c-Met signaling induces a reprogramming network and supports the glioblastoma stem-like phenotype

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 24, 2011, Pages 9951-9956

  Li, Yunqing ^a,b   Li, Angela ^a   Glas, Martin ^c   Lal, Bachchu ^a,b   Ying, Mingyao ^a,b   Sang, Yingying ^a   Xia, Shuli ^a,b   Trageser, Daniel ^c   Guerrero Cázares, Hugo ^b   Eberhart, Charles G ^b   Quiñones Hinojosa, Alfredo ^b   Scheffler, Bjorn ^c   Laterra, John ^a,b  

^a KENNEDY KRIEGER INSTITUTE   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY HOSPITAL BONN   (Germany)

Author keywords

Cancer stem cell; Hepatocyte growth factor; Klf4; Oct4; Sox2

Indexed keywords

ALDEHYDE DEHYDROGENASE; CD133 ANTIGEN; CELL SURFACE MARKER; CRIZOTINIB; FIBROBLAST GROWTH FACTOR; KRUPPEL LIKE FACTOR 4; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MYC PROTEIN; N (3 CHLOROPHENYL) 3 [3,5 DIMETHYL 4 (4 METHYL 1 PIPERAZINYLCARBONYL) 1H PYRROL 2 YLMETHYLENE] 2,3 DIHYDRO N METHYL 2 OXO 1H INDOLE 5 SULFONAMIDE; NESTIN; OCTAMER TRANSCRIPTION FACTOR 4; PROTEIN KINASE B; SCATTER FACTOR; SCATTER FACTOR RECEPTOR; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; STAGE SPECIFIC EMBRYO ANTIGEN 1; STAT3 PROTEIN; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CANCER STEM CELL; CARCINOGENESIS; CELL DIFFERENTIATION; CELL RENEWAL; CELL STRUCTURE; CONTROLLED STUDY; CORRELATION ANALYSIS; FLOW CYTOMETRY; GENE EXPRESSION; GENETIC TRANSFECTION; GLIOBLASTOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; MOUSE; NEUROSPHERE; NONHUMAN; NUCLEAR REPROGRAMMING; PHARMACOLOGICAL BLOCKING; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT;

ANIMALS; ANTIGENS, CD; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOBLASTOMA; GLYCOPROTEINS; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOBLOTTING; INDOLES; MICE; MICE, SCID; NEOPLASMS, EXPERIMENTAL; NEOPLASTIC STEM CELLS; NUCLEAR REPROGRAMMING; OCTAMER TRANSCRIPTION FACTOR-3; PEPTIDES; PHENOTYPE; PIPERAZINES; PROTO-ONCOGENE PROTEINS C-MET; PROTO-ONCOGENE PROTEINS C-MYC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SOXB1 TRANSCRIPTION FACTORS; SULFONAMIDES; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

IPS;

EID: 79959971880     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1016912108     Document Type: Article

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