growth factor/scatter factor neutralizing antibody, enhances the efficacy of temozolomide or docetaxel in U-87 MG cells and xenografts
    • Jun HT, Sun J, Rex K, Radinsky R, Kendall R, Coxon A, et al: AMG 102, a fully human anti-hepatocyte growth factor/scatter factor neutralizing antibody, enhances the efficacy of temozolomide or docetaxel in U-87 MG cells and xenografts. Clin Cancer Res 13:6735-6742, 2007
    • (2007) Clin Cancer Res , vol.13 , pp. 6735-6742
    • Jun, H.T.1    Sun, J.2    Rex, K.3    Radinsky, R.4    Kendall, R.5    Coxon, A.6
  • 98
    • 0036718539 scopus 로고    scopus 로고
    • Molecular basis of the VHL hereditary cancer syndrome
    • Kaelin WG Jr: Molecular basis of the VHL hereditary cancer syndrome. Nat Rev Cancer 2:673-682, 2002
    • (2002) Nat Rev Cancer , vol.2 , pp. 673-682
    • Kaelin Jr, W.G.1
  • 99
    • 33746496671 scopus 로고    scopus 로고
    • Proteasomal inhibition attenuates transcriptional activity of hypoxia-inducible factor 1 (HIF-1) via specific effect on the HIF-1alpha C-terminal activation domain
    • Kaluz S, Kaluzová M, Stanbridge EJ: Proteasomal inhibition attenuates transcriptional activity of hypoxia-inducible factor 1 (HIF-1) via specific effect on the HIF-1alpha C-terminal activation domain. Mol Cell Biol 26:5895-5907, 2006
    • (2006) Mol Cell Biol , vol.26 , pp. 5895-5907
    • Kaluz, S.1    Kaluzová, M.2    Stanbridge, E.J.3
  • 100
    • 79951679423 scopus 로고    scopus 로고
    • At the crossroads of cancer and inflammation: Ras rewires an HIF-driven IL-1 autocrine loop
    • Kaluz S, Van Meir EG: At the crossroads of cancer and inflammation: Ras rewires an HIF-driven IL-1 autocrine loop. J Mol Med (Berl) 89:91-94, 2011
    • (2011) J Mol Med (Berl) , vol.89 , pp. 91-94
    • Kaluz, S.1    Van Meir, E.G.2
  • 101
    • 84873625209 scopus 로고    scopus 로고
    • The VHL tumor suppressor protein regulates tumorigenicity of U87-derived glioma stem-like cells by inhibiting the JAK/STAT signaling pathway
    • Kanno H, Sato H, Yokoyama TA, Yoshizumi T, Yamada S: The VHL tumor suppressor protein regulates tumorigenicity of U87-derived glioma stem-like cells by inhibiting the JAK/STAT signaling pathway. Int J Oncol 42:881-886, 2013
    • (2013) Int J Oncol , vol.42 , pp. 881-886
    • Kanno, H.1    Sato, H.2    Yokoyama, T.A.3    Yoshizumi, T.4    Yamada, S.5
  • 103
    • 84655161946 scopus 로고    scopus 로고
    • HIF1a and HIF2a: sibling rivalry in hypoxic tumour growth and progression
    • Keith B, Johnson RS, Simon MC: HIF1a and HIF2a: sibling rivalry in hypoxic tumour growth and progression. Nat Rev Cancer 12:9-22, 2012
    • (2012) Nat Rev Cancer , vol.12 , pp. 9-22
    • Keith, B.1    Johnson, R.S.2    Simon, M.C.3
  • 104
    • 78049404785 scopus 로고    scopus 로고
    • HIF-1a inhibition by siRNA or chetomin in human malignant glioma cells: effects on hypoxic radioresistance and monitoring via CA9 expression
    • Kessler J, Hahnel A, Wichmann H, Rot S, Kappler M, Bache M, et al: HIF-1a inhibition by siRNA or chetomin in human malignant glioma cells: effects on hypoxic radioresistance and monitoring via CA9 expression. BMC Cancer 10:605, 2010
    • (2010) BMC Cancer , vol.10 , pp. 605
    • Kessler, J.1    Hahnel, A.2    Wichmann, H.3    Rot, S.4    Kappler, M.5    Bache, M.6
  • 105
    • 79952740612 scopus 로고    scopus 로고
    • Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma
    • Keunen O, Johansson M, Oudin A, Sanzey M, Rahim SA, Fack F, et al: Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma. Proc Natl Acad Sci U S A 108:3749-3754, 2011
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 3749-3754
    • Keunen, O.1    Johansson, M.2    Oudin, A.3    Sanzey, M.4    Rahim, S.A.5    Fack, F.6
  • 106
    • 0036708853 scopus 로고    scopus 로고
    • Signaling cross-talk between hypoxia and glucose via hypoxia-inducible factor 1 and glucose response elements
    • Kietzmann T, Krones-Herzig A, Jungermann K: Signaling cross-talk between hypoxia and glucose via hypoxia-inducible factor 1 and glucose response elements. Biochem Pharmacol 64:903-911, 2002
    • (2002) Biochem Pharmacol , vol.64 , pp. 903-911
    • Kietzmann, T.1    Krones-Herzig, A.2    Jungermann, K.3
  • 107
    • 33644769210 scopus 로고    scopus 로고
    • Systemic anti-hepatocyte growth factor monoclonal antibody therapy induces the regression of intracranial glioma xenografts
    • Kim KJ, Wang L, Su YC, Gillespie GY, Salhotra A, Lal B, et al: Systemic anti-hepatocyte growth factor monoclonal antibody therapy induces the regression of intracranial glioma xenografts. Clin Cancer Res 12:1292-1298, 2006
    • (2006) Clin Cancer Res , vol.12 , pp. 1292-1298
    • Kim, K.J.1    Wang, L.2    Su, Y.C.3    Gillespie, G.Y.4    Salhotra, A.5    Lal, B.6
  • 108
    • 0033975850 scopus 로고    scopus 로고
    • Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: control of hypoxia-inducible factor-1 activity by nitric oxide
    • Kimura H, Weisz A, Kurashima Y, Hashimoto K, Ogura T, D'Acquisto F, et al: Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: control of hypoxia-inducible factor-1 activity by nitric oxide. Blood 95:189-197, 2000
    • (2000) Blood , vol.95 , pp. 189-197
    • Kimura, H.1    Weisz, A.2    Kurashima, Y.3    Hashimoto, K.4    Ogura, T.5    D'Acquisto, F.6
  • 109
    • 84865429409 scopus 로고    scopus 로고
    • Passing the baton: the HIF switch
    • Koh MY, Powis G: Passing the baton: the HIF switch. Trends Biochem Sci 37:364-372, 2012
    • (2012) Trends Biochem Sci , vol.37 , pp. 364-372
    • Koh, M.Y.1    Powis, G.2
  • 110
    • 84862776918 scopus 로고    scopus 로고
    • Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
    • Koivunen P, Lee S, Duncan CG, Lopez G, Lu G, Ramkissoon S, et al: Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation. Nature 483:484-488, 2012
    • (2012) Nature , vol.483 , pp. 484-488
    • Koivunen, P.1    Lee, S.2    Duncan, C.G.3    Lopez, G.4    Lu, G.5    Ramkissoon, S.6
  • 111
    • 0036528246 scopus 로고    scopus 로고
    • Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein
    • Kondo K, Klco J, Nakamura E, Lechpammer M, Kaelin WG Jr: Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein. Cancer Cell 1:237-246, 2002
    • (2002) Cancer Cell , vol.1 , pp. 237-246
    • Kondo, K.1    Klco, J.2    Nakamura, E.3    Lechpammer, M.4    Kaelin Jr, W.G.5
  • 112
    • 52149096024 scopus 로고    scopus 로고
    • PTEN signaling pathways in glioblastoma
    • Koul D: PTEN signaling pathways in glioblastoma. Cancer Biol Ther 7:1321-1325, 2008
    • (2008) Cancer Biol Ther , vol.7 , pp. 1321-1325
    • Koul, D.1
  • 113
    • 0034676331 scopus 로고    scopus 로고
    • Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function
    • Krieg M, Haas R, Brauch H, Acker T, Flamme I, Plate KH: Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function. Oncogene 19:5435-5443, 2000
    • (2000) Oncogene , vol.19 , pp. 5435-5443
    • Krieg, M.1    Haas, R.2    Brauch, H.3    Acker, T.4    Flamme, I.5    Plate, K.H.6
  • 114
    • 84878620894 scopus 로고    scopus 로고
    • Dichloroacetate reverses the hypoxic adaptation to bevacizumab and enhances its antitumor effects in mouse xenografts
    • Kumar K, Wigfield S, Gee HE, Devlin CM, Singleton D, Li JL, et al: Dichloroacetate reverses the hypoxic adaptation to bevacizumab and enhances its antitumor effects in mouse xenografts. J Mol Med (Berl) 91:749-758, 2013
    • (2013) J Mol Med (Berl) , vol.91 , pp. 749-758
    • Kumar, K.1    Wigfield, S.2    Gee, H.E.3    Devlin, C.M.4    Singleton, D.5    Li, J.L.6
  • 115
    • 84911946922 scopus 로고    scopus 로고
    • Neovascularization in glioblastoma: current pitfall in anti-angiogenic therapy
    • Kumar S, Arbab AS: Neovascularization in glioblastoma: current pitfall in anti-angiogenic therapy. Zhong Liu Za Zhi 1:16-19, 2013
    • (2013) Zhong Liu Za Zhi , vol.1 , pp. 16-19
    • Kumar, S.1    Arbab, A.S.2
  • 116
    • 84864412437 scopus 로고    scopus 로고
    • Inhibition of VEGF transcription through blockade of the hypoxia inducible factor-1a-p300 interaction by a small molecule
    • Kwon HS, Kim DR, Yang EG, Park YK, Ahn HC, Min SJ, et al: Inhibition of VEGF transcription through blockade of the hypoxia inducible factor-1a-p300 interaction by a small molecule. Bioorg Med Chem Lett 22:5249-5252, 2012
    • (2012) Bioorg Med Chem Lett , vol.22 , pp. 5249-5252
    • Kwon, H.S.1    Kim, D.R.2    Yang, E.G.3    Park, Y.K.4    Ahn, H.C.5    Min, S.J.6
  • 118
    • 20444467263 scopus 로고    scopus 로고
    • Targeting the c-Met pathway potentiates glioblastoma responses to gamma-radiation
    • Lal B, Xia S, Abounader R, Laterra J: Targeting the c-Met pathway potentiates glioblastoma responses to gamma-radiation. Clin Cancer Res 11:4479-4486, 2005
    • (2005) Clin Cancer Res , vol.11 , pp. 4479-4486
    • Lal, B.1    Xia, S.2    Abounader, R.3    Laterra, J.4
  • 119
    • 48949095975 scopus 로고    scopus 로고
    • Significant antitumor activity in vivo following treatment with the microtubule agent ENMD-1198
    • LaVallee TM, Burke PA, Swartz GM, Hamel E, Agoston GE, Shah J, et al: Significant antitumor activity in vivo following treatment with the microtubule agent ENMD-1198. Mol Cancer Ther 7:1472-1482, 2008
    • (2008) Mol Cancer Ther , vol.7 , pp. 1472-1482
    • LaVallee, T.M.1    Burke, P.A.2    Swartz, G.M.3    Hamel, E.4    Agoston, G.E.5    Shah, J.6
  • 120
    • 77449141050 scopus 로고    scopus 로고
    • MET molecular mechanisms and therapies in lung cancer
    • Lawrence RE, Salgia R: MET molecular mechanisms and therapies in lung cancer. Cell Adhes Migr 4:146-152, 2010
    • (2010) Cell Adhes Migr , vol.4 , pp. 146-152
    • Lawrence, R.E.1    Salgia, R.2
  • 121
    • 76649126249 scopus 로고    scopus 로고
    • Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression
    • Le A, Cooper CR, Gouw AM, Dinavahi R, Maitra A, Deck LM, et al: Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression. Proc Natl Acad Sci U S A 107:2037-2042, 2010
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 2037-2042
    • Le, A.1    Cooper, C.R.2    Gouw, A.M.3    Dinavahi, R.4    Maitra, A.5    Deck, L.M.6
  • 122
    • 82055185047 scopus 로고    scopus 로고
    • A novel approach to cancer therapy using PX-478 as a HIF-1a inhibitor
    • Lee K, Kim HM: A novel approach to cancer therapy using PX-478 as a HIF-1a inhibitor. Arch Pharm Res 34:1583-1585, 2011
    • (2011) Arch Pharm Res , vol.34 , pp. 1583-1585
    • Lee, K.1    Kim, H.M.2
  • 123
    • 0028266108 scopus 로고
    • Contemporary approaches to the treatment of malignant gliomas with radiation therapy
    • Leibel SA, Scott CB, Loeffler JS: Contemporary approaches to the treatment of malignant gliomas with radiation therapy. Semin Oncol 21:198-219, 1994
    • (1994) Semin Oncol , vol.21 , pp. 198-219
    • Leibel, S.A.1    Scott, C.B.2    Loeffler, J.S.3
  • 124
    • 84872839243 scopus 로고    scopus 로고
    • Rapamycin inhibits human glioma cell proliferation through down-regulating mammalian target of rapamycin pathway and up-regulating microRNA-143
    • Li C, Liu Y, Liu J, Chen Y, Li Z, Chen X, et al: Rapamycin inhibits human glioma cell proliferation through down-regulating mammalian target of rapamycin pathway and up-regulating microRNA-143. Head Neck Oncol 4:66, 2012
    • (2012) Head Neck Oncol , vol.4 , pp. 66
    • Li, C.1    Liu, Y.2    Liu, J.3    Chen, Y.4    Li, Z.5    Chen, X.6
  • 125
    • 84874440951 scopus 로고    scopus 로고
    • Expression and significance of hypoxia-inducible factor-1a and survivin in laryngeal carcinoma tissue and cells
    • Li DW, Zhou L, Jin B, Xie J, Dong P: Expression and significance of hypoxia-inducible factor-1a and survivin in laryngeal carcinoma tissue and cells. Otolaryngol Head Neck Surg 148:75-81, 2013
    • (2013) Otolaryngol Head Neck Surg , vol.148 , pp. 75-81
    • Li, D.W.1    Zhou, L.2    Jin, B.3    Xie, J.4    Dong, P.5
  • 126
    • 84863110128 scopus 로고    scopus 로고
    • Receptor for activated C kinase 1 (RACK1): a regulator for migration and invasion in oral squamous cell carcinoma cells
    • Li J, Guo Y, Feng X, Wang Z, Wang Y, Deng P, et al: Receptor for activated C kinase 1 (RACK1): a regulator for migration and invasion in oral squamous cell carcinoma cells. J Cancer Res Clin Oncol 138:563-571, 2012
    • (2012) J Cancer Res Clin Oncol , vol.138 , pp. 563-571
    • Li, J.1    Guo, Y.2    Feng, X.3    Wang, Z.4    Wang, Y.5    Deng, P.6
  • 127
    • 0030936323 scopus 로고    scopus 로고
    • PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
    • Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, et al: PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 275:1943-1947, 1997
    • (1997) Science , vol.275 , pp. 1943-1947
    • Li, J.1    Yen, C.2    Liaw, D.3    Podsypanina, K.4    Bose, S.5    Wang, S.I.6
  • 128
    • 79959971880 scopus 로고    scopus 로고
    • c-Met signaling induces a reprogramming network and supports the glioblastoma stem-like phenotype
    • Li Y, Li A, Glas M, Lal B, Ying M, Sang Y, et al: c-Met signaling induces a reprogramming network and supports the glioblastoma stem-like phenotype. Proc Natl Acad Sci U S A 108:9951-9956, 2011
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 9951-9956
    • Li, Y.1    Li, A.2    Glas, M.3    Lal, B.4    Ying, M.5    Sang, Y.6
  • 129
    • 65749106405 scopus 로고    scopus 로고
    • Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells
    • Li Z, Bao S, Wu Q, Wang H, Eyler C, Sathornsumetee S, et al: Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells. Cancer Cell 15:501-513, 2009
    • (2009) Cancer Cell , vol.15 , pp. 501-513
    • Li, Z.1    Bao, S.2    Wu, Q.3    Wang, H.4    Eyler, C.5    Sathornsumetee, S.6
  • 130
    • 77956415557 scopus 로고    scopus 로고
    • Clotrimazole induces a late G1 cell cycle arrest and sensitizes glioblastoma cells to radiation in vitro
    • Liu H, Li Y, Raisch KP: Clotrimazole induces a late G1 cell cycle arrest and sensitizes glioblastoma cells to radiation in vitro. Anticancer Drugs 21:841-849, 2010
    • (2010) Anticancer Drugs , vol.21 , pp. 841-849
    • Liu, H.1    Li, Y.2    Raisch, K.P.3
  • 131
    • 33846254999 scopus 로고    scopus 로고
    • RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha
    • Liu YV, Baek JH, Zhang H, Diez R, Cole RN, Semenza GL: RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha. Mol Cell 25:207-217, 2007
    • (2007) Mol Cell , vol.25 , pp. 207-217
    • Liu, Y.V.1    Baek, J.H.2    Zhang, H.3    Diez, R.4    Cole, R.N.5    Semenza, G.L.6
  • 132
    • 0037189542 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis
    • Lu H, Forbes RA, Verma A: Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis. J Biol Chem 277:23111-23115, 2002
    • (2002) J Biol Chem , vol.277 , pp. 23111-23115
    • Lu, H.1    Forbes, R.A.2    Verma, A.3
  • 133
    • 64349100198 scopus 로고    scopus 로고
    • Grape seed extract inhibits VEGF expression via reducing HIF-1alpha protein expression
    • Lu J, Zhang K, Chen S, Wen W: Grape seed extract inhibits VEGF expression via reducing HIF-1alpha protein expression. Carcinogenesis 30:636-644, 2009
    • (2009) Carcinogenesis , vol.30 , pp. 636-644
    • Lu, J.1    Zhang, K.2    Chen, S.3    Wen, W.4
  • 134
    • 84896739683 scopus 로고    scopus 로고
    • Mechanisms of evasive resistance to anti-VEGF therapy in glioblastoma
    • Lu KV, Bergers G: Mechanisms of evasive resistance to anti-VEGF therapy in glioblastoma. CNS Oncol 2:49-65, 2013
    • (2013) CNS Oncol , vol.2 , pp. 49-65
    • Lu, K.V.1    Bergers, G.2
  • 135
    • 84879005716 scopus 로고    scopus 로고
    • The role of Stat3 in glioblastoma multiforme
    • Luwor RB, Stylli SS, Kaye AH: The role of Stat3 in glioblastoma multiforme. J Clin Neurosci 20:907-911, 2013
    • (2013) J Clin Neurosci , vol.20 , pp. 907-911
    • Luwor, R.B.1    Stylli, S.S.2    Kaye, A.H.3
  • 137
    • 0036569704 scopus 로고    scopus 로고
    • Geldanamycin induces degradation of hypoxia-inducible factor 1alpha protein via the proteosome pathway in prostate cancer cells
    • Mabjeesh NJ, Post DE, Willard MT, Kaur B, Van Meir EG, Simons JW, et al: Geldanamycin induces degradation of hypoxia-inducible factor 1alpha protein via the proteosome pathway in prostate cancer cells. Cancer Res 62:2478-2482, 2002
    • (2002) Cancer Res , vol.62 , pp. 2478-2482
    • Mabjeesh, N.J.1    Post, D.E.2    Willard, M.T.3    Kaur, B.4    Van Meir, E.G.5    Simons, J.W.6
  • 138
    • 0038383678 scopus 로고    scopus 로고
    • Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth
    • Mack FA, Rathmell WK, Arsham AM, Gnarra J, Keith B, Simon MC: Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth. Cancer Cell 3:75-88, 2003
    • (2003) Cancer Cell , vol.3 , pp. 75-88
    • Mack, F.A.1    Rathmell, W.K.2    Arsham, A.M.3    Gnarra, J.4    Keith, B.5    Simon, M.C.6
  • 139
    • 84876701208 scopus 로고    scopus 로고
    • Poly (ethylene)-glycol conjugated solid lipid nanoparticles of noscapine improve biological half-life, brain delivery and efficacy in glioblastoma cells
    • Madan J, Pandey RS, Jain V, Katare OP, Chandra R, Katyal A: Poly (ethylene)-glycol conjugated solid lipid nanoparticles of noscapine improve biological half-life, brain delivery and efficacy in glioblastoma cells. Nanomedicine (Lond Print) 9:492-503, 2013
    • (2013) Nanomedicine (Lond Print) , vol.9 , pp. 492-503
    • Madan, J.1    Pandey, R.S.2    Jain, V.3    Katare, O.P.4    Chandra, R.5    Katyal, A.6
  • 140
    • 0035887011 scopus 로고    scopus 로고
    • FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity
    • Mahon PC, Hirota K, Semenza GL: FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev 15:2675-2686, 2001
    • (2001) Genes Dev , vol.15 , pp. 2675-2686
    • Mahon, P.C.1    Hirota, K.2    Semenza, G.L.3
  • 141
    • 2942724235 scopus 로고    scopus 로고
    • mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways
    • Majumder PK, Febbo PG, Bikoff R, Berger R, Xue Q, McMahon LM, et al: mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways. Nat Med 10:594-601, 2004
    • (2004) Nat Med , vol.10 , pp. 594-601
    • Majumder, P.K.1    Febbo, P.G.2    Bikoff, R.3    Berger, R.4    Xue, Q.5    McMahon, L.M.6
  • 142
    • 0031022499 scopus 로고    scopus 로고
    • Effect of glucose transport inhibitors on vincristine efflux in multidrug-resistant murine erythroleukaemia cells overexpressing the multidrug resistanceassociated protein (MRP) and two glucose transport proteins, GLUT1 and GLUT3
    • Martell RL, Slapak CA, Levy SB: Effect of glucose transport inhibitors on vincristine efflux in multidrug-resistant murine erythroleukaemia cells overexpressing the multidrug resistanceassociated protein (MRP) and two glucose transport proteins, GLUT1 and GLUT3. Br J Cancer 75:161-168, 1997
    • (1997) Br J Cancer , vol.75 , pp. 161-168
    • Martell, R.L.1    Slapak, C.A.2    Levy, S.B.3
  • 144
    • 84897974538 scopus 로고    scopus 로고
    • mTORC2 dictates Warburg effect and drug resistance
    • Masui K, Cavenee WK, Mischel PS: mTORC2 dictates Warburg effect and drug resistance. Cell Cycle 13:1053-1054, 2014
    • (2014) Cell Cycle , vol.13 , pp. 1053-1054
    • Masui, K.1    Cavenee, W.K.2    Mischel, P.S.3
  • 145
    • 84887430714 scopus 로고    scopus 로고
    • mTOR complex 2 controls glycolytic metabolism in glioblastoma through FoxO acetylation and upregulation of c-Myc
    • Masui K, Tanaka K, Akhavan D, Babic I, Gini B, Matsutani T, et al: mTOR complex 2 controls glycolytic metabolism in glioblastoma through FoxO acetylation and upregulation of c-Myc. Cell Metab 18:726-739, 2013
    • (2013) Cell Metab , vol.18 , pp. 726-739
    • Masui, K.1    Tanaka, K.2    Akhavan, D.3    Babic, I.4    Gini, B.5    Matsutani, T.6
  • 146
    • 0033587146 scopus 로고    scopus 로고
    • The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
    • Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC, Cockman ME, et al: The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399:271-275, 1999
    • (1999) Nature , vol.399 , pp. 271-275
    • Maxwell, P.H.1    Wiesener, M.S.2    Chang, G.W.3    Clifford, S.C.4    Vaux, E.C.5    Cockman, M.E.6
  • 147
    • 84877087466 scopus 로고    scopus 로고
    • Glioblastoma resistance to anti-VEGF therapy: has the challenge been MET?
    • McCarty JH: Glioblastoma resistance to anti-VEGF therapy: has the challenge been MET? Clin Cancer Res 19:1631-1633, 2013
    • (2013) Clin Cancer Res , vol.19 , pp. 1631-1633
    • McCarty, J.H.1
  • 148
    • 84861762712 scopus 로고    scopus 로고
    • Carbonic anhydrase IX promotes tumor growth and necrosis in vivo and inhibition enhances anti-VEGF therapy
    • McIntyre A, Patiar S, Wigfield S, Li JL, Ledaki I, Turley H, et al: Carbonic anhydrase IX promotes tumor growth and necrosis in vivo and inhibition enhances anti-VEGF therapy. Clin Cancer Res 18:3100-3111, 2012
    • (2012) Clin Cancer Res , vol.18 , pp. 3100-3111
    • McIntyre, A.1    Patiar, S.2    Wigfield, S.3    Li, J.L.4    Ledaki, I.5    Turley, H.6
  • 149
    • 84867514301 scopus 로고    scopus 로고
    • Targeting hypoxia, HIF-1, and tumor glucose metabolism to improve radiotherapy efficacy
    • Meijer TW, Kaanders JH, Span PN, Bussink J: Targeting hypoxia, HIF-1, and tumor glucose metabolism to improve radiotherapy efficacy. Clin Cancer Res 18:5585-5594, 2012
    • (2012) Clin Cancer Res , vol.18 , pp. 5585-5594
    • Meijer, T.W.1    Kaanders, J.H.2    Span, P.N.3    Bussink, J.4
  • 150
    • 34347206794 scopus 로고    scopus 로고
    • Hypoxia inhibits paclitaxel-induced apoptosis through adenosine-mediated phosphorylation of bad in glioblastoma cells
    • Merighi S, Benini A, Mirandola P, Gessi S, Varani K, Leung E, et al: Hypoxia inhibits paclitaxel-induced apoptosis through adenosine-mediated phosphorylation of bad in glioblastoma cells. Mol Pharmacol 72:162-172, 2007
    • (2007) Mol Pharmacol , vol.72 , pp. 162-172
    • Merighi, S.1    Benini, A.2    Mirandola, P.3    Gessi, S.4    Varani, K.5    Leung, E.6
  • 151
    • 84869748840 scopus 로고    scopus 로고
    • Biochemical and pharmacological characterization of human c-Met neutralizing monoclonal antibody CE-355621
    • Michaud NR, Jani JP, Hillerman S, Tsaparikos KE, Barbacci-Tobin EG, Knauth E, et al: Biochemical and pharmacological characterization of human c-Met neutralizing monoclonal antibody CE-355621. MAbs 4:710-723, 2012
    • (2012) MAbs , vol.4 , pp. 710-723
    • Michaud, N.R.1    Jani, J.P.2    Hillerman, S.3    Tsaparikos, K.E.4    Barbacci-Tobin, E.G.5    Knauth, E.6
  • 153
    • 0037225763 scopus 로고    scopus 로고
    • Inhibition of hypoxia-induced angiogenesis by FK228, a specific histone deacetylase inhibitor, via suppression of HIF-1alpha activity
    • Mie Lee Y, Kim SH, Kim HS, Jin Son M, Nakajima H, Jeong Kwon H, et al: Inhibition of hypoxia-induced angiogenesis by FK228, a specific histone deacetylase inhibitor, via suppression of HIF-1alpha activity. Biochem Biophys Res Commun 300:241-246, 2003
    • (2003) Biochem Biophys Res Commun , vol.300 , pp. 241-246
    • Mie Lee, Y.1    Kim, S.H.2    Kim, H.S.3    Jin Son, M.4    Nakajima, H.5    Jeong Kwon, H.6
  • 154
    • 84866437189 scopus 로고    scopus 로고
    • 17AEP-GA, an HSP90 antagonist, is a potent inhibitor of glioblastoma cell proliferation, survival, migration and invasion
    • Miekus K, Kijowski J, Sekula M, Majka M: 17AEP-GA, an HSP90 antagonist, is a potent inhibitor of glioblastoma cell proliferation, survival, migration and invasion. Oncol Rep 28:1903-1909, 2012
    • (2012) Oncol Rep , vol.28 , pp. 1903-1909
    • Miekus, K.1    Kijowski, J.2    Sekula, M.3    Majka, M.4
  • 155
    • 84874377917 scopus 로고    scopus 로고
    • Increased radiosensitivity and radiothermosensitivity of human pancreatic MIA PaCa-2 and U251 glioblastoma cell lines treated with the novel Hsp90 inhibitor NVP-HSP990
    • Milanovic D, Firat E, Grosu AL, Niedermann G: Increased radiosensitivity and radiothermosensitivity of human pancreatic MIA PaCa-2 and U251 glioblastoma cell lines treated with the novel Hsp90 inhibitor NVP-HSP990. Radiat Oncol 8:42, 2013
    • (2013) Radiat Oncol , vol.8 , pp. 42
    • Milanovic, D.1    Firat, E.2    Grosu, A.L.3    Niedermann, G.4
  • 156
    • 31544443522 scopus 로고    scopus 로고
    • The evolution of chemoradiation for glioblastoma: a modern success story
    • Mirimanoff RO: The evolution of chemoradiation for glioblastoma: a modern success story. Curr Oncol Rep 8:50-53, 2006
    • (2006) Curr Oncol Rep , vol.8 , pp. 50-53
    • Mirimanoff, R.O.1
  • 157
    • 84866950193 scopus 로고    scopus 로고
    • Comparison of spheroids formed by rat glioma stem cells and neural stem cells reveals differences in glucose metabolism and promising therapeutic applications
    • Morfouace M, Lalier L, Bahut M, Bonnamain V, Naveilhan P, Guette C, et al: Comparison of spheroids formed by rat glioma stem cells and neural stem cells reveals differences in glucose metabolism and promising therapeutic applications. J Biol Chem 287:33664-33674, 2012
    • (2012) J Biol Chem , vol.287 , pp. 33664-33674
    • Morfouace, M.1    Lalier, L.2    Bahut, M.3    Bonnamain, V.4    Naveilhan, P.5    Guette, C.6
  • 158
    • 84878211420 scopus 로고    scopus 로고
    • Menadione and ethacrynic acid inhibit the hypoxia-inducible factor (HIF) pathway by disrupting HIF-1a interaction with p300
    • Na YR, Han KC, Park H, Yang EG: Menadione and ethacrynic acid inhibit the hypoxia-inducible factor (HIF) pathway by disrupting HIF-1a interaction with p300. Biochem Biophys Res Commun 434:879-884, 2013
    • (2013) Biochem Biophys Res Commun , vol.434 , pp. 879-884
    • Na, Y.R.1    Han, K.C.2    Park, H.3    Yang, E.G.4
  • 159
    • 20244374417 scopus 로고    scopus 로고
    • Human bone marrow-derived mesenchymal stem cells in the treatment of gliomas
    • Nakamizo A, Marini F, Amano T, Khan A, Studeny M, Gumin J, et al: Human bone marrow-derived mesenchymal stem cells in the treatment of gliomas. Cancer Res 65:3307-3318, 2005
    • (2005) Cancer Res , vol.65 , pp. 3307-3318
    • Nakamizo, A.1    Marini, F.2    Amano, T.3    Khan, A.4    Studeny, M.5    Gumin, J.6
  • 160
    • 78650797956 scopus 로고    scopus 로고
    • Zinc downregulates HIF-1a and inhibits its activity in tumor cells in vitro and in vivo
    • Nardinocchi L, Pantisano V, Puca R, Porru M, Aiello A, Grasselli A, et al: Zinc downregulates HIF-1a and inhibits its activity in tumor cells in vitro and in vivo. PLoS ONE 5:e15048, 2010
    • (2010) PLoS ONE , vol.5
    • Nardinocchi, L.1    Pantisano, V.2    Puca, R.3    Porru, M.4    Aiello, A.5    Grasselli, A.6
  • 162
    • 84874593624 scopus 로고    scopus 로고
    • Effects of dual targeting of tumor cells and stroma in human glioblastoma xenografts with a tyrosine kinase inhibitor against c-MET and VEGFR2
    • Navis AC, Bourgonje A, Wesseling P, Wright A, Hendriks W, Verrijp K, et al: Effects of dual targeting of tumor cells and stroma in human glioblastoma xenografts with a tyrosine kinase inhibitor against c-MET and VEGFR2. PLoS ONE 8:e58262, 2013
    • (2013) PLoS ONE , vol.8
    • Navis, A.C.1    Bourgonje, A.2    Wesseling, P.3    Wright, A.4    Hendriks, W.5    Verrijp, K.6
  • 163
    • 53749106421 scopus 로고    scopus 로고
    • Noscapine induces apoptosis in human glioma cells by an apoptosis-inducing factor-dependent pathway
    • Newcomb EW, Lukyanov Y, Smirnova I, Schnee T, Zagzag D: Noscapine induces apoptosis in human glioma cells by an apoptosis-inducing factor-dependent pathway. Anticancer Drugs 19:553-563, 2008
    • (2008) Anticancer Drugs , vol.19 , pp. 553-563
    • Newcomb, E.W.1    Lukyanov, Y.2    Smirnova, I.3    Schnee, T.4    Zagzag, D.5
  • 165
    • 70349653793 scopus 로고    scopus 로고
    • IDH1 mutations as molecular signature and predictive factor of secondary glioblastomas
    • Nobusawa S, Watanabe T, Kleihues P, Ohgaki H: IDH1 mutations as molecular signature and predictive factor of secondary glioblastomas. Clin Cancer Res 15:6002-6007, 2009
    • (2009) Clin Cancer Res , vol.15 , pp. 6002-6007
    • Nobusawa, S.1    Watanabe, T.2    Kleihues, P.3    Ohgaki, H.4
  • 166
    • 84874091180 scopus 로고    scopus 로고
    • The definition of primary and secondary glioblastoma
    • Ohgaki H, Kleihues P: The definition of primary and secondary glioblastoma. Clin Cancer Res 19:764-772, 2013
    • (2013) Clin Cancer Res , vol.19 , pp. 764-772
    • Ohgaki, H.1    Kleihues, P.2
  • 167
    • 0033776536 scopus 로고    scopus 로고
    • Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein
    • Ohh M, Park CW, Ivan M, Hoffman MA, Kim TY, Huang LE, et al: Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein. Nat Cell Biol 2:423-427, 2000
    • (2000) Nat Cell Biol , vol.2 , pp. 423-427
    • Ohh, M.1    Park, C.W.2    Ivan, M.3    Hoffman, M.A.4    Kim, T.Y.5    Huang, L.E.6
  • 168
    • 84893719338 scopus 로고    scopus 로고
    • The immunohistochemical expression of c-Met is an independent predictor of survival in patients with glioblastoma multiforme
    • Olmez OF, Cubukcu E, Evrensel T, Kurt M, Avci N, Tolunay S, et al: The immunohistochemical expression of c-Met is an independent predictor of survival in patients with glioblastoma multiforme. Clin Transl Oncol 16:173-177, 2014
    • (2014) Clin Transl Oncol , vol.16 , pp. 173-177
    • Olmez, O.F.1    Cubukcu, E.2    Evrensel, T.3    Kurt, M.4    Avci, N.5    Tolunay, S.6
  • 169
    • 72849115544 scopus 로고    scopus 로고
    • Development of HIF-1 inhibitors for cancer therapy
    • Onnis B, Rapisarda A, Melillo G: Development of HIF-1 inhibitors for cancer therapy. J Cell Mol Med 13 (9A):2780-2786, 2009
    • (2009) J Cell Mol Med , vol.13 , Issue.9 A , pp. 2780-2786
    • Onnis, B.1    Rapisarda, A.2    Melillo, G.3
  • 170
    • 4544325479 scopus 로고    scopus 로고
    • Apigenin suppresses the expression of VEGF, an important factor for angiogenesis, in endothelial cells via degradation of HIF-1alpha protein
    • Osada M, Imaoka S, Funae Y: Apigenin suppresses the expression of VEGF, an important factor for angiogenesis, in endothelial cells via degradation of HIF-1alpha protein. FEBS Lett 575:59-63, 2004
    • (2004) FEBS Lett , vol.575 , pp. 59-63
    • Osada, M.1    Imaoka, S.2    Funae, Y.3
  • 171
    • 84885051395 scopus 로고    scopus 로고
    • Forced downregulation of RACK1 inhibits glioma development by suppressing Src/Akt signaling activity
    • Peng R, Jiang B, Ma J, Ma Z, Wan X, Liu H, et al: Forced downregulation of RACK1 inhibits glioma development by suppressing Src/Akt signaling activity. Oncol Rep 30:2195-2202, 2013
    • (2013) Oncol Rep , vol.30 , pp. 2195-2202
    • Peng, R.1    Jiang, B.2    Ma, J.3    Ma, Z.4    Wan, X.5    Liu, H.6
  • 172
    • 34250724520 scopus 로고    scopus 로고
    • The SDF-1-CXCR4 signaling pathway: a molecular hub modulating neo-angiogenesis
    • Petit I, Jin D, Rafii S: The SDF-1-CXCR4 signaling pathway: a molecular hub modulating neo-angiogenesis. Trends Immunol 28:299-307, 2007
    • (2007) Trends Immunol , vol.28 , pp. 299-307
    • Petit, I.1    Jin, D.2    Rafii, S.3
  • 173
    • 84883009929 scopus 로고    scopus 로고
    • Acquired resistance to anti-VEGF therapy in glioblastoma is associated with a mesenchymal transition
    • Piao Y, Liang J, Holmes L, Henry V, Sulman E, de Groot JF: Acquired resistance to anti-VEGF therapy in glioblastoma is associated with a mesenchymal transition. Clin Cancer Res 19:4392-4403, 2013
    • (2013) Clin Cancer Res , vol.19 , pp. 4392-4403
    • Piao, Y.1    Liang, J.2    Holmes, L.3    Henry, V.4    Sulman, E.5    de Groot, J.F.6
  • 174
    • 84893342957 scopus 로고    scopus 로고
    • Isocitrate dehydrogenase-1 mutations as prognostic biomarker in glioblastoma multiforme patients in West Bohemia
    • Polivka J, Polivka J Jr, Rohan V, Pesta M, Repik T, Pitule P, et al: Isocitrate dehydrogenase-1 mutations as prognostic biomarker in glioblastoma multiforme patients in West Bohemia. Biomed Res Int 2014:735659, 2014
    • (2014) Biomed Res Int , vol.2014 , pp. 735659
    • Polivka, J.1    Polivka Jr, J.2    Rohan, V.3    Pesta, M.4    Repik, T.5    Pitule, P.6
  • 175
    • 26444570010 scopus 로고    scopus 로고
    • Accumulation of Krebs cycle intermediates and overexpression of HIF1alpha in tumours which result from germline FH and SDH mutations
    • Pollard PJ, Brière JJ, Alam NA, Barwell J, Barclay E, Wortham NC, et al: Accumulation of Krebs cycle intermediates and overexpression of HIF1alpha in tumours which result from germline FH and SDH mutations. Hum Mol Genet 14:2231-2239, 2005
    • (2005) Hum Mol Genet , vol.14 , pp. 2231-2239
    • Pollard, P.J.1    Brière, J.J.2    Alam, N.A.3    Barwell, J.4    Barclay, E.5    Wortham, N.C.6
  • 176
    • 33750728003 scopus 로고    scopus 로고
    • HIV protease inhibitors decrease VEGF/HIF-1alpha expression and angiogenesis in glioblastoma cells
    • Pore N, Gupta AK, Cerniglia GJ, Maity A: HIV protease inhibitors decrease VEGF/HIF-1alpha expression and angiogenesis in glioblastoma cells. Neoplasia 8:889-895, 2006
    • (2006) Neoplasia , vol.8 , pp. 889-895
    • Pore, N.1    Gupta, A.K.2    Cerniglia, G.J.3    Maity, A.4
  • 177
    • 74249111545 scopus 로고    scopus 로고
    • Ansamycin inhibitors of Hsp90: nature's prototype for anti-chaperone therapy
    • Porter JR, Ge J, Lee J, Normant E, West K: Ansamycin inhibitors of Hsp90: nature's prototype for anti-chaperone therapy. Curr Top Med Chem 9:1386-1418, 2009
    • (2009) Curr Top Med Chem , vol.9 , pp. 1386-1418
    • Porter, J.R.1    Ge, J.2    Lee, J.3    Normant, E.4    West, K.5
  • 179
    • 0042847064 scopus 로고    scopus 로고
    • Diagnostic, prognostic and therapeutic implications of carbonic anhydrases in cancer
    • Potter CP, Harris AL: Diagnostic, prognostic and therapeutic implications of carbonic anhydrases in cancer. Br J Cancer 89:2-7, 2003
    • (2003) Br J Cancer , vol.89 , pp. 2-7
    • Potter, C.P.1    Harris, A.L.2
  • 181
    • 84881441534 scopus 로고    scopus 로고
    • Synergistic suppression of noscapine and conventional chemotherapeutics on human glioblastoma cell growth
    • Qi Q, Liu X, Li S, Joshi HC, Ye K: Synergistic suppression of noscapine and conventional chemotherapeutics on human glioblastoma cell growth. Acta Pharmacol Sin 34:930-938, 2013
    • (2013) Acta Pharmacol Sin , vol.34 , pp. 930-938
    • Qi, Q.1    Liu, X.2    Li, S.3    Joshi, H.C.4    Ye, K.5
  • 182
    • 1242271198 scopus 로고    scopus 로고
    • Topoisomerase I-mediated inhibition of hypoxiainducible factor 1: mechanism and therapeutic implications
    • Rapisarda A, Uranchimeg B, Sordet O, Pommier Y, Shoemaker RH, Melillo G: Topoisomerase I-mediated inhibition of hypoxiainducible factor 1: mechanism and therapeutic implications. Cancer Res 64:1475-1482, 2004
    • (2004) Cancer Res , vol.64 , pp. 1475-1482
    • Rapisarda, A.1    Uranchimeg, B.2    Sordet, O.3    Pommier, Y.4    Shoemaker, R.H.5    Melillo, G.6
  • 183
    • 4944229705 scopus 로고    scopus 로고
    • Schedule-dependent inhibition of hypoxia-inducible factor-1alpha protein accumulation, angiogenesis, and tumor growth by topotecan in U251-HRE glioblastoma xenografts
    • Rapisarda A, Zalek J, Hollingshead M, Braunschweig T, Uranchimeg B, Bonomi CA, et al: Schedule-dependent inhibition of hypoxia-inducible factor-1alpha protein accumulation, angiogenesis, and tumor growth by topotecan in U251-HRE glioblastoma xenografts. Cancer Res 64:6845-6848, 2004
    • (2004) Cancer Res , vol.64 , pp. 6845-6848
    • Rapisarda, A.1    Zalek, J.2    Hollingshead, M.3    Braunschweig, T.4    Uranchimeg, B.5    Bonomi, C.A.6
  • 184
    • 35148870732 scopus 로고    scopus 로고
    • Glut-1 antibodies induce growth arrest and apoptosis in human cancer cell lines
    • Rastogi S, Banerjee S, Chellappan S, Simon GR: Glut-1 antibodies induce growth arrest and apoptosis in human cancer cell lines. Cancer Lett 257:244-251, 2007
    • (2007) Cancer Lett , vol.257 , pp. 244-251
    • Rastogi, S.1    Banerjee, S.2    Chellappan, S.3    Simon, G.R.4
  • 185
    • 84875800035 scopus 로고    scopus 로고
    • In vivo c-Met pathway inhibition depletes human glioma xenografts of tumorpropagating stem-like cells
    • Rath P, Lal B, Ajala O, Li Y, Xia S, Kim J, et al: In vivo c-Met pathway inhibition depletes human glioma xenografts of tumorpropagating stem-like cells. Transl Oncol 6:104-111, 2013
    • (2013) Transl Oncol , vol.6 , pp. 104-111
    • Rath, P.1    Lal, B.2    Ajala, O.3    Li, Y.4    Xia, S.5    Kim, J.6
  • 186
    • 1642453727 scopus 로고    scopus 로고
    • Identification of necrosis-associated genes in glioblastoma by cDNA microarray analysis
    • Raza SM, Fuller GN, Rhee CH, Huang S, Hess K, Zhang W, et al: Identification of necrosis-associated genes in glioblastoma by cDNA microarray analysis. Clin Cancer Res 10:212-221, 2004
    • (2004) Clin Cancer Res , vol.10 , pp. 212-221
    • Raza, S.M.1    Fuller, G.N.2    Rhee, C.H.3    Huang, S.4    Hess, K.5    Zhang, W.6
  • 187
    • 84900029890 scopus 로고    scopus 로고
    • Epidithiodiketopiperazines (ETPs) exhibit in vitro antiangiogenic and in vivo antitumor activity by disrupting the HIF-1a/p300 complex in a preclinical model of prostate cancer
    • Reece KM, Richardson ED, Cook KM, Campbell TJ, Pisle ST, Holly AJ, et al: Epidithiodiketopiperazines (ETPs) exhibit in vitro antiangiogenic and in vivo antitumor activity by disrupting the HIF-1a/p300 complex in a preclinical model of prostate cancer. Mol Cancer 13:91, 2014
    • (2014) Mol Cancer , vol.13 , pp. 91
    • Reece, K.M.1    Richardson, E.D.2    Cook, K.M.3    Campbell, T.J.4    Pisle, S.T.5    Holly, A.J.6
  • 189
    • 0004580887 scopus 로고
    • Transient hypoxia enhances the frequency of dihydrofolate reductase gene amplification in Chinese hamster ovary cells
    • Rice GC, Hoy C, Schimke RT: Transient hypoxia enhances the frequency of dihydrofolate reductase gene amplification in Chinese hamster ovary cells. Proc Natl Acad Sci U S A 83:5978-5982, 1986
    • (1986) Proc Natl Acad Sci U S A , vol.83 , pp. 5978-5982
    • Rice, G.C.1    Hoy, C.2    Schimke, R.T.3
  • 191
  • 192
    • 33746696738 scopus 로고    scopus 로고
    • 'Pseudopalisading' necrosis in glioblastoma: a familiar morphologic feature that links vascular pathology, hypoxia, and angiogenesis
    • Rong Y, Durden DL, Van Meir EG, Brat DJ: 'Pseudopalisading' necrosis in glioblastoma: a familiar morphologic feature that links vascular pathology, hypoxia, and angiogenesis. J Neuropathol Exp Neurol 65:529-539, 2006
    • (2006) JNeuropathol Exp Neurol , vol.65 , pp. 529-539
    • Rong, Y.1    Durden, D.L.2    Van Meir, E.G.3    Brat, D.J.4
  • 194
    • 84878569070 scopus 로고    scopus 로고
    • Hypoxia induced CA9 inhibitory targeting by two different sulfonamide derivatives including acetazolamide in human glioblastoma
    • Said HM, Hagemann C, Carta F, Katzer A, Polat B, Staab A, et al: Hypoxia induced CA9 inhibitory targeting by two different sulfonamide derivatives including acetazolamide in human glioblastoma. Bioorg Med Chem 21:3949-3957, 2013
    • (2013) Bioorg Med Chem , vol.21 , pp. 3949-3957
    • Said, H.M.1    Hagemann, C.2    Carta, F.3    Katzer, A.4    Polat, B.5    Staab, A.6
  • 195
    • 84881479778 scopus 로고    scopus 로고
    • Targeting the PI3K/AKT/mTOR signaling pathway in glioblastoma: novel therapeutic agents and advances in understanding
    • Sami A, Karsy M: Targeting the PI3K/AKT/mTOR signaling pathway in glioblastoma: novel therapeutic agents and advances in understanding. Tumour Biol 34:1991-2002, 2013
    • (2013) Tumour Biol , vol.34 , pp. 1991-2002
    • Sami, A.1    Karsy, M.2
  • 196
    • 0028061116 scopus 로고
    • Hypoxia-induced resistance to doxorubicin and methotrexate in human melanoma cell lines in vitro
    • Sanna K, Rofstad EK: Hypoxia-induced resistance to doxorubicin and methotrexate in human melanoma cell lines in vitro. Int J Cancer 58:258-262, 1994
    • (1994) Int J Cancer , vol.58 , pp. 258-262
    • Sanna, K.1    Rofstad, E.K.2
  • 198
    • 38349155463 scopus 로고    scopus 로고
    • Tumor angiogenic and hypoxic profiles predict radiographic response and survival in malignant astrocytoma patients treated with bevacizumab and irinotecan
    • Sathornsumetee S, Cao Y, Marcello JE, Herndon JE II, McLendon RE, Desjardins A, et al: Tumor angiogenic and hypoxic profiles predict radiographic response and survival in malignant astrocytoma patients treated with bevacizumab and irinotecan. J Clin Oncol 26:271-278, 2008
    • (2008) J Clin Oncol , vol.26 , pp. 271-278
    • Sathornsumetee, S.1    Cao, Y.2    Marcello, J.E.3    Herndon II, J.E.4    McLendon, R.E.5    Desjardins, A.6
  • 200
    • 84891434767 scopus 로고    scopus 로고
    • Lactate-modulated induction of THBS-1 activates transforming growth factor (TGF)-beta2 and migration of glioma cells in vitro
    • Seliger C, Leukel P, Moeckel S, Jachnik B, Lottaz C, Kreutz M, et al: Lactate-modulated induction of THBS-1 activates transforming growth factor (TGF)-beta2 and migration of glioma cells in vitro. PLoS ONE 8:e78935, 2013
    • (2013) PLoS ONE , vol.8
    • Seliger, C.1    Leukel, P.2    Moeckel, S.3    Jachnik, B.4    Lottaz, C.5    Kreutz, M.6
  • 201
    • 78549283855 scopus 로고    scopus 로고
    • Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1
    • Seltzer MJ, Bennett BD, Joshi AD, Gao P, Thomas AG, Ferraris DV, et al: Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1. Cancer Res 70:8981-8987, 2010
    • (2010) Cancer Res , vol.70 , pp. 8981-8987
    • Seltzer, M.J.1    Bennett, B.D.2    Joshi, A.D.3    Gao, P.4    Thomas, A.G.5    Ferraris, D.V.6
  • 202
    • 84883501150 scopus 로고    scopus 로고
    • HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
    • Semenza GL: HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations. J Clin Invest 123:3664-3671, 2013
    • (2013) J Clin Invest , vol.123 , pp. 3664-3671
    • Semenza, G.L.1
  • 203
    • 76049100577 scopus 로고    scopus 로고
    • HIF-1: upstream and downstream of cancer metabolism
    • Semenza GL: HIF-1: upstream and downstream of cancer metabolism. Curr Opin Genet Dev 20:51-56, 2010
    • (2010) Curr Opin Genet Dev , vol.20 , pp. 51-56
    • Semenza, G.L.1
  • 204
    • 35148828429 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 (HIF-1) pathway
    • Semenza GL: Hypoxia-inducible factor 1 (HIF-1) pathway. Sci STKE 2007:cm8, 2007
    • (2007) Sci STKE , vol.2007
    • Semenza, G.L.1
  • 205
    • 3042693287 scopus 로고    scopus 로고
    • Increase of SUMO-1 expression in response to hypoxia: direct interaction with HIF-1alpha in adult mouse brain and heart in vivo
    • Shao R, Zhang FP, Tian F, Anders Friberg P, Wang X, Sjöland H, et al: Increase of SUMO-1 expression in response to hypoxia: direct interaction with HIF-1alpha in adult mouse brain and heart in vivo. FEBS Lett 569:293-300, 2004
    • (2004) FEBS Lett , vol.569 , pp. 293-300
    • Shao, R.1    Zhang, F.P.2    Tian, F.3    Anders Friberg, P.4    Wang, X.5    Sjöland, H.6
  • 206
    • 79951676430 scopus 로고    scopus 로고
    • Ras regulates interleukin-1b-induced HIF-1a transcriptional activity in glioblastoma
    • Sharma V, Dixit D, Koul N, Mehta VS, Sen E: Ras regulates interleukin-1b-induced HIF-1a transcriptional activity in glioblastoma. J Mol Med (Berl) 89:123-136, 2011
    • (2011) J Mol Med (Berl) , vol.89 , pp. 123-136
    • Sharma, V.1    Dixit, D.2    Koul, N.3    Mehta, V.S.4    Sen, E.5
  • 207
    • 42449130564 scopus 로고    scopus 로고
    • Bortezomib inhibits tumor adaptation to hypoxia by stimulating the FIHmediated repression of hypoxia-inducible factor-1
    • Shin DH, Chun YS, Lee DS, Huang LE, Park JW: Bortezomib inhibits tumor adaptation to hypoxia by stimulating the FIHmediated repression of hypoxia-inducible factor-1. Blood 111:3131-3136, 2008
    • (2008) Blood , vol.111 , pp. 3131-3136
    • Shin, D.H.1    Chun, Y.S.2    Lee, D.S.3    Huang, L.E.4    Park, J.W.5
  • 210
    • 38349000624 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1alpha-induced differentiation of myeloid leukemic cells is its transcriptional activity independent
    • Song LP, Zhang J, Wu SF, Huang Y, Zhao Q, Cao JP, et al: Hypoxia-inducible factor-1alpha-induced differentiation of myeloid leukemic cells is its transcriptional activity independent. Oncogene 27:519-527, 2008
    • (2008) Oncogene , vol.27 , pp. 519-527
    • Song, L.P.1    Zhang, J.2    Wu, S.F.3    Huang, Y.4    Zhao, Q.5    Cao, J.P.6
  • 212
    • 0043123069 scopus 로고    scopus 로고
    • Carbonic anhydrase-9 expression levels and prognosis in human breast cancer: association with treatment outcome
    • Span PN, Bussink J, Manders P, Beex LV, Sweep CG: Carbonic anhydrase-9 expression levels and prognosis in human breast cancer: association with treatment outcome. Br J Cancer 89:271-276, 2003
    • (2003) Br J Cancer , vol.89 , pp. 271-276
    • Span, P.N.1    Bussink, J.2    Manders, P.3    Beex, L.V.4    Sweep, C.G.5
  • 213
  • 214
    • 35348964557 scopus 로고    scopus 로고
    • Advances in radiation therapy for brain tumors
    • Stieber VW, Mehta MP: Advances in radiation therapy for brain tumors. Neurol Clin 25:1005-1033, ix, 2007
    • (2007) Neurol Clin , vol.25 , pp. 1005-1033+9
    • Stieber, V.W.1    Mehta, M.P.2
  • 215
    • 21044459993 scopus 로고    scopus 로고
    • Optimal role of temozolomide in the treatment of malignant gliomas
    • Stupp R, van den Bent MJ, Hegi ME: Optimal role of temozolomide in the treatment of malignant gliomas. Curr Neurol Neurosci Rep 5:198-206, 2005
    • (2005) Curr Neurol Neurosci Rep , vol.5 , pp. 198-206
    • Stupp, R.1    van den Bent, M.J.2    Hegi, M.E.3
  • 216
    • 20444456659 scopus 로고    scopus 로고
    • The role of radio- and chemotherapy in glioblastoma
    • Stupp R, Weber DC: The role of radio- and chemotherapy in glioblastoma. Onkologie 28:315-317, 2005
    • (2005) Onkologie , vol.28 , pp. 315-317
    • Stupp, R.1    Weber, D.C.2
  • 217
    • 41149149805 scopus 로고    scopus 로고
    • Differential expression of Glut 1 mRNA and protein levels correlates with increased sensitivity to the glycoconjugated nitric oxide donor (2-glu-SNAP) in different tumor cell types
    • Subbarayan PR, Wang PG, Lampidis TJ, Ardalan B, Braunschweiger P: Differential expression of Glut 1 mRNA and protein levels correlates with increased sensitivity to the glycoconjugated nitric oxide donor (2-glu-SNAP) in different tumor cell types. J Chemother 20:106-111, 2008
    • (2008) J Chemother , vol.20 , pp. 106-111
    • Subbarayan, P.R.1    Wang, P.G.2    Lampidis, T.J.3    Ardalan, B.4    Braunschweiger, P.5
  • 219
    • 84905513649 scopus 로고    scopus 로고
    • Prolyl-4-hydroxylase 2 enhances hypoxia-induced glioblastoma cell death by regulating the gene expression of hypoxia-inducible factor-a
    • Sun W, Jelkmann W, Depping R: Prolyl-4-hydroxylase 2 enhances hypoxia-induced glioblastoma cell death by regulating the gene expression of hypoxia-inducible factor-a. Cell Death Dis 5:e1322, 2014
    • (2014) Cell Death Dis , vol.5
    • Sun, W.1    Jelkmann, W.2    Depping, R.3
  • 220
    • 0031688165 scopus 로고    scopus 로고
    • Tumour hypoxia and vascular density as predictors of metastasis in squamous cell carcinoma of the uterine cervix
    • Sundfør K, Lyng H, Rofstad EK: Tumour hypoxia and vascular density as predictors of metastasis in squamous cell carcinoma of the uterine cervix. Br J Cancer 78:822-827, 1998
    • (1998) Br J Cancer , vol.78 , pp. 822-827
    • Sundfør, K.1    Lyng, H.2    Rofstad, E.K.3
  • 221
    • 84883271078 scopus 로고    scopus 로고
    • Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology
    • Sutendra G, Michelakis ED: Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology. Front Oncol 3:38, 2013
    • (2013) Front Oncol , vol.3 , pp. 38
    • Sutendra, G.1    Michelakis, E.D.2
  • 222
    • 19944431335 scopus 로고    scopus 로고
    • Identification of a novel small-molecule inhibitor of the hypoxia-inducible factor 1 pathway
    • Tan C, de Noronha RG, Roecker AJ, Pyrzynska B, Khwaja F, Zhang Z, et al: Identification of a novel small-molecule inhibitor of the hypoxia-inducible factor 1 pathway. Cancer Res 65:605-612, 2005
    • (2005) Cancer Res , vol.65 , pp. 605-612
    • Tan, C.1    de Noronha, R.G.2    Roecker, A.J.3    Pyrzynska, B.4    Khwaja, F.5    Zhang, Z.6
  • 223
    • 3142534607 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 alpha expression correlates with angiogenesis and unfavorable prognosis in bladder cancer
    • Theodoropoulos VE, Lazaris ACh, Sofras F, Gerzelis I, Tsoukala V, Ghikonti I, et al: Hypoxia-inducible factor 1 alpha expression correlates with angiogenesis and unfavorable prognosis in bladder cancer. Eur Urol 46:200-208, 2004
    • (2004) Eur Urol , vol.46 , pp. 200-208
    • Theodoropoulos, V.E.1    Lazaris, A.C.2    Sofras, F.3    Gerzelis, I.4    Tsoukala, V.5    Ghikonti, I.6
  • 224
    • 2342422295 scopus 로고    scopus 로고
    • Vascular microenvironment in gliomas
    • Vajkoczy P, Menger MD: Vascular microenvironment in gliomas. Cancer Treat Res 117:249-262, 2004
    • (2004) Cancer Treat Res , vol.117 , pp. 249-262
    • Vajkoczy, P.1    Menger, M.D.2
  • 225
    • 0029397625 scopus 로고
    • Cytokines and tumors of the central nervous system
    • Van Meir EG: Cytokines and tumors of the central nervous system. Glia 15:264-288, 1995
    • (1995) Glia , vol.15 , pp. 264-288
    • Van Meir, E.G.1
  • 226
    • 84891273707 scopus 로고    scopus 로고
    • Combined targeting of PDK1 and EGFR triggers regression of glioblastoma by reversing the Warburg effect
    • Velpula KK, Bhasin A, Asuthkar S, Tsung AJ: Combined targeting of PDK1 and EGFR triggers regression of glioblastoma by reversing the Warburg effect. Cancer Res 73:7277-7289, 2013
    • (2013) Cancer Res , vol.73 , pp. 7277-7289
    • Velpula, K.K.1    Bhasin, A.2    Asuthkar, S.3    Tsung, A.J.4
  • 227
    • 59649105538 scopus 로고    scopus 로고
    • Camptothecins: a SAR/QSAR study
    • Verma RP, Hansch C: Camptothecins: a SAR/QSAR study. Chem Rev 109:213-235, 2009
    • (2009) Chem Rev , vol.109 , pp. 213-235
    • Verma, R.P.1    Hansch, C.2
  • 229
    • 0034652620 scopus 로고    scopus 로고
    • High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers
    • Walenta S, Wetterling M, Lehrke M, Schwickert G, Sundfør K, Rofstad EK, et al: High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers. Cancer Res 60:916-921, 2000
    • (2000) Cancer Res , vol.60 , pp. 916-921
    • Walenta, S.1    Wetterling, M.2    Lehrke, M.3    Schwickert, G.4    Sundfør, K.5    Rofstad, E.K.6
  • 230
    • 33744829237 scopus 로고    scopus 로고
    • CCI-779 inhibits rhabdomyosarcoma xenograft growth by an antiangiogenic mechanism linked to the targeting of mTOR/Hif-1alpha/ VEGF signaling
    • Wan X, Shen N, Mendoza A, Khanna C, Helman LJ: CCI-779 inhibits rhabdomyosarcoma xenograft growth by an antiangiogenic mechanism linked to the targeting of mTOR/Hif-1alpha/ VEGF signaling. Neoplasia 8:394-401, 2006
    • (2006) Neoplasia , vol.8 , pp. 394-401
    • Wan, X.1    Shen, N.2    Mendoza, A.3    Khanna, C.4    Helman, L.J.5
  • 231
    • 84899874531 scopus 로고    scopus 로고
    • The role of factor inhibiting HIF (FIH-1) in inhibiting HIF-1 transcriptional activity in glioblastoma multiforme
    • Wang E, Zhang C, Polavaram N, Liu F, Wu G, Schroeder MA, et al: The role of factor inhibiting HIF (FIH-1) in inhibiting HIF-1 transcriptional activity in glioblastoma multiforme. PLoS ONE 9:e86102, 2014
    • (2014) PLoS ONE , vol.9
    • Wang, E.1    Zhang, C.2    Polavaram, N.3    Liu, F.4    Wu, G.5    Schroeder, M.A.6
  • 232
    • 80055009016 scopus 로고    scopus 로고
    • Downregulation of receptor for activated C-kinase 1 (RACK1) suppresses tumor growth by inhibiting tumor cell proliferation and tumor-associated angiogenesis
    • Wang F, Osawa T, Tsuchida R, Yuasa Y, Shibuya M: Downregulation of receptor for activated C-kinase 1 (RACK1) suppresses tumor growth by inhibiting tumor cell proliferation and tumor-associated angiogenesis. Cancer Sci 102:2007-2013, 2011
    • (2011) Cancer Sci , vol.102 , pp. 2007-2013
    • Wang, F.1    Osawa, T.2    Tsuchida, R.3    Yuasa, Y.4    Shibuya, M.5
  • 233
    • 0029051439 scopus 로고
    • Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
    • Wang GL, Jiang BH, Rue EA, Semenza GL: Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci U S A 92:5510-5514, 1995
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 5510-5514
    • Wang, G.L.1    Jiang, B.H.2    Rue, E.A.3    Semenza, G.L.4
  • 234
    • 84897380818 scopus 로고    scopus 로고
    • Prognosis value of HIF-1a expression in patients with non-small cell lung cancer
    • Wang Q, Hu DF, Rui Y, Jiang AB, Liu ZL, Huang LN: Prognosis value of HIF-1a expression in patients with non-small cell lung cancer. Gene 541:69-74, 2014
    • (2014) Gene , vol.541 , pp. 69-74
    • Wang, Q.1    Hu, D.F.2    Rui, Y.3    Jiang, A.B.4    Liu, Z.L.5    Huang, L.N.6
  • 235
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg O: On the origin of cancer cells. Science 123:309-314, 1956
    • (1956) Science , vol.123 , pp. 309-314
    • Warburg, O.1
  • 236
  • 237
    • 0142144338 scopus 로고    scopus 로고
    • The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1alpha and vascular endothelial growth factor formation
    • Welsh SJ, Williams RR, Birmingham A, Newman DJ, Kirkpatrick DL, Powis G: The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1alpha and vascular endothelial growth factor formation. Mol Cancer Ther 2:235-243, 2003
    • (2003) Mol Cancer Ther , vol.2 , pp. 235-243
    • Welsh, S.J.1    Williams, R.R.2    Birmingham, A.3    Newman, D.J.4    Kirkpatrick, D.L.5    Powis, G.6
  • 238
    • 84922572782 scopus 로고    scopus 로고
    • Local delivery of cancer-cell glycolytic inhibitors in highgrade glioma
    • [epub ahead of print]
    • Wicks RT, Azadi J, Mangraviti A, Zhang I, Hwang L, Joshi A, et al: Local delivery of cancer-cell glycolytic inhibitors in highgrade glioma. Neuro Oncol [epub ahead of print], 2014
    • (2014) Neuro Oncol
    • Wicks, R.T.1    Azadi, J.2    Mangraviti, A.3    Zhang, I.4    Hwang, L.5    Joshi, A.6
  • 239
    • 0024315240 scopus 로고
    • Drug resistance in Chinese hamster ovary cells during recovery from severe hypoxia
    • Wilson RE, Keng PC, Sutherland RM: Drug resistance in Chinese hamster ovary cells during recovery from severe hypoxia. J Natl Cancer Inst 81:1235-1240, 1989
    • (1989) J Natl Cancer Inst , vol.81 , pp. 1235-1240
    • Wilson, R.E.1    Keng, P.C.2    Sutherland, R.M.3
  • 240
    • 79958015593 scopus 로고    scopus 로고
    • Targeting metabolic remodeling in glioblastoma multiforme
    • Wolf A, Agnihotri S, Guha A: Targeting metabolic remodeling in glioblastoma multiforme. Oncotarget 1:552-562, 2010
    • (2010) Oncotarget , vol.1 , pp. 552-562
    • Wolf, A.1    Agnihotri, S.2    Guha, A.3
  • 241
    • 79951699777 scopus 로고    scopus 로고
    • Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme
    • Wolf A, Agnihotri S, Micallef J, Mukherjee J, Sabha N, Cairns R, et al: Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme. J Exp Med 208:313-326, 2011
    • (2011) J Exp Med , vol.208 , pp. 313-326
    • Wolf, A.1    Agnihotri, S.2    Micallef, J.3    Mukherjee, J.4    Sabha, N.5    Cairns, R.6
  • 242
    • 79961127669 scopus 로고    scopus 로고
    • Developmental profile and regulation of the glycolytic enzyme hexokinase 2 in normal brain and glioblastoma multiforme
    • Wolf A, Agnihotri S, Munoz D, Guha A: Developmental profile and regulation of the glycolytic enzyme hexokinase 2 in normal brain and glioblastoma multiforme. Neurobiol Dis 44:84-91, 2011
    • (2011) Neurobiol Dis , vol.44 , pp. 84-91
    • Wolf, A.1    Agnihotri, S.2    Munoz, D.3    Guha, A.4
  • 243
    • 84862818535 scopus 로고    scopus 로고
    • Recent advances in hypoxia-inducible factor (HIF)-1 inhibitors
    • Xia Y, Choi HK, Lee K: Recent advances in hypoxia-inducible factor (HIF)-1 inhibitors. Eur J Med Chem 49:24-40, 2012
    • (2012) Eur J Med Chem , vol.49 , pp. 24-40
    • Xia, Y.1    Choi, H.K.2    Lee, K.3
  • 244
    • 12544256565 scopus 로고    scopus 로고
    • Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia
    • Xu RH, Pelicano H, Zhou Y, Carew JS, Feng L, Bhalla KN, et al: Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia. Cancer Res 65:613-621, 2005
    • (2005) Cancer Res , vol.65 , pp. 613-621
    • Xu, R.H.1    Pelicano, H.2    Zhou, Y.3    Carew, J.S.4    Feng, L.5    Bhalla, K.N.6
  • 245
    • 84872266344 scopus 로고    scopus 로고
    • Small ubiquitin-like modifier 1-3 conjugation [corrected] is activated in human astrocytic brain tumors and is required for glioblastoma cell survival
    • (Erratum in Cancer Sci 104:70-77, 2013)
    • Yang W, Wang L, Roehn G, Pearlstein RD, Ali-Osman F, Pan H, et al: Small ubiquitin-like modifier 1-3 conjugation [corrected] is activated in human astrocytic brain tumors and is required for glioblastoma cell survival. Cancer Sci 104:70-77, 2013 (Erratum in Cancer Sci 104:70-77, 2013)
    • (2013) Cancer Sci , vol.104 , pp. 70-77
    • Yang, W.1    Wang, L.2    Roehn, G.3    Pearlstein, R.D.4    Ali-Osman, F.5    Pan, H.6
  • 246
    • 31544469773 scopus 로고    scopus 로고
    • Amphotericin B blunts erythropoietin response to hypoxia by reinforcing FIH-mediated repression of HIF-1
    • Yeo EJ, Ryu JH, Cho YS, Chun YS, Huang LE, Kim MS, et al: Amphotericin B blunts erythropoietin response to hypoxia by reinforcing FIH-mediated repression of HIF-1. Blood 107:916-923, 2006
    • (2006) Blood , vol.107 , pp. 916-923
    • Yeo, E.J.1    Ryu, J.H.2    Cho, Y.S.3    Chun, Y.S.4    Huang, L.E.5    Kim, M.S.6
  • 247
    • 84866424379 scopus 로고    scopus 로고
    • Arylsulfonamide KCN1 inhibits in vivo glioma growth and interferes with HIF signaling by disrupting HIF-1a interaction with cofactors p300/CBP
    • Yin S, Kaluz S, Devi NS, Jabbar AA, de Noronha RG, Mun J, et al: Arylsulfonamide KCN1 inhibits in vivo glioma growth and interferes with HIF signaling by disrupting HIF-1a interaction with cofactors p300/CBP. Clin Cancer Res 18:6623-6633, 2012
    • (2012) Clin Cancer Res , vol.18 , pp. 6623-6633
    • Yin, S.1    Kaluz, S.2    Devi, N.S.3    Jabbar, A.A.4    de Noronha, R.G.5    Mun, J.6
  • 248
    • 0034213146 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor 1alpha in brain tumors: association with angiogenesis, invasion, and progression
    • Zagzag D, Zhong H, Scalzitti JM, Laughner E, Simons JW, Semenza GL: Expression of hypoxia-inducible factor 1alpha in brain tumors: association with angiogenesis, invasion, and progression. Cancer 88:2606-2618, 2000
    • (2000) Cancer , vol.88 , pp. 2606-2618
    • Zagzag, D.1    Zhong, H.2    Scalzitti, J.M.3    Laughner, E.4    Simons, J.W.5    Semenza, G.L.6
  • 249
    • 33646117271 scopus 로고    scopus 로고
    • Evidence that hypoxia-inducible factor-1 (HIF-1) mediates transcriptional activation of interleukin-1beta (IL-1beta) in astrocyte cultures
    • Zhang W, Petrovic JM, Callaghan D, Jones A, Cui H, Howlett C, et al: Evidence that hypoxia-inducible factor-1 (HIF-1) mediates transcriptional activation of interleukin-1beta (IL-1beta) in astrocyte cultures. J Neuroimmunol 174:63-73, 2006
    • (2006) J Neuroimmunol , vol.174 , pp. 63-73
    • Zhang, W.1    Petrovic, J.M.2    Callaghan, D.3    Jones, A.4    Cui, H.5    Howlett, C.6
  • 250
    • 84885173431 scopus 로고    scopus 로고
    • Melatonin antagonizes hypoxia-mediated glioblastoma cell migration and invasion via inhibition of HIF-1a
    • Zhang Y, Liu Q, Wang F, Ling EA, Liu S, Wang L, et al: Melatonin antagonizes hypoxia-mediated glioblastoma cell migration and invasion via inhibition of HIF-1a. J Pineal Res 55:121-130, 2013
    • (2013) J Pineal Res , vol.55 , pp. 121-130
    • Zhang, Y.1    Liu, Q.2    Wang, F.3    Ling, E.A.4    Liu, S.5    Wang, L.6
  • 251
    • 84876737635 scopus 로고    scopus 로고
    • miR-143 inhibits glycolysis and depletes stemness of glioblastoma stemlike cells
    • Zhao S, Liu H, Liu Y, Wu J, Wang C, Hou X, et al: miR-143 inhibits glycolysis and depletes stemness of glioblastoma stemlike cells. Cancer Lett 333:253-260, 2013
    • (2013) Cancer Lett , vol.333 , pp. 253-260
    • Zhao, S.1    Liu, H.2    Liu, Y.3    Wu, J.4    Wang, C.5    Hou, X.6
  • 252
    • 84860258307 scopus 로고    scopus 로고
    • B-elemene inhibits Hsp90/Raf-1 molecular complex inducing apoptosis of glioblastoma cells
    • Zhao YS, Zhu TZ, Chen YW, Yao YQ, Wu CM, Wei ZQ, et al: B-elemene inhibits Hsp90/Raf-1 molecular complex inducing apoptosis of glioblastoma cells. J Neurooncol 107:307-314, 2012
    • (2012) J Neurooncol , vol.107 , pp. 307-314
    • Zhao, Y.S.1    Zhu, T.Z.2    Chen, Y.W.3    Yao, Y.Q.4    Wu, C.M.5    Wei, Z.Q.6
  • 253
    • 0033571682 scopus 로고    scopus 로고
    • Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases
    • Zhong H, De Marzo AM, Laughner E, Lim M, Hilton DA, Zagzag D, et al: Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res 59:5830-5835, 1999
    • (1999) Cancer Res , vol.59 , pp. 5830-5835
    • Zhong, H.1    De Marzo, A.M.2    Laughner, E.3    Lim, M.4    Hilton, D.A.5    Zagzag, D.6
  • 254
    • 84901266379 scopus 로고    scopus 로고
    • Human rhomboid family-1 suppresses oxygen-independent degradation of hypoxia-inducible factor-1a in breast cancer
    • Zhou Z, Liu F, Zhang ZS, Shu F, Zheng Y, Fu L, et al: Human rhomboid family-1 suppresses oxygen-independent degradation of hypoxia-inducible factor-1a in breast cancer. Cancer Res 74:2719-2730, 2014
    • (2014) Cancer Res , vol.74 , pp. 2719-2730
    • Zhou, Z.1    Liu, F.2    Zhang, Z.S.3    Shu, F.4    Zheng, Y.5    Fu, L.6
  • 255
    • 77956572981 scopus 로고    scopus 로고
    • The novel Hsp90 inhibitor NXD30001 induces tumor regression in a genetically engineered mouse model of glioblastoma multiforme
    • Zhu H, Woolfenden S, Bronson RT, Jaffer ZM, Barluenga S, Winssinger N, et al: The novel Hsp90 inhibitor NXD30001 induces tumor regression in a genetically engineered mouse model of glioblastoma multiforme. Mol Cancer Ther 9:2618-2626, 2010
    • (2010) Mol Cancer Ther , vol.9 , pp. 2618-2626
    • Zhu, H.1    Woolfenden, S.2    Bronson, R.T.3    Jaffer, Z.M.4    Barluenga, S.5    Winssinger, N.6
  • 257
    • 84881261950 scopus 로고    scopus 로고
    • Dichloroacetate induces tumor-specific radiosensitivity in vitro but attenuates radiation-induced tumor growth delay in vivo
    • Zwicker F, Kirsner A, Peschke P, Roeder F, Debus J, Huber PE, et al: Dichloroacetate induces tumor-specific radiosensitivity in vitro but attenuates radiation-induced tumor growth delay in vivo. Strahlenther Onkol 189:684-692, 2013
    • (2013) Strahlenther Onkol , vol.189 , pp. 684-692
    • Zwicker, F.1    Kirsner, A.2    Peschke, P.3    Roeder, F.4    Debus, J.5    Huber, P.E.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.