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Volumn 4, Issue 1, 2010, Pages 146-152

MET molecular mechanisms and therapies in lung cancer

Author keywords

Hepatocyte growth factor; Lung cancer; MET; Paxillin; Tyrosine kinase

Indexed keywords

CYTOSKELETON PROTEIN; GELDANAMYCIN; MET ENZYME; PAXILLIN; PROTEIN TYROSINE KINASE; SCATTER FACTOR; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

EID: 77449141050     PISSN: 19336918     EISSN: 19336926     Source Type: Journal    
DOI: 10.4161/cam.4.1.10973     Document Type: Review
Times cited : (52)

References (54)
  • 2
    • 0021241398 scopus 로고
    • Molecular cloning of a new transforming gene from a chemically transformed human cell line
    • Cooper CS, Park M, Blair DG, Tainsky MA, Huebner K, Croce CM, et al. Molecular cloning of a new transforming gene from a chemically transformed human cell line. Nature 1984; 311:29-33.
    • (1984) Nature , vol.311 , pp. 29-33
    • Cooper, C.S.1    Park, M.2    Blair, D.G.3    Tainsky, M.A.4    Huebner, K.5    Croce, C.M.6
  • 3
  • 4
    • 0027437547 scopus 로고
    • Scatter factor/hepatocyte growth factor and its receptor, the c-met tyrosine kinase, can mediate a signal exchange between mesenchyme and epithelia during mouse development
    • Sonnenberg E, Meyer D, Weidner KM, Birchmeier C. Scatter factor/hepatocyte growth factor and its receptor, the c-met tyrosine kinase, can mediate a signal exchange between mesenchyme and epithelia during mouse development. J Cell Biol 1993; 123:223-35.
    • (1993) J Cell Biol , vol.123 , pp. 223-235
    • Sonnenberg, E.1    Meyer, D.2    Weidner, K.M.3    Birchmeier, C.4
  • 6
    • 67649393456 scopus 로고    scopus 로고
    • MET pathway as a therapeutic target
    • Kim ES, Salgia R. MET pathway as a therapeutic target. J Thoracic Oncol 2009; 4:444-7.
    • (2009) J Thoracic Oncol , vol.4 , pp. 444-447
    • Kim, E.S.1    Salgia, R.2
  • 7
    • 0023661693 scopus 로고
    • Scatter factor is a fibroblast-derived modulator of epithelial cell mobility
    • Stoker M, Gherardi E, Perryman M, Gray J. Scatter factor is a fibroblast-derived modulator of epithelial cell mobility. Nature (London) 1987; 327:239-42.
    • (1987) Nature (London) , vol.327 , pp. 239-242
    • Stoker, M.1    Gherardi, E.2    Perryman, M.3    Gray, J.4
  • 10
    • 0028276786 scopus 로고
    • Invasiveness and metastasis of NIH 3T3 cells induced by Met-hepatocyte growth factor/scatter factor autocrine stimulation
    • Rong S, Segal S, Anver M, Resau JH, VandeWoude GF. Invasiveness and metastasis of NIH 3T3 cells induced by Met-hepatocyte growth factor/scatter factor autocrine stimulation. Proc Nati Acad Sci 1994; 91:4731-5.
    • (1994) Proc Nati Acad Sci , vol.91 , pp. 4731-4735
    • Rong, S.1    Segal, S.2    Anver, M.3    Resau, J.H.4    VandeWoude, G.F.5
  • 12
    • 2942642503 scopus 로고    scopus 로고
    • Therapeutic targeting of the receptor tyrosine kinase met
    • Sattler M, Ma PC, Salgia R. Therapeutic targeting of the receptor tyrosine kinase met. Cancer Treat Res 2004; 119:121-38.
    • (2004) Cancer Treat Res , vol.119 , pp. 121-138
    • Sattler, M.1    Ma, P.C.2    Salgia, R.3
  • 13
    • 0037686249 scopus 로고    scopus 로고
    • Activated c-Met signals through PI3K with dramatic effects on cytoskeletal functions in small cell lung cancer
    • Maulik G, Madhiwala P, Brooks S, Ma PC, Kijima T, Tibaldi EV, et al. Activated c-Met signals through PI3K with dramatic effects on cytoskeletal functions in small cell lung cancer. J Cell Mol Med 2002; 6:539-53.
    • (2002) J Cell Mol Med , vol.6 , pp. 539-553
    • Maulik, G.1    Madhiwala, P.2    Brooks, S.3    Ma, P.C.4    Kijima, T.5    Tibaldi, E.V.6
  • 14
    • 0141988690 scopus 로고    scopus 로고
    • c-MET mutational analysis in small cell lung cancer: Novel juxtamembrane domain mutations regulating cytoskeletal functions
    • Ma PC, Kijima T, Maulik G, Fox EA, Sattler M, Griffin JD, et al. c-MET mutational analysis in small cell lung cancer: novel juxtamembrane domain mutations regulating cytoskeletal functions. Cancer Research 2003; 63:6272-81.
    • (2003) Cancer Research , vol.63 , pp. 6272-6281
    • Ma, P.C.1    Kijima, T.2    Maulik, G.3    Fox, E.A.4    Sattler, M.5    Griffin, J.D.6
  • 15
    • 0028351702 scopus 로고
    • A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family
    • Ponzetto C, Bardelli A, Zhen Z, Maina F, della Zonca P, Giordano S, et al. A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family. Cell 1994; 77:261-71.
    • (1994) Cell , vol.77 , pp. 261-271
    • Ponzetto, C.1    Bardelli, A.2    Zhen, Z.3    Maina, F.4    della Zonca, P.5    Giordano, S.6
  • 16
    • 0031045203 scopus 로고    scopus 로고
    • Regulation of the urokinase-type plasminogen activator gene by the oncogene Tpr-Met involves GRB2
    • Besser D, Bardelli A, Didichenko S, Thelen M, Comoglio PM, Ponzetto C, et al. Regulation of the urokinase-type plasminogen activator gene by the oncogene Tpr-Met involves GRB2. Oncogene 1997; 14:705-11.
    • (1997) Oncogene , vol.14 , pp. 705-711
    • Besser, D.1    Bardelli, A.2    Didichenko, S.3    Thelen, M.4    Comoglio, P.M.5    Ponzetto, C.6
  • 17
    • 0028337426 scopus 로고
    • Hepatocyte growth factor stimulates expression of plasminogen activator inhibitor type 1 and tissue factor in HepG2 cells
    • Wojta J, Nakamura T, Fabry A, Hufnagl P, Beckmann R, McGrath K, et al. Hepatocyte growth factor stimulates expression of plasminogen activator inhibitor type 1 and tissue factor in HepG2 cells. Blood 1994; 84:151-7.
    • (1994) Blood , vol.84 , pp. 151-157
    • Wojta, J.1    Nakamura, T.2    Fabry, A.3    Hufnagl, P.4    Beckmann, R.5    McGrath, K.6
  • 18
    • 0029764106 scopus 로고    scopus 로고
    • Mechanisms of hepatocyte growth factor stimulation of keratinocyte metalloproteinase production
    • Dunsmore SE, Rubin JS, Kovacs SO, Chedid M, Parks WC, Welgus HG. Mechanisms of hepatocyte growth factor stimulation of keratinocyte metalloproteinase production. J Biol Chem 1996; 271:24576-82.
    • (1996) J Biol Chem , vol.271 , pp. 24576-24582
    • Dunsmore, S.E.1    Rubin, J.S.2    Kovacs, S.O.3    Chedid, M.4    Parks, W.C.5    Welgus, H.G.6
  • 19
    • 0026722243 scopus 로고
    • Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth
    • Bussolino F, Di Renzo MF, Ziche M, Bocchietto E, Olivero M, Naldini L, et al. Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth. J Cell Biol 1992; 119:629-41.
    • (1992) J Cell Biol , vol.119 , pp. 629-641
    • Bussolino, F.1    Di Renzo, M.F.2    Ziche, M.3    Bocchietto, E.4    Olivero, M.5    Naldini, L.6
  • 20
    • 8044219670 scopus 로고    scopus 로고
    • Overexpression and activation of hepatocyte growth factor/scatter factor in human non-small-cell lung carcinomas
    • Olivero M, Rizzo M, Madeddu R, Casadio C, Pennacchietti S, Nicotra MR, et al. Overexpression and activation of hepatocyte growth factor/scatter factor in human non-small-cell lung carcinomas. Br J Cancer 1996; 74:1862-8.
    • (1996) Br J Cancer , vol.74 , pp. 1862-1868
    • Olivero, M.1    Rizzo, M.2    Madeddu, R.3    Casadio, C.4    Pennacchietti, S.5    Nicotra, M.R.6
  • 21
    • 13944276728 scopus 로고    scopus 로고
    • Functional expression and mutations of c-Met and its therapeutic inhibition with SU11274 and small interfering RNA in Non-small cell lung cancer
    • Ma PC, Jagadeeswaran R, Jagadeesh S, Tretiakova MS, Nallasura V, Fox EA, et al. Functional expression and mutations of c-Met and its therapeutic inhibition with SU11274 and small interfering RNA in Non-small cell lung cancer. Cancer Research 2005; 65:1479-88.
    • (2005) Cancer Research , vol.65 , pp. 1479-1488
    • Ma, P.C.1    Jagadeeswaran, R.2    Jagadeesh, S.3    Tretiakova, M.S.4    Nallasura, V.5    Fox, E.A.6
  • 22
    • 85193273898 scopus 로고    scopus 로고
    • Kanteti R, Yala S, Furguson MK, Salgia R. MET HGF, EGFR and PXN gene copy number in lung cancer using DNA extracts from FFPE archival samples, and prognostic significance. J Environ Pathol Toxicol Oncol 2009; 28:89-98.
    • Kanteti R, Yala S, Furguson MK, Salgia R. MET HGF, EGFR and PXN gene copy number in lung cancer using DNA extracts from FFPE archival samples, and prognostic significance. J Environ Pathol Toxicol Oncol 2009; 28:89-98.
  • 24
    • 0033531243 scopus 로고    scopus 로고
    • Expression of the focal adhesion protein paxillin in lung cancer and its relation to cell motility
    • Salgia R, Li JL, Ewaniuk D, Wang YB, Sattler M, Chen WC, et al. Expression of the focal adhesion protein paxillin in lung cancer and its relation to cell motility. Oncogene 1999; 18:67-77.
    • (1999) Oncogene , vol.18 , pp. 67-77
    • Salgia, R.1    Li, J.L.2    Ewaniuk, D.3    Wang, Y.B.4    Sattler, M.5    Chen, W.C.6
  • 25
    • 0141481285 scopus 로고    scopus 로고
    • A novel small molecule Met inhibitor induces apoptosis in cells transformed by the oncogenic TPR-MET tyrosine kinase
    • Sattler M, Pride YB, Ma PC, Gramlich JL, Chu SC, Quinnan LA, et al. A novel small molecule Met inhibitor induces apoptosis in cells transformed by the oncogenic TPR-MET tyrosine kinase. Cancer Research 2003; 63:5462-9.
    • (2003) Cancer Research , vol.63 , pp. 5462-5469
    • Sattler, M.1    Pride, Y.B.2    Ma, P.C.3    Gramlich, J.L.4    Chu, S.C.5    Quinnan, L.A.6
  • 28
    • 67649225195 scopus 로고    scopus 로고
    • No somatic genetic change in the paxillin gene in nonsmall-cell lung cancer
    • Pallier K, Houllier AM, Cazes A, Laurent-Puig P, Blons H. No somatic genetic change in the paxillin gene in nonsmall-cell lung cancer. Mol Carcinog 2009; 48:581-5.
    • (2009) Mol Carcinog , vol.48 , pp. 581-585
    • Pallier, K.1    Houllier, A.M.2    Cazes, A.3    Laurent-Puig, P.4    Blons, H.5
  • 29
    • 57749089758 scopus 로고    scopus 로고
    • Downregulation of Micro-Rna-1 (miR-1) in lung cancer: Suppression of tumorigenic property of lung cancer cells and their sensitization to doxorubicin-induced apoptosis by miR-1
    • Nasser MW, Datta J, Nuovo G, Kutay H, Motiwala T, Majumder S, et al. Downregulation of Micro-Rna-1 (miR-1) in lung cancer: suppression of tumorigenic property of lung cancer cells and their sensitization to doxorubicin-induced apoptosis by miR-1. J Biol Chem 2008; 283:33394-405.
    • (2008) J Biol Chem , vol.283 , pp. 33394-33405
    • Nasser, M.W.1    Datta, J.2    Nuovo, G.3    Kutay, H.4    Motiwala, T.5    Majumder, S.6
  • 31
    • 33750711384 scopus 로고    scopus 로고
    • A phase I trial of twice-weekly 17-allylamino-demethoxy-geldanamycin in patients with advanced cancer
    • Nowakowski GS, McCollum AK, Ames MM, Mandrekar SJ, Reid JM, Adjei AA, et al. A phase I trial of twice-weekly 17-allylamino-demethoxy-geldanamycin in patients with advanced cancer. Clin Cancer Res 2006; 12:6087-93.
    • (2006) Clin Cancer Res , vol.12 , pp. 6087-6093
    • Nowakowski, G.S.1    McCollum, A.K.2    Ames, M.M.3    Mandrekar, S.J.4    Reid, J.M.5    Adjei, A.A.6
  • 32
    • 0034532066 scopus 로고    scopus 로고
    • Modulation of metastasis phenotypes of non-small cell lung cancer cells by 17-allylamino 17-demethoxy geldanamycin
    • Nguyen DM, Desai S, Chen A, Weiser TS, Schrump DS. Modulation of metastasis phenotypes of non-small cell lung cancer cells by 17-allylamino 17-demethoxy geldanamycin. Ann Thorac Surg 2000; 70:1853-60.
    • (2000) Ann Thorac Surg , vol.70 , pp. 1853-1860
    • Nguyen, D.M.1    Desai, S.2    Chen, A.3    Weiser, T.S.4    Schrump, D.S.5
  • 33
    • 20044384168 scopus 로고    scopus 로고
    • Phase I trial of 17-allylamino-17-demethoxygeldanamycin in patients with advanced cancer
    • Goetz MP, Toft D, Reid J, Ames M, Stensgard B, Safgren S, et al. Phase I trial of 17-allylamino-17-demethoxygeldanamycin in patients with advanced cancer. J Clin Oncol 2005; 23:1078-87.
    • (2005) J Clin Oncol , vol.23 , pp. 1078-1087
    • Goetz, M.P.1    Toft, D.2    Reid, J.3    Ames, M.4    Stensgard, B.5    Safgren, S.6
  • 34
    • 85047689927 scopus 로고    scopus 로고
    • An uncleavable form of proscatter factor suppresses tumor growth and dissemination in mice
    • Mazzone M, Basilico C, Cavassa S, Pennacchietti S, Risio M, Naldini L, et al. An uncleavable form of proscatter factor suppresses tumor growth and dissemination in mice. J Clin Invest 2004; 114:1418-32.
    • (2004) J Clin Invest , vol.114 , pp. 1418-1432
    • Mazzone, M.1    Basilico, C.2    Cavassa, S.3    Pennacchietti, S.4    Risio, M.5    Naldini, L.6
  • 35
    • 0033999314 scopus 로고    scopus 로고
    • Disassociation of met-mediated biological responses in vivo: The natural hepatocyte growth factor/scatter factor splice variant NK2 antagonizes growth but facilitates metastasis
    • Otsuka T, Jakabczak J, Vieira W, Bottaro DP, Breckenridge D, Larochelle WJ, et al. Disassociation of met-mediated biological responses in vivo: the natural hepatocyte growth factor/scatter factor splice variant NK2 antagonizes growth but facilitates metastasis. Mol Cell Biol 2000; 20:2055-65.
    • (2000) Mol Cell Biol , vol.20 , pp. 2055-2065
    • Otsuka, T.1    Jakabczak, J.2    Vieira, W.3    Bottaro, D.P.4    Breckenridge, D.5    Larochelle, W.J.6
  • 36
    • 69249088890 scopus 로고    scopus 로고
    • Angioinhibitory action of NK4 involves impaired extra-cellular assembly of fibronectin mediated by perlecan-NK4 association
    • Sakai K, Nakamura T, Matsumoto K, Nakamura T. Angioinhibitory action of NK4 involves impaired extra-cellular assembly of fibronectin mediated by perlecan-NK4 association. J Biol Chem 2009; 284:22491-9.
    • (2009) J Biol Chem , vol.284 , pp. 22491-22499
    • Sakai, K.1    Nakamura, T.2    Matsumoto, K.3    Nakamura, T.4
  • 37
    • 33947605712 scopus 로고    scopus 로고
    • NK4, an antagonist of hepatocyte growth factor (HGF), inhibits growth of multiple myeloma cells: Molecular targeting of angiogenic growth factor
    • Du W, Hattori Y, Yamada T, Matsumoto K, Nakamura T, Sagawa M, et al. NK4, an antagonist of hepatocyte growth factor (HGF), inhibits growth of multiple myeloma cells: molecular targeting of angiogenic growth factor. Blood 2007; 109:3042-9.
    • (2007) Blood , vol.109 , pp. 3042-3049
    • Du, W.1    Hattori, Y.2    Yamada, T.3    Matsumoto, K.4    Nakamura, T.5    Sagawa, M.6
  • 40
    • 34548561684 scopus 로고    scopus 로고
    • Pharmacokinetics and safety of a fully human hepatocyte growth factor antibody, AMG 102, in cynomolgus monkeys
    • Kakkar T, Ma M, Zhuang Y, Patton A, Hu Z, Mounho B. Pharmacokinetics and safety of a fully human hepatocyte growth factor antibody, AMG 102, in cynomolgus monkeys. Pharm Res 2007; 24:1910-8.
    • (2007) Pharm Res , vol.24 , pp. 1910-1918
    • Kakkar, T.1    Ma, M.2    Zhuang, Y.3    Patton, A.4    Hu, Z.5    Mounho, B.6
  • 41
    • 36749042647 scopus 로고    scopus 로고
    • AMG 102, a fully human anti-hepatocyte growth factor/scatter factor neutralizing antibody, enhances the efficacy of temozolomide or docetaxel in U-87 MG cells and xenografts
    • Jun HT, Sun J, Rex K, Radinsky R, Kendall R, Coxon A, et al. AMG 102, a fully human anti-hepatocyte growth factor/scatter factor neutralizing antibody, enhances the efficacy of temozolomide or docetaxel in U-87 MG cells and xenografts. Clin Cancer Res 2007; 13:6735-42.
    • (2007) Clin Cancer Res , vol.13 , pp. 6735-6742
    • Jun, H.T.1    Sun, J.2    Rex, K.3    Radinsky, R.4    Kendall, R.5    Coxon, A.6
  • 42
    • 33749575548 scopus 로고    scopus 로고
    • Inhibition of c-Met and prevention of spontaneous metastatic spreading by the 2-indolinone RPI-1
    • Cassinelli G, Lanzi C, Petrangolini G, Tortoreto M, Pratesi G, Cuccuru G, et al. Inhibition of c-Met and prevention of spontaneous metastatic spreading by the 2-indolinone RPI-1. Mol Cancer Ther 2006; 5:2388-97.
    • (2006) Mol Cancer Ther , vol.5 , pp. 2388-2397
    • Cassinelli, G.1    Lanzi, C.2    Petrangolini, G.3    Tortoreto, M.4    Pratesi, G.5    Cuccuru, G.6
  • 43
    • 0037173756 scopus 로고    scopus 로고
    • K252a inhibits the oncogenic properties of Met, the HGF receptor
    • Morotti A, Mila S, Accornero P, Tagliabue E, Ponzetto C. K252a inhibits the oncogenic properties of Met, the HGF receptor. Oncogene 2002; 21:4885-93.
    • (2002) Oncogene , vol.21 , pp. 4885-4893
    • Morotti, A.1    Mila, S.2    Accornero, P.3    Tagliabue, E.4    Ponzetto, C.5
  • 44
    • 16844374901 scopus 로고    scopus 로고
    • A selective small molecule c-MET inhibitor, PHA665752, cooperates with rapamycin
    • Ma PC, Schaefer E, Christensen JG, Salgia R. A selective small molecule c-MET inhibitor, PHA665752, cooperates with rapamycin. Clinical Cancer Research 2005; 11:2312-9.
    • (2005) Clinical Cancer Research , vol.11 , pp. 2312-2319
    • Ma, P.C.1    Schaefer, E.2    Christensen, J.G.3    Salgia, R.4
  • 45
    • 34248575532 scopus 로고    scopus 로고
    • A selective small molecule inhibitor of c-Met, PHA665752, inhibits tumorigenicity and angiogenesis in mouse lung cancer xenografts
    • Puri N, Khramtsov A, Salman A, Nallasura V, Hetzel JT, Jagadeeswaran R, et al. A selective small molecule inhibitor of c-Met, PHA665752, inhibits tumorigenicity and angiogenesis in mouse lung cancer xenografts. Cancer Research 2007; 67:3529-34.
    • (2007) Cancer Research , vol.67 , pp. 3529-3534
    • Puri, N.1    Khramtsov, A.2    Salman, A.3    Nallasura, V.4    Hetzel, J.T.5    Jagadeeswaran, R.6
  • 46
    • 34249324494 scopus 로고    scopus 로고
    • An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms
    • Zou HY, Li Q, Lee JH, Arango ME, McDonnell SR, Yamazaki S, et al. An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms. Cancer Research 2007; 67:4408-17.
    • (2007) Cancer Research , vol.67 , pp. 4408-4417
    • Zou, H.Y.1    Li, Q.2    Lee, J.H.3    Arango, M.E.4    McDonnell, S.R.5    Yamazaki, S.6
  • 47
    • 44849126091 scopus 로고    scopus 로고
    • Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors
    • McDermott U, Iafrate AJ, Gray NS, Shioda T, Classon M, Maheswaran S, et al. Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors. Cancer Research 2008; 68:3389-95.
    • (2008) Cancer Research , vol.68 , pp. 3389-3395
    • McDermott, U.1    Iafrate, A.J.2    Gray, N.S.3    Shioda, T.4    Classon, M.5    Maheswaran, S.6
  • 48
    • 70350230210 scopus 로고    scopus 로고
    • Inhibition of tumor cell growth, invasion, and metastasis by EXEL-2880 (XL880, GSK1363089), a novel inhibitor of HGF and VEGF receptor tyrosine kinases
    • Qian F, Engst S, Yamaguchi K, Yu P, Won KA, Mock L, et al. Inhibition of tumor cell growth, invasion, and metastasis by EXEL-2880 (XL880, GSK1363089), a novel inhibitor of HGF and VEGF receptor tyrosine kinases. Cancer Res 2009; 69:8009.
    • (2009) Cancer Res , vol.69 , pp. 8009
    • Qian, F.1    Engst, S.2    Yamaguchi, K.3    Yu, P.4    Won, K.A.5    Mock, L.6
  • 50
    • 73149091443 scopus 로고    scopus 로고
    • SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo
    • Buchanan SG, Hendle J, Lee PS, Smith CR, Bounaud PY, Jessen KA, et al. SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo. Mol Cancer Ther 2009; 8:1-10.
    • (2009) Mol Cancer Ther , vol.8 , pp. 1-10
    • Buchanan, S.G.1    Hendle, J.2    Lee, P.S.3    Smith, C.R.4    Bounaud, P.Y.5    Jessen, K.A.6
  • 51
    • 34249075147 scopus 로고    scopus 로고
    • MET amplification leads to Gefitinib resistance in lung cancer by activating ERBB3 Signaling
    • Engelman JA, Zejnullahu K, Mitsudomi T, Song Y, Hyland C, Park JO, et al. MET amplification leads to Gefitinib resistance in lung cancer by activating ERBB3 Signaling. Science 2007; 316:1039-43.
    • (2007) Science , vol.316 , pp. 1039-1043
    • Engelman, J.A.1    Zejnullahu, K.2    Mitsudomi, T.3    Song, Y.4    Hyland, C.5    Park, J.O.6
  • 52
    • 38049150665 scopus 로고    scopus 로고
    • MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib
    • Bean J, Brennan C, Shih JY, Riely G, Viale A, Wang L, et al. MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib. Proc Natl Acad Sci USA 2007; 104:20932-7.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 20932-20937
    • Bean, J.1    Brennan, C.2    Shih, J.Y.3    Riely, G.4    Viale, A.5    Wang, L.6
  • 53
    • 79151480325 scopus 로고    scopus 로고
    • Tolfenamic acid decreases c-Met expression through Sp proteins degradation and inhibits lung cancer cells growth and tumor formation in orthotopic mice
    • In press
    • Colon J, Basha MR, Madero-Visbal R, Konduri S, Baker CH, Herrera LJ, et al. Tolfenamic acid decreases c-Met expression through Sp proteins degradation and inhibits lung cancer cells growth and tumor formation in orthotopic mice. Invest New Drugs 2009; In press.
    • (2009) Invest New Drugs
    • Colon, J.1    Basha, M.R.2    Madero-Visbal, R.3    Konduri, S.4    Baker, C.H.5    Herrera, L.J.6
  • 54
    • 85193276452 scopus 로고    scopus 로고
    • Siddiqui S, Loganathan S, Krishnaswamy S, Faoro L, Jagadeeswaran R, Salgia R. C. elegans as a model organism for in vivo screening in cancer: effects of human c-Met in lung cancer affect C. elegans vulva phenotypes. Cancer Biol Ther 2008; 7:856-63.
    • Siddiqui S, Loganathan S, Krishnaswamy S, Faoro L, Jagadeeswaran R, Salgia R. C. elegans as a model organism for in vivo screening in cancer: effects of human c-Met in lung cancer affect C. elegans vulva phenotypes. Cancer Biol Ther 2008; 7:856-63.


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