메뉴 건너뛰기




Volumn 2, Issue 9, 2002, Pages 673-682

Molecular basis of the VHL hereditary cancer syndrome

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; GROWTH FACTOR; HYPOXIA INDUCIBLE FACTOR 1; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROTEASOME; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR ALPHA; VASCULOTROPIN; LIGASE; TUMOR SUPPRESSOR PROTEIN; UBIQUITIN PROTEIN LIGASE; VHL PROTEIN, HUMAN; VON HIPPEL LINDAU PROTEIN;

EID: 0036718539     PISSN: 1474175X     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrc885     Document Type: Review
Times cited : (726)

References (145)
  • 1
    • 0000020119 scopus 로고
    • Intra-ocular growths (two cases, brother and sister, with peculiar vascular new growth, probably retinal, affecting both eyes)
    • Collins, E. T. Intra-ocular growths (two cases, brother and sister, with peculiar vascular new growth, probably retinal, affecting both eyes). Trans. Ophthalmol. Soc. UK 14, 141-149 (1894).
    • (1894) Trans. Ophthalmol. Soc. UK , vol.14 , pp. 141-149
    • Collins, E.T.1
  • 2
    • 34347163881 scopus 로고
    • Ueber eine sehr seltene Erkrankung der Nethaut
    • von Hippel, E. Ueber eine sehr seltene Erkrankung der Nethaut. Graefe Arch. Ophthalmol. 59, 83-106 (1904).
    • (1904) Graefe Arch. Ophthalmol. , vol.59 , pp. 83-106
    • Von Hippel, E.1
  • 3
    • 0000768725 scopus 로고
    • Zur Frage der Angiomatosis Retinae und Ihrer Hirncomplikation
    • Lindau, A. Zur Frage der Angiomatosis Retinae und Ihrer Hirncomplikation. Acta Ophthalmol. 4, 193-226 (1927).
    • (1927) Acta Ophthalmol. , vol.4 , pp. 193-226
    • Lindau, A.1
  • 4
    • 0031837459 scopus 로고    scopus 로고
    • Haemangioblastoma of the central nervous system in von Hippel-Lindau disease
    • Richard, S., Campello, C., Taillandier, L., Parker, F. & Resche, F. Haemangioblastoma of the central nervous system in von Hippel-Lindau disease. J. Int. Med. 243, 547-553 (1998).
    • (1998) J. Int. Med. , vol.243 , pp. 547-553
    • Richard, S.1    Campello, C.2    Taillandier, L.3    Parker, F.4    Resche, F.5
  • 5
    • 0031445126 scopus 로고    scopus 로고
    • Von Hippel-Lindau disease
    • Maher, E. & Kaelin, W. G. von Hippel-Lindau disease. Medicine 76, 381-391 (1997).
    • (1997) Medicine , vol.76 , pp. 381-391
    • Maher, E.1    Kaelin, W.G.2
  • 6
    • 0023865666 scopus 로고
    • Von Hippel-Lindau disease maps to the region of chromosome 3 associated with renal cell carcinoma
    • Seizinger, B. R. et al. Von Hippel-Lindau disease maps to the region of chromosome 3 associated with renal cell carcinoma. Nature 332, 268-269 (1988).
    • (1988) Nature , vol.332 , pp. 268-269
    • Seizinger, B.R.1
  • 7
    • 0027240519 scopus 로고
    • Identification of the von Hippel-Lindau disease tumor suppressor gene
    • Latif, F. et al. Identification of the von Hippel-Lindau disease tumor suppressor gene. Science 260, 1317-1320 (1993). Describes the identification and cloning of the VHL tumour-suppressor gene. The gene was authenticated by the demonstration of intragenic mutations in affected members of VHL kindreds.
    • (1993) Science , vol.260 , pp. 1317-1320
    • Latif, F.1
  • 8
    • 0034192719 scopus 로고    scopus 로고
    • Comparative sequence analysis of the VHL tumor suppressor gene
    • Woodward, E. et al. Comparative sequence analysis of the VHL tumor suppressor gene. Genomics 65, 253-265 (2000).
    • (2000) Genomics , vol.65 , pp. 253-265
    • Woodward, E.1
  • 9
    • 17944375360 scopus 로고    scopus 로고
    • C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
    • Epstein, A. et al. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 107, 43-54 (2001). This paper, along with reference 10, shows that the C. elegans and Drosophila egl-9 genes, hydroxylate the HIF-α proteins that are identified in these two species, respectively, and that the three human EGL-9 orthologues can hydroxylate human HIF-1α in vitro.
    • (2001) Cell , vol.107 , pp. 43-54
    • Epstein, A.1
  • 10
    • 0035834409 scopus 로고    scopus 로고
    • A conserved family of prolyl-4- hydroxylases that modify HIF
    • Bruick, R. & McKnight, S. A conserved family of prolyl-4- hydroxylases that modify HIF. Science 294, 1337-1340 (2001).
    • (2001) Science , vol.294 , pp. 1337-1340
    • Bruick, R.1    McKnight, S.2
  • 11
    • 7844234770 scopus 로고    scopus 로고
    • Improved detection of germline mutations in the von Hippel-Lindau disease tumor suppressor gene
    • Stolle, C. et al. Improved detection of germline mutations in the von Hippel-Lindau disease tumor suppressor gene. Hum. Mutat. 12, 417-423 (1998).
    • (1998) Hum. Mutat. , vol.12 , pp. 417-423
    • Stolle, C.1
  • 12
    • 0028981766 scopus 로고
    • Germline mutations in the von Hippel-Lindau disease tumor suppressor gene: Correlations with phenotype
    • Chen, F. et al. Germline mutations in the von Hippel-Lindau disease tumor suppressor gene: correlations with phenotype. Hum. Mutat. 5, 66-75 (1995).
    • (1995) Hum. Mutat. , vol.5 , pp. 66-75
    • Chen, F.1
  • 13
    • 16144365122 scopus 로고    scopus 로고
    • Germline mutations in the von Hippel-Lindau (VHL) gene in families from North America, Europe, and Japan
    • Zbar, B. et al. Germline mutations in the von Hippel-Lindau (VHL) gene in families from North America, Europe, and Japan. Hum. Mutat. 8, 348-357 (1996).
    • (1996) Hum. Mutat. , vol.8 , pp. 348-357
    • Zbar, B.1
  • 14
    • 0031834186 scopus 로고    scopus 로고
    • Genotype-phenotype correlations in von Hippel-Lindau disease
    • Neumann, H. & Bender, B. Genotype-phenotype correlations in von Hippel-Lindau disease. J. Intern. Med 243, 541-545 (1998).
    • (1998) J. Intern. Med. , vol.243 , pp. 541-545
    • Neumann, H.1    Bender, B.2
  • 15
    • 0027938458 scopus 로고
    • Somatic mutations of the von Hippel-Lindau tumor supressor gene in sporadic central nervous systems hemangioblastomas
    • Kanno, H. et al. Somatic mutations of the von Hippel-Lindau tumor supressor gene in sporadic central nervous systems hemangioblastomas. Cancer Res. 54, 4845-4847 (1994).
    • (1994) Cancer Res. , vol.54 , pp. 4845-4847
    • Kanno, H.1
  • 16
    • 0033258130 scopus 로고    scopus 로고
    • Germline and somatic mutations in von Hippel-Lindau disease gene and its significance in the development of kidney cancer
    • Shuin, T. et al. Germline and somatic mutations in von Hippel-Lindau disease gene and its significance in the development of kidney cancer. Contrib. Nephrol. 128, 1-10 (1999).
    • (1999) Contrib. Nephrol. , vol.128 , pp. 1-10
    • Shuin, T.1
  • 17
    • 0027954044 scopus 로고
    • Mutations of the VHL tumour suppressor gene in renal carcinoma
    • Gnarra, J. R. et al. Mutations of the VHL tumour suppressor gene in renal carcinoma. Nature Genet. 7, 85-90 (1994).
    • (1994) Nature Genet. , vol.7 , pp. 85-90
    • Gnarra, J.R.1
  • 18
    • 0030958304 scopus 로고    scopus 로고
    • von Hippel-Lindau gene deletion detected in the stromal cell component of a cerebellar hemangioblastoma associated with von Hippel-Lindau disease
    • Vortmeyer, A. et al. von Hippel-Lindau gene deletion detected in the stromal cell component of a cerebellar hemangioblastoma associated with von Hippel-Lindau disease. Hum. Pathol. 28, 540-543 (1997).
    • (1997) Hum. Pathol. , vol.28 , pp. 540-543
    • Vortmeyer, A.1
  • 19
    • 0028954688 scopus 로고
    • A microscopic dissection technique for archival DNA analysis of specific cell populations in lesions < 1mm in size
    • Zhuang, Z. et al. A microscopic dissection technique for archival DNA analysis of specific cell populations in lesions <1mm in size. Am. J. Path. 146, 620-625 (1995).
    • (1995) Am. J. Path. , vol.146 , pp. 620-625
    • Zhuang, Z.1
  • 20
    • 0029759214 scopus 로고    scopus 로고
    • Detection of von Hippel-Lindau disease gene mutations in paraffin-embedded sporadic renal cell carcinoma specimens
    • Zhuang, Z. et al. Detection of von Hippel-Lindau disease gene mutations in paraffin-embedded sporadic renal cell carcinoma specimens. Modern Pathol. 9. 836-842 (1996).
    • (1996) Modern Pathol. , vol.9 , pp. 836-842
    • Zhuang, Z.1
  • 21
    • 0031776704 scopus 로고    scopus 로고
    • Inactivation of the von Hippel-Lindau (VHL) tumour suppressor gene and allelic losses at chromosome arm 3p in primary renal cell carcinoma: Evidence for a VHL-independent pathway in clear cell renal tumourigenesis
    • Clifford, S., Prowse, A., Affara, N., Buys, C. & Maher, E. Inactivation of the von Hippel-Lindau (VHL) tumour suppressor gene and allelic losses at chromosome arm 3p in primary renal cell carcinoma: evidence for a VHL-independent pathway in clear cell renal tumourigenesis. Genes Chromosom. Cancer 22, 200-209 (1998).
    • (1998) Genes Chromosom. Cancer , vol.22 , pp. 200-209
    • Clifford, S.1    Prowse, A.2    Affara, N.3    Buys, C.4    Maher, E.5
  • 22
    • 0028587585 scopus 로고
    • Somatic mutations of the von Hippel-Lindau disease tumor suppressor gene in non-familial clear cell renal carcinoma
    • Foster, K. et al. Somatic mutations of the von Hippel-Lindau disease tumor suppressor gene in non-familial clear cell renal carcinoma. Hum. Mol. Genet. 3, 2169-2173 (1994).
    • (1994) Hum. Mol. Genet. , vol.3 , pp. 2169-2173
    • Foster, K.1
  • 23
    • 0032970571 scopus 로고    scopus 로고
    • Mutations of the VHL gene in sporadic renal cell carcinoma: Definition of a risk factor for VHL patients to develop an RCC
    • Gallou, C. et al. Mutations of the VHL gene in sporadic renal cell carcinoma: definition of a risk factor for VHL patients to develop an RCC. Hum. Mutat. 13, 464-475 (1999).
    • (1999) Hum. Mutat. , vol.13 , pp. 464-475
    • Gallou, C.1
  • 24
    • 0028072991 scopus 로고
    • Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma
    • Herman, J. G. et al. Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma. Proc. Natl Acad. Sci. USA 91, 9700-9704 (1994).
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 9700-9704
    • Herman, J.G.1
  • 25
    • 0029847090 scopus 로고    scopus 로고
    • Allelic deletions of the VHL gene detected in multiple microscopic clear cell renal lesions in von Hippel-Lindau disease patients
    • Lubensky I. A. et al. Allelic deletions of the VHL gene detected in multiple microscopic clear cell renal lesions in von Hippel-Lindau disease patients. Am. J. Pathol. 149, 2089-2094 (1996).
    • (1996) Am. J. Pathol. , vol.149 , pp. 2089-2094
    • Lubensky, I.A.1
  • 26
    • 0028235907 scopus 로고
    • Frequent somatic mutations and loss of heterozygosity of the von Hippel-Lindau tumor suppressor gene in primary human renal cell carcinomas
    • Shuin, T. et al. Frequent somatic mutations and loss of heterozygosity of the von Hippel-Lindau tumor suppressor gene in primary human renal cell carcinomas. Cancer Res. 54, 2852-2855 (1994).
    • (1994) Cancer Res. , vol.54 , pp. 2852-2855
    • Shuin, T.1
  • 27
    • 0027986502 scopus 로고
    • Germ-line mutations in the von Hippel-Lindau tumor suppressor gene are similar to somatic von Hippel-Lindau abberations in sporadic renal cell carcinoma
    • Whaley, J. M. et al. Germ-line mutations in the von Hippel-Lindau tumor suppressor gene are similar to somatic von Hippel-Lindau abberations in sporadic renal cell carcinoma. Am. J. Hum. Genet. 55, 1092-1102 (1994).
    • (1994) Am. J. Hum. Genet. , vol.55 , pp. 1092-1102
    • Whaley, J.M.1
  • 28
    • 0037046659 scopus 로고    scopus 로고
    • Germ-line mutations in nonsyndromic pheochromocytoma
    • Neumann, H. et al. Germ-line mutations in nonsyndromic pheochromocytoma. N. Engl. J. Med. 343, 1459-1466 (2002).
    • (2002) N. Engl. J. Med. , vol.343 , pp. 1459-1466
    • Neumann, H.1
  • 29
    • 0027508442 scopus 로고
    • Pheochromocytomas, multiple endocrine neoplasia type 2, and von Hippel-Lindau disease
    • Neumann, H. P. H. et al. Pheochromocytomas, multiple endocrine neoplasia type 2, and von Hippel-Lindau disease. N. Engl. J. Med. 329, 1531-1538 (1993).
    • (1993) N. Engl. J. Med. , vol.329 , pp. 1531-1538
    • Neumann, H.P.H.1
  • 30
    • 0034485464 scopus 로고    scopus 로고
    • Differential genetic alterations in von Hippel-Lindau syndrome-associated and sporadic pheochromocytomas
    • Bender, B. et al. Differential genetic alterations in von Hippel-Lindau syndrome-associated and sporadic pheochromocytomas. J. Clin. Endocrinol. Metab. 85, 4568-4574 (2000).
    • (2000) J. Clin. Endocrinol. Metab. , vol.85 , pp. 4568-4574
    • Bender, B.1
  • 31
    • 0030804006 scopus 로고    scopus 로고
    • Genetic predisposition to phaeochromocytoma: Analysis of candidate genes GDNF, RET and VHL
    • Woodward, E. et al. Genetic predisposition to phaeochromocytoma: analysis of candidate genes GDNF, RET and VHL. Hum. Mol. Genet. 6, 1051-1056 (1997).
    • (1997) Hum. Mol. Genet. , vol.6 , pp. 1051-1056
    • Woodward, E.1
  • 32
    • 0031298741 scopus 로고    scopus 로고
    • Sporadic phaeochromocytomas are rarely associated with germline mutations in the von Hippel-Lindau and RET genes
    • Bar, M. et al. Sporadic phaeochromocytomas are rarely associated with germline mutations in the von Hippel-Lindau and RET genes. Clin. Endocrincol. 47, 707-712 (1997).
    • (1997) Clin. Endocrincol. , vol.47 , pp. 707-712
    • Bar, M.1
  • 33
    • 0030781576 scopus 로고    scopus 로고
    • Sporadic pheochromocytomas are rarely associated with germline mutations in the VHL tumor suppressor gene or the RET proto oncogene
    • Brauch, H. et al. Sporadic pheochromocytomas are rarely associated with germline mutations in the VHL tumor suppressor gene or the RET protooncogene. J. Clin. Endocrinol. Metab. 82, 4101-4104 (1997).
    • (1997) J. Clin. Endocrinol. Metab. , vol.82 , pp. 4101-4104
    • Brauch, H.1
  • 35
    • 0032578357 scopus 로고    scopus 로고
    • pVHL19 is a biologically active product of the von Hippel-Lindau gene arising from internal translation initiation
    • Iliopoulos, O., Ohh, M. & Kaelin, W. pVHL19 is a biologically active product of the von Hippel-Lindau gene arising from internal translation initiation. Proc. Natl Acad. Sci. USA 95, 11661-11666 (1998).
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 11661-11666
    • Iliopoulos, O.1    Ohh, M.2    Kaelin, W.3
  • 36
    • 0033602089 scopus 로고    scopus 로고
    • Alternate choice of initiation codon produces a biologically active product of the von Hippel-Lindau gene with tumor suppressor activity
    • Blankenship, C., Naglich, J., Whaley, J., Seizinger, B. & Kley, N. Alternate choice of initiation codon produces a biologically active product of the von Hippel-Lindau gene with tumor suppressor activity. Oncogene 18, 1529-1535 (1999).
    • (1999) Oncogene , vol.18 , pp. 1529-1535
    • Blankenship, C.1    Naglich, J.2    Whaley, J.3    Seizinger, B.4    Kley, N.5
  • 37
    • 0032555217 scopus 로고    scopus 로고
    • A second major native von Hippel-Lindau gene product, initiated from an internal translation start site, functions as a tumor suppressor
    • Schoenfeld, A., Davidowitz, E. & Burk, R. A second major native von Hippel-Lindau gene product, initiated from an internal translation start site, functions as a tumor suppressor. Proc. Natl Acad. Sci. USA 95, 8817-8822 (1998).
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 8817-8822
    • Schoenfeld, A.1    Davidowitz, E.2    Burk, R.3
  • 38
    • 0029772338 scopus 로고    scopus 로고
    • Expression pattern of the von Hippel-Lindau protein in human tissues
    • Los, M. et al. Expression pattern of the von Hippel-Lindau protein in human tissues. Lab. Invest. 75, 231-238 (1996).
    • (1996) Lab. Invest. , vol.75 , pp. 231-238
    • Los, M.1
  • 39
    • 0030948396 scopus 로고    scopus 로고
    • Immunostaining of the von Hippel-Lindau gene product (pVHL) in normal and neoplastic human tissues
    • Corless, C. L., Kibel, A., Iliopoulos, O. & Kaelin, W. G. J. Immunostaining of the von Hippel-Lindau gene product (pVHL) in normal and neoplastic human tissues. Hum. Pathol. 28, 459-464 (1997).
    • (1997) Hum. Pathol. , vol.28 , pp. 459-464
    • Corless, C.L.1    Kibel, A.2    Iliopoulos, O.3    Kaelin, W.G.J.4
  • 40
    • 0344026345 scopus 로고    scopus 로고
    • Transcription-dependent nuclear-cytoplasmic trafficking is required for the function of the von Hippel-Lindau tumor suppressor protein
    • Lee, S. et al. Transcription-dependent nuclear-cytoplasmic trafficking is required for the function of the von Hippel-Lindau tumor suppressor protein. Mol. Cell. Biol. 19, 1486-1497 (1999).
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 1486-1497
    • Lee, S.1
  • 41
    • 0034708802 scopus 로고    scopus 로고
    • Ran-mediated nuclear export of the von Hippel-Lindau tumor suppressor protein occurs independent of its assembly with cullin- 2
    • Groulx, I., Bonicalzi, M. ≈ Lee, S. Ran-mediated nuclear export of the von Hippel-Lindau tumor suppressor protein occurs independent of its assembly with cullin-2. J. Biol. Chem. 275, 8991-9000 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 8991-9000
    • Groulx, I.1    Bonicalzi, M.2    Lee, S.3
  • 42
    • 0035847050 scopus 로고    scopus 로고
    • Role of exon 2-encoded β-domain of the von Hippel-Lindau tumor suppressor protein
    • Bonicalzi, M., Groulx, I., de Paulsen, N. & Lee, S. Role of exon 2-encoded β-domain of the von Hippel-Lindau tumor suppressor protein. J. Biol. Chem. 12, 1407-1416 (2001).
    • (2001) J. Biol. Chem. , vol.12 , pp. 1407-1416
    • Bonicalzi, M.1    Groulx, I.2    De Paulsen, N.3    Lee, S.4
  • 43
    • 0029028652 scopus 로고
    • Characterization of the VHL tumor suppressor gene product: Localization, complex formation, and the effect of natural inactivating mutations
    • Duan, D. R. et al. Characterization of the VHL tumor suppressor gene product: localization, complex formation, and the effect of natural inactivating mutations. Proc. Natl Acad. Sci. USA 92, 6495-6499 (1995).
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 6495-6499
    • Duan, D.R.1
  • 44
    • 0029126892 scopus 로고
    • Inhibition of transcriptional elongation by the VHL tumor suppressor protein
    • Duan, D. R. et al. Inhibition of transcriptional elongation by the VHL tumor suppressor protein. Science 269, 1402-1406 (1995). This paper and reference 47 were the first to show that pVHL binds to elongins B and C.
    • (1995) Science , vol.269 , pp. 1402-1406
    • Duan, D.R.1
  • 45
    • 0030953635 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins
    • Pause, A. et al. The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins. Proc. Natl Acad. Sci. USA 94, 2156-2161 (1997). This paper and reference 48 were the first to show that the pVHL complex also contains CUL2, and therefore provided an indication that pVHL might be involved in polyubiquitylation.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 2156-2161
    • Pause, A.1
  • 46
    • 0033578405 scopus 로고    scopus 로고
    • Studying interactions of four proteins in the yeast two-hybrid system: Structural resemblance of the pVHL/elongin BC/hCUL-2 complex with the ubiquitin ligase complex SKP1/cullin/F-box protein
    • Pause, A., Peterson, B., Schaffar, G., Stearman, R. & Klausner, R. Studying interactions of four proteins in the yeast two-hybrid system: structural resemblance of the pVHL/elongin BC/hCUL-2 complex with the ubiquitin ligase complex SKP1/cullin/F-box protein. Proc. Natl Acad. Sci. USA 96, 9533-9538 (1999).
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 9533-9538
    • Pause, A.1    Peterson, B.2    Schaffar, G.3    Stearman, R.4    Klausner, R.5
  • 47
    • 0029147430 scopus 로고
    • Binding of the von Hippel-Lindau tumor suppressor protein to elongin B and C
    • Kibel, A., Iliopoulos, O., DeCaprio, J. D. & Kaelin, W. G. Binding of the von Hippel-Lindau tumor suppressor protein to elongin B and C. Science 269, 1444-1446 (1995).
    • (1995) Science , vol.269 , pp. 1444-1446
    • Kibel, A.1    Iliopoulos, O.2    DeCaprio, J.D.3    Kaelin, W.G.4
  • 48
    • 0031907152 scopus 로고    scopus 로고
    • Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau protein requires binding to complexes containing elongins B/C and Cul 2
    • Lonergan, K. M. et al. Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau protein requires binding to complexes containing elongins B/C and Cul2. Mol. Cell. Biol. 18, 732-741 (1998).
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 732-741
    • Lonergan, K.M.1
  • 49
    • 0028826589 scopus 로고
    • Cellular proteins that bind the von Hippel-Lindau disease gene product: Mapping of binding domains and the effect of missense mutations
    • Kishida, T., Stackhouse, T. M., Chen, F., Lerman, M. I. & Zbar B. Cellular proteins that bind the von Hippel-Lindau disease gene product: mapping of binding domains and the effect of missense mutations. Cancer Res. 55, 4544-4548 (1995).
    • (1995) Cancer Res. , vol.55 , pp. 4544-4548
    • Kishida, T.1    Stackhouse, T.M.2    Chen, F.3    Lerman, M.I.4    Zbar, B.5
  • 50
    • 0030602813 scopus 로고    scopus 로고
    • SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box
    • Bai, C. et al. SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box. Cell 86, 263-274 (1996).
    • (1996) Cell , vol.86 , pp. 263-274
    • Bai, C.1
  • 51
    • 0033279836 scopus 로고    scopus 로고
    • SCF Cullin/Ring H2-based ubiquitin ligases
    • Deshaies, R. SCF and Cullin/Ring H2-based ubiquitin ligases. Annu. Rev. Cell Dev. Biol. 15, 435-467 (1999).
    • (1999) Annu. Rev. Cell Dev. Biol. , vol.15 , pp. 435-467
    • Deshaies, R.1
  • 52
    • 0033574737 scopus 로고    scopus 로고
    • Structure of the VHL-elongin-C-elongin-B complex: Implications for VHL tumor suppressor function
    • Stebbins, C. E., Kaelin. W. G. & Pavletich, N. P. Structure of the VHL-elongin-C-elongin-B complex: implications for VHL tumor suppressor function. Science 284, 455-461 (1999). This paper described the three-dimensional structure of the pVHL-elongin-B-elongin-C complex, which revealed the presence of two frequently mutated subdomains, α and β.
    • (1999) Science , vol.284 , pp. 455-461
    • Stebbins, C.E.1    Kaelin, W.G.2    Pavletich, N.P.3
  • 53
    • 0033565672 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity
    • Lisztwan, J., Imbert, G., Wirbelauer, C., Gstalger, M. & Krek, W. The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity. Genes Dev. 13, 1822-1833 (1999).
    • (1999) Genes Dev. , vol.13 , pp. 1822-1833
    • Lisztwan, J.1    Imbert, G.2    Wirbelauer, C.3    Gstalger, M.4    Krek, W.5
  • 54
    • 0033607291 scopus 로고    scopus 로고
    • Identification of the von Hippel-Lindau tumor-suppressor protein as part of an active E 3 ubiquitin ligase complex
    • Iwai, K. et al. Identification of the von Hippel-Lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex. Proc. Natl Acad. Sci. USA 96, 12436-12441 (1999).
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 12436-12441
    • Iwai, K.1
  • 55
    • 0033597443 scopus 로고    scopus 로고
    • Rbx 1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase
    • Kamura, T. et al. Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase. Science 284, 657-661 (1999).
    • (1999) Science , vol.284 , pp. 657-661
    • Kamura, T.1
  • 56
    • 0029920054 scopus 로고    scopus 로고
    • Reversion of deregulated expression of vascular endothelial growth factor in human renal carcinoma cells by von Hippel-Lindau tumor suppressor protein
    • Siemeister, G. et al. Reversion of deregulated expression of vascular endothelial growth factor in human renal carcinoma cells by von Hippel-Lindau tumor suppressor protein. Cancer Res. 56, 2299-2301 (1996).
    • (1996) Cancer Res. , vol.56 , pp. 2299-2301
    • Siemeister, G.1
  • 57
    • 0029785838 scopus 로고    scopus 로고
    • Post-transcriptional regulation of vascular endothelial growth factor mRNA by the VHL tumor suppressor gene product
    • Gnarra, J. R. et al. Post-transcriptional regulation of vascular endothelial growth factor mRNA by the VHL tumor suppressor gene product. Proc. Natl Acad. Sci. USA 93, 10589-10594 (1996).
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 10589-10594
    • Gnarra, J.R.1
  • 58
    • 0030831655 scopus 로고    scopus 로고
    • Putative control of angiogenesis in hemangioblastomas by the von Hippel-Lindau tumor suppressor gene
    • Stratmann, R., Krieg, M., Haas, R. & Plate, K. Putative control of angiogenesis in hemangioblastomas by the von Hippel-Lindau tumor suppressor gene. J. Neuropathol. Exp. Neurol. 56, 1242-1252 (1997).
    • (1997) J. Neuropathol. Exp. Neurol. , vol.56 , pp. 1242-1252
    • Stratmann, R.1    Krieg, M.2    Haas, R.3    Plate, K.4
  • 59
    • 0029785321 scopus 로고    scopus 로고
    • Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein
    • Iliopoulos, O., Jiang, C., Levy, A. P., Kaelin, W. G. & Goldberg, M. A. Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein. Proc. Natl Acad. Sci. USA 93, 10595-10599 (1996). This paper showed that cells lacking pVHL produced high levels of hypoxia-inducible mRNAs irrespective of changes in oxygen. In keeping with this, references 56 and 57 reported that cells lacking pVHL overproduce VEGF mRNA.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 10595-10599
    • Iliopoulos, O.1    Jiang, C.2    Levy, A.P.3    Kaelin, W.G.4    Goldberg, M.A.5
  • 60
    • 0033233243 scopus 로고    scopus 로고
    • 2 homeostasis by hypoxia-inducible factor 1
    • 2 homeostasis by hypoxia-inducible factor 1. Annu. Rev. Cell Dev. Biol. 15, 551-578 (1999).
    • (1999) Annu. Rev. Cell Dev. Biol. , vol.15 , pp. 551-578
    • Semenza, G.1
  • 61
    • 0033587146 scopus 로고    scopus 로고
    • The von Hippel-Lindau gene product is necessary for oxgyen-dependent proteolysis of hypoxia-inducible factor-α subunits
    • Maxwell, R. et al. The von Hippel-Lindau gene product is necessary for oxgyen-dependent proteolysis of hypoxia-inducible factor-α subunits. Nature 399, 271-275 (1999). A landmark paper showing that cells lacking pVHL do not degrade HIF-α subunits.
    • (1999) Nature , vol.399 , pp. 271-275
    • Maxwell, R.1
  • 62
    • 0034682783 scopus 로고    scopus 로고
    • Hypoxia inducible factor-α binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein
    • Cockman, M. et al. Hypoxia inducible factor-α binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein. J. Biol. Chem. 275, 25733-25741 (2000). This paper and references 63-65 were the first to show directly that pVHL polyubiquitylates HIF-α subunits.
    • (2000) J. Biol. Chem. , vol.275 , pp. 25733-25741
    • Cockman, M.1
  • 63
    • 0033776536 scopus 로고    scopus 로고
    • Ubiquitination of HIF requires direct binding to the Hippel-Lindau protein β-domain
    • Ohh, M. et al. Ubiquitination of HIF requires direct binding to the Hippel-Lindau protein β-domain. Nature Cell Biol. 2, 423-427 (2000).
    • (2000) Nature Cell Biol. , vol.2 , pp. 423-427
    • Ohh, M.1
  • 64
    • 0034641615 scopus 로고    scopus 로고
    • Activation of HIF1α ubiquitination by a reconstituted von Hippel-Lindau tumor suppressor complex
    • Kamura, T. et al. Activation of HIF1α ubiquitination by a reconstituted von Hippel-Lindau tumor suppressor complex. Proc. Natl Acad. Sci. USA 97, 10430-10435 (2000).
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 10430-10435
    • Kamura, T.1
  • 65
    • 0034663894 scopus 로고    scopus 로고
    • Mechanism of regulation of the hypoxia-inducible factor-1α by the von Hippel-Lindau tumor suppressor protein
    • Tanimoto, K., Makino, Y., Pereira, T. & Poellinger, L. Mechanism of regulation of the hypoxia-inducible factor-1α by the von Hippel-Lindau tumor suppressor protein. EMBO J. 19, 4298-4309 (2000).
    • (2000) EMBO J. , vol.19 , pp. 4298-4309
    • Tanimoto, K.1    Makino, Y.2    Pereira, T.3    Poellinger, L.4
  • 66
    • 0035917313 scopus 로고    scopus 로고
    • 2 sensing
    • 2 sensing. Science 292, 464-468 (2001). This paper and reference 67 were the first to show that the interaction of pVHL with HIF-α is regulated by oxygen-dependent prolyl hydroxylation.
    • (2001) Science , vol.292 , pp. 464-468
    • Ivan, M.1
  • 67
    • 0035917808 scopus 로고    scopus 로고
    • 2-regulated prolyl hydroxylation
    • 2-regulated prolyl hydroxylation. Science 292, 468-472 (2001).
    • (2001) Science , vol.292 , pp. 468-472
    • Jaakkola, P.1
  • 68
    • 0035859692 scopus 로고    scopus 로고
    • HIF1α binding to VHL is regulated by stimulus-sensitive proline hydroxylation
    • Yu, F., White, S., Zhao, Q. & Lee, F. HIF1α binding to VHL is regulated by stimulus-sensitive proline hydroxylation. Proc. Natl Acad. Sci. USA 98, 9630-9635 (2001).
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 9630-9635
    • Yu, F.1    White, S.2    Zhao, Q.3    Lee, F.4
  • 69
    • 0035872479 scopus 로고    scopus 로고
    • Dynamic, site-specific interaction of hypoxia-inducible factor-1α with the von Hippel-Lindau tumor suppressor protein
    • Yu, F., White, S., Zhao, Q. & Lee, F. Dynamic, site-specific interaction of hypoxia-inducible factor-1α with the von Hippel-Lindau tumor suppressor protein. Cancer Res. 61, 4136-4142 (2001).
    • (2001) Cancer Res. , vol.61 , pp. 4136-4142
    • Yu, F.1    White, S.2    Zhao, Q.3    Lee, F.4
  • 70
    • 18444368709 scopus 로고    scopus 로고
    • Structural basis for the recognition of hydroxyproline in HIF1α by pVHL
    • Hon, W. C. et al. Structural basis for the recognition of hydroxyproline in HIF1α by pVHL. Nature 417, 975-978 (2002). This paper and reference 71 report the structure of pVHL bound to HIF-1α and explain the requirement for prolyl hydroxylation.
    • (2002) Nature , vol.417 , pp. 975-978
    • Hon, W.C.1
  • 71
    • 0037035851 scopus 로고    scopus 로고
    • Structure of a pVHL-HIF1α complex: Hydroxyproline recognition in intracellular signaling
    • Min, J.-H. et al. Structure of a pVHL-HIF1α complex: hydroxyproline recognition in intracellular signaling. Science 296, 1886-1889 (2002).
    • (2002) Science , vol.296 , pp. 1886-1889
    • Min, J.-H.1
  • 72
    • 0032760945 scopus 로고    scopus 로고
    • Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes
    • Schofield, C. J. & Zhang, Z. Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes. Curr. Opin. Struct. Biol. 9, 722-731 (1999).
    • (1999) Curr. Opin. Struct. Biol. , vol.9 , pp. 722-731
    • Schofield, C.J.1    Zhang, Z.2
  • 73
    • 0031893340 scopus 로고    scopus 로고
    • Prolyl 4-hydroxylases and their protein disulfide isomerase subunit
    • Kvirikko, K. I. & Myllyharju, J. Prolyl 4-hydroxylases and their protein disulfide isomerase subunit. Matrix Biol. 16, 357-368 (1998).
    • (1998) Matrix Biol. , vol.16 , pp. 357-368
    • Kvirikko, K.I.1    Myllyharju, J.2
  • 74
    • 0035812318 scopus 로고    scopus 로고
    • Characterization and comparative analysis of the EGLN gene family
    • Taylor, M. S. Characterization and comparative analysis of the EGLN gene family. Gene 275, 125-132 (2001).
    • (2001) Gene , vol.275 , pp. 125-132
    • Taylor, M.S.1
  • 75
    • 4243396135 scopus 로고    scopus 로고
    • Biochemical purification and pharmacological inhibition of a mammalian HIF prolyl hydroxylase
    • in the press
    • Ivan, M. et al. Biochemical purification and pharmacological inhibition of a mammalian HIF prolyl hydroxylase. Proc. Natl Acad. Sci. USA (in the press).
    • Proc. Natl. Acad. Sci. USA
    • Ivan, M.1
  • 76
    • 0036469146 scopus 로고    scopus 로고
    • Transcription. Oxygen sensing gets a second wind
    • Bruick, R. & McKnight, S. Transcription. Oxygen sensing gets a second wind. Science 295, 807-808 (2002).
    • (2002) Science , vol.295 , pp. 807-808
    • Bruick, R.1    McKnight, S.2
  • 77
    • 0036469038 scopus 로고    scopus 로고
    • Asparagine hydroxylation of the HIF transactivation domain: A hypoxic switch
    • Lando, D. et al. Asparagine hydroxylation of the HIF transactivation domain: a hypoxic switch. Science 295, 858-861 (2002).
    • (2002) Science , vol.295 , pp. 858-861
    • Lando, D.1
  • 78
    • 0036232662 scopus 로고    scopus 로고
    • Carboxy-terminal transactivation activity of hypoxia-inducible factor-1α is governed by a von Hippel-Lindau protein-independent, hydroxylation-regulated association with p300/CBP
    • Sang, N., Fang, J., Srinivas, V., Leshchinsky, I. & Caro, J. Carboxy-terminal transactivation activity of hypoxia-inducible factor-1α is governed by a von Hippel-Lindau protein-independent, hydroxylation-regulated association with p300/CBP. Mol. Cell Biol. 22, 2984-2992 (2002).
    • (2002) Mol. Cell Biol. , vol.22 , pp. 2984-2992
    • Sang, N.1    Fang, J.2    Srinivas, V.3    Leshchinsky, I.4    Caro, J.5
  • 79
    • 0037117479 scopus 로고    scopus 로고
    • Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1α
    • Freedman, S. et al. Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1α. Proc. Natl Acad. Sci. USA 99, 5367-5372 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 5367-5372
    • Freedman, S.1
  • 80
    • 0037117486 scopus 로고    scopus 로고
    • From the cover: Structural basis for Hif-1α/CBP recognition in the cellular hypoxic response
    • Dames, S., Martinez-Yamout, M., De Guzman, R., Dyson, H. & Wright, P. From the cover: structural basis for Hif-1α/CBP recognition in the cellular hypoxic response. Proc. Natl Acad. Sci. USA 99, 5271-5276 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 5271-5276
    • Dames, S.1    Martinez-Yamout, M.2    De Guzman, R.3    Dyson, H.4    Wright, P.5
  • 81
    • 18544386401 scopus 로고    scopus 로고
    • Hypoxia-inducible Factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family
    • Hewitson, K. S. et al. Hypoxia-inducible Factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family. J. Biol. Chem. 277, 26351-26355 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 26351-26355
    • Hewitson, K.S.1
  • 82
    • 0034649507 scopus 로고    scopus 로고
    • Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling
    • Wykoff, C., Pugh, C., Maxwell, P., Harris A. & Ratcliffe, P. Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling. Oncogene 19, 6297-3605 (2000).
    • (2000) Oncogene , vol.19 , pp. 6297-3605
    • Wykoff, C.1    Pugh, C.2    Maxwell, P.3    Harris, A.4    Ratcliffe, P.5
  • 83
    • 0034629304 scopus 로고    scopus 로고
    • Identification of alternative spliced variants of human hypoxia-inducible factor-1α
    • Gothie, E., Richard, D., Berra, E., Pages, G. & Pouyssegur, J. Identification of alternative spliced variants of human hypoxia-inducible factor-1α. J. Biol. Chem. 275, 6922-6927 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 6922-6927
    • Gothie, E.1    Richard, D.2    Berra, E.3    Pages, G.4    Pouyssegur, J.5
  • 84
    • 0035336706 scopus 로고    scopus 로고
    • von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF
    • Hoffman, M. et al. von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF. Hum. Mol. Genet. 10, 1019-1027 (2001).
    • (2001) Hum. Mol. Genet. , vol.10 , pp. 1019-1027
    • Hoffman, M.1
  • 85
    • 0035476509 scopus 로고    scopus 로고
    • Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1α
    • Elson, D. et al. Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1α. Genes Dev. 15, 2520-2532 (2001).
    • (2001) Genes Dev. , vol.15 , pp. 2520-2532
    • Elson, D.1
  • 86
    • 0034739533 scopus 로고    scopus 로고
    • Angiogenesis is induced in a rabbit model of hindlimb ischemia by naked DNA encoding an HIF-1α/VP 16 hybrid transcription factor
    • Vincent, K. et al. Angiogenesis is induced in a rabbit model of hindlimb ischemia by naked DNA encoding an HIF-1α/VP16 hybrid transcription factor. Circulation 102, 2255-2261 (2000).
    • (2000) Circulation , vol.102 , pp. 2255-2261
    • Vincent, K.1
  • 87
    • 0033600881 scopus 로고    scopus 로고
    • Direct interaction of the β-domain of VHL tumor suppressor protein with the regulatory domain of atypical PKC isotypes
    • Okuda, H. et al. Direct interaction of the β-domain of VHL tumor suppressor protein with the regulatory domain of atypical PKC isotypes. Biochem. Biophys. Res Commun. 263, 491-497 (1999).
    • (1999) Biochem. Biophys. Res Commun. , vol.263 , pp. 491-497
    • Okuda, H.1
  • 88
    • 0035941291 scopus 로고    scopus 로고
    • The von Hippel-Lindau (VHL) tumor suppressor protein mediates ubiquitination of activated atypical protein kinase C
    • Okuda, H. et al. The von Hippel-Lindau (VHL) tumor suppressor protein mediates ubiquitination of activated atypical protein kinase C. J. Biol. Chem. 276, 43611-43617 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 43611-43617
    • Okuda, H.1
  • 89
    • 0030735367 scopus 로고    scopus 로고
    • The von Hippel-Lindau gene product inhibits vascular permeability factor/vascular endothelial growth factor expression in renal cell carcinoma by blocking protein kinase C pathways
    • Pal, S., Claffey, K., Dvorak. H. & Mukhopadhyay, D. The von Hippel-Lindau gene product inhibits vascular permeability factor/vascular endothelial growth factor expression in renal cell carcinoma by blocking protein kinase C pathways. J. Biol. Chem. 272, 27509-27512 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 27509-27512
    • Pal, S.1    Claffey K.Dvorak, H.2    Mukhopadhyay, D.3
  • 90
    • 0032500637 scopus 로고    scopus 로고
    • Activation of Sp1-mediated vascular permeability factor/vascular endothelial growth factor transcription requires specific interaction with protein kinase C
    • Pal, S., Claffey, K., Cohen, H. & Mukhopadhyay, D. Activation of Sp1-mediated vascular permeability factor/vascular endothelial growth factor transcription requires specific interaction with protein kinase C. J. Biol. Chem. 273, 26277-26280 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 26277-26280
    • Pal, S.1    Claffey, K.2    Cohen, H.3    Mukhopadhyay, D.4
  • 91
    • 17144445958 scopus 로고    scopus 로고
    • An important von Hippel-Lindau tumor suppressor domain mediates Sp1-binding and self-association
    • Cohen, H. et al. An important von Hippel-Lindau tumor suppressor domain mediates Sp1-binding and self-association. Biochem. Biophys. Res. Commun. 266, 43-50 (1999).
    • (1999) Biochem. Biophys. Res. Commun. , vol.266 , pp. 43-50
    • Cohen, H.1
  • 92
    • 0030834249 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumor suppressor gene product interacts with Sp 1 to repress vascular endothelial growth factor promoter activity
    • Mukhopadhyay, D., Knebelmann, B., Cohen, H., Ananth, S. & Sukhatme, V. The von Hippel-Lindau tumor suppressor gene product interacts with Sp1 to repress vascular endothelial growth factor promoter activity. Mol. Cell. Biol. 17, 5629-5639 (1997).
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 5629-5639
    • Mukhopadhyay, D.1    Knebelmann, B.2    Cohen, H.3    Ananth, S.4    Sukhatme, V.5
  • 93
    • 0033400674 scopus 로고    scopus 로고
    • Formation of the VHL-elongin-B/C tumor suppressor complex is mediated by the chaperonin TRiC
    • Feldman, D., Thulasiraman, V., Ferreyra, R. & Frydman, J. Formation of the VHL-elongin-B/C tumor suppressor complex is mediated by the chaperonin TRiC. Mol. Cell 4, 1051-1061 (1999).
    • (1999) Mol. Cell , vol.4 , pp. 1051-1061
    • Feldman, D.1    Thulasiraman, V.2    Ferreyra, R.3    Frydman, J.4
  • 94
    • 0036176874 scopus 로고    scopus 로고
    • Diverse effects of mutations in exon II of the von Hippel-Lindau (VHL) tumor suppressor gene on the interaction of pVHL with the cytosolic chaperonin and pVHL-dependent ubiquitin ligase activity
    • Hansen, W. et al. Diverse effects of mutations in exon II of the von Hippel-Lindau (VHL) tumor suppressor gene on the interaction of pVHL with the cytosolic chaperonin and pVHL-dependent ubiquitin ligase activity. Mol. Cell. Biol. 22, 1947-1960 (2002).
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 1947-1960
    • Hansen, W.1
  • 95
    • 0032085240 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix
    • Ohh, M. et al. The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix. Mol. Cell 1, 959-968 (1998).
    • (1998) Mol. Cell , vol.1 , pp. 959-968
    • Ohh, M.1
  • 96
    • 0032211360 scopus 로고    scopus 로고
    • von Hippel-Lindau gene-mediated growth suppression and induction of differentiation in renal cell carcinoma cells grown as multicellular tumor spheroids
    • Lieubeau-Teillet, B. et al. von Hippel-Lindau gene-mediated growth suppression and induction of differentiation in renal cell carcinoma cells grown as multicellular tumor spheroids. Cancer Res. 58, 4957-4962 (1998).
    • (1998) Cancer Res. , vol.58 , pp. 4957-4962
    • Lieubeau-Teillet, B.1
  • 97
    • 0037093099 scopus 로고    scopus 로고
    • Role of the von Hippel-Lindau tumor suppressor gene in the formation of β1-integrin fibrillar adhesions
    • Esteban-Barragan, M. et al. Role of the von Hippel-Lindau tumor suppressor gene in the formation of β1-integrin fibrillar adhesions. Cancer Res. 62, 2929-2936 (2002).
    • (2002) Cancer Res. , vol.62 , pp. 2929-2936
    • Esteban-Barragan, M.1
  • 98
    • 0035865958 scopus 로고    scopus 로고
    • Endoplasmic reticulum/cytosolic localization of von Hippel-Lindau gene products is mediated by a 64-amino acid region
    • Schoenfeld, A., Davidowitz, E. & Burk, R. Endoplasmic reticulum/cytosolic localization of von Hippel-Lindau gene products is mediated by a 64-amino acid region. Int. J. Cancer 91, 457-467 (2001).
    • (2001) Int. J. Cancer , vol.91 , pp. 457-467
    • Schoenfeld, A.1    Davidowitz, E.2    Burk, R.3
  • 99
    • 0032908982 scopus 로고    scopus 로고
    • Protective function of von Hippel-Lindau protein against impaired protein processing in renal carcinoma cells
    • Gorospe, M. et al. Protective function of von Hippel-Lindau protein against impaired protein processing in renal carcinoma cells. Mol. Cell. Biol. 19, 289-300 (1999).
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 289-300
    • Gorospe, M.1
  • 100
    • 0032795938 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cells
    • Koochekpour, S. et al. The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cells. Mol. Cell Biol. 19, 5902-5912 (1999).
    • (1999) Mol. Cell Biol. , vol.19 , pp. 5902-5912
    • Koochekpour, S.1
  • 101
    • 0030006001 scopus 로고    scopus 로고
    • Expression of growth factors and growth factor receptors in capillary hemangioblastoma
    • Bohling, T. et al. Expression of growth factors and growth factor receptors in capillary hemangioblastoma. J. Neuropathol. Exp. Neurol. 55, 522-527 (1996).
    • (1996) J. Neuropathol. Exp. Neurol. , vol.55 , pp. 522-527
    • Bohling, T.1
  • 102
    • 0031870653 scopus 로고    scopus 로고
    • Up-regulation of vascular endothelial growth factor in stromal cells of hemangioblastomas is correlated with up-regulation of the transcription factor HRF/HIF-2α
    • Flamme, I., Krieg, M. & Plate, K. Up-regulation of vascular endothelial growth factor in stromal cells of hemangioblastomas is correlated with up-regulation of the transcription factor HRF/HIF-2alpha;. Am. J. Pathol. 153, 25-29 (1998).
    • (1998) Am. J. Pathol. , vol.153 , pp. 25-29
    • Flamme, I.1    Krieg, M.2    Plate, K.3
  • 103
    • 0026717646 scopus 로고
    • Retinal hemangioblastoma. A histologic, immunohistochemical, and ultrastructural evaluation
    • Grossniklaus, H., Thomas, J., Vigneswaran, N. & Jarrett, W. H. Retinal hemangioblastoma. A histologic, immunohistochemical, and ultrastructural evaluation. Ophthalmology 99, 140-145 (1992).
    • (1992) Ophthalmology , vol.99 , pp. 140-145
    • Grossniklaus, H.1    Thomas, J.2    Vigneswaran, N.3    Jarrett, W.H.4
  • 105
    • 0029153743 scopus 로고
    • Coexpression of transforming growth factor-alpha; and epidermal growth factor receptor in capillary hemangioblastomas of the central nervous system
    • Reifenberger, G., Reifenberger, J., Bilzer, T., Wechsler, W. & Collins, V. Coexpression of transforming growth factor-alpha; and epidermal growth factor receptor in capillary hemangioblastomas of the central nervous system. Am. J. Pathol. 147, 245 (1995).
    • (1995) Am. J. Pathol. , vol.147 , pp. 245
    • Reifenberger, G.1    Reifenberger, J.2    Bilzer, T.3    Wechsler, W.4    Collins, V.5
  • 106
    • 0028929991 scopus 로고
    • Up-regulation of vascular endothelial growth factor and its receptors in von Hippel-Lindau disease-associated and sporadic hemangioblastomas
    • Wizigmann-Voos, S., Breier, G., Risau, W. & Plate, K. Up-regulation of vascular endothelial growth factor and its receptors in von Hippel-Lindau disease-associated and sporadic hemangioblastomas. Cancer Res. 55, 1358-1364 (1995).
    • (1995) Cancer Res. , vol.55 , pp. 1358-1364
    • Wizigmann-Voos, S.1    Breier, G.2    Risau, W.3    Plate, K.4
  • 107
    • 0032916281 scopus 로고    scopus 로고
    • VHL gene deletion and enhanced VEGF-gene expression detected in the stromal cells of retinal angioma
    • Chan, C. et al. VHL gene deletion and enhanced VEGF-gene expression detected in the stromal cells of retinal angioma. Arch. Ophthalmol. 117, 625-630 (1999).
    • (1999) Arch. Ophthalmol. , vol.117 , pp. 625-630
    • Chan, C.1
  • 108
    • 0031964099 scopus 로고    scopus 로고
    • Transforming growth factor-α is a target for the von Hippel-Lindau tumor suppressor
    • Knebelmann, B., Ananth, S., Cohen, H. & Sukhatme, V. Transforming growth factor-α is a target for the von Hippel-Lindau tumor suppressor. Cancer Res. 58, 226-231 (1998).
    • (1998) Cancer Res. , vol.58 , pp. 226-231
    • Knebelmann, B.1    Ananth, S.2    Cohen, H.3    Sukhatme, V.4
  • 109
    • 0142237260 scopus 로고    scopus 로고
    • Reference deleted in proof
    • Reference deleted in proof.
  • 110
    • 0030806273 scopus 로고    scopus 로고
    • Conditional switching of vascular endothelial growth factor (VEGF) expression in tumors: Induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal
    • Benjamin, L. E. & Keshet, E. Conditional switching of vascular endothelial growth factor (VEGF) expression in tumors: induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal. Proc. Natl Acad. Sci. USA 94, 8761-8766 (1997).
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 8761-8766
    • Benjamin, L.E.1    Keshet, E.2
  • 111
    • 0037090776 scopus 로고    scopus 로고
    • Conditional switching of VEGF provides new insights into adult neovascularization and pro-angiogenic therapy
    • Dor, Y. et al. Conditional switching of VEGF provides new insights into adult neovascularization and pro-angiogenic therapy. EMBO J. 21, 1939-1947 (2002).
    • (2002) EMBO J. , vol.21 , pp. 1939-1947
    • Dor, Y.1
  • 112
    • 0029155806 scopus 로고
    • Exogenous vascular endothelial growth factor induces malformed and hyperfused vessels during embryonic neovascularization
    • Drake, C. & Little, C. Exogenous vascular endothelial growth factor induces malformed and hyperfused vessels during embryonic neovascularization. Proc. Natl Acad. Sci. USA 92, 7657-7661 (1995).
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 7657-7661
    • Drake, C.1    Little, C.2
  • 113
    • 0035852668 scopus 로고    scopus 로고
    • Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor
    • Haase, V., Glickman, J., Socolovsky, M. & Jaenisch, R. Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor. Proc. Natl Acad. Sci. USA 98, 1583-1588 (2001).
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 1583-1588
    • Haase, V.1    Glickman, J.2    Socolovsky, M.3    Jaenisch, R.4
  • 114
    • 0025975990 scopus 로고
    • Allelotype of renal cell carcinoma
    • Monta, R. et al. Allelotype of renal cell carcinoma. Cancer Res. 51, 820-823 (1991).
    • (1991) Cancer Res. , vol.51 , pp. 820-823
    • Monta, R.1
  • 115
    • 0028930201 scopus 로고
    • Comprehensive allelotyping of human renal cell carcinomas using microsatellite DNA probes
    • Thrash-Bingham, C. A. et al. Comprehensive allelotyping of human renal cell carcinomas using microsatellite DNA probes. Proc. Natl Acad. Sci. USA 92, 2854-2858 (1995).
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 2854-2858
    • Thrash-Bingham, C.A.1
  • 116
    • 0026329715 scopus 로고
    • Common regions of deletion on chromosomes 5q, 6q, and 10q in renal cell carcinoma
    • Morita, R. et al. Common regions of deletion on chromosomes 5q, 6q, and 10q in renal cell carcinoma. Cancer Res. 51, 5817-5820 (1991).
    • (1991) Cancer Res. , vol.51 , pp. 5817-5820
    • Morita, R.1
  • 117
    • 0028091126 scopus 로고
    • Molecular genetic investigation of sporadic renal cell carcinoma: Analysis of allele loss on chromosomes 3p, 5q, 11p, 17 and 22
    • Foster, K. et al Molecular genetic investigation of sporadic renal cell carcinoma: analysis of allele loss on chromosomes 3p, 5q, 11p, 17 and 22. Br. J. Cancer 69, 230-234 (1994).
    • (1994) Br. J. Cancer , vol.69 , pp. 230-234
    • Foster, K.1
  • 118
    • 0030936295 scopus 로고    scopus 로고
    • Duplication of an approximately 1.5 Mb DNA segment at chromosome 5q22 indicates the locus of a new tumour gene in nonpapillary renal cell carcinomas
    • Kenok, C., Bugert, P., Wilhelm, M. & Kovacs, G. Duplication of an approximately 1.5 Mb DNA segment at chromosome 5q22 indicates the locus of a new tumour gene in nonpapillary renal cell carcinomas. Oncogene 14, 1093-1098 (1997).
    • (1997) Oncogene , vol.14 , pp. 1093-1098
    • Kenok, C.1    Bugert, P.2    Wilhelm, M.3    Kovacs, G.4
  • 119
    • 0032477788 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal
    • Pause, A., Lee, S., Lonergan, K. M. & Klausner, R. D. The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal. Proc. Natl Acad. Sci. USA 95, 993-998 (1998).
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 993-998
    • Pause, A.1    Lee, S.2    Lonergan, K.M.3    Klausner, R.D.4
  • 120
    • 0035136533 scopus 로고    scopus 로고
    • VHL induces renal cell differentiation and growth arrest through integration of cell-cell and cell-extracellular-matrix signaling
    • Davidowitz, E., Schoenfeld, A. & Burk, R. VHL induces renal cell differentiation and growth arrest through integration of cell-cell and cell-extracellular-matrix signaling. Mol. Cell. Biol 21. 865-874 (2001).
    • (2001) Mol. Cell. Biol , vol.21 , pp. 865-874
    • Davidowitz, E.1    Schoenfeld, A.2    Burk, R.3
  • 121
    • 0028805059 scopus 로고
    • Suppression of growth of renal carcinoma cells by the von Hippel-Lindau tumor suppressor gene
    • Chen, F. et al. Suppression of growth of renal carcinoma cells by the von Hippel-Lindau tumor suppressor gene. Cancer Res. 55, 4804-4807 (1995).
    • (1995) Cancer Res. , vol.55 , pp. 4804-4807
    • Chen, F.1
  • 122
    • 0036528246 scopus 로고    scopus 로고
    • Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein
    • Kondo, K., Klco, J., Nakamura, E. & Kaelin, W. G. Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein. Cancer Cell 1, 237-246 (2002).
    • (2002) Cancer Cell , vol.1 , pp. 237-246
    • Kondo, K.1    Klco, J.2    Nakamura, E.3    Kaelin, W.G.4
  • 123
    • 0036527785 scopus 로고    scopus 로고
    • The contribution of VHL substrate binding and HIF1alpha; to the phenotype of VHL Loss in renal cell carcinoma
    • Maranchie, J. K. et al. The contribution of VHL substrate binding and HIF1alpha; to the phenotype of VHL Loss in renal cell carcinoma. Cancer Cell 1, 247-255 (2002).
    • (2002) Cancer Cell , vol.1 , pp. 247-255
    • Maranchie, J.K.1
  • 124
    • 0035852630 scopus 로고    scopus 로고
    • -/- clear cell renal carcinoma cell proliferation: A possible mechanism coupling von Hippel-Lindau tumor suppressor inactivation and tumorigenesis
    • -/- clear cell renal carcinoma cell proliferation: a possible mechanism coupling von Hippel-Lindau tumor suppressor inactivation and tumorigenesis. Proc. Natl Acad. Sci. USA 13, 1387-1392 (2001).
    • (2001) Proc. Natl. Acad. Sci. USA , vol.13 , pp. 1387-1392
    • De Paulsen, N.1
  • 125
    • 0024328825 scopus 로고
    • Expression of transforming growth factor-alpha; and epidermal growth factor receptor messenger RNA in neoplastic and nonneoplastic human kidney tissue
    • Mydlo, J. et al. Expression of transforming growth factor-alpha; and epidermal growth factor receptor messenger RNA in neoplastic and nonneoplastic human kidney tissue. Cancer Res. 49, 3407-3411 (1989).
    • (1989) Cancer Res. , vol.49 , pp. 3407-3411
    • Mydlo, J.1
  • 126
    • 0028452099 scopus 로고
    • The expression of epidermal growth factor receptor and transforming growth factor-alpha; in renal cell carcinoma
    • Lager, D., Slagel, D. & Palechek, P. The expression of epidermal growth factor receptor and transforming growth factor-alpha in renal cell carcinoma. Modern Pathol. 7, 544-548 (1994).
    • (1994) Modern Pathol. , vol.7 , pp. 544-548
    • Lager, D.1    Slagel, D.2    Palechek, P.3
  • 127
    • 0028501443 scopus 로고
    • Renal cysts in transgenic mice expressing transforming growth factor-alpha;
    • Lowden, D. et al. Renal cysts in transgenic mice expressing transforming growth factor-alpha;. J. Lab. Clin. Med. 124, 386-394 (1994).
    • (1994) J. Lab. Clin. Med. , vol.124 , pp. 386-394
    • Lowden, D.1
  • 128
    • 10144242640 scopus 로고    scopus 로고
    • Extensive mutation scanning of RET in sporadic medullary thyroid carcinoma and of RET and VHL in sporadic pheochromocytoma reveals involvement of these genes in only a minority of cases
    • Hofstra, R. M. W. et al. Extensive mutation scanning of RET in sporadic medullary thyroid carcinoma and of RET and VHL in sporadic pheochromocytoma reveals involvement of these genes in only a minority of cases. J. Clin. Endocrinol. Metab. 81, 2881-2884 (1996).
    • (1996) J. Clin. Endocrinol. Metab. , vol.81 , pp. 2881-2884
    • Hofstra, R.M.W.1
  • 129
    • 0032213236 scopus 로고    scopus 로고
    • The hypoxia-responsive transcription factor EPAS 1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development
    • Tian, H., Hammer, R., Matsumoto, A., Russell, D. & McKnight, S. The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development. Genes Dev. 12, 3320-3324 (1998).
    • (1998) Genes Dev. , vol.12 , pp. 3320-3324
    • Tian, H.1    Hammer, R.2    Matsumoto, A.3    Russell, D.4    McKnight, S.5
  • 130
    • 0033570052 scopus 로고    scopus 로고
    • von Hippel-Lindau protein induces hypoxia- regulated arrest of tyrosine hydroxylase transcript elongation in pheochromocytoma cells
    • Kroll, S. et al. von Hippel-Lindau protein induces hypoxia- regulated arrest of tyrosine hydroxylase transcript elongation in pheochromocytoma cells. J. Biol. Chem. 274, 30109-30114 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 30109-30114
    • Kroll, S.1
  • 131
    • 0037086279 scopus 로고    scopus 로고
    • Endogenous von Hippel-Lindau tumor suppressor protein regulates catecholaminergic phenotype in PC 12 cells
    • Bauer, A., Paulding, W., Striet, J., Schnell, P. & Czyzyk- Krzeska, M. Endogenous von Hippel-Lindau tumor suppressor protein regulates catecholaminergic phenotype in PC12 cells. Cancer Res. 62, 1682-1687 (2002).
    • (2002) Cancer Res. , vol.62 , pp. 1682-1687
    • Bauer, A.1    Paulding, W.2    Striet, J.3    Schnell, P.4    Czyzyk-Krzeska, M.5
  • 132
    • 0029949784 scopus 로고    scopus 로고
    • E2F- 1 functions in mice to promote apoptosis and suppress proliferation
    • Field, S. J. et al. E2F-1 functions in mice to promote apoptosis and suppress proliferation. Cell 85, 549-561 (1996).
    • (1996) Cell , vol.85 , pp. 549-561
    • Field, S.J.1
  • 133
    • 0032100732 scopus 로고    scopus 로고
    • HIF-1alpha; is required for solid tumor formation and embryonic vascularization
    • Ryan, H., Lo, J. & Johnson, R. HIF-1apha; is required for solid tumor formation and embryonic vascularization. EMBO J. 17, 3005-3015 (1998).
    • (1998) EMBO J. , vol.17 , pp. 3005-3015
    • Ryan, H.1    Lo, J.2    Johnson, R.3
  • 134
    • 0033870727 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1alpha; is a positive factor in solid tumor growth
    • Ryan, H. et al. Hypoxia-inducible factor-1alpha; is a positive factor in solid tumor growth. Cancer Res. 60, 4010-4015 (2000).
    • (2000) Cancer Res. , vol.60 , pp. 4010-4015
    • Ryan, H.1
  • 135
    • 0030816109 scopus 로고    scopus 로고
    • Hypoxia-inducible factor- 1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth
    • Maxwell, P. et al. Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth. Proc. Natl Acad. Sci. USA 94, 8104-8109 (1997).
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 8104-8109
    • Maxwell, P.1
  • 136
    • 0033454716 scopus 로고    scopus 로고
    • Anticancer drug targets: Approaching angiogenesis
    • Keshet, E. & Ben-Sasson, S. Anticancer drug targets: approaching angiogenesis. J. Clin. Invest. 104, 1497-1501 (1999).
    • (1999) J. Clin. Invest. , vol.104 , pp. 1497-1501
    • Keshet, E.1    Ben-Sasson, S.2
  • 137
    • 0034677755 scopus 로고    scopus 로고
    • Mechanism-based target identification and drug discovery in cancer research
    • Gibbs, J. Mechanism-based target identification and drug discovery in cancer research. Science 287, 1969 (2000).
    • (2000) Science , vol.287 , pp. 1969
    • Gibbs, J.1
  • 138
    • 0034282515 scopus 로고    scopus 로고
    • Effects of PTK787/ZK 222584, a specific inhibitor of vascular endothelial growth factor receptor tyrosine kinases, on primary tumor, metastasis, vessel density, and blood flow in a murine renal cell carcinoma model
    • Drevs, J. et al. Effects of PTK787/ZK 222584, a specific inhibitor of vascular endothelial growth factor receptor tyrosine kinases, on primary tumor, metastasis, vessel density, and blood flow in a murine renal cell carcinoma model. Cancer Res. 60, 4819-4824 (2000).
    • (2000) Cancer Res. , vol.60 , pp. 4819-4824
    • Drevs, J.1
  • 139
    • 0032407024 scopus 로고    scopus 로고
    • Mouse-human chimeric anti-epidermal growth factor receptor antibody C 225 inhibits the growth of human renal cell carcinoma xenografts in nude mice
    • Prewett, M., Rothman, M., Feldman, M., Bander, N. & Hicklin, D. Mouse-human chimeric anti-epidermal growth factor receptor antibody C225 inhibits the growth of human renal cell carcinoma xenografts in nude mice. Clin. Cancer Res. 4, 2957-2966 (1998).
    • (1998) Clin. Cancer Res. , vol.4 , pp. 2957-2966
    • Prewett, M.1    Rothman, M.2    Feldman, M.3    Bander, N.4    Hicklin, D.5
  • 140
    • 0032527802 scopus 로고    scopus 로고
    • Cooperative inhibition of renal cancer growth by anti-epidermal growth factor receptor antibody and protein kinase A antisense oligonucleotide
    • Ciardiello, F. et al. Cooperative inhibition of renal cancer growth by anti-epidermal growth factor receptor antibody and protein kinase A antisense oligonucleotide. J. Natl. Cancer Int. 90, 1087-1094 (1998).
    • (1998) J. Natl. Cancer Int. , vol.90 , pp. 1087-1094
    • Ciardiello, F.1
  • 141
    • 0033995015 scopus 로고    scopus 로고
    • Treatment of polycystic kidney disease with a novel tyrosine kinase inhibitor
    • Sweeney, W., Chen, Y., Nakanishi, K., Frost, P. & Avner, E. Treatment of polycystic kidney disease with a novel tyrosine kinase inhibitor. Kidney Int. 57, 33-40 (2000).
    • (2000) Kidney Int. , vol.57 , pp. 33-40
    • Sweeney, W.1    Chen, Y.2    Nakanishi, K.3    Frost, P.4    Avner, E.5
  • 142
    • 0142237259 scopus 로고    scopus 로고
    • Rapid and durable recovery of visual function in a patient with von Hippel-Lindau syndrome and optic nerve head hemangioma following systemic treatment with the VEGF receptor inhibitor SU5416
    • in the press
    • Aiello, L. et al. Rapid and durable recovery of visual function in a patient with von Hippel-Lindau syndrome and optic nerve head hemangioma following systemic treatment with the VEGF receptor inhibitor SU5416. Ophthalmology (in the press).
    • Ophthalmology
    • Aiello, L.1
  • 143
    • 0037092958 scopus 로고    scopus 로고
    • Paradoxical secondary polycythemia in von Hippel-Lindau patients treated with anti-vascular endothelial growth factor receptor therapy
    • Richard, S. et al. Paradoxical secondary polycythemia in von Hippel-Lindau patients treated with anti-vascular endothelial growth factor receptor therapy. Blood 99, 3851-3853 (2002).
    • (2002) Blood , vol.99 , pp. 3851-3853
    • Richard, S.1
  • 144
    • 0036667385 scopus 로고    scopus 로고
    • Protein tyrosine kinase inhibitors: New treatment modalities?
    • Fabbro, D., Parkinson, D. & Matter, A. Protein tyrosine kinase inhibitors: new treatment modalities? Curr. Opin. Pharmacol. 2, 374-381 (2002).
    • (2002) Curr. Opin. Pharmacol. , vol.2 , pp. 374-381
    • Fabbro, D.1    Parkinson, D.2    Matter, A.3
  • 145
    • 0035975982 scopus 로고    scopus 로고
    • Inhibition of collagen synthesis with prolyl 4-hydroxylase inhibitor improves left ventricular function and alters the pattern of left ventricular dilation after myocardial infarction
    • Nwogu, J. I. et al. Inhibition of collagen synthesis with prolyl 4-hydroxylase inhibitor improves left ventricular function and alters the pattern of left ventricular dilation after myocardial infarction. Circulation 104, 2216-2221 (2001).
    • (2001) Circulation , vol.104 , pp. 2216-2221
    • Nwogu, J.I.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.