Increased radiosensitivity and radiothermosensitivity of human pancreatic MIA PaCa-2 and U251 glioblastoma cell lines treated with the novel Hsp90 inhibitor NVP-HSP990

Radiation Oncology

Volumn 8, Issue 1, 2013, Pages

  Milanović, Dušan ^a   Firat, Elke ^a   Grosu, Anca Ligia ^a   Niedermann, Gabriele ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

NVP HSP990; Radiosensitivity; Radiothermosensitivity

Indexed keywords

HEAT SHOCK PROTEIN 90 INHIBITOR; NVP HSP 990; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER SURVIVAL; CELL COUNT; CELL CYCLE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL DEATH; CELL PROLIFERATION; CELL VIABILITY; CLONOGENESIS; FLOW CYTOMETRY; GLIOBLASTOMA; HUMAN; HUMAN CELL; HYPERTHERMIA; IMMUNOHISTOCHEMISTRY; MITOSIS; NECROSIS; RADIATION DOSE; RADIOSENSITIVITY; RADIOTHERMOSENSITIVITY;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BRAIN NEOPLASMS; CELL CYCLE; CELL PROLIFERATION; COLONY-FORMING UNITS ASSAY; COMBINED MODALITY THERAPY; FLOW CYTOMETRY; GAMMA RAYS; GLIOBLASTOMA; HSP90 HEAT-SHOCK PROTEINS; HUMANS; HYPERTHERMIA, INDUCED; PYRIDONES; PYRIMIDINES; RADIATION TOLERANCE; RADIATION-SENSITIZING AGENTS; TUMOR CELLS, CULTURED;

EID: 84874377917     PISSN: None     EISSN: 1748717X     Source Type: Journal    
DOI: 10.1186/1748-717X-8-42     Document Type: Article

References (36)

1. Wandinger SK, Richter K, Buchner J. The Hsp90 chaperone machinery. J Biol Chem 2008, 283:18473-18477. 10.1074/jbc.R800007200, 18442971.
2. Gooljarsingh LT, Fernandes C, Yan K. A biochemical rationale for the anticancer effects of Hsp90 inhibitors: slow, tight binding inhibition by geldanamycin and its analogues. Proc Natl Acad Sci U S A 2006, 103:7625-7630. 10.1073/pnas.0602650103, 1458618, 16684877.
3. Trepel J, Mollapour M, Giaccone G, Neckers L. Targeting the dynamic HSP90 complex in cancer. Nat Rev Cancer 2010, 10:537-549.
4. Chautard E, Loubeau G, Tchirkov A, Chassagne J, Vermot-Desroches C, Morel L, Verrelle P. Akt signaling pathway: a target for radiosensitizing human malignant glioma. Neuro Oncol 2010, 12:434-443. 2940626, 20406894.
5. Pietras RJ, Poen JC, Gallardo D, Wongvipat PN, Lee HJ, Slamon DJ. Monoclonal antibody to HER-2/neureceptor modulates repair of radiation-induced DNA damage and enhances radiosensitivity of human breast cancer cells overexpressing this oncogene. Cancer Res 1999, 59:1347-1355.
6. Pirollo KF, Hao Z, Rait A, Ho CW, Chang EH. Evidence supporting a signal transduction pathway leading to the radiation-resistant phenotype in human tumor cells. Biochem Biophys Res Commun 1997, 230:196-201. 10.1006/bbrc.1996.5922, 9020045.
7. Kampinga HH, Dikomey E. Hyperthermic radiosensitization: mode of action and clinical relevance. Int J Radiat Biol 2001, 77:399-408. 10.1080/09553000010024687, 11304434.
8. Frey B, Weiss EM, Rubner Y. Old and new facts about hyperthermia-induced modulations of the immune system. Int J Hyperthermia 2012, 28:528-542. 10.3109/02656736.2012.677933, 22690925.
9. Horsman MR, Overgaard J. Hyperthermia: a potent enhancer of radiotherapy. Clin Oncol 2007, 19:418-426.
10. Ciocca DR, Fuqua SA, Lock-Lim S, Toft DO, Welch WJ, McGuire WL. Response of human breast cancer cells to heat shock and chemotherapeutic drugs. Cancer Res 1992, 52:3648-3654.
11. Massey AJ, Schoepfer J, Brough PA, Brueggen J. Preclinical antitumor activity of the orally available heat shock protein 90 inhibitor NVP-BEP800. Mol Cancer Ther 2010, 9:906-919. 10.1158/1535-7163.MCT-10-0055, 20371713.
12. Stingl L, Stühmer T, Chatterjee M, Jensen MR, Flentje M, Djuzenova CS. Novel HSP90 inhibitors, NVP-AUY922 and NVP-BEP800, radiosensitise tumour cells through cell-cycle impairment, increased DNA damage and repair protraction. Br J Cancer 2010, 25:1578-1591.
13. Stupp R, Mason WP, van den Bent MJ. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 2005, 352:987-996. 10.1056/NEJMoa043330, 15758009.
14. Conroy T, Desseigne F, Ychou M. FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. N Engl J Med 2011, 364:1817-1825. 10.1056/NEJMoa1011923, 21561347.
15. Effect of more than one inhibitor; enzyme and metabolic inhibitors. Vol. 1 1963, 466-487. Academic Press: New York, Webb JL.
16. Li GC, Kal HB. Effect of hyperthermia on the radiation response of two mammalian cell lines. Eur J Cancer 1977, 13:65-69.
17. Krawczyk PM, Eppink B, Essers J. Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition. Proc Natl Acad Sci U S A 2011, 108:9851-9856. 10.1073/pnas.1101053108, 3116433, 21555554.
18. Bergs JW, Franken NA, Haveman J. Hyperthermia, cisplatin and radiation trimodality treatment: a promising cancer treatment? A review from preclinical studies to clinical application. Int J Hyperthermia 2007, 23:329-341. 10.1080/02656730701378684, 17558732.
19. Wendtner CM, Abdel-Rahman S, Krych M. Response to neoadjuvant chemotherapy combined with regional hyperthermia predicts long-term survival for adult patients with retroperitoneal and visceral high-risk soft tissue sarcomas. J Clin Oncol 2002, 20(14):3156-3164. 10.1200/JCO.2002.07.146, 12118030.
20. Lutgens L, van der Zee J, Pijls-Johannesma M. Combined use of hyperthermia and radiation therapy for treating locally advanced cervical carcinoma. Cochrane Database Syst Rev 2010, 1:CD006377.
21. Overgaard J, Gonzalez Gonzalez D, Hulshof MC. Randomised trial of hyperthermia as adjuvant to radiotherapy for recurrent or metastatic malignant melanoma. European Society for Hyperthermic Oncology. Lancet 1995, 345:540-543. 10.1016/S0140-6736(95)90463-8, 7776772.
22. Kampinga HH. Cell biological effects of hyperthermia alone or combined with radiation or drugs: a short introduction to newcomers in the field. Int J Hyperthermia 2006, 22:191-196. 10.1080/02656730500532028, 16754338.
23. Calderwood SK, Ciocca DR. Heat shock proteins: stress proteins with Janus-like properties in cancer. Int J Hyperthermia 2008, 24:31-39. 10.1080/02656730701858305, 18214767.
24. Madlener S, Rosner M, Krieger S. Short 42 degrees C heat shock induces phosphorylation and degradation of Cdc25A which depends on p38MAPK, Chk2 and 14.3.3. Hum Mol Genet 2009, 18:1990-2000. 10.1093/hmg/ddp123, 19289404.
25. Xiao Z, Chen Z, Gunasekera AH. Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents. J Biol Chem 2003, 278:21767-21773. 10.1074/jbc.M300229200, 12676925.
26. Hahn GM. Hyperthermia and cancer 1982, New York: Plenum Press.
27. Sapareto SA, Raaphorst GP, Dewey WC. Cell killing and the sequencing of hyperthermia and radiation. Int J Radiat Oncol Biol Phys 1979, 5:343-347. 10.1016/0360-3016(79)91214-8, 457480.
28. Bisht KS, Bradbury CM, Mattson D. Geldanamycin and 17-allylamino-17-demethoxygeldanamycin potentiate the in vitro and in vivo radiation response of cervical tumor cells via the heat shock protein 90-mediated intracellular signaling and cytotoxicity. Cancer Res 2003, 63(24):8984-8995.
29. Machida H, Matsumoto Y, Shirai M, Kubota N. Geldanamycin, an inhibitor of Hsp90, sensitizes human tumour cells to radiation. Int J Radiat Biol 2003, 79:973-980. 10.1080/09553000310001626135, 14713575.
30. Dote H, Burgan WE, Camphausen K, Tofilon PJ. Inhibition of hsp90 compromises the DNA damage response to radiation. Cancer Res 2006, 66:9211-9220. 10.1158/0008-5472.CAN-06-2181, 16982765.
31. Bull EE, Dote H, Brady KJ. Enhanced tumor cell radiosensitivity and abrogation of G2 and S phase arrest by the Hsp90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin. Clin Cancer Res 2004, 10:8077-8084. 10.1158/1078-0432.CCR-04-1212, 15585643.
32. Sakurai H, Kitamoto Y, Saitoh J. Attenuation of chronic thermotolerance by KNK437, a benzylidene lactam compound, enhances thermal radiosensitization in mild temperature hyperthermia combined with low dose-rate irradiation. Int J Radiat Biol 2005, 81:711-718. 10.1080/09553000500448172, 16368649.
33. Ohnishi K, Yokota S, Takahashi A, Ohnishi T. Induction of radiation resistance by a heat shock protein inhibitor, KNK437, in human glioblastoma cells. Int J Radiat Biol 2006, 82(8):569-575. 10.1080/09553000600876645, 16966184.
34. Vitale I, Galluzzi L, Castedo M, Kroemer G. Mitotic catastrophe: a mechanism for avoiding genomic instability. Nat Rev Mol Cell Biol 2011, 12:385-392.
35. Galluzzi L, Vitale I, Abrams JM. Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ 2012, 19:107-120. 10.1038/cdd.2011.96, 3252826, 21760595.
36. Sekhar KR, Sonar VN, Muthusamy V. Novel chemical enhancers of heat shock increase thermal radiosensitization through a mitotic catastrophe pathway. Cancer Res 2007, 67(2):695-701. 10.1158/0008-5472.CAN-06-3212, 17234780.