Loss of PTEN facilitates HIF-1-mediated gene expression

Genes and Development

Volumn 14, Issue 4, 2000, Pages 391-396

  Zundel, Wayne ^a   Schindler, Cornelia ^a   Haas Kogan, Daphne ^b   Koong, Albert ^a   Kaper, Fiona ^a   Chen, Eunice ^a   Gottschalk, Alexander R ^b   Ryan, Heather E ^c   Johnson, Randall S ^c   Jefferson, Anne B ^d   Stokoe, David ^b   Giaccia, Amato J ^a  

^a STANFORD UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Angiogenesis; Gene expression; Glioblastoma; PTEN

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1; PHOSPHATASE; PROTEIN SERINE THREONINE KINASE; SOMATOMEDIN C; VASCULOTROPIN;

ANGIOGENESIS; APOPTOSIS; ARTICLE; CELL HYPOXIA; CONTROLLED STUDY; DNA SYNTHESIS INHIBITION; GENE EXPRESSION REGULATION; GENE LOSS; GLIOBLASTOMA; HUMAN; HUMAN CELL; PRIORITY JOURNAL; TUMOR CELL LINE; TUMOR GROWTH; TUMOR SUPPRESSOR GENE;

APOPTOSIS; BRAIN NEOPLASMS; CELL HYPOXIA; CULTURE MEDIA, SERUM-FREE; CYCLOOXYGENASE 1; DISEASE PROGRESSION; DNA-BINDING PROTEINS; ENDOTHELIAL GROWTH FACTORS; GENE DELETION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC COMPLEMENTATION TEST; GLIOBLASTOMA; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INSULIN-LIKE GROWTH FACTOR I; ISOENZYMES; LYMPHOKINES; MEMBRANE PROTEINS; NEOPLASM PROTEINS; NUCLEAR PROTEINS; PHOSPHOFRUCTOKINASE-1; PHOSPHORIC MONOESTER HYDROLASES; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RECOMBINANT FUSION PROTEINS; TRANSCRIPTION FACTORS; TRANSFECTION; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EUKARYOTA; MAMMALIA;

EID: 0034050050     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Aoki, M., O. Batista, A. Bellacosa, P. Tsichlis, and P.K. Vogt. 1998. The akt kinase: Molecular determinants of oncogenicity. Proc. Natl. Acad. Sci. 95: 14950-14955.
2. Brunei, A., A. Bonni, M.J. Zigmond, M.Z. Lin, P. Juo, L.S. Hu, M.J. Anderson, K.C. Arden, J. Blenis, and M.E. Greenberg. 1999. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96: 857-868.
3. Campbell, S.L., R. Khosravi-Far, K.L. Rossman, G.J. Clark, and C.J. Der. 1998. Increasing complexity of Ras signaling. Oncogene 17: 1395-1413.
4. Cantley, L.C. and B.C. Neel. 1999. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc. Natl. Acad. Sci. 96: 4240-4245.
5. Datta, S.R., H. Dudek, X. Tao, S. Masters, H. Fu, Y. Gotoh, and M.E. Greenberg. 1997. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91: 231-241.
6. Davies, M.A., D. Koul, H. Dhesi, R. Berman, T.J. McDonnell, D. McConkey, W.K. Yung, and P.A. Steck. 1998. Adenoviral transgene expression of MMAC/PTEN in human glioma cells inhibits Akt activation and induces anoikis. Cancer Res. 58: 5285-5290.
7. Di Cristofano, A., B. Pesce, C. Cordon-Cardo, and P.P. Pandolfi. 1998. Pten is essential for embryonic development and tumour suppression. Nat. Genet. 19: 348-355.
8. Diehl, J.A., M. Cheng, M.F. Roussel, and C.J. Sherr. 1998. Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization. Genes & Dev. 12: 3499-3511.
9. Fruman, D.A., R.E. Meyers, and L.C. Cantley. 1998. Phosphoinositide kinases. Annu. Rev. Biochem. 67: 481-507.
10. Giaccia, A.J. and M.B. Kastan. 1998. The complexity of p53 modulation: Emerging patterns from divergent signals. Genes & Dev. 12: 2973-2983.
11. Graeber, T.G., C. Osmanian, T. Jacks, D.E. Housman, C.J. Koch, S.W. Lowe, and A.J. Giaccia. 1996. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature 379: 88-91.
12. Haas-Kogan, D., N. Shalev, M. Wong, G. Mills, G. Yount, and D. Stokoe. 1998. Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC. Curr. Biol. 8: 1195-1198.
13. Hu, Q., A. Klippel, A.J. Muslin, W.J. Fantl, and L.T. Williams. 1995. Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase. Science 268: 100-102.
14. Iwai, K., K. Yamanaka, T. Kamura, N. Minato, R.C. Conaway, J.W. Conaway, R.D. Klausner, and A. Pause. 1999. Identification of the von Hippel-Lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex. Proc. Natl. Acad. Sci. 96: 12436-12441.
15. Khwaja, A., P. Rodriguez-Viciana, S. Wennstrom, P.H. Warne, and J. Downward. 1997. Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway. EMBO J. 16: 2783-2793.
16. Kohn, A.D., F. Takeuchi, and R.A. Roth. 1996. Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylation. J. Biol. Chem. 271: 21920-21926.
17. Kohn, A.D., A. Barthel, K.S. Kovacina, A. Boge, B. Wallach, S.A. Summers, M.J. Birnbaum, P.H. Scott, J.C. Lawrence Jr, and R.A. Roth. 1998. Construction and characterization of a conditionally active version of the serine/threonine kinase Akt. J. Biol. Chem. 273: 11937-11943.
18. Kops, G.J.P.L., N.D. de Ruiter, A.M. De Viries-Smits, D.R. Powell, J.L. Bos, and B.M. Burgering. 1999. Direct control of the Forkhead transcription factor AFX by protein kinase B. Nature 398: 630-634.
19. Li, J., C. Yen, D. Liaw, K. Podsypanina, S. Bose, S.I. Wang, J. Puc, C. Miliaresis, L. Rodgers, R. McCombie et al. 1997. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 275: 1943-1947.
20. Li, J., L. Simpson, M. Takahashi, C. Miliaresis, M.P. Myers, N. Tonks, and R. Parson. 1998. The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the AKT/protein kinase B oncogene. Cancer Res. 58: 5667-5672.
21. Liaw, D., D.J. Marsh, J. Li, P.L. Dahia, S.I. Wang, Z. Zheng, S. Bose, K.M. Call, H.C. Tsou, M. Peacocke et al. 1997. Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. Nat. Genet. 16: 64-67.
22. Maehama, T. and J.E. Dixon. 1998. The tumor suppressor, PTEN/ MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J. Biol. Chem. 273: 13375-13378.
23. Mandruzzato, S., F. Brasseur, G. Andry, T. Boon, and P. van der Bruggen. 1997. A CASP-8 mutation recognized by cytolytic T lymphocytes on a human head and neck carcinoma. J. Exp. Med. 186: 785-793.
24. Marsh, D.J., P.L. Dahia, Z. Zheng, D. Liaw, R. Parsons, R.J. Gorlin, and C. Eng. 1997. Germline mutations in PTEN are present in Bannayan-Zonana syndrome. Nat. Genet. 16: 333-334.
25. Maxwell, P.H., M.S. Wiesener, G.W. Chang, S.C. Clifford, E.C. Vaux, M.E. Cockman, C.C. Wykoff, C.W. Pugh, E.R. Maher, and P.J. Ratcliffe. 1999. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399: 271-275.
26. Mazure, N.M., E.Y. Chen, K.R. Laderoute, and A.J. Giaccia. 1997. Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformed cells through a hypoxia inducible factor-1 transcriptional element. Blood 90: 3322-3331.
27. Pap, M. and G.M. Cooper. 1998. Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway. J. Biol. Chem. 273: 19929-19932.
28. Petersdorf, S.H. and R.B. Livingston. 1994. High dose chemotherapy for the treatment of malignant brain tumors. J. Neurooncol. 20: 155-163.
29. Ryan, H.E., J. Lo, and R.S. Johnson. 1998. HIF-1 alpha is required for solid tumor formation and embryonic vascularization. EMBO J. 17: 3005-3015.
30. Semenza, G.L. 1998. Hypoxia-inducible factor 1: Master regulator of O2 homeostasis. Curr. Opin. Genet. Dev. 8: 588-594.
31. Semenza, G.L., M.K. Nejfelt, S.M. Chi, and S.E. Antonarakis. 1991. Hypoxia-inducible nuclear factors bind to an enhancer element located 3′ to the human erythropoietin gene. Proc. Natl. Acad. Sci. 88: 5680-5684.
32. Stambolic, V., A. Suzuki, J.L. de la Pompa, G.M. Brothers, C. Mirtsos, T. Sasaki, J. Ruland, J.M. Penninger, D.P. Siderovski, and T.W. Mak. 1998. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell 95: 29-39.
33. Steck, P.A., M.A. Pershouse, S.A. Jasser, W.K. Yung, H. Lin, A.H. Ligon, L.A. Langford, M.L. Baumgard, T. Hattier, T. Davis et al. 1997. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat. Genet. 15: 356-362.
34. Wang, D., H.J. Huang, A. Kazlauskas, and W.K. Cavenee. 1999. Induction of vascular endothelial growth factor expression in endothelial cells by platelet-derived growth factor through the activation of phosphatidylinositol 3-kinase. Cancer Res. 59: 1464-1472.
35. Warren, R.S., H. Yuan, M.R. Matli, N. Ferrara, and D.B. Donner. 1996. Induction of vascular endothelial growth factor by insulin-like growth factor 1 in colorectal carcinoma. J. Biol. Chem. 271: 29483-29488.
36. Wesseling, P., D.J. Ruiter, and P.C. Burger. 1997. Angiogenesis in brain tumors; pathobiological and clinical aspects. J. Neurooncol. 32: 253-265.
37. Yuan, J. and P.M. Glazer. 1998. Mutagenesis induced by the tumor microenvironment. Mutat. Res. 400: 439-446.
38. Zelzer, E., Y. Levy, C. Kahana, B.Z. Shilo, M. Rubinstein, and B. Cohen. 1998. Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha/ARNT. EMBO J. 17: 5085-5094.