Accumulation of Krebs cycle intermediates and over-expression of HIF1α in tumours which result from germline FH and SDH mutations

Human Molecular Genetics

Volumn 14, Issue 15, 2005, Pages 2231-2239

  Pollard, P J ^a   Briere J J ^b   Alam, N A ^a,c   Barwell, J ^d   Barclay, E ^a   Wortham, N C ^a   Hunt, T ^a   Mitchell, M ^a   Olpin, S ^e   Moat, S J ^f   Hargreaves, I P ^g   Heales, S J ^g   Chung, Y L ⁱ   Griffiths, J R ⁱ   Dalgleish, A ^h   McGrath, J A ^c   Gleeson, M J ^d   Hodgson, S V ^h   Poulsom, R ^a   Rustin, P ^b   Tomlinson, Ian P M ^a   more..

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b HÔPITAL ROBERT DEBRÉ   (France)

^c ST THOMAS HOSPITAL   (United Kingdom)

^d GUY S HOSPITAL   (United Kingdom)

^e SHEFFIELD CHILDREN S HOSPITAL   (United Kingdom)

^f UNIVERSITY HOSPITAL OF WALES   (United Kingdom)

^g National Hospital   (United Kingdom)

^h ST GEORGE S HOSPITAL   (United Kingdom)

ⁱ Biomedical Magnetic Resonance Research Group   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

FUMARATE HYDRATASE; HYPOXIA INDUCIBLE FACTOR 1; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; REACTIVE OXYGEN METABOLITE; SUCCINATE DEHYDROGENASE; VASCULOTROPIN;

ARTICLE; CANCER SUSCEPTIBILITY; CAPILLARY DENSITY; CARCINOGENESIS; CITRIC ACID CYCLE; CONTROLLED STUDY; DATA ANALYSIS; ENZYME DEFICIENCY; ENZYME INHIBITION; GENE ACTIVATION; GENE OVEREXPRESSION; GENE TARGETING; GERM LINE; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOTHESIS; IN VIVO STUDY; KIDNEY CARCINOMA; LEIOMYOMA; MOLECULAR STABILITY; MUTATION; PARAGANGLIOMA; PHEOCHROMOCYTOMA; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

CARCINOMA, RENAL CELL; CITRIC ACID CYCLE; FEMALE; FUMARATE HYDRATASE; GERM-LINE MUTATION; HUMANS; LEIOMYOMA; NEOPLASMS; PARAGANGLIOMA; SUCCINATE DEHYDROGENASE; TUMOR CELLS, CULTURED; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 26444570010     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddi227     Document Type: Article

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