Hypoxia-inducible factor pathway inhibition resolves tumor hypoxia and improves local tumor control after single-dose irradiation

International Journal of Radiation Oncology Biology Physics

Volumn 88, Issue 1, 2014, Pages 159-166

  Helbig, Linda ^a,b   Koi, Lydia ^a,b,c   Brüchner, Kerstin ^b,d   Gurtner, Kristin ^b   Hess Stumpp, Holger ^e   Unterschemmann, Kerstin ^e   Pruschy, Martin ^f   Baumann, Michael ^a,b,c,d   Yaromina, Ala ^a,b,g   Zips, Daniel ^c,h  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^b UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^c Helmholtz Zentrum Dresden Rossendorf ^*  (Germany)

^d INSTITUTE OF ION BEAM PHYSICS AND MATERIALS RESEARCH   (Germany)

^e Global Drug Discovery   (Germany)

^f UNIVERSITY OF ZURICH   (Switzerland)

^g MAASTRICHT UNIVERSITY   (Netherlands)

^h UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MECHANISMS; CHEMORADIATION THERAPIES; HYPOXIA-INDUCIBLE FACTOR 1; HYPOXIA-INDUCIBLE FACTORS; LOCAL TUMOR CONTROL; METHODS AND MATERIALS; MITOCHONDRIAL COMPLEX; SQUAMOUS CELL CARCINOMA;

ANIMALS; IRRADIATION; MAINTENANCE; RADIATION EFFECTS;

TUMORS;

BAY 84 7296; BROXURIDINE; HYPOXIA INDUCIBLE FACTOR; PIMONIDAZOLE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CONTROL; CANCER RADIOTHERAPY; CANCER SIZE; CONTROLLED STUDY; DRUG SYNTHESIS; FEMALE; HEAD AND NECK CARCINOMA; HYPOXIA; IMMUNOHISTOCHEMISTRY; IMMUNOHISTOLOGY; IN VITRO STUDY; IRRADIATION; MALE; MOLECULAR LIBRARY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIOSENSITIVITY; SINGLE DRUG DOSE; SQUAMOUS CELL CARCINOMA; VASCULAR NECROSIS; WESTERN BLOTTING;

AMINES; ANIMALS; BROMODEOXYURIDINE; CARCINOMA, SQUAMOUS CELL; CELL HYPOXIA; CELL NUCLEUS; DOSE FRACTIONATION; ELECTRON TRANSPORT COMPLEX I; FEMALE; HETEROGRAFTS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; KI-67 ANTIGEN; MALE; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; NITROIMIDAZOLES; RADIATION TOLERANCE; RADIATION-SENSITIZING AGENTS; RANDOM ALLOCATION; TUMOR MICROENVIRONMENT;

EID: 84890531155     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2013.09.047     Document Type: Article

References (32)

1. A.J. Majmundar, W.J. Wong, and M.C. Simon Hypoxia-inducible factors and the response to hypoxic stress Mol Cell 40 2010 294 309
2. H. Zhong, A.M. De Marzo, and E. Laughner Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases Cancer Res 59 1999 5830 5835
3. B. Bachtiary, M. Schindl, and R. Potter Overexpression of hypoxia-inducible factor 1alpha indicates diminished response to radiotherapy and unfavorable prognosis in patients receiving radical radiotherapy for cervical cancer Clin Cancer Res 9 2003 2234 2240
4. P. Birner, M. Schindl, and A. Obermair Expression of hypoxia-inducible factor 1alpha in epithelial ovarian tumors: Its impact on prognosis and on response to chemotherapy Clin Cancer Res 7 2001 1661 1668
5. M. Schindl, S.F. Schoppmann, and H. Samonigg Overexpression of hypoxia-inducible factor 1alpha is associated with an unfavorable prognosis in lymph node-positive breast cancer Clin Cancer Res 8 2002 1831 1837
6. D.M. Aebersold, P. Burri, and K.T. Beer Expression of hypoxia-inducible factor-1alpha: A novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer Cancer Res 61 2001 2911 2916
7. M. dos Santos, A.M. Mercante, and I.D. Louro HIF1-alpha expression predicts survival of patients with squamous cell carcinoma of the oral cavity PLoS One 7 2012 e45228
8. D.L. Schwartz, G. Powis, and A. Thitai-Kumar The selective hypoxia inducible factor-1 inhibitor PX-478 provides in vivo radiosensitization through tumor stromal effects Mol Cancer Ther 8 2009 947 958
9. J. Kessler, A. Hahnel, and H. Wichmann HIF-1alpha inhibition by siRNA or chetomin in human malignant glioma cells: Effects on hypoxic radioresistance and monitoring via CA9 expression BMC Cancer 10 2010 605
10. A. Staab, J. Loeffler, and H.M. Said Effects of HIF-1 inhibition by chetomin on hypoxia-related transcription and radiosensitivity in HT 1080 human fibrosarcoma cells BMC Cancer 7 2007 213
11. Z.G. Dikmen, G.C. Gellert, and P. Dogan In vivo and in vitro effects of a HIF-1alpha inhibitor, RX-0047 J Cell Biochem 104 2008 985 994
12. H. Harada, S. Itasaka, and Y. Zhu Treatment regimen determines whether an HIF-1 inhibitor enhances or inhibits the effect of radiation therapy Br J Cancer 100 2009 747 757
13. B.J. Moeller, M.R. Dreher, and Z.N. Rabbani Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity Cancer Cell 8 2005 99 110
14. K.J. Williams, B.A. Telfer, and D. Xenaki Enhanced response to radiotherapy in tumours deficient in the function of hypoxia-inducible factor-1 Radiother Oncol 75 2005 89 98
15. T.W. Meijer, J.H. Kaanders, and P.N. Span Targeting hypoxia, HIF-1, and tumor glucose metabolism to improve radiotherapy efficacy Clin Cancer Res 18 2012 5585 5594
16. K.M. Rouschop, L.J. Dubois, and T.G. Keulers PERK/eIF2alpha signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS Proc Natl Acad Sci U S A 110 2013 4622 4627
17. P. Ellinghaus, I. Heisler, and K. Unterschemmann BAY 87-2243, a highly potent and selective inhibitor of hypoxia-induced gene activation has antitumor activities by inhibition of mitochondrial complex I Cancer Med 2 2013 611 624
18. A. Yaromina, T. Kroeber, and A. Meinzer Exploratory study of the prognostic value of microenvironmental parameters during fractionated irradiation in human squamous cell carcinoma xenografts Int J Radiat Oncol Biol Phys 80 2011 1205 1213
19. F. Li, P. Sonveaux, and Z.N. Rabbani Regulation of HIF-1alpha stability through S-nitrosylation Mol Cell 26 2007 63 74
20. B.J. Moeller, Y. Cao, and C.Y. Li Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: Role of reoxygenation, free radicals, and stress granules Cancer Cell 5 2004 429 441
21. H. Harada, M. Inoue, and S. Itasaka Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels Nat Commun 3 2012 783
22. M. Krause, B. Kummer, and A. Deparade Simultaneous PLK1 inhibition improves local tumour control after fractionated irradiation Radiother Oncol 108 2013 422 428
23. K. Zaleska, K. Bruechner, and M. Baumann Tumour-infiltrating CD11b+ myelomonocytes and response to fractionated irradiation of human squamous cell carcinoma (hSCC) xenografts Radiother Oncol 101 2011 80 85
24. L. Helbig, A. Yaromina, and S.N. Sriramareddy Prognostic value of HIF-1alpha expression during fractionated irradiation Strahlenther Onkol 188 2012 1031 1037
25. M. Krause, J. Prager, and X. Zhou EGFR-TK inhibition before radiotherapy reduces tumour volume but does not improve local control: Differential response of cancer stem cells and nontumourigenic cells? Radiother Oncol 83 2007 316 325
26. A. Yaromina, D. Zips, and H.D. Thames Pimonidazole labelling and response to fractionated irradiation of five human squamous cell carcinoma (hSCC) lines in nude mice: The need for a multivariate approach in biomarker studies Radiother Oncol 81 2006 122 129
27. D.L. Schwartz, J.A. Bankson, and R. Lemos Jr. Radiosensitization and stromal imaging response correlates for the HIF-1 inhibitor PX-478 given with or without chemotherapy in pancreatic cancer Mol Cancer Ther 9 2010 2057 2067
28. R.K. Jain Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy Science 307 2005 58 62
29. T.W. Secomb, R. Hsu, and E.T. Ong Analysis of the effects of oxygen supply and demand on hypoxic fraction in tumors Acta Oncol 34 1995 313 316
30. V. Quennet, A. Yaromina, and D. Zips Tumor lactate content predicts for response to fractionated irradiation of human squamous cell carcinomas in nude mice Radiother Oncol 81 2006 130 135
31. K. Goetze, S.S. Meyer, and A. Yaromina Glycolysis-related gene induction and ATP reduction during fractionated irradiation: Markers for radiation responsiveness of human tumor xenografts Strahlenther Onkol 189 2013 782 788
32. J.M. Brown, M. Diehn, and B.W. Loo Jr. Stereotactic ablative radiotherapy should be combined with a hypoxic cell radiosensitizer Int J Radiat Oncol Biol Phys 78 2010 323 327